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medium_hidden_intermediate_07292 | In a study of glioblastoma multiforme cancer stem cells (GSE102924), Zika virus upregulates certain genes that are subsequently found in extracellular exosomes. One such gene exhibits a log2 fold change of 1.886 and an adjusted p-value of 0.03229. Which biological process is this specific gene involved in? | positive regulation of DNA-templated transcription | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07292","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioblastoma multiforme cancer stem cells (GSE102924), Zika virus upregulates certain genes that are subsequen... | |
medium_hidden_intermediate_07294 | Human betaherpesvirus 5 is linked to epilepsy via an intermediate gene that it upregulates, which is in turn associated with the condition. One such intermediate gene exhibits a log2 fold change of 2.332 and an adjusted p-value of 0.0003401 in a specific study. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07294","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is linked to epilepsy via an intermediate gene that it upregulates, which is in turn associated with... | |
medium_hidden_intermediate_07295 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to UBB via a 'binds' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 1.085 and an adjusted p-value of 0.01425. Which gene int... | UBE2L6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07295","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_07296 | Zika virus downregulates a gene that is located in the mitochondrial membrane. Evidence for this specific gene reports a log2 fold change of -2.415 and an adjusted p-value of 0.01368. Which protein is encoded by this gene? | Acyl-CoA dehydrogenase family member 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07296","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the mitochondrial membrane. Evidence for this specific gene reports a log... | |
medium_hidden_intermediate_07297 | Zika virus downregulates a specific gene that is involved in the positive regulation of the canonical Wnt signaling pathway. Experimental data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of approximately -1.24 and an adjusted p-value of approximately 0.023. Which disease is ... | leukodystrophy, hypomyelinating, 23, with ataxia, deafness, liver dysfunction, and dilated cardiomyopathy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07297","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the positive regulation of the canonical Wnt signaling pathway.... | |
medium_hidden_intermediate_07300 | A gene is upregulated by Primate bocaparvovirus 1 and enables identical protein binding. Experimental data for this gene in tracheobronchial epithelial cells (study GSE102392) reports a log2 fold change of approximately 1.11 and an adjusted p-value of approximately 0.00014. Which protein is encoded by this gene? | Protein DDI1 homolog 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07300","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and enables identical protein binding. Experimental data for this gene in ... | |
medium_hidden_intermediate_07301 | Rhinovirus A infection leads to the downregulation of specific genes that participate in 'Signaling by Rho GTPases, Miro GTPases and RHOBTB3'. In a study of cytotoxic T-lymphocytes (GSE106475), one such downregulated gene exhibited a log2 fold change of -1.983 and an adjusted p-value of 0.0004407. Which protein is enco... | FYVE, RhoGEF and PH domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07301","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of specific genes that participate in 'Signaling by Rho GTPases, Miro GTP... | |
medium_hidden_intermediate_07303 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and its product is located in the axonemal microtubule. Evidence for this gene reports a log2 fold change of 4.152 and an adjusted p-value of 0.007529. Which protein is encoded by this gene? | Cilia- and flagella-associated protein 161 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07303","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and its product is located in the axonemal mi... | |
medium_hidden_intermediate_07304 | Zaire ebolavirus downregulates a gene that is involved in leukocyte chemotaxis. In a study of retinal pigment epithelium cells (GSE100839), this gene exhibited a log2 fold change of approximately -1.606 and an adjusted p-value of 0.0195. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07304","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that is involved in leukocyte chemotaxis. In a study of retinal pigment epithelium cel... | |
medium_hidden_intermediate_07307 | Human immunodeficiency virus 1 upregulates a gene that is involved in the negative regulation of inflammatory response. Evidence for this specific gene reports a log2 fold change of 1.584 and an adjusted p-value of 0.008217. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07307","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the negative regulation of inflammatory response. Evid... | |
medium_hidden_intermediate_07308 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that enables glycerophospholipase activity. This specific gene exhibited a log2 fold change of 1.758 and an adjusted p-value of 0.02521. Which protein is encoded by this gene? | Lysosomal leucine aminopeptidase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07308","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that enables glycer... | |
medium_hidden_intermediate_07311 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with SLC25A46. One of these genes shows a log2 fold change of 1.348 and an adjusted p-value of 9.93e-16 in a specific study. Which protein is encoded by this gene? | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07311","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with SLC25A46. One of these ... | |
