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medium_hidden_intermediate_07149 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in osteoblast differentiation. Evidence for this gene reports a log2 fold change of 1.162 and an adjusted p-value of 0.001285. Which disease is connected to this gene through genomic alterations? | malignant colon neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07149","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in osteoblast differentiation... | |
medium_hidden_intermediate_07150 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the processing of capped intron-containing pre-mRNA. One of these genes shows a log2 fold change of 1.542 and an adjusted p-value of 0.04172 in a specific study. Which disease is associated with this gene? | microcephaly 24, primary, autosomal recessive | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07150","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the processing of capp... | |
medium_hidden_intermediate_07151 | Two genes are structurally linked from Human immunodeficiency virus 1 to esophageal squamous cell carcinoma via an upregulation relationship followed by an association relationship. One of these genes is reported in a study (GSE108897) on macrophages with a log2 fold change of 2.375 and an adjusted p-value of 0.01298. ... | Retinol-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07151","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Human immunodeficiency virus 1 to esophageal squamous cell carcinoma via an upregulat... | |
medium_hidden_intermediate_07152 | Measles morbillivirus upregulates a gene that participates in the amplification of signal from the kinetochores. Evidence for one such gene reports a log2 fold change of 1.653 and an adjusted p-value of 0.001776. Which protein is encoded by that gene? | Spindle and kinetochore-associated protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07152","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in the amplification of signal from the kinetochores. Evidence fo... | |
medium_hidden_intermediate_07154 | Zaire ebolavirus upregulates a gene that participates in the metabolism of amino acids and derivatives. Evidence for this specific gene reports a log2 fold change of 1.382 and an adjusted p-value of 0.0003585. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07154","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that participates in the metabolism of amino acids and derivatives. Evidence for this sp... | |
medium_hidden_intermediate_07156 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and enables tRNA (cytidine-3-)-methyltransferase activity. This specific gene exhibits a log2 fold change of -1.109 and an adjusted p-value of 0.01404. Which protein is encoded by this gene? | tRNA N(3)-cytidine methyltransferase METTL2B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07156","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and enables tRNA (cytid... | |
medium_hidden_intermediate_07157 | Pegivirus C is reported to downregulate a gene that is involved in chromatin organization. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.081 and an adjusted p-value of 0.005686. Which protein is encoded by this specific gene? | THAP domain-containing protein 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07157","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in chromatin organization. In a study of peripheral blood mo... | |
medium_hidden_intermediate_07158 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is downregulated by Vaccinia virus and binds to SCO2. This gene exhibits a log2 fold change of -1.494 and an adjusted p-value of 0.03067. Which protein is encoded by this gene? | Coenzyme Q-binding protein COQ10 homolog B, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07158","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is downregulated by Vaccinia virus and binds to SCO2. Th... | |
medium_hidden_intermediate_07160 | Vaccinia virus downregulates a gene product that is located in the late endosome membrane. Transcriptomic data from a cervical adenocarcinoma cell line (study GSE11238) indicates that one such entity has a log2 fold change of -1.032 and an adjusted p-value of 0.01191. Which protein is encoded by this specific gene? | UBX domain-containing protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07160","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene product that is located in the late endosome membrane. Transcriptomic data from a cervic... | |
medium_hidden_intermediate_07161 | A gene is upregulated by Hepacivirus C and participates in Glycosphingolipid metabolism. Evidence for this gene reports a log2 fold change of 1.116 and an adjusted p-value of 0.01129. Which cell type is this gene enriched in? | naive B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07161","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Hepacivirus C and participates in Glycosphingolipid metabolism. Evidence for this gene reports a lo... | |
medium_hidden_intermediate_07162 | Two genes are upregulated by Vaccinia virus and interact with HIST1H2BG. One of these genes shows a log2 fold change of 1.240 and an adjusted p-value of 4.044e-07 in cervical adenocarcinoma cells. Which cell type is enriched for this specific gene? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07162","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and interact with HIST1H2BG. One of these genes shows a log2 fold change of 1.24... | |
medium_hidden_intermediate_07164 | Zika virus downregulates a specific gene, which in turn interacts with RPA2. Experimental data from glioma stem cells (study GSE114907) indicates that this intermediate gene has a log2 fold change of -1.645 and an adjusted p-value of 0.005475. Which gene binds to this intermediate entity? | LDHB | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07164","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with RPA2. Experimental data from glioma stem cells (study... | |
