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medium_convergence_00416 | CTNNB1 and ARF6 both interact with a specific protein. Evidence indicates that stimulation by HGF/SF results in the co-precipitation of E-cadherin and beta-catenin with the HGF/SF receptor, which is the protein in question. Which protein is encoded by the gene corresponding to this HGF/SF receptor? | Hepatocyte growth factor receptor | Medium | convergence | {"qa_id":"medium_convergence_00416","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and ARF6 both interact with a specific protein. Evidence indicates that stimulation by HGF/SF results in the co-precipitation of E-cadherin and beta-c... | |
medium_convergence_00417 | FOXK1 and FOXK2 both interact with a specific protein. Evidence indicates that BAP1 recruits a host cell factor to form a ternary complex where BAP1 bridges this shared protein and the host cell factor. Which protein is encoded by the gene corresponding to this shared entity? | Host cell factor 1 | Medium | convergence | {"qa_id":"medium_convergence_00417","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FOXK1 and FOXK2 both interact with a specific protein. Evidence indicates that BAP1 recruits a host cell factor to form a ternary complex where BAP1 bridges ... | |
medium_convergence_00418 | EHMT2 and DNMT1 share interaction partners. One such shared partner is described in the context: 'Here, we show that the human de novo enzymes h[ENTITY] and hDNMT3b form complexes with the major maintenance enzyme hDNMT1.' Which protein is encoded by this shared entity? | DNA (cytosine-5)-methyltransferase 3A | Medium | convergence | {"qa_id":"medium_convergence_00418","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and DNMT1 share interaction partners. One such shared partner is described in the context: 'Here, we show that the human de novo enzymes h[ENTITY] and ... | |
medium_convergence_00419 | FANCB and FAAP24 both interact with a common protein partner. Evidence regarding one such partner states: 'Here, we report a novel component of this complex, termed FAAP100, which is essential for the stability of the core complex and directly interacts with FANCB and this common partner to form a stable subcomplex.' S... | UBE2W | Medium | convergence | {"qa_id":"medium_convergence_00419","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCB and FAAP24 both interact with a common protein partner. Evidence regarding one such partner states: 'Here, we report a novel component of this complex,... | |
medium_convergence_00420 | LY96 and IRAK2 share multiple binding partners. One such shared partner is known to associate with IRAK-2 via its TIR domain. Which protein is encoded by this specific shared partner? | Toll/interleukin-1 receptor domain-containing adapter protein | Medium | convergence | {"qa_id":"medium_convergence_00420","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LY96 and IRAK2 share multiple binding partners. One such shared partner is known to associate with IRAK-2 via its TIR domain. Which protein is encoded by thi... | |
medium_convergence_00421 | TRIM28 and CHEK1 share multiple interacting partners. One such partner is identified in a study reporting the mass spectrometry-based identification of the heterohexamic minichromosome maintenance (MCM) complex interacting with Chk1. Which protein is encoded by this specific shared interacting partner? | DNA replication licensing factor MCM7 | Medium | convergence | {"qa_id":"medium_convergence_00421","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and CHEK1 share multiple interacting partners. One such partner is identified in a study reporting the mass spectrometry-based identification of the h... | |
medium_convergence_00422 | GTF2E1 and CCNT1 both interact with a shared transcription factor subunit. Evidence regarding this shared entity indicates that analyses of its binding to other general transcription factors revealed a defect in binding to the basic helix-loop-helix motif of TFIIEβ. Which disease is associated with this shared entity? | trichothiodystrophy 6, nonphotosensitive | Medium | convergence | {"qa_id":"medium_convergence_00422","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2E1 and CCNT1 both interact with a shared transcription factor subunit. Evidence regarding this shared entity indicates that analyses of its binding to ot... | |
medium_convergence_00423 | HSP90AA1 and IFIH1 both interact with a common protein. Evidence regarding one such shared partner states: 'In the present study, we have identified by yeast two-hybrid approach a specific interaction between this protein and chaperone heat-shock protein of 90 kDa (Hsp90).' Which disease is associated with this shared ... | arteriosclerosis disorder | Medium | convergence | {"qa_id":"medium_convergence_00423","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and IFIH1 both interact with a common protein. Evidence regarding one such shared partner states: 'In the present study, we have identified by yeast... | |
medium_convergence_00424 | CUL5 and RNF7 both interact with a shared protein. Evidence indicates that this shared protein is involved in the formation of a novel E3 ligase through interaction with a complex containing CUL5, ELOB/C, and RNF7, and that deleterious variants affect the binding amount of this protein and CUL5. Which cell type is this... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_00424","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CUL5 and RNF7 both interact with a shared protein. Evidence indicates that this shared protein is involved in the formation of a novel E3 ligase through inte... | |
medium_convergence_00425 | BIRC3 and RNF31 both interact with a specific protein. Evidence indicates that this protein interacts via its PUB domain with CYLD, and a PUB interaction motif (PIM) within this protein interacts with the PUB domain of the LUBAC component HOIP. Which protein is encoded by the gene corresponding to this interacting enti... | Spermatogenesis-associated protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00425","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC3 and RNF31 both interact with a specific protein. Evidence indicates that this protein interacts via its PUB domain with CYLD, and a PUB interaction mot... | |
medium_convergence_00426 | SIN3A and ZBTB16 both interact with a shared protein entity. Experimental evidence regarding a mutant of this entity indicates that it retains the ability to homodimerize and bind to N-CoR, but exhibits only weak binding to mSin3A. Which disease is associated with this entity via a biomarker relationship? | systemic lupus erythematosus | Medium | convergence | {"qa_id":"medium_convergence_00426","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and ZBTB16 both interact with a shared protein entity. Experimental evidence regarding a mutant of this entity indicates that it retains the ability to... | |
medium_convergence_00427 | ESR1 and HIST1H2BB share common interacting partners. One such partner is characterized by an isoform that lacks the RING domain and functions to bind and stabilize estrogen receptor alpha. Which cell type is enriched for this specific interacting partner? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_00427","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HIST1H2BB share common interacting partners. One such partner is characterized by an isoform that lacks the RING domain and functions to bind and st... | |
