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medium_hidden_intermediate_10042 | Two genes are upregulated by Human immunodeficiency virus 1 and are associated with cervical carcinoma. One of these genes exhibits a log2 fold change of 2.234 and an adjusted p-value of 0.001351 in macrophages (study GSE108897). Which protein is encoded by this specific gene? | Prostaglandin E2 receptor EP2 subtype | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10042","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and are associated with cervical carcinoma. One of these genes e... | |
medium_hidden_intermediate_10043 | Zika virus downregulates multiple genes that participate in the processing of capped intron-containing pre-mRNA. One such gene exhibits a log2 fold change of approximately -2.03 and an adjusted p-value of 0.0065 in glioma stem cells. Which protein interacts with this specific gene product? | PRKN | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10043","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates multiple genes that participate in the processing of capped intron-containing pre-mRNA. One such ge... | |
medium_hidden_intermediate_10044 | Zika virus infection leads to the upregulation of certain genes whose protein products are located in the plasma membrane. In a study of neural stem cells (GSE129180), one such gene exhibited a log2 fold change of approximately 1.147 and an adjusted p-value of 0.03011. Which protein is encoded by this specific gene? | T cell receptor alpha chain constant | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10044","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the upregulation of certain genes whose protein products are located in the plasma membrane. I... | |
medium_hidden_intermediate_10046 | Two distinct biological processes serve as intermediate categories linking 'negative regulation of oogenesis' to 'negative regulation of biological process' via 'is a' relationships. One of these intermediate processes is defined by the evidence: 'Any process that stops, prevents or reduces the frequency, rate or exten... | reproductive process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10046","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct biological processes serve as intermediate categories linking 'negative regulation of oogenesis' to 'negative r... | |
medium_hidden_intermediate_10048 | Hepacivirus C downregulates a gene that subsequently interacts with TCF4. Experimental data for one such gene reports a log2 fold change of -1.671 and an adjusted p-value of 0.0005728. Which protein is encoded by this gene? | DNA-binding protein inhibitor ID-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10048","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that subsequently interacts with TCF4. Experimental data for one such gene reports a log2... | |
medium_hidden_intermediate_10049 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in sphingolipid metabolism. Transcriptomic data for this gene shows a log2 fold change of approximately 1.32 and an adjusted p-value of approximately 0.014. Which protein is encoded by this gene? | Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10049","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in sphingolipid ... | |
medium_hidden_intermediate_10050 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its protein product interacts with RAB11A. Experimental data for this gene reports a log2 fold change of approximately 1.295 and an adjusted p-value of 0.01617. Which protein is encoded by this gene? | Rab11 family-interacting protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10050","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its protein product interacts... | |
medium_hidden_intermediate_10051 | Hepacivirus C is associated with the downregulation of a gene that participates in the M Phase. Experimental data for this gene reports a log2 fold change of -1.213 and an adjusted p-value of 0.002642. Which protein is encoded by this gene? | Condensin-2 complex subunit H2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10051","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the downregulation of a gene that participates in the M Phase. Experimental data for this g... | |
medium_hidden_intermediate_10052 | Hepacivirus C is reported to downregulate a gene that enables DNA-binding transcription factor activity. Experimental data for one such gene shows a log2 fold change of -1.128 and an adjusted p-value of 0.001455. Which protein is encoded by this gene? | Zinc finger protein 175 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10052","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that enables DNA-binding transcription factor activity. Experimental data f... | |
medium_hidden_intermediate_10053 | Human immunodeficiency virus 1 downregulates a gene that enables protein tyrosine phosphatase activity. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -1.605 and an adjusted p-value of 0.00457. Which disease is associated with genomic alterations in this specific gene? | Burkitt lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10053","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that enables protein tyrosine phosphatase activity. In a study of macrop... | |
medium_hidden_intermediate_10054 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in chemical synaptic transmission. Evidence for one such gene reports a log2 fold change of 1.088 and an adjusted p-value of 0.0001446. Which protein does this gene product bind to? | VAMP2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10054","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in chemical synaptic transmission.... | |
medium_hidden_intermediate_10058 | Hepacivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of transcription by RNA polymerase II. Experimental data for this gene indicates a log2 fold change of -1.754 and an adjusted p-value of 0.01857. In which cell type is this gene enriched? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10058","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of tran... | |
