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medium_convergence_04299 | NFKB1 and BTRC both interact with a shared protein. Evidence regarding this shared protein states: 'Correspondingly, coimmunoprecipitation assays demonstrated that the NF-κB-inhibitory IκBα-p65-p50 complex was intact in VV811-infected cells.' Which disease is associated with this protein via a protective relationship? | nephritis | Medium | convergence | {"qa_id":"medium_convergence_04299","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NFKB1 and BTRC both interact with a shared protein. Evidence regarding this shared protein states: 'Correspondingly, coimmunoprecipitation assays demonstrate... | |
medium_convergence_04300 | MYC and SNAI2 both interact with a specific protein. Evidence indicates that the c-Box and ubiquitin binding domain (UBA) regions of this protein bind to c-Myc and inhibit its K48-linked polyubiquitination. Which protein is encoded by the gene corresponding to this interacting partner? | Ubiquitin carboxyl-terminal hydrolase 5 | Medium | convergence | {"qa_id":"medium_convergence_04300","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and SNAI2 both interact with a specific protein. Evidence indicates that the c-Box and ubiquitin binding domain (UBA) regions of this protein bind to c-M... | |
medium_convergence_04301 | EGFR and GRAP2 share multiple binding partners. One shared partner is distinguished by evidence stating: 'Consistently, epidermal growth factor receptor and platelet-derived growth factor receptor preferentially interact with the beta isoform of Nck over the alpha isoform in vitro.' Which protein is encoded by the gene... | Cytoplasmic protein NCK2 | Medium | convergence | {"qa_id":"medium_convergence_04301","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and GRAP2 share multiple binding partners. One shared partner is distinguished by evidence stating: 'Consistently, epidermal growth factor receptor and ... | |
medium_convergence_04302 | Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -2.697 and an adjusted p-value of 0.01205. Which disease is associated with genomic alterations in this gene? | systemic lupus erythematosus | Medium | convergence | {"qa_id":"medium_convergence_04302","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) r... | |
medium_convergence_04303 | MAPK1 and MAPK9 share a common interaction partner. Experimental evidence indicates that activated P-ERK1/2 binds to and phosphorylates this shared entity at serine residue 216 following p14ARF expression. Which disease is associated with this entity? | leukemia | Medium | convergence | {"qa_id":"medium_convergence_04303","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK1 and MAPK9 share a common interaction partner. Experimental evidence indicates that activated P-ERK1/2 binds to and phosphorylates this shared entity at... | |
medium_convergence_04304 | G3BP1 and ESCO2 both interact with a specific protein component of the MCM complex. Evidence indicates that ESCO2, but not ESCO1, interacts with the MCM complex through a unique ESCO2 domain. Which protein is encoded by the gene corresponding to this shared interaction partner? | DNA replication licensing factor MCM7 | Medium | convergence | {"qa_id":"medium_convergence_04304","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"G3BP1 and ESCO2 both interact with a specific protein component of the MCM complex. Evidence indicates that ESCO2, but not ESCO1, interacts with the MCM comp... | |
medium_convergence_04306 | HRAS and MAPK3 share a common interaction partner. Evidence indicates that the transforming activity of Ras correlates most strongly with the ability of the encoded protein to interact with this shared partner. Which cell type is enriched for this shared interaction partner? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_04306","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HRAS and MAPK3 share a common interaction partner. Evidence indicates that the transforming activity of Ras correlates most strongly with the ability of the ... | |
medium_convergence_04307 | Dengue virus and Human gammaherpesvirus 8 both upregulate a specific gene. In a study using a hepatoma cell line (GSE110512), the upregulation of this gene by Dengue virus was associated with a log2 fold change of approximately 1.55 and an adjusted p-value of 0.0357. Which protein is encoded by this gene? | Krueppel-like factor 4 | Medium | convergence | {"qa_id":"medium_convergence_04307","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Human gammaherpesvirus 8 both upregulate a specific gene. In a study using a hepatoma cell line (GSE110512), the upregulation of this gene b... | |
medium_convergence_04308 | IL6ST and OSM each interact with more than one shared receptor partner. Evidence concerning one shared entity reports that mutation of a specific cysteine in D5 of gp130 (C458A) leads to constitutive heterodimerization with this entity and increased sensitivity towards LIF stimulation. Which protein is connected to tha... | Leukemia inhibitory factor receptor | Medium | convergence | {"qa_id":"medium_convergence_04308","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL6ST and OSM each interact with more than one shared receptor partner. Evidence concerning one shared entity reports that mutation of a specific cysteine in... | |
medium_convergence_04309 | Fibrinogen (FGB) and Interleukin-1 receptor-associated kinase 2 (IRAK2) both interact with a common protein partner. Evidence indicates that this shared partner associates with IRAK2 via its TIR domain. Which protein is encoded by the gene corresponding to this shared partner? | Toll/interleukin-1 receptor domain-containing adapter protein | Medium | convergence | {"qa_id":"medium_convergence_04309","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Fibrinogen (FGB) and Interleukin-1 receptor-associated kinase 2 (IRAK2) both interact with a common protein partner. Evidence indicates that this shared part... | |
medium_convergence_04310 | AP3S1 and PRKN (PARK2) share common interaction partners. One such shared partner is described in a study reporting an interdomain interaction involving the ear domain of the delta subunit and the sigma3 subunit of AP-3. Which protein encodes this specific shared interaction partner? | AP-3 complex subunit delta-1 | Medium | convergence | {"qa_id":"medium_convergence_04310","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP3S1 and PRKN (PARK2) share common interaction partners. One such shared partner is described in a study reporting an interdomain interaction involving the ... | |
medium_convergence_04312 | Somatotropin and Methotrexate both interact with a specific drug. Evidence regarding this drug states: 'This case highlights the potential impact of drug interactions involving this drug and known OAT3 perpetrators on the pharmacokinetics of rivaroxaban and other OAT3 substrates, particularly those of low therapeutic i... | extensively drug-resistant tuberculosis | Medium | convergence | {"qa_id":"medium_convergence_04312","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Somatotropin and Methotrexate both interact with a specific drug. Evidence regarding this drug states: 'This case highlights the potential impact of drug int... | |
