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medium_hidden_intermediate_09899 | In a study of lung cells, a gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the cholesterol biosynthetic process. This gene exhibits a log2 fold change of approximately -1.074 and an adjusted p-value of 0.0001135. Which protein is encoded by this gene? | Delta(14)-sterol reductase TM7SF2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09899","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells, a gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved i... | |
medium_hidden_intermediate_09900 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the negative regulation of the ERK1 and ERK2 cascade. One of these genes exhibits a log2 fold change of 1.466 and an adjusted p-value of 6.958e-07 in a specific study. Which disease is associated with genomic alterati... | lung neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09900","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the negative regulati... | |
medium_hidden_intermediate_09901 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables nucleoside diphosphate kinase activity. In a specific study, this gene exhibited a log2 fold change of approximately -1.128 and an adjusted p-value of 0.0005438. Which protein is encoded by this gene? | Nucleoside diphosphate kinase C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09901","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables nucleoside diphosphate kinase activi... | |
medium_hidden_intermediate_09902 | Two distinct drugs are structurally linked to both Estradiol and Fostamatinib via interaction relationships. One of these drugs is distinguished by evidence indicating that Letrozole results in higher testosterone and lower estradiol levels compared to it. Which disease is indicated for this specific drug? | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09902","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs are structurally linked to both Estradiol and Fostamatinib via interaction relationships. One of these dr... | |
medium_hidden_intermediate_09903 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with BTRC. Evidence for one such gene reports a log2 fold change of 1.580 and an adjusted p-value of 0.01902. Which protein is encoded by that gene? | Lysophosphatidylcholine acyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09903","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with BTRC. Evidence for one such gen... | |
medium_hidden_intermediate_09904 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in Membrane Trafficking. One of these genes shows a log2 fold change of 1.525 and an adjusted p-value of 0.0244 in a specific study. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09904","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in Membrane Trafficking. One of these genes show... | |
medium_hidden_intermediate_09905 | Hepacivirus C upregulates a gene that interacts with ANLN. One such gene exhibits a log2 fold change of approximately 1.003 and an adjusted p-value of 0.004259 in peripheral blood mononuclear cells. What molecular function is enabled by this gene? | RNA binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09905","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that interacts with ANLN. One such gene exhibits a log2 fold change of approximately 1.003 ... | |
medium_hidden_intermediate_09906 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with STX7. One such gene exhibits a log2 fold change of approximately 1.022 and an adjusted p-value of 6.449e-07. Which protein is encoded by this gene? | GTPase NRas | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09906","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with STX7. One such gene exhibits a ... | |
medium_hidden_intermediate_09907 | Zika virus downregulates a gene that participates in MAPK1/MAPK3 signaling. Evidence for this gene reports a log2 fold change of -1.121 and an adjusted p-value of 0.02419. Which protein is encoded by this gene? | Alpha/beta hydrolase domain-containing protein 17C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09907","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in MAPK1/MAPK3 signaling. Evidence for this gene reports a log2 fold chang... | |
medium_hidden_intermediate_09909 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in glycerol transmembrane transport. Evidence for this specific gene reports a log2 fold change of 1.065 and an adjusted p-value of 0.009649. Which protein is encoded by this gene? | Aquaporin-11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09909","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in glycerol transmembrane transpor... | |
medium_hidden_intermediate_09911 | A gene is downregulated by Primate bocaparvovirus 1 and participates in cellular responses to stimuli. Experimental evidence for this gene reports a log2 fold change of -1.963 and an adjusted p-value of 0.03983. Which disease is associated with this gene? | hereditary multiple osteochondromas | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09911","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in cellular responses to stimuli. Experimental evidence... | |
medium_hidden_intermediate_09912 | Two genes are known to be upregulated by Vaccinia virus and to bind SKP1. One of these genes exhibits a log2 fold change of 2.939 and an adjusted p-value of 9.025e-11 in a specific study. Which cell type is this gene enriched in? | conventional dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09912","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are known to be upregulated by Vaccinia virus and to bind SKP1. One of these genes exhibits a log2 fold change of ... | |
medium_hidden_intermediate_09914 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus and participates in the CHD6, CHD7, CHD8, CHD9 subfamily. This gene exhibits a log2 fold change of approximately 1.99 and an adjusted p-value of 0.001746. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09914","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus a... | |
