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medium_hidden_intermediate_10200 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn binds to WDR36. The expression data for this gene shows a log2 fold change of -1.208 and an adjusted p-value of 0.0174. Which protein is encoded by this gene? | U3 small nucleolar ribonucleoprotein protein IMP4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10200","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_10202 | Zika virus downregulates a gene that participates in Mitotic Prometaphase. Experimental data from glioma stem cells (study GSE114907) indicates that one such gene has a log2 fold change of approximately -1.84 and an adjusted p-value of approximately 0.019. Which protein does this specific gene product bind to? | NEK9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10202","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in Mitotic Prometaphase. Experimental data from glioma stem cells (study G... | |
medium_hidden_intermediate_10203 | Measles morbillivirus upregulates a gene that participates in the RHO GTPase cycle. Evidence for this gene in study GSE131840 reports a log2 fold change of approximately 2.08 and an adjusted p-value of 0.009257. Which protein does this gene product bind to? | PRKCI | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10203","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in the RHO GTPase cycle. Evidence for this gene in study GSE13184... | |
medium_hidden_intermediate_10204 | ESR1 interacts with a protein that is located in the cytosol. Evidence indicates that this protein is a hematopoietic PBX-interaction protein, which associates with microtubules. Which cell type is this protein enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10204","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"ESR1 interacts with a protein that is located in the cytosol. Evidence indicates that this protein is a hematopoietic PBX-in... | |
medium_hidden_intermediate_10205 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with SLC25A46. This gene exhibited a log2 fold change of 3.393 and an adjusted p-value of 2.264e-09. Which protein is encoded by this gene? | Mitochondrial fission regulator 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10205","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_10206 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables ubiquitin-protein transferase activity. Transcriptomic data for this gene in choroid plexus epithelium (study GSE157852) shows a log2 fold change of -1.757 and an adjusted p-value of 0.0006345. Which protein is encoded by this ... | Kelch-like protein 13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10206","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables ubiquitin-protein transferase a... | |
medium_hidden_intermediate_10207 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that subsequently interact with CTSS. One such gene exhibited a log2 fold change of 1.512 and an adjusted p-value of 6.726e-06. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10207","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_10208 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables transcription corepressor activity. Experimental data for this gene reports a log2 fold change of 1.588 and an adjusted p-value of 0.006406. Which cellular component is this gene located in? | chromatin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10208","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables transcription corepressor activit... | |
medium_hidden_intermediate_10210 | Two genes are downregulated by Pegivirus C and are enriched in naive B cells. One of these genes exhibits a log2 fold change of approximately -1.006 and an adjusted p-value of approximately 0.004984 in peripheral blood mononuclear cells. Which protein does this specific gene bind to? | PTPN13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10210","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and are enriched in naive B cells. One of these genes exhibits a log2 fold change... | |
medium_hidden_intermediate_10211 | Human immunodeficiency virus 1 downregulates a gene that participates in collagen formation. Evidence for this gene reports a log2 fold change of -1.923 and an adjusted p-value of 0.0152. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10211","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in collagen formation. Evidence for this gene reports ... | |
medium_hidden_intermediate_10213 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and serve as biomarkers for breast carcinoma. One of these genes exhibits a log2 fold change of approximately 1.100 and an adjusted p-value of 0.000446 in sclera cells (study GSE164073). Which biological process is this specific gene inv... | heart development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10213","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and serve as biomarkers for breast carcin... | |
medium_hidden_intermediate_10214 | Vaccinia virus upregulates a gene that interacts with PPP1CC. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 1.334 and an adjusted p-value of 2.459e-05. Which disease is associated with this gene as a biomarker? | lung cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10214","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that interacts with PPP1CC. Experimental data for this gene in a cervical adenocarcinoma c... | |
medium_hidden_intermediate_10215 | Enterovirus A infection leads to the upregulation of specific genes whose protein products are localized to the midbody. In a study of rhabdomyosarcoma cells (GSE103308), one such gene exhibited a log2 fold change of approximately 1.275 and an adjusted p-value of 0.001027. Which protein is encoded by this specific gene... | Zinc finger protein 330 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10215","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A infection leads to the upregulation of specific genes whose protein products are localized to the midbody. In ... | |
