qa_id stringlengths 24 32 | question stringlengths 156 1.14k | answer stringlengths 3 134 | level stringclasses 1
value | subtype stringclasses 3
values | source_medium_qa_id stringclasses 1
value | record_json stringlengths 13.6k 214k |
|---|---|---|---|---|---|---|
medium_convergence_03853 | EP300 and FOXK1 both interact with a shared protein. Evidence regarding one such shared entity states: 'Interestingly, full-length IRF-2 in TPA-treated U937 cells occurred as a complex with p300 as well as PCAF and was itself acetylated.' Which protein is connected to that entity through the 'encodes' relationship? | Interferon regulatory factor 2 | Medium | convergence | {"qa_id":"medium_convergence_03853","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and FOXK1 both interact with a shared protein. Evidence regarding one such shared entity states: 'Interestingly, full-length IRF-2 in TPA-treated U937 ... | |
medium_convergence_03854 | IPO5 and PRKN (Parkin) both interact with a shared protein entity. Evidence indicates that Parkin selectively binds to this entity, which is localized in the cytoplasmic filament of the nuclear pore complex and belongs to the small ubiquitin-related modifier E3 ligase family. Which disease is connected to this entity t... | lumbar disk degenerative disorder | Medium | convergence | {"qa_id":"medium_convergence_03854","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IPO5 and PRKN (Parkin) both interact with a shared protein entity. Evidence indicates that Parkin selectively binds to this entity, which is localized in the... | |
medium_convergence_03855 | DHCR24 and EP300 share a common interaction partner. Evidence regarding this shared entity states: 'The E region of RORalpha1 interacts with p300, a cofactor that functions as a coactivator in nuclear receptor and MyoD-mediated transactivation.' Which protein is connected to this shared entity through the 'encodes' rel... | Nuclear receptor ROR-alpha | Medium | convergence | {"qa_id":"medium_convergence_03855","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DHCR24 and EP300 share a common interaction partner. Evidence regarding this shared entity states: 'The E region of RORalpha1 interacts with p300, a cofactor... | |
medium_convergence_03856 | IL23A and IL21 are both involved in more than one shared biological process. One of these shared processes is linked to an entity described by the evidence: 'Consistent with this abnormality, we found increased IL-17 production by T cells from MS patients.' Which biological process is connected to that entity through t... | interleukin-17 production | Medium | convergence | {"qa_id":"medium_convergence_03856","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL23A and IL21 are both involved in more than one shared biological process. One of these shared processes is linked to an entity described by the evidence: ... | |
medium_convergence_03857 | RACK1 and MDM2 share multiple interaction partners. One such partner is a WD-repeat protein identified by its interaction with the cyclic AMP-specific phosphodiesterase (PDE4) isoform PDE4D5 in a yeast two-hybrid screen. Which cell type is this shared partner enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_03857","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RACK1 and MDM2 share multiple interaction partners. One such partner is a WD-repeat protein identified by its interaction with the cyclic AMP-specific phosph... | |
medium_convergence_03858 | NFKB1 and RELA each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Through in vitro binding experiments, a protein encoded by the shared gene was found to bind to several SWI/SNF complex subunits and also to the p52 NF-kappaB subunit through its nuclear localization sig... | Zinc finger protein ubi-d4 | Medium | convergence | {"qa_id":"medium_convergence_03858","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NFKB1 and RELA each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Through in vitro binding experiments, a ... | |
medium_convergence_03860 | EIF3M and EIF3B both interact with a common protein partner. Experimental evidence indicates that activating mTOR signaling with insulin increases the amount of this partner bound to eIF3 by up to five-fold. Which disease is associated with this protein partner as a biomarker? | myocardial ischemia | Medium | convergence | {"qa_id":"medium_convergence_03860","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3M and EIF3B both interact with a common protein partner. Experimental evidence indicates that activating mTOR signaling with insulin increases the amount... | |
medium_convergence_03861 | CD300A and FCGR2B are both involved in more than one shared biological process. Evidence regarding one of these shared processes indicates that co-ligation of the entity with the immunoreceptor tyrosine-based activating motif (ITAM) containing CD32a (FcgammaRIIa) activation receptor inhibited CD32a-mediated signaling, ... | neutrophil activation | Medium | convergence | {"qa_id":"medium_convergence_03861","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CD300A and FCGR2B are both involved in more than one shared biological process. Evidence regarding one of these shared processes indicates that co-ligation o... | |
medium_convergence_03862 | GH1 and GH2 each bind to more than one shared protein. Evidence concerning one of these shared proteins states: 'We show that GHRs occur as ∼500-kDa complexes that dimerize into active ∼900-kDa complexes upon GH binding.' Which disease is connected to that protein through a biomarker relationship? | autism spectrum disorder | Medium | convergence | {"qa_id":"medium_convergence_03862","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GH1 and GH2 each bind to more than one shared protein. Evidence concerning one of these shared proteins states: 'We show that GHRs occur as ∼500-kDa complexe... | |
medium_convergence_03863 | NEDD4L and UBAP1 both interact with multiple shared partners. One such partner is described in the following evidence: 'Here we show that ubiquitin associated protein 1 (UBAP1), a subunit of human ESCRT-I, coassembles in a stable 1:1:1:1 complex with Vps23/TSG101, VPS28, and VPS37.' Which protein is encoded by the gene... | Vacuolar protein sorting-associated protein 37A | Medium | convergence | {"qa_id":"medium_convergence_03863","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4L and UBAP1 both interact with multiple shared partners. One such partner is described in the following evidence: 'Here we show that ubiquitin associate... | |
medium_convergence_03864 | TRIM32 and TBK1 both interact with a shared protein. Evidence regarding one such shared partner states: 'Coimmunoprecipitation experiments indicated that a TRIM family protein interacted with IKKepsilon and TRAF family-associated NF-kappaB activator-binding kinase-1 as well as the two canonical IKK family members, IKKb... | mucosal-associated invariant T cell | Medium | convergence | {"qa_id":"medium_convergence_03864","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM32 and TBK1 both interact with a shared protein. Evidence regarding one such shared partner states: 'Coimmunoprecipitation experiments indicated that a T... | |
