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medium_convergence_04186 | Acarbose and Metformin both interact with a specific drug. Evidence indicates that several agents, including sucralfate, cytotoxic agents, and enzyme inducers, can reduce the plasma concentrations of this drug. Which disease is this drug indicated for? | heart failure | Medium | convergence | {"qa_id":"medium_convergence_04186","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Acarbose and Metformin both interact with a specific drug. Evidence indicates that several agents, including sucralfate, cytotoxic agents, and enzyme inducer... | |
medium_convergence_04187 | SMAD2 and SMAD3 both interact with a specific protein that contains leucine-rich repeats and a PDZ (PSD-95/DLG/ZO-1) domain. This protein interacts specifically with SMAD3 and, to a lesser extent, with SMAD2 through a novel Smad-interacting domain (SID) adjacent to its PDZ domain. Which disease is associated with this ... | congestive heart failure | Medium | convergence | {"qa_id":"medium_convergence_04187","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD2 and SMAD3 both interact with a specific protein that contains leucine-rich repeats and a PDZ (PSD-95/DLG/ZO-1) domain. This protein interacts specifica... | |
medium_convergence_04188 | ERBB2 and FGFR1 both interact with a shared protein. Evidence indicates that the ERM proteins ezrin and a related ERM family member are associated with this shared entity's receptors at the plasma membrane. Which cell type is this shared entity enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_04188","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and FGFR1 both interact with a shared protein. Evidence indicates that the ERM proteins ezrin and a related ERM family member are associated with this ... | |
medium_convergence_04189 | Both Measles morbillivirus and Human orthopneumovirus are associated with the upregulation of a specific gene. In a study (GSE131840), this gene exhibited a log2 fold change of approximately 1.033 and an adjusted p-value of 0.04012. Which protein is encoded by this gene? | Ataxin-2-like protein | Medium | convergence | {"qa_id":"medium_convergence_04189","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Human orthopneumovirus are associated with the upregulation of a specific gene. In a study (GSE131840), this gene exhibited a ... | |
medium_convergence_04190 | NR3C1 and MYC both interact with a shared gene product. Experimental evidence indicates that mammalian two-hybrid assays and glutathione S-transferase pull-down assays revealed a direct association between this entity and the glucocorticoid receptor DNA-binding domain (GR DBD). Which disease is associated with this ent... | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04190","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NR3C1 and MYC both interact with a shared gene product. Experimental evidence indicates that mammalian two-hybrid assays and glutathione S-transferase pull-d... | |
medium_convergence_04191 | CCDC22 and CUL3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that Aurora B directly binds to the substrate-recognition domain of this entity in vitro and coimmunoprecipitates with the CUL3 complex during mitosis. Which protein is encoded by the gene c... | Kelch-like protein 9 | Medium | convergence | {"qa_id":"medium_convergence_04191","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCDC22 and CUL3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that Aurora B directly bind... | |
medium_convergence_04192 | PABPC1 and YWHAH share multiple interacting partners. One such shared partner is supported by evidence stating: 'Among these, the interactions between hTTP and CIN85, cytoplasmic poly (A) binding protein (PABP), nucleolin and heat shock protein 70 were confirmed by co-immunoprecipitation experiments.' Which protein is ... | mRNA decay activator protein ZFP36 | Medium | convergence | {"qa_id":"medium_convergence_04192","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PABPC1 and YWHAH share multiple interacting partners. One such shared partner is supported by evidence stating: 'Among these, the interactions between hTTP a... | |
medium_convergence_04193 | COPS5 and MYC both interact with a shared protein. Evidence regarding this shared protein states: 'We confirmed a direct interaction of Jab1 with LMP-1 using recombinantly expressed wild-type and mutant proteins in slot-blot-binding assays.' Which protein is encoded by this shared entity? | PDZ and LIM domain protein 7 | Medium | convergence | {"qa_id":"medium_convergence_04193","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and MYC both interact with a shared protein. Evidence regarding this shared protein states: 'We confirmed a direct interaction of Jab1 with LMP-1 using... | |
medium_convergence_04194 | GNB5 and CCT8 both interact with a shared protein. Evidence indicates that this protein is a member of the R7 RGS family, which forms trimeric complexes with the atypical G protein β subunit Gβ5 and membrane anchors R7BP or R9AP. Which protein is encoded by the gene corresponding to this shared entity? | Regulator of G-protein signaling 9 | Medium | convergence | {"qa_id":"medium_convergence_04194","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNB5 and CCT8 both interact with a shared protein. Evidence indicates that this protein is a member of the R7 RGS family, which forms trimeric complexes with... | |
medium_convergence_04195 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.043 and an adjusted p-value of 8.674e-06. Which disease is associate... | severe combined immunodeficiency due to CORO1A deficiency | Medium | convergence | {"qa_id":"medium_convergence_04195","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific gene. Experimental data for this... | |
medium_convergence_04196 | ANAPC2 and ANAPC7 both interact with a specific protein. Evidence regarding this shared interaction partner notes that a specific APC subunit also binds APC16 and APC7 and contains a >200-residue loop that is heavily phosphorylated during mitosis, although the basis for its interactions and whether loop phosphorylation... | Cell division cycle protein 27 homolog | Medium | convergence | {"qa_id":"medium_convergence_04196","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC2 and ANAPC7 both interact with a specific protein. Evidence regarding this shared interaction partner notes that a specific APC subunit also binds APC1... | |
medium_convergence_04197 | ERG and HDAC1 share common interaction partners. One such shared partner is supported by evidence stating that coimmunoprecipitation experiments indicate its association with HDAC2 and Topo II in vivo under normal physiological conditions. Which disease is associated with this shared partner? | B-cell immunodeficiency, distal limb anomalies, and urogenital malformations | Medium | convergence | {"qa_id":"medium_convergence_04197","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERG and HDAC1 share common interaction partners. One such shared partner is supported by evidence stating that coimmunoprecipitation experiments indicate its... | |
medium_convergence_04198 | Vaccinia virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -2.28 and an adjusted p-value of approximately 0.023. Which cellular component is this gene located in? | membrane | Medium | convergence | {"qa_id":"medium_convergence_04198","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) re... | |