medium_hidden_intermediate_10216 | The protein DST is involved in a biological process that is a type of cytoskeleton organization. Evidence for one such process describes it as a cellular-level activity resulting in the assembly, arrangement, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins. Whic... | intermediate filament cytoskeleton | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10216","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"The protein DST is involved in a biological process that is a type of cytoskeleton organization. Evidence for one such proce... | |
medium_hidden_intermediate_10221 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with RPA3. One of these genes exhibits a log2 fold change of approximately 1.209 and an adjusted p-value of 9.275e-06 in a specific study. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10221","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with RPA3. One of these gene... | |
medium_hidden_intermediate_10222 | In a study of glioma stem cells (GSE114907), a gene is downregulated by Zika virus and binds to SPTA1. This gene exhibits a log2 fold change of approximately -1.52 and an adjusted p-value of 0.0175. Which protein is encoded by this gene? | Conserved oligomeric Golgi complex subunit 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10222","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), a gene is downregulated by Zika virus and binds to SPTA1. This gene exhibits a ... | |
medium_hidden_intermediate_10223 | A gene is upregulated by Primate bocaparvovirus 1 and is associated with systemic lupus erythematosus. Experimental evidence for this gene reports a log2 fold change of approximately 1.02 and an adjusted p-value of approximately 0.0345. Which disease is linked to this gene via a biomarker relationship? | myelodysplastic syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10223","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is associated with systemic lupus erythematosus. Experimental evidence... | |
medium_hidden_intermediate_10224 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to retinoblastoma via an association. One of these genes was reported in a study (GSE151803) using a pancreatic cell line, with a log2 fold change of -1.195 and an adjusted p-value of 0.03912. Which prote... | Actin-binding protein IPP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10224","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to retin... | |
medium_hidden_intermediate_10226 | Pegivirus C downregulates a gene that participates in the synthesis of PIPs at the plasma membrane. Experimental data from peripheral blood mononuclear cells (study GSE131504) indicate that this gene has a log2 fold change of approximately -1.031 and an adjusted p-value of 0.005202. Which protein is encoded by this gen... | Phosphatidylinositol 4-kinase type 2-beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10226","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in the synthesis of PIPs at the plasma membrane. Experimental data from p... | |
medium_hidden_intermediate_10227 | A gene is upregulated by Primate bocaparvovirus 1 and participates in Dengue Virus-Host Interactions. Evidence for this gene reports a log2 fold change of 1.159 and an adjusted p-value of 0.03197. Which cell type is this gene enriched in? | naive B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10227","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in Dengue Virus-Host Interactions. Evidence for this gene... | |
medium_hidden_intermediate_10228 | Human immunodeficiency virus 1 downregulates a gene that participates in tRNA processing. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately -1.099 and an adjusted p-value of 0.005976. Which biological process is this gene involved in? | mRNA processing | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10228","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in tRNA processing. Evidence for this gene in macropha... | |
medium_hidden_intermediate_10231 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and participates in PIWI-interacting RNA (piRNA) biogenesis. This specific gene exhibits a log2 fold change of 1.463 and an adjusted p-value of 2.673e-05. Which protein is encoded by this gene? | Mitochondrial cardiolipin hydrolase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10231","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and participates in PIW... | |
medium_hidden_intermediate_10232 | Zika virus infection has been shown to upregulate certain genes that are involved in central nervous system development. One such gene exhibits a log2 fold change of approximately 1.81 and an adjusted p-value of 0.017 in neural stem cells. Which protein is encoded by this specific gene? | Neuronal pentraxin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10232","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection has been shown to upregulate certain genes that are involved in central nervous system development. One... | |
medium_hidden_intermediate_10235 | Two genes are structurally linked to Enterovirus A via downregulation and to Hemostasis via participation. One of these genes exhibits a log2 fold change of -1.319 and an adjusted p-value of 0.02785 in rhabdomyosarcoma cells. Which disease is associated with this specific gene through genomic alterations? | ovarian neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10235","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via downregulation and to Hemostasis via participation. One of these gene... | |
medium_hidden_intermediate_10236 | In a study of SAEC cells (GSE153218), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that participates in Sensory Perception. One such gene exhibited a log2 fold change of 1.516 and an adjusted p-value of 0.01825. Which protein is encoded by this specific gene? | Taperin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10236","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of SAEC cells (GSE153218), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene t... | |