medium_hidden_intermediate_07312 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to ureteral obstruction via an association relationship. One of these genes was reported in a study using a pancreatic cell line (GSE151803) with a log2 fold change of approximately 2.398 and an adjusted p... | Receptor activity-modifying protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07312","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to ureter... | |
medium_hidden_intermediate_07313 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate specific genes that participate in Class I MHC mediated antigen processing & presentation. One such gene exhibited a log2 fold change of approximately 2.50 and an adjusted p-value of 0.03. Which biological process is this ... | protein ubiquitination | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07313","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate specific genes that partic... | |
medium_hidden_intermediate_07315 | Rhinovirus A infection leads to the downregulation of certain genes that are enriched in plasmacytoid dendritic cells. One such gene exhibits a log2 fold change of -1.275 and an adjusted p-value of 0.01427 in cytotoxic T-lymphocytes. Which protein is encoded by this specific gene? | Exostosin-like 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07315","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of certain genes that are enriched in plasmacytoid dendritic cells. One s... | |
medium_hidden_intermediate_07316 | Zaire ebolavirus upregulates a gene that is enriched in basophils. Evidence for this specific gene reports a log2 fold change of 1.323 and an adjusted p-value of 0.0164. Which protein is encoded by this gene? | Reticulophagy regulator 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07316","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that is enriched in basophils. Evidence for this specific gene reports a log2 fold chang... | |
medium_hidden_intermediate_07317 | In a study of non-small cell lung adenocarcinoma cell lines infected with Influenza A virus, a specific gene was found to be upregulated and localized to the mitochondrion. This gene exhibited a log2 fold change of approximately 1.04 and an adjusted p-value of 2.129e-09. Which disease is associated with genomic alterat... | infantile spasms | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07317","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines infected with Influenza A virus, a specific gene was found to be... | |
medium_hidden_intermediate_07319 | In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and serving as a biomarker for major depressive disorder. This specific gene exhibits a log2 fold change of approximately -1.070 and an adjusted p-value of 0.0008965. Which protein is encoded by this gen... | Glycosyltransferase 8 domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07319","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and ser... | |
medium_hidden_intermediate_07321 | Zaire ebolavirus downregulates a gene that is located on the cell surface. In a study of retinal pigment epithelium cells (GSE100839), one such downregulated gene exhibited a log2 fold change of -1.322 and an adjusted p-value of 0.04602. Which protein is encoded by this specific gene? | Cell surface glycoprotein CD200 receptor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07321","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that is located on the cell surface. In a study of retinal pigment epithelium cells (G... | |
medium_hidden_intermediate_07323 | A gene serves as a marker for Astrocytes and is enriched in Non-classical monocytes. Evidence for this gene includes a mean expression of 88.21 TPM, a z-score of 2.16, and a fold enrichment of 3.74. Which protein does this gene product interact with? | SQSTM1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07323","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Astrocytes and is enriched in Non-classical monocytes. Evidence for this gene includes a mean ... | |
medium_hidden_intermediate_07325 | Rift Valley fever phlebovirus upregulates a gene that is located in the P-body. Evidence for this specific gene reports a log2 fold change of 1.837 and an adjusted p-value of 0.001102. Which protein is encoded by this gene? | Shiftless antiviral inhibitor of ribosomal frameshifting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07325","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rift Valley fever phlebovirus upregulates a gene that is located in the P-body. Evidence for this specific gene reports a lo... | |
medium_hidden_intermediate_07326 | In a study of Measles morbillivirus infection, multiple genes are upregulated and localized to the postsynapse. One such gene exhibits a log2 fold change of 1.934 and an adjusted p-value of 0.02242. Which protein is encoded by this specific gene? | Switch-associated protein 70 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07326","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, multiple genes are upregulated and localized to the postsynapse. One such gen... | |
medium_hidden_intermediate_07327 | Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of pyruvate decarboxylation to acetyl-CoA. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.808 and an adjusted p-value of 0.03823. Which protein is encoded by this sp... | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07327","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of pyruvate decarboxylation to ac... | |
medium_hidden_intermediate_07328 | Enterovirus A upregulates a gene that enables transcription corepressor activity. Evidence for one such gene reports a log2 fold change of 1.951 and an adjusted p-value of 0.002021. Which cell type is this gene enriched in? | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07328","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that enables transcription corepressor activity. Evidence for one such gene reports a log2 ... | |