medium_hidden_intermediate_09915 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection upregulates a specific gene that subsequently interacts with the Androgen Receptor (AR). This gene exhibits a log2 fold change of approximately 1.33 and an adjusted p-value of approximately 0.00013. Which biological process is this gene in... | regulation of myoblast proliferation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09915","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection upregulates a specific gene that subsequent... | |
medium_hidden_intermediate_09920 | Two genes are upregulated by Vaccinia virus and participate in G alpha (s) signalling events. One of these genes exhibits a log2 fold change of approximately 3.285 and an adjusted p-value of 0.0002373 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene as a biomarker? | psoriasis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09920","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in G alpha (s) signalling events. One of these genes exhibits a ... | |
medium_hidden_intermediate_09922 | Vaccinia virus upregulates a gene that participates in the Cell Cycle. Evidence for this gene reports a log2 fold change of 4.505 and an adjusted p-value of 5.423e-08. In which cell type is this gene enriched? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09922","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that participates in the Cell Cycle. Evidence for this gene reports a log2 fold change of ... | |
medium_hidden_intermediate_09924 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes, which in turn interact with the protein YWHAB. One such intermediate gene exhibits a log2 fold change of approximately 1.36 and an adjusted p-value of 0.02012. Which protein is encoded by this specific ... | Phosphatidylinositide 4-phosphatase SAC2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09924","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes, which ... | |
medium_hidden_intermediate_09925 | Zika virus downregulates a specific gene that participates in MAPK family signaling cascades. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.606 and an adjusted p-value of 0.01865. Which biological process is this gene involved in? | signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09925","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in MAPK family signaling cascades. In a study of glioma stem cell... | |
medium_hidden_intermediate_09926 | Zika virus downregulates a specific gene that enables transcription corepressor activity. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.425 and an adjusted p-value of 0.03648. Which disease is associated with this gene? | gastric carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09926","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that enables transcription corepressor activity. In a study of glioma stem cells (G... | |
medium_hidden_intermediate_09927 | In a study of glioma stem cells (GSE114907), a gene is downregulated by Zika virus and binds to RPA2. This specific gene exhibits a log2 fold change of approximately -3.04 and an adjusted p-value of 0.0209. Which disease is associated with this gene? | cervical squamous cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09927","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), a gene is downregulated by Zika virus and binds to RPA2. This specific gene exh... | |
medium_hidden_intermediate_09928 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and participates in Signaling by TGFB family members. This specific gene exhibits a log2 fold change of approximately -3.24 and an adjusted p-value of 0.045. Which protein is encoded by this gene? | Cingulin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09928","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and part... | |
medium_hidden_intermediate_09930 | Two genes are upregulated by Influenza A virus and enriched in non-classical monocytes. One of these genes exhibits a log2 fold change of approximately 1.11 and an adjusted p-value of approximately 0.000343 in bronchial epithelial cells. Which protein interacts with this specific gene? | CAMLG | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09930","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Influenza A virus and enriched in non-classical monocytes. One of these genes exhibits a log2 f... | |
medium_hidden_intermediate_09931 | In a study of glioblastoma multiforme cancer stem cells (GSE102924), Zika virus infection leads to the upregulation of certain genes involved in the cellular response to heat. One such gene exhibits a log2 fold change of approximately 1.51 and an adjusted p-value of 0.0086. Which protein is encoded by this specific gen... | AN1-type zinc finger protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09931","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioblastoma multiforme cancer stem cells (GSE102924), Zika virus infection leads to the upregulation of certa... | |
medium_hidden_intermediate_09933 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the lysosomal membrane. Evidence for one such gene reports a log2 fold change of 1.021 and an adjusted p-value of 0.008438. Which protein is encoded by that gene? | Integral membrane protein GPR137 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09933","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the lysosomal membrane. Evidence... | |
medium_hidden_intermediate_09935 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with RPL7A. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) show a log2 fold change of -1.338 and an adjusted p-value of 0.005425. Which protein is encoded by this gene? | RNA exonuclease 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09935","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with RPL7A. Experimental data for this inte... | |