medium_convergence_04199 | CRK and CRKL each interact with more than one shared protein. Evidence concerning one such shared entity reports that it dissociated from the guanine exchange factor C3G and bound to the tyrosine kinase encoded by the ABL1 gene during inhibition. Which protein is encoded by the gene corresponding to that entity? | Tyrosine-protein kinase ABL1 | Medium | convergence | {"qa_id":"medium_convergence_04199","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and CRKL each interact with more than one shared protein. Evidence concerning one such shared entity reports that it dissociated from the guanine exchang... | |
medium_convergence_04200 | BRCA1 and FAM175A share common binding partners. One such shared partner contains a COOH-terminal HECT-containing domain that interacts with an NH(2)-terminal degron domain in BRCA1. Which disease is associated with this specific shared partner via a biomarker relationship? | autism spectrum disorder | Medium | convergence | {"qa_id":"medium_convergence_04200","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRCA1 and FAM175A share common binding partners. One such shared partner contains a COOH-terminal HECT-containing domain that interacts with an NH(2)-termina... | |
medium_convergence_04201 | CUL1 and BTRC both interact with a shared protein. Evidence regarding this shared entity states: 'This study reveals novel key molecular events in Wnt signaling: induction of Gsk3β ubiquitination and Gsk3β-β-TrCP binding.' Which disease is associated with this shared protein? | telangiectasis | Medium | convergence | {"qa_id":"medium_convergence_04201","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CUL1 and BTRC both interact with a shared protein. Evidence regarding this shared entity states: 'This study reveals novel key molecular events in Wnt signal... | |
medium_convergence_04202 | NPLOC4 and VCP share multiple interacting partners. One such partner is described as a cofactor of the hexameric ATPase complex known as p97 (or VCP) in mammals and Cdc48 in yeast. Which biological process is this specific shared partner involved in? | positive regulation of protein modification process | Medium | convergence | {"qa_id":"medium_convergence_04202","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NPLOC4 and VCP share multiple interacting partners. One such partner is described as a cofactor of the hexameric ATPase complex known as p97 (or VCP) in mamm... | |
medium_convergence_04204 | DIAPH1 and DIAPH2 both bind to a specific shared protein. Evidence indicates that a novel splice variant of human Diaphanous, hDia2C, specifically binds to this shared entity and is recruited onto early endosomes. Which gene interacts with this shared entity? | SOWAHC | Medium | convergence | {"qa_id":"medium_convergence_04204","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DIAPH1 and DIAPH2 both bind to a specific shared protein. Evidence indicates that a novel splice variant of human Diaphanous, hDia2C, specifically binds to t... | |
medium_convergence_04205 | BET1 and COG4 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'Our results suggest that COG4 serves as a core component of the complex by interacting directly with COG1, COG2, COG5, and this shared protein.' Which protein is connected to this shared protein thro... | Conserved oligomeric Golgi complex subunit 7 | Medium | convergence | {"qa_id":"medium_convergence_04205","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BET1 and COG4 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'Our results suggest that COG4 serves... | |
medium_convergence_04206 | CRKL and ITK both interact with a common protein. Evidence regarding one such shared partner states: 'Third, the Itk Src homology (SH3) 3 and SH2 domains interact cooperatively with Syk-phosphorylated [the protein encoded by LCP2].' Which protein is encoded by the gene corresponding to this shared partner? | Lymphocyte cytosolic protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04206","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRKL and ITK both interact with a common protein. Evidence regarding one such shared partner states: 'Third, the Itk Src homology (SH3) 3 and SH2 domains int... | |
medium_convergence_04207 | ACTR1A and ACTR10 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Affinity chromatography experiments demonstrate that a specific protein binds directly to the Arp1 subunit of dynactin.' Which disease is associated with that specific shared partner thro... | cystic fibrosis | Medium | convergence | {"qa_id":"medium_convergence_04207","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR1A and ACTR10 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Affinity chromatography ... | |
medium_convergence_04208 | Both Human polyomavirus 1 and Human immunodeficiency virus 1 are reported to upregulate a specific gene. Evidence for this shared target indicates a log2 fold change of approximately 1.919 and an adjusted p-value of 0.04374. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_04208","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human polyomavirus 1 and Human immunodeficiency virus 1 are reported to upregulate a specific gene. Evidence for this shared target indicates a log2 fol... | |
medium_convergence_04210 | DLG4 and RHOB both interact with a shared protein. Evidence indicates that this protein is a microtubule-associated protein, which exhibits high-affinity in vivo interaction with PSD-93 via its guanylate kinase domain. Which cell type is enriched for this protein? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_04210","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG4 and RHOB both interact with a shared protein. Evidence indicates that this protein is a microtubule-associated protein, which exhibits high-affinity in ... | |
medium_convergence_04211 | BIRC3 and TRAF2 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We now report a novel mechanism of TRAF2-mediated signal transduction revealed by an association of TRAF2 with sphingosine kinase, a lipid kinase that is responsible for the production of sphingosine 1-phosphate... | Sphingosine kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_04211","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC3 and TRAF2 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We now report a novel mechanism of TRAF2-mediate... | |
medium_convergence_04213 | Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene exhibits a log2 fold change of -3.826 and an adjusted p-value of 0.02704. Which protein does this gene product bind to? | RBSN | Medium | convergence | {"qa_id":"medium_convergence_04213","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indic... | |
medium_convergence_04214 | KLHL3 and WNK1 both interact with a shared protein. Evidence indicates that this shared protein interacts with Cullin3, undergoes ubiquitination induced by KLHL3, and experiences reduced protein levels as a result. Which cellular component is this shared protein located in? | bicellular tight junction | Medium | convergence | {"qa_id":"medium_convergence_04214","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KLHL3 and WNK1 both interact with a shared protein. Evidence indicates that this shared protein interacts with Cullin3, undergoes ubiquitination induced by K... | |