medium_convergence_00428 | MED1 and NCOA1 both interact with a shared protein. Evidence regarding this shared protein states: 'A mammalian two-hybrid assay was utilized to assess the ability of the farnesoid X receptor to recruit SRC-1 in a ligand-dependent manner.' Which disease is associated with this shared protein as a biomarker? | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_00428","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MED1 and NCOA1 both interact with a shared protein. Evidence regarding this shared protein states: 'A mammalian two-hybrid assay was utilized to assess the a... | |
medium_convergence_00429 | TNK2 and EGFR share common interaction partners. One such partner is described in the following evidence: 'In this study, we have identified SAM domain-carrying non-receptor tyrosine kinase, activated Cdc42-associated tyrosine kinase 1 (ACK1; also known as tyrosine kinase non-receptor 2) as a novel binding partner of a... | immunodeficiency 81 | Medium | convergence | {"qa_id":"medium_convergence_00429","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TNK2 and EGFR share common interaction partners. One such partner is described in the following evidence: 'In this study, we have identified SAM domain-carry... | |
medium_convergence_00430 | LCP2 and NCK1 both interact with a shared protein partner. Evidence indicates that this partner, along with Sos1 and PRK2, associates with Nck and Grb4 proteins and synergizes with v-Abl and Sos to induce gene expression via the transcription factor Elk-1. Which protein is encoded by the gene corresponding to this shar... | Serine/threonine-protein kinase PAK 1 | Medium | convergence | {"qa_id":"medium_convergence_00430","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LCP2 and NCK1 both interact with a shared protein partner. Evidence indicates that this partner, along with Sos1 and PRK2, associates with Nck and Grb4 prote... | |
medium_convergence_00431 | CDKN2A and EP300 both interact with a shared protein target. One piece of evidence regarding this target states: 'Here we show that an important tumor suppressor protein, p14ARF (alternative reading frame product of the INK4A locus) can directly inhibit the transcriptional activity of HIF-1 by sequestering its alpha su... | Hypoxia-inducible factor 1-alpha | Medium | convergence | {"qa_id":"medium_convergence_00431","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN2A and EP300 both interact with a shared protein target. One piece of evidence regarding this target states: 'Here we show that an important tumor suppre... | |
medium_convergence_00432 | Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data from foreskin fibroblast cell lines (study GSE111036) indicate that this gene has a log2 fold change of -1.374 and an adjusted p-value of 0.0288. Which protein is encoded by this gene? | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_00432","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data from foreskin fibroblast cell lines (study GSE111036) indicate ... | |
medium_convergence_00433 | ARRB2 and MDM2 share multiple interacting partners. One such partner is described by evidence stating that a protein kinase encoded by PRKCB interacts with β-arrestin2 upon autophosphorylation at T250, thereby inhibiting receptor internalization by decreasing the ubiquitination of β-arrestin2. Which protein is encoded ... | Protein kinase C beta type | Medium | convergence | {"qa_id":"medium_convergence_00433","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARRB2 and MDM2 share multiple interacting partners. One such partner is described by evidence stating that a protein kinase encoded by PRKCB interacts with β... | |
medium_convergence_00434 | DCTN1 and DYNC1LI1 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'Using the yeast two-hybrid system, we found that this protein also binds to dynactin P150(Glued) (P150), an accessory protein for cytoplasmic dynein that participates in microtubule-dependent re... | Huntingtin-associated protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00434","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCTN1 and DYNC1LI1 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'Using the yeast two-hybrid syst... | |
medium_convergence_00435 | EIF3H and EIF3I both interact with a shared protein partner. Evidence regarding this partner states: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which protein is encoded by the gene corresponding to this shared partner? | Eukaryotic translation initiation factor 3 subunit M | Medium | convergence | {"qa_id":"medium_convergence_00435","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3H and EIF3I both interact with a shared protein partner. Evidence regarding this partner states: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 i... | |
medium_convergence_00436 | CLSPN and CDC6 both interact with a shared protein partner. Evidence indicates that the interaction between Claspin and this specific DNA helicase subunit is abolished when Cdc7 is inhibited. Which protein is encoded by this shared partner? | DNA replication licensing factor MCM2 | Medium | convergence | {"qa_id":"medium_convergence_00436","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLSPN and CDC6 both interact with a shared protein partner. Evidence indicates that the interaction between Claspin and this specific DNA helicase subunit is... | |
medium_convergence_00437 | TRAF2 and TRAF3 both interact with a shared protein. Experimental evidence from a coimmunoprecipitation study indicates that either TRAF2 or TRAF3 binds to this shared protein. Which gene product does this shared protein bind to? | CD70 | Medium | convergence | {"qa_id":"medium_convergence_00437","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRAF2 and TRAF3 both interact with a shared protein. Experimental evidence from a coimmunoprecipitation study indicates that either TRAF2 or TRAF3 binds to t... | |
medium_convergence_00438 | EP300 and KLF3 both interact with a shared transcription factor. Evidence indicates that P300 and PCAF act as cofactors for this specific entity, forming a P300/PCAF/entity complex on the miR200c/141 promoter. Which protein is encoded by this entity? | Zinc finger E-box-binding homeobox 1 | Medium | convergence | {"qa_id":"medium_convergence_00438","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and KLF3 both interact with a shared transcription factor. Evidence indicates that P300 and PCAF act as cofactors for this specific entity, forming a P... | |
medium_convergence_00440 | BRD4 and ASF1A share a common interaction partner. Evidence regarding this shared entity states: 'Furthermore, we demonstrate that hAsf1 proteins can interact directly with the p60 subunit of hCAF-1.' Which protein is encoded by this shared interaction partner? | Chromatin assembly factor 1 subunit B | Medium | convergence | {"qa_id":"medium_convergence_00440","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and ASF1A share a common interaction partner. Evidence regarding this shared entity states: 'Furthermore, we demonstrate that hAsf1 proteins can interac... | |