medium_convergence_03865 | PRKCI and RIPK1 both interact with a specific protein. Evidence indicates this protein is a phosphotyrosine-independent p56(lck) SH2-interacting protein, which interacts potently with the V1 domain of lambda/iotaPKC (PRKCI) and, with lower affinity, with zetaPKC. Which protein product is encoded by the gene correspondi... | Sequestosome-1 | Medium | convergence | {"qa_id":"medium_convergence_03865","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKCI and RIPK1 both interact with a specific protein. Evidence indicates this protein is a phosphotyrosine-independent p56(lck) SH2-interacting protein, whi... | |
medium_convergence_03866 | FANCE and BLM each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we associate the FA proteins with the Notch1 developmental pathway through a direct protein-protein interaction between the FA core complex and the hairy enhancer of split 1.' Which protein is connected t... | Transcription factor HES-1 | Medium | convergence | {"qa_id":"medium_convergence_03866","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCE and BLM each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we associate the FA proteins with the Not... | |
medium_convergence_03868 | DBF4 and CDC6 both physically interact with a specific protein component of the minichromosome maintenance (MCM) complex. Evidence indicates that the Cdc7/Dbf4 kinase complex physically interacts with and phosphorylates this MCM complex, specifically citing this protein alongside MCM4 and MCM6. Which disease is associa... | autosomal dominant nonsyndromic hearing loss 70 | Medium | convergence | {"qa_id":"medium_convergence_03868","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DBF4 and CDC6 both physically interact with a specific protein component of the minichromosome maintenance (MCM) complex. Evidence indicates that the Cdc7/Db... | |
medium_convergence_03869 | CBX3 and DNMT1 share common interaction partners. One such shared partner has been shown to interact with a heterochromatin protein 1 family member, leading to increased DNA methylation on DNA and chromatin templates in vitro. Which protein is encoded by the gene corresponding to this shared partner? | Chromobox protein homolog 5 | Medium | convergence | {"qa_id":"medium_convergence_03869","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and DNMT1 share common interaction partners. One such shared partner has been shown to interact with a heterochromatin protein 1 family member, leading ... | |
medium_convergence_03870 | IRF3 and ATG5 both interact with a common protein. Evidence regarding this shared partner states: 'Phosphorylated this protein and STING then bind to a positively charged surface of interferon regulatory factor 3 (IRF3) and thereby recruit IRF3 for its phosphorylation and activation by TBK1.' Which protein is encoded b... | Mitochondrial antiviral-signaling protein | Medium | convergence | {"qa_id":"medium_convergence_03870","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IRF3 and ATG5 both interact with a common protein. Evidence regarding this shared partner states: 'Phosphorylated this protein and STING then bind to a posit... | |
medium_convergence_03871 | HDAC2 and MBD3 each interact with more than one shared protein. Evidence concerning one such shared entity reports that in glutathione S-transferase pull-down assays, this entity is found associated with several known components of the MeCP1.NuRD complex, including HDAC1, HDAC2, MTA2, MBD2, RbAp46, and RbAp48, but MBD3... | Methyl-CpG-binding domain protein 3-like 1 | Medium | convergence | {"qa_id":"medium_convergence_03871","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC2 and MBD3 each interact with more than one shared protein. Evidence concerning one such shared entity reports that in glutathione S-transferase pull-dow... | |
medium_convergence_03872 | ESR1 and NR3C1 share a common interacting partner. Evidence regarding this partner states: 'In an in vitro glutathione-S-transferase pull-down assay, the partner interacted via its DNA-binding domain with the hinge regions of both GRalpha and its splicing variant GRbeta, whereas the partner formed a complex with GRalph... | COUP transcription factor 2 | Medium | convergence | {"qa_id":"medium_convergence_03872","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and NR3C1 share a common interacting partner. Evidence regarding this partner states: 'In an in vitro glutathione-S-transferase pull-down assay, the par... | |
medium_convergence_03873 | WDR5 and AKT1 share interaction partners. One such shared partner is part of a complex that directly phosphorylates Akt/PKB on Ser473 in vitro and facilitates Thr308 phosphorylation by PDK1. Which protein is encoded by this shared partner? | Rapamycin-insensitive companion of mTOR | Medium | convergence | {"qa_id":"medium_convergence_03873","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WDR5 and AKT1 share interaction partners. One such shared partner is part of a complex that directly phosphorylates Akt/PKB on Ser473 in vitro and facilitate... | |
medium_convergence_03874 | EIF3F and EIF3J both interact with a specific protein partner. Experimental evidence indicates that this partner interacts directly with eIF3c, eIF3g, and eIF3j via glutathione S-transferase pull-down assays. Which protein is encoded by the gene corresponding to this partner? | Eukaryotic translation initiation factor 3 subunit K | Medium | convergence | {"qa_id":"medium_convergence_03874","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3F and EIF3J both interact with a specific protein partner. Experimental evidence indicates that this partner interacts directly with eIF3c, eIF3g, and eI... | |
medium_convergence_03875 | Both Human immunodeficiency virus 1 and Dengue virus downregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) shows a log2 fold change of approximately -1.142 and an adjusted p-value of 0.003789. Which cellular component is this gene located in? | ubiquitin ligase complex | Medium | convergence | {"qa_id":"medium_convergence_03875","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus downregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) show... | |
medium_convergence_03876 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus upregulate a specific shared gene. In a study of lung fibroblast cell lines (GSE120891), this gene exhibited a log2 fold change of 1.721 and an adjusted p-value of 0.03813. Which biological process is this gene involved in? | negative regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_03876","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus upregulate a specific shared gene. In a study of lung fibroblast cell l... | |
medium_convergence_03877 | Clemastine and Morphine both interact with a specific drug. Evidence regarding this drug states: 'Among patients receiving prescription opioids, after controlling for all confounding factors, concomitant treatment with Z-drugs was associated with a substantial relative increase in the risk of overdose.' What disease is... | insomnia | Medium | convergence | {"qa_id":"medium_convergence_03877","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Clemastine and Morphine both interact with a specific drug. Evidence regarding this drug states: 'Among patients receiving prescription opioids, after contro... | |
medium_convergence_03878 | MAP4K1 and PPP2R1A both interact with a common protein partner. Evidence regarding one such partner states: 'We found that the catalytic subunit of protein phosphatase 4 interacted with HPK1 and that the proline-rich region of HPK1 was necessary and sufficient for this interaction.' Which protein is encoded by the gene... | Serine/threonine-protein phosphatase 4 catalytic subunit | Medium | convergence | {"qa_id":"medium_convergence_03878","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAP4K1 and PPP2R1A both interact with a common protein partner. Evidence regarding one such partner states: 'We found that the catalytic subunit of protein p... | |
