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medium_convergence_04075 | ACTR3 and AP2S1 both interact with a common protein partner. Evidence regarding this shared partner indicates that its NTA region interacts directly with the Arp2/3 complex, as demonstrated by affinity chromatography, immunoprecipitation assays, and binding assays using purified components. Which protein is encoded by ... | Src substrate cortactin | Medium | convergence | {"qa_id":"medium_convergence_04075","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR3 and AP2S1 both interact with a common protein partner. Evidence regarding this shared partner indicates that its NTA region interacts directly with the... | |
medium_convergence_04076 | CENPK and CENPH both interact with a shared protein partner. Evidence regarding this partner states: 'We found that the MID-MHF complex consists of one histone H3-H4-like MHF heterotetramer wrapped by a single polypeptide of MID.' Which protein is encoded by this shared partner? | Centromere protein S | Medium | convergence | {"qa_id":"medium_convergence_04076","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPK and CENPH both interact with a shared protein partner. Evidence regarding this partner states: 'We found that the MID-MHF complex consists of one histo... | |
medium_convergence_04077 | DNAJA2 and MYC both interact with a specific shared protein. Evidence indicates that this shared protein attenuates FBXW7-mediated ubiquitination and degradation of MYC by directly binding to the MYC homology box 1 domain, competing with FBXW7. Which protein is encoded by this shared entity? | DNA polymerase delta catalytic subunit | Medium | convergence | {"qa_id":"medium_convergence_04077","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNAJA2 and MYC both interact with a specific shared protein. Evidence indicates that this shared protein attenuates FBXW7-mediated ubiquitination and degrada... | |
medium_convergence_04078 | RAD50 and MDC1 both interact with a shared protein. Evidence regarding this shared protein states: 'This effect is dependent on a direct interaction between MRN and the tandem breast cancer carboxy-terminal (BRCT) repeats in this protein, and is accompanied by hyper-phosphorylation of both Nbs1 and this protein.' Which... | glioblastoma | Medium | convergence | {"qa_id":"medium_convergence_04078","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD50 and MDC1 both interact with a shared protein. Evidence regarding this shared protein states: 'This effect is dependent on a direct interaction between ... | |
medium_convergence_04079 | EIF3D and EIF3J share multiple binding partners. One such partner is described by the evidence: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which protein, encoded by the gene corresponding to this specific shared partner, is the target of the 'encodes' relationship? | Eukaryotic translation initiation factor 3 subunit M | Medium | convergence | {"qa_id":"medium_convergence_04079","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3D and EIF3J share multiple binding partners. One such partner is described by the evidence: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impair... | |
medium_convergence_04080 | Both MAX and MYC interact with multiple shared partners. One such shared partner is described in the following evidence: 'Here we show that c-Myc binds NF-Y subunits, YB and YC, by immunoprecipitation from cotransfected COS-1 cells.' Which protein is encoded by the specific NF-Y subunit mentioned in this evidence that ... | Nuclear transcription factor Y subunit beta | Medium | convergence | {"qa_id":"medium_convergence_04080","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both MAX and MYC interact with multiple shared partners. One such shared partner is described in the following evidence: 'Here we show that c-Myc binds NF-Y ... | |
medium_convergence_04082 | HOXB1 and MEIS1 both interact with a common protein partner. Experimental evidence indicates the formation of a ternary complex consisting of Prep1, this shared partner, and HOXB1 on a HOXB1-responsive target in vitro. Which protein is encoded by the gene corresponding to this shared partner? | Pre-B-cell leukemia transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_04082","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HOXB1 and MEIS1 both interact with a common protein partner. Experimental evidence indicates the formation of a ternary complex consisting of Prep1, this sha... | |
medium_convergence_04083 | GSK3B and PRKN share multiple interacting partners. One such shared partner is implicated in a mechanism where PARK2 mutations in cancer reduce E3 ligase activity, thereby impairing the ubiquitination of cyclin E and causing mitotic instability. Which protein is encoded by this specific shared partner? | G1/S-specific cyclin-E1 | Medium | convergence | {"qa_id":"medium_convergence_04083","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GSK3B and PRKN share multiple interacting partners. One such shared partner is implicated in a mechanism where PARK2 mutations in cancer reduce E3 ligase act... | |
medium_convergence_04084 | Human betaherpesvirus 5 and Human respirovirus 3 both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of -1.238 and an adjusted p-value of 4.537e-06. Which protein is encoded by this gene? | Tribbles homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_04084","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human respirovirus 3 both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports... | |
medium_convergence_04085 | ARPC2 and BAIAP2 each interact with more than one shared protein. Evidence concerning one of these shared proteins indicates that the carboxy-terminal Src-homology-3 domain of IRSp53 binds to WAVE to form a trimolecular complex. Which disease is associated with that specific shared protein? | preeclampsia | Medium | convergence | {"qa_id":"medium_convergence_04085","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC2 and BAIAP2 each interact with more than one shared protein. Evidence concerning one of these shared proteins indicates that the carboxy-terminal Src-ho... | |
medium_convergence_04087 | ATG12 and IKBKE each interact with more than one shared protein. Evidence concerning one of these shared proteins states: 'We have previously shown that this protein recruits IkappaB kinase epsilon (IKKepsilon) but not TBK-1 to the mitochondria following viral infection.' Which disease is associated with that specific ... | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04087","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATG12 and IKBKE each interact with more than one shared protein. Evidence concerning one of these shared proteins states: 'We have previously shown that this... | |