medium_hidden_intermediate_09936 | Measles morbillivirus upregulates a gene that subsequently interacts with STAT3. Experimental data for one such gene reports a log2 fold change of approximately 1.42 and an adjusted p-value of approximately 0.000236. Which biological process is this gene involved in? | negative regulation of canonical NF-kappaB signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09936","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that subsequently interacts with STAT3. Experimental data for one such gene reports... | |
medium_hidden_intermediate_09938 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to acute lymphoblastic leukemia via an association relationship. One of these genes has a reported log2 fold change of 1.320 and an adjusted p-value of 0.002683. Which protein is encoded by this specific g... | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09938","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to acute ... | |
medium_hidden_intermediate_09939 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is located in the late endosome membrane. Evidence for this gene reports a log2 fold change of approximately -1.34 and an adjusted p-value of approximately 0.0023. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09939","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is located in the late endosome membran... | |
medium_hidden_intermediate_09940 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Extracellular matrix organization. Evidence for this gene reports a log2 fold change of approximately 1.08 and an adjusted p-value of 0.0055. Which disease is associated with this gene? | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09940","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Extracellular matrix orga... | |
medium_hidden_intermediate_09941 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the maturation of DENV proteins. Experimental data for this gene reports a log2 fold change of -1.035 and an adjusted p-value of 0.01708. Which biological process is this gene involved in? | protein maturation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09941","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the maturation of DENV ... | |
medium_hidden_intermediate_09943 | GNA15 interacts with a specific G protein-coupled receptor that is involved in protein binding. Research investigating the effect of zinc on G protein-coupled receptor association processes utilized FRET and co-immunopurification studies with this receptor alongside 5-HT1A and GalR1, which are known to dimerize. Which ... | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09943","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"GNA15 interacts with a specific G protein-coupled receptor that is involved in protein binding. Research investigating the e... | |
medium_hidden_intermediate_09945 | Two genes are structurally linked to DDB1 via an interaction and are both involved in the regulation of G protein-coupled receptor signaling pathways. One of these genes encodes a protein for which Rhodopsin, the beta 2-adrenergic receptor, and the m2 muscarinic cholinergic receptor serve as stimulus-dependent substrat... | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09945","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to DDB1 via an interaction and are both involved in the regulation of G protein-coupled re... | |
medium_hidden_intermediate_09947 | Hepacivirus C downregulates a gene that participates in Sphingolipid metabolism. Evidence for one such gene reports a log2 fold change of -1.061 and an adjusted p-value of 2.629e-07. Which molecular function is enabled by that gene? | sphingosine-1-phosphate phosphatase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09947","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that participates in Sphingolipid metabolism. Evidence for one such gene reports a log2 f... | |
medium_hidden_intermediate_09948 | Pegivirus C is reported to downregulate a gene that subsequently binds to SNRPD3. In a study of peripheral blood mononuclear cells (GSE131504), one such intermediate gene exhibited a log2 fold change of -2.040 and an adjusted p-value of 0.001697. Which protein is encoded by this specific gene? | RNA-binding region-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09948","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that subsequently binds to SNRPD3. In a study of peripheral blood mononuclear... | |
medium_hidden_intermediate_09951 | Human betaherpesvirus 5 is linked to atherosclerosis via a gene that it downregulates and which is associated with the disease. One such gene exhibits a log2 fold change of approximately -1.03 and an adjusted p-value of 0.02072 in foreskin fibroblast cell lines. Which disease is connected to this specific gene through ... | congestive heart failure | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09951","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is linked to atherosclerosis via a gene that it downregulates and which is associated with the disea... | |
medium_hidden_intermediate_09952 | Zika virus downregulates a specific gene, which is enriched in naive CD4+ T cells. Transcriptomic data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of -2.365 and an adjusted p-value of 0.01608. Which protein is encoded by this gene? | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09952","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which is enriched in naive CD4+ T cells. Transcriptomic data from glioma stem cell... | |
medium_hidden_intermediate_09953 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of a gene involved in the collagen biosynthetic process. One such gene exhibits a log2 fold change of -2.315 and an adjusted p-value of 0.006825. Which protein is encoded by this specific gene? | Reticulocalbin-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09953","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of a gene involved in ... | |
medium_hidden_intermediate_09954 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the negative regulation of cell migration. One of these genes exhibits a log2 fold change of -3.485 and an adjusted p-value of 0.0189 in a specific study. Which disease is associated with this gene as a biomarker? | Crohn disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09954","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the negative regula... | |