medium_convergence_00441 | CCNB1 and CDC20 each interact with more than one shared protein. Evidence concerning one shared entity reports that while phosphorylation of a specific serine residue in the APC/C coactivator prevents delivery of this entity to the APC/C, removal of this mark by PP2A(B56) allows this entity to bind the APC/C and cataly... | Ubiquitin-conjugating enzyme E2 S | Medium | convergence | {"qa_id":"medium_convergence_00441","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCNB1 and CDC20 each interact with more than one shared protein. Evidence concerning one shared entity reports that while phosphorylation of a specific serin... | |
medium_convergence_00442 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.244 and an adjusted p-value of 0.005766. Which disease is associated with this gene through genomic alterations? | brain cancer | Medium | convergence | {"qa_id":"medium_convergence_00442","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Evidence for this gene in a monocytic leukemia cell line (study GSE1149... | |
medium_convergence_00443 | ELOC and RNF7 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In immunoprecipitation studies, both Elongin C and Cullin-5, components of the multi-subunit E3 ubiquitin ligase, were found to bind to iNOS via [the shared partner], SPSB2, or SPSB4.' Which cellu... | cytosol | Medium | convergence | {"qa_id":"medium_convergence_00443","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ELOC and RNF7 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In immunoprecipitation studies, b... | |
medium_convergence_00444 | ERCC4 and FAAP24 both interact with a specific protein. Evidence indicates that this protein forms a conserved DNA-remodeling complex with the histone-fold heterodimer MHF. Which protein is encoded by the gene corresponding to this entity? | Fanconi anemia group M protein | Medium | convergence | {"qa_id":"medium_convergence_00444","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC4 and FAAP24 both interact with a specific protein. Evidence indicates that this protein forms a conserved DNA-remodeling complex with the histone-fold h... | |
medium_convergence_00446 | GAB3 and IL4R both interact with a shared protein. Experimental evidence for this protein describes assays involving recombinant proteins with C-terminal deletions or double alanine substitutions, testing for DNA binding, transcription activation, tyrosine phosphorylation, and interaction with a tyrosine-phosphorylated... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_00446","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GAB3 and IL4R both interact with a shared protein. Experimental evidence for this protein describes assays involving recombinant proteins with C-terminal del... | |
medium_convergence_00447 | Both Human immunodeficiency virus 1 and Dengue virus are reported to downregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) shows a log2 fold change of approximately -2.54 and an adjusted p-value of approximately 0.0035. Which protein is encoded by this gene? | StAR-related lipid transfer protein 13 | Medium | convergence | {"qa_id":"medium_convergence_00447","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are reported to downregulate a specific gene. Experimental data for this gene in macrophages (from study... | |
medium_convergence_00448 | RB1 and STK4 both interact with a specific shared protein. Evidence for one of these interactions states: 'We have used the yeast two-hybrid system to screen for cellular proteins which bind to the first 300 amino acids of p110RB.' Which protein is encoded by the gene corresponding to this shared interaction partner? | THO complex subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_00448","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RB1 and STK4 both interact with a specific shared protein. Evidence for one of these interactions states: 'We have used the yeast two-hybrid system to screen... | |
medium_convergence_00449 | CUL3 and KEAP1 both interact with a specific protein that acts as a negative regulator of the antioxidative transcription factor NFE2L2. Evidence indicates that this protein binds to CUL3 via its BTB domain and to NFE2L2 via its Kelch domain. Which protein is encoded by the gene corresponding to this entity? | Nuclear factor erythroid 2-related factor 2 | Medium | convergence | {"qa_id":"medium_convergence_00449","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CUL3 and KEAP1 both interact with a specific protein that acts as a negative regulator of the antioxidative transcription factor NFE2L2. Evidence indicates t... | |
medium_convergence_00450 | IRAK1 and IRAK2 both interact with a shared adaptor protein. Evidence regarding this protein states: 'The bipartite nature of the protein (N-terminal death domain [DD] and COOH-terminal Toll/IL-1 receptor [TIR] domain) allows it to link the TIR domain of IL-1R/TLR with the DD of the Ser/Thr kinase termed IL-1R-associat... | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_00450","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IRAK1 and IRAK2 both interact with a shared adaptor protein. Evidence regarding this protein states: 'The bipartite nature of the protein (N-terminal death d... | |
medium_convergence_00451 | CHAF1A and UBN1 both interact with a shared protein entity. Evidence regarding this entity states: 'For example, we found that the chromatin assembly factor-1 histone chaperone not only deposits the replication-coupled H3.1 histone variant during S-phase but also associates with H3.3 throughout the cell cycle in vivo.'... | Histone H3.3 | Medium | convergence | {"qa_id":"medium_convergence_00451","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHAF1A and UBN1 both interact with a shared protein entity. Evidence regarding this entity states: 'For example, we found that the chromatin assembly factor-... | |
medium_convergence_00452 | Cyproheptadine and Carbinoxamine both interact with a specific shared drug. Evidence indicates that this shared drug enhanced the anticonvulsive action of most benzodiazepines tested. Which disease is this shared drug indicated for? | alcohol withdrawal | Medium | convergence | {"qa_id":"medium_convergence_00452","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cyproheptadine and Carbinoxamine both interact with a specific shared drug. Evidence indicates that this shared drug enhanced the anticonvulsive action of mo... | |
medium_convergence_00453 | Morphine and Tripelennamine both interact with a specific drug. Evidence regarding this drug states: 'While tricyclics had no effect on basal pain responsivity, they potentiated morphine analgesia in rank-order with their potency as TLR4 inhibitors.' Which disease is this drug indicated for? | fibromyalgia | Medium | convergence | {"qa_id":"medium_convergence_00453","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Morphine and Tripelennamine both interact with a specific drug. Evidence regarding this drug states: 'While tricyclics had no effect on basal pain responsivi... | |
medium_convergence_00454 | FGF2 and FGF9 both interact with a specific protein receptor. Experimental evidence indicates that FGF-2 binds well to this receptor, as well as to FGFR2 and FGFR4, but interacts poorly with KGFR. Which protein is encoded by the gene corresponding to this receptor? | Fibroblast growth factor receptor 1 | Medium | convergence | {"qa_id":"medium_convergence_00454","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF2 and FGF9 both interact with a specific protein receptor. Experimental evidence indicates that FGF-2 binds well to this receptor, as well as to FGFR2 and... | |