medium_convergence_03879 | Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately 1.77 and an adjusted p-value of approximately 0.0031. Which protein does this gene product bind to? | TFB2M | Medium | convergence | {"qa_id":"medium_convergence_03879","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold... | |
medium_convergence_03880 | Both Influenza A virus and Zaire ebolavirus are reported to downregulate a specific host gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE106279) shows a log2 fold change of approximately -1.232 and an adjusted p-value of 0.006957. Which protein is encoded by this gene? | SAM and SH3 domain-containing protein 3 | Medium | convergence | {"qa_id":"medium_convergence_03880","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Zaire ebolavirus are reported to downregulate a specific host gene. Experimental data for this gene in a non-small cell lung adeno... | |
medium_convergence_03881 | ERCC1 and FANCD2 each interact with more than one shared protein partner. Evidence concerning one shared entity reports that co-immunoprecipitation with purified proteins indicates that this entity interacts with FANCD2 through its C-terminal amino acid 1001-1328 fragment. Which protein is encoded by this shared entity... | Fanconi anemia group I protein | Medium | convergence | {"qa_id":"medium_convergence_03881","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC1 and FANCD2 each interact with more than one shared protein partner. Evidence concerning one shared entity reports that co-immunoprecipitation with puri... | |
medium_convergence_03882 | PRKAA1 and ATG101 share a common binding partner. Evidence regarding this shared partner states: 'The AMPKbeta and AMPKgamma regulatory subunits were associated with AMPKalpha, but not with any of the AMPK-related kinases, explaining why AMP does not influence the activity of these enzymes.' Which protein is encoded by... | 5'-AMP-activated protein kinase subunit beta-1 | Medium | convergence | {"qa_id":"medium_convergence_03882","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKAA1 and ATG101 share a common binding partner. Evidence regarding this shared partner states: 'The AMPKbeta and AMPKgamma regulatory subunits were associa... | |
medium_convergence_03883 | MED19 and MED17 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'By comparing MudPIT data sets obtained from six independent Mediator preparations immunoaffinity purified through their Nut2 (MED10), Med25, Intersex, LCMR1 (MED19), AK007855 (MED28), or CRSP70 subunits,... | Mediator of RNA polymerase II transcription subunit 29 | Medium | convergence | {"qa_id":"medium_convergence_03883","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MED19 and MED17 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'By comparing MudPIT data sets obtained f... | |
medium_convergence_03884 | Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus both downregulate a specific gene. Evidence for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.13 and an adjusted p-value of 0.000465. Which cell type is this gene enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_03884","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus both downregulate a specific gene. Evidence for this gene in a melanoma ce... | |
medium_convergence_03885 | ESR1 and HDAC1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Interaction studies revealed unique epigenetic regulatory complexes associated with H3-K4 methylation in the testis, including the association of a histone demethylase and methyl-CpG-binding domain protein 2 ... | Lysine-specific histone demethylase 1A | Medium | convergence | {"qa_id":"medium_convergence_03885","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HDAC1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Interaction studies revealed unique epigeneti... | |
medium_convergence_03886 | EP300 and PRKN (PARK2) both interact with a shared protein. Evidence indicates that parkin interacts with and robustly ubiquitinates this shared entity in human neural cells. Which protein is encoded by this shared entity? | Vacuolar protein sorting-associated protein 35 | Medium | convergence | {"qa_id":"medium_convergence_03886","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and PRKN (PARK2) both interact with a shared protein. Evidence indicates that parkin interacts with and robustly ubiquitinates this shared entity in hu... | |
medium_convergence_03887 | PDS5B and POLH both interact with a shared protein. Evidence indicates that APRIN (PDS5B), a cohesion-associated protein, is identified as an associated protein for this shared entity. Which protein is encoded by this shared entity? | Breast cancer type 2 susceptibility protein | Medium | convergence | {"qa_id":"medium_convergence_03887","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PDS5B and POLH both interact with a shared protein. Evidence indicates that APRIN (PDS5B), a cohesion-associated protein, is identified as an associated prot... | |
medium_convergence_03888 | STRA13 and CENPS each share a binding partner. Biochemical evidence indicates that MHF1 and MHF2 assemble into a heterodimer that binds DNA and enhances the DNA branch migration activity of this shared entity. Which gene interacts with this shared entity? | TELO2 | Medium | convergence | {"qa_id":"medium_convergence_03888","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STRA13 and CENPS each share a binding partner. Biochemical evidence indicates that MHF1 and MHF2 assemble into a heterodimer that binds DNA and enhances the ... | |
medium_convergence_03889 | Both 'regulation of mast cell degranulation' and 'regulation of basophil degranulation' are subtypes of a shared biological process. Evidence for this shared process states: 'Any process that modulates the frequency, rate, or extent of mast cell degranulation.' Which biological process is directly regulated by this sha... | myeloid leukocyte mediated immunity | Medium | convergence | {"qa_id":"medium_convergence_03889","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both 'regulation of mast cell degranulation' and 'regulation of basophil degranulation' are subtypes of a shared biological process. Evidence for this shared... | |
medium_convergence_03890 | AMBRA1 and BECN1 share multiple binding partners. One such partner is a protein whose depletion leads to Nedd4-mediated proteasomal degradation of Beclin 1 via Lys11-linked polyubiquitin chains. Which disease is associated with this specific protein as a biomarker? | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_03890","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AMBRA1 and BECN1 share multiple binding partners. One such partner is a protein whose depletion leads to Nedd4-mediated proteasomal degradation of Beclin 1 v... | |
medium_convergence_03891 | Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of -1.671 and an adjusted p-value of 0.02565. Which disease is associated with this gene as a biomarker? | myelodysplastic syndrome | Medium | convergence | {"qa_id":"medium_convergence_03891","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indic... | |