medium_hidden_intermediate_09955 | Vaccinia virus downregulates a gene that is enriched in non-classical monocytes. Evidence for one such gene reports a log2 fold change of -3.039 and an adjusted p-value of 0.003593. Which protein is encoded by that gene? | SEC14 domain and spectrin repeat-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09955","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene that is enriched in non-classical monocytes. Evidence for one such gene reports a log2 f... | |
medium_hidden_intermediate_09956 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn participates in the RHOJ GTPase cycle. Evidence for this gene shows a log2 fold change of approximately -1.18 and an adjusted p-value of 0.027. Which protein is encoded by ... | Copine-8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09956","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_09958 | A gene serves as a marker for germ cells and is enriched in naive B cells. Evidence for this gene includes a mean expression of 10.23 TPM, a z-score of 3.07, and a fold enrichment of 23.20. Which disease is associated with this gene as a biomarker? | Burkitt lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09958","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for germ cells and is enriched in naive B cells. Evidence for this gene includes a mean expression... | |
medium_hidden_intermediate_09959 | Zika virus downregulates a specific gene, which in turn interacts with HSP90AA1. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -2.09 and an adjusted p-value of 0.0041. Which disease is associated with this gene? | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09959","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with HSP90AA1. Experimental data for this gene in glioma s... | |
medium_hidden_intermediate_09960 | Zika virus infection leads to the downregulation of specific genes that are involved in the positive regulation of muscle contraction. One such gene exhibits a log2 fold change of -2.731 and an adjusted p-value of 0.02829 in glioma stem cells. Which protein is encoded by this gene? | Voltage-dependent L-type calcium channel subunit beta-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09960","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of specific genes that are involved in the positive regulation of muscle co... | |
medium_hidden_intermediate_09961 | A gene is downregulated by Hepacivirus C and associated with neuroblastoma. Experimental data for this gene reports a log2 fold change of -1.796 and an adjusted p-value of 0.02096. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09961","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Hepacivirus C and associated with neuroblastoma. Experimental data for this gene reports a log2 f... | |
medium_hidden_intermediate_09962 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to gastric cancer via association. One of these genes exhibits a log2 fold change of 1.302 and an adjusted p-value of 0.00311 in lung cells. Which protein is encoded by this specific gene? | RNA binding motif protein, X-linked-like-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09962","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to gastric cancer via ass... | |
medium_hidden_intermediate_09963 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with CUL3. This gene exhibited a log2 fold change of approximately 1.535 and an adjusted p-value of 2.451e-08. Which protein is encoded by this gene? | PCI domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09963","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_09964 | Two distinct therapeutic agents are structurally linked to both Etanercept and Samarium (153Sm) lexidronam via interaction relationships. One of these agents is identified in clinical evidence as an anti-CD52 antibody, which has been associated with immunosuppression when used alone or in combination with anti-TNF-α tr... | B-cell chronic lymphocytic leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09964","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct therapeutic agents are structurally linked to both Etanercept and Samarium (153Sm) lexidronam via interaction r... | |
medium_hidden_intermediate_09965 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with ISG15. Experimental data for this gene reports a log2 fold change of 1.329 and an adjusted p-value of 0.00602. Which biological process is this gene involved in? | protein deubiquitination | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09965","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with ISG15. Experimental data f... | |
medium_hidden_intermediate_09966 | Dengue virus infection leads to the downregulation of certain genes involved in the regulation of endocytosis. In a study using a hepatoma cell line (GSE110512), one such gene was found to have a log2 fold change of approximately -1.448 and an adjusted p-value of 0.009605. Which protein is encoded by this specific gene... | Sorting nexin-12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09966","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Dengue virus infection leads to the downregulation of certain genes involved in the regulation of endocytosis. In a study us... | |
medium_hidden_intermediate_09967 | Zika virus downregulates a gene that interacts with RAB9A. In glioma stem cells, one such gene exhibits a log2 fold change of -3.174 and an adjusted p-value of 0.002827. Which protein is encoded by this gene? | DEP domain-containing protein 1B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09967","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with RAB9A. In glioma stem cells, one such gene exhibits a log2 fold change o... | |
medium_hidden_intermediate_09968 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and involved in cell differentiation. This specific gene exhibits a log2 fold change of approximately -1.136 and an adjusted p-value of 0.007452. Which protein is encoded by this gene? | Glutaredoxin-2, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09968","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and invo... | |