medium_convergence_04313 | The M11 retinal ganglion cell and the diffuse bistratified amacrine cell share synaptic input/output regions. One shared anatomical entity is characterized by evidence describing a bistratified ganglion cell with small, dense dendritic fields that terminate in S1 and S3. Which anatomical structure is this specific enti... | sublaminar layers S1 or S2 | Medium | convergence | {"qa_id":"medium_convergence_04313","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The M11 retinal ganglion cell and the diffuse bistratified amacrine cell share synaptic input/output regions. One shared anatomical entity is characterized b... | |
medium_convergence_04315 | EIF3E and EIF3C both interact with a shared protein partner. Evidence regarding one such partner states: 'A direct protein-protein interaction occurs between [the protein encoded by the shared partner] and Int-6, but the analysis of different mutants of [the protein encoded by the shared partner] indicated that a large... | Eukaryotic translation initiation factor 3 subunit L | Medium | convergence | {"qa_id":"medium_convergence_04315","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3E and EIF3C both interact with a shared protein partner. Evidence regarding one such partner states: 'A direct protein-protein interaction occurs between... | |
medium_convergence_04317 | In a study of monocytic leukemia cell lines (GSE114966), both Human alphaherpesvirus 1 and Human mastadenovirus C were found to upregulate a specific gene. For one such shared target, the reported log2 fold change was approximately 1.39 and the adjusted p-value was 0.006988. Which protein is encoded by this gene? | Pro-adrenomedullin | Medium | convergence | {"qa_id":"medium_convergence_04317","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"In a study of monocytic leukemia cell lines (GSE114966), both Human alphaherpesvirus 1 and Human mastadenovirus C were found to upregulate a specific gene. F... | |
medium_convergence_04318 | CSNK2A2 and KMT2A share multiple interacting partners. One such shared partner is described as a chromatin-modifying enzyme that interacts, colocalizes, and functionally cooperates with both CSNK2A2 and KMT2A, and is recruited to multiple HOX promoters. Which protein is encoded by this shared partner? | Histone acetyltransferase KAT6A | Medium | convergence | {"qa_id":"medium_convergence_04318","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A2 and KMT2A share multiple interacting partners. One such shared partner is described as a chromatin-modifying enzyme that interacts, colocalizes, and ... | |
medium_convergence_04319 | Vaccinia virus and Cardiovirus A both upregulate a specific gene in cervical adenocarcinoma cells. Experimental data for this gene shows a log2 fold change of 5.759 and an adjusted p-value of 1.996e-05. Which protein is encoded by this gene? | Matrilysin | Medium | convergence | {"qa_id":"medium_convergence_04319","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene in cervical adenocarcinoma cells. Experimental data for this gene shows a log2 fold change o... | |
medium_convergence_04320 | AKAP13 and PPP1CA both interact with a specific protein. Evidence regarding this shared interaction partner states: 'Both Ht 31 (493-515) peptide and its parent protein bind RII alpha or the type II PKA holoenzyme with high affinity.' Which protein is encoded by the gene corresponding to this shared interaction partner... | cAMP-dependent protein kinase type II-alpha regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_04320","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP13 and PPP1CA both interact with a specific protein. Evidence regarding this shared interaction partner states: 'Both Ht 31 (493-515) peptide and its par... | |
medium_convergence_04322 | CASP8 and CASP10 both interact with a specific shared protein. Contextual evidence indicates that a specific apoptosis regulator, while structurally similar to Mch4 and Mch5, lacks caspase activity but specifically interacts with FADD, Mch4, and Mch5. Based on this interaction profile, which protein is the shared entit... | CASP8 and FADD-like apoptosis regulator | Medium | convergence | {"qa_id":"medium_convergence_04322","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CASP8 and CASP10 both interact with a specific shared protein. Contextual evidence indicates that a specific apoptosis regulator, while structurally similar ... | |
medium_convergence_04323 | CBFB and LDB1 both interact with a specific transcription factor. Evidence regarding this factor states: 'In addition to known TAL-1 partners, GATA-1, E2A, HEB, LMO2 and Ldb1, we identify the ETO2 repressor as a novel component recruited to TAL-1 complexes through interaction with E2A/HEB.' Which disease is associated ... | leukemia, acute lymphocytic, susceptibility to, 1 | Medium | convergence | {"qa_id":"medium_convergence_04323","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBFB and LDB1 both interact with a specific transcription factor. Evidence regarding this factor states: 'In addition to known TAL-1 partners, GATA-1, E2A, H... | |
medium_convergence_04324 | HDAC1 and LEF1 both interact with a specific transcriptional corepressor. Evidence indicates that interactions between Groucho and this corepressor are enhanced by the sumoylation of Groucho, a process mediated by the SUMO-interaction motif of the corepressor. Which disease is associated with this corepressor? | fibrosarcoma | Medium | convergence | {"qa_id":"medium_convergence_04324","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and LEF1 both interact with a specific transcriptional corepressor. Evidence indicates that interactions between Groucho and this corepressor are enhan... | |
medium_convergence_04326 | BRAF and KSR1 both interact with a specific shared protein. Biochemical evidence indicates that residues Raf-Arg59 and Raf-Arg67 from the Raf RBD domain interact with Ras-Glu37, which is located in the Ras effector region. Which protein product is encoded by this shared interacting partner? | GTPase NRas | Medium | convergence | {"qa_id":"medium_convergence_04326","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRAF and KSR1 both interact with a specific shared protein. Biochemical evidence indicates that residues Raf-Arg59 and Raf-Arg67 from the Raf RBD domain inte... | |
medium_convergence_04327 | NPY1R and NPY2R both enable a shared molecular function. One piece of evidence regarding this shared function states: 'When expressed in Chinese hamster ovary (CHO) or human embryonic kidney (293) cells, the receptor exhibits the characteristic ligand specificity of a Y1 type of NPY receptor.' What is the parent molecu... | G protein-coupled peptide receptor activity | Medium | convergence | {"qa_id":"medium_convergence_04327","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NPY1R and NPY2R both enable a shared molecular function. One piece of evidence regarding this shared function states: 'When expressed in Chinese hamster ovar... | |
medium_convergence_04328 | BUB1 and BUB1B both interact with a shared protein that is a core component of the mitotic checkpoint complex (MCC), which consists of hBUBR1, this protein, CDC20, and MAD2 in near equal stoichiometry. Which cellular component is this shared protein located in? | kinetochore | Medium | convergence | {"qa_id":"medium_convergence_04328","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BUB1 and BUB1B both interact with a shared protein that is a core component of the mitotic checkpoint complex (MCC), which consists of hBUBR1, this protein, ... | |