medium_hidden_intermediate_07165 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of SNARE complex assembly. Evidence for this gene reports a log2 fold change of 1.010 and an adjusted p-value of 0.03531. Which disease is associated with this gene as a biomarker? | arthrogryposis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07165","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of SNARE co... | |
medium_hidden_intermediate_07166 | A genetic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is associated with a gene product that is located in the endoplasmic reticulum membrane. Evidence indicates that for this specific entity, in the absence of ceramide, the N terminus of its first transmembrane helix is inserted into the endoplasmic reticul... | Transmembrane 4 L6 family member 20 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07166","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A genetic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is associated with a gene product that is located in the en... | |
medium_hidden_intermediate_07167 | Hepacivirus C is associated with the downregulation of a gene whose protein product is located in the endoplasmic reticulum membrane. Evidence for this specific gene reports a log2 fold change of -1.406 and an adjusted p-value of 0.03116. Which protein is encoded by this gene? | G-protein-signaling modulator 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07167","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the downregulation of a gene whose protein product is located in the endoplasmic reticulum ... | |
medium_hidden_intermediate_07170 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and participates in Signal Transduction. This specific gene exhibits a log2 fold change of 3.359 and an adjusted p-value of 0.04936. Which protein is encoded by this gene? | Atypical chemokine receptor 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07170","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and participate... | |
medium_hidden_intermediate_07172 | Rhinovirus A upregulates a gene that is located in the mitochondrion. Evidence for one such gene reports a log2 fold change of 1.042 and an adjusted p-value of 0.001276. Which disease is associated with this gene as a biomarker? | squamous cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07172","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A upregulates a gene that is located in the mitochondrion. Evidence for one such gene reports a log2 fold change ... | |
medium_hidden_intermediate_07173 | ZRANB1 interacts with a specific protein that enables protein binding. Evidence regarding this protein states: 'Consistent with its cytoplasmic localization, we detected an interaction between this protein and vinexin, a protein involved in linking signaling to the cytoskeleton.' Which cell type is this protein enriche... | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07173","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"ZRANB1 interacts with a specific protein that enables protein binding. Evidence regarding this protein states: 'Consistent w... | |
medium_hidden_intermediate_07174 | A gene upregulated by Vaccinia virus is enriched in naive CD4+ T cells. Evidence for one such gene reports a log2 fold change of 5.323 and an adjusted p-value of 1.177e-08. Which cellular component is this gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07174","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene upregulated by Vaccinia virus is enriched in naive CD4+ T cells. Evidence for one such gene reports a log2 fold chang... | |
medium_hidden_intermediate_07176 | A gene is downregulated by Primate bocaparvovirus 1 and is enriched in Naive B cells. Experimental evidence for this gene reports a log2 fold change of -1.814 and an adjusted p-value of 0.01605. Which protein is encoded by this gene? | Protein RIC-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07176","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is enriched in Naive B cells. Experimental evidence for this gene re... | |
medium_hidden_intermediate_07177 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its product binds to HCFC1. This gene exhibits a log2 fold change of approximately 1.39 and an adjusted p-value of 0.0022. Which protein is encoded by this gene? | Forkhead box protein K2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07177","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its product binds to HCFC1. T... | |
medium_hidden_intermediate_07178 | In a study of West Nile virus infection in monocyte-derived dendritic cells (GSE136342), a specific gene is downregulated by the virus and its product enables protein binding. This gene exhibits a log2 fold change of approximately -1.022 and an adjusted p-value of 0.0007374. Which protein is encoded by this gene? | MANSC domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07178","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of West Nile virus infection in monocyte-derived dendritic cells (GSE136342), a specific gene is downregulated by... | |
medium_hidden_intermediate_07180 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in amino acid transport across the plasma membrane. One such gene exhibits a log2 fold change of 1.771 and an adjusted p-value of 0.001245. Which protein is encoded by this specific gene? | Large neutral amino acids transporter small subunit 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07180","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in amino acid tra... | |
medium_hidden_intermediate_07181 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in protein N-linked glycosylation. Evidence for this gene reports a log2 fold change of 4.251 and an adjusted p-value of 0.002881. Which disease is associated with this gene through genomic alterations? | pernicious anemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07181","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in protein N-linked glycosyla... | |
medium_hidden_intermediate_07182 | SIN3A interacts with a specific protein that is involved in transcription by RNA polymerase II. Evidence indicates that this protein interacts with the corepressor complex mSin3A/histone deacetylase (HDAC) at the hTERT promoter. Which cell type is this protein enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07182","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"SIN3A interacts with a specific protein that is involved in transcription by RNA polymerase II. Evidence indicates that this... | |