medium_hidden_intermediate_07329 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is identified as being downregulated by the virus and participating in the translation of structural proteins. Experimental data for this gene reports a log2 fold change of -1.147 and an adjusted p-value of 0.03857. Which pro... | Protein mono-ADP-ribosyltransferase PARP6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07329","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is identified as being downre... | |
medium_hidden_intermediate_07330 | A gene is downregulated by Primate bocaparvovirus 1 and its product binds to ZWINT. Experimental data for this gene shows a log2 fold change of -1.866 and an adjusted p-value of 0.008247. Which protein is encoded by this gene? | Centromere protein P | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07330","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and its product binds to ZWINT. Experimental data for this gene shows a ... | |
medium_hidden_intermediate_07331 | Human immunodeficiency virus 1 upregulates a gene that is involved in protein monoubiquitination. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately 1.089 and an adjusted p-value of 0.004599. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase RNF152 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07331","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in protein monoubiquitination. In a study of macrophages ... | |
medium_hidden_intermediate_07332 | Zika virus downregulates a specific gene that is involved in muscle cell differentiation. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.48 and an adjusted p-value of approximately 0.037. Which cellular component is this gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07332","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in muscle cell differentiation. Experimental data for this gene in... | |
medium_hidden_intermediate_07333 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which is associated with disease. This gene exhibited a log2 fold change of approximately 1.215 and an adjusted p-value of 5.184e-06. Which biological process is this gene involved in? | protein maturation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07333","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_07334 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables serine-type peptidase activity. Experimental data for this gene reports a log2 fold change of 1.105 and an adjusted p-value of 0.03852. Which biological process is this gene involved in? | proteolysis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07334","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables serine-type peptidase activity. E... | |
medium_hidden_intermediate_07335 | Zika virus downregulates a specific gene that participates in Cytokine Signaling in the Immune system. Experimental data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of -2.765 and an adjusted p-value of 0.006497. Which biological process is this gene involved in? | interstrand cross-link repair | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07335","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in Cytokine Signaling in the Immune system. Experimental data fro... | |
medium_hidden_intermediate_07336 | Human immunodeficiency virus 1 is known to downregulate certain genes that are associated with myeloid leukemia. One such gene exhibits a log2 fold change of -2.050 and an adjusted p-value of 0.0001021 in macrophages (study GSE108897). Which protein is encoded by this specific gene? | Twisted gastrulation protein homolog 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07336","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 is known to downregulate certain genes that are associated with myeloid leukemia. One such ge... | |
medium_hidden_intermediate_07337 | Zika virus downregulates a specific gene, which in turn interacts with RAB11A. Experimental data for this gene shows a log2 fold change of -1.875 and an adjusted p-value of 0.002997. In which cell type is this gene enriched? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07337","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with RAB11A. Experimental data for this gene shows a log2 ... | |
medium_hidden_intermediate_07339 | Pegivirus C is reported to downregulate a gene that is involved in protein farnesylation. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -2.19 and an adjusted p-value of 0.001157. Which protein is encoded by this specific gene? | Protein farnesyltransferase subunit beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07339","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in protein farnesylation. In a study of peripheral blood mon... | |
medium_hidden_intermediate_07340 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in retrograde transport from endosome to Golgi. One of these genes shows a log2 fold change of 1.306 and an adjusted p-value of 0.003735 in choroid plexus epithelium. Which disease is associated with this specific gene a... | intellectual disability | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07340","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in retrograde transport ... | |
medium_hidden_intermediate_07342 | Zika virus downregulates a gene that interacts with UBE2I. In glioma stem cells (study GSE114907), one such gene exhibits a log2 fold change of -1.080 and an adjusted p-value of 0.0101. Which protein is encoded by this gene? | SUMO-activating enzyme subunit 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07342","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with UBE2I. In glioma stem cells (study GSE114907), one such gene exhibits a ... | |
medium_hidden_intermediate_07344 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and localized to the late endosome membrane. This gene exhibits a log2 fold change of approximately 1.015 and an adjusted p-value of 0.009509. Which protein does this gene product interact... | GLP1R | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07344","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_07345 | Human betaherpesvirus 5 is reported to upregulate a specific gene, which is in turn enriched in peripheral blood mononuclear cells (PBMCs). Experimental data for this gene shows a log2 fold change of approximately 1.302 and an adjusted p-value of 0.03284. Which protein is encoded by this gene? | Endothelial cell-selective adhesion molecule | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07345","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a specific gene, which is in turn enriched in peripheral blood mononuclear... | |