medium_convergence_04329 | Human immunodeficiency virus 1 and Human mastadenovirus C both upregulate a specific gene. Evidence for this gene reports a log2 fold change of 1.136 and an adjusted p-value of 0.0122. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_04329","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human immunodeficiency virus 1 and Human mastadenovirus C both upregulate a specific gene. Evidence for this gene reports a log2 fold change of 1.136 and an ... | |
medium_convergence_04330 | Both Influenza A virus and Orthohepevirus A are known to upregulate a specific gene. Experimental data from a study on non-small cell lung adenocarcinoma cell lines (GSE147507) indicates that for one such shared target, the log2 fold change is 1.456 and the adjusted p-value is 1.014e-10. Which disease is associated wit... | glioma | Medium | convergence | {"qa_id":"medium_convergence_04330","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Orthohepevirus A are known to upregulate a specific gene. Experimental data from a study on non-small cell lung adenocarcinoma cel... | |
medium_convergence_04331 | DYRK1A and MYO6 share a common interaction partner. Experimental evidence indicates that the MVI cargo domain binds to the C-terminal M2 and DHR2 domains of this shared partner via its RRL motif, and this interaction has been observed in multiple cell lines. Which protein is encoded by this shared interaction partner? | Dedicator of cytokinesis protein 7 | Medium | convergence | {"qa_id":"medium_convergence_04331","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DYRK1A and MYO6 share a common interaction partner. Experimental evidence indicates that the MVI cargo domain binds to the C-terminal M2 and DHR2 domains of ... | |
medium_convergence_04332 | EP300 and PRKN each interact with more than one shared gene. Evidence concerning one shared entity reports: 'In this report, histone acetyltransferase p300 enhanced the entity-induced transactivation and interacted with the entity both in vitro and in the entity-transformed chicken spleen cells and the B-lymphoma cell ... | SKP1 | Medium | convergence | {"qa_id":"medium_convergence_04332","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and PRKN each interact with more than one shared gene. Evidence concerning one shared entity reports: 'In this report, histone acetyltransferase p300 e... | |
medium_convergence_04334 | MECP2 and FBXW7 share a common interacting partner. Evidence regarding this partner states: 'Whereas the N-terminal region of this helicase interacts with c-Myc, the rest of the helicase interacts with the c-Myc E3 ligase Fbw7.' Which cell type is this entity enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_04334","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MECP2 and FBXW7 share a common interacting partner. Evidence regarding this partner states: 'Whereas the N-terminal region of this helicase interacts with c-... | |
medium_convergence_04336 | MAPT and TP53 share multiple interacting partners. One such partner was identified as a mitochondrial p53-interacting protein using immunoprecipitation from purified mitochondria followed by mass spectrometry. Which disease is associated with this specific protein through genomic alterations? | ovarian cancer | Medium | convergence | {"qa_id":"medium_convergence_04336","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPT and TP53 share multiple interacting partners. One such partner was identified as a mitochondrial p53-interacting protein using immunoprecipitation from ... | |
medium_convergence_04337 | COPA and COG7 both interact with a shared protein partner. Experimental evidence, including immunoprecipitation and yeast two-hybrid analysis within a complete COP screen, demonstrates physical interactions between alpha- and epsilon-COPs, as well as between beta- and delta-COPs. Which molecular function is enabled by ... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_04337","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPA and COG7 both interact with a shared protein partner. Experimental evidence, including immunoprecipitation and yeast two-hybrid analysis within a comple... | |
medium_convergence_04340 | Phenytoin and Rifabutin both interact with a specific drug. Evidence indicates that the bioavailability of this drug is markedly reduced when administered jointly with antiepileptics or corticosteroids, specifically carbamazepine, phenytoin, or dexamethasone. Which disease is this drug indicated for? | schistosomiasis | Medium | convergence | {"qa_id":"medium_convergence_04340","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Phenytoin and Rifabutin both interact with a specific drug. Evidence indicates that the bioavailability of this drug is markedly reduced when administered jo... | |
medium_convergence_04341 | CREBBP and PML both interact with a shared protein. Evidence regarding this shared protein states: 'Nuclear magnetic resonance (NMR) spectroscopy combined with cross-linking experiments and competition-binding assays showed that the fully disordered isolated ID3 transiently interacts with an IDR of this shared protein ... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_04341","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and PML both interact with a shared protein. Evidence regarding this shared protein states: 'Nuclear magnetic resonance (NMR) spectroscopy combined wi... | |
medium_convergence_04342 | OPTN and HSPA8 share multiple interacting partners. One such partner is identified in the following evidence: 'Here, we identified optineurin (OPTN) as an [entity]-binding protein by yeast two-hybrid screening using [entity] as bait.' Which cell type is enriched for this specific interacting entity? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_04342","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OPTN and HSPA8 share multiple interacting partners. One such partner is identified in the following evidence: 'Here, we identified optineurin (OPTN) as an [e... | |
medium_convergence_04343 | ERBB2 and ABL1 share common interacting partners. One such partner is described in a study stating: 'In this study, we show that Abl kinase SH2 domains bind directly to Her-2, and like PDGFR-beta, Her-2 directly phosphorylates c-Abl.' Which disease is associated with this specific interacting partner via genomic altera... | MELAS syndrome | Medium | convergence | {"qa_id":"medium_convergence_04343","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and ABL1 share common interacting partners. One such partner is described in a study stating: 'In this study, we show that Abl kinase SH2 domains bind ... | |
medium_convergence_04344 | EIF3J and EIF2S2 share multiple binding partners. One such partner is identified by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which cellular component is this specific partner located in? | eukaryotic translation initiation factor 3 complex | Medium | convergence | {"qa_id":"medium_convergence_04344","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3J and EIF2S2 share multiple binding partners. One such partner is identified by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 ... | |
medium_convergence_04345 | IFT122 and TULP3 are both involved in more than one shared biological process. Evidence indicates that one of these shared processes involves the promotion of trafficking for a subset of G protein-coupled receptors (GPCRs), but not Smoothened, to cilia, mediated by TULP3 and IFT-A. Which cellular component is the targe... | non-motile cilium | Medium | convergence | {"qa_id":"medium_convergence_04345","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IFT122 and TULP3 are both involved in more than one shared biological process. Evidence indicates that one of these shared processes involves the promotion o... | |