medium_hidden_intermediate_09969 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that enables zinc ion binding. This gene exhibited a log2 fold change of 2.368 and an adjusted p-value of 1.233e-09. Which protein is encoded by this gene? | Protein farnesyltransferase subunit beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09969","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_09970 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to RIC1. This gene exhibits a log2 fold change of approximately 1.602 and an adjusted p-value of 0.002356. Which protein is encoded by this gene? | ADP-ribosylation factor-related protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09970","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to RIC1. This... | |
medium_hidden_intermediate_09971 | Cardiovirus A is reported to downregulate a gene that is involved in the negative regulation of transcription by RNA polymerase II. Experimental data from a study on cervical adenocarcinoma cell lines (GSE122967) indicates that this specific gene has a log2 fold change of approximately -1.059 and an adjusted p-value of... | Zinc finger protein AEBP2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09971","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A is reported to downregulate a gene that is involved in the negative regulation of transcription by RNA polymer... | |
medium_hidden_intermediate_09973 | Human alphaherpesvirus 1 downregulates a gene that participates in the degradation of the extracellular matrix. Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that one such gene has a log2 fold change of -1.620 and an adjusted p-value of 0.003829. Which protein is encoded by this spec... | A disintegrin and metalloproteinase with thrombospondin motifs 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09973","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 downregulates a gene that participates in the degradation of the extracellular matrix. Experimental... | |
medium_hidden_intermediate_09974 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the CHD3, CHD4, CHD5 subfamily. Evidence for this gene reports a log2 fold change of 1.204 and an adjusted p-value of 0.00602. Which biological process is this gene involved in? | chromatin remodeling | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09974","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the CHD3, CHD4, CHD5 subf... | |
medium_hidden_intermediate_09976 | A pharynx neoplasm is localized to a structure that has a developmental contribution from the neural crest. Evidence concerning one such entity describes it as a subdivision of the skeleton which includes the upper and lower jaw skeletons. Which anatomy is connected to that entity through the 'part of' relationship? | facial skeleton | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09976","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A pharynx neoplasm is localized to a structure that has a developmental contribution from the neural crest. Evidence concern... | |
medium_hidden_intermediate_09978 | Zika virus downregulates a gene that participates in sphingolipid metabolism. Evidence for this gene reports a log2 fold change of -1.893 and an adjusted p-value of 0.01554. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09978","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in sphingolipid metabolism. Evidence for this gene reports a log2 fold cha... | |
medium_hidden_intermediate_09982 | Pegivirus C downregulates a specific gene, which in turn interacts with CCNF. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) reports a log2 fold change of approximately -1.145 and an adjusted p-value of 0.006552. Which protein is encoded by this gene? | LanC-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09982","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene, which in turn interacts with CCNF. Experimental data for this intermediate gene i... | |
medium_hidden_intermediate_09983 | Vaccinia virus infection leads to the upregulation of specific genes that participate in cellular responses to stimuli. In a study of cervical adenocarcinoma cell lines (GSE11238), one such upregulated gene exhibited a log2 fold change of approximately 4.16 and an adjusted p-value of 1.603e-10. Which protein is encoded... | Isocitrate dehydrogenase [NADP] cytoplasmic | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09983","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus infection leads to the upregulation of specific genes that participate in cellular responses to stimuli. In a... | |
medium_hidden_intermediate_09984 | Human alphaherpesvirus 1 downregulates a gene that is located in the membrane. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately -1.014 and an adjusted p-value of approximately 0.00256. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09984","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 downregulates a gene that is located in the membrane. Evidence for this gene in a monocytic leukemi... | |
medium_hidden_intermediate_09985 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of certain genes that subsequently bind to SRSF4. One such gene exhibits a log2 fold change of 1.712 and an adjusted p-value of 3.054e-10. Which protein is encoded by this specific gene? | U6 snRNA-associated Sm-like protein LSm5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09985","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of certain g... | |
medium_hidden_intermediate_09987 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate a specific gene that is involved in brain development. This gene exhibited a log2 fold change of approximately 1.086 and an adjusted p-value of 1.232e-05. Which disease is associated with this ge... | pontocerebellar hypoplasia, type 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09987","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate... | |
