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medium_hidden_intermediate_07433 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with MIS12. One of these genes has a reported log2 fold change of 1.402 and an adjusted p-value of 0.001856. Which protein is encoded by this specific gene? | Kinesin light chain 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07433","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with MIS12. One of these gen... | |
medium_hidden_intermediate_07435 | In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its product interacts with MARCH5. Transcriptomic data for this gene in lung tissue shows a log2 fold change of approximately 1.128 and an adjusted p-value of 0.02826. Which protein is encoded by this g... | Serine/threonine-protein kinase/endoribonuclease IRE1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07435","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its pr... | |
medium_hidden_intermediate_07439 | Hepacivirus C is reported to downregulate a gene that serves as a biomarker for adult glioblastoma. In a specific study (GSE132606) involving hepatocytes, this gene exhibited a log2 fold change of approximately -1.068 and an adjusted p-value of 5.178e-07. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07439","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that serves as a biomarker for adult glioblastoma. In a specific study (GSE... | |
medium_hidden_intermediate_07440 | Zika virus downregulates a specific gene, the product of which interacts with VAPB. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -3.622 and an adjusted p-value of 0.001455. Which protein is encoded by this gene? | WD repeat-containing protein 44 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07440","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, the product of which interacts with VAPB. In a study of glioma stem cells (GSE1149... | |
medium_hidden_intermediate_07441 | A gene is upregulated by Measles morbillivirus and participates in the process where SUMO E3 ligases SUMOylate target proteins. Experimental data for this gene reports a log2 fold change of 1.145 and an adjusted p-value of 0.02839. Which disease is associated with this gene as a biomarker? | liver cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07441","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and participates in the process where SUMO E3 ligases SUMOylate target protei... | |
medium_hidden_intermediate_07443 | Vaccinia virus infection leads to the upregulation of certain genes that participate in biological oxidations. One such gene exhibits a log2 fold change of 2.217 and an adjusted p-value of 3.184e-09 in cervical adenocarcinoma cell lines. Which disease is associated with genomic alterations in this specific gene? | oropharynx cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07443","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus infection leads to the upregulation of certain genes that participate in biological oxidations. One such gene... | |
medium_hidden_intermediate_07444 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the regulation of cell population proliferation. Experimental data for this gene reports a log2 fold change of 2.721 and an adjusted p-value of 0.007199. Which protein is encoded by this gene? | Immediate early response gene 5 protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07444","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the regulation of cell populati... | |
medium_hidden_intermediate_07447 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Disorders of transmembrane transporters. Experimental data for this gene in choroid plexus epithelium (study GSE157852) shows a log2 fold change of approximately -3.15 and an adjusted p-value of 0.0001498. Which disease... | anemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07447","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Disorders of transmembr... | |
medium_hidden_intermediate_07448 | Hepacivirus C is reported to downregulate a gene that enables thyroid hormone binding. In a study of peripheral blood mononuclear cells (GSE119117), one such gene showed a log2 fold change of approximately -1.215 and an adjusted p-value of 0.004362. Which protein is encoded by this specific gene? | Thyroid hormone receptor alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07448","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that enables thyroid hormone binding. In a study of peripheral blood mononu... | |
medium_hidden_intermediate_07449 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to upregulate a specific gene, which is implicated in infectious disease. This gene exhibited a log2 fold change of 1.022 and an adjusted p-value of 0.0337. Which protein does this upregulated gene interact with? | PHB1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07449","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_07450 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that participate in the RAF/MAP kinase cascade. One such gene exhibited a log2 fold change of 1.383 and an adjusted p-value of 0.04008. Which protein is encoded by this specific gene? | Alpha/beta hydrolase domain-containing protein 17C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07450","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that partici... | |
medium_hidden_intermediate_07451 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn participates in RNA metabolism. Evidence for this gene shows a log2 fold change of -1.118 and an adjusted p-value of 0.02758. Which biological process is this gene involved... | RNA methylation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07451","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_07453 | Human immunodeficiency virus 1 upregulates a gene that subsequently binds to UBE2M. Experimental data for this gene reports a log2 fold change of 1.126 and an adjusted p-value of 2.014e-05. Which protein is encoded by this gene? | Protein fem-1 homolog A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07453","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that subsequently binds to UBE2M. Experimental data for this gene reports ... | |