medium_convergence_04346 | Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) reports a log2 fold change of -1.168 and an adjusted p-value of 0.03503. Which disease is linked to this gene v... | hemochromatosis type 4 | Medium | convergence | {"qa_id":"medium_convergence_04346","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data ... | |
medium_convergence_04347 | FANCD2 and FAN1 both interact with a shared protein partner. Evidence indicates that a direct interaction between this shared partner and FANCD2 was demonstrated in the yeast two-hybrid system. Which protein is encoded by this shared partner? | Fanconi anemia group E protein | Medium | convergence | {"qa_id":"medium_convergence_04347","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCD2 and FAN1 both interact with a shared protein partner. Evidence indicates that a direct interaction between this shared partner and FANCD2 was demonstr... | |
medium_convergence_04348 | The facial vein and the canal of Schlemm are both classified as types of a specific anatomical structure. Evidence regarding one of these structures states: 'The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a sm... | systemic vein | Medium | convergence | {"qa_id":"medium_convergence_04348","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The facial vein and the canal of Schlemm are both classified as types of a specific anatomical structure. Evidence regarding one of these structures states: ... | |
medium_convergence_04349 | SIN3A and HDAC2 share interaction partners. One such shared partner is a native subunit of a repressive mSin3a-HDAC1 histone deacetylase complex that binds with high affinity to trimethylated species. Which protein is encoded by this shared partner? | Inhibitor of growth protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04349","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and HDAC2 share interaction partners. One such shared partner is a native subunit of a repressive mSin3a-HDAC1 histone deacetylase complex that binds w... | |
medium_convergence_04350 | PARP1 and EP300 share multiple interacting partners. One such partner is described in evidence stating: 'Mechanistic analysis further showed that it specifically interacts with poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme important in DNA repair and apoptosis.' Which cell type is this specific partner enric... | basophil | Medium | convergence | {"qa_id":"medium_convergence_04350","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and EP300 share multiple interacting partners. One such partner is described in evidence stating: 'Mechanistic analysis further showed that it specific... | |
medium_convergence_04351 | Cyproheptadine and Dronabinol both interact with a specific shared drug. Evidence indicates that while p-Chlorophenylalanine and methergoline had no effect, this shared drug enhanced the anticonvulsive action of most benzodiazepines tested. Which disease is this shared drug indicated for? | anxiety | Medium | convergence | {"qa_id":"medium_convergence_04351","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cyproheptadine and Dronabinol both interact with a specific shared drug. Evidence indicates that while p-Chlorophenylalanine and methergoline had no effect, ... | |
medium_convergence_04352 | TOPBP1 and CUL3 both interact with a shared protein. Evidence regarding one such shared partner states: 'In this study, we found, by mass spectrometry, that Cullin-3 (CUL3)/KCTD10 ubiquitin (Ub) ligase forms a complex with [the shared protein].' Which protein is encoded by this shared partner? | Eukaryotic translation initiation factor 3 subunit D | Medium | convergence | {"qa_id":"medium_convergence_04352","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and CUL3 both interact with a shared protein. Evidence regarding one such shared partner states: 'In this study, we found, by mass spectrometry, that ... | |
medium_convergence_04353 | C1D and NCBP2 each interact with more than one shared protein partner. Evidence concerning one specific shared partner indicates that this protein binds the cap-binding complex (CBC), which is universally present on capped RNAs, and also associates with the nuclear exosome targeting (NEXT) complex, thereby linking to R... | RNA destabilization | Medium | convergence | {"qa_id":"medium_convergence_04353","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"C1D and NCBP2 each interact with more than one shared protein partner. Evidence concerning one specific shared partner indicates that this protein binds the ... | |
medium_convergence_04354 | HNRNPH1 and HSP90AA1 share multiple interaction partners. One such shared partner is known to interact with and be stabilized by HSP90AA1. Which protein is encoded by this specific shared partner? | Zinc finger and BTB domain-containing protein 7A | Medium | convergence | {"qa_id":"medium_convergence_04354","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HNRNPH1 and HSP90AA1 share multiple interaction partners. One such shared partner is known to interact with and be stabilized by HSP90AA1. Which protein is e... | |
medium_convergence_04355 | NCOR1 and NCOR2 each interact with multiple shared partners. One such partner is described in evidence stating: 'Here we show that the pregnane X receptor interacts more strongly with SMRTalpha than with SMRTtau both in vitro and in vivo.' Which protein is encoded by the gene corresponding to this shared partner? | Nuclear receptor subfamily 1 group I member 2 | Medium | convergence | {"qa_id":"medium_convergence_04355","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCOR1 and NCOR2 each interact with multiple shared partners. One such partner is described in evidence stating: 'Here we show that the pregnane X receptor in... | |
medium_convergence_04356 | DCAF7 and CBX3 both interact with a shared protein. Evidence regarding one such shared interactor states: 'Here, we identify the evolutionary conserved WD40-repeat protein Han11 as an interactor of the kinase [shared interactor].' Which cell type is this specific kinase enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_04356","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCAF7 and CBX3 both interact with a shared protein. Evidence regarding one such shared interactor states: 'Here, we identify the evolutionary conserved WD40-... | |
medium_convergence_04357 | FANCC and FAAP24 both interact with a shared protein. Evidence indicates that this shared protein is a component of a nuclear protein complex containing FANCA and the shared protein itself. Which protein is encoded by the gene corresponding to this shared entity? | Fanconi anemia group G protein | Medium | convergence | {"qa_id":"medium_convergence_04357","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCC and FAAP24 both interact with a shared protein. Evidence indicates that this shared protein is a component of a nuclear protein complex containing FANC... | |