medium_convergence_00455 | CEP131 and CCP110 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We have purified complexes associated with CP110, a protein that plays an essential role in centrosome duplication and cytokinesis, and have identified a previously uncharacterized protein, that recruits C... | Centrosomal protein of 97 kDa | Medium | convergence | {"qa_id":"medium_convergence_00455","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEP131 and CCP110 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We have purified complexes associated with... | |
medium_convergence_00456 | BRD8 and DMAP1 share multiple binding partners. One such shared partner is part of a newly identified abundant native complex composed of a protein encoded by MORF4L1, X-MRGBP, BRD8, and EP400NL (EP400 N-terminal like), which is functionally similar to the yeast TINTIN complex. Which protein is encoded by this shared p... | Mortality factor 4-like protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00456","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD8 and DMAP1 share multiple binding partners. One such shared partner is part of a newly identified abundant native complex composed of a protein encoded b... | |
medium_convergence_00457 | CENPS and BLM both interact with a specific shared protein. Biochemical evidence indicates that MHF1 and MHF2 form a heterodimer that binds DNA and enhances the DNA branch migration activity of this shared protein. Which gene interacts with this shared protein? | TELO2 | Medium | convergence | {"qa_id":"medium_convergence_00457","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPS and BLM both interact with a specific shared protein. Biochemical evidence indicates that MHF1 and MHF2 form a heterodimer that binds DNA and enhances ... | |
medium_convergence_00458 | DNAJA2 and HSP90AA1 both interact with a specific shared protein. Experimental evidence indicates that this protein is bound by Hsp90 and Cdc37 in 293T cells, whereas a related kinase is not bound by these chaperones. Which protein product is encoded by this shared interacting partner? | Interleukin-1 receptor-associated kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_00458","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNAJA2 and HSP90AA1 both interact with a specific shared protein. Experimental evidence indicates that this protein is bound by Hsp90 and Cdc37 in 293T cells... | |
medium_convergence_00459 | CHEK1 and CHEK2 both interact with a specific shared protein entity. Experimental evidence indicates that Chk1 binds to and phosphorylates this entity, along with Cdc25A and Cdc25B, which are dual-specificity protein phosphatases that control cell cycle transitions by dephosphorylating cyclin-dependent kinases. Which p... | M-phase inducer phosphatase 3 | Medium | convergence | {"qa_id":"medium_convergence_00459","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and CHEK2 both interact with a specific shared protein entity. Experimental evidence indicates that Chk1 binds to and phosphorylates this entity, along... | |
medium_convergence_00461 | ALK and HRAS both interact with a common protein. Evidence indicates that this shared protein associates with active Ras, but not with inactive Ras or Raf. Which protein is encoded by the gene corresponding to this shared entity? | Erbin | Medium | convergence | {"qa_id":"medium_convergence_00461","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALK and HRAS both interact with a common protein. Evidence indicates that this shared protein associates with active Ras, but not with inactive Ras or Raf. W... | |
medium_convergence_00462 | ATM and RAD51 each share a common binding partner. Evidence concerning one such shared entity states: 'In assays using purified components, phosphorylation of Rad51 by c-Abl enhances complex formation between Rad51 and this shared entity, which cooperates with Rad51 in recombination and repair.' Which gene interacts wi... | SUMO1 | Medium | convergence | {"qa_id":"medium_convergence_00462","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and RAD51 each share a common binding partner. Evidence concerning one such shared entity states: 'In assays using purified components, phosphorylation o... | |
medium_convergence_00464 | ALK and LAMP1 share multiple protein interaction partners. One such shared partner was identified via LC/MS-MS analysis, which detected multiple proteins, including this partner and SHP2, and validated them as interactors of ALK in neuroblastoma (NB) cells. Which protein is encoded by the gene corresponding to this sha... | Inactive tyrosine-protein kinase PEAK1 | Medium | convergence | {"qa_id":"medium_convergence_00464","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALK and LAMP1 share multiple protein interaction partners. One such shared partner was identified via LC/MS-MS analysis, which detected multiple proteins, in... | |
medium_convergence_00465 | Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of approximately -1.58 and an adjusted p-value of approximately 0.0046. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_00465","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114... | |
medium_convergence_00468 | EGFR and ERBB2 each interact with more than one shared gene product. Evidence concerning one such shared entity states: 'In the present study, the c-erbB-2 gene product was shown by far-Western blotting analysis to associate directly with both beta-catenin and plakoglobin through its cytoplasmic domain core region, whi... | Parkinson disease | Medium | convergence | {"qa_id":"medium_convergence_00468","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and ERBB2 each interact with more than one shared gene product. Evidence concerning one such shared entity states: 'In the present study, the c-erbB-2 g... | |
medium_convergence_00469 | Both Human alphaherpesvirus 1 and Zika virus are known to upregulate a specific host gene. Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that for one such shared target, the log2 fold change is approximately 1.127 and the adjusted p-value is 0.02598. What molecular function is enable... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_00469","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Zika virus are known to upregulate a specific host gene. Experimental data from a monocytic leukemia cell line (study GSE11... | |
medium_convergence_00470 | Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicates that for one of these shared targets, the log2 fold change is 1.711 and the adjusted p-value is 0.008138. What molecular function is enabled by this specific gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_00470","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicates that fo... | |
medium_convergence_00471 | MORF4L1 and ACTL6A both interact with a shared protein partner. Evidence indicates that MRFAP1 binds to several E3 ubiquitin ligases, such as CUL4B, but does not bind to components of the NuA4 complex, specifically excluding the shared partner in question. This shared partner is known to bind MORF4L1. Which protein is ... | MRG/MORF4L-binding protein | Medium | convergence | {"qa_id":"medium_convergence_00471","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MORF4L1 and ACTL6A both interact with a shared protein partner. Evidence indicates that MRFAP1 binds to several E3 ubiquitin ligases, such as CUL4B, but does... | |