medium_hidden_intermediate_07184 | Two genes are downregulated by Human betaherpesvirus 5 and are associated with proliferative diabetic retinopathy. One of these genes exhibits a log2 fold change of -1.974 and an adjusted p-value of 0.0003601 in foreskin fibroblast cell lines. Which disease is causally linked to this specific gene? | macular degeneration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07184","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human betaherpesvirus 5 and are associated with proliferative diabetic retinopathy. One of th... | |
medium_hidden_intermediate_07185 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the intrinsic apoptotic signaling pathway in response to DNA damage. Experimental evidence for this gene reports a log2 fold change of approximately 1.625 and an adjusted p-value of approximately 0.02065. Which protein is ... | Modulator of apoptosis 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07185","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the intrinsic apoptotic si... | |
medium_hidden_intermediate_07187 | Rhinovirus A infection is associated with the downregulation of genes that enable dipeptidyl-peptidase activity. In a study of cytotoxic T-lymphocytes (GSE106475), one such gene exhibited a log2 fold change of -2.271 and an adjusted p-value of 0.008174. Which protein is encoded by this specific gene? | Dipeptidyl peptidase 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07187","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the downregulation of genes that enable dipeptidyl-peptidase activity. In a study ... | |
medium_hidden_intermediate_07189 | Human alphaherpesvirus 3 upregulates a gene that is involved in the type III interferon-mediated signaling pathway. Experimental data from a melanoma cell line (study GSE136586) indicates that this specific gene has a log2 fold change of 3.686 and an adjusted p-value of 2.169e-08. Which protein is encoded by this gene? | Interferon lambda-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07189","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that is involved in the type III interferon-mediated signaling pathway. Experime... | |
medium_hidden_intermediate_07191 | Measles morbillivirus downregulates a gene that participates in chromatin modifying enzymes. Evidence for one such gene reports a log2 fold change of -1.088 and an adjusted p-value of 0.004435. Which protein is encoded by that gene? | Elongator complex protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07191","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that participates in chromatin modifying enzymes. Evidence for one such gene repo... | |
medium_hidden_intermediate_07193 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its product interacts with RPA3. Experimental data for this gene reports a log2 fold change of approximately 1.297 and an adjusted p-value of 0.04527. Which protein is encoded by this gene? | RNA-binding protein 25 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07193","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its product interacts with RP... | |
medium_hidden_intermediate_07194 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of the fibroblast apoptotic process. Evidence for this gene reports a log2 fold change of 2.413 and an adjusted p-value of 0.001148. Which protein is encoded by this gene? | Protein BTG1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07194","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of the ... | |
medium_hidden_intermediate_07195 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that subsequently binds to STAT1. Experimental data for one such gene reports a log2 fold change of approximately 1.205 and an adjusted p-value of 0.03249. Which protein is encoded by this specific gene? | Hsc70-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07195","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that subsequently binds to STAT1. Experimental data... | |
medium_hidden_intermediate_07197 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a gene is upregulated and enables RNA nuclease activity. Evidence for this gene reports a log2 fold change of 1.467 and an adjusted p-value of 0.02378. Which protein is encoded by this gene? | Ribonuclease K6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07197","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a gene is upregulated and enables RNA nucleas... | |
medium_hidden_intermediate_07200 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in SARS-CoV Infections. Experimental evidence for this gene reports a log2 fold change of approximately 2.94 and an adjusted p-value of approximately 0.0068. Which cellular component is this gene located in? | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07200","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in SARS-CoV Infections. Expe... | |
medium_hidden_intermediate_07202 | A gene is linked to Natural killer T (NKT) cells via a 'has marker' relationship and to UBE2M via an 'interacts with' relationship. Evidence regarding one such gene states: 'We report that the family of human DCN-like (DCNL) co-E3s, which promote ligation of the ubiquitin-like protein NEDD8 to cullin targets, recognize... | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07202","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is linked to Natural killer T (NKT) cells via a 'has marker' relationship and to UBE2M via an 'interacts with' relati... | |
medium_hidden_intermediate_07203 | Human betaherpesvirus 5 upregulates a gene that is enriched in intermediate monocytes. Evidence for this gene in foreskin fibroblast cell lines (study GSE132081) reports a log2 fold change of approximately 2.09 and an adjusted p-value of approximately 0.0013. Which protein is encoded by this gene? | Golgi-associated kinase 1B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07203","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is enriched in intermediate monocytes. Evidence for this gene in foreskin fi... | |