medium_hidden_intermediate_07454 | In a study of choroid plexus epithelium (GSE157852), a gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the function of Glucagon-type ligand receptors. This specific gene exhibits a log2 fold change of -1.043 and an adjusted p-value of 0.001855. Which cellular component... | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07454","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), a gene is downregulated by Severe acute respiratory syndrome-related co... | |
medium_hidden_intermediate_07456 | Two genes are upregulated by Vaccinia virus and participate in Visual phototransduction. One of these genes exhibits a log2 fold change of 2.368 and an adjusted p-value of 1.233e-09 in a specific study. Which cell type is enriched for this specific gene? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07456","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in Visual phototransduction. One of these genes exhibits a log2 ... | |
medium_hidden_intermediate_07457 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is involved in cell-cell signaling. This specific gene exhibits a log2 fold change of approximately 3.71 and an adjusted p-value of 0.0118. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07457","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is involved in cell-cell signa... | |
medium_hidden_intermediate_07458 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and bind to SNRPD1. One of these genes exhibits a log2 fold change of 1.444 and an adjusted p-value of 0.002837 in a specific study. Which protein is encoded by this gene? | RNA-binding region-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07458","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and bind to SNRPD1. One of these genes ex... | |
medium_hidden_intermediate_07459 | Zika virus downregulates a specific gene that interacts with HNRNPU. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.859 and an adjusted p-value of 0.01077. Which biological process is this gene involved in? | regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07459","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that interacts with HNRNPU. In a study of glioma stem cells (GSE114907), this gene ... | |
medium_hidden_intermediate_07460 | Severe acute respiratory syndrome-related coronavirus is linked to a gene that is associated with nervous system disorder. Evidence for this gene reports a log2 fold change of -1.344 and an adjusted p-value of 0.007978. Which protein is encoded by this gene? | Class E basic helix-loop-helix protein 23 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07460","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is linked to a gene that is associated with nervous system disorder. E... | |
medium_hidden_intermediate_07461 | IGF2 binds to a specific protein, which in turn participates in RNA Polymerase II transcription. Experimental evidence regarding this protein indicates that substituting specific amino acids with glycine significantly impacts its function: a single change to a nonconserved glycine causes a notable decrease in binding, ... | autism spectrum disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07461","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"IGF2 binds to a specific protein, which in turn participates in RNA Polymerase II transcription. Experimental evidence regar... | |
medium_hidden_intermediate_07462 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes that are enriched in natural killer cells. One such gene exhibits a log2 fold change of -1.607 and an adjusted p-value of 5.421e-05. Which protein is encoded by this specific gene? | 2-phosphoxylose phosphatase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07462","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes that ... | |
medium_hidden_intermediate_07463 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene, which is involved in protein autophosphorylation. This gene exhibited a log2 fold change of -1.961 and an adjusted p-value of 0.01665. Which protein is encoded by this gene? | Mitogen-activated protein kinase kinase kinase 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07463","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_07465 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is downregulated by Vaccinia virus and participates in the metabolism of proteins. This specific gene exhibits a log2 fold change of approximately -1.56 and an adjusted p-value of approximately 0.0148. Which protein does this gene bind to? | TTF1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07465","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is downregulated by Vaccinia virus and participates in t... | |
medium_hidden_intermediate_07468 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and is involved in protein folding. Evidence for this gene reports a log2 fold change of 1.362 and an adjusted p-value of 0.001603. Which protein is encoded by this gene? | Endoplasmic reticulum resident protein 44 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07468","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and is involve... | |
medium_hidden_intermediate_07470 | A gene is downregulated by Human immunodeficiency virus 1 and enriched in memory B cells. Evidence for this gene in macrophages reports a log2 fold change of approximately -1.07 and an adjusted p-value of 0.0269. Which disease is associated with this gene? | hydatidiform mole, recurrent, 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07470","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human immunodeficiency virus 1 and enriched in memory B cells. Evidence for this gene in macropha... | |
medium_hidden_intermediate_07471 | In a study of rhabdomyosarcoma cells (GSE103308), a gene is identified as being upregulated by Enterovirus A and serving as a biomarker for breast carcinoma. This specific gene exhibits a log2 fold change of approximately 1.26 and an adjusted p-value of 0.0013. Which protein is encoded by this gene? | BRCA2-interacting transcriptional repressor EMSY | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07471","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), a gene is identified as being upregulated by Enterovirus A and serving as ... | |