medium_hidden_intermediate_10059 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is identified as being downregulated by Vaccinia virus and involved in mRNA splicing via the spliceosome. This specific gene exhibits a log2 fold change of approximately -1.60 and an adjusted p-value of approximately 0.049. Which disease is associated ... | mosaic variegated aneuploidy syndrome 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10059","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is identified as being downregulated by Vaccinia virus a... | |
medium_hidden_intermediate_10060 | Zika virus downregulates a specific gene that subsequently interacts with RPA3. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -3.92 and an adjusted p-value of 0.0067. Which cellular component is this gene located in? | nuclear replication fork | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10060","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that subsequently interacts with RPA3. In a study of glioma stem cells (GSE114907),... | |
medium_hidden_intermediate_10062 | In a study of macrophages (GSE108897), a gene upregulated by Human immunodeficiency virus 1 and associated with disease exhibits a log2 fold change of approximately 4.51 and an adjusted p-value of 0.0012. Which biological process is this gene involved in? | negative regulation of cell population proliferation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10062","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene upregulated by Human immunodeficiency virus 1 and associated with disease exhi... | |
medium_hidden_intermediate_10063 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and enables tubulin binding. This specific gene exhibits a log2 fold change of approximately 1.58 and an adjusted p-value of approximately 0.0187. Which protein is encoded by this gene? | Neurocalcin-delta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10063","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and enables tubulin bin... | |
medium_hidden_intermediate_10065 | Two genes are downregulated by Zika virus and participate in Mitotic Prometaphase. One of these genes exhibits a log2 fold change of -1.273 and an adjusted p-value of 0.03263 in glioma stem cells. Which disease is associated with this specific gene as a biomarker? | congenital diarrhea 5 with tufting enteropathy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10065","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Zika virus and participate in Mitotic Prometaphase. One of these genes exhibits a log2 fold c... | |
medium_hidden_intermediate_10067 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and binds to GNB1. Evidence for this gene reports a log2 fold change of -1.766 and an adjusted p-value of 0.03511. Which cellular component is this gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10067","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and binds to GNB1. Evidence for this gene r... | |
medium_hidden_intermediate_10069 | Cardiovirus A upregulates a gene that is located in the extracellular space. Evidence for one such gene reports a log2 fold change of 1.069 and an adjusted p-value of 0.03422. Which disease is associated with that gene? | hyperplasia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10069","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A upregulates a gene that is located in the extracellular space. Evidence for one such gene reports a log2 fold ... | |
medium_hidden_intermediate_10070 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), a gene upregulated by Influenza A virus and involved in protein metabolism was found to have a log2 fold change of 1.098 and an adjusted p-value of 0.007984. Which disease is associated with this gene as a biomarker? | familial hyperaldosteronism | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10070","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), a gene upregulated by Influenza A virus and involve... | |
medium_hidden_intermediate_10071 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the RAF/MAP kinase cascade. One of these genes was reported in a study using a pancreatic cell line (GSE151803) with a log2 fold change of 1.279 and an adjusted p-value of 0.02652. Which protein is encoded by this spec... | Fibroblast growth factor 18 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10071","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the RAF/MAP kinase cas... | |
medium_hidden_intermediate_10074 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with DYRK1A. One such gene exhibits a log2 fold change of approximately 1.44 and an adjusted p-value of 0.012. Which protein is encoded by this specific gene? | Glucocorticoid-induced transcript 1 protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10074","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with DY... | |
medium_hidden_intermediate_10076 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the EMILIN complex. Evidence for this gene reports a log2 fold change of -1.473 and an adjusted p-value of 0.0006068. Which protein is encoded by this gene? | EMILIN-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10076","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the EMILIN complex. Evidence f... | |
medium_hidden_intermediate_10080 | A specific gene is expressed in Natural killer T (NKT) cells and enables ubiquitin-like ligase-substrate adaptor activity. Evidence indicates that the protein product of this gene may provide an alternate maintenance pathway for modified proteins in mammalian cells by acting as an E3 ubiquitin ligase adaptor protein. W... | angle-closure glaucoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10080","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific gene is expressed in Natural killer T (NKT) cells and enables ubiquitin-like ligase-substrate adaptor activity. E... | |