medium_hidden_intermediate_09989 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn participates in Cytokine Signaling in the Immune system. This gene exhibited a log2 fold change of approximately 1.607 and an adjusted p-value of 2.731e-06. Which protein is encod... | BolA-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09989","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_09990 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of specific genes that are involved in the positive regulation of the apoptotic process. One such gene exhibits a log2 fold change of -2.242 and an adjusted p-value of 0.001621. Which gene interacts with this specific ... | RPS6KA3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09990","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of specific genes that... | |
medium_hidden_intermediate_09991 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in transcriptional regulation by RUNX1. Evidence for this gene reports a log2 fold change of 1.063 and an adjusted p-value of 0.025. Which protein is encoded by this gene? | Suppressor of cytokine signaling 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09991","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in transcriptional regulation by ... | |
medium_hidden_intermediate_09992 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the response to endoplasmic reticulum stress. Experimental data for this gene reports a log2 fold change of approximately 1.119 and an adjusted p-value of 0.02061. Which protein is encoded by this gene? | Secretory carrier-associated membrane protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09992","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the response to endoplasmi... | |
medium_hidden_intermediate_09993 | A gene serves as a marker for retinoid acid signaling-responsive fetal germ cells and is enriched in non-classical monocytes. Expression data for this gene in immune cells indicates a mean expression of 92.14 TPM, a z-score of 2.02, and a fold enrichment of 2.25. Which disease is associated with this gene as a biomarke... | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09993","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for retinoid acid signaling-responsive fetal germ cells and is enriched in non-classical monocytes... | |
medium_hidden_intermediate_09996 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the early endosome. One of these genes shows a log2 fold change of 1.192 and an adjusted p-value of 3.218e-05 in a specific study. Which disease is associated with this gene as a biomarker? | squamous cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09996","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the early endosome. On... | |
medium_hidden_intermediate_09997 | Two genes are downregulated by Vaccinia virus and are involved in the negative regulation of transcription by RNA polymerase II. One of these genes exhibits a log2 fold change of -1.805 and an adjusted p-value of 0.01301 in a cervical adenocarcinoma cell line study. Which disease is associated with this specific gene? | urinary bladder carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09997","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Vaccinia virus and are involved in the negative regulation of transcription by RNA polymerase... | |
medium_hidden_intermediate_09999 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables G protein activity. One such gene exhibits a log2 fold change of 4.468 and an adjusted p-value of 0.02236. Which protein is encoded by this specific gene? | Ras-related protein Rab-7b | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_09999","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables G protein activity. On... | |
medium_hidden_intermediate_10001 | Two genes are upregulated by Vaccinia virus and participate in axon guidance. One of these genes shows a log2 fold change of 1.358 and an adjusted p-value of 8e-10 in a specific study. Which disease is associated with this gene? | colon carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10001","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in axon guidance. One of these genes shows a log2 fold change of... | |
medium_hidden_intermediate_10002 | Pegivirus C downregulates a gene that participates in Intra-Golgi and retrograde Golgi-to-ER traffic. Evidence for this gene in peripheral blood mononuclear cells (study GSE131504) reports a log2 fold change of -2.167 and an adjusted p-value of 0.01214. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10002","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in Intra-Golgi and retrograde Golgi-to-ER traffic. Evidence for this gene... | |
medium_hidden_intermediate_10004 | A gene is upregulated by Human immunodeficiency virus 1 and participates in protein localization. Evidence for this gene in macrophages from study GSE108897 reports a log2 fold change of 1.821 and an adjusted p-value of 0.01083. Which disease is associated with this gene as a biomarker? | hypertensive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10004","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and participates in protein localization. Evidence for this gene in ... | |
medium_hidden_intermediate_10006 | Two genes are linked to Human immunodeficiency virus 1 via a downregulation relationship and to acute myeloid leukemia via a biomarker relationship. One of these genes exhibits a log2 fold change of -1.818 and an adjusted p-value of 0.01388 in macrophages (study GSE108897). Which protein is encoded by this specific gen... | STEAP1 protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10006","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Human immunodeficiency virus 1 via a downregulation relationship and to acute myeloid leukemia via a... | |
medium_hidden_intermediate_10007 | Two distinct cell types are linked to the process of T cell-mediated cytotoxicity via the 'enabled by cell' relationship and both express ZNF395 as a marker. One of these cell types is described in the evidence as 'A CD4-positive, alpha-beta T cell that has cytotoxic function.' Which cell type corresponds to this descr... | activated CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10007","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct cell types are linked to the process of T cell-mediated cytotoxicity via the 'enabled by cell' relationship and... | |