medium_hidden_intermediate_07472 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and is involved in signal transduction. This gene exhibits a log2 fold change of 2.172 and an adjusted p-value of 0.02612. Which cellular component is this gene located in? | actin cytoskeleton | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07472","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and is involved in signal transdu... | |
medium_hidden_intermediate_07474 | A gene is downregulated by Primate bocaparvovirus 1 and its protein product is located in the extracellular space. Experimental evidence for this gene reports a log2 fold change of -4.387 and an adjusted p-value of 0.0004332. Which gene interacts with the protein encoded by this gene? | NDN | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07474","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and its protein product is located in the extracellular space. Experimen... | |
medium_hidden_intermediate_07479 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is identified as being downregulated by Vaccinia virus and serving as a biomarker for ischemic stroke. This specific gene exhibits a log2 fold change of -2.104 and an adjusted p-value of 0.004015. Which protein is encoded by this gene? | Protein NDRG2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07479","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is identified as being downregulated by Vaccinia virus a... | |
medium_hidden_intermediate_07480 | In a study of Influenza A virus infection, a specific gene is downregulated by the virus and participates in signal transduction. Experimental data for this gene reports a log2 fold change of -1.092 and an adjusted p-value of 0.01208. Which protein is encoded by this gene? | Switch-associated protein 70 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07480","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is downregulated by the virus and participates in signal transduc... | |
medium_hidden_intermediate_07481 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the RAC2 GTPase cycle. One of these genes shows a log2 fold change of approximately 1.48 and an adjusted p-value of approximately 0.035 in a specific study. Which biological process is this specific gene involved in? | regulation of cell migration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07481","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the RAC2 GTPase cycle.... | |
medium_hidden_intermediate_07482 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both bind to POLR2J. One of these genes exhibits a log2 fold change of approximately 1.14 and an adjusted p-value of approximately 8.6e-05 in a specific study. Which protein is encoded by this gene? | Poly(A) polymerase alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07482","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both bind to POLR2J. One of these gen... | |
medium_hidden_intermediate_07484 | Two genes are structurally linked to Enterovirus A via downregulation and to Gastrulation via participation. One of these genes exhibits a log2 fold change of -1.681 and an adjusted p-value of 0.02355 in rhabdomyosarcoma cells. Which disease is associated with this specific gene as a biomarker? | benign neoplasm of sweat gland | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07484","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via downregulation and to Gastrulation via participation. One of these ge... | |
medium_hidden_intermediate_07485 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of certain genes whose products are located in the lysosomal membrane. One such gene exhibits a log2 fold change of approximately -1.16 and an adjusted p-value of 0.01011. Which protein is encoded by this specif... | Regulator of MON1-CCZ1 complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07485","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of certain gene... | |
medium_hidden_intermediate_07486 | Two genes are known to be upregulated by Measles morbillivirus and to interact with CCNF. One of these genes was reported in a study (GSE131840) with a log2 fold change of approximately 1.148 and an adjusted p-value of 0.04801. Which disease is associated with this specific gene? | purpura | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07486","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are known to be upregulated by Measles morbillivirus and to interact with CCNF. One of these genes was reported in... | |
medium_hidden_intermediate_07488 | In a study of glioma stem cells (GSE114907), Zika virus downregulates a specific gene that subsequently interacts with PPP1CC. This gene exhibits a log2 fold change of approximately -1.54 and an adjusted p-value of 0.0203. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07488","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus downregulates a specific gene that subsequently interacts with PPP1C... | |
medium_hidden_intermediate_07489 | RAB27A interacts with a protein that is involved in exocytosis. Evidence indicates that this protein, identified as Slp4-a (synaptotagmin-like protein 4-a) or granuphilin-a, is specifically localized on dense-core vesicles in PC12 cells and negatively controls dense-core vesicle exocytosis through specific interaction ... | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07489","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"RAB27A interacts with a protein that is involved in exocytosis. Evidence indicates that this protein, identified as Slp4-a (... | |
medium_hidden_intermediate_07490 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of a specific gene, which is subsequently associated with hyperplasia. This gene exhibits a log2 fold change of -1.679 and an adjusted p-value of 0.0032. Which protein is encoded by this gene? | Ras association domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07490","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_07491 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a gene that subsequently interacts with SFXN1. One such gene exhibits a log2 fold change of approximately -1.092 and an adjusted p-value of 0.0007951. Which protein is encoded by this specific gene? | Adenylate kinase 2, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07491","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a gene that subsequently interacts with ... | |