medium_hidden_intermediate_07204 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with PACSIN1. One of these genes was reported in a study on sclera cells with a log2 fold change of approximately 1.128 and an adjusted p-value of 0.003294. Which protein is encoded by this specific gene? | Protein kinase C and casein kinase substrate in neurons protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07204","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with PACSIN1. One of these g... | |
medium_hidden_intermediate_07208 | Human alphaherpesvirus 1 upregulates a gene that interacts with CEP135. In a study of monocytic leukemia cell lines (GSE114966), one such upregulated gene showed a log2 fold change of 1.488 and an adjusted p-value of 0.01838. Which protein is encoded by this specific gene? | Rotatin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07208","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that interacts with CEP135. In a study of monocytic leukemia cell lines (GSE1149... | |
medium_hidden_intermediate_07212 | Zika virus downregulates a specific gene, which in turn binds to EXOSC7. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.278 and an adjusted p-value of 0.002981. Which protein is encoded by this gene? | Exosome complex exonuclease RRP44 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07212","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn binds to EXOSC7. Experimental data for this gene in glioma stem cell... | |
medium_hidden_intermediate_07213 | Human immunodeficiency virus 1 upregulates a gene that participates in the RHOA GTPase cycle. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately 1.137 and an adjusted p-value of 0.000617. Which biological process is this gene involved in? | neuronal signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07213","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the RHOA GTPase cycle. In a study of macrophages (GSE... | |
medium_hidden_intermediate_07214 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is downregulated by Vaccinia virus and binds to KAT2A. This specific gene exhibits a log2 fold change of approximately -1.21 and an adjusted p-value of approximately 0.0019. Which protein is encoded by this gene? | Ataxin-7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07214","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is downregulated by Vaccinia virus and binds to KAT2A. T... | |
medium_hidden_intermediate_07215 | Two genes are upregulated by Measles morbillivirus and interact with TOP3B. One of these genes has a reported log2 fold change of 1.332 and an adjusted p-value of 0.0003758 in study GSE131840. Which disease is associated with this specific gene as a biomarker? | diffuse large B-cell lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07215","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Measles morbillivirus and interact with TOP3B. One of these genes has a reported log2 fold chan... | |
medium_hidden_intermediate_07216 | Enterovirus A is reported to downregulate a specific gene, which is subsequently found to be located in extracellular exosomes. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) indicates a log2 fold change of approximately -1.069 and an adjusted p-value of 0.02996. Which disease is associated... | pituitary gigantism | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07216","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a specific gene, which is subsequently found to be located in extracellular exosom... | |
medium_hidden_intermediate_07217 | Zika virus infection is associated with the downregulation of genes that enable protein disulfide isomerase activity. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.844 and an adjusted p-value of 0.03313. Which protein is encoded by this specific gene? | Protein disulfide-isomerase A5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07217","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection is associated with the downregulation of genes that enable protein disulfide isomerase activity. In a s... | |
medium_hidden_intermediate_07219 | Human immunodeficiency virus 1 upregulates a gene that is associated with carcinoma. In a study of macrophages (GSE108897), this gene exhibits a log2 fold change of approximately 1.955 and an adjusted p-value of approximately 0.0006665. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07219","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is associated with carcinoma. In a study of macrophages (GSE108897), ... | |
medium_hidden_intermediate_07220 | Zika virus downregulates a gene that is located in the membrane raft. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of approximately -1.43 and an adjusted p-value of approximately 0.041. Which protein is encoded by this specific gene? | Myeloid-associated differentiation marker | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07220","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the membrane raft. In a study of glioma stem cells (GSE114907), one such ... | |
medium_hidden_intermediate_07221 | In a study of pleural mesothelioma cells (GSE117668), a gene is upregulated by Measles morbillivirus and enriched in intermediate monocytes. This gene exhibits a log2 fold change of approximately 1.053 and an adjusted p-value of 0.001022. Which protein is encoded by this gene? | Equilibrative nucleobase transporter 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07221","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), a gene is upregulated by Measles morbillivirus and enriched in interme... | |
medium_hidden_intermediate_07223 | Human betaherpesvirus 5 is reported to downregulate a specific gene, which is subsequently involved in the negative regulation of transcription by RNA polymerase II. Experimental data for this gene in foreskin fibroblast cell lines indicates a log2 fold change of approximately -1.42 and an adjusted p-value of approxima... | endometriosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07223","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a specific gene, which is subsequently involved in the negative regulati... | |