medium_convergence_03892 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific host gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.261 and an adjusted p-value of 0.0007305. In w... | cytosol | Medium | convergence | {"qa_id":"medium_convergence_03892","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific host gene. Experimental data ... | |
medium_convergence_03893 | CHD4 and FBXO32 both interact with a common protein partner. Evidence regarding one such partner indicates that FBXO32 directly ubiquitinates this protein, a modification required for its stability and nuclear retention. Which protein is encoded by this ubiquitinated partner? | C-terminal-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03893","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and FBXO32 both interact with a common protein partner. Evidence regarding one such partner indicates that FBXO32 directly ubiquitinates this protein, a... | |
medium_convergence_03894 | HDAC2 and RB1 share multiple interacting partners. One such partner is characterized by evidence showing that pRB mutants lacking the LXCXE binding site are defective in binding to adenovirus E1A and human papillomavirus type 16 E7 protein, yet retain wild-type binding to E2F or DP and maintain interaction with a speci... | glaucoma | Medium | convergence | {"qa_id":"medium_convergence_03894","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC2 and RB1 share multiple interacting partners. One such partner is characterized by evidence showing that pRB mutants lacking the LXCXE binding site are ... | |
medium_convergence_03895 | DDX1 and RBMX both interact with a shared protein. Evidence identifies this shared protein as a deubiquitinase that acts as a central coordinator, interacting and co-localizing with RTCB and DDX1. Which disease is associated with this shared protein? | Leber congenital amaurosis 19 | Medium | convergence | {"qa_id":"medium_convergence_03895","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDX1 and RBMX both interact with a shared protein. Evidence identifies this shared protein as a deubiquitinase that acts as a central coordinator, interactin... | |
medium_convergence_03896 | Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene reports a log2 fold change of approximately 1.014 and an adjusted p-value of 0.006119. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_03896","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene reports a log2 fold change of approximately 1.014 and an adjuste... | |
medium_convergence_03898 | CENPS and BLM each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We also provide biochemical evidence that MHF1 and MHF2 assemble into a heterodimer that binds DNA and enhances the DNA branch migration activity of FANCM.' Which disease is connected to that entity through an... | fanconi anemia, complementation group 10 | Medium | convergence | {"qa_id":"medium_convergence_03898","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPS and BLM each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We also provide biochemical evidence that MHF1... | |
medium_convergence_03899 | CLTC and DNAJC6 share multiple binding partners. One of these shared partners is described by the evidence: 'The interaction with clathrin is direct and not mediated by epsin-bound AP-2.' Which disease is associated with this specific shared partner? | colon carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03899","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLTC and DNAJC6 share multiple binding partners. One of these shared partners is described by the evidence: 'The interaction with clathrin is direct and not ... | |
medium_convergence_03900 | POLM and PRKDC each interact with more than one shared gene. Evidence concerning one shared entity reports: 'The DNA-dependent protein kinase (DNA-PK) controls the repair of double-stranded DNA breaks in mammalian cells. The protein kinase subunit of DNA-PK (DNA-PKcs) is targeted to DNA breaks by association with the K... | alcohol abuse | Medium | convergence | {"qa_id":"medium_convergence_03900","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLM and PRKDC each interact with more than one shared gene. Evidence concerning one shared entity reports: 'The DNA-dependent protein kinase (DNA-PK) contro... | |
medium_convergence_03901 | RUNX1 and RUNX1T1 share multiple interacting partners. One such shared partner is characterized by evidence stating: 'Immunoprecipitation analysis indicates that this region is required for AML1-MTG8 to form a stable complex with a specific protein.' Which disease is associated with this specific shared partner? | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03901","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RUNX1 and RUNX1T1 share multiple interacting partners. One such shared partner is characterized by evidence stating: 'Immunoprecipitation analysis indicates ... | |
medium_convergence_03902 | H2AX and MYC both interact with a shared protein. Evidence indicates that upregulation of this shared protein increases its binding with c-Myc and activates c-Myc, which in turn induces the expression of CCND1/CDK4, promoting glioma cell temozolomide resistance and proliferation. Which protein is encoded by the gene co... | Nucleosome assembly protein 1-like 1 | Medium | convergence | {"qa_id":"medium_convergence_03902","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H2AX and MYC both interact with a shared protein. Evidence indicates that upregulation of this shared protein increases its binding with c-Myc and activates ... | |
medium_convergence_03903 | CFL1 and MYC both interact with a shared protein. Evidence regarding this shared protein indicates that vertebrate cofilin binds to it but does not increase yeast actin filament flexibility, nor does it sever them. Which protein is encoded by the gene corresponding to this shared entity? | Actin, alpha skeletal muscle | Medium | convergence | {"qa_id":"medium_convergence_03903","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CFL1 and MYC both interact with a shared protein. Evidence regarding this shared protein indicates that vertebrate cofilin binds to it but does not increase ... | |
medium_convergence_03904 | DHX9 and EEF1A1 both interact with a common protein partner. Experimental evidence indicates that this shared partner directly interacts with DHX9 via its Tudor domain. Which protein is encoded by this shared partner? | Tudor domain-containing protein 3 | Medium | convergence | {"qa_id":"medium_convergence_03904","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DHX9 and EEF1A1 both interact with a common protein partner. Experimental evidence indicates that this shared partner directly interacts with DHX9 via its Tu... | |
medium_convergence_03905 | PRMT5 and ESR1 share multiple interacting partners. One such shared partner exhibits an estrogen-responsive interaction with ERalpha. Which disease is associated with this specific shared partner via a biomarker relationship? | leukemia | Medium | convergence | {"qa_id":"medium_convergence_03905","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRMT5 and ESR1 share multiple interacting partners. One such shared partner exhibits an estrogen-responsive interaction with ERalpha. Which disease is associ... | |