medium_hidden_intermediate_07493 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with TRAF6. One of these genes exhibits a log2 fold change of -4.530 and an adjusted p-value of 0.03442 in bronchial epithelial cells. Which cellular component is the location of this specific gene? | perinuclear region of cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07493","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with TRAF6. One of these g... | |
medium_hidden_intermediate_07497 | Two genes are structurally linked in a pathway where Human immunodeficiency virus 1 upregulates the gene, and the gene participates in Leishmania parasite growth and survival. One of these genes has an associated expression profile in macrophages (from study GSE108897) showing a log2 fold change of approximately 2.10 a... | obesity disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07497","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked in a pathway where Human immunodeficiency virus 1 upregulates the gene, and the gene parti... | |
medium_hidden_intermediate_07499 | Pegivirus C is reported to downregulate a gene that is located in the mitochondrial matrix. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.271 and an adjusted p-value of 0.0218. Which biological process is this specific gene involved in? | acetyl-CoA biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07499","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the mitochondrial matrix. In a study of peripheral blood m... | |
medium_hidden_intermediate_07500 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in heart development. Evidence for one such gene reports a log2 fold change of -2.152 and an adjusted p-value of 0.0423. Which protein is encoded by that gene? | POU domain, class 6, transcription factor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07500","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in heart development. Evidence f... | |
medium_hidden_intermediate_07501 | Measles morbillivirus downregulates a specific gene that is enriched in naive CD4+ T cells. Experimental data for this gene reports a log2 fold change of -1.956 and an adjusted p-value of 2.503e-06. Which biological process is this gene involved in? | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07501","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a specific gene that is enriched in naive CD4+ T cells. Experimental data for this gene ... | |
medium_hidden_intermediate_07502 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the regulation of cholesterol biosynthesis by SREBP (SREBF). Evidence for this gene reports a log2 fold change of 1.041 and an adjusted p-value of 0.04071. Which cellular component is this gene located in? | peroxisome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07502","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the regulation of cholest... | |
medium_hidden_intermediate_07504 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Glycosaminoglycan metabolism. One of these genes exhibits a log2 fold change of -1.025 and an adjusted p-value of 0.03944 in a specific study. Which disease is associated with this gene as a biomarker? | Ehlers-Danlos syndrome, spondylodysplastic type, 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07504","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Glycosaminoglycan me... | |
medium_hidden_intermediate_07505 | Human betaherpesvirus 5 is reported to downregulate a specific gene, which in turn participates in post-translational protein modification. Experimental data from foreskin fibroblast cell lines (study GSE111036) indicate that this gene exhibits a log2 fold change of approximately -1.374 and an adjusted p-value of 0.045... | axon regeneration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07505","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a specific gene, which in turn participates in post-translational protei... | |
medium_hidden_intermediate_07507 | Two genes are structurally linked from Hepacivirus C to neuroblastoma via an upregulation relationship followed by a biomarker association. One of these genes is reported in a study (GSE132606) with a log2 fold change of approximately 1.369 and an adjusted p-value of 0.0003991. Which protein is encoded by the gene matc... | Far upstream element-binding protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07507","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Hepacivirus C to neuroblastoma via an upregulation relationship followed by a biomark... | |
medium_hidden_intermediate_07508 | A gene is connected to CDK2 via an 'interacts with' relationship and to 'protein binding' via an 'enables' relationship. Contextual evidence states: 'Furthermore, mutation of the conserved Speedy/Ringo box, known to mediate interaction with CDK2, abrogates the ability of the protein encoded by this gene to inhibit apop... | Speedy protein A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07508","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is connected to CDK2 via an 'interacts with' relationship and to 'protein binding' via an 'enables' relationship. Con... | |
medium_hidden_intermediate_07509 | Pegivirus C is reported to downregulate multiple genes that are located in the Golgi apparatus. One such gene exhibits a log2 fold change of -3.069 and an adjusted p-value of 2.056e-05 in peripheral blood mononuclear cells (study GSE131504). Which protein is encoded by this specific gene? | Protein-associating with the carboxyl-terminal domain of ezrin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07509","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate multiple genes that are located in the Golgi apparatus. One such gene exhibits a log... | |