medium_convergence_04088 | Both 'regulation of antimicrobial humoral response' and 'regulation of innate immune response' are subtypes of a common biological process. Evidence for one such shared parent process states: 'Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response.' Which biological process is di... | response to biotic stimulus | Medium | convergence | {"qa_id":"medium_convergence_04088","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both 'regulation of antimicrobial humoral response' and 'regulation of innate immune response' are subtypes of a common biological process. Evidence for one ... | |
medium_convergence_04089 | GNAI2 and ARRB2 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'In vitro data from glutathione-S-transferase pull-down assay showed that the carboxyl terminus (CT) and the third intracellular loop (I3L) of DOR are both capable of and either domain is sufficient for binding ... | gastric carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04089","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI2 and ARRB2 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'In vitro data from glutathione-S-transferase pu... | |
medium_convergence_04090 | CBX3 and CBX5 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'In a yeast two-hybrid screen, the nucleoplasmic domain of a specific inner nuclear membrane integral protein, associated with two human polypeptides homologous to Drosophila HP1, a heterochromatin protein... | Delta(14)-sterol reductase LBR | Medium | convergence | {"qa_id":"medium_convergence_04090","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and CBX5 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'In a yeast two-hybrid screen, the nucleop... | |
medium_convergence_04091 | Both Enterovirus A and Cardiovirus A are reported to upregulate a specific gene. In a study of rhabdomyosarcoma cells (GSE103308), this gene exhibited a log2 fold change of approximately 2.156 and an adjusted p-value of 0.0127. Which cellular component is this gene located in? | extracellular space | Medium | convergence | {"qa_id":"medium_convergence_04091","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Enterovirus A and Cardiovirus A are reported to upregulate a specific gene. In a study of rhabdomyosarcoma cells (GSE103308), this gene exhibited a log2... | |
medium_convergence_04092 | MAP3K2 and MAP3K3 share common interaction partners. One such shared partner has been shown to specifically interact with MEKK3 and potentiate MEKK3-mediated AP1 and CHOP activation. Which protein is encoded by this shared partner? | E3 ubiquitin-protein ligase TRAF7 | Medium | convergence | {"qa_id":"medium_convergence_04092","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAP3K2 and MAP3K3 share common interaction partners. One such shared partner has been shown to specifically interact with MEKK3 and potentiate MEKK3-mediated... | |
medium_convergence_04093 | HDAC1 and MDM2 share multiple interacting partners. One such partner is implicated in a study demonstrating an interaction between Snail, histone deacetylase 1 (HDAC1), HDAC2, and the corepressor mSin3A. Which protein is encoded by this shared interacting partner? | Zinc finger protein SNAI2 | Medium | convergence | {"qa_id":"medium_convergence_04093","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and MDM2 share multiple interacting partners. One such partner is implicated in a study demonstrating an interaction between Snail, histone deacetylase... | |
medium_convergence_04094 | AP2S1 and CLTC both interact with a shared protein. Evidence indicates that in vitro binding and coimmunoprecipitation demonstrated that the clathrin heavy chain is the major binding partner of this shared protein. Which disease is associated with this shared protein as a biomarker? | paroxysmal familial ventricular fibrillation | Medium | convergence | {"qa_id":"medium_convergence_04094","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP2S1 and CLTC both interact with a shared protein. Evidence indicates that in vitro binding and coimmunoprecipitation demonstrated that the clathrin heavy c... | |
medium_convergence_04095 | CDKN1B and CHEK1 both interact with a shared protein. Evidence states: 'Here, we identify damaged DNA-binding protein 1 as a novel Chk1-interacting protein.' Which gene encodes this shared protein? | DNA damage-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04095","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN1B and CHEK1 both interact with a shared protein. Evidence states: 'Here, we identify damaged DNA-binding protein 1 as a novel Chk1-interacting protein.'... | |
medium_convergence_04096 | Cyclosporine and Vemurafenib both interact with a specific shared drug. Evidence regarding this shared drug notes that pharmacokinetic parameters changed, albeit not significantly, before and after ART, specifically for cyclosporine A (Cmax -64%, Cmin +14%, AUC -47%; n = 2). Which disease is this shared drug indicated ... | HIV infectious disease | Medium | convergence | {"qa_id":"medium_convergence_04096","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cyclosporine and Vemurafenib both interact with a specific shared drug. Evidence regarding this shared drug notes that pharmacokinetic parameters changed, al... | |
medium_convergence_04097 | DOK1 and EGFR share common interacting partners. One such shared partner is described in a report stating: 'We now report that this protein associates with Dok1, a protein that interacts with Ras-GAP, Csk, and Nck.' Which disease is connected to this shared partner through a biomarker relationship? | pneumonia | Medium | convergence | {"qa_id":"medium_convergence_04097","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DOK1 and EGFR share common interacting partners. One such shared partner is described in a report stating: 'We now report that this protein associates with D... | |
medium_convergence_04098 | CEBPA and E2F1 share a common interaction partner. Evidence indicates that the human G1 phase regulator [shared interaction partner] associates with both activator (E2F1 and E2F3a) and repressor (E2F4) E2F proteins, a property conserved in insect cells. Which protein is encoded by the gene corresponding to this shared ... | Host cell factor 1 | Medium | convergence | {"qa_id":"medium_convergence_04098","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPA and E2F1 share a common interaction partner. Evidence indicates that the human G1 phase regulator [shared interaction partner] associates with both act... | |