medium_convergence_00472 | CDK2 and ORC2 share multiple binding partners. One such shared partner is implicated in a study reporting the following binary interactions: HsOrc2-HsOrc3, HsOrc2-HsOrc4, HsOrc3-HsOrc4, HsOrc2-HsOrc6, and HsOrc3-HsOrc6. Which disease is associated with this specific shared partner? | Meier-Gorlin syndrome 3 | Medium | convergence | {"qa_id":"medium_convergence_00472","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and ORC2 share multiple binding partners. One such shared partner is implicated in a study reporting the following binary interactions: HsOrc2-HsOrc3, H... | |
medium_convergence_00473 | JOSD2 and AR share multiple interacting partners. One such shared partner is characterized by evidence stating that androgen antagonists induce the recruitment of prohibitin and BRG1 to endogenous promoters responsive to this entity, and induce a physical association between this entity, prohibitin, and BRG1. Which pro... | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 | Medium | convergence | {"qa_id":"medium_convergence_00473","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"JOSD2 and AR share multiple interacting partners. One such shared partner is characterized by evidence stating that androgen antagonists induce the recruitme... | |
medium_convergence_00474 | Eptifibatide and Icosapent both interact with a specific anticoagulant agent. Clinical evidence regarding this agent describes a study where plasma levels and activated clotting times (ACTs) were assessed periprocedurally in 152 patients administered the agent (250- or 300-microg/kg bolus, then 15-microg/kg/min infusio... | heparin-induced thrombocytopenia | Medium | convergence | {"qa_id":"medium_convergence_00474","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Eptifibatide and Icosapent both interact with a specific anticoagulant agent. Clinical evidence regarding this agent describes a study where plasma levels an... | |
medium_convergence_00475 | ERCC2 and CUL4B share multiple protein interaction partners. One such shared partner is described as interacting with multiple subunits of the TFIIH complex and with the CSB protein. Which protein is encoded by the gene corresponding to this shared partner? | DNA excision repair protein ERCC-5 | Medium | convergence | {"qa_id":"medium_convergence_00475","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC2 and CUL4B share multiple protein interaction partners. One such shared partner is described as interacting with multiple subunits of the TFIIH complex ... | |
medium_convergence_00476 | HDAC1 and HDAC2 both interact with a specific transcription factor. Experimental evidence demonstrates that a ternary complex consisting of this transcription factor, p65/RelA, and HDAC1 is formed in vivo. Which protein is encoded by the gene corresponding to this transcription factor? | Peroxisome proliferator-activated receptor delta | Medium | convergence | {"qa_id":"medium_convergence_00476","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and HDAC2 both interact with a specific transcription factor. Experimental evidence demonstrates that a ternary complex consisting of this transcriptio... | |
medium_convergence_00477 | KRT23 and KRT18 both interact with a shared protein partner. Evidence regarding this partner states: 'The explanation does not appear to reside in an inability of K18 to form 10-nm filaments with K5, which it does in vitro and in vivo.' Which biological process is this shared partner involved in? | epidermis development | Medium | convergence | {"qa_id":"medium_convergence_00477","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRT23 and KRT18 both interact with a shared protein partner. Evidence regarding this partner states: 'The explanation does not appear to reside in an inabili... | |
medium_convergence_00478 | PSME3 and ESRRA both interact with a shared protein entity. Evidence indicates that this entity, also known as a nuclear receptor coactivator, interacts with REGgamma, a proteasome activator that stimulates the trypsin-like activity of the 20S proteasome. Which protein product is encoded by this shared entity? | Nuclear receptor coactivator 3 | Medium | convergence | {"qa_id":"medium_convergence_00478","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSME3 and ESRRA both interact with a shared protein entity. Evidence indicates that this entity, also known as a nuclear receptor coactivator, interacts with... | |
medium_convergence_00479 | Dengue virus and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data from a hepatoma cell line (study GSE110512) indicates that this gene has a log2 fold change of approximately -1.81 and an adjusted p-value of 0.02185. Which protein does this gene product interact with? | SQSTM1 | Medium | convergence | {"qa_id":"medium_convergence_00479","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data from a hepatoma cell line (study GSE110512) indicates that thi... | |
medium_convergence_00480 | COL1A1 and ACTB share multiple binding partners. One shared partner is characterized by evidence stating: 'Cultured cells synthesized proalpha2(I) chains that were slow to assemble with proalpha1(I) chains to form heterotrimers and that were retained intracellularly.' Which disease is associated with this specific shar... | dental fluorosis | Medium | convergence | {"qa_id":"medium_convergence_00480","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COL1A1 and ACTB share multiple binding partners. One shared partner is characterized by evidence stating: 'Cultured cells synthesized proalpha2(I) chains tha... | |
medium_convergence_00481 | ESR1 and HECTD1 share multiple interacting partners. One such shared partner is described in evidence stating: 'We present evidence that DRIP205 interacts with another member of the steroid receptor subfamily, estrogen receptor (ER).' Which protein product is encoded by this shared interacting partner? | Mediator of RNA polymerase II transcription subunit 14 | Medium | convergence | {"qa_id":"medium_convergence_00481","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HECTD1 share multiple interacting partners. One such shared partner is described in evidence stating: 'We present evidence that DRIP205 interacts wi... | |
medium_convergence_00482 | YWHAQ and YWHAE both interact with a shared gene. Evidence for this shared entity states: 'We demonstrate direct and robust interaction between h[entity] and six of the seven 14-3-3 isoforms in vitro, suggestive of a novel protein interaction network between DNA repair and cell cycle control.' Which gene does this shar... | DCAF1 | Medium | convergence | {"qa_id":"medium_convergence_00482","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and YWHAE both interact with a shared gene. Evidence for this shared entity states: 'We demonstrate direct and robust interaction between h[entity] and... | |
medium_convergence_00483 | GNA13 and GNA15 both interact with a specific receptor. Experimental evidence indicates that purification of this receptor using the ligand SQ31,491 resulted in the co-purification of a member of the G12 family (specifically Galpha13). Which disease is associated with this receptor as a biomarker? | lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00483","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNA13 and GNA15 both interact with a specific receptor. Experimental evidence indicates that purification of this receptor using the ligand SQ31,491 resulted... | |