medium_hidden_intermediate_10081 | Human alphaherpesvirus 1 upregulates a specific gene that participates in the Maternal to zygotic transition (MZT). Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that this gene has a log2 fold change of approximately 2.27 and an adjusted p-value of approximately 0.0074. Which protein... | Histone H2A type 1-D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10081","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a specific gene that participates in the Maternal to zygotic transition (MZT). Experime... | |
medium_hidden_intermediate_10082 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with breast carcinoma. One of these genes exhibits a log2 fold change of -3.162 and an adjusted p-value of 0.02441 in a specific study. Which cell type is enriched for this specific gene? | intermediate monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10082","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with breast carcinom... | |
medium_hidden_intermediate_10086 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the mitochondrial matrix. Evidence for this gene reports a log2 fold change of 1.169 and an adjusted p-value of 0.04651. Which protein is encoded by this gene? | rRNA methyltransferase 1, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10086","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the mitochondrial matrix. Eviden... | |
medium_hidden_intermediate_10087 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the negative regulation of inflammatory response. Evidence for one such gene reports a log2 fold change of -1.393 and an adjusted p-value of 0.003601. Which protein is encoded by that gene? | Thymosin beta-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10087","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the negative regulation of in... | |
medium_hidden_intermediate_10088 | Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of DNA-templated transcription. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this specific gene has a log2 fold change of approximately -1.82 and an adjusted p-value of approxima... | NIF3-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10088","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of DNA-templated transcription. E... | |
medium_hidden_intermediate_10091 | Zika virus downregulates a gene that is involved in endocytic recycling. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -1.81 and an adjusted p-value of approximately 0.034. Which protein is encoded by this specific gene? | COMM domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10091","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in endocytic recycling. In a study of glioma stem cells (GSE114907), one su... | |
medium_hidden_intermediate_10092 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in trans-Golgi Network Vesicle Budding. Evidence for this gene reports a log2 fold change of 3.007 and an adjusted p-value of 0.04995. Which cellular component is this gene located in? | endosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10092","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in trans-Golgi Network Vesicle Bu... | |
medium_hidden_intermediate_10094 | A gene is connected to MAX via an 'interacts with' relationship and to 'protein binding' via an 'enables' relationship. Contextual evidence indicates that the protein product of this gene is specifically associated with c-Myc, N-Myc, and L-Myc proteins, but not with other bHLH, bZip, or bHLH-Zip proteins. Which protein... | Protein L-Myc | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10094","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is connected to MAX via an 'interacts with' relationship and to 'protein binding' via an 'enables' relationship. Cont... | |
medium_hidden_intermediate_10096 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the adenylate cyclase-activating G protein-coupled receptor signaling pathway. Evidence for this gene reports a log2 fold change of 4.939 and an adjusted p-value of 0.04609. Which disease is associated with this gene as a ... | rectal prolapse | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10096","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the adenylate cyclase-acti... | |
medium_hidden_intermediate_10099 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the response to acidic pH. Experimental evidence for this gene reports a log2 fold change of approximately 4.94 and an adjusted p-value of 0.046. Which protein is encoded by this gene? | G-protein coupled receptor 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10099","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the response to acidic pH.... | |
medium_hidden_intermediate_10100 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the positive regulation of cold-induced thermogenesis. Evidence for this gene reports a log2 fold change of 4.599 and an adjusted p-value of 0.04887. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10100","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the positive regulation of... | |
medium_hidden_intermediate_10101 | Enterovirus A is reported to downregulate a specific gene that participates in extracellular matrix organization. In a study of rhabdomyosarcoma cells (GSE103308), this gene exhibited a log2 fold change of approximately -1.82 and an adjusted p-value of approximately 0.026. Which disease is associated with this gene as ... | skin cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10101","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a specific gene that participates in extracellular matrix organization. In a study... | |
medium_hidden_intermediate_10103 | Two genes are upregulated by Vaccinia virus and associated with lymphoma. One of these genes exhibits a log2 fold change of approximately 6.30 and an adjusted p-value of approximately 5.64e-06 in cervical adenocarcinoma cell lines. Which protein is encoded by this specific gene? | Metallothionein-1E | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10103","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and associated with lymphoma. One of these genes exhibits a log2 fold change of ... | |