medium_convergence_04216 | COPS4 and COPS2 each interact with more than one shared protein. Evidence concerning one shared entity reports that TA binds CSN4 and the synaptic regulator snapin in neuroblastoma cells and in brain synaptosomes. Which protein is connected to that entity through the 'encodes' relationship? | Torsin-1A | Medium | convergence | {"qa_id":"medium_convergence_04216","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS4 and COPS2 each interact with more than one shared protein. Evidence concerning one shared entity reports that TA binds CSN4 and the synaptic regulator ... | |
medium_convergence_04217 | CCT2 and GABARAP both interact with a specific shared protein. Evidence indicates that this protein undergoes a modification mediated by IKKα kinase, which induces structural changes promoting its interaction with LC3/GABARAP (mATG8) proteins and enhancing its mitophagic activity. Which protein is encoded by the gene c... | Activating molecule in BECN1-regulated autophagy protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04217","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCT2 and GABARAP both interact with a specific shared protein. Evidence indicates that this protein undergoes a modification mediated by IKKα kinase, which i... | |
medium_convergence_04219 | The facial nucleus and the nucleus of the medulla oblongata share a common anatomical classification. Evidence regarding one such shared entity describes it as 'The group of motor neurons residing in the pons that innervate the muscles of facial expression.' To which larger anatomical structure is this shared entity a ... | brainstem | Medium | convergence | {"qa_id":"medium_convergence_04219","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The facial nucleus and the nucleus of the medulla oblongata share a common anatomical classification. Evidence regarding one such shared entity describes it ... | |
medium_convergence_04220 | SKP2 and CUL1 both interact with a shared protein entity. Evidence indicates that this shared entity forms complexes with cyclin A, a protein particularly abundant in cancer cells due to frequent overexpression of the shared entity, although the mechanism and significance of this interaction remain unknown. Which prote... | Cyclin-A1 | Medium | convergence | {"qa_id":"medium_convergence_04220","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SKP2 and CUL1 both interact with a shared protein entity. Evidence indicates that this shared entity forms complexes with cyclin A, a protein particularly ab... | |
medium_convergence_04221 | Both Human alphaherpesvirus 3 and Human immunodeficiency virus 1 are known to downregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.179 and an adjusted p-value of 4.463e-05. Which disease is associated with this gene... | colon carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04221","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Human immunodeficiency virus 1 are known to downregulate a specific shared gene. Experimental data for this gene in a melan... | |
medium_convergence_04223 | ARFRP1 and ARL1 both interact with a shared protein partner. Evidence indicates that the GTP-bound form of this shared partner interacts with the GRIP domains of Golgin-97 and Golgin-245, a process dependent on conserved residues within those GRIP domains that are critical for Golgi targeting. Which gene encodes this s... | GRIP and coiled-coil domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04223","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARFRP1 and ARL1 both interact with a shared protein partner. Evidence indicates that the GTP-bound form of this shared partner interacts with the GRIP domain... | |
medium_convergence_04224 | Both Human immunodeficiency virus 1 and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data for this gene, derived from macrophages in study GSE108897, indicates a log2 fold change of -2.656 and an adjusted p-value of 0.02236. Which disease is associated with this gene as a biomarker? | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_04224","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data for this gene, derived from macr... | |
medium_convergence_04226 | CTCF and WWP2 both interact with a specific shared protein. Experimental evidence indicates that the association and simultaneous presence of this shared protein and another protein at the ICR, confirmed by single and serial chromatin immunoprecipitation assays, are independent of the shared protein's poly(ADP-ribosyl)... | Poly [ADP-ribose] polymerase 1 | Medium | convergence | {"qa_id":"medium_convergence_04226","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTCF and WWP2 both interact with a specific shared protein. Experimental evidence indicates that the association and simultaneous presence of this shared pro... | |
medium_convergence_04227 | KRAS and RAB14 both interact with a shared protein. Evidence regarding this shared protein states: 'In the present study we identify the class I FIPs as dual Rab-binding proteins by demonstrating that they also interact with RAB14 in a GTP-dependent manner.' Which protein is encoded by the gene corresponding to this sh... | Rab11 family-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04227","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRAS and RAB14 both interact with a shared protein. Evidence regarding this shared protein states: 'In the present study we identify the class I FIPs as dual... | |
medium_convergence_04228 | FOXE3 and PAX6 are both involved in multiple shared biological processes. One shared process is associated with an entity where evidence states: 'In addition to the lens, most tissues of the anterior segment-iris, cornea, ciliary body and trabecular meshwork-are malformed or show differentiation defects.' Which biologi... | anatomical structure development | Medium | convergence | {"qa_id":"medium_convergence_04228","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FOXE3 and PAX6 are both involved in multiple shared biological processes. One shared process is associated with an entity where evidence states: 'In addition... | |
medium_convergence_04229 | Vaccinia virus and Dengue virus both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of 3.427 and an adjusted p-value of 7.673e-09. Which disease is associated with this gene through genomic alterations? | lung neoplasm | Medium | convergence | {"qa_id":"medium_convergence_04229","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Dengue virus both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) show... | |
medium_convergence_04230 | COPS6 and CUL4B both interact with a shared protein partner. Evidence indicates that this shared partner is required for CUL4B to bind to UV-damaged chromatin as part of a specific E3 ligase complex. Which protein is encoded by this shared partner? | DNA damage-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04230","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS6 and CUL4B both interact with a shared protein partner. Evidence indicates that this shared partner is required for CUL4B to bind to UV-damaged chromati... | |