medium_convergence_04358 | IL1R1 and IL33 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'When human embryonic kidney cells (cell line 293) over-expressing IL-1RI or HeLa cells were exposed to IL-1, a kinase rapidly associated with the IL-1RI complex and was phosphorylated.' Which protein is conne... | Interleukin-1 receptor-associated kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_04358","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL1R1 and IL33 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'When human embryonic kidney cells (cell line ... | |
medium_convergence_04360 | Both Human mastadenovirus C and Zika virus are known to upregulate a specific shared gene. Experimental data for this gene, derived from a study on lung fibroblast cell lines (GSE120891), reports a log2 fold change of approximately 1.418 and an adjusted p-value of approximately 0.0459. Which cell type is this gene enri... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_04360","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Zika virus are known to upregulate a specific shared gene. Experimental data for this gene, derived from a study on lung fibr... | |
medium_convergence_04361 | TRIM28 and FANCD2 share common interaction partners. One such shared partner is supported by evidence stating: 'We found that FANCD2 can interact directly with minichromosome maintenance (MCM) proteins.' Which protein is encoded by this shared interaction partner? | DNA replication licensing factor MCM4 | Medium | convergence | {"qa_id":"medium_convergence_04361","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and FANCD2 share common interaction partners. One such shared partner is supported by evidence stating: 'We found that FANCD2 can interact directly wi... | |
medium_convergence_04362 | Cerebellar Purkinje cell differentiation and Lugaro cell differentiation are both specific types of a broader biological process. Evidence regarding one of these specific processes describes it as the acquisition of specialized structural and functional features by neuroblasts to become mature cerebellar Purkinje cells... | hindbrain development | Medium | convergence | {"qa_id":"medium_convergence_04362","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cerebellar Purkinje cell differentiation and Lugaro cell differentiation are both specific types of a broader biological process. Evidence regarding one of t... | |
medium_convergence_04363 | CTBP1 and CTBP2 both interact with a specific transcription factor. Experimental evidence indicates that screening for proteins interacting with subdomains 1 and 2 of this factor using yeast two-hybrid analysis revealed that subdomain 2 binds to C-terminal binding protein 1. This interaction allows for synergistic tran... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_04363","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and CTBP2 both interact with a specific transcription factor. Experimental evidence indicates that screening for proteins interacting with subdomains 1... | |
medium_convergence_04365 | Both Human alphaherpesvirus 1 and Hepacivirus C are reported to downregulate a specific host gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of approximately -1.25 and an adjusted p-value of 0.004664. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_04365","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Hepacivirus C are reported to downregulate a specific host gene. Experimental data for this gene in a monocytic leukemia ce... | |
medium_convergence_04366 | ATM and RAD51 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In assays using purified components, phosphorylation of RAD51 by c-Abl enhances complex formation between RAD51 and this shared entity, which cooperates with RAD51 in recombination and repair.' Which disease i... | cervical squamous cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04366","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and RAD51 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In assays using purified components, phosphory... | |
medium_convergence_04367 | PRKN and UBA6 each interact with more than one shared gene product. Evidence concerning one shared entity reports that Parkin binds to the E2 enzyme of FAT10 (a specific ubiquitin-like modifier conjugating enzyme), auto-FAT10ylates itself, and facilitates FAT10ylation of the Parkin substrate Mitofusin2 in vitro and in ... | Ubiquitin-conjugating enzyme E2 Z | Medium | convergence | {"qa_id":"medium_convergence_04367","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and UBA6 each interact with more than one shared gene product. Evidence concerning one shared entity reports that Parkin binds to the E2 enzyme of FAT10... | |
medium_convergence_04368 | Betaxolol and Propranolol both interact with a specific shared drug. Evidence indicates that Propranolol significantly shifted the dose-response curve of this shared drug to the left. Specifically, after pretreatment with Propranolol, this shared drug (at 0.3 mg/ml) increased pulmonary resistance by 7.9 +/- 0.97 cmH2O.... | Amifampridine | Medium | convergence | {"qa_id":"medium_convergence_04368","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Betaxolol and Propranolol both interact with a specific shared drug. Evidence indicates that Propranolol significantly shifted the dose-response curve of thi... | |
medium_convergence_04369 | ARCN1 and CAPZA3 both interact with a shared protein. Evidence for this interaction includes immunoprecipitation and two-hybrid system analysis within a complete COP screen, which demonstrated physical interactions between alpha- and epsilon-COPs and between beta- and delta-COPs. Which disease is associated with this s... | Baralle-Macken syndrome | Medium | convergence | {"qa_id":"medium_convergence_04369","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARCN1 and CAPZA3 both interact with a shared protein. Evidence for this interaction includes immunoprecipitation and two-hybrid system analysis within a comp... | |
medium_convergence_04370 | Both the regulation of T-helper 2 cell differentiation and the regulation of T-helper 17 cell differentiation are subtypes of a shared biological process. Evidence regarding this shared process states: 'Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation.' Which biological proces... | immune effector process | Medium | convergence | {"qa_id":"medium_convergence_04370","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the regulation of T-helper 2 cell differentiation and the regulation of T-helper 17 cell differentiation are subtypes of a shared biological process. Ev... | |
medium_convergence_04371 | SLC3A2 and BSG each interact with more than one shared partner protein. Evidence concerning one shared entity reports that y+LAT-1 protein forms an approximately 135-kDa, disulfide bond-dependent heterodimer with 4F2hc in oocytes, which upon reduction results in two protein bands of approximately 85 kDa (i.e. 4F2hc) an... | Large neutral amino acids transporter small subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_04371","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SLC3A2 and BSG each interact with more than one shared partner protein. Evidence concerning one shared entity reports that y+LAT-1 protein forms an approxima... | |
medium_convergence_04372 | BMPR2 and AXIN1 both interact with a specific protein. Evidence indicates that essential domains of Axin are responsible for the interaction with this protein, as well as for its mediated down-regulation and ubiquitination. Which protein product is encoded by this interacting protein? | E3 ubiquitin-protein ligase SMURF2 | Medium | convergence | {"qa_id":"medium_convergence_04372","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMPR2 and AXIN1 both interact with a specific protein. Evidence indicates that essential domains of Axin are responsible for the interaction with this protei... | |