medium_convergence_04099 | VPS28 and MVB12B both interact with a common protein partner. Evidence regarding this partner indicates that ESCRT-II binds to the ESCRT-I VPS28 C-terminal domain subunit through a helix located immediately C-terminal to the partner's GLUE domain. Which cell type is this partner enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_04099","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VPS28 and MVB12B both interact with a common protein partner. Evidence regarding this partner indicates that ESCRT-II binds to the ESCRT-I VPS28 C-terminal d... | |
medium_convergence_04100 | Both Human orthopneumovirus and Human immunodeficiency virus 1 are reported to upregulate a specific gene. Evidence for this shared target in cytotoxic T-lymphocytes (from study GSE106475) indicates a log2 fold change of approximately 1.36 and an adjusted p-value of approximately 0.041. What is the name of the protein ... | Cbp/p300-interacting transactivator 2 | Medium | convergence | {"qa_id":"medium_convergence_04100","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Human immunodeficiency virus 1 are reported to upregulate a specific gene. Evidence for this shared target in cytotoxic T-lym... | |
medium_convergence_04101 | LAMTOR2 and LAMTOR3 both interact with a shared protein. Evidence regarding this shared protein states: 'In a two-hybrid screen with p14 as a bait, we identified the mitogen-activated protein kinase (MAPK) scaffolding protein MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) partner 1 (MP1) as an interactin... | Dual specificity mitogen-activated protein kinase kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_04101","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMTOR2 and LAMTOR3 both interact with a shared protein. Evidence regarding this shared protein states: 'In a two-hybrid screen with p14 as a bait, we identi... | |
medium_convergence_04102 | BIRC2 and TRAF3 share a common interaction partner. Evidence regarding this partner states: 'Similarly to XIAP, in vitro binding experiments indicated that c-IAP-1 and c-IAP-2 bound specifically to the terminal effector cell death proteases, caspases-3 and -7, but not to the proximal protease caspase-8, caspases-1 or -... | ovarian cancer | Medium | convergence | {"qa_id":"medium_convergence_04102","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and TRAF3 share a common interaction partner. Evidence regarding this partner states: 'Similarly to XIAP, in vitro binding experiments indicated that c... | |
medium_convergence_04103 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line (study GSE100576) reports a log2 fold change of approximately 1.555 and an adjusted p-value of 0.04968. Which protein is encoded by this gene? | UMP-CMP kinase 2, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_04103","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line (stu... | |
medium_convergence_04104 | PARP1 and HDAC2 share multiple interacting partners. One such partner is described in evidence stating: 'Mechanistic analysis further showed that it specifically interacts with poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme important in DNA repair and apoptosis.' Which protein is encoded by this specific shar... | Krueppel-like factor 5 | Medium | convergence | {"qa_id":"medium_convergence_04104","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and HDAC2 share multiple interacting partners. One such partner is described in evidence stating: 'Mechanistic analysis further showed that it specific... | |
medium_convergence_04105 | Human alphaherpesvirus 1 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately -1.23 and an adjusted p-value of approximately 0.0037. Which disease is associated with this gene? | prostate adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_04105","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE11496... | |
medium_convergence_04106 | GTF2H4 and MLLT1 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'Consistent with earlier purifications of ENL and AF4 from 293 cells, the 90 amino acid C-terminal domain of this gene associates with many other MLL translocation partners including Enl, Af4, Laf4, Af5q31, Ell... | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_04106","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2H4 and MLLT1 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'Consistent with earlier purifications of ENL a... | |
medium_convergence_04107 | Both Measles morbillivirus and Dengue virus are known to downregulate a specific host gene. Experimental data for this gene from study GSE131840 indicates a log2 fold change of -1.338 and an adjusted p-value of 0.01857. What molecular function is enabled by this gene? | RNA binding | Medium | convergence | {"qa_id":"medium_convergence_04107","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Dengue virus are known to downregulate a specific host gene. Experimental data for this gene from study GSE131840 indicates a ... | |
medium_convergence_04108 | AGR2 and MDM2 share common interaction partners. One such shared partner is described by the following mechanism: it binds to the acidic domain of MDM2, thereby inhibiting MDM2-mediated p53 ubiquitination and degradation, which extends the half-life of p53. Which disease is associated with this specific shared partner ... | T-cell non-Hodgkin lymphoma | Medium | convergence | {"qa_id":"medium_convergence_04108","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AGR2 and MDM2 share common interaction partners. One such shared partner is described by the following mechanism: it binds to the acidic domain of MDM2, ther... | |
medium_convergence_04110 | EP300 and NFKB2 share a common interaction partner. Evidence indicates that histone acetyltransferase p300 enhances the transactivation induced by this shared entity and interacts with it both in vitro and in cells transformed by this entity, specifically chicken spleen cells and the B-lymphoma cell line RC-K8, where t... | naive B cell | Medium | convergence | {"qa_id":"medium_convergence_04110","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and NFKB2 share a common interaction partner. Evidence indicates that histone acetyltransferase p300 enhances the transactivation induced by this share... | |
medium_convergence_04112 | PIAS3 and DOCK9 both interact with a specific shared protein. Experimental evidence indicates that PIAS3 interacts with Smad proteins, with the strongest interaction observed with this specific shared entity. Which gene encodes this protein? | SMAD family member 3 | Medium | convergence | {"qa_id":"medium_convergence_04112","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PIAS3 and DOCK9 both interact with a specific shared protein. Experimental evidence indicates that PIAS3 interacts with Smad proteins, with the strongest int... | |
medium_convergence_04113 | Human betaherpesvirus 5 and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE132081) reports a log2 fold change of -1.608 and an adjusted p-value of 0.003501. Which protein is encoded by this gene? | Adenosine receptor A2b | Medium | convergence | {"qa_id":"medium_convergence_04113","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE1... | |