medium_convergence_00484 | Human alphaherpesvirus 3 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of 5.024 and an adjusted p-value of 1.057e-10. Which protein is encoded by this gene? | Interferon beta | Medium | convergence | {"qa_id":"medium_convergence_00484","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports ... | |
medium_convergence_00486 | Both Measles morbillivirus and Influenza A virus are reported to downregulate a specific shared gene. Experimental evidence for this gene shows a log2 fold change of -1.114 and an adjusted p-value of 0.0008106. Which cellular component is this gene located in? | lipid droplet | Medium | convergence | {"qa_id":"medium_convergence_00486","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus are reported to downregulate a specific shared gene. Experimental evidence for this gene shows a log2 fold c... | |
medium_convergence_00487 | HMG20B and HDAC1 both interact with a specific shared protein partner. Evidence indicates that two isoforms of a PHD finger-containing protein were distinguished by reduced binding to this shared partner and HDAC2, despite the presence of the PHD finger domain. Which protein is encoded by the gene corresponding to this... | PHD finger protein 21A | Medium | convergence | {"qa_id":"medium_convergence_00487","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HMG20B and HDAC1 both interact with a specific shared protein partner. Evidence indicates that two isoforms of a PHD finger-containing protein were distingui... | |
medium_convergence_00488 | EXOSC7 and NCBP1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that the protein binds the cap-binding complex (CBC), which is universally present on capped RNAs, and also associates with the nuclear exosome targeting (NEXT) complex, thereby linking t... | Zinc finger CCCH domain-containing protein 18 | Medium | convergence | {"qa_id":"medium_convergence_00488","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EXOSC7 and NCBP1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that the protein binds t... | |
medium_convergence_00489 | Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of -1.413 and an adjusted p-value of 0.001292. Which disease is associated with this gene through genomic alterations? | tuberculosis | Medium | convergence | {"qa_id":"medium_convergence_00489","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475... | |
medium_convergence_00490 | HDAC1 and DPF2 both interact with a shared protein. Evidence indicates that in the ovary, this shared protein interacts with the NuRD complex proteins CHD4 and HDAC1, as well as the core cohesin complex protein RAD21. Which protein is encoded by the gene corresponding to this shared entity? | Metastasis-associated protein MTA3 | Medium | convergence | {"qa_id":"medium_convergence_00490","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and DPF2 both interact with a shared protein. Evidence indicates that in the ovary, this shared protein interacts with the NuRD complex proteins CHD4 a... | |
medium_convergence_00491 | CDK12 and CCNH both interact with a shared protein partner. Evidence regarding this partner states: 'Here we use a yeast two-hybrid screen to show that a new human cyclin (cyclin H) is a [REDACTED]-associated protein.' Which protein is encoded by the gene corresponding to this shared partner? | Cyclin-dependent kinase 7 | Medium | convergence | {"qa_id":"medium_convergence_00491","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK12 and CCNH both interact with a shared protein partner. Evidence regarding this partner states: 'Here we use a yeast two-hybrid screen to show that a new... | |
medium_convergence_00492 | CREB1 and HINT1 each interact with more than one shared protein. Evidence concerning one of these shared proteins states: 'We found that HINT1 inhibits this shared protein and β-catenin transcriptional activity, and both proteins can be co-immunoprecipitated with an anti-HINT1-specific antibody in melanoma cell lines.'... | Microphthalmia-associated transcription factor | Medium | convergence | {"qa_id":"medium_convergence_00492","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREB1 and HINT1 each interact with more than one shared protein. Evidence concerning one of these shared proteins states: 'We found that HINT1 inhibits this ... | |
medium_convergence_00494 | Human polyomavirus 1 and Measles morbillivirus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (from study GSE135833) reports a log2 fold change of approximately 1.616 and an adjusted p-value of 0.01905. Which disease is associated with this gene as a biomarker? | myelodysplastic syndrome | Medium | convergence | {"qa_id":"medium_convergence_00494","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Measles morbillivirus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (from study GSE1358... | |
medium_convergence_00495 | PSMA3 and PSMA4 both interact with a common protein partner. Evidence regarding this partner states: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' What molecular function is enabled by this share... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_00495","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMA3 and PSMA4 both interact with a common protein partner. Evidence regarding this partner states: 'In the present study, we demonstrate that the 20S prote... | |
medium_convergence_00496 | PSME3 and MAPK14 both interact with a shared protein. Evidence indicates that in vitro, p38 binds and phosphorylates this shared protein at serines 309 and 361, and also phosphorylates Cdc25C at serine 216; phosphorylation of these residues is required for binding to 14-3-3 proteins. Which protein is encoded by the gen... | M-phase inducer phosphatase 2 | Medium | convergence | {"qa_id":"medium_convergence_00496","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSME3 and MAPK14 both interact with a shared protein. Evidence indicates that in vitro, p38 binds and phosphorylates this shared protein at serines 309 and 3... | |
medium_convergence_00497 | Human respirovirus 3 and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) reports a log2 fold change of 1.446 and an adjusted p-value of 0.04936. Which protein is encoded by this gene? | Metallothionein-2 | Medium | convergence | {"qa_id":"medium_convergence_00497","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line ... | |
medium_convergence_00498 | PEX12 and ACOX3 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'Using two-hybrid studies, blot overlay assays, and coimmunoprecipitation experiments, we observed that the zinc-binding domain of PEX12 binds both this shared entity, the PTS1 receptor, and PEX10, ... | Peroxisomal targeting signal 1 receptor | Medium | convergence | {"qa_id":"medium_convergence_00498","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PEX12 and ACOX3 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'Using two-hybrid studies, blot ove... | |
medium_convergence_00499 | PPP1R13L and TSC22D3 both interact with a shared protein entity. Contextual evidence specifies that GILZ inhibits the nuclear translocation and DNA binding of this shared entity through direct protein-to-protein interaction with its subunits. Which cell type is enriched with this specific shared entity? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_00499","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP1R13L and TSC22D3 both interact with a shared protein entity. Contextual evidence specifies that GILZ inhibits the nuclear translocation and DNA binding o... | |