medium_hidden_intermediate_10104 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene, which is also enriched in conventional dendritic cells. This gene exhibited a log2 fold change of -1.082 and an adjusted p-value of 0.01358. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10104","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_10106 | In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which subsequently binds to VPS53. This gene exhibits a log2 fold change of -2.883 and an adjusted p-value of 0.002997. What molecular function is enabled by this gene? | GTPase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10106","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which subs... | |
medium_hidden_intermediate_10107 | Human alphaherpesvirus 3 is known to downregulate certain genes whose protein products are located in the endosome. In a study of melanoma cell lines (GSE136586), one such gene exhibited a log2 fold change of approximately -1.108 and an adjusted p-value of 2.462e-06. Which protein is encoded by this specific gene? | DCC-interacting protein 13-beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10107","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is known to downregulate certain genes whose protein products are located in the endosome. In a stu... | |
medium_hidden_intermediate_10108 | Zika virus downregulates a gene that is involved in the regulation of cilium assembly. Experimental data from glioma stem cells (study GSE114907) indicate that this specific gene has a log2 fold change of approximately -2.49 and an adjusted p-value of 0.0065. Which protein does this gene interact with? | RAB4A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10108","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the regulation of cilium assembly. Experimental data from glioma stem ce... | |
medium_hidden_intermediate_10109 | Hepacivirus C is reported to downregulate a specific gene, which is subsequently found to be enriched in Mucosa-associated invariant T (MAIT) cells. Experimental data for this gene in peripheral blood mononuclear cells indicates a log2 fold change of approximately -1.593 and an adjusted p-value of 0.002433. Which prote... | Copine-7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10109","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which is subsequently found to be enriched in Mucosa-associated i... | |
medium_hidden_intermediate_10110 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in mitochondrial RNA degradation. Evidence for this gene reports a log2 fold change of 1.434 and an adjusted p-value of 0.04759. Which protein is encoded by this gene? | SRA stem-loop-interacting RNA-binding protein, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10110","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in mitochondrial RNA degradation.... | |
medium_hidden_intermediate_10111 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific gene that interacts with HIST1H2BG. This gene exhibits a log2 fold change of approximately 3.03 and an adjusted p-value of 0.00023. What molecular function is enabled by this gene? | protein phosphatase regulator activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10111","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific gene that interacts with ... | |
medium_hidden_intermediate_10112 | Cardiovirus A upregulates a gene that participates in the Immune System. Evidence for one such gene reports a log2 fold change of 1.165 and an adjusted p-value of 0.03866. Which gene interacts with the gene identified by this evidence? | RAB11FIP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10112","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A upregulates a gene that participates in the Immune System. Evidence for one such gene reports a log2 fold chan... | |
medium_hidden_intermediate_10113 | Two genes are structurally linked to Enterovirus A via upregulation and to the RHOQ GTPase cycle via participation. One of these genes is reported in a study with a log2 fold change of approximately 1.774 and an adjusted p-value of 0.01075. Which cell type is this specific gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10113","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via upregulation and to the RHOQ GTPase cycle via participation. One of t... | |
medium_hidden_intermediate_10119 | In a study of Measles morbillivirus infection, multiple genes are upregulated by the virus and subsequently interact with the protein YWHAH. One such gene exhibits a log2 fold change of 1.848 and an adjusted p-value of 0.0009212. Which protein is encoded by this specific gene? | TBC1 domain family member 22B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10119","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, multiple genes are upregulated by the virus and subsequently interact with th... | |
medium_hidden_intermediate_10122 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to Conventional dendritic cell via an 'enriched in' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately -1.36 and an adjusted p-value of 0.0198. Which ... | CBY1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10122","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to Conventional d... | |
medium_hidden_intermediate_10123 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate multiple genes that are located in the mitochondrial intermembrane space. One such gene exhibited a log2 fold change of 3.775 and an adjusted p-value of 1.655e-06. What molecular function is enabled by this specific... | zinc ion binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10123","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate multiple genes that... | |
medium_hidden_intermediate_10124 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and associated with oxidoreductase activity showed a log2 fold change of 7.668 and an adjusted p-value of 2.612e-11. Which protein interacts with this specific gene product? | VCP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10124","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and associated with oxidor... | |