medium_hidden_intermediate_10238 | A gene is upregulated by Human gammaherpesvirus 8 and enriched in eosinophils. Evidence for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of 1.261 and an adjusted p-value of 0.009392. Which disease is associated with this gene? | polyarticular arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10238","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and enriched in eosinophils. Evidence for this gene in a non-Hodgkin lymph... | |
medium_hidden_intermediate_10239 | Two genes are upregulated by Vaccinia virus and serve as biomarkers for breast carcinoma. One of these genes exhibits a log2 fold change of 2.083 and an adjusted p-value of 8.89e-07 in cervical adenocarcinoma cell lines (study GSE11238). Which gene interacts with the gene identified by these specific expression statist... | MRPS16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10239","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and serve as biomarkers for breast carcinoma. One of these genes exhibits a log2... | |
medium_hidden_intermediate_10241 | Measles morbillivirus upregulates a gene that participates in Asparagine N-linked glycosylation. Evidence for one such gene reports a log2 fold change of 1.214 and an adjusted p-value of 0.03323. Which protein is encoded by that gene? | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10241","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in Asparagine N-linked glycosylation. Evidence for one such gene ... | |
medium_hidden_intermediate_10242 | Human alphaherpesvirus 3 is known to upregulate multiple genes that are involved in the positive regulation of cell population proliferation. One such gene exhibits a log2 fold change of 1.515 and an adjusted p-value of 3.908e-05 in a melanoma cell line study (GSE136586). Which protein is encoded by this specific gene? | Melanoma antigen preferentially expressed in tumors | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10242","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is known to upregulate multiple genes that are involved in the positive regulation of cell populati... | |
medium_hidden_intermediate_10243 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that participates in post-translational protein phosphorylation. This gene exhibited a log2 fold change of approximately 1.25 and an adjusted p-value of approximately 1.85e-05. Which protein is ... | Nucleobindin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10243","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_10248 | A gene serves as a marker for Ciliated epithelial cells and is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for one such gene reports a mean expression of 2.53 TPM, a z-score of 2.50, and a fold enrichment of 8.35. Which biological process is this gene involved in? | female pregnancy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10248","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Ciliated epithelial cells and is enriched in Mucosa-associated invariant T (MAIT) cells. Evide... | |
medium_hidden_intermediate_10250 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with SSBP1. One of these genes shows a log2 fold change of 1.262 and an adjusted p-value of 0.00539 in a specific study. Which protein is encoded by this gene? | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10250","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with SSBP1. One of these gen... | |
medium_hidden_intermediate_10251 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in cytoskeleton organization. Experimental data for this gene shows a log2 fold change of 1.070 and an adjusted p-value of 0.000269. Which disease is associated with this gene through genomic alterations? | hemolytic anemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10251","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in cytoskeleton organization.... | |
medium_hidden_intermediate_10255 | Hepacivirus C upregulates a gene that subsequently interacts with BAG6. Experimental data for one such intermediate gene reports a log2 fold change of 1.124 and an adjusted p-value of 0.0001854. Which protein is encoded by this specific gene? | Mitogen-activated protein kinase 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10255","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that subsequently interacts with BAG6. Experimental data for one such intermediate gene rep... | |
medium_hidden_intermediate_10256 | A gene serves as a marker for Myeloid conventional dendritic cells and is enriched in Intermediate monocytes. Evidence for this gene includes a mean expression of 106.98 TPM, a z-score of 1.55, and a fold enrichment of 4.88. Which disease is associated with this gene through genomic alterations? | coronary artery disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10256","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Myeloid conventional dendritic cells and is enriched in Intermediate monocytes. Evidence for t... | |
medium_hidden_intermediate_10258 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that is located in the ubiquitin ligase complex. One such gene exhibited a log2 fold change of 1.455 and an adjusted p-value of 0.008307. Which protein is encoded by this specific gen... | Muskelin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10258","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_10259 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in autophagy. Experimental data for this gene in bronchial epithelial cells shows a log2 fold change of 1.693 and an adjusted p-value of 0.02943. Which disease is associated with this gene as a biomarker? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10259","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in autophagy. Experimental da... | |