medium_convergence_00500 | Rhinovirus A and Cardiovirus A both upregulate a specific gene. In a study of cytotoxic T-lymphocytes (GSE106475), this gene showed a log2 fold change of approximately 2.64 and an adjusted p-value of 0.01944. Which protein is encoded by this gene? | Ketimine reductase mu-crystallin | Medium | convergence | {"qa_id":"medium_convergence_00500","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Cardiovirus A both upregulate a specific gene. In a study of cytotoxic T-lymphocytes (GSE106475), this gene showed a log2 fold change of app... | |
medium_convergence_00502 | MAPK1 and MAPK3 share a common interacting partner. Evidence regarding one such partner states: 'We report the physical and functional association of ERK1/2 with the PTP-SL and [redacted] protein tyrosine phosphatases (PTPs).' Which disease is associated with this specific entity via a biomarker relationship? | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_00502","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK1 and MAPK3 share a common interacting partner. Evidence regarding one such partner states: 'We report the physical and functional association of ERK1/2 ... | |
medium_convergence_00503 | Both Human respirovirus 3 and Human immunodeficiency virus 1 are reported to upregulate a specific shared gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) indicates a log2 fold change of approximately 2.83 and an adjusted p-value of 0.0422. Which cellular compone... | extracellular matrix | Medium | convergence | {"qa_id":"medium_convergence_00503","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Human immunodeficiency virus 1 are reported to upregulate a specific shared gene. Experimental data for this gene in a non-smal... | |
medium_convergence_00504 | TCF4 and TCF12 both interact with a shared protein. Evidence indicates that this shared protein binds the promoter of the melanoma metastasis-suppressing gene KiSS1 and enhances its expression through interaction with E12 (a TCF3 isoform) and TCF12. Which protein is encoded by the gene corresponding to this shared enti... | Transcription factor 21 | Medium | convergence | {"qa_id":"medium_convergence_00504","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TCF4 and TCF12 both interact with a shared protein. Evidence indicates that this shared protein binds the promoter of the melanoma metastasis-suppressing gen... | |
medium_convergence_00506 | EP300 and RICTOR both interact with a shared protein. Evidence indicates that following mitogen stimulation, S6Ks interact with the p300 and p300/CBP-associated factor (PCAF) acetyltransferases. Which protein is encoded by the gene corresponding to this shared entity? | Ribosomal protein S6 kinase beta-1 | Medium | convergence | {"qa_id":"medium_convergence_00506","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and RICTOR both interact with a shared protein. Evidence indicates that following mitogen stimulation, S6Ks interact with the p300 and p300/CBP-associa... | |
medium_convergence_00507 | CENPI and HJURP both interact with a shared protein partner. Evidence indicates that this partner is recruited to centromeres through a direct interaction between its centromere targeting domain and the Mis18α-β C-terminal coiled-coil domains. Which protein is encoded by the gene corresponding to this shared partner? | Protein Mis18-alpha | Medium | convergence | {"qa_id":"medium_convergence_00507","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPI and HJURP both interact with a shared protein partner. Evidence indicates that this partner is recruited to centromeres through a direct interaction be... | |
medium_convergence_00508 | Gastrin (GAST) and Cholecystokinin (CCK) both bind to a specific receptor protein. Experimental evidence indicates that probes for these ligands bound to type B receptors in a saturable and specific manner, acting as full agonists. Which protein is encoded by the gene corresponding to this type B receptor? | Gastrin/cholecystokinin type B receptor | Medium | convergence | {"qa_id":"medium_convergence_00508","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Gastrin (GAST) and Cholecystokinin (CCK) both bind to a specific receptor protein. Experimental evidence indicates that probes for these ligands bound to typ... | |
medium_convergence_00509 | YAP1 and CUL3 share multiple interacting partners. One such partner is described in experimental evidence stating: 'In co-immunoprecipitation assays, we discover that this protein physically associated with YAP/TAZ and furthermore disrupts the interaction between YAP and β-TrCP E3 ubiquitin ligase, which promotes YAP p... | Actin-like protein 6A | Medium | convergence | {"qa_id":"medium_convergence_00509","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and CUL3 share multiple interacting partners. One such partner is described in experimental evidence stating: 'In co-immunoprecipitation assays, we disc... | |
medium_convergence_00510 | BRD4 and HDAC2 share multiple interaction partners. One such shared partner is implicated in a specific disease. Evidence indicates that Coimmunoprecipitation experiments show HDAC1 and this shared entity are associated with Topo II in vivo under normal physiological conditions. Which disease is associated with this sh... | B-cell immunodeficiency, distal limb anomalies, and urogenital malformations | Medium | convergence | {"qa_id":"medium_convergence_00510","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and HDAC2 share multiple interaction partners. One such shared partner is implicated in a specific disease. Evidence indicates that Coimmunoprecipitatio... | |
medium_convergence_00511 | Both Vaccinia virus and Cardiovirus A are reported to upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of approximately 1.56 and an adjusted p-value of 1.09e-07. In which cell type is this gene reported to be enriched? | classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_00511","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Cardiovirus A are reported to upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (stu... | |
medium_convergence_00512 | RRAGA and AKT1S1 share multiple binding partners. One shared partner is described in evidence stating that Rag A associates with both Rag C and Rag D in their C-terminal regions, where a potential leucine zipper motif and a coiled-coil structure were identified. Which protein corresponds to this shared partner? | Ras-related GTP-binding protein D | Medium | convergence | {"qa_id":"medium_convergence_00512","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RRAGA and AKT1S1 share multiple binding partners. One shared partner is described in evidence stating that Rag A associates with both Rag C and Rag D in thei... | |
medium_convergence_00513 | KIF20A and MAD2L2 both interact with a specific shared protein. Evidence regarding this shared entity states: 'In addition, we have identified an interaction between hREV7 and hMAD2 but not hMAD1.' Which protein is encoded by this shared entity? | Mitotic spindle assembly checkpoint protein MAD2A | Medium | convergence | {"qa_id":"medium_convergence_00513","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KIF20A and MAD2L2 both interact with a specific shared protein. Evidence regarding this shared entity states: 'In addition, we have identified an interaction... | |