medium_convergence_04114 | Both Dengue virus and Enterovirus A are reported to upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold change of approximately 2.05 and an adjusted p-value of 0.001099. Which protein is encoded by this gene? | Basic leucine zipper transcriptional factor ATF-like 3 | Medium | convergence | {"qa_id":"medium_convergence_04114","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Dengue virus and Enterovirus A are reported to upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) sho... | |
medium_convergence_04115 | DBF4 and CLSPN both interact with a shared protein. Evidence regarding this shared protein states: 'We also identified an interaction between MCM-BP and the Dbf4 regulatory component of the DDK kinase in both yeast 2-hybrid and insect cell co-expression assays, and this interaction was verified by co-immunoprecipitatio... | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04115","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DBF4 and CLSPN both interact with a shared protein. Evidence regarding this shared protein states: 'We also identified an interaction between MCM-BP and the ... | |
medium_convergence_04116 | CDC23 and CDC20 each share a binding partner with another gene. Evidence concerning one such shared partner states: 'In extracts prepared from M phase, but not from interphase HeLa cells, p55CDC coimmunoprecipitates with three important elements of the M phase checkpoint machinery: this shared partner, Cdc16, and Mad2.... | CDH1 | Medium | convergence | {"qa_id":"medium_convergence_04116","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC23 and CDC20 each share a binding partner with another gene. Evidence concerning one such shared partner states: 'In extracts prepared from M phase, but n... | |
medium_convergence_04117 | Both the Lyme disease vaccine (recombinant OspA) and Bleomycin share interactions with a specific drug. Evidence regarding this shared drug indicates that synergism between the drugs when administered concurrently produces pulmonary toxicity at lower doses. Which disease is this shared drug indicated for? | lymphosarcoma | Medium | convergence | {"qa_id":"medium_convergence_04117","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the Lyme disease vaccine (recombinant OspA) and Bleomycin share interactions with a specific drug. Evidence regarding this shared drug indicates that sy... | |
medium_convergence_04118 | Both Human respirovirus 3 and Human immunodeficiency virus 1 are reported to upregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) shows a log2 fold change of approximately 1.896 and an adjusted p-value of 0.04844. Which protein is encoded by thi... | Interleukin-6 | Medium | convergence | {"qa_id":"medium_convergence_04118","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Human immunodeficiency virus 1 are reported to upregulate a specific gene. Experimental data for this gene in a non-small cell ... | |
medium_convergence_04120 | TRIM28 and ETV4 both interact with a specific shared protein. Evidence indicates that this protein interacts with KSHV latency-associated nuclear antigen 1 (LANA-1) and the host transcriptional repressor KAP1, and that these interactions contribute to the repression of lytic gene expression. Which protein is encoded by... | Nuclear factor erythroid 2-related factor 2 | Medium | convergence | {"qa_id":"medium_convergence_04120","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and ETV4 both interact with a specific shared protein. Evidence indicates that this protein interacts with KSHV latency-associated nuclear antigen 1 (... | |
medium_convergence_04121 | Enterovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene in a particular study reports a log2 fold change of approximately 3.795 and an adjusted p-value of approximately 0.0006776. Which cell type is this gene enriched in? | gamma-delta T cell | Medium | convergence | {"qa_id":"medium_convergence_04121","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene in a particular study reports a log2 fold change of approximately 3.7... | |
medium_convergence_04123 | CSNK2A1 and CSNK2B each interact with more than one shared gene. Evidence concerning one shared entity reports: 'We demonstrate here that the Ring-H2 finger-disrupted mutant of this shared entity does not interact with purified CKIIbeta in vitro, which shows that the Ring-H2 finger motif is critical for direct interact... | CDC34 | Medium | convergence | {"qa_id":"medium_convergence_04123","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and CSNK2B each interact with more than one shared gene. Evidence concerning one shared entity reports: 'We demonstrate here that the Ring-H2 finger-... | |
medium_convergence_04124 | MTCH1 and PRKN share common interaction partners. Evidence indicates that Parkinson's disease-causing mutations in PARK2 disrupt its molecular interaction with specific TOMM complex subunits, including the surface receptor, a specific shared entity, and the channel protein TOMM40. Which protein is encoded by that speci... | Mitochondrial import receptor subunit TOM70 | Medium | convergence | {"qa_id":"medium_convergence_04124","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MTCH1 and PRKN share common interaction partners. Evidence indicates that Parkinson's disease-causing mutations in PARK2 disrupt its molecular interaction wi... | |
medium_convergence_04125 | CHEK2 and AR share multiple interaction partners. One specific shared partner is identified in a study as a ubiquitin E3 ligase that interacts with CHEK2, mediating its ubiquitination and proteasomal degradation. Which disease is associated with this specific shared partner? | cerebral infarction | Medium | convergence | {"qa_id":"medium_convergence_04125","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK2 and AR share multiple interaction partners. One specific shared partner is identified in a study as a ubiquitin E3 ligase that interacts with CHEK2, me... | |
medium_convergence_04126 | ATM and BRCA1 both interact with a specific shared protein partner. Evidence indicates that a specific partner protein interacts specifically with the BRCT repeats of this shared entity, both in vitro and in vivo, and that tumor-derived mutations in this region abolish these interactions. Which protein is encoded by th... | DNA endonuclease RBBP8 | Medium | convergence | {"qa_id":"medium_convergence_04126","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and BRCA1 both interact with a specific shared protein partner. Evidence indicates that a specific partner protein interacts specifically with the BRCT r... | |