medium_hidden_intermediate_10125 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to the regulation of cell migration via an 'involved in' relationship. One of these genes has an associated log2 fold change of -2.562 and an adjusted p-value of 0.04309. Which cell type is ... | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10125","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_10126 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to Signaling by Interleukins via a 'participates in' relationship. One of these genes is associated with experimental data showing a log2 fold change of -3.972 and an adjusted p-value of 0.0... | Sphingosine 1-phosphate receptor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10126","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_10127 | Hepacivirus C upregulates a gene that is involved in the positive regulation of cytosolic calcium ion concentration. Evidence for one such gene reports a log2 fold change of 1.255 and an adjusted p-value of 0.0498. Which disease is associated with this gene as a biomarker? | benign neoplasm of stomach | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10127","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the positive regulation of cytosolic calcium ion concentration. Evidenc... | |
medium_hidden_intermediate_10130 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is downregulated and its product is located in the apical part of the cell. Evidence for this gene reports a log2 fold change of -1.055 and an adjusted p-value of 0.01225. Which protein is encoded by this gene? | Chloride intracellular channel protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10130","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is downregulat... | |
medium_hidden_intermediate_10131 | A gene is downregulated by Human betaherpesvirus 5 and is enriched in neutrophils. Evidence for this gene reports a log2 fold change of approximately -1.03 and an adjusted p-value of 0.0306. Which disease is associated with this gene as a biomarker? | pneumonia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10131","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human betaherpesvirus 5 and is enriched in neutrophils. Evidence for this gene reports a log2 fol... | |
medium_hidden_intermediate_10132 | Hepacivirus C is reported to upregulate a gene that is involved in the positive regulation of transcription by RNA polymerase II. Experimental data for one such gene shows a log2 fold change of 1.247 and an adjusted p-value of 0.01396. Which protein does this specific gene product bind to? | CD200R1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10132","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that is involved in the positive regulation of transcription by RNA polymeras... | |
medium_hidden_intermediate_10134 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to cytidine kinase activity via an 'enables' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 1.174 and an adjusted p-value of... | CDK1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10134","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_10135 | A gene is downregulated by Vaccinia virus and involved in signal transduction. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of -1.248 and an adjusted p-value of 0.03817. Which cell type is this gene enriched in? | gamma-delta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10135","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Vaccinia virus and involved in signal transduction. Experimental data for this gene in a cervical... | |
medium_hidden_intermediate_10136 | In a study of Measles morbillivirus infection, a specific gene is downregulated by the virus and participates in protein metabolism. Evidence for this gene reports a log2 fold change of approximately -1.100 and an adjusted p-value of 0.001081. Which protein is encoded by this gene? | Uridine diphosphate glucose pyrophosphatase NUDT14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10136","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is downregulated by the virus and participates in protein met... | |
medium_hidden_intermediate_10138 | Hepacivirus C is reported to downregulate a specific gene, which in turn participates in the response to elevated platelet cytosolic Ca2+. Experimental data for this gene shows a log2 fold change of -1.387 and an adjusted p-value of 0.01496. Which protein is encoded by this gene? | MICOS complex subunit MIC27 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10138","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which in turn participates in the response to elevated platelet c... | |
medium_hidden_intermediate_10140 | Zika virus downregulates a gene that interacts with NFIC. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.18 and an adjusted p-value of approximately 0.0084. Which protein is encoded by this gene? | Ataxin-1-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10140","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with NFIC. Experimental data for this gene in glioma stem cells (study GSE114... | |
medium_hidden_intermediate_10141 | Zika virus downregulates multiple genes that participate in DNA Double-Strand Break Repair. One such gene exhibits a log2 fold change of -2.223 and an adjusted p-value of 0.009656 in glioma stem cells. Which protein interacts with this specific gene product? | PCNA | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10141","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates multiple genes that participate in DNA Double-Strand Break Repair. One such gene exhibits a log2 fo... | |