medium_convergence_03907 | ALK and YWHAH share multiple protein interaction partners. One such shared partner was identified via LC/MS-MS analysis, which detected multiple proteins, including this shared entity and SHP2, and validated them as interactors of ALK in neuroblastoma (NB) cells. Which protein is encoded by the gene corresponding to th... | Inactive tyrosine-protein kinase PEAK1 | Medium | convergence | {"qa_id":"medium_convergence_03907","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALK and YWHAH share multiple protein interaction partners. One such shared partner was identified via LC/MS-MS analysis, which detected multiple proteins, in... | |
medium_convergence_03908 | RAC1 and TP53 share a common interacting partner. Evidence indicates that this shared partner forms a tricomplex with p53 and the E3 ubiquitin ligase HDM2 (also known as MDM2), a mechanism that prevents the ubiquitination and subsequent degradation of p53. Which protein is encoded by the gene corresponding to this shar... | Protein numb homolog | Medium | convergence | {"qa_id":"medium_convergence_03908","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAC1 and TP53 share a common interacting partner. Evidence indicates that this shared partner forms a tricomplex with p53 and the E3 ubiquitin ligase HDM2 (a... | |
medium_convergence_03909 | PRKN and USP7 share multiple interacting partners. One such partner is described in the following evidence: 'Here we show that [the interacting partner] directly interacts with the ubiquitin-specific protease USP7, that this interaction occurs predominantly on chromatin, and that [the interacting partner] can tether US... | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03909","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and USP7 share multiple interacting partners. One such partner is described in the following evidence: 'Here we show that [the interacting partner] dire... | |
medium_convergence_03910 | CTNNB1 and MYB both interact with a shared transcription factor. Evidence indicates that this shared factor forms a complex with β-catenin and another partner to bind the Nanog promoter, thereby maintaining the self-renewal of LACSLCs in an IGF-IR-dependent manner. Which protein is encoded by this shared transcription ... | POU domain, class 5, transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_03910","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and MYB both interact with a shared transcription factor. Evidence indicates that this shared factor forms a complex with β-catenin and another partne... | |
medium_convergence_03911 | NFIB and RELA each interact with more than one shared protein. Evidence concerning one of these shared entities indicates that the K310me1 modification on RelA was recognized by the ankyrin repeat of the histone methyltransferase EHMT1, which under basal conditions promoted a repressed chromatin state at RelA target ge... | Histone-lysine N-methyltransferase EHMT1 | Medium | convergence | {"qa_id":"medium_convergence_03911","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NFIB and RELA each interact with more than one shared protein. Evidence concerning one of these shared entities indicates that the K310me1 modification on Re... | |
medium_convergence_03912 | Both Human immunodeficiency virus 1 and Dengue virus are known to downregulate a specific gene. Experimental data for this gene, derived from macrophages in study GSE108897, reports a log2 fold change of approximately -1.61 and an adjusted p-value of 0.001954. Which disease is associated with this gene? | cardiomyopathy, familial hypertrophic, 28 | Medium | convergence | {"qa_id":"medium_convergence_03912","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are known to downregulate a specific gene. Experimental data for this gene, derived from macrophages in ... | |
medium_convergence_03913 | ARAF and BRAF both interact with a shared downstream effector in the MAPK signaling pathway. Evidence indicates that members of the Raf oncogene family encode serine/threonine protein kinases that activate mitogen-activated protein kinase kinases (MEKs) through direct interaction and phosphorylation. Which cell type is... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_03913","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARAF and BRAF both interact with a shared downstream effector in the MAPK signaling pathway. Evidence indicates that members of the Raf oncogene family encod... | |
medium_convergence_03915 | CCDC22 and CUL3 both interact with a specific shared protein. Evidence indicates that this shared protein binds to DAPK and Cullin 3 via its Kelch-repeat domain and BTB domain, respectively. Which disease is associated with this shared protein? | neurodevelopmental disorder with early-onset seizures, facial dysmorphism, and behavioral abnormalities | Medium | convergence | {"qa_id":"medium_convergence_03915","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCDC22 and CUL3 both interact with a specific shared protein. Evidence indicates that this shared protein binds to DAPK and Cullin 3 via its Kelch-repeat dom... | |
medium_convergence_03916 | CTBP1 and CTNNB1 share common interaction partners. One such partner is reported to form a repressor complex with CTBP1 in vivo. Which cell type is this specific partner enriched in? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | convergence | {"qa_id":"medium_convergence_03916","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and CTNNB1 share common interaction partners. One such partner is reported to form a repressor complex with CTBP1 in vivo. Which cell type is this spec... | |
medium_convergence_03917 | TGFBR1 and HMGA2 are both associated with multiple shared biological processes. A specific piece of evidence states: 'We previously reported that the high mobility group A2 (HMGA2) gene is required for TGF-beta to elicit EMT in mammary epithelial cells.' Based on this evidence, which biological process is directly link... | mesenchymal cell differentiation | Medium | convergence | {"qa_id":"medium_convergence_03917","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TGFBR1 and HMGA2 are both associated with multiple shared biological processes. A specific piece of evidence states: 'We previously reported that the high mo... | |
medium_convergence_03918 | MECP2 and RPA2 both interact with a specific shared protein. Evidence indicates that RPA physically interacts with this protein to form RPA-protein-H3.3 complexes and co-localizes with it and H3.3 at gene promoters and enhancers. Which protein is encoded by the gene corresponding to this shared entity? | Protein HIRA | Medium | convergence | {"qa_id":"medium_convergence_03918","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MECP2 and RPA2 both interact with a specific shared protein. Evidence indicates that RPA physically interacts with this protein to form RPA-protein-H3.3 comp... | |
medium_convergence_03919 | Calcitriol (topical) and Liothyronine both interact with a specific shared drug. Clinical evidence indicates that combining this shared drug (specifically in the context of hormone or estrogen replacement therapy) with calcitriol significantly increased bone mineral density at the femoral neck and spine. Which disease ... | postmenopausal osteoporosis | Medium | convergence | {"qa_id":"medium_convergence_03919","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Calcitriol (topical) and Liothyronine both interact with a specific shared drug. Clinical evidence indicates that combining this shared drug (specifically in... | |