medium_hidden_intermediate_10264 | Two genes are structurally linked from Influenza A virus to acute myeloid leukemia via an upregulation relationship followed by a biomarker association. One of these genes is reported in a study (GSE147507) involving bronchial epithelial cells, with a log2 fold change of approximately 3.326 and an adjusted p-value of 6... | Protein sprouty homolog 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10264","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Influenza A virus to acute myeloid leukemia via an upregulation relationship followed... | |
medium_hidden_intermediate_10266 | Two genes are structurally linked from Pegivirus C to peritonitis via a downregulation relationship followed by an association. One of these genes has a reported log2 fold change of -1.722 and an adjusted p-value of 0.0003473 in peripheral blood mononuclear cells. Which protein is encoded by the gene matching these sta... | N-formyl peptide receptor 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10266","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Pegivirus C to peritonitis via a downregulation relationship followed by an associati... | |
medium_hidden_intermediate_10267 | A gene is upregulated by Measles morbillivirus and participates in Developmental Biology. Evidence for this gene reports a log2 fold change of 1.615 and an adjusted p-value of 0.01345. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10267","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and participates in Developmental Biology. Evidence for this gene reports a l... | |
medium_hidden_intermediate_10268 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that interacts with YWHAB. One such gene exhibits a log2 fold change of 1.445 and an adjusted p-value of 0.0024. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10268","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that interacts with YWHAB. One such... | |
medium_hidden_intermediate_10269 | Hepacivirus C upregulates a gene that participates in the transport of small molecules. Evidence for this gene in hepatocytes (study GSE132606) reports a log2 fold change of approximately 3.08 and an adjusted p-value of 0.0012. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10269","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the transport of small molecules. Evidence for this gene in hepatocyte... | |
medium_hidden_intermediate_10270 | Human immunodeficiency virus 1 downregulates a gene that is involved in the ERAD pathway. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.51 and an adjusted p-value of 0.001489. Which protein is encoded by this gene? | Selenoprotein S | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10270","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in the ERAD pathway. In a study of macrophages (GSE1088... | |
medium_hidden_intermediate_10271 | Human polyomavirus 1 upregulates a gene that is located in the nucleus. Experimental data from study GSE135833 in renal epithelial cells indicates that this gene has a log2 fold change of 2.255 and an adjusted p-value of 0.03891. Which gene interacts with this upregulated nuclear gene? | GIT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10271","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 upregulates a gene that is located in the nucleus. Experimental data from study GSE135833 in renal epit... | |
medium_hidden_intermediate_10272 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables small GTPase binding. Evidence for this gene reports a log2 fold change of 1.383 and an adjusted p-value of 0.03448. Which protein is encoded by this gene? | Rho-related GTP-binding protein RhoH | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10272","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables small GTPase binding. Evidence for thi... | |
medium_hidden_intermediate_10273 | Clemastine interacts with two different drugs, both of which also interact with Physostigmine. One of these intermediate drugs is associated with clinical evidence stating: 'In two of these patients, symptoms responded to treatment with physostigmine.' What disease is the drug associated with this evidence indicated fo... | fibromyalgia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10273","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Clemastine interacts with two different drugs, both of which also interact with Physostigmine. One of these intermediate dru... | |
medium_hidden_intermediate_10275 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to downregulate a specific gene involved in protein metabolism. This gene exhibited a log2 fold change of approximately -1.415 and an adjusted p-value of 0.009257. Which protein is encoded by this gene? | Cytosolic endo-beta-N-acetylglucosaminidase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10275","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to downregulate a specific gene i... | |
medium_hidden_intermediate_10276 | Human betaherpesvirus 5 upregulates a gene that is involved in protein autoubiquitination. Evidence for one such gene reports a log2 fold change of 1.106 and an adjusted p-value of 0.0002217. Which protein is encoded by that gene? | E3 ubiquitin-protein ligase RNF19B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10276","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is involved in protein autoubiquitination. Evidence for one such gene report... | |
medium_hidden_intermediate_10277 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of a specific gene, which in turn interacts with the protein YWHAE. The downregulated gene exhibits a log2 fold change of approximately -1.16 and an adjusted p-value of 0.0179. Which protein is encoded by this downregu... | LIM domain only protein 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10277","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of a specific gene, wh... | |
medium_hidden_intermediate_10278 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are enriched in Mucosa-associated invariant T (MAIT) cells. One of these genes exhibits a log2 fold change of -2.051 and an adjusted p-value of 0.000737 in lung tissue. Which protein is encoded by this specific gene? | Immunoglobulin superfamily member 22 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10278","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are enriched in Mucosa-associated i... | |