medium_hidden_intermediate_07347 | Two genes are upregulated by Enterovirus A and both enable sequence-specific DNA binding. One of these genes was reported in a study (GSE103308) on rhabdomyosarcoma cells with a log2 fold change of approximately 1.068 and an adjusted p-value of 0.003729. Which disease is associated with this specific gene? | myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07347","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Enterovirus A and both enable sequence-specific DNA binding. One of these genes was reported in... | |
medium_hidden_intermediate_07348 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and participates in SARS-CoV-2 infection. This specific gene exhibits a log2 fold change of -1.980 and an adjusted p-value of 0.01515. Which protein is encoded by this gene? | Protein mono-ADP-ribosyltransferase PARP14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07348","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and participates in SAR... | |
medium_hidden_intermediate_07349 | In a study of Influenza A virus infection, a specific gene is downregulated by the virus and participates in RNA Polymerase II transcription. Evidence for this gene reports a log2 fold change of -1.175 and an adjusted p-value of 0.0002312. Which protein is encoded by this gene? | Zinc finger protein 521 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07349","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is downregulated by the virus and participates in RNA Polymerase ... | |
medium_hidden_intermediate_07350 | In a study of lung fibroblasts (GSE120891), Human mastadenovirus C was found to downregulate a specific gene, which in turn enables protein binding. This gene exhibited a log2 fold change of approximately -1.22 and an adjusted p-value of 0.038. Which biological process is this gene involved in? | endothelial cell migration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07350","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung fibroblasts (GSE120891), Human mastadenovirus C was found to downregulate a specific gene, which in turn ... | |
medium_hidden_intermediate_07351 | In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and enriched in intermediate monocytes. One of these genes exhibits a log2 fold change of approximately 1.769 and an adjusted p-value of 0.004895. Which cellular component is the protein product of this specific ge... | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07351","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and enriched in in... | |
medium_hidden_intermediate_07352 | Human betaherpesvirus 5 is reported to downregulate a gene that is involved in cell adhesion. In a study using foreskin fibroblast cell lines, one such gene exhibited a log2 fold change of -1.509 and an adjusted p-value of 0.044. Which protein is encoded by this specific gene? | Testican-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07352","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is involved in cell adhesion. In a study using foreskin fibr... | |
medium_hidden_intermediate_07354 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes involved in the positive regulation of cell population proliferation. One such gene exhibited a log2 fold change of 2.278 and an adjusted p-value of 3.165e-07. Which protein interacts with this s... | BTAF1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07354","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... | |
medium_hidden_intermediate_07355 | Pegivirus C is reported to downregulate a gene that subsequently binds to RPS8. In a study of peripheral blood mononuclear cells (GSE131504), one such intermediate gene exhibited a log2 fold change of approximately -1.50 and an adjusted p-value of approximately 0.01. Which protein is encoded by this specific intermedia... | Stalled ribosome sensor GCN1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07355","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that subsequently binds to RPS8. In a study of peripheral blood mononuclear c... | |
medium_hidden_intermediate_07356 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified as being downregulated by Pegivirus C and involved in cilium movement. This specific gene exhibits a log2 fold change of -1.244 and an adjusted p-value of 0.03284. What molecular function is enabled by this gene? | microtubule motor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07356","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified as being downregulated by Pegivirus C and... | |
medium_hidden_intermediate_07358 | Zaire ebolavirus upregulates a gene that is involved in the positive regulation of cell migration. Evidence for this gene in a specific study reports a log2 fold change of 1.210 and an adjusted p-value of 0.03534. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07358","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that is involved in the positive regulation of cell migration. Evidence for this gene in... | |
medium_hidden_intermediate_07359 | Rhinovirus A infection leads to the downregulation of certain genes that participate in post-translational protein modification. In a study of cytotoxic T-lymphocytes (GSE106475), one such gene exhibited a log2 fold change of -1.383 and an adjusted p-value of 0.003142. Which protein is encoded by this specific gene? | CD109 antigen | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07359","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of certain genes that participate in post-translational protein modificat... | |