medium_convergence_04231 | AMFR and HSPA5 both interact with a shared protein. Evidence indicates that the ERAD E3 ligase gp78 ubiquitinates this shared protein, which is a key component of the Bag6 chaperone complex. Which disease is associated with this protein? | premature menopause | Medium | convergence | {"qa_id":"medium_convergence_04231","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AMFR and HSPA5 both interact with a shared protein. Evidence indicates that the ERAD E3 ligase gp78 ubiquitinates this shared protein, which is a key compone... | |
medium_convergence_04234 | LY96 and MAP3K3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Interestingly, we also find that the protein encoded by the shared partner gene and MEKK3 form a functional complex, in which the protein encoded by the shared partner gene regulates autoph... | Mitogen-activated protein kinase kinase kinase 7 | Medium | convergence | {"qa_id":"medium_convergence_04234","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LY96 and MAP3K3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Interestingly, we also fin... | |
medium_convergence_04235 | Dengue virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of -1.917 and an adjusted p-value of 0.01179. What molecular function is enabled by this gene? | RNA binding | Medium | convergence | {"qa_id":"medium_convergence_04235","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fo... | |
medium_convergence_04236 | Both Measles morbillivirus and Human orthopneumovirus are associated with the upregulation of a specific gene entity. Experimental data for this entity indicates a log2 fold change of approximately 2.494 and an adjusted p-value of 0.0005254. Which protein is encoded by this gene entity? | Histone H3.1 | Medium | convergence | {"qa_id":"medium_convergence_04236","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Human orthopneumovirus are associated with the upregulation of a specific gene entity. Experimental data for this entity indic... | |
medium_convergence_04237 | YAP1 and PRDX4 share common protein interaction partners. One such shared partner is described in the following evidence: 'Here, we describe a new human thioredoxin peroxidase, antioxidant enzyme AOE372, identified by virtue of its protein-protein interaction with the product of a proliferation association gene, pag, w... | Peroxiredoxin-1 | Medium | convergence | {"qa_id":"medium_convergence_04237","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and PRDX4 share common protein interaction partners. One such shared partner is described in the following evidence: 'Here, we describe a new human thio... | |
medium_convergence_04239 | IKZF1 and EZH2 share common interaction partners. One such partner is described in evidence stating that Ikaros and its repression domains interact in vivo and in vitro with the mSin3 family of co-repressors, which bind to histone deacetylases. Which protein is encoded by this specific shared interaction partner? | Paired amphipathic helix protein Sin3a | Medium | convergence | {"qa_id":"medium_convergence_04239","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IKZF1 and EZH2 share common interaction partners. One such partner is described in evidence stating that Ikaros and its repression domains interact in vivo a... | |
medium_convergence_04240 | CHUK and IRAK1 each interact with more than one shared protein. Evidence concerning one of these shared proteins reports that IKKalpha and IKKbeta were coimmunoprecipitated with a MAP3K7 family member in the absence of TAB1. Which protein is encoded by the gene corresponding to that shared entity? | Mitogen-activated protein kinase kinase kinase 7 | Medium | convergence | {"qa_id":"medium_convergence_04240","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and IRAK1 each interact with more than one shared protein. Evidence concerning one of these shared proteins reports that IKKalpha and IKKbeta were coimm... | |
medium_convergence_04241 | CFTR and SLC6A1 share a common interacting partner. Experimental evidence indicates that this shared partner coprecipitated with Csp from Calu-3 cell lysates. Which protein is encoded by this shared interacting partner? | DnaJ homolog subfamily C member 5 | Medium | convergence | {"qa_id":"medium_convergence_04241","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CFTR and SLC6A1 share a common interacting partner. Experimental evidence indicates that this shared partner coprecipitated with Csp from Calu-3 cell lysates... | |
medium_convergence_04242 | HDAC2 and AR both interact with a shared protein. Evidence for the interaction between this shared protein and a nuclear receptor was assessed using glutathione-S-transferase (GST) pull-down assays and mammalian two-hybrid system assays. Which biological process is this shared protein involved in? | negative regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_04242","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC2 and AR both interact with a shared protein. Evidence for the interaction between this shared protein and a nuclear receptor was assessed using glutathi... | |
medium_convergence_04244 | RAD50 and KAT5 both interact with a shared protein. Evidence regarding this shared protein states: 'This effect is dependent on a direct interaction between MRN and the tandem breast cancer carboxy-terminal (BRCT) repeats in the shared protein, and is accompanied by hyper-phosphorylation of both Nbs1 and the shared pro... | TP53-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04244","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD50 and KAT5 both interact with a shared protein. Evidence regarding this shared protein states: 'This effect is dependent on a direct interaction between ... | |
medium_convergence_04245 | BTK and CD247 share multiple interacting partners. One such partner is described by evidence stating: 'In CD45-negative T cells, p70zap was constitutively phosphorylated on tyrosine and co-immunoprecipitated with the TcR-zeta chain.' Which protein is encoded by the gene corresponding to this shared partner? | Tyrosine-protein kinase ZAP-70 | Medium | convergence | {"qa_id":"medium_convergence_04245","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BTK and CD247 share multiple interacting partners. One such partner is described by evidence stating: 'In CD45-negative T cells, p70zap was constitutively ph... | |
medium_convergence_04246 | RIG-I and IRF3 share multiple binding partners. One such partner is identified in the literature as REUL, a RING-finger protein that specifically interacts with RIG-I. Which gene does this specific partner (REUL) interact with? | CTNNAL1 | Medium | convergence | {"qa_id":"medium_convergence_04246","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RIG-I and IRF3 share multiple binding partners. One such partner is identified in the literature as REUL, a RING-finger protein that specifically interacts w... | |
medium_convergence_04247 | ARPC4 and CLTC both interact with a specific protein. Evidence regarding this protein states: 'The interaction with clathrin is direct and not mediated by epsin-bound AP-2.' Which protein is encoded by the gene corresponding to this entity? | Epsin-1 | Medium | convergence | {"qa_id":"medium_convergence_04247","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC4 and CLTC both interact with a specific protein. Evidence regarding this protein states: 'The interaction with clathrin is direct and not mediated by ep... | |