medium_convergence_04127 | Both Human alphaherpesvirus 3 and Cardiovirus A are associated with the downregulation of a specific gene. In a study of melanoma cell lines (GSE136586), this gene exhibited a log2 fold change of -2.080 and an adjusted p-value of 1.198e-06. Which protein is encoded by this gene? | Forkhead box protein Q1 | Medium | convergence | {"qa_id":"medium_convergence_04127","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Cardiovirus A are associated with the downregulation of a specific gene. In a study of melanoma cell lines (GSE136586), thi... | |
medium_convergence_04129 | Human gammaherpesvirus 4 and Zika virus both downregulate a specific gene. Experimental data for this gene in gamma delta T-lymphocytes (from study GSE13906) shows a log2 fold change of -1.092 and an adjusted p-value of 0.03107. Which disease is associated with this gene as a biomarker? | Charcot-Marie-Tooth disease | Medium | convergence | {"qa_id":"medium_convergence_04129","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human gammaherpesvirus 4 and Zika virus both downregulate a specific gene. Experimental data for this gene in gamma delta T-lymphocytes (from study GSE13906)... | |
medium_convergence_04130 | FANCA and FANCB both interact with a specific protein that links Fanconi anemia proteins to the Notch1 developmental pathway via a direct protein-protein interaction with the FA core complex. This protein is identified as hairy enhancer of split 1. Which protein product is encoded by this gene? | Transcription factor HES-1 | Medium | convergence | {"qa_id":"medium_convergence_04130","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCA and FANCB both interact with a specific protein that links Fanconi anemia proteins to the Notch1 developmental pathway via a direct protein-protein int... | |
medium_convergence_04131 | EME1 and CENPS both interact with a common protein. Biochemical evidence indicates that MHF1 and MHF2 form a heterodimer that binds DNA and enhances the DNA branch migration activity of this shared protein. Which gene interacts with this shared protein? | TELO2 | Medium | convergence | {"qa_id":"medium_convergence_04131","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EME1 and CENPS both interact with a common protein. Biochemical evidence indicates that MHF1 and MHF2 form a heterodimer that binds DNA and enhances the DNA ... | |
medium_convergence_04132 | Both Influenza A virus and Orthohepevirus A are known to upregulate a specific shared gene. Experimental data from a study on non-small cell lung adenocarcinoma cell lines (GSE147507) indicates that this gene exhibits a log2 fold change of approximately 1.889 and an adjusted p-value of 1.103e-11. Which disease is assoc... | lymphoid leukemia | Medium | convergence | {"qa_id":"medium_convergence_04132","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Orthohepevirus A are known to upregulate a specific shared gene. Experimental data from a study on non-small cell lung adenocarcin... | |
medium_convergence_04133 | MCM6 and MCM7 each interact with more than one shared protein. Evidence concerning one such shared entity reports that it directly interacts with MCM2, MCM3, MCM6, and MCM7 in JeKo cells. Which protein is encoded by the gene corresponding to that entity? | ATR-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_04133","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM6 and MCM7 each interact with more than one shared protein. Evidence concerning one such shared entity reports that it directly interacts with MCM2, MCM3,... | |
medium_convergence_04134 | Rhinovirus A and Zika virus both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.22 and an adjusted p-value of approximately 0.01. Which disease is associated with this gene as a biomarker? | idiopathic pulmonary fibrosis | Medium | convergence | {"qa_id":"medium_convergence_04134","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold cha... | |
medium_convergence_04135 | HDAC10 and NCOR2 both interact with a shared protein. Evidence regarding this shared protein states: 'In mammalian and yeast two-hybrid assays, these mutations were also associated with a loss of transcriptional repression mediated by the shared protein and a severely impaired interaction with the corepressors SMRT and... | Recombining binding protein suppressor of hairless | Medium | convergence | {"qa_id":"medium_convergence_04135","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC10 and NCOR2 both interact with a shared protein. Evidence regarding this shared protein states: 'In mammalian and yeast two-hybrid assays, these mutatio... | |
medium_convergence_04136 | MIR145 and MIR29B1 are both involved in more than one shared biological process. Evidence concerning one of these shared entities states: 'These data demonstrate a specific role for miR145 in the regulation of matrix gene expression in smooth muscle cells and suggest that miR145 acts to suppress TGFβ-dependent extracel... | extracellular matrix assembly | Medium | convergence | {"qa_id":"medium_convergence_04136","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MIR145 and MIR29B1 are both involved in more than one shared biological process. Evidence concerning one of these shared entities states: 'These data demonst... | |
medium_convergence_04137 | CTBP2 and NFIA both interact with a specific protein. Evidence regarding this shared interaction partner states: 'We show here that [REDACTED] also recruits the four and a half LIM domain protein FHL3.' Which protein is encoded by this shared interaction partner? | Krueppel-like factor 3 | Medium | convergence | {"qa_id":"medium_convergence_04137","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP2 and NFIA both interact with a specific protein. Evidence regarding this shared interaction partner states: 'We show here that [REDACTED] also recruits ... | |
medium_convergence_04138 | Both West Nile virus and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data for this gene, derived from monocyte-derived dendritic cells in study GSE136342, reports a log2 fold change of approximately 1.264 and an adjusted p-value of 0.01457. Which protein is encoded by thi... | Ubiquitin-like protein ISG15 | Medium | convergence | {"qa_id":"medium_convergence_04138","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data for this gene, derived from monocyt... | |
medium_convergence_04139 | EP300 and ESR1 both interact with a shared protein entity. Evidence regarding this entity states: 'We have characterized a novel nuclear protein, [shared entity], that specifically interacts in vitro with this domain of the estrogen receptor.' Which protein is encoded by the gene corresponding to this shared entity? | Nuclear receptor-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04139","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and ESR1 both interact with a shared protein entity. Evidence regarding this entity states: 'We have characterized a novel nuclear protein, [shared ent... | |