medium_convergence_03920 | SP1 and NCOR1 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with co-repressor-histone deacetylase complexes, including BCoR, NCoR, and SMRT, via its POZ domain. Which protein is encoded by the gene corresponding to this shared entity? | Zinc finger and BTB domain-containing protein 5 | Medium | convergence | {"qa_id":"medium_convergence_03920","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SP1 and NCOR1 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with co-repressor-histone deacetylase compl... | |
medium_convergence_03921 | AKAP9 and PRKN (PARK2) share interaction partners. One such shared partner is CG-NAP, which contains two sets of putative RII (regulatory subunit of protein kinase A)-binding motifs and has been shown to tightly bind RIIalpha in HeLa cells. Which protein encodes this shared interaction partner? | cAMP-dependent protein kinase type II-alpha regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_03921","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP9 and PRKN (PARK2) share interaction partners. One such shared partner is CG-NAP, which contains two sets of putative RII (regulatory subunit of protein ... | |
medium_convergence_03922 | COL1A1 and ACTN4 share common interaction partners. One such partner is characterized by evidence stating that cultured cells synthesized proalpha2(I) chains that were slow to assemble with proalpha1(I) chains to form heterotrimers and were retained intracellularly. Which disease is associated with this specific shared... | dental fluorosis | Medium | convergence | {"qa_id":"medium_convergence_03922","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COL1A1 and ACTN4 share common interaction partners. One such partner is characterized by evidence stating that cultured cells synthesized proalpha2(I) chains... | |
medium_convergence_03923 | Desmopressin and Mefloquine both interact with a specific shared drug. Clinical evidence indicates that the administration of this shared drug in combination with Mefloquine resulted in a favorable outcome. Which disease is this shared drug indicated for? | major depressive disorder | Medium | convergence | {"qa_id":"medium_convergence_03923","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Desmopressin and Mefloquine both interact with a specific shared drug. Clinical evidence indicates that the administration of this shared drug in combination... | |
medium_convergence_03924 | Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately 1.184 and an adjusted p-value of 0.04824. Which disease is associated with this gene? | primordial dwarfism-immunodeficiency-lipodystrophy syndrome | Medium | convergence | {"qa_id":"medium_convergence_03924","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold... | |
medium_convergence_03925 | FAF1 and VCP share interaction partners. One such shared partner is characterized by evidence stating: 'The PUB domain mediated robust binding to the carboxy-terminus of p97, while the UBX domain did not contribute to p97 binding.' Which protein is encoded by this shared interaction partner? | UBX domain-containing protein 6 | Medium | convergence | {"qa_id":"medium_convergence_03925","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAF1 and VCP share interaction partners. One such shared partner is characterized by evidence stating: 'The PUB domain mediated robust binding to the carboxy... | |
medium_convergence_03926 | Interferon alfa-2b and Vinblastine both interact with a specific shared drug. Clinical evidence for this shared drug specifies a dosage of 1 mg/m2 intravenously, while Vinblastine is administered at 4 mg/m2 intravenously in the same context. Which disease is this shared drug indicated for? | Wilms tumor | Medium | convergence | {"qa_id":"medium_convergence_03926","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Interferon alfa-2b and Vinblastine both interact with a specific shared drug. Clinical evidence for this shared drug specifies a dosage of 1 mg/m2 intravenou... | |
medium_convergence_03927 | NBN and RAD1 both interact with a shared protein partner. Evidence indicates that mutations in the nibrin FHA and BRCT domains did not affect the interaction with Mre11 or the nuclear localization of the complex. Which cell type is enriched for this shared protein partner? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_03927","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NBN and RAD1 both interact with a shared protein partner. Evidence indicates that mutations in the nibrin FHA and BRCT domains did not affect the interaction... | |
medium_convergence_03928 | ESR1 and PPARG both interact with a specific shared protein. Evidence indicates that estrogen induces an interaction between this shared protein and ERalpha. Which protein is encoded by this shared entity? | Krueppel-like factor 5 | Medium | convergence | {"qa_id":"medium_convergence_03928","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and PPARG both interact with a specific shared protein. Evidence indicates that estrogen induces an interaction between this shared protein and ERalpha.... | |
medium_convergence_03929 | PDGFB and PDGFRA are both involved in more than one shared biological process. Evidence concerning one of these shared processes states: 'Checkerboard analysis showed that the promotion of migration at low concentrations was chemotactic in nature.' Which biological process is positively regulated by this shared entity? | chemotaxis | Medium | convergence | {"qa_id":"medium_convergence_03929","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PDGFB and PDGFRA are both involved in more than one shared biological process. Evidence concerning one of these shared processes states: 'Checkerboard analys... | |
medium_convergence_03930 | BRD4 and KMT2A share multiple interacting partners. One such shared partner is described by the following evidence: 'Here we show MLL interacts directly with the polymerase associated factor complex (PAFc) through sequences flanking the CxxC domain.' Which disease is associated with this specific shared entity? | pancreatic ductal adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_03930","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and KMT2A share multiple interacting partners. One such shared partner is described by the following evidence: 'Here we show MLL interacts directly with... | |
medium_convergence_03931 | USP25 and MYC both interact with a shared gene product. Evidence indicates that this shared entity interacts with three sarcomeric proteins: actin alpha-1, filamin C (FLNC), and myosin binding protein C1 (MyBPC1). These proteins are critically involved in muscle differentiation and maintenance and have been implicated ... | Actin, alpha skeletal muscle | Medium | convergence | {"qa_id":"medium_convergence_03931","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"USP25 and MYC both interact with a shared gene product. Evidence indicates that this shared entity interacts with three sarcomeric proteins: actin alpha-1, f... | |
medium_convergence_03932 | VPS29 and VPS26A each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Direct binding of the retromer component VPS29 to this entity could be titrated out by LC3, indicating a molecular switch between endosomes and autophagy.' Which protein is connected to that entity thr... | TBC1 domain family member 5 | Medium | convergence | {"qa_id":"medium_convergence_03932","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VPS29 and VPS26A each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Direct binding of the retromer compone... | |