medium_hidden_intermediate_10008 | Hepacivirus C is linked to Class A/1 (Rhodopsin-like receptors) via a gene that is downregulated by the virus and participates in the receptor class. One such gene exhibits a log2 fold change of -1.310 and an adjusted p-value of 5.701e-06. Which disease is associated with this gene through genomic alterations? | mesothelioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10008","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is linked to Class A/1 (Rhodopsin-like receptors) via a gene that is downregulated by the virus and participat... | |
medium_hidden_intermediate_10009 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene was found to be downregulated by the virus and associated with disease. This gene exhibited a log2 fold change of -1.302 and an adjusted p-value of 0.019. Which protein is encoded by this gene? | Carbonic anhydrase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10009","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene wa... | |
medium_hidden_intermediate_10010 | Identify the gene that is expressed in monocytes and enables GTPase activity, specifically the one for which evidence indicates its protein product is a functional GTPase with activity comparable to MxA. Which disease is associated with this gene? | acute myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10010","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Identify the gene that is expressed in monocytes and enables GTPase activity, specifically the one for which evidence indica... | |
medium_hidden_intermediate_10011 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in fatty acid metabolism. In a study using foreskin fibroblast cell lines, one such gene exhibited a log2 fold change of approximately -1.47 and an adjusted p-value of 0.047. Which cellular component is this specific gene located in? | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10011","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in fatty acid metabolism. In a study using fore... | |
medium_hidden_intermediate_10012 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to pancreatic neoplasm via an association relationship. One of these genes was reported in a study (GSE164073) involving corneal epithelium, showing a log2 fold change of approximately 4.84 and an adjusted... | Transmembrane 4 L6 family member 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10012","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to pancre... | |
medium_hidden_intermediate_10013 | Two genes are upregulated by Enterovirus A and enriched in intermediate monocytes. One of these genes exhibits a log2 fold change of approximately 4.12 and an adjusted p-value of 0.0088 in rhabdomyosarcoma cells. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10013","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Enterovirus A and enriched in intermediate monocytes. One of these genes exhibits a log2 fold c... | |
medium_hidden_intermediate_10014 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in TCF dependent signaling in response to WNT. Evidence for one such gene reports a log2 fold change of 1.232 and an adjusted p-value of 0.0009031. Which protein is encoded by that gene? | GSK-3-binding protein FRAT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10014","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in TCF dependent signaling in res... | |
medium_hidden_intermediate_10015 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables integrin binding. Evidence for this gene reports a log2 fold change of 1.931 and an adjusted p-value of 0.04559. Which disease is associated with this gene? | lung adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10015","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables integrin binding. Evidence for th... | |
medium_hidden_intermediate_10016 | RRAGB interacts with multiple partners that subsequently interact with YWHAB. One such intermediate protein is described in evidence stating: 'Rag A was associated with both Rag C and Rag D in their C-terminal regions where a potential leucine zipper motif and a coiled-coil structure were found.' Which protein is encod... | Ras-related GTP-binding protein C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10016","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"RRAGB interacts with multiple partners that subsequently interact with YWHAB. One such intermediate protein is described in ... | |
medium_hidden_intermediate_10017 | Two genes are downregulated by Human betaherpesvirus 5 and are associated with benign prostatic hyperplasia. One of these genes exhibits a log2 fold change of -1.536 and an adjusted p-value of 0.005559 in foreskin fibroblast cell lines. Which disease is linked to this specific gene as a biomarker? | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10017","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human betaherpesvirus 5 and are associated with benign prostatic hyperplasia. One of these ge... | |
medium_hidden_intermediate_10020 | A gene is upregulated by Measles morbillivirus and participates in Transmission across Chemical Synapses. Experimental data for this gene reports a log2 fold change of 2.463 and an adjusted p-value of 0.001816. Which disease is associated with this gene as a biomarker? | substance dependence | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10020","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and participates in Transmission across Chemical Synapses. Experimental data ... | |
medium_hidden_intermediate_10023 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and subsequently bind to RXRA. One of these genes exhibits a log2 fold change of 1.581 and an adjusted p-value of 0.006733 in a specific study. Which protein is encoded by the gene matching these statistical values? | Retinoic acid receptor alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10023","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and subsequently bind to RXRA. One of the... | |