medium_hidden_intermediate_07224 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to positive regulation of canonical NF-kappaB signal transduction via an 'involved in' relationship. One of these genes is reported in study GSE108897 (macrophages) with a log2 fold change of -1.845 and an adjuste... | lupus vulgaris | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07224","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to positive regul... | |
medium_hidden_intermediate_07226 | Hepacivirus C upregulates a gene that is involved in the leukotriene metabolic process. Evidence for one such gene reports a log2 fold change of 1.914 and an adjusted p-value of 0.003924. Which protein is encoded by that gene? | ATP-binding cassette sub-family C member 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07226","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the leukotriene metabolic process. Evidence for one such gene reports a... | |
medium_hidden_intermediate_07227 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with SUCLG2. Evidence for one such gene reports a log2 fold change of 1.455 and an adjusted p-value of 0.04606. Which biological process is that gene involved in? | glyceraldehyde-3-phosphate biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07227","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with SUCLG2. Evidence for one such g... | |
medium_hidden_intermediate_07228 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn interacts with MATR3. The downregulation of this gene is characterized by a log2 fold change of approximately -1.45 and an adjusted p-value of 0.01325. Which protein is enc... | Zinc finger protein 638 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07228","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_07229 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in reciprocal meiotic recombination. Evidence for this gene reports a log2 fold change of approximately 1.056 and an adjusted p-value of 0.01268. Which gene interacts with this entity? | RAD51 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07229","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in reciprocal meiotic recombi... | |
medium_hidden_intermediate_07230 | Hepacivirus C is reported to downregulate a gene that participates in the Innate Immune System. Experimental data for one such gene shows a log2 fold change of -1.506 and an adjusted p-value of 0.0001191. Which protein is encoded by this gene? | Adhesion G protein-coupled receptor E3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07230","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that participates in the Innate Immune System. Experimental data for one su... | |
medium_hidden_intermediate_07232 | Two genes are structurally linked to Vaccinia virus via a downregulation relationship and to prostate cancer via an association relationship. One of these genes exhibits a log2 fold change of approximately -1.038 and an adjusted p-value of 0.001155 in a specific study context. Which protein is encoded by the gene match... | Proprotein convertase subtilisin/kexin type 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07232","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Vaccinia virus via a downregulation relationship and to prostate cancer via an associat... | |
medium_hidden_intermediate_07233 | Two genes are upregulated by Vaccinia virus and participate in G1/S-Specific Transcription. One of these genes shows a log2 fold change of 3.508 and an adjusted p-value of 1.186e-07 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene as a biomarker? | lung neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07233","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in G1/S-Specific Transcription. One of these genes shows a log2 ... | |
medium_hidden_intermediate_07234 | Two genes are downregulated by Pegivirus C and interact with YWHAZ. One of these genes exhibits a log2 fold change of -1.696 and an adjusted p-value of 0.0004147 in peripheral blood mononuclear cells. Which cellular component is the location of this specific gene? | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07234","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and interact with YWHAZ. One of these genes exhibits a log2 fold change of -1.696... | |
medium_hidden_intermediate_07235 | Zika virus downregulates a gene that participates in the mitotic cell cycle. Evidence for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -4.052 and an adjusted p-value of 0.001455. Which disease is associated with this gene? | colon carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07235","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the mitotic cell cycle. Evidence for this gene in glioma stem cells (st... | |
medium_hidden_intermediate_07236 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate certain genes located in the endoplasmic reticulum membrane. One such gene exhibited a log2 fold change of approximately -1.036 and an adjusted p-value of 0.0003242. Which protein does this specific gene product interact wit... | FBXO6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07236","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate certain genes located in the... | |
medium_hidden_intermediate_07237 | Pegivirus C downregulates a gene that participates in Coenzyme A biosynthesis. Evidence for this gene in peripheral blood mononuclear cells (study GSE131504) reports a log2 fold change of -1.279 and an adjusted p-value of 0.002794. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07237","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in Coenzyme A biosynthesis. Evidence for this gene in peripheral blood mo... | |
medium_hidden_intermediate_07239 | Human immunodeficiency virus 1 upregulates a gene that participates in Intra-Golgi traffic. In a study of macrophages (GSE108897), one such gene showed a log2 fold change of approximately 1.225 and an adjusted p-value of 0.001829. Which protein is encoded by this specific gene? | Alpha-mannosidase 2x | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07239","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in Intra-Golgi traffic. In a study of macrophages (GSE10... | |