medium_hidden_intermediate_10142 | Two genes are downregulated by Human immunodeficiency virus 1 and are associated with sarcoma. One of these genes exhibits a log2 fold change of approximately -1.33 and an adjusted p-value of 0.0169 in macrophages from study GSE108897. Which disease is linked to this specific gene through genomic alterations? | neuroferritinopathy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10142","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and are associated with sarcoma. One of these genes exhibits a... | |
medium_hidden_intermediate_10143 | Vaccinia virus downregulates a gene that participates in the Immune System. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this specific gene has a log2 fold change of -2.252 and an adjusted p-value of 0.003023. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10143","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene that participates in the Immune System. Experimental data from a cervical adenocarcinoma... | |
medium_hidden_intermediate_10145 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the inactivation of the APC/C via direct inhibition of the APC/C complex. Evidence for one such gene reports a log2 fold change of 1.046 and an adjusted p-value of 0.0004226. Which protein is encoded by that gene? | Anaphase-promoting complex subunit 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10145","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the inactivation of the APC/C ... | |
medium_hidden_intermediate_10146 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulation of the canonical Wnt signaling pathway. One of these genes exhibits a log2 fold change of -2.215 and an adjusted p-value of 0.04567 in lung tissue. Which disease is associated with genomic al... | Townes-Brocks syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10146","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regula... | |
medium_hidden_intermediate_10147 | Hepacivirus C is reported to upregulate a gene that is associated with melanoma. One such gene exhibits a log2 fold change of approximately 1.08 and an adjusted p-value of approximately 0.0207 in a specific study. Which protein is encoded by this gene? | CD5 antigen-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10147","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that is associated with melanoma. One such gene exhibits a log2 fold change o... | |
medium_hidden_intermediate_10148 | ALK interacts with a protein that enables protein binding. Evidence indicates that this protein interacts with the putative Rab33 GTPase-activating proteins TBC1D22A and TBC1D22B. Which protein is encoded by the gene corresponding to this interacting partner? | Golgi resident protein GCP60 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10148","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"ALK interacts with a protein that enables protein binding. Evidence indicates that this protein interacts with the putative ... | |
medium_hidden_intermediate_10149 | A gene serves as a marker for mitotic fetal germ cells and is enriched in intermediate monocytes. Evidence for one such gene reports a mean expression of 2.51 TPM, a z-score of 2.04, and a fold enrichment of 4.64. Which disease is associated with that specific gene? | B-cell chronic lymphocytic leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10149","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for mitotic fetal germ cells and is enriched in intermediate monocytes. Evidence for one such gene... | |
medium_hidden_intermediate_10150 | Human betaherpesvirus 5 upregulates a gene that participates in the Adaptive Immune System. Evidence for this gene reports a log2 fold change of 2.804 and an adjusted p-value of 0.007577. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10150","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in the Adaptive Immune System. Evidence for this gene reports a... | |
medium_hidden_intermediate_10151 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulation of GTPase activity. One of these genes exhibits a log2 fold change of approximately 2.16 and an adjusted p-value of approximately 0.0022 in lung tissue data. Which cell type is enriched for thi... | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10151","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulati... | |
medium_hidden_intermediate_10153 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and associated with adenoviridae infectious disease was found to have a log2 fold change of 1.981 and an adjusted p-value of 6.294e-06. Which disease is therapeutically linked to this specific gene? | substance withdrawal syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10153","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and associated with adenov... | |
medium_hidden_intermediate_10154 | In the study GSE157852, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for bipolar disorder. This specific gene exhibits a log2 fold change of 1.413 and an adjusted p-value of 0.01059 in choroid plexus epithelium. Which protein is encoded by this gene? | Dopamine receptor-interacting protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10154","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the study GSE157852, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a bioma... | |
medium_hidden_intermediate_10155 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with PARK2. This gene exhibited a log2 fold change of -1.083 and an adjusted p-value of 0.009005. Which protein is encoded by this gene? | Glycerol-3-phosphate dehydrogenase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10155","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_10157 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and serve as biomarkers for lung adenocarcinoma. One of these genes exhibits a log2 fold change of 1.322 and an adjusted p-value of 1.073e-05 in a specific study. Which biological process is this gene involved in? | I-kappaB phosphorylation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10157","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and serve as biomarkers for lung adenocar... | |