medium_convergence_04140 | EP300 and PIN1 share multiple interacting partners. One such shared partner is described by the following mechanism: it physically interacts with PIN1 to trigger K63-linked ubiquitination-dependent stabilization of PIN1, which consequently hyperactivates the PI3K/AKT signaling axis. Which protein is encoded by this sha... | Zinc finger MIZ domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04140","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and PIN1 share multiple interacting partners. One such shared partner is described by the following mechanism: it physically interacts with PIN1 to tri... | |
medium_convergence_04141 | Leuprolide and Oxytocin both interact with a specific drug. Evidence indicates that the co-administration of a sub-effective dose of Leuprolide (50 or 100 microg/kg, s.c.) and this shared drug (0.15 or 0.5 mg/kg, i.p.) similarly inhibited conditioned avoidance response (CAR) and induced catalepsy. Which disease is this... | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_04141","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Leuprolide and Oxytocin both interact with a specific drug. Evidence indicates that the co-administration of a sub-effective dose of Leuprolide (50 or 100 mi... | |
medium_convergence_04142 | CLP1 and TSEN2 both interact with a shared protein complex component. Evidence regarding this component states: 'This enzyme consists of HsSen2, HsSen34, HsSen15, and HsSen54, homologs of the yeast tRNA endonuclease subunits.' Which protein, encoded by the gene corresponding to this component, is the target of the 'enc... | tRNA-splicing endonuclease subunit Sen34 | Medium | convergence | {"qa_id":"medium_convergence_04142","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLP1 and TSEN2 both interact with a shared protein complex component. Evidence regarding this component states: 'This enzyme consists of HsSen2, HsSen34, HsS... | |
medium_convergence_04143 | Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE132081) shows a log2 fold change of approximately -3.24 and an adjusted p-value of 0.0037. Which protein is encoded by this gene? | C-C motif chemokine 2 | Medium | convergence | {"qa_id":"medium_convergence_04143","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE13208... | |
medium_convergence_04144 | Cyproheptadine and Brompheniramine both interact with a specific shared drug. Evidence indicates that the anticataleptic effect of L-DOPA or this shared drug was potentiated by Cyproheptadine. Which disease is this shared drug indicated for? | swine influenza | Medium | convergence | {"qa_id":"medium_convergence_04144","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cyproheptadine and Brompheniramine both interact with a specific shared drug. Evidence indicates that the anticataleptic effect of L-DOPA or this shared drug... | |
medium_convergence_04145 | MAPK8IP3 and ARRB2 share a common interaction partner. Evidence regarding this shared partner states: 'In similar cotransfection studies, JSAP1 also interacted with a MAPKK and MEKK1 MAPKKK, which are involved in the JNK cascades.' Which protein is encoded by this shared interaction partner? | Dual specificity mitogen-activated protein kinase kinase 4 | Medium | convergence | {"qa_id":"medium_convergence_04145","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK8IP3 and ARRB2 share a common interaction partner. Evidence regarding this shared partner states: 'In similar cotransfection studies, JSAP1 also interact... | |
medium_convergence_04146 | NEDD4 and YWHAZ both interact with a specific shared protein. Evidence indicates that this shared protein is identified as an IRS-2 ubiquitin ligase. Which gene encodes this shared protein? | Insulin receptor substrate 2 | Medium | convergence | {"qa_id":"medium_convergence_04146","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4 and YWHAZ both interact with a specific shared protein. Evidence indicates that this shared protein is identified as an IRS-2 ubiquitin ligase. Which g... | |
medium_convergence_04147 | GNAI1 and GNAQ both interact with a specific protein. Evidence for this protein states: 'Consistent with its activity in in vitro GTPase-activating protein assays, the protein interacts efficiently with endogenous proteins of the Gi and Gq subclasses of Galpha subunits but not with G12alpha or Gsalpha.' Which disease i... | schizoaffective disorder | Medium | convergence | {"qa_id":"medium_convergence_04147","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI1 and GNAQ both interact with a specific protein. Evidence for this protein states: 'Consistent with its activity in in vitro GTPase-activating protein a... | |
medium_convergence_04148 | EP300 and HDAC1 both interact with a specific nuclear receptor. Evidence indicates that a ternary complex consisting of this receptor, p65/RelA, and HDAC1 is formed in vivo. Which protein is encoded by the gene corresponding to this receptor? | Peroxisome proliferator-activated receptor delta | Medium | convergence | {"qa_id":"medium_convergence_04148","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and HDAC1 both interact with a specific nuclear receptor. Evidence indicates that a ternary complex consisting of this receptor, p65/RelA, and HDAC1 is... | |
medium_convergence_04150 | Butalbital and Phenytoin both interact with a specific drug. Evidence indicates that the bioavailability of this drug is markedly reduced when administered jointly with antiepileptics or corticosteroids, specifically carbamazepine, phenytoin, or dexamethasone. Which disease is this drug indicated for? | schistosomiasis | Medium | convergence | {"qa_id":"medium_convergence_04150","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Butalbital and Phenytoin both interact with a specific drug. Evidence indicates that the bioavailability of this drug is markedly reduced when administered j... | |
medium_convergence_04151 | Vaccinia virus and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.848 and an adjusted p-value of approximately 0.03565. In which cellular component is the protein product of this g... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_04151","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238... | |
medium_convergence_04152 | FES and GRB2 both interact with a common protein target. Experimental evidence indicates that the binding of GRB2 to this target is strictly dependent on intact phosphorylation sites Y703 and Y936. Which protein is encoded by the gene corresponding to this shared target? | Mast/stem cell growth factor receptor Kit | Medium | convergence | {"qa_id":"medium_convergence_04152","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FES and GRB2 both interact with a common protein target. Experimental evidence indicates that the binding of GRB2 to this target is strictly dependent on int... | |