medium_hidden_intermediate_07240 | Rhinovirus A is known to upregulate certain genes that are enriched in mucosa-associated invariant T (MAIT) cells. One such gene exhibits a log2 fold change of 1.019 and an adjusted p-value of 0.002429 in cytotoxic T-lymphocytes (study GSE106475). Which disease is associated with this specific gene as a biomarker? | hypercalcemia disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07240","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A is known to upregulate certain genes that are enriched in mucosa-associated invariant T (MAIT) cells. One such ... | |
medium_hidden_intermediate_07242 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of telomere maintenance. Evidence for this gene reports a log2 fold change of 1.432 and an adjusted p-value of 0.006499. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07242","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of telo... | |
medium_hidden_intermediate_07243 | Pegivirus C downregulates a gene that participates in Class I MHC mediated antigen processing & presentation. Evidence for this gene in peripheral blood mononuclear cells (study GSE131504) reports a log2 fold change of -1.465 and an adjusted p-value of 0.00153. Which protein is encoded by this gene? | Apoptosis-resistant E3 ubiquitin protein ligase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07243","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in Class I MHC mediated antigen processing & presentation. Evidence for t... | |
medium_hidden_intermediate_07244 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in SARS-CoV Infections. Transcriptomic data for this gene reports a log2 fold change of approximately 2.94 and an adjusted p-value of 0.0068. Which protein is encoded by this gene? | Palmitoyltransferase ZDHHC11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07244","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in SARS-CoV Infections. Tran... | |
medium_hidden_intermediate_07245 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in glutamate binding, activation of AMPA receptors, and synaptic plasticity. One such gene exhibits a log2 fold change of 1.586 and an adjusted p-value of 2.405e-05. Which protein is encoded by this specific gene? | PRKCA-binding protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07245","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in glutamate bind... | |
medium_hidden_intermediate_07246 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with HIST1H4A. One of these genes shows a log2 fold change of 1.003 and an adjusted p-value of 0.01752 in a specific study. Which protein is encoded by this gene? | Deoxynucleotidyltransferase terminal-interacting protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07246","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with HIST1H4A. One of these ... | |
medium_hidden_intermediate_07247 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of these genes exhibits a log2 fold change of 1.878 and an adjusted p-value of 6.328e-08 in a specific study. Which disease is linked to this specific gene through genomic alterations? | adenoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07247","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of th... | |
medium_hidden_intermediate_07250 | Measles morbillivirus downregulates a specific gene product that is subsequently found within extracellular exosomes. Experimental data for this entity indicates a log2 fold change of approximately -1.000 and an adjusted p-value of 0.0001942. Which biological process is this entity involved in? | cytoskeleton organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07250","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a specific gene product that is subsequently found within extracellular exosomes. Experi... | |
medium_hidden_intermediate_07251 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables tRNA binding. Experimental data for this gene shows a log2 fold change of 1.486 and an adjusted p-value of 0.006671. Which biological process is this gene involved in? | wybutosine biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07251","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables tRNA binding. Experimental data f... | |
medium_hidden_intermediate_07253 | Human alphaherpesvirus 1 is known to downregulate certain genes whose products are located in extracellular exosomes. One such gene exhibits a log2 fold change of approximately -1.034 and an adjusted p-value of 0.008914 in a monocytic leukemia cell line study. Which protein is encoded by this specific gene? | BEN domain-containing protein 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07253","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 is known to downregulate certain genes whose products are located in extracellular exosomes. One su... | |
medium_hidden_intermediate_07254 | Two genes are downregulated by Pegivirus C and are involved in the positive regulation of canonical NF-kappaB signal transduction. One of these genes exhibits a log2 fold change of -1.628 and an adjusted p-value of 0.002132 in peripheral blood mononuclear cells. Which disease is associated with this specific gene as a ... | ovarian neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07254","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and are involved in the positive regulation of canonical NF-kappaB signal transdu... | |
medium_hidden_intermediate_07255 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Biological oxidations. Evidence for this gene reports a log2 fold change of -1.159 and an adjusted p-value of 0.001277. Which disease is associated with this gene as a biomarker? | stroke disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07255","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Biological oxidations. ... | |