medium_hidden_intermediate_10158 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Keratan sulfate biosynthesis. One of these genes exhibits a log2 fold change of approximately 1.71 and an adjusted p-value of approximately 0.0115 in a specific study. What molecular function is enabled by this specifi... | N-acetyllactosaminide alpha-2,3-sialyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10158","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Keratan sulfate biosyn... | |
medium_hidden_intermediate_10159 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the membrane raft. Evidence for this gene reports a log2 fold change of -1.048 and an adjusted p-value of 1.234e-05. Which protein is encoded by this gene? | Erlin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10159","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the membrane raft. Evidence fo... | |
medium_hidden_intermediate_10161 | A gene is upregulated by Primate bocaparvovirus 1 and is involved in cell adhesion. Experimental data for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of 2.223 and an adjusted p-value of 0.03562. Which disease is associated with this gene? | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10161","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is involved in cell adhesion. Experimental data for this gene in a non... | |
medium_hidden_intermediate_10163 | A gene expressed in mitotic fetal germ cells and enabling sialyltransferase activity is the subject of evidence stating: 'In vitro enzyme analyses revealed that ST6GalNAc III and VI generated DSGG from MSGG with V(max)/K(m) values of 1.91 and 4.16 respectively.' Which disease is associated with the specific gene entity... | kidney cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10163","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene expressed in mitotic fetal germ cells and enabling sialyltransferase activity is the subject of evidence stating: 'In... | |
medium_hidden_intermediate_10164 | Two genes are structurally linked from Cardiovirus A via a downregulation relationship and subsequently to Non-classical monocyte via an enrichment relationship. One of these genes is associated with a log2 fold change of -2.121 and an adjusted p-value of 0.01663 in cervical adenocarcinoma cell lines. Which cellular co... | glutamatergic synapse | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10164","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Cardiovirus A via a downregulation relationship and subsequently to Non-classical mon... | |
medium_hidden_intermediate_10166 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that participates in the synthesis of phosphatidic acid. This specific gene exhibited a log2 fold change of -1.083 and an adjusted p-value of 0.009005. Which protein is encoded by this gene? | Glycerol-3-phosphate dehydrogenase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10166","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that participates in ... | |
medium_hidden_intermediate_10169 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn encodes a protein that binds to SEC24D. The upregulation of this gene was characterized by a log2 fold change of approximately 2.29 and an adjusted p-value of approximately 2.76e-... | Protein transport protein Sec24A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10169","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_10170 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to prostate carcinoma via genomic alterations. One of these genes is associated with a study reporting a log2 fold change of approximately -1.125 and an adjusted p-value of 0.02737. Which cell type is enric... | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10170","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to prostat... | |
medium_hidden_intermediate_10171 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A upregulates a specific gene, which in turn interacts with YWHAZ. This gene exhibits a log2 fold change of approximately 1.36 and an adjusted p-value of 0.02012. Which protein is encoded by this gene? | Phosphatidylinositide 4-phosphatase SAC2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10171","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A upregulates a specific gene, which in turn interacts with YW... | |
medium_hidden_intermediate_10172 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which in turn participates in Signaling by TGFB family members. This gene exhibited a log2 fold change of approximately 1.54 and an adjusted p-value of 0.0069. Which protein is encoded by this gene? | Protein TMEPAI | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10172","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which in ... | |
medium_hidden_intermediate_10174 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in a disease process. Experimental data for this gene, derived from peripheral blood mononuclear cells in study GSE131504, indicates a log2 fold change of approximately -2.07 and an adjusted p-value of approximately 0.0084. Which diseas... | bipolar disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10174","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in a disease process. Experimental data ... | |
medium_hidden_intermediate_10175 | Two genes are upregulated by Vaccinia virus and interact with STAU1. One of these genes shows a log2 fold change of 2.018 and an adjusted p-value of 1.852e-05 in cervical adenocarcinoma cell lines. Which cell type is enriched for the gene matching these expression statistics? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10175","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and interact with STAU1. One of these genes shows a log2 fold change of 2.018 an... | |
medium_hidden_intermediate_10176 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to urinary bladder neoplasm via a biomarker relationship. One of these genes is associated with a log2 fold change of approximately -1.06 and an adjusted p-value of 0.0072. Which protein is e... | Transcriptional enhancer factor TEF-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10176","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship... | |