medium_convergence_04373 | NLGN1 and WNT7A are both involved in a shared biological process. Evidence regarding this process states: 'We found that Wnt7a and Wnt7b activate canonical signaling, whereas Wnt5a activates a noncanonical pathway. The activation of the canonical pathway, either through pathway manipulations or through Wnt stimulation,... | synapse assembly | Medium | convergence | {"qa_id":"medium_convergence_04373","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NLGN1 and WNT7A are both involved in a shared biological process. Evidence regarding this process states: 'We found that Wnt7a and Wnt7b activate canonical s... | |
medium_convergence_04374 | CDK2 and E2F5 share multiple binding partners. One such partner is described in the context: 'Although it is known that the retinoblastoma family protein physically associates with E- and A-type cyclin/cyclin-dependent kinase 2 complexes through a cyclin-binding RXL motif located in the spacer domain.' Which protein is... | Retinoblastoma-like protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04374","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and E2F5 share multiple binding partners. One such partner is described in the context: 'Although it is known that the retinoblastoma family protein phy... | |
medium_convergence_04375 | Both Human alphaherpesvirus 1 and Rhinovirus A are associated with the downregulation of a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately -1.456 and an adjusted p-value of 0.003829. Which protein is encoded by this gene? | Interleukin-6 | Medium | convergence | {"qa_id":"medium_convergence_04375","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Rhinovirus A are associated with the downregulation of a specific gene. Experimental data for this gene in a monocytic leuk... | |
medium_convergence_04376 | Both Measles morbillivirus and Rift Valley fever phlebovirus are known to upregulate a specific shared gene. Experimental data for this gene in pleural mesothelioma cells (from study GSE117668) reports a log2 fold change of approximately 1.06 and an adjusted p-value of 0.02375. Which disease is associated with this gen... | viral hepatitis | Medium | convergence | {"qa_id":"medium_convergence_04376","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Rift Valley fever phlebovirus are known to upregulate a specific shared gene. Experimental data for this gene in pleural mesot... | |
medium_convergence_04377 | FANCC and FANCB both interact with a specific shared protein. Evidence regarding this shared protein states: 'Here, we report a novel component of this complex, termed FAAP100, which is essential for the stability of the core complex and directly interacts with FANCB and this shared protein to form a stable subcomplex.... | UBE2W | Medium | convergence | {"qa_id":"medium_convergence_04377","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCC and FANCB both interact with a specific shared protein. Evidence regarding this shared protein states: 'Here, we report a novel component of this compl... | |
medium_convergence_04378 | Human polyomavirus 1 and Primate bocaparvovirus 1 are both reported to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of 2.851 and an adjusted p-value of 0.009472. Which cell type is this gene enriched in? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_04378","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Primate bocaparvovirus 1 are both reported to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fo... | |
medium_convergence_04379 | Rhinovirus A and Cardiovirus A both downregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of -1.527 and an adjusted p-value of 0.006708. Which protein is encoded by this gene? | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_04379","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Cardiovirus A both downregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fol... | |
medium_convergence_04380 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study of cervical adenocarcinoma cell lines (GSE11238), this gene exhibited a log2 fold change of -1.082 and an adjusted p-value of 0.04885. Which protein is encoded by this gene? | BCL11 transcription factor A | Medium | convergence | {"qa_id":"medium_convergence_04380","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study of cervical adenocarcinoma cell lines (GSE11238), this gene exhibite... | |
medium_convergence_04381 | CTBP1 and EP300 both interact with a shared protein. Evidence regarding this shared protein states: 'In this study, we show by coimmunoprecipitation that a zinc finger E-box-binding homeobox protein and CtBP interact in vivo and that an isolated CtBP-binding fragment of this protein depends on CtBP for transcriptional ... | Zinc finger E-box-binding homeobox 2 | Medium | convergence | {"qa_id":"medium_convergence_04381","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and EP300 both interact with a shared protein. Evidence regarding this shared protein states: 'In this study, we show by coimmunoprecipitation that a z... | |
medium_convergence_04382 | Both the lumbar vertebra endochondral element and the sacral vertebra endochondral element share a common anatomical classification. Evidence regarding one of these shared entities describes it as a lumbar vertebra bone, its cartilage, or its pre-cartilage precursor. Which anatomical entity is connected to this describ... | skeletal element | Medium | convergence | {"qa_id":"medium_convergence_04382","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the lumbar vertebra endochondral element and the sacral vertebra endochondral element share a common anatomical classification. Evidence regarding one o... | |
medium_convergence_04383 | RHOJ and CDC42 both interact with a specific shared protein. Experimental evidence indicates that mutations V42A and L174A in the GTPase cause large, selective changes in binding to specific CRIB effectors. Specifically, neither mutation alters binding to PAK, but both severely disrupt binding to ACK. Crucially, only t... | Actin nucleation-promoting factor WAS | Medium | convergence | {"qa_id":"medium_convergence_04383","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOJ and CDC42 both interact with a specific shared protein. Experimental evidence indicates that mutations V42A and L174A in the GTPase cause large, selecti... | |
medium_convergence_04384 | Both Vaccinia virus and Measles morbillivirus are known to downregulate the expression of a specific shared gene. In a study using a cervical adenocarcinoma cell line (GSE11238), evidence for this gene shows a log2 fold change of approximately -1.501 and an adjusted p-value of 0.03128. Which cellular component is this ... | membrane | Medium | convergence | {"qa_id":"medium_convergence_04384","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Measles morbillivirus are known to downregulate the expression of a specific shared gene. In a study using a cervical adenocarcinoma ... | |