medium_hidden_intermediate_07256 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with PRNP. One of these genes was reported in a study (GSE164073) involving sclera cells, with a log2 fold change of 2.265 and an adjusted p-value of 0.03133. Which disease is associated with this specific gene? | sarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07256","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with PRNP. One of these gene... | |
medium_hidden_intermediate_07257 | Zika virus downregulates a gene that is involved in nervous system development. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of approximately -2.25 and an adjusted p-value of approximately 0.0052. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07257","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in nervous system development. In a study of glioma stem cells (GSE114907),... | |
medium_hidden_intermediate_07258 | AP1B1 interacts with a protein that is enriched in basophils. Experimental evidence indicates that this protein, when recombinantly expressed, interacts directly with the gamma-appendage domain of AP-1, the clathrin N-terminal domain via the peptide motif (423)LFDLM, the gamma-adaptin ear homology domain of Golgi-local... | Clathrin interactor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07258","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"AP1B1 interacts with a protein that is enriched in basophils. Experimental evidence indicates that this protein, when recomb... | |
medium_hidden_intermediate_07259 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the execution phase of apoptosis. Evidence for one such gene reports a log2 fold change of 1.311 and an adjusted p-value of 0.001198. Which protein is encoded by that gene? | Lipid transferase CIDEB | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07259","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the execution phase of apoptosi... | |
medium_hidden_intermediate_07261 | Two genes are each downregulated by Vaccinia virus and associated with lymphoma. One of these genes exhibits a log2 fold change of -2.377 and an adjusted p-value of 0.0106 in cervical adenocarcinoma cell lines. Which protein interacts with this specific gene? | PCGF1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07261","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Vaccinia virus and associated with lymphoma. One of these genes exhibits a log2 fold cha... | |
medium_hidden_intermediate_07262 | Hepacivirus C is reported to downregulate a specific gene, which is in turn enriched in naive CD8+ T cells. Transcriptomic data for this gene in natural killer cells from study GSE125686 shows a log2 fold change of -1.011 and an adjusted p-value of 0.0005217. Which protein is encoded by this gene? | Plexin domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07262","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which is in turn enriched in naive CD8+ T cells. Transcriptomic d... | |
medium_hidden_intermediate_07263 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with RPA1. Evidence for one such gene reports a log2 fold change of 1.264 and an adjusted p-value of 0.01057. Which protein is encoded by that gene? | Zinc finger-containing ubiquitin peptidase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07263","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with RPA1. Evidence for one such gen... | |
medium_hidden_intermediate_07264 | A gene is downregulated by Enterovirus A and participates in Neutrophil degranulation. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of -1.605 and an adjusted p-value of 0.002109. Which disease is associated with this gene as a biomarker? | lung neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07264","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Enterovirus A and participates in Neutrophil degranulation. Experimental data for this gene in rh... | |
medium_hidden_intermediate_07265 | Zika virus downregulates a gene that interacts with ACTC1. In glioma stem cells, one such gene exhibits a log2 fold change of approximately -1.566 and an adjusted p-value of 0.001455. Which protein is encoded by this gene? | Tropomodulin-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07265","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with ACTC1. In glioma stem cells, one such gene exhibits a log2 fold change o... | |
medium_hidden_intermediate_07267 | A gene is upregulated by Primate bocaparvovirus 1 and is involved in the immune response. Experimental data for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of 3.359 and an adjusted p-value of 0.04936. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07267","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is involved in the immune response. Experimental data for this gene in... | |
medium_hidden_intermediate_07270 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in G alpha (i) signalling events. One of these genes exhibits a log2 fold change of -1.404 and an adjusted p-value of 0.001424 in a specific study. Which cell type is enriched for this specific gene? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07270","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in G alpha (i) signalli... | |
medium_hidden_intermediate_07271 | Human betaherpesvirus 5 downregulates a gene that interacts with MYC. Experimental data for this gene in foreskin fibroblast cell lines (study GSE130665) reports a log2 fold change of -1.386 and an adjusted p-value of 1.67e-05. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07271","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that interacts with MYC. Experimental data for this gene in foreskin fibroblast... | |
medium_hidden_intermediate_07272 | Vaccinia virus upregulates a gene that is involved in protein modification processes. Evidence for one such gene reports a log2 fold change of 1.460 and an adjusted p-value of 0.004438. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07272","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that is involved in protein modification processes. Evidence for one such gene reports a l... | |
medium_hidden_intermediate_07273 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with inborn error of immunity. Experimental data for this gene reports a log2 fold change of -2.662 and an adjusted p-value of 0.01984. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07273","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with inborn error of immu... | |