medium_hidden_intermediate_07511 | Zika virus infection leads to the upregulation of certain genes that participate in metabolism. One such gene exhibits a log2 fold change of 1.698 and an adjusted p-value of 0.005432 in glioblastoma multiforme cancer stem cells. Which protein is encoded by this specific gene? | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07511","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the upregulation of certain genes that participate in metabolism. One such gene exhibits a log... | |
medium_hidden_intermediate_07512 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is downregulated by the virus and is involved in the G1/S transition of the mitotic cell cycle. This gene exhibits a log2 fold change of approximately -1.73 and an adjusted p-value of approximately ... | G1/S-specific cyclin-D2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07512","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is... | |
medium_hidden_intermediate_07514 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with PTEN. This gene exhibited a log2 fold change of approximately -1.10 and an adjusted p-value of 0.0018. Which protein is encoded by this gene? | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07514","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_07515 | In a study of Influenza A virus infection, a specific gene is downregulated by the virus and participates in gene expression (transcription). Evidence for this gene reports a log2 fold change of -1.547 and an adjusted p-value of 0.001289. Which protein is encoded by this gene? | ATP-binding cassette sub-family A member 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07515","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is downregulated by the virus and participates in gene expression... | |
medium_hidden_intermediate_07517 | Zika virus infection upregulates certain genes that are involved in the ERAD pathway. One such gene exhibits a log2 fold change of approximately 1.25 and an adjusted p-value of 0.0229 in glioblastoma multiforme cancer stem cells. Which protein is encoded by this specific gene? | ER degradation-enhancing alpha-mannosidase-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07517","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection upregulates certain genes that are involved in the ERAD pathway. One such gene exhibits a log2 fold cha... | |
medium_hidden_intermediate_07518 | Zika virus downregulates a gene that binds to DMTN. Evidence for one such gene reports a log2 fold change of -1.539 and an adjusted p-value of 0.007093. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07518","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that binds to DMTN. Evidence for one such gene reports a log2 fold change of -1.539 and an a... | |
medium_hidden_intermediate_07521 | Human immunodeficiency virus 1 upregulates a gene that interacts with DYRK1B. Evidence for one such gene reports a log2 fold change of 1.520 and an adjusted p-value of 4.112e-05. Which disease is associated with that gene? | pterin-4 alpha-carbinolamine dehydratase 1 deficiency | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07521","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that interacts with DYRK1B. Evidence for one such gene reports a log2 fold... | |
medium_hidden_intermediate_07522 | A gene is upregulated by Primate bocaparvovirus 1 and is enriched in Naive CD4+ T cells. Evidence for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of approximately 1.86 and an adjusted p-value of approximately 0.036. Which protein is encoded by this gene? | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07522","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is enriched in Naive CD4+ T cells. Evidence for this gene in a non-Hod... | |
medium_hidden_intermediate_07523 | Human alphaherpesvirus 1 upregulates a gene that participates in the mitotic cell cycle. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of 2.992 and an adjusted p-value of 0.001958. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07523","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in the mitotic cell cycle. Evidence for this gene in a monocyt... | |
medium_hidden_intermediate_07526 | Two genes are upregulated by Human alphaherpesvirus 1 and interact with CCNF. One of these genes was reported in a study (GSE114966) on a monocytic leukemia cell line with a log2 fold change of approximately 1.022 and an adjusted p-value of 0.01348. Which disease is associated with this specific gene as a biomarker? | heart failure | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07526","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human alphaherpesvirus 1 and interact with CCNF. One of these genes was reported in a study (GS... | |
medium_hidden_intermediate_07528 | Human betaherpesvirus 5 is reported to upregulate a specific gene, which is in turn associated with carcinoma. Experimental data for this gene in foreskin fibroblast cell lines (study GSE132081) indicate a log2 fold change of approximately 1.33 and an adjusted p-value of 0.0002767. Which disease is linked to this gene ... | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07528","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a specific gene, which is in turn associated with carcinoma. Experimental ... | |
medium_hidden_intermediate_07529 | Two genes are expressed in endothelial cells and encode proteins with G protein-coupled receptor activity. One of these genes is described as an orphan GPCR that plays a central role in development by suppressing Hedgehog signaling. Which disease is associated with genomic alterations in this specific gene? | pituitary stalk interruption syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07529","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are expressed in endothelial cells and encode proteins with G protein-coupled receptor activity. One of these gene... | |
medium_hidden_intermediate_07530 | In a study of neural stem cells infected with Zika virus (GSE129180), a specific gene is upregulated and enables calcium ion binding. This gene exhibits a log2 fold change of 1.332 and an adjusted p-value of 0.02951. Which disease is associated with this gene? | congestive heart failure | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07530","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of neural stem cells infected with Zika virus (GSE129180), a specific gene is upregulated and enables calcium ion... | |