medium_convergence_04385 | ATR and RUVBL1 share a common interacting partner. Evidence indicates that this shared partner interacts with and stabilizes all six members of the PIKK family of proteins (mTOR, ATM, ATR, DNA-PKcs, SMG-1, and TRRAP). Which disease is associated with this shared partner? | neurodevelopmental disorder with microcephaly and movement abnormalities | Medium | convergence | {"qa_id":"medium_convergence_04385","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATR and RUVBL1 share a common interacting partner. Evidence indicates that this shared partner interacts with and stabilizes all six members of the PIKK fami... | |
medium_convergence_04386 | Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data from a study on retinal pigment epithelium cells (GSE100839) indicates that this gene has a log2 fold change of -1.458 and an adjusted p-value of 0.002794. Which disease is associated with this gene through genomic alterations? | Metaphyseal chondrodysplasia, McKusick type | Medium | convergence | {"qa_id":"medium_convergence_04386","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data from a study on retinal pigment epithelium cells (GSE100839) indicates t... | |
medium_convergence_04387 | Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. In cytotoxic T-lymphocytes, experimental data for this gene shows a log2 fold change of -1.334 and an adjusted p-value of 0.02198. Which protein does this gene product interact with? | RNH1 | Medium | convergence | {"qa_id":"medium_convergence_04387","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. In cytotoxic T-lymphocytes, experimental data for this gene shows a log2 fold ch... | |
medium_convergence_04388 | Alemtuzumab and Efalizumab both interact with a specific shared drug. Clinical evidence indicates that adding monoclonal antibodies, such as rituximab and this shared drug, to purine analogues (alone or in combination) appears more effective for chemotherapy-naive and pretreated CLL patients. Which disease is this shar... | hairy cell leukemia | Medium | convergence | {"qa_id":"medium_convergence_04388","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Alemtuzumab and Efalizumab both interact with a specific shared drug. Clinical evidence indicates that adding monoclonal antibodies, such as rituximab and th... | |
medium_convergence_04390 | NOTCH1 and KAT2B each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Nuclear ICN binds to a highly conserved DNA-binding transcription factor called CSL (also known as RBP-Jkappa, Suppressor of Hairless, and Lag-1) and recruits Mastermind-like transcriptional co-... | Recombining binding protein suppressor of hairless | Medium | convergence | {"qa_id":"medium_convergence_04390","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NOTCH1 and KAT2B each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Nuclear ICN binds to a highly c... | |
medium_convergence_04391 | G3BP1 and PARP1 both interact with a shared protein. Evidence regarding this shared protein states: 'Extended analysis of the interaction with G3BP1, a master stress response factor, uncovers an unexpected role and mechanism in regulating stress granule assembly and cellular stress resistance.' Which protein is encoded... | NAD-dependent protein deacylase sirtuin-6 | Medium | convergence | {"qa_id":"medium_convergence_04391","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"G3BP1 and PARP1 both interact with a shared protein. Evidence regarding this shared protein states: 'Extended analysis of the interaction with G3BP1, a maste... | |
medium_convergence_04393 | BIRC3 and BIRC6 both interact with a shared protein. Evidence regarding this shared entity states: 'Similarly to XIAP, in vitro binding experiments indicated that c-IAP-1 and c-IAP-2 bound specifically to the terminal effector cell death proteases, caspases-3 and -7, but not to the proximal protease caspase-8, caspases... | medulloblastoma | Medium | convergence | {"qa_id":"medium_convergence_04393","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC3 and BIRC6 both interact with a shared protein. Evidence regarding this shared entity states: 'Similarly to XIAP, in vitro binding experiments indicated... | |
medium_convergence_04395 | Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE100839) reports a log2 fold change of approximately -1.016 and an adjusted p-value of 0.004531. Which protein does this gene product bind to? | TCF7L2 | Medium | convergence | {"qa_id":"medium_convergence_04395","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE100839... | |
medium_convergence_04396 | RUVBL2 and ATR share common interaction partners. One such shared partner is known to interact with and stabilize all six members of the PIKK family of proteins (mTOR, ATM, ATR, DNA-PKcs, SMG-1, and TRRAP). Which disease is associated with this specific shared partner? | neurodevelopmental disorder with microcephaly and movement abnormalities | Medium | convergence | {"qa_id":"medium_convergence_04396","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RUVBL2 and ATR share common interaction partners. One such shared partner is known to interact with and stabilize all six members of the PIKK family of prote... | |
medium_convergence_04397 | Human betaherpesvirus 5 and West Nile virus both upregulate a specific gene. Experimental data for this gene in monocytes shows a log2 fold change of approximately 1.455 and an adjusted p-value of 0.008402. Which protein is encoded by this gene? | Interferon-induced protein with tetratricopeptide repeats 5 | Medium | convergence | {"qa_id":"medium_convergence_04397","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and West Nile virus both upregulate a specific gene. Experimental data for this gene in monocytes shows a log2 fold change of approxi... | |
medium_convergence_04398 | CNOT1 and CNOT6L both interact with a shared protein. Evidence regarding this shared protein states: 'We found that human GW182 proteins recruit the PAN2-PAN3 and CCR4-CAF1-NOT deadenylase complexes through direct interactions with PAN3 and NOT1, respectively.' Which protein is encoded by the gene corresponding to this... | Trinucleotide repeat-containing gene 6C protein | Medium | convergence | {"qa_id":"medium_convergence_04398","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CNOT1 and CNOT6L both interact with a shared protein. Evidence regarding this shared protein states: 'We found that human GW182 proteins recruit the PAN2-PAN... | |
medium_convergence_04399 | CDK4 and CDK6 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that Thr172-phosphorylated CDK4 was enriched in complexes containing p21 or p27, even at inhibitory levels of p27 that precluded CDK4 activity. Which protein is encoded by the gene correspon... | Cyclin-dependent kinase inhibitor 1B | Medium | convergence | {"qa_id":"medium_convergence_04399","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK4 and CDK6 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that Thr172-phosphorylated ... | |
medium_convergence_04400 | PIK3R4 and PIK3C3 both interact with a specific protein. Evidence regarding this protein states: 'Although both human Atg14 and this protein interact with Beclin 1 and Vps34, Atg14 and this protein are not present in the same complex.' Which protein is encoded by the gene corresponding to this entity? | UV radiation resistance-associated gene protein | Medium | convergence | {"qa_id":"medium_convergence_04400","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PIK3R4 and PIK3C3 both interact with a specific protein. Evidence regarding this protein states: 'Although both human Atg14 and this protein interact with Be... | |