medium_convergence_04248 | KCNE5 and KCNE2 are both involved in more than one shared biological process. Evidence indicates that one of these shared processes is linked to an entity shown to modify the transient outward current (I(to)), which plays a key role in determining the repolarization process in the myocardium. Which biological process i... | regulation of cardiac muscle cell membrane repolarization | Medium | convergence | {"qa_id":"medium_convergence_04248","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNE5 and KCNE2 are both involved in more than one shared biological process. Evidence indicates that one of these shared processes is linked to an entity sh... | |
medium_convergence_04249 | DAXX and EZH2 both interact with a specific shared protein. Evidence regarding this shared protein indicates that its recruitment to ND10 bodies from condensed chromatin requires SUMO-1 modification of the protein itself and reflects an interaction between the COOH-terminal domain of DAXX and this protein. Which protei... | Protein PML | Medium | convergence | {"qa_id":"medium_convergence_04249","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAXX and EZH2 both interact with a specific shared protein. Evidence regarding this shared protein indicates that its recruitment to ND10 bodies from condens... | |
medium_convergence_04250 | G3BP1 and EP300 share multiple interacting partners. One such partner is implicated in a specific molecular event: following mitogen stimulation, S6Ks interact with the p300 and p300/CBP-associated factor (PCAF) acetyltransferases. Which disease is associated with this specific interacting partner through genomic alter... | Shprintzen-Goldberg syndrome | Medium | convergence | {"qa_id":"medium_convergence_04250","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"G3BP1 and EP300 share multiple interacting partners. One such partner is implicated in a specific molecular event: following mitogen stimulation, S6Ks intera... | |
medium_convergence_04251 | RARG and NCOA1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'As anticipated from its location, the L454S mutant interacts weakly with CoAs, such as SRC1 and glucocorticoid receptor interacting protein 1 (GRIP1) in gel mobility shift assays and in mammalian two-... | congenital nongoitrous hypothyroidism 6 | Medium | convergence | {"qa_id":"medium_convergence_04251","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RARG and NCOA1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'As anticipated from its location, the... | |
medium_convergence_04252 | KHDRBS1 and HSP90AA1 share multiple interacting partners. One such partner is described in evidence stating: 'Further studies indicated that a receptor-interacting serine/threonine-protein kinase formed a complex with Triad3A and heat shock protein 90 (Hsp90), which is a chaperone protein capable of maintaining the sta... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_04252","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KHDRBS1 and HSP90AA1 share multiple interacting partners. One such partner is described in evidence stating: 'Further studies indicated that a receptor-inter... | |
medium_convergence_04253 | G3BP1 and WWP2 both interact with a shared protein. Evidence indicates that this shared protein is down-regulated in high glucose and palmitic acid (HG/PA)-induced endothelial cells due to c-Jun N-terminal kinase (JNK) activation. Furthermore, WWP2 suppresses HG/PA-induced endothelial injury by catalyzing K63-linked po... | ATP-dependent RNA helicase DDX3X | Medium | convergence | {"qa_id":"medium_convergence_04253","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"G3BP1 and WWP2 both interact with a shared protein. Evidence indicates that this shared protein is down-regulated in high glucose and palmitic acid (HG/PA)-i... | |
medium_convergence_04254 | TRIM28 and DDX17 both interact with a common gene product. Experimental evidence indicates that the interaction between KAP-1 (TRIM28) and this shared entity was verified by co-immunoprecipitation (Co-IP). Which disease is associated with this entity? | melanoma | Medium | convergence | {"qa_id":"medium_convergence_04254","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and DDX17 both interact with a common gene product. Experimental evidence indicates that the interaction between KAP-1 (TRIM28) and this shared entity... | |
medium_convergence_04255 | BUB3 and AURKB each interact with more than one shared gene partner. Evidence concerning one shared entity reports: 'Here we report the identification of Dasra A and Dasra B, two new components of the vertebrate chromosomal passenger complex containing Incenp, Survivin, and the kinase Aurora B, and demonstrate that thi... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_04255","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BUB3 and AURKB each interact with more than one shared gene partner. Evidence concerning one shared entity reports: 'Here we report the identification of Das... | |
medium_convergence_04256 | FANCG and BLM both physically associate with a specific shared protein partner. Experimental evidence indicates that TPR-mutated forms of FANCG fail to interact with BRCA2, this shared partner, FANCA, or FANCF. Which gene is known to interact with this shared partner? | TRIM25 | Medium | convergence | {"qa_id":"medium_convergence_04256","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCG and BLM both physically associate with a specific shared protein partner. Experimental evidence indicates that TPR-mutated forms of FANCG fail to inter... | |
medium_convergence_04257 | Both Human alphaherpesvirus 3 and Enterovirus A are known to downregulate a specific gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.009 and an adjusted p-value of 3.235e-08. Which disease is associated with this gene? | aural atresia, congenital | Medium | convergence | {"qa_id":"medium_convergence_04257","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Enterovirus A are known to downregulate a specific gene. Experimental data from a melanoma cell line study (GSE136586) indi... | |
medium_convergence_04258 | AKAP10 and AKAP5 both interact with a shared protein partner. Evidence regarding this partner states: 'Based on coprecipitation assays, the R binding domain interacts with the N-terminal dimerization domain of RIalpha and RIIalpha.' Which disease is associated with this shared protein partner as a biomarker? | neonatal severe primary hyperparathyroidism | Medium | convergence | {"qa_id":"medium_convergence_04258","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP10 and AKAP5 both interact with a shared protein partner. Evidence regarding this partner states: 'Based on coprecipitation assays, the R binding domain ... | |
medium_convergence_04259 | EZH2 and FANCD2 share common interaction partners. One such shared partner is described in evidence stating: 'We found that FANCD2 can interact directly with minichromosome maintenance (MCM) proteins.' Which protein is encoded by this shared interaction partner? | DNA replication licensing factor MCM7 | Medium | convergence | {"qa_id":"medium_convergence_04259","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EZH2 and FANCD2 share common interaction partners. One such shared partner is described in evidence stating: 'We found that FANCD2 can interact directly with... | |