medium_hidden_intermediate_10179 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that participates in the CDC42 GTPase cycle. This specific gene exhibited a log2 fold change of approximately -1.194 and an adjusted p-value of 0.0001877. What molecular function is enabled by this gene? | guanyl-nucleotide exchange factor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10179","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that participates in ... | |
medium_hidden_intermediate_10180 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the negative regulation of cell population proliferation. One of these genes exhibits a log2 fold change of approximately -1.35 and an adjusted p-value of approximately 0.038 in alveolar type II cells. Which cellula... | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10180","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the negative regula... | |
medium_hidden_intermediate_10182 | Vaccinia virus upregulates a gene that participates in SLC-mediated transmembrane transport. Evidence for this gene in a cervical adenocarcinoma cell line reports a log2 fold change of approximately 5.18 and an adjusted p-value of approximately 1.83e-06. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10182","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that participates in SLC-mediated transmembrane transport. Evidence for this gene in a cer... | |
medium_hidden_intermediate_10183 | Hepacivirus C is reported to downregulate multiple genes that participate in the 'Signaling by Rho GTPases, Miro GTPases and RHOBTB3' pathway. One such gene exhibits a log2 fold change of -1.488 and an adjusted p-value of 0.01729 in peripheral blood mononuclear cells. Which protein does this specific gene product bind ... | RHOQ | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10183","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate multiple genes that participate in the 'Signaling by Rho GTPases, Miro GTPases and... | |
medium_hidden_intermediate_10185 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which in turn interacts with UBC. This gene exhibited a log2 fold change of 3.209 and an adjusted p-value of 0.01162. Which protein is encoded by this gene? | Ubiquitin carboxyl-terminal hydrolase 50 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10185","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_10186 | Zika virus downregulates a specific gene that subsequently binds to UBB. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.093 and an adjusted p-value of 0.03949. Which disease is associated with this gene? | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10186","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that subsequently binds to UBB. Experimental data for this gene in glioma stem cell... | |
medium_hidden_intermediate_10188 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and participates in Programmed Cell Death. This specific gene exhibits a log2 fold change of approximately 1.713 and an adjusted p-value of 1.085e-05. Which protein is encoded by this gene? | Cell death regulator Aven | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10188","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and participates in Pro... | |
medium_hidden_intermediate_10190 | In a study of glioma stem cells (GSE114907), Zika virus downregulates a gene that enables cysteine-type endopeptidase activity. One such gene exhibits a log2 fold change of approximately -1.19 and an adjusted p-value of 0.0488. Which biological process is this specific gene involved in? | proteolysis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10190","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus downregulates a gene that enables cysteine-type endopeptidase activi... | |
medium_hidden_intermediate_10194 | Human immunodeficiency virus 1 is reported to downregulate a specific gene, which is in turn associated with intraepithelial neoplasia. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.087 and an adjusted p-value of 0.0047. Which protein is encoded by this gene? | Osteoclast-stimulating factor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10194","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 is reported to downregulate a specific gene, which is in turn associated with intraepithelial... | |
medium_hidden_intermediate_10196 | Hepacivirus C upregulates a gene that participates in protein localization. In a study of hepatocytes (GSE132606), one such gene showed a log2 fold change of approximately 1.027 and an adjusted p-value of 0.002016. Which protein does this specific gene interact with? | CUL3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10196","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in protein localization. In a study of hepatocytes (GSE132606), one such ... | |
medium_hidden_intermediate_10197 | Human polyomavirus 1 is reported to upregulate a gene that is enriched in neutrophils. In a specific study (GSE135833) involving renal epithelial cells, one such gene showed a log2 fold change of 1.503 and an adjusted p-value of 0.02755. Which protein is encoded by this gene? | Kelch repeat and BTB domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10197","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 is reported to upregulate a gene that is enriched in neutrophils. In a specific study (GSE135833) invol... | |
medium_hidden_intermediate_10199 | Pegivirus C is reported to downregulate a gene that is associated with pancreatic adenocarcinoma. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibits a log2 fold change of -1.288 and an adjusted p-value of 0.008611. Which protein is encoded by this specific gene? | Solute carrier organic anion transporter family member 3A1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10199","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is associated with pancreatic adenocarcinoma. In a study of peripheral b... |
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