medium_hidden_intermediate_07360 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of certain genes involved in RNA metabolism. One such gene exhibits a log2 fold change of -1.029 and an adjusted p-value of 0.01939. Which protein is encoded by this specific gene? | Small ribosomal subunit protein eS28 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07360","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of certain... | |
medium_hidden_intermediate_07361 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both enable GTPase activator activity. One of these genes exhibits a log2 fold change of -1.933 and an adjusted p-value of 0.0171 in lung cells. Which disease is associated with genomic alterations in this specific gene? | post-traumatic stress disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07361","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both enable GTPase activator activi... | |
medium_hidden_intermediate_07362 | Vaccinia virus upregulates a gene that is associated with aneuploidy. Evidence for this gene in cervical adenocarcinoma cell lines (study GSE11238) reports a log2 fold change of 3.050 and an adjusted p-value of 2.241e-10. Which disease is connected to this gene through genomic alterations? | Meier-Gorlin syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07362","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that is associated with aneuploidy. Evidence for this gene in cervical adenocarcinoma cell... | |
medium_hidden_intermediate_07363 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in Post-translational protein phosphorylation. One of these genes shows a log2 fold change of 2.369 and an adjusted p-value of 0.01166 in a specific study. Which cell type is enriched for this specific gene? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07363","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in Post-translational protein phosphorylation. O... | |
medium_hidden_intermediate_07364 | JAG1 interacts with a specific E3 ubiquitin ligase that participates in Signaling by NOTCH2. Experimental evidence indicates that while both wild-type and mutant Jagged1 interact with this ligase (identified as Mind bomb), only the wild-type form shows enhanced ubiquitylation upon co-culture with cells expressing the N... | E3 ubiquitin-protein ligase MIB1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07364","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"JAG1 interacts with a specific E3 ubiquitin ligase that participates in Signaling by NOTCH2. Experimental evidence indicates... | |
medium_hidden_intermediate_07365 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with UBE2I. The expression data for this intermediate gene shows a log2 fold change of approximately -1.17 and an adjusted p-value of 0.012. Which protein is encoded by this gene? | Transcription factor SOX-6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07365","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_07366 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Circadian clock. Experimental data for this gene reports a log2 fold change of 1.920 and an adjusted p-value of 0.03495. Which protein is encoded by this gene? | Proteasome subunit beta type-5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07366","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Circadian clock. Expe... | |
medium_hidden_intermediate_07369 | Hepacivirus C upregulates a gene that is involved in platelet activation. Evidence for one such gene reports a log2 fold change of 1.246 and an adjusted p-value of 0.02394. Which protein is encoded by that gene? | Biogenesis of lysosome-related organelles complex 1 subunit 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07369","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in platelet activation. Evidence for one such gene reports a log2 fold cha... | |
medium_hidden_intermediate_07370 | Rhinovirus A upregulates a gene that participates in RNA Polymerase II Transcription. Evidence for this gene reports a log2 fold change of 1.025 and an adjusted p-value of 0.01164. Which protein is encoded by this gene? | Zinc finger protein 597 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07370","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A upregulates a gene that participates in RNA Polymerase II Transcription. Evidence for this gene reports a log2 ... | |
medium_hidden_intermediate_07371 | Identify the gene that serves as a marker for Exhausted CD8+ T cells and is involved in the immune response. This gene is characterized by its role in targeting the SET complex, a macromolecular complex of 270-420 kDa associated with the endoplasmic reticulum, during cell-mediated death. Which disease is associated wit... | asthma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07371","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Identify the gene that serves as a marker for Exhausted CD8+ T cells and is involved in the immune response. This gene is ch... | |
medium_hidden_intermediate_07374 | A gene is downregulated by Cardiovirus A and enriched in Regulatory T (Treg) cells. Evidence for this gene in cervical adenocarcinoma cell lines (study GSE122967) reports a log2 fold change of approximately -1.18 and an adjusted p-value of 0.0235. Which biological process is this gene involved in? | positive regulation of RNA splicing | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07374","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and enriched in Regulatory T (Treg) cells. Evidence for this gene in cervical adeno... | |
medium_hidden_intermediate_07375 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and involved in the negative regulation of lymphocyte migration. Evidence for this gene reports a log2 fold change of 4.442 and an adjusted p-value of 0.02822. Which protein is encoded by this gene? | Germinal center-associated signaling and motility protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07375","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and involved i... | |