medium_convergence_00514 | CRY2 and CSNK1D both interact with a specific shared protein. Evidence regarding this protein states: 'We have now extended our previous studies to show that human casein kinase Idelta (hCKIdelta), the closest homologue to hCKIepsilon, associates with and phosphorylates hPER1 and causes protein instability.' Which cell... | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_00514","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRY2 and CSNK1D both interact with a specific shared protein. Evidence regarding this protein states: 'We have now extended our previous studies to show that... | |
medium_convergence_00515 | F2 and APOE are both involved in more than one shared biological process. Evidence concerning one of these shared entities states: 'We conclude that apoE inhibits platelet aggregation through the L-arginine:NO signal transduction pathway.' Which biological process is negatively regulated by that specific entity? | platelet activation | Medium | convergence | {"qa_id":"medium_convergence_00515","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"F2 and APOE are both involved in more than one shared biological process. Evidence concerning one of these shared entities states: 'We conclude that apoE inh... | |
medium_convergence_00516 | FANCG and BLM both interact with a specific protein. Experimental evidence indicates that TPR-mutated FANCG proteins fail to interact with BRCA2, this specific protein, FANCA, or FANCF. Which protein is encoded by the gene corresponding to this specific protein? | DNA repair protein XRCC3 | Medium | convergence | {"qa_id":"medium_convergence_00516","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCG and BLM both interact with a specific protein. Experimental evidence indicates that TPR-mutated FANCG proteins fail to interact with BRCA2, this specif... | |
medium_convergence_00517 | Insulin human (inhalation, rapid acting) and Calcitriol (topical) share a common interacting drug. Clinical evidence indicates that the combination of hormone replacement therapy/estrogen replacement therapy and calcitriol significantly increased bone mineral density at the femoral neck, spine, total hip, and trochante... | postmenopausal osteoporosis | Medium | convergence | {"qa_id":"medium_convergence_00517","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Insulin human (inhalation, rapid acting) and Calcitriol (topical) share a common interacting drug. Clinical evidence indicates that the combination of hormon... | |
medium_convergence_00518 | ARPC4 and CDC42 share a common binding partner. Evidence regarding this partner indicates that mutations such as V42A and L174A in CDC42 cause large, selective changes in binding to specific CRIB effectors. Specifically, neither mutation alters PAK binding, both severely disrupt binding to ACK, and only the L174A mutat... | severe congenital neutropenia | Medium | convergence | {"qa_id":"medium_convergence_00518","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC4 and CDC42 share a common binding partner. Evidence regarding this partner indicates that mutations such as V42A and L174A in CDC42 cause large, selecti... | |
medium_convergence_00519 | GABRA4 and GABRB1 are both involved in multiple shared biological processes. One of these shared processes is supported by evidence stating: 'we determined the impact of GABRB mutations on GABAA receptor function and biogenesis.' Which broader biological process is this specific shared process a subclass of (is_a)? | cell-cell signaling | Medium | convergence | {"qa_id":"medium_convergence_00519","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GABRA4 and GABRB1 are both involved in multiple shared biological processes. One of these shared processes is supported by evidence stating: 'we determined t... | |
medium_convergence_00520 | LRP4 and SALL1 are both involved in multiple shared biological processes. One of these processes is linked to a condition characterized mainly by syndactyly and/or oligodactyly, which is now shown to be commonly associated with kidney anomalies. Which biological process is connected to that condition through the 'is a'... | animal organ development | Medium | convergence | {"qa_id":"medium_convergence_00520","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LRP4 and SALL1 are both involved in multiple shared biological processes. One of these processes is linked to a condition characterized mainly by syndactyly ... | |
medium_convergence_00521 | KAT5 and EPC2 both interact with a specific protein that serves as a stable subunit of a complex. Evidence indicates that this protein contains a histone reader domain for H4K20me1/2, which enables TIP60 to associate with specific gene promoters and promotes the repair of DNA double-strand breaks via homologous recombi... | MBT domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00521","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and EPC2 both interact with a specific protein that serves as a stable subunit of a complex. Evidence indicates that this protein contains a histone rea... | |
medium_convergence_00522 | RB1 and STK4 both interact with a specific shared protein. Evidence regarding this shared protein states: 'We demonstrate that authentic or recombinant [the shared protein] and Rb interact directly and this requires a functional A/B pocket.' Which protein is encoded by this shared entity? | Nucleolar transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_00522","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RB1 and STK4 both interact with a specific shared protein. Evidence regarding this shared protein states: 'We demonstrate that authentic or recombinant [the ... | |
medium_convergence_00523 | Measles morbillivirus and Pegivirus C both upregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) reports a log2 fold change of approximately 2.69 and an adjusted p-value of 0.0045. Which disease is associated with this gene? | thymoma | Medium | convergence | {"qa_id":"medium_convergence_00523","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Pegivirus C both upregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) report... | |
medium_convergence_00525 | Zaire ebolavirus and Zika virus both downregulate a specific gene. Evidence for this shared target in a retinal pigment epithelium cell line (study GSE100839) reports a log2 fold change of approximately -1.54 and an adjusted p-value of 0.0051. Which protein is encoded by this gene? | ATP-binding cassette sub-family C member 3 | Medium | convergence | {"qa_id":"medium_convergence_00525","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Zika virus both downregulate a specific gene. Evidence for this shared target in a retinal pigment epithelium cell line (study GSE100839... | |
medium_convergence_00526 | GAS6 and AXL are both involved in more than one shared biological process. Evidence indicates that blocking the interaction between one of these proteins and its ligand using a soluble fusion protein, or inhibiting it with the vitamin K antagonist warfarin, significantly reduces the number and percentage of CD3(-)CD56(... | natural killer cell differentiation | Medium | convergence | {"qa_id":"medium_convergence_00526","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GAS6 and AXL are both involved in more than one shared biological process. Evidence indicates that blocking the interaction between one of these proteins and... |
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