medium_convergence_03933 | GNAO1 and ARRB2 both interact with a shared protein. Experimental evidence indicates that the carboxyl terminus and the third intracellular loop of the delta opioid receptor (DOR) are sufficient for binding to beta-arrestin 1 and 2. Which disease is associated with this shared protein as a biomarker? | gastric carcinoma | Medium | convergence | {"qa_id":"medium_convergence_03933","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAO1 and ARRB2 both interact with a shared protein. Experimental evidence indicates that the carboxyl terminus and the third intracellular loop of the delta... | |
medium_convergence_03934 | RNPS1 and ESR1 both interact with a common protein. Evidence indicates that RNPS1 inhibits the ubiquitin-mediated degradation of this shared protein by the E3 ubiquitin ligase ZSWIM6 through direct interaction, thereby promoting its high expression in head and neck squamous cell carcinoma (HNSCC). Which protein is enco... | RNA cytidine acetyltransferase | Medium | convergence | {"qa_id":"medium_convergence_03934","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RNPS1 and ESR1 both interact with a common protein. Evidence indicates that RNPS1 inhibits the ubiquitin-mediated degradation of this shared protein by the E... | |
medium_convergence_03935 | PEX10 and PEX2 each share a binding partner. Evidence concerning one of these shared partners reports that it interacted with PEX2 and the partner itself in vitro. Which cell type is that shared partner enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_03935","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PEX10 and PEX2 each share a binding partner. Evidence concerning one of these shared partners reports that it interacted with PEX2 and the partner itself in ... | |
medium_convergence_03936 | POLR2I and POLR2J both interact with a specific protein. Evidence indicates that the interaction between this protein and RNA Polymerase II is direct and mediated by the RPB1 subunit. Which protein product is encoded by this interacting partner? | ATP-dependent DNA helicase Q5 | Medium | convergence | {"qa_id":"medium_convergence_03936","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLR2I and POLR2J both interact with a specific protein. Evidence indicates that the interaction between this protein and RNA Polymerase II is direct and med... | |
medium_convergence_03937 | The biological processes 'negative regulation of antimicrobial humoral response' and 'negative regulation of innate immune response' both share a common parent process in the Gene Ontology hierarchy. Evidence for one of these shared parent processes states: 'Any process that stops, prevents, or reduces the frequency, r... | defense response | Medium | convergence | {"qa_id":"medium_convergence_03937","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'negative regulation of antimicrobial humoral response' and 'negative regulation of innate immune response' both share a common pare... | |
medium_convergence_03938 | Both Vaccinia virus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene, derived from a cervical adenocarcinoma cell line study (GSE11238), reports a log2 fold change of approximately -1.75 and an adjusted p-value of approximately 0.044. Which disease is genetically a... | common cold | Medium | convergence | {"qa_id":"medium_convergence_03938","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene, derived from a cervical adenocar... | |
medium_convergence_03939 | RUVBL2 and POLR2E both interact with a shared protein. Evidence indicates that Reptin, a highly conserved AAA+ ATPase involved in chromatin-remodeling complexes, associates with this shared protein, as demonstrated by immunoprecipitation and confocal microscopic analysis. Which protein is encoded by the gene correspond... | RNA polymerase II-associated protein 3 | Medium | convergence | {"qa_id":"medium_convergence_03939","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RUVBL2 and POLR2E both interact with a shared protein. Evidence indicates that Reptin, a highly conserved AAA+ ATPase involved in chromatin-remodeling comple... | |
medium_convergence_03940 | STUB1 and GLMN both interact with a shared protein. Evidence indicates that this shared protein specifically binds cellular inhibitor of apoptosis proteins 1 and 2, which are members of the inhibitor of apoptosis (IAP) family of RING-E3 ligases. This binding results in reduced E3 ligase activity and consequently inflam... | Baculoviral IAP repeat-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_03940","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and GLMN both interact with a shared protein. Evidence indicates that this shared protein specifically binds cellular inhibitor of apoptosis proteins 1... | |
medium_convergence_03941 | CDK2 and KAT5 both interact with a specific shared protein. Evidence indicates that this shared protein physically and functionally interacts with cyclin-dependent kinase 1 (Cdk1) and Cdk2. Which protein is encoded by this shared entity? | Hypoxia-inducible factor 1-alpha | Medium | convergence | {"qa_id":"medium_convergence_03941","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and KAT5 both interact with a specific shared protein. Evidence indicates that this shared protein physically and functionally interacts with cyclin-dep... | |
medium_convergence_03942 | Vaccinia virus and Cardiovirus A both upregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 3.21 and an adjusted p-value of approximately 1.72e-07. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_03942","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a lo... | |
medium_convergence_03943 | MAPK1 and MAPK3 both interact with a specific shared protein. Evidence regarding this shared protein states: 'The interaction between the shared protein and ERK1/2 was assessed by co-immunoprecipitation and GST pull-down assays in vivo and in vitro.' Which protein is encoded by this shared entity? | Leucine-rich repeat-containing protein 4 | Medium | convergence | {"qa_id":"medium_convergence_03943","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK1 and MAPK3 both interact with a specific shared protein. Evidence regarding this shared protein states: 'The interaction between the shared protein and ... | |
medium_convergence_03944 | Both Human alphaherpesvirus 1 and Dengue virus have been shown to upregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), the upregulation of this gene was associated with a log2 fold change of approximately 1.39 and an adjusted p-value of approximately 0.0098. Which protein is encoded ... | 7-dehydrocholesterol reductase | Medium | convergence | {"qa_id":"medium_convergence_03944","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Dengue virus have been shown to upregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), th... | |
medium_convergence_03945 | CHUK and CARD11 both interact with a specific shared protein. Evidence indicates that PKCδ inhibits the interaction between this shared protein and TRAF6, but does not disrupt the association of CARMA1 with PKCθ, Bcl10, or this shared protein. Which protein is encoded by the gene corresponding to this shared entity? | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Medium | convergence | {"qa_id":"medium_convergence_03945","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and CARD11 both interact with a specific shared protein. Evidence indicates that PKCδ inhibits the interaction between this shared protein and TRAF6, bu... | |