medium_convergence_04401 | MAPRE1 and MAPT share interaction partners. One such shared partner is described in evidence stating: 'We show that axotrophin, a RING-variant domain containing protein with similarity to E3 ubiquitin ligases interacts with tau.' Which protein is encoded by this shared entity? | E3 ubiquitin-protein ligase MARCHF7 | Medium | convergence | {"qa_id":"medium_convergence_04401","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPRE1 and MAPT share interaction partners. One such shared partner is described in evidence stating: 'We show that axotrophin, a RING-variant domain contain... | |
medium_convergence_04402 | Dengue virus and Enterovirus A both downregulate a specific gene in hepatoma cells. Experimental data from study GSE110512 indicates that this gene exhibits a log2 fold change of -1.949 and an adjusted p-value of 0.01786. Which protein is encoded by this gene? | Translocating chain-associated membrane protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04402","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both downregulate a specific gene in hepatoma cells. Experimental data from study GSE110512 indicates that this gene exhibits ... | |
medium_convergence_04403 | CSNK2B and MDM2 share multiple interacting partners. One such shared partner is a stress sensor that interacts with the E3 ligase MDM2 to suppress SLUG degradation in alveolar epithelial type 2 (AEC2) cells by impeding MDM2-catalyzed SLUG ubiquitination. Which protein is encoded by this shared partner? | Tribbles homolog 3 | Medium | convergence | {"qa_id":"medium_convergence_04403","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2B and MDM2 share multiple interacting partners. One such shared partner is a stress sensor that interacts with the E3 ligase MDM2 to suppress SLUG degra... | |
medium_convergence_04404 | Retina layer formation and retinal bipolar neuron differentiation are both components of a shared biological process. Evidence for this shared process describes the organization of the vertebrate retina into three nuclear laminae: the outer nuclear layer (ONL) containing photoreceptor nuclei, the inner nuclear layer (I... | anatomical structure development | Medium | convergence | {"qa_id":"medium_convergence_04404","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Retina layer formation and retinal bipolar neuron differentiation are both components of a shared biological process. Evidence for this shared process descri... | |
medium_convergence_04407 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhibited a log2 fold change of approximately -1.84 and an adjusted p-value of 0.006. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_04407","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhi... | |
medium_convergence_04408 | F8 and GOLGA2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'The GTP form of this protein regulates ER to Golgi transport by interaction with the vesicle tethering factor p115 and the cis-Golgi matrix protein GM130, also part of a complex with GRASP65 important for the ... | prostate cancer | Medium | convergence | {"qa_id":"medium_convergence_04408","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"F8 and GOLGA2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'The GTP form of this protein regulates ER to G... | |
medium_convergence_04410 | CHD3 and BRD4 share common interaction partners. One such shared partner is involved in a mechanism where KAP-1(Ser824) phosphorylation generates a motif that directly perturbs interactions between the partner's SUMO-interacting motif and the partner itself, leading to the dispersal of the partner from heterochromatin ... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_04410","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and BRD4 share common interaction partners. One such shared partner is involved in a mechanism where KAP-1(Ser824) phosphorylation generates a motif tha... | |
medium_convergence_04411 | COMMD1 and CUL3 both interact with a specific protein. Evidence indicates that this protein binds DAPK and Cullin 3 via its Kelch-repeat domain and BTB domain, respectively. Which cell type is this protein enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_04411","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL3 both interact with a specific protein. Evidence indicates that this protein binds DAPK and Cullin 3 via its Kelch-repeat domain and BTB domai... | |
medium_convergence_04412 | CEBPB and MYC share interaction partners. One such shared partner is described by evidence stating: 'Immunoprecipitation-immunoblotting, chromatin immunoprecipitation, and GST pull-down assays revealed that a corepressor recruited to steroid-GR complex for histone deacetylation, bound to TAD domain of C/EBPbeta and Neh... | Nuclear receptor corepressor 2 | Medium | convergence | {"qa_id":"medium_convergence_04412","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPB and MYC share interaction partners. One such shared partner is described by evidence stating: 'Immunoprecipitation-immunoblotting, chromatin immunoprec... | |
medium_convergence_04413 | Human betaherpesvirus 5 and Human gammaherpesvirus 4 both downregulate a specific gene. Evidence for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately -1.598 and an adjusted p-value of 0.03692. Which disease is associated with this gene as a biomarker? | alcohol abuse | Medium | convergence | {"qa_id":"medium_convergence_04413","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human gammaherpesvirus 4 both downregulate a specific gene. Evidence for this gene in foreskin fibroblast cell lines reports a lo... | |
medium_convergence_04414 | MAX and MYC both interact with a shared protein. Evidence indicates that Reptin interacts with the c-MYC oncoprotein, and this interaction's stimulatory effect on the hTERT promoter is significantly dependent on functional E-boxes. Which disease is associated with this shared protein? | prostate cancer | Medium | convergence | {"qa_id":"medium_convergence_04414","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAX and MYC both interact with a shared protein. Evidence indicates that Reptin interacts with the c-MYC oncoprotein, and this interaction's stimulatory effe... | |
medium_convergence_04415 | CRK and ALK share common interaction partners. One such shared partner was identified via LC/MS-MS analysis, which detected multiple proteins, including this entity and SHP2, and validated them as interactors in neuroblastoma (NB) cells. Which protein is encoded by this shared interaction partner? | Inactive tyrosine-protein kinase PEAK1 | Medium | convergence | {"qa_id":"medium_convergence_04415","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and ALK share common interaction partners. One such shared partner was identified via LC/MS-MS analysis, which detected multiple proteins, including this... | |
medium_convergence_04416 | The embryonic cloaca and the urorectal septum are both components of a specific anatomical structure. Evidence regarding this shared structure describes it as an endoderm-lined chamber that develops as a pouch-like dilation of the caudal end of the hindgut, receiving the allantois ventrally and two mesonephric ducts la... | multi-tissue structure | Medium | convergence | {"qa_id":"medium_convergence_04416","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The embryonic cloaca and the urorectal septum are both components of a specific anatomical structure. Evidence regarding this shared structure describes it a... |
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