medium_hidden_intermediate_07376 | YAP1 interacts with a gene that is enriched in eosinophils. One such gene exhibits a mean expression of 33.38 TPM, a z-score of 2.24, and a fold enrichment of 9.20 in immune cell RNA-seq data. Which gene interacts with this specific eosinophil-enriched gene? | ITCH | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07376","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"YAP1 interacts with a gene that is enriched in eosinophils. One such gene exhibits a mean expression of 33.38 TPM, a z-score... | |
medium_hidden_intermediate_07377 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene that participates in the epigenetic regulation of gene expression. This gene exhibited a log2 fold change of -1.484 and an adjusted p-value of 0.02988. Which protein is encoded by this gene? | KAT8 regulatory NSL complex subunit 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07377","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_07378 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus and its product interacts with RAC1. Experimental data for this gene in a cardiomyocyte cell line shows a log2 fold change of approximately 1.129 and an adjusted p-value of 0.01076. Which protein i... | Mitogen-activated protein kinase kinase kinase kinase 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07378","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus a... | |
medium_hidden_intermediate_07379 | Human alphaherpesvirus 1 upregulates a gene that participates in the Cell Cycle. In a study of monocytic leukemia cell lines (GSE114966), one such upregulated gene exhibited a log2 fold change of 2.422 and an adjusted p-value of 0.002971. Which biological process is this specific gene involved in? | DNA replication | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07379","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in the Cell Cycle. In a study of monocytic leukemia cell lines... | |
medium_hidden_intermediate_07380 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to PTPRS via a 'binds' relationship. One of these genes is associated with experimental data showing a log2 fold change of 1.284 and an adjusted p-value of 0.0319. Which protein is encoded by... | Liprin-beta-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07380","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_07381 | Zika virus downregulates a gene that is involved in the regulation of DNA-templated transcription. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.75 and an adjusted p-value of 0.0039. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07381","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the regulation of DNA-templated transcription. In a study of glioma stem... | |
medium_hidden_intermediate_07382 | GNA15 interacts with a specific protein that serves as a biomarker for schizophrenia. Evidence indicates that down-regulation of the histamine H1 receptor in the frontal cortex may be involved in the pathophysiology of schizophrenia. Which disease is associated with this specific protein through genomic alterations? | arteriosclerosis disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07382","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"GNA15 interacts with a specific protein that serves as a biomarker for schizophrenia. Evidence indicates that down-regulatio... | |
medium_hidden_intermediate_07384 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Acyl chain remodelling of PE. Evidence for one such gene reports a log2 fold change of approximately 1.004 and an adjusted p-value of 2.972e-06. Which biological process is this gene involved in? | lysosomal protein catabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07384","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Acyl chain remodelling of PE. ... | |
medium_hidden_intermediate_07385 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with TP53. One such gene exhibits a log2 fold change of approximately 1.032 and an adjusted p-value of 0.005077. Which protein is encoded by this specific gene? | Cathepsin B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07385","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with TP... | |
medium_hidden_intermediate_07387 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in MHC class II antigen presentation. Evidence for one such gene reports a log2 fold change of 1.424 and an adjusted p-value of 0.0424. Which protein is encoded by that gene? | Cathepsin F | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07387","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in MHC class II antigen presentat... | |
medium_hidden_intermediate_07388 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene involved in RNA splicing. This specific gene exhibited a log2 fold change of approximately 1.31 and an adjusted p-value of approximately 1.89e-06. Which protein is encoded by this gene? | Programmed cell death protein 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07388","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene involve... | |
medium_hidden_intermediate_07391 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of cell migration. Evidence for this gene reports a log2 fold change of approximately 1.23 and an adjusted p-value of approximately 0.0069. Which protein is encoded by this gene? | Adhesion G protein-coupled receptor G3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07391","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of cell mig... | |
medium_hidden_intermediate_07392 | Two genes are linked to Vaccinia virus via upregulation and to psoriasis as biomarkers. One of these genes exhibits a log2 fold change of approximately 3.285 and an adjusted p-value of 0.0002373 in cervical adenocarcinoma cell lines. Which protein is encoded by this specific gene? | G-protein coupled receptor 15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07392","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Vaccinia virus via upregulation and to psoriasis as biomarkers. One of these genes exhibits a log2 f... | |
medium_hidden_intermediate_07394 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with LIN28A. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of approximately -1.776 and an adjusted p-value of 0.01276. Which protein is encoded by this ge... | Pentatricopeptide repeat-containing protein 1, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07394","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with LIN28A. Experimental data for this int... | |