medium_hidden_intermediate_10280 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Aerobic respiration and respiratory electron transport. Evidence for this gene reports a log2 fold change of 1.022 and an adjusted p-value of 0.0001413. Which disease is associated with this gene as a biomarker? | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10280","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Aerobic respiration and r... | |
medium_hidden_intermediate_10281 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to Regulatory T (Treg) cells via an 'enriched in' relationship. One of these genes exhibits a log2 fold change of -4.665 and an adjusted p-value of 0.005976 in the specified context. Which molecular function is en... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10281","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to Regulatory T (... | |
medium_hidden_intermediate_10282 | Pegivirus C downregulates a gene that is located in the Golgi membrane. Evidence for this specific gene reports a log2 fold change of -1.545 and an adjusted p-value of 0.002355. Which molecular function is enabled by this gene? | signaling receptor binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10282","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that is located in the Golgi membrane. Evidence for this specific gene reports a log2 fold ... | |
medium_hidden_intermediate_10285 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that participates in insulin receptor recycling. This specific gene exhibited a log2 fold change of 3.061 and an adjusted p-value of 0.002051. Which protein is encoded by this gene? | V-type proton ATPase subunit e 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10285","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that participates i... | |
medium_hidden_intermediate_10286 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that subsequently binds to WNT11. One such gene exhibited a log2 fold change of -1.362 and an adjusted p-value of 0.007694. Which protein is encoded by this specific gene? | Frizzled-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10286","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that subsequently bin... | |
medium_hidden_intermediate_10287 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Potassium Channels. Evidence for this gene reports a log2 fold change of -1.476 and an adjusted p-value of 0.01718. Which disease is associated with this gene as a biomarker? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10287","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Potassium Channels. Evi... | |
medium_hidden_intermediate_10288 | Hepacivirus C upregulates a specific gene that participates in gene expression (transcription). Evidence for this gene reports a log2 fold change of approximately 2.48 and an adjusted p-value of 0.0284. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10288","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a specific gene that participates in gene expression (transcription). Evidence for this gene repor... | |
medium_hidden_intermediate_10290 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and is involved in cell adhesion. This specific gene exhibits a log2 fold change of 2.446 and an adjusted p-value of 0.0005028. Which protein is encoded by this gene? | Neurotrimin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10290","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and is involved in cell adhes... | |
medium_hidden_intermediate_10292 | Two genes are downregulated by Human betaherpesvirus 5 and are enriched in neutrophils. One of these genes exhibits a log2 fold change of approximately -2.154 and an adjusted p-value of 0.0047 in foreskin fibroblast cell lines. Which disease is associated with this specific gene as a biomarker? | autosomal recessive nonsyndromic hearing loss 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10292","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human betaherpesvirus 5 and are enriched in neutrophils. One of these genes exhibits a log2 f... | |
medium_hidden_intermediate_10294 | Pegivirus C downregulates a gene that subsequently interacts with PPP2CB. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of approximately -2.14 and an adjusted p-value of approximately 0.00025. Which protein is encoded by this gene? | Protein PRR14L | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10294","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that subsequently interacts with PPP2CB. Experimental data for this intermediate gene in pe... | |
medium_hidden_intermediate_10295 | A gene is downregulated by Primate bocaparvovirus 1 and interacts with AIFM1. Experimental data for this gene in umbilical vein endothelial cells (study GSE119608) shows a log2 fold change of approximately -1.125 and an adjusted p-value of 0.005189. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10295","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and interacts with AIFM1. Experimental data for this gene in umbilical v... | |
medium_hidden_intermediate_10297 | Hepacivirus C downregulates a gene that subsequently interacts with MAPRE1. Experimental data for this intermediate gene in peripheral blood mononuclear cells (study GSE119117) reports a log2 fold change of approximately -1.144 and an adjusted p-value of 0.000226. Which protein is encoded by this gene? | Sperm-associated antigen 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10297","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that subsequently interacts with MAPRE1. Experimental data for this intermediate gene in ... | |
medium_hidden_intermediate_10299 | Nerve Sheath Neoplasms are localized to anatomical structures that are ectoderm-derived. One such structure is described as the cranial ganglion associated with and extending fibers into the trigeminal nerve. Which anatomy is the immediate transformation of this specific structure? | future trigeminal ganglion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10299","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Nerve Sheath Neoplasms are localized to anatomical structures that are ectoderm-derived. One such structure is described as ... | |