medium_hidden_intermediate_07274 | Human betaherpesvirus 5 is known to downregulate certain genes that participate in peptide ligand-binding receptors. One such gene exhibits a log2 fold change of -5.171 and an adjusted p-value of 0.003922 in foreskin fibroblast cell lines (study GSE132081). Which disease is associated with this specific gene as a bioma... | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07274","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate certain genes that participate in peptide ligand-binding receptors. One suc... | |
medium_hidden_intermediate_07276 | Hepacivirus C is reported to downregulate a specific gene, which is subsequently found to be enriched in naive CD8+ T cells. Experimental data for this gene indicates a log2 fold change of approximately -1.009 and an adjusted p-value of 0.02802. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07276","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which is subsequently found to be enriched in naive CD8+ T cells.... | |
medium_hidden_intermediate_07278 | Zika virus downregulates a specific gene, which in turn binds to WDR26. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.486 and an adjusted p-value of 0.006352. Which protein is encoded by this gene? | Glucose-induced degradation protein 8 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07278","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn binds to WDR26. Experimental data for this gene in glioma stem cells... | |
medium_hidden_intermediate_07279 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to ischemic stroke via an 'associated with' relationship. One of these genes is reported in a study (GSE150819) involving bronchial epithelial cells, with a log2 fold change of -2.360 and an... | NEDD4 family-interacting protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07279","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_07281 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and participates in phospholipid metabolism. This gene exhibits a log2 fold change of approximately 1.23 and an adjusted p-value of approximately 2.42e-10. Which protein is encoded by this gene? | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07281","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and p... | |
medium_hidden_intermediate_07282 | Human mastadenovirus C upregulates a gene that is located in the cytoplasm. In a study of lung fibroblast cell lines (GSE120891), this gene exhibited a log2 fold change of approximately 1.16 and an adjusted p-value of approximately 0.038. Which disease is associated with this gene? | hypogonadotropic hypogonadism 7 with or without anosmia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07282","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human mastadenovirus C upregulates a gene that is located in the cytoplasm. In a study of lung fibroblast cell lines (GSE120... | |
medium_hidden_intermediate_07284 | Zika virus infection leads to the downregulation of certain genes that are involved in the response to UV radiation. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -1.92 and an adjusted p-value of 0.026. Which protein is encoded by this specific gene? | DNA annealing helicase and endonuclease ZRANB3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07284","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of certain genes that are involved in the response to UV radiation. In a st... | |
medium_hidden_intermediate_07285 | Human betaherpesvirus 5 is reported to upregulate a gene that participates in Signal Transduction. Experimental data for this gene shows a log2 fold change of approximately 3.09 and an adjusted p-value of 0.023. Which protein is encoded by this gene? | C3a anaphylatoxin chemotactic receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07285","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that participates in Signal Transduction. Experimental data for thi... | |
medium_hidden_intermediate_07286 | Zaire ebolavirus infection has been linked to the downregulation of specific genes, which are in turn associated with squamous cell carcinoma. In a study of retinal pigment epithelium cells (GSE100839), one such gene exhibited a log2 fold change of -1.201 and an adjusted p-value of 0.005648. Which protein is encoded by... | Adenosine receptor A2b | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07286","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection has been linked to the downregulation of specific genes, which are in turn associated with squamo... | |
medium_hidden_intermediate_07288 | Two genes are structurally linked to Cardiovirus A via downregulation and to the sperm midpiece via location. One of these genes exhibits a log2 fold change of approximately -1.013 and an adjusted p-value of 0.03695 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene? | spermatogenic failure 24 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07288","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via downregulation and to the sperm midpiece via location. One of these g... | |
medium_hidden_intermediate_07290 | Human betaherpesvirus 5 downregulates a gene that participates in O-linked glycosylation of mucins. Evidence for this gene reports a log2 fold change of -1.024 and an adjusted p-value of 3.007e-09. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07290","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that participates in O-linked glycosylation of mucins. Evidence for this gene r... | |
medium_hidden_intermediate_07291 | Vaccinia virus downregulates a gene that is involved in spermatogenesis. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of approximately -1.52 and an adjusted p-value of 0.0116. Which protein is encoded by this gene? | Cation channel sperm-associated protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07291","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene that is involved in spermatogenesis. Experimental data from a cervical adenocarcinoma ce... |
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