medium_hidden_intermediate_07395 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and its protein product is located in the cytoplasmic stress granule. One such gene exhibits a log2 fold change of approximately 1.88 and an adjusted p-value of 0.0325. Which protein is encoded by this gene? | KH domain-containing RNA-binding protein QKI | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07395","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and its protein... | |
medium_hidden_intermediate_07396 | Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus to lung adenocarcinoma via a downregulation relationship followed by a biomarker association. One of these genes is associated with a log2 fold change of -2.336 and an adjusted p-value of 0.02097 in a specific study. Which prot... | EGF-like repeat and discoidin I-like domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07396","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus to lung adenocarcinoma via a do... | |
medium_hidden_intermediate_07398 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with astrocytoma (excluding glioblastoma). One of these genes has a reported log2 fold change of 2.592 and an adjusted p-value of 0.005949. Which protein is encoded by this specific gene? | Embigin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07398","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with astrocytoma (excl... | |
medium_hidden_intermediate_07401 | Human alphaherpesvirus 1 downregulates a gene that is located in the mitochondrion. In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibited a log2 fold change of approximately -1.084 and an adjusted p-value of 0.001163. Which protein does this specific gene product interact with? | SNCA | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07401","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 downregulates a gene that is located in the mitochondrion. In a study of monocytic leukemia cell li... | |
medium_hidden_intermediate_07402 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate a specific gene that is also associated with carcinoma. This gene exhibited a log2 fold change of 1.609 and an adjusted p-value of 9.474e-09. Which biological process is this gene involved in? | negative regulation of DNA-templated transcription | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07402","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate... | |
medium_hidden_intermediate_07403 | A gene serves as a marker for mitotic arrest phase fetal germ cells and is enriched in naive thymus-derived CD4-positive, alpha-beta T cells. Evidence for one such gene reports a mean expression of 2.94 TPM, a z-score of 2.36, and a fold enrichment of 5.79. Which disease is associated with this gene as a biomarker? | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07403","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for mitotic arrest phase fetal germ cells and is enriched in naive thymus-derived CD4-positive, al... | |
medium_hidden_intermediate_07404 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable protein serine/threonine kinase activity. One of these genes exhibits a log2 fold change of approximately 1.40 and an adjusted p-value of 0.00602 in a specific study. Which protein does this specific gene interact with? | CUL3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07404","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable protein serine/threonine ... | |
medium_hidden_intermediate_07405 | Human immunodeficiency virus 1 upregulates a gene that is located in the nucleolus. Evidence for this gene reports a log2 fold change of approximately 1.053 and an adjusted p-value of 0.00827. Which protein is encoded by this gene? | CDKN2A-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07405","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located in the nucleolus. Evidence for this gene reports a log2 fo... | |
medium_hidden_intermediate_07407 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the defense response to bacterium. One of these genes exhibits a log2 fold change of approximately -2.50 and an adjusted p-value of 0.0475 in corneal epithelium. What molecular function is enabled by this specific g... | wide pore channel activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07407","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the defense respons... | |
medium_hidden_intermediate_07408 | Two genes are structurally linked to both Pegivirus C (via downregulation) and Leishmania infection (via participation). One of these genes exhibits a log2 fold change of approximately -1.03 and an adjusted p-value of approximately 0.0015 in peripheral blood mononuclear cells from study GSE131504. Which protein is enco... | Actin-related protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07408","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to both Pegivirus C (via downregulation) and Leishmania infection (via participation). One... | |
medium_hidden_intermediate_07409 | Pegivirus C is reported to downregulate a gene that is involved in the regulation of G protein-coupled receptor signaling pathway. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.19 and an adjusted p-value of 0.0135. Which protein is encoded b... | Regulator of G-protein signaling 12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07409","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the regulation of G protein-coupled receptor signaling pa... | |
medium_hidden_intermediate_07410 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with RPS6. Evidence for this gene reports a log2 fold change of 1.197 and an adjusted p-value of 0.03381. Which molecular function is enabled by this gene? | RNA binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07410","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with RPS6. Evidence for this gene re... | |