medium_hidden_intermediate_10301 | In a study of colonic adenocarcinoma cells (GSE148729), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which in turn encodes a protein that binds to RPA1. The upregulation of this gene was associated with a log2 fold change of approximately 2.17 and an adjusted p-value of... | DNA polymerase alpha catalytic subunit | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10301","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of colonic adenocarcinoma cells (GSE148729), Severe acute respiratory syndrome-related coronavirus was found to u... | |
medium_hidden_intermediate_10302 | Human alphaherpesvirus 3 downregulates a specific gene that enables protein binding. In a study of melanoma cell lines (GSE136586), this gene exhibited a log2 fold change of -1.225 and an adjusted p-value of 1.975e-05. Which biological process is this gene involved in? | negative regulation of T cell receptor signaling pathway | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10302","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 downregulates a specific gene that enables protein binding. In a study of melanoma cell lines (GSE1... | |
medium_hidden_intermediate_10303 | Zika virus infection leads to the downregulation of certain genes that encode proteins with ATP hydrolysis activity. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.412 and an adjusted p-value of 0.02491. Which protein is encoded by this specific gene? | ATPase WRNIP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10303","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of certain genes that encode proteins with ATP hydrolysis activity. In a st... | |
medium_hidden_intermediate_10304 | Zika virus downregulates a specific gene that is involved in the immune response. Experimental data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of approximately -3.31 and an adjusted p-value of 0.0144. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10304","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the immune response. Experimental data from glioma stem cells (... | |
medium_hidden_intermediate_10306 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Phospholipid metabolism. Transcriptomic data for this gene shows a log2 fold change of approximately -1.225 and an adjusted p-value of 0.008277. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10306","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Phospholipid metabolism... | |
medium_hidden_intermediate_10307 | Human immunodeficiency virus 1 upregulates a gene that interacts with RAC1. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately 1.55 and an adjusted p-value of 1.095e-05. Which disease is associated with this gene? | lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10307","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that interacts with RAC1. Evidence for this gene in macrophages (from stud... | |
medium_hidden_intermediate_10308 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with PRNP. One such gene exhibits a log2 fold change of approximately 1.64 and an adjusted p-value of 5.133e-06. Which protein is encoded by this specific gene? | Adenosylhomocysteinase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10308","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with PR... | |
medium_hidden_intermediate_10309 | In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are upregulated and subsequently linked to thyroid tumor via genomic alterations. One such gene exhibits a log2 fold change of 2.431 and an adjusted p-value of 0.02856 in lung cells. Which protein is encoded by this specific ge... | Oxoeicosanoid receptor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10309","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are upregulated and subsequentl... | |
medium_hidden_intermediate_10311 | Zika virus upregulates a gene that participates in the Immune System. Evidence for one such gene reports a log2 fold change of 1.593 and an adjusted p-value of 0.01315. Which disease is associated with this gene as a biomarker? | bacterial pneumonia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10311","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in the Immune System. Evidence for one such gene reports a log2 fold change ... | |
medium_hidden_intermediate_10312 | Zika virus downregulates a specific gene that is involved in protein maturation. Experimental data for this gene shows a log2 fold change of -3.107 and an adjusted p-value of 0.002635. In which cell type is this gene enriched? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10312","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in protein maturation. Experimental data for this gene shows a log... | |
medium_hidden_intermediate_10313 | In a study of peripheral blood mononuclear cells (GSE131504), Pegivirus C infection was found to downregulate a specific gene that participates in aerobic respiration and respiratory electron transport. This gene exhibited a log2 fold change of -1.092 and an adjusted p-value of 0.02751. Which protein is encoded by this... | Mitochondrial proton/calcium exchanger protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10313","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), Pegivirus C infection was found to downregulate a specific gen... | |
medium_hidden_intermediate_10314 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Phase II - Conjugation of compounds. One such gene exhibits a log2 fold change of approximately 2.886 and an adjusted p-value of 0.02277. Which protein is encoded by this specific gene? | Sulfotransferase 1C4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10314","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Phase II - Con... | |