medium_convergence_03946 | PCNA and UBB each interact with more than one shared gene via physical binding. Evidence concerning one shared entity reports that Coimmunoprecipitation was performed to confirm the interaction between this entity and proliferating cell nuclear antigen (PCNA). Which gene is connected to that entity through binds? | WDR48 | Medium | convergence | {"qa_id":"medium_convergence_03946","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PCNA and UBB each interact with more than one shared gene via physical binding. Evidence concerning one shared entity reports that Coimmunoprecipitation was ... | |
medium_convergence_03947 | PSME3 and CSNK2A1 both interact with a shared protein. Evidence regarding this shared entity states: 'Among the novel CBX interacting partners, protein kinase 2 associates with all CBX-PRC1 protein complexes, whereas 14-3-3 proteins specifically bind to CBX4.' What molecular function is enabled by this shared entity? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_03947","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSME3 and CSNK2A1 both interact with a shared protein. Evidence regarding this shared entity states: 'Among the novel CBX interacting partners, protein kinas... | |
medium_convergence_03948 | ESR1 and HDAC3 share multiple binding partners. One such partner is described in literature as a novel nuclear protein, which specifically interacts in vitro with a domain of the estrogen receptor. Which disease is associated with this specific protein as a biomarker? | Malignant tumor of esophagus | Medium | convergence | {"qa_id":"medium_convergence_03948","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HDAC3 share multiple binding partners. One such partner is described in literature as a novel nuclear protein, which specifically interacts in vitro... | |
medium_convergence_03950 | CC2D2A and CDK1 both interact with a shared protein partner. Evidence for one such partner states: 'In addition, the proteins can physically interact in vitro, as shown by yeast two-hybrid and GST pull-down experiments.' Which protein is encoded by the gene corresponding to this specific shared partner? | Centrosomal protein of 290 kDa | Medium | convergence | {"qa_id":"medium_convergence_03950","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CC2D2A and CDK1 both interact with a shared protein partner. Evidence for one such partner states: 'In addition, the proteins can physically interact in vitr... | |
medium_convergence_03951 | CDC73 and CCNH each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we use a yeast two-hybrid screen to show that a new human cyclin (cyclin H) is a [shared kinase]-associated protein.' Which protein is encoded by the gene corresponding to that shared entity? | Cyclin-dependent kinase 7 | Medium | convergence | {"qa_id":"medium_convergence_03951","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC73 and CCNH each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we use a yeast two-hybrid screen to show... | |
medium_convergence_03952 | Human alphaherpesvirus 1 and Primate bocaparvovirus 1 are both reported to downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of approximately -1.337 and an adjusted p-value of 0.0113. Which protein is encoded by this gene? | Interleukin-1 alpha | Medium | convergence | {"qa_id":"medium_convergence_03952","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Primate bocaparvovirus 1 are both reported to downregulate a specific gene. Experimental data for this gene in a monocytic leuke... | |
medium_convergence_03953 | NFIC and TP53 share multiple interacting partners. One such shared partner forms a complex with p53 and SUV39H1, mediated by MDM2, which is capable of methylating H3-K9 in vitro and on p53 target promoters in vivo. Which protein is encoded by this shared partner? | Histone-lysine N-methyltransferase EHMT1 | Medium | convergence | {"qa_id":"medium_convergence_03953","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NFIC and TP53 share multiple interacting partners. One such shared partner forms a complex with p53 and SUV39H1, mediated by MDM2, which is capable of methyl... | |
medium_convergence_03954 | SLC22A1 and SLC22A3 both enable a shared molecular function. Evidence regarding one of these shared functions states: 'The plasma membrane monoamine transporter (PMAT) and organic cation transporter 3 (OCT3) are the two most prominent low-affinity, high-capacity (i.e., uptake(2)) transporters for endogenous biogenic am... | active transmembrane transporter activity | Medium | convergence | {"qa_id":"medium_convergence_03954","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SLC22A1 and SLC22A3 both enable a shared molecular function. Evidence regarding one of these shared functions states: 'The plasma membrane monoamine transpor... | |
medium_convergence_03955 | Both the regulation of T-helper 1 cell differentiation and the regulation of T-helper 17 cell differentiation are subtypes of a shared biological process. Evidence for one such shared entity states: 'Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation.' Which biological process i... | T-helper cell differentiation | Medium | convergence | {"qa_id":"medium_convergence_03955","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the regulation of T-helper 1 cell differentiation and the regulation of T-helper 17 cell differentiation are subtypes of a shared biological process. Ev... | |
medium_convergence_03957 | PRKN and SYK both interact with a shared protein. Evidence indicates that the recruitment of parkin is mediated through its binding to gamma-tubulin, which accumulates in the centrosome in response to misfolded proteins. Which protein is encoded by the gene corresponding to this shared entity? | Tubulin gamma-1 chain | Medium | convergence | {"qa_id":"medium_convergence_03957","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and SYK both interact with a shared protein. Evidence indicates that the recruitment of parkin is mediated through its binding to gamma-tubulin, which a... | |
medium_convergence_03958 | Erythromycin and Quinine both interact with a specific drug. Evidence regarding this drug states: 'Several possibly important drug-drug interactions have been identified with this drug, including ketoconazole, erythromycin and fluconazole, each of which increases this drug's mean C(max) by 9.52-, 2.28- and 1.88-fold, r... | overactive bladder | Medium | convergence | {"qa_id":"medium_convergence_03958","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Erythromycin and Quinine both interact with a specific drug. Evidence regarding this drug states: 'Several possibly important drug-drug interactions have bee... | |
medium_convergence_03959 | MAPK14 and MAPK1 both interact with a shared gene product. Evidence indicates that this shared entity is a novel ribosomal S6 kinase family member identified in a p38alphaMAPK-baited intracellular interaction screen. Which cellular component is this entity located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_03959","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK14 and MAPK1 both interact with a shared gene product. Evidence indicates that this shared entity is a novel ribosomal S6 kinase family member identified... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.