medium_hidden_intermediate_07413 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in the RHO GTPase cycle. One of these genes shows a log2 fold change of 1.149 and an adjusted p-value of 0.001832 in a specific study. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07413","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in the RHO GTPase cycle. One of these genes show... | |
medium_hidden_intermediate_07414 | Two genes are structurally positioned between Severe acute respiratory syndrome-related coronavirus and HSP90AA1, linked by upregulation from the virus and interaction with the heat shock protein. One of these genes exhibits a log2 fold change of 2.319 and an adjusted p-value of 0.003158 in a specific study. Which dise... | cervical cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07414","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally positioned between Severe acute respiratory syndrome-related coronavirus and HSP90AA1, linked by ... | |
medium_hidden_intermediate_07415 | In a study of non-small cell lung adenocarcinoma, a gene upregulated by Influenza A virus and involved in post-translational protein modification showed a log2 fold change of 1.371 and an adjusted p-value of 0.0002254. Which protein is encoded by this gene? | SPARC-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07415","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma, a gene upregulated by Influenza A virus and involved in post-translational... | |
medium_hidden_intermediate_07419 | A gene serves as a marker for Paneth cells and is enriched in neutrophils. Evidence for this gene includes a mean expression of 139.03 TPM, a z-score of 1.90, and a fold enrichment of 10.90. Which protein does this gene product interact with? | KEAP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07419","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Paneth cells and is enriched in neutrophils. Evidence for this gene includes a mean expression... | |
medium_hidden_intermediate_07421 | Pegivirus C is reported to downregulate a specific gene, the product of which enables ubiquitin protein ligase binding. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -1.579 and an adjusted p-value of 0.00287. Which protein is encoded by this gene? | DnaJ homolog subfamily A member 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07421","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, the product of which enables ubiquitin protein ligase binding. In a... | |
medium_hidden_intermediate_07422 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to GDNF. Evidence for this gene reports a log2 fold change of 1.012 and an adjusted p-value of 0.0009571. Which disease is associated with this gene as a biomarker? | Hirschsprung disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07422","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to GDNF. Evidence for this gene rep... | |
medium_hidden_intermediate_07423 | In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in turn encodes a protein that binds to POLR2H. The expression data for this gene shows a log2 fold change of approximately -1.55 and an adjusted p-value of 0.015. Which protein is encoded by this gen... | Protein Red | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07423","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in t... | |
medium_hidden_intermediate_07424 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that is involved in the cell surface receptor signaling pathway. This specific gene exhibits a log2 fold change of 1.717 and an adjusted p-value of 0.03045. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07424","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that is involved in the cell ... | |
medium_hidden_intermediate_07426 | A gene is upregulated by Measles morbillivirus and enriched in naive B cells. Experimental data for this gene reports a log2 fold change of approximately 3.03 and an adjusted p-value of approximately 0.005. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07426","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and enriched in naive B cells. Experimental data for this gene reports a log2... | |
medium_hidden_intermediate_07427 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables magnesium ion binding. One such gene exhibits a log2 fold change of 1.020 and an adjusted p-value of 0.000213. Which cellular component is this specific gene located in? | peroxisome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07427","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables magnesium ion binding.... | |
medium_hidden_intermediate_07429 | Zika virus downregulates a gene that participates in the mitotic cell cycle. Evidence for this gene shows a log2 fold change of approximately -1.84 and an adjusted p-value of approximately 0.019. In which cell type is this gene enriched? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07429","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the mitotic cell cycle. Evidence for this gene shows a log2 fold change... | |
medium_hidden_intermediate_07430 | Pegivirus C is associated with the downregulation of multiple genes, which in turn exhibit genomic alterations linked to head and neck squamous cell carcinoma. One such gene shows a log2 fold change of approximately -1.059 and an adjusted p-value of 0.002406 in peripheral blood mononuclear cells (study GSE131504). Whic... | Reduced folate transporter | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07430","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is associated with the downregulation of multiple genes, which in turn exhibit genomic alterations linked to hea... | |
medium_hidden_intermediate_07431 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Signaling by NOTCH1. One of these genes exhibits a log2 fold change of approximately -1.35 and an adjusted p-value of approximately 0.048 in a specific study. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07431","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Signaling by NOTCH1.... |
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