medium_hidden_intermediate_10315 | A gene is downregulated by Vaccinia virus and participates in a disease. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -2.22 and an adjusted p-value of 0.0072. Which disease is associated with this gene through genomic alterations? | colorectal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10315","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Vaccinia virus and participates in a disease. Evidence for this gene in a cervical adenocarcinoma... | |
medium_hidden_intermediate_10316 | Zika virus infection leads to the downregulation of certain genes that are involved in visual perception. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.876 and an adjusted p-value of 0.01422. Which protein is encoded by this specific gene? | Kinesin-like protein KIFC3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10316","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of certain genes that are involved in visual perception. In a study of glio... | |
medium_hidden_intermediate_10317 | Human betaherpesvirus 5 is known to downregulate a specific gene that enables calcium ion binding. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE111036) reports a log2 fold change of approximately -1.208 and an adjusted p-value of 0.04666. Which disease is associated with this gene as... | basal-like breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10317","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate a specific gene that enables calcium ion binding. Experimental data for thi... | |
medium_hidden_intermediate_10318 | Hepacivirus C downregulates a gene that is located in the extracellular region. Evidence for one such gene reports a log2 fold change of -1.235 and an adjusted p-value of 0.009446. Which gene interacts with this specific downregulated gene? | UCK1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10318","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that is located in the extracellular region. Evidence for one such gene reports a log2 fo... | |
medium_hidden_intermediate_10319 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and participates in post-translational protein modification. This gene exhibits a log2 fold change of 1.003 and an adjusted p-value of 1.492e-09. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10319","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and p... | |
medium_hidden_intermediate_10321 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with YBX1. One of these genes shows a log2 fold change of approximately 1.37 and an adjusted p-value of 0.0094 in a specific study. Which biological process is this gene involved in? | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10321","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with YBX1. One of these gene... | |
medium_hidden_intermediate_10322 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Peroxisomal lipid metabolism. One of these genes has a reported log2 fold change of 1.013 and an adjusted p-value of 0.03543. Which cell type is enriched for this specific gene? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10322","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Peroxisomal lipid meta... | |
medium_hidden_intermediate_10323 | Zika virus downregulates a gene involved in monocarboxylic acid transport. Evidence for one such gene reports a log2 fold change of -1.843 and an adjusted p-value of 0.02011. Which protein is encoded by that gene? | Monocarboxylate transporter 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10323","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene involved in monocarboxylic acid transport. Evidence for one such gene reports a log2 fold ch... | |
medium_hidden_intermediate_10324 | Zika virus downregulates a specific gene that is enriched in regulatory T (Treg) cells. Evidence for this gene reports a log2 fold change of -1.082 and an adjusted p-value of 0.03338. Which molecular function is enabled by this gene? | enzyme binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10324","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is enriched in regulatory T (Treg) cells. Evidence for this gene reports a log... | |
medium_hidden_intermediate_10326 | In a study of sclera cells (GSE164073), a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables tau-protein kinase activity. This specific gene exhibits a log2 fold change of 1.013 and an adjusted p-value of 0.02714. Which protein is encoded by this gene? | Serine/threonine-protein kinase MARK1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10326","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of sclera cells (GSE164073), a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and e... | |
medium_hidden_intermediate_10328 | Zika virus downregulates a gene that is involved in the collagen biosynthetic process. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.629 and an adjusted p-value of 0.005538. Which protein is encoded by this specific gene? | Translocating chain-associated membrane protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10328","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the collagen biosynthetic process. In a study of glioma stem cells (GSE1... | |
medium_hidden_intermediate_10330 | In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and serving as a biomarker for lung carcinoma. This specific gene exhibits a log2 fold change of -3.461 and an adjusted p-value of 0.01955. Which protein is encoded by this gene? | Tumor necrosis factor alpha-induced protein 8-like protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10330","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and ser... | |
medium_hidden_intermediate_10331 | KRT84 is involved in a biological process that is a type of anatomical structure development. One such process is defined as the progression of the hair follicle over time, from its formation to the mature structure, where a hair follicle is a tube-like opening in the epidermis. Which biological process is this entity ... | skin epidermis development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10331","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"KRT84 is involved in a biological process that is a type of anatomical structure development. One such process is defined as... | |