medium_hidden_intermediate_07531 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene, which in turn participates in neutrophil degranulation. This gene exhibited a log2 fold change of approximately -1.345 and an adjusted p-value of 0.01456. Which protein is encoded by this gen... | Phospholipid-transporting ATPase IF | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07531","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_07532 | Two genes are each upregulated by Influenza A virus and enriched in intermediate monocytes. One of these genes has a reported log2 fold change of 1.208 and an adjusted p-value of 0.0002131 in non-small cell lung adenocarcinoma cell lines. Which protein does this specific gene interact with? | CANX | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07532","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Influenza A virus and enriched in intermediate monocytes. One of these genes has a reporte... | |
medium_hidden_intermediate_07534 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is upregulated by the virus and is involved in virion assembly. This gene exhibits a log2 fold change of approximately 1.32 and an adjusted p-value of approximately 0.027. Which protein is encoded b... | USP6 N-terminal-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07534","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is... | |
medium_hidden_intermediate_07537 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in spermatogenesis. Experimental data for this gene reports a log2 fold change of 5.652 and an adjusted p-value of 0.01792. Which molecular function is enabled by this gene? | poly(A)-specific ribonuclease activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07537","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in spermatogenesis. Experimen... | |
medium_hidden_intermediate_07539 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene located in the cytosol was found to be upregulated. This gene exhibited a log2 fold change of 1.237 and an adjusted p-value of 2.985e-05. Which disease is associated with this gene? | nephrotic syndrome, type 20 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07539","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene located in the cytos... | |
medium_hidden_intermediate_07540 | Cardiovirus A downregulates a specific gene, which in turn interacts with RUFY1. Experimental data for this intermediate gene reports a log2 fold change of -1.183 and an adjusted p-value of 0.0198. Which cell type is this intermediate gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07540","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a specific gene, which in turn interacts with RUFY1. Experimental data for this intermediate gen... | |
medium_hidden_intermediate_07541 | Two genes are structurally linked from Human immunodeficiency virus 1 via a downregulation relationship and onward to preeclampsia via an association relationship. One of these genes is reported in a study (GSE108897) on macrophages with a log2 fold change of approximately -2.89 and an adjusted p-value of 0.0154. Which... | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07541","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Human immunodeficiency virus 1 via a downregulation relationship and onward to preecl... | |
medium_hidden_intermediate_07542 | A gene serves as a marker for monocytes and is enriched in basophils. Expression data for this gene indicates a mean expression of 214.66 TPM, a z-score of 1.91, and a fold enrichment of 2.55. Which protein does this gene product bind to? | RABGGTB | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07542","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for monocytes and is enriched in basophils. Expression data for this gene indicates a mean express... | |
medium_hidden_intermediate_07544 | A gene is linked to NCOR2 via a binding interaction and is involved in Gene expression (Transcription). Experimental evidence indicates that in electrophoretic mobility shift assays, wild-type thyroid hormone receptor beta interacts with N-CoR in the absence of ligand, and T3 induces the dissociation of the thyroid hor... | Thyroid hormone receptor beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07544","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is linked to NCOR2 via a binding interaction and is involved in Gene expression (Transcription). Experimental evidenc... | |
medium_hidden_intermediate_07546 | In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and enriched in non-classical monocytes. One of these genes exhibits a log2 fold change of approximately 1.14 and an adjusted p-value of 0.0487. Which protein is encoded by this specific gene? | Ubiquitin-like-conjugating enzyme ATG3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07546","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and enriched in no... | |
medium_hidden_intermediate_07547 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the processing of SMDT1. One of these genes was reported in a study of bronchial epithelial cells (GSE150819) with a log2 fold change of 1.045 and an adjusted p-value of 0.03233. Which gene interacts with the gene iden... | SOCS6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07547","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the processing of SMDT... | |
medium_hidden_intermediate_07549 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and enables calcium ion sensor activity. This gene exhibits a log2 fold change of approximately 1.105 and an adjusted p-value of 8.404e-06. Which protein is encoded by this gene? | Calcium uptake protein 2, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07549","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and e... | |
medium_hidden_intermediate_07551 | Two genes are structurally linked to CSK via an interaction and to focal adhesion via localization. One of these genes is associated with a mutant that lost its ability to bind C-terminal Src kinase (Csk), a protein previously shown to interact with a scaffold protein by Far Western analysis. Which disease is connected... | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07551","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to CSK via an interaction and to focal adhesion via localization. One of these genes is as... | |