medium_convergence_04260 | IL12RB1 and IL23A are both involved in more than one shared biological process. One such shared process is supported by evidence stating: 'These data support the role of IL-23 in inflammation through stimulating IL-17 production by T lymphocytes.' Which biological process is positively regulated by this specific shared... | T-helper 17 type immune response | Medium | convergence | {"qa_id":"medium_convergence_04260","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL12RB1 and IL23A are both involved in more than one shared biological process. One such shared process is supported by evidence stating: 'These data support... | |
medium_convergence_04261 | Both Measles morbillivirus and Dengue virus are known to upregulate a specific shared gene. Experimental data for this gene in pleural mesothelioma cells (from study GSE117668) reports a log2 fold change of approximately 1.093 and an adjusted p-value of 6.609e-05. Which disease is associated with this gene through geno... | Weaver syndrome | Medium | convergence | {"qa_id":"medium_convergence_04261","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Dengue virus are known to upregulate a specific shared gene. Experimental data for this gene in pleural mesothelioma cells (fr... | |
medium_convergence_04262 | Human alphaherpesvirus 3 and Dengue virus both upregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately 1.203 and an adjusted p-value of 0.0001646. Which protein is encoded by this gene? | Zinc finger protein 367 | Medium | convergence | {"qa_id":"medium_convergence_04262","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Dengue virus both upregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports ... | |
medium_convergence_04263 | ANAPC10 and BUB1 both interact with a specific shared protein. Research indicates that this shared protein contains an ABBA motif and binds to the APC/C coactivator. Which protein is encoded by this shared entity? | Cell division cycle protein 20 homolog | Medium | convergence | {"qa_id":"medium_convergence_04263","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC10 and BUB1 both interact with a specific shared protein. Research indicates that this shared protein contains an ABBA motif and binds to the APC/C coac... | |
medium_convergence_04264 | SUPT16H and FANCD2 both interact with a specific shared protein. Experimental evidence indicates that this shared protein interacts directly with minichromosome maintenance (MCM) proteins. Which protein is encoded by this shared entity? | DNA replication licensing factor MCM4 | Medium | convergence | {"qa_id":"medium_convergence_04264","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SUPT16H and FANCD2 both interact with a specific shared protein. Experimental evidence indicates that this shared protein interacts directly with minichromos... | |
medium_convergence_04265 | PSME3 and RACK1 share common interaction partners. One such shared partner is supported by evidence stating: 'The binding of TP beta with alpha 7 and PA28 gamma was confirmed by co-immunoprecipitation and pull-down assays.' Which disease is associated with this specific shared partner? | bleeding disorder, platelet-type, 13, susceptibility to | Medium | convergence | {"qa_id":"medium_convergence_04265","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSME3 and RACK1 share common interaction partners. One such shared partner is supported by evidence stating: 'The binding of TP beta with alpha 7 and PA28 ga... | |
medium_convergence_04266 | PIAS4 and MDC1 both interact with a common protein. Evidence indicates that this protein facilitates the accumulation of checkpoint mediator proteins BRCA1 and 53BP1 at damaged chromatin, partly through phospho-dependent binding via its FHA domain to MDC1. Which disease is associated with this protein as a biomarker? | Fanconi anemia complementation group A | Medium | convergence | {"qa_id":"medium_convergence_04266","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PIAS4 and MDC1 both interact with a common protein. Evidence indicates that this protein facilitates the accumulation of checkpoint mediator proteins BRCA1 a... | |
medium_convergence_04267 | PRKDC and TP53 share multiple interacting partners. One such partner is implicated in a study where a recombinant caspase specifically cleaved the p460 subunit of DNA-PK (purified from Raji cells) into 230- and 160-kDa polypeptides, with the 160-kDa fragment detected in anti-Fas-treated Jurkat cells. Which disease is a... | ovarian cancer | Medium | convergence | {"qa_id":"medium_convergence_04267","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKDC and TP53 share multiple interacting partners. One such partner is implicated in a study where a recombinant caspase specifically cleaved the p460 subun... | |
medium_convergence_04268 | Both West Nile virus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific gene. Experimental data from monocyte-derived dendritic cells (study GSE136342) indicates that for one such shared target, the log2 fold change is approximately 1.205 and the adjusted p-value is 0.01096. Wh... | Tumor necrosis factor-inducible gene 6 protein | Medium | convergence | {"qa_id":"medium_convergence_04268","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific gene. Experimental data from monocyte-deriv... | |
medium_convergence_04271 | PRKACG and AKAP1 share multiple binding partners. One shared partner is described in evidence stating: 'Analysis of ternary complexes by the yeast two-hybrid system revealed that RIalpha and RIbeta homodimers as well as an RIalpha:RIbeta heterodimer and several of the mutants were able to bind to the R-binding domain o... | cAMP-dependent protein kinase type I-beta regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_04271","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKACG and AKAP1 share multiple binding partners. One shared partner is described in evidence stating: 'Analysis of ternary complexes by the yeast two-hybrid... | |
medium_convergence_04272 | TOPBP1 and MYC share multiple interacting partners. One such shared partner directly interacts with c-Myc and stabilizes its protein levels by preventing proteasomal degradation. Which disease is associated with this specific shared partner through genomic alterations? | hypercholesterolemia, familial, 4 | Medium | convergence | {"qa_id":"medium_convergence_04272","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and MYC share multiple interacting partners. One such shared partner directly interacts with c-Myc and stabilizes its protein levels by preventing pro... | |
medium_convergence_04273 | SORBS1 and EGFR both interact with a shared protein. Evidence regarding this shared protein states: 'Using yeast two-hybrid, GST-pulldown, and coimmunoprecipitation studies, we isolated the CAP cDNA as a specific partner of the proline-rich domain of the shared protein and showed by GST-pulldown experiments that the in... | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 | Medium | convergence | {"qa_id":"medium_convergence_04273","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SORBS1 and EGFR both interact with a shared protein. Evidence regarding this shared protein states: 'Using yeast two-hybrid, GST-pulldown, and coimmunoprecip... | |
medium_convergence_04274 | EP300 and KMT2C each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'This enhancement was due to direct protein-protein interactions of both pax-6 and cdx-2 with the N-terminal C/H1 domain of p300.' Which protein is connected to that entity through the 'encodes' relation... | Paired box protein Pax-6 | Medium | convergence | {"qa_id":"medium_convergence_04274","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and KMT2C each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'This enhancement was due to direct prot... | |