medium_convergence_04153 | ARCN1 and CAPZA1 both interact with a shared protein. Experimental evidence for this shared protein includes immunoprecipitation and two-hybrid system analysis within a complete COP screen, demonstrating physical interactions between alpha- and epsilon-COPs, as well as between beta- and delta-COPs. Which disease is ass... | Baralle-Macken syndrome | Medium | convergence | {"qa_id":"medium_convergence_04153","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARCN1 and CAPZA1 both interact with a shared protein. Experimental evidence for this shared protein includes immunoprecipitation and two-hybrid system analys... | |
medium_convergence_04154 | HRAS and RAC1 share common interaction partners. One such partner is distinguished by evidence showing it specifically interacts with both dominant-negative and nucleotide-free forms of H-Ras and N-Ras, but not with their corresponding oncogenic forms. Which cell type is enriched for this specific interaction partner? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_04154","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HRAS and RAC1 share common interaction partners. One such partner is distinguished by evidence showing it specifically interacts with both dominant-negative ... | |
medium_convergence_04155 | PRMT5 and KDM1A share common interaction partners. One such partner is involved in a process where, in murine primordial germ cells, its interaction with a transcriptional repressor leads to the arginine 3 dimethylation of histones H2A and H4. Which protein is encoded by this shared interaction partner? | PR domain zinc finger protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04155","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRMT5 and KDM1A share common interaction partners. One such partner is involved in a process where, in murine primordial germ cells, its interaction with a t... | |
medium_convergence_04156 | DCAF7 and CBX3 both interact with a shared protein. Evidence regarding one such shared partner states: 'We identified three ubiquitylated lysine residues and showed that DNA ligase I interacts with and is targeted for ubiquitylation by this entity, a specificity factor for the Cul4-DDB1 complex.' Which cell type is thi... | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_04156","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCAF7 and CBX3 both interact with a shared protein. Evidence regarding one such shared partner states: 'We identified three ubiquitylated lysine residues and... | |
medium_convergence_04158 | Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Evidence for this shared target in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.27 and an adjusted p-value of approximately 0.049... | Neurobeachin-like protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04158","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Evidence for t... | |
medium_convergence_04159 | YAP1 and RBCK1 share multiple protein interaction partners. One such shared partner is characterized by evidence stating: 'The ligand-binding domain (LBD) of a nuclear receptor and the WW domain of YAP were critical for the interaction.' Which protein is encoded by the gene corresponding to this shared interaction part... | Nuclear receptor subfamily 1 group I member 2 | Medium | convergence | {"qa_id":"medium_convergence_04159","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and RBCK1 share multiple protein interaction partners. One such shared partner is characterized by evidence stating: 'The ligand-binding domain (LBD) of... | |
medium_convergence_04160 | FANCB and FAAP100 both interact with a specific protein that serves as a shared binding partner. Evidence indicates that this protein is essential for the stability of the core complex and directly interacts with both FANCB and FAAP100 to form a stable subcomplex. Which protein is encoded by the gene corresponding to t... | E3 ubiquitin-protein ligase FANCL | Medium | convergence | {"qa_id":"medium_convergence_04160","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCB and FAAP100 both interact with a specific protein that serves as a shared binding partner. Evidence indicates that this protein is essential for the st... | |
medium_convergence_04161 | EGFR and EPHA2 share a common interaction partner. Evidence indicates that in Grade IV tumors, this shared partner (integrin-β1) exhibits higher expression and greater heteroassociation with ErbB1 compared to Grade II tumors. Which disease is associated with this shared interaction partner? | hyperthyroidism | Medium | convergence | {"qa_id":"medium_convergence_04161","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and EPHA2 share a common interaction partner. Evidence indicates that in Grade IV tumors, this shared partner (integrin-β1) exhibits higher expression a... | |
medium_convergence_04162 | EGFR and MYD88 share a common interacting partner. Evidence indicates that this partner interacts with EGFR and enhances its stability by inhibiting c-CBL-mediated EGFR ubiquitination. Which gene is connected to this shared partner through a 'binds' relationship? | STAT3 | Medium | convergence | {"qa_id":"medium_convergence_04162","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and MYD88 share a common interacting partner. Evidence indicates that this partner interacts with EGFR and enhances its stability by inhibiting c-CBL-me... | |
medium_convergence_04163 | Both Measles morbillivirus and Rift Valley fever phlebovirus are known to upregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (from study GSE117668) reports a log2 fold change of approximately 1.06 and an adjusted p-value of 0.02375. Which protein is encoded by this gene? | Interferon-induced helicase C domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04163","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Rift Valley fever phlebovirus are known to upregulate a specific gene. Experimental data for this gene in pleural mesothelioma... | |
medium_convergence_04164 | PARP1 and HIST1H2BG share common interacting partners. One such partner is described as binding PARP1 via a central PAR-binding WWE domain and, using its carboxy-terminal HECT domain, catalyzing the polyubiquitylation of PARP1 to trigger its proteasomal degradation and prevent supra-physiological accumulation. Which ce... | basophil | Medium | convergence | {"qa_id":"medium_convergence_04164","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and HIST1H2BG share common interacting partners. One such partner is described as binding PARP1 via a central PAR-binding WWE domain and, using its car... | |