medium_hidden_intermediate_07552 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participates in the process where PPARA activates gene expression. Evidence for this gene reports a log2 fold change of 1.258 and an adjusted p-value of 0.001533. Which molecular function is enabled by this... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07552","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participat... | |
medium_hidden_intermediate_07553 | Pegivirus C is reported to downregulate a gene that is involved in the ceramide biosynthetic process. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.34 and an adjusted p-value of approximately 0.012. Which protein is encoded by this specific ... | Phosphatidylcholine:ceramide cholinephosphotransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07553","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the ceramide biosynthetic process. In a study of peripher... | |
medium_hidden_intermediate_07554 | Pegivirus C is reported to downregulate a gene that is located in the nucleolus. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.97 and an adjusted p-value of 0.015. Which protein is encoded by this specific gene? | U3 small nucleolar RNA-associated protein 6 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07554","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the nucleolus. In a study of peripheral blood mononuclear ... | |
medium_hidden_intermediate_07555 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to Signaling by NOTCH via participation. One of these genes exhibits a log2 fold change of approximately -1.005 and an adjusted p-value of 0.01888 in a specific study. Which disease is associated with this ... | tetralogy of fallot | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07555","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to Signali... | |
medium_hidden_intermediate_07556 | Human betaherpesvirus 5 upregulates a gene that enables identical protein binding. In a study of foreskin fibroblast cell lines, this gene exhibited a log2 fold change of 1.888 and an adjusted p-value of 1.25e-07. Which biological process is this gene involved in? | ether lipid metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07556","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that enables identical protein binding. In a study of foreskin fibroblast cell li... | |
medium_hidden_intermediate_07558 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which is involved in the positive regulation of proteasomal ubiquitin-dependent protein catabolic process. This gene exhibited a log2 fold change of -1.678 and an adjusted p-value of 0.01182. Which protein i... | RING finger and CHY zinc finger domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07558","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which is in... | |
medium_hidden_intermediate_07559 | Two genes are upregulated by Human immunodeficiency virus 1 and associated with lung carcinoma. One of these genes exhibits a log2 fold change of approximately 1.233 and an adjusted p-value of 6.168e-05 in macrophages (study GSE108897). What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07559","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and associated with lung carcinoma. One of these genes exhibits ... | |
medium_hidden_intermediate_07561 | Zika virus downregulates a gene that is involved in the endosome transport via multivesicular body sorting pathway. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of approximately -1.105 and an adjusted p-value of 0.02543. Which protein is encoded by this specific gene? | DENN domain-containing protein 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07561","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the endosome transport via multivesicular body sorting pathway. In a stu... | |
medium_hidden_intermediate_07562 | CSNK2B interacts with a protein that participates in post-translational protein modification. Evidence indicates that this protein, also known by alternative aliases, is an antioxidant protein containing a Ring-H2 finger motif and interacts with the beta subunit of CKII. Which protein is encoded by this entity? | RING-box protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07562","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CSNK2B interacts with a protein that participates in post-translational protein modification. Evidence indicates that this p... | |
medium_hidden_intermediate_07563 | PSMA6 is involved in a biological process that is a type of T cell differentiation involved in immune response. Evidence for one such process describes it as the process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell, characterized by being CD4-positive, alpha-... | T-helper 17 type immune response | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07563","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PSMA6 is involved in a biological process that is a type of T cell differentiation involved in immune response. Evidence for... | |
medium_hidden_intermediate_07564 | Vaccinia virus upregulates a gene that participates in Class A/1 (Rhodopsin-like receptors). Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 3.447 and an adjusted p-value of 2.311e-08. Which disease is associated with this gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07564","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that participates in Class A/1 (Rhodopsin-like receptors). Evidence for this gene in a cer... | |
medium_hidden_intermediate_07565 | Vaccinia virus infection upregulates a gene whose protein product is located on the matrix side of the mitochondrial inner membrane. In a study of cervical adenocarcinoma cells (GSE11238), one such upregulated gene showed a log2 fold change of approximately 1.20 and an adjusted p-value of 0.0001771. Which protein is en... | Nitric oxide-associated protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07565","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus infection upregulates a gene whose protein product is located on the matrix side of the mitochondrial inner m... | |