medium_convergence_04275 | DAXX and CBX5 both interact with a specific histone protein. Evidence indicates that the histone-binding domain of DAXX binds an H3.3-H4 heterodimer, making extensive contacts with both H3.3 and H4. Which protein is encoded by the gene corresponding to this shared interaction partner? | Histone H3.1 | Medium | convergence | {"qa_id":"medium_convergence_04275","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAXX and CBX5 both interact with a specific histone protein. Evidence indicates that the histone-binding domain of DAXX binds an H3.3-H4 heterodimer, making ... | |
medium_convergence_04276 | Leuprolide and Fluconazole both interact with a specific drug. Evidence regarding co-prescription patterns for Fluconazole indicates that Solifenacin (34.9%), clarithromycin (18.1%), the drug in question (15.1%), and donepezil (10.4%) are frequently co-prescribed. Which disease is the drug in question indicated for? | benign prostatic hyperplasia | Medium | convergence | {"qa_id":"medium_convergence_04276","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Leuprolide and Fluconazole both interact with a specific drug. Evidence regarding co-prescription patterns for Fluconazole indicates that Solifenacin (34.9%)... | |
medium_convergence_04277 | Both YWHAB and YWHAH interact with multiple shared gene products. One such shared partner is distinguished by the finding that 14-3-3 adaptor proteins bind to it, whereas they do not bind to the other three members of the hMex-3 family. Which cellular component is this specific shared partner located in? | P-body | Medium | convergence | {"qa_id":"medium_convergence_04277","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both YWHAB and YWHAH interact with multiple shared gene products. One such shared partner is distinguished by the finding that 14-3-3 adaptor proteins bind t... | |
medium_convergence_04278 | CHEK2 and PPP2R1B share multiple interacting partners. One such partner was identified in a yeast two-hybrid screen where Chk2 was found to associate with the B' regulatory subunit of protein phosphatase PP2A. Which disease is associated with this specific interacting partner? | melanoma | Medium | convergence | {"qa_id":"medium_convergence_04278","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK2 and PPP2R1B share multiple interacting partners. One such partner was identified in a yeast two-hybrid screen where Chk2 was found to associate with th... | |
medium_convergence_04279 | ABI1 and ABI2 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We identified Abl interactor 1 (Abi-1), which is known to interact with c-Abl, as a binding protein for [the shared protein].' Which protein is encoded by this shared entity? | Protein enabled homolog | Medium | convergence | {"qa_id":"medium_convergence_04279","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ABI1 and ABI2 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We identified Abl interactor 1 (Abi-1), which is k... | |
medium_convergence_04280 | EP300 and RARA both interact with a shared protein. Evidence indicates that the coactivator/acetylase p300 interacts with and acetylates the DNA-binding domain (DBD) of this shared entity, thereby activating its transcription. Which protein is encoded by this shared entity? | Krueppel-like factor 5 | Medium | convergence | {"qa_id":"medium_convergence_04280","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and RARA both interact with a shared protein. Evidence indicates that the coactivator/acetylase p300 interacts with and acetylates the DNA-binding doma... | |
medium_convergence_04281 | EP300 and FOXK2 both interact with a specific shared protein. Evidence indicates that this protein, similar to its yeast homologs, interacts with proteins associated with histone acetyltransferase (HAT) activity, such as TRRAP, PCAF, CBP, and p300. Which cellular component is this shared protein located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_04281","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and FOXK2 both interact with a specific shared protein. Evidence indicates that this protein, similar to its yeast homologs, interacts with proteins as... | |
medium_convergence_04282 | Both West Nile virus and Zika virus have been shown to downregulate the expression of a specific gene. Experimental data from monocyte-derived dendritic cells (study GSE136342) indicate that for one such shared target, the log2 fold change is -1.107 and the adjusted p-value is 0.00894. Which disease is associated with ... | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_04282","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Zika virus have been shown to downregulate the expression of a specific gene. Experimental data from monocyte-derived dendritic cell... | |
medium_convergence_04283 | CAND1 and CUL5 each interact with more than one shared protein. Evidence concerning one shared entity reports that it interacts with CUL5 via only two residues, Pro184 and Arg186, which are located in the C-terminal part of the SOCS box called the CUL5 box. Which cell type is that shared entity enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_04283","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAND1 and CUL5 each interact with more than one shared protein. Evidence concerning one shared entity reports that it interacts with CUL5 via only two residu... | |
medium_convergence_04284 | HSP90AA1 and PRKN (PARK2) share multiple protein interaction partners. One such shared partner is described in a study stating: 'In this study, we found that [the shared partner] physically interacts with LAMP-2A, the lysosomal receptor for CMA, and Hsc70 and Hsp90, which can function as components of the CMA pathway.'... | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | Medium | convergence | {"qa_id":"medium_convergence_04284","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and PRKN (PARK2) share multiple protein interaction partners. One such shared partner is described in a study stating: 'In this study, we found that... | |
medium_convergence_04285 | Human alphaherpesvirus 1 and Human orthopneumovirus both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of 1.025 and an adjusted p-value of 0.03435. Which protein is encoded by this gene? | mRNA decay activator protein ZFP36 | Medium | convergence | {"qa_id":"medium_convergence_04285","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human orthopneumovirus both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study... | |
medium_convergence_04286 | Human respirovirus 3 and Enterovirus A both downregulate a specific gene. Evidence for this shared target in non-small cell lung adenocarcinoma cells (study GSE147507) reports a log2 fold change of -1.015 and an adjusted p-value of 0.04216. Which protein is encoded by this gene? | Tribbles homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_04286","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Enterovirus A both downregulate a specific gene. Evidence for this shared target in non-small cell lung adenocarcinoma cells (study ... | |