medium_hidden_intermediate_10332 | Zika virus downregulates a specific gene that is involved in the positive regulation of TORC1 signaling. Experimental data from glioma stem cells (study GSE114907) indicate that this gene has a log2 fold change of approximately -1.145 and an adjusted p-value of 0.03907. Which gene binds to the target of this downregula... | WDR59 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10332","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the positive regulation of TORC1 signaling. Experimental data f... | |
medium_hidden_intermediate_10333 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which in turn enables protein kinase inhibitor activity. This gene exhibited a log2 fold change of approximately 1.196 and an adjusted p-value of 0.008793. Which protein is encoded by this gene? | Guanine nucleotide exchange protein SMCR8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10333","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which in ... | |
medium_hidden_intermediate_10334 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with DYRK1B. Evidence for one such gene reports a log2 fold change of 2.278 and an adjusted p-value of 0.02778. Which protein is encoded by that gene? | Protein FAM117A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10334","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with DYRK1B. Evidence for one such g... | |
medium_hidden_intermediate_10335 | A gene is upregulated by Measles morbillivirus and is involved in DNA synthesis involved in DNA repair. Evidence for this gene in pleural mesothelioma cells reports a log2 fold change of 2.689 and an adjusted p-value of 0.00448. Which disease is associated with this gene? | thymoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10335","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and is involved in DNA synthesis involved in DNA repair. Evidence for this ge... | |
medium_hidden_intermediate_10336 | Influenza A virus upregulates a gene that is located in the extracellular exosome. Evidence for one such gene reports a log2 fold change of 1.779 and an adjusted p-value of 2.927e-09. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10336","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Influenza A virus upregulates a gene that is located in the extracellular exosome. Evidence for one such gene reports a log2... | |
medium_hidden_intermediate_10337 | In a study of Influenza A virus infection, a specific gene is downregulated by the virus and participates in hemostasis. Evidence for this gene reports a log2 fold change of -1.031 and an adjusted p-value of 2.702e-07. Which protein is encoded by this gene? | Chitinase domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10337","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is downregulated by the virus and participates in hemostasis. Evi... | |
medium_hidden_intermediate_10338 | Two genes are structurally linked to Hepacivirus C via a 'downregulates' relationship and to COPI-dependent Golgi-to-ER retrograde traffic via a 'participates in' relationship. One of these genes has an associated expression profile showing a log2 fold change of -1.366 and an adjusted p-value of 0.000461. Which disease... | early-childhood-onset neurodegeneration with retinitis pigmentosa, sensorineural hearing loss, and demyelinating peripheral neuropathy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10338","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Hepacivirus C via a 'downregulates' relationship and to COPI-dependent Golgi-to-ER retr... | |
medium_hidden_intermediate_10339 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participates in Peptide ligand-binding receptors. Evidence for this gene reports a log2 fold change of 2.334 and an adjusted p-value of 0.02038. Which protein is encoded by this gene? | C-C motif chemokine 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10339","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participat... | |
medium_hidden_intermediate_10341 | Pegivirus C is reported to downregulate a specific gene that participates in Hemostasis. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -1.135 and an adjusted p-value of 0.002897. Which gene interacts with this downregulated entity? | CDC42 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10341","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that participates in Hemostasis. In a study of peripheral blood mono... | |
medium_hidden_intermediate_10342 | Hepacivirus C is reported to downregulate a specific gene, which in turn enables identical protein binding. Experimental data for this gene indicates a log2 fold change of approximately -1.275 and an adjusted p-value of 0.0001823. Which disease is associated with this gene as a biomarker? | clear cell renal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10342","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which in turn enables identical protein binding. Experimental dat... | |
medium_hidden_intermediate_10343 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific gene that participates in UCH proteinases. This gene exhibits a log2 fold change of approximately 2.97 and an adjusted p-value of 0.0031. Which protein is encoded by this gene? | Histone H2A type 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10343","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific gene that participates in... | |
medium_hidden_intermediate_10345 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in tRNA modification in the nucleus and cytosol. Experimental evidence for this gene reports a log2 fold change of -1.560 and an adjusted p-value of 0.002812. Which molecular function is enabled by this gene? | tRNA methyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10345","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in tRNA modification in th... |
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