medium_convergence_04165 | CALCOCO2 and ATG4B both interact with a specific shared protein. Evidence regarding this shared entity states: 'We solved the crystal structures of the [entity]-ATG4B C-terminal LIR complex.' Which protein is encoded by this shared entity? | Gamma-aminobutyric acid receptor-associated protein-like 1 | Medium | convergence | {"qa_id":"medium_convergence_04165","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CALCOCO2 and ATG4B both interact with a specific shared protein. Evidence regarding this shared entity states: 'We solved the crystal structures of the [enti... | |
medium_convergence_04166 | Both Human immunodeficiency virus 1 and Zaire ebolavirus are known to downregulate a specific gene. Experimental data from a study on macrophages (GSE108897) indicates that this gene exhibits a log2 fold change of -1.062 and an adjusted p-value of 0.01604. What is the name of the protein encoded by this gene? | TBC1 domain family member 2A | Medium | convergence | {"qa_id":"medium_convergence_04166","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Zaire ebolavirus are known to downregulate a specific gene. Experimental data from a study on macrophages (GSE108897)... | |
medium_convergence_04167 | TRIM28 and SYNCRIP both interact with a shared gene product. Experimental evidence indicates that the interaction between KAP-1 (TRIM28) and this shared entity was verified by co-immunoprecipitation (Co-IP). Which disease is associated with this entity? | melanoma | Medium | convergence | {"qa_id":"medium_convergence_04167","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and SYNCRIP both interact with a shared gene product. Experimental evidence indicates that the interaction between KAP-1 (TRIM28) and this shared enti... | |
medium_convergence_04168 | CCDC22 and CUL1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we show that DNA damage-activated mitotic arrest and CDK activation lead to the phosphorylation of Vps34, which provides a signal to promote its ubiquitination and proteasomal degradation mediated by th... | F-box/LRR-repeat protein 20 | Medium | convergence | {"qa_id":"medium_convergence_04168","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCDC22 and CUL1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we show that DNA damage-activated mitot... | |
medium_convergence_04169 | GCN1L1 and AKT1 share multiple interacting partners. One such partner is described in evidence stating: 'We demonstrate that in platelets PKB is physically associated with PDK1 and this protein.' Which disease is connected to this protein through a biomarker relationship? | glioblastoma | Medium | convergence | {"qa_id":"medium_convergence_04169","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GCN1L1 and AKT1 share multiple interacting partners. One such partner is described in evidence stating: 'We demonstrate that in platelets PKB is physically a... | |
medium_convergence_04171 | Human alphaherpesvirus 1 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.675 and an adjusted p-value of 0.001107. Which protein is encoded by this gene? | Plexin domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04171","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE11496... | |
medium_convergence_04172 | Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicates that for one of these shared targets, the log2 fold change is approximately 2.56 and the adjusted p-value is approximately 0.0207. Which cellular component is this specif... | extracellular space | Medium | convergence | {"qa_id":"medium_convergence_04172","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicates that fo... | |
medium_convergence_04173 | RAD18 and TP53 share common interacting partners. One such shared partner is distinguished by evidence stating: 'Surprisingly, this protein, but not RBBP5 or ASH2L, was found to interact with the DNA damage repair protein RAD18.' Which protein product is encoded by this specific shared interacting partner? | Histone-lysine N-methyltransferase SETD1A | Medium | convergence | {"qa_id":"medium_convergence_04173","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD18 and TP53 share common interacting partners. One such shared partner is distinguished by evidence stating: 'Surprisingly, this protein, but not RBBP5 or... | |
medium_convergence_04174 | NCOA1 and NCOR1 both interact with a specific nuclear receptor. Evidence indicates that this receptor (part of the LXR family) interacts with corepressors N-CoR and SMRT, which are released upon agonist binding. Which protein is encoded by this nuclear receptor gene? | Oxysterols receptor LXR-alpha | Medium | convergence | {"qa_id":"medium_convergence_04174","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCOA1 and NCOR1 both interact with a specific nuclear receptor. Evidence indicates that this receptor (part of the LXR family) interacts with corepressors N-... | |
medium_convergence_04175 | CAND1 and CUL1 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We have now applied this approach to an uncharacterized human F-box protein, which serves as the substrate-recognition subunit of a SKP1-CUL1-F-box protein (SCF)-type E3, thereby identifying EID1 (EP300-... | ubiquitin ligase complex | Medium | convergence | {"qa_id":"medium_convergence_04175","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAND1 and CUL1 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We have now applied this approach to an ... | |
medium_convergence_04176 | BMI1 and PCGF2 both interact with a shared protein partner. Biochemical evidence indicates that this partner (or its homolog YAF2) associates with PCGF-RING1A/B combinations to form complexes that exclude canonical PRC1 subunits such as CBX, PHC, and SCM. What is the protein product encoded by this shared partner? | RING1 and YY1-binding protein | Medium | convergence | {"qa_id":"medium_convergence_04176","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMI1 and PCGF2 both interact with a shared protein partner. Biochemical evidence indicates that this partner (or its homolog YAF2) associates with PCGF-RING1... | |
medium_convergence_04177 | LGR4 and LGR5 each interact with multiple shared partners. Evidence concerning one such shared partner reports that RSPOs bound the LRR1-14 domain of this entity with nanomolar affinities that decreased in the following order in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay: this entity > RSPO2... | R-spondin-4 | Medium | convergence | {"qa_id":"medium_convergence_04177","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LGR4 and LGR5 each interact with multiple shared partners. Evidence concerning one such shared partner reports that RSPOs bound the LRR1-14 domain of this en