medium_convergence_04287 | CNOT6L and PABPC1 share a common interaction partner. Evidence indicates that a single amino acid substitution in the PAM2 motif of this shared partner abolishes its interaction with PABPC1. Which protein is encoded by this shared partner? | Trinucleotide repeat-containing gene 6A protein | Medium | convergence | {"qa_id":"medium_convergence_04287","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CNOT6L and PABPC1 share a common interaction partner. Evidence indicates that a single amino acid substitution in the PAM2 motif of this shared partner aboli... | |
medium_convergence_04288 | ESR1 and PML both interact with a specific shared protein. Experimental evidence indicates that for this shared protein, the suppression of ESR1 can be reversed by utilizing an interaction blocker (ER-6, amino acids 312-340) that targets the interaction with a nuclear receptor, suggesting the suppression is due to dire... | Nuclear receptor subfamily 2 group C member 1 | Medium | convergence | {"qa_id":"medium_convergence_04288","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and PML both interact with a specific shared protein. Experimental evidence indicates that for this shared protein, the suppression of ESR1 can be rever... | |
medium_convergence_04289 | PDCD6IP and CHMP4C each interact with more than one shared protein partner. Evidence concerning one such shared entity reports: 'In the yeast two-hybrid assay, HD-PTP showed positive interactions with CHMP4b/Shax1, this shared partner, endophilin A1 and ALG-2 but not with either RabGAPLP or CIN85.' Which protein is enc... | Tumor susceptibility gene 101 protein | Medium | convergence | {"qa_id":"medium_convergence_04289","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PDCD6IP and CHMP4C each interact with more than one shared protein partner. Evidence concerning one such shared entity reports: 'In the yeast two-hybrid assa... | |
medium_convergence_04290 | BOP1 and LAS1L each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We also identified the interaction of this entity with LAS1L and SENP3, components of the MLL1-WDR5 supercomplex involving chromatin remodeling.' Which protein is connected to that entity through the 'encodes... | Proline-, glutamic acid- and leucine-rich protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04290","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BOP1 and LAS1L each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We also identified the interaction of this en... | |
medium_convergence_04291 | NGFR and PRKN share multiple interacting partners. One such shared partner was identified using a peptide-based strategy as a novel signaling adaptor for p75(NTR), with evidence provided for a regulated interaction via S425 phosphorylation. Which protein is encoded by this specific shared partner? | PDZ and LIM domain protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04291","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NGFR and PRKN share multiple interacting partners. One such shared partner was identified using a peptide-based strategy as a novel signaling adaptor for p75... | |
medium_convergence_04292 | Morphine and Triprolidine both interact with a specific drug. Clinical evidence regarding this drug indicates that in the treatment group, cumulative morphine consumption from 0 to 48 hours postoperatively was lower (11 mg [5 to 21] versus 6 mg [0 to 17]) and the incidence of postoperative nausea and vomiting was reduc... | anxiety | Medium | convergence | {"qa_id":"medium_convergence_04292","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Morphine and Triprolidine both interact with a specific drug. Clinical evidence regarding this drug indicates that in the treatment group, cumulative morphin... | |
medium_convergence_04293 | CREBBP and E2F1 share common interaction partners. One such shared partner is a transcription factor involved in the G1/S transition, with interaction evidence supported by Co-IP analysis. Which protein is encoded by this shared partner? | Transcription factor E2F3 | Medium | convergence | {"qa_id":"medium_convergence_04293","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and E2F1 share common interaction partners. One such shared partner is a transcription factor involved in the G1/S transition, with interaction eviden... | |
medium_convergence_04294 | EME1 and MUS81 both interact with a specific shared protein. Evidence indicates that this shared protein forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases. Additionally, it associates with the MSH2/MSH3 mismatch repair complex, the telomere binding complex TERF2(TRF2)-TERF2IP(RA... | Structure-specific endonuclease subunit SLX4 | Medium | convergence | {"qa_id":"medium_convergence_04294","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EME1 and MUS81 both interact with a specific shared protein. Evidence indicates that this shared protein forms a multiprotein complex with the ERCC4(XPF)-ERC... | |
medium_convergence_04295 | E2F1 and BRF1 share a common interaction partner. Evidence regarding this shared partner states: 'We now demonstrate that this complex contains the Rb-related protein encoded by the shared partner.' Which protein is encoded by this shared interaction partner? | Retinoblastoma-like protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04295","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"E2F1 and BRF1 share a common interaction partner. Evidence regarding this shared partner states: 'We now demonstrate that this complex contains the Rb-relate... | |
medium_convergence_04296 | Both alphaA-crystallin (CRYAA) and alphaB-crystallin (CRYAB) interact with a specific beta-crystallin protein. Experimental evidence indicates that motifs III and IV of this beta-crystallin interact with alphaA-crystallin, while motifs II and III primarily interact with alphaB-crystallin. Which gene encodes this specif... | Beta-crystallin A3 | Medium | convergence | {"qa_id":"medium_convergence_04296","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both alphaA-crystallin (CRYAA) and alphaB-crystallin (CRYAB) interact with a specific beta-crystallin protein. Experimental evidence indicates that motifs II... | |
medium_convergence_04297 | HDAC3 and NCOR1 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Here we show that LXRs interact with corepressors, N-CoR (nuclear receptor corepressor) and SMRT (silent mediator of retinoic acid receptor and thyroid receptor), which are released upon binding agonists... | Oxysterols receptor LXR-alpha | Medium | convergence | {"qa_id":"medium_convergence_04297","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC3 and NCOR1 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Here we show that LXRs interact with cor... | |
medium_convergence_04298 | PARP1 and FANCD2 share a common interacting partner. Evidence indicates that this shared entity is a central player in the choice of DNA repair pathway, and that both hypo-H3K27me2/3 and H3.1K27M interact with it. Which disease is connected to this entity through genomic alterations? | adult medulloblastoma | Medium | convergence | {"qa_id":"medium_convergence_04298","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and FANCD2 share a common interacting partner. Evidence indicates that this shared entity is a central player in the choice of DNA repair pathway, and ... |
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