medium_hidden_intermediate_10024 | Hepacivirus C upregulates a gene that participates in the synthesis of UDP-N-acetyl-glucosamine. Experimental data for one such gene reports a log2 fold change of approximately 2.12 and an adjusted p-value of approximately 2.07e-05. Which protein is encoded by this gene? | N-acetyl-D-glucosamine kinase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10024","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the synthesis of UDP-N-acetyl-glucosamine. Experimental data for one s... | |
medium_hidden_intermediate_10025 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the phosphatidic acid biosynthetic process. Evidence for one such gene reports a log2 fold change of 1.002 and an adjusted p-value of 5.386e-05. Which protein is encoded by that gene? | Diacylglycerol kinase zeta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10025","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the phosphatidic acid biosynthe... | |
medium_hidden_intermediate_10026 | Influenza A virus downregulates a gene that participates in PI Metabolism. Evidence for this gene reports a log2 fold change of -1.408 and an adjusted p-value of 0.008169. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10026","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Influenza A virus downregulates a gene that participates in PI Metabolism. Evidence for this gene reports a log2 fold change... | |
medium_hidden_intermediate_10027 | Ghrelin (GHRL) is involved in a biological process that is a subtype of the positive regulation of multicellular organismal process. Evidence for this specific process describes it as any process that activates or increases the frequency, rate, or extent of the regulated release of corticotropin hormone from a cell. Wh... | corticotropin secretion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10027","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Ghrelin (GHRL) is involved in a biological process that is a subtype of the positive regulation of multicellular organismal ... | |
medium_hidden_intermediate_10029 | Pegivirus C is reported to downregulate multiple genes that are involved in protein O-linked glycosylation. One such gene exhibits a log2 fold change of approximately -2.08 and an adjusted p-value of approximately 0.0099 in peripheral blood mononuclear cells from study GSE131504. Which protein is encoded by this specif... | N-acetylgalactosaminyltransferase 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10029","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate multiple genes that are involved in protein O-linked glycosylation. One such gene ex... | |
medium_hidden_intermediate_10030 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate specific genes involved in the synthesis of substrates for N-glycan biosynthesis. One such gene exhibited a log2 fold change of 1.546 and an adjusted p-value of 3.344e-06. Which biological process is this speci... | fucose metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10030","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate specific genes... | |
medium_hidden_intermediate_10032 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and interacts with PRKN. This specific gene exhibits a log2 fold change of approximately -1.083 and an adjusted p-value of 0.009005. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10032","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and inte... | |
medium_hidden_intermediate_10034 | Vaccinia virus upregulates a gene that is involved in intracellular protein transport. Evidence for one such gene in cervical adenocarcinoma cell lines (study GSE11238) reports a log2 fold change of 1.550 and an adjusted p-value of 2.168e-10. Which disease is associated with genomic alterations in that specific gene? | 3-methylglutaconic aciduria type 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10034","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that is involved in intracellular protein transport. Evidence for one such gene in cervica... | |
medium_hidden_intermediate_10035 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Interferon alpha/beta signaling. Evidence for this gene reports a log2 fold change of 10.344 and an adjusted p-value of 0.01454. Which protein is encoded by this gene? | Interferon alpha-14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10035","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Interferon alpha/beta signalin... | |
medium_hidden_intermediate_10037 | Hepacivirus C upregulates a gene that participates in GPCR downstream signalling. Evidence for this gene reports a log2 fold change of 2.054 and an adjusted p-value of 0.006942. Which protein is encoded by this gene? | C-C motif chemokine 27 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10037","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in GPCR downstream signalling. Evidence for this gene reports a log2 fold... | |
medium_hidden_intermediate_10039 | A gene is upregulated by Primate bocaparvovirus 1 and participates in Signal Transduction. Experimental evidence for this gene reports a log2 fold change of 2.012 and an adjusted p-value of 0.01704. In which cell type is this gene enriched? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10039","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in Signal Transduction. Experimental evidence for this ge... | |
medium_hidden_intermediate_10040 | In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are downregulated and are involved in proteolysis. One such gene exhibits a log2 fold change of -3.121 and an adjusted p-value of 0.02446. Which protein is encoded by this specific gene? | Kallikrein-14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10040","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are downregulated and are invol... |
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