medium_hidden_intermediate_07569 | Hepacivirus C upregulates a gene that is enriched in conventional dendritic cells. Evidence for this gene in study GSE132606 reports a log2 fold change of approximately 1.39 and an adjusted p-value of 0.00065. Which protein is encoded by this gene? | LanC-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07569","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is enriched in conventional dendritic cells. Evidence for this gene in study GSE132606... | |
medium_hidden_intermediate_07570 | Cardiovirus A upregulates a gene that participates in the Immune System. Experimental data from a cervical adenocarcinoma cell line (study GSE122967) indicates that this gene has a log2 fold change of approximately 2.36 and an adjusted p-value of approximately 0.015. Which protein is encoded by this gene? | Intercellular adhesion molecule 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07570","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A upregulates a gene that participates in the Immune System. Experimental data from a cervical adenocarcinoma ce... | |
medium_hidden_intermediate_07574 | Rift Valley fever phlebovirus upregulates a gene that is involved in the DNA damage response. In a study using SAEC cells (GSE102481), one such gene showed a log2 fold change of 2.407 and an adjusted p-value of 0.008077. Which protein is encoded by this specific gene? | Endoribonuclease ZC3H12A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07574","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rift Valley fever phlebovirus upregulates a gene that is involved in the DNA damage response. In a study using SAEC cells (G... | |
medium_hidden_intermediate_07575 | In a study of Measles morbillivirus infection, certain genes are upregulated and serve as biomarkers for stroke disorder. One such gene exhibits a log2 fold change of approximately 2.59 and an adjusted p-value of approximately 0.0107. Which protein is encoded by this specific gene? | Putative mitochondrial transporter UCP3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07575","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, certain genes are upregulated and serve as biomarkers for stroke disorder. On... | |
medium_hidden_intermediate_07576 | A gene is upregulated by Hepacivirus C and serves as a biomarker for bipolar disorder. Evidence for this gene reports a log2 fold change of 3.062 and an adjusted p-value of 0.0004932. Which protein is encoded by this gene? | G-protein coupled receptor family C group 5 member D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07576","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Hepacivirus C and serves as a biomarker for bipolar disorder. Evidence for this gene reports a log2... | |
medium_hidden_intermediate_07577 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene that participates in MAPK family signaling cascades. This gene exhibited a log2 fold change of -1.634 and an adjusted p-value of 0.01316. Which protein is encoded by this gene? | Ral guanine nucleotide dissociation stimulator-like 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07577","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_07578 | A gene is downregulated by Primate bocaparvovirus 1 and is enriched in intermediate monocytes. Evidence for this gene reports a log2 fold change of -1.370 and an adjusted p-value of 0.02094. Which protein is encoded by this gene? | Tubulin polymerization-promoting protein family member 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07578","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is enriched in intermediate monocytes. Evidence for this gene report... | |
medium_hidden_intermediate_07579 | Pegivirus C downregulates a specific gene that participates in the metabolism of vitamins and cofactors. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -1.707 and an adjusted p-value of 0.004127. What molecular function is enabled by this gene? | all-trans-retinol 13,14-reductase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07579","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene that participates in the metabolism of vitamins and cofactors. In a study of perip... | |
medium_hidden_intermediate_07580 | Rhinovirus A infection leads to the downregulation of specific genes that participate in cytokine signaling within the immune system. In a study of cytotoxic T-lymphocytes (GSE106475), one such downregulated gene exhibited a log2 fold change of -2.970 and an adjusted p-value of 0.0005891. Which protein is encoded by th... | 2'-5'-oligoadenylate synthase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07580","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of specific genes that participate in cytokine signaling within the immun... | |
medium_hidden_intermediate_07582 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that subsequently interacts with KLF3. This gene exhibited a log2 fold change of approximately 1.33 and an adjusted p-value of approximately 0.000134. Which biological process is this gene invol... | regulation of myoblast proliferation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07582","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_07583 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate a gene that participates in the degradation of the extracellular matrix. This specific gene exhibited a log2 fold change of approximately -2.71 and an adjusted p-value of 0.0103. Which protein is encoded by t... | Stromelysin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07583","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate a gene that ... | |
medium_hidden_intermediate_07584 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to classical monocytes via an 'enriched in' relationship. One of these genes exhibits a log2 fold change of -1.539 and an adjusted p-value of 0.001312 in the specified dataset. Which biological process is connecte... | antibacterial humoral response | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07584","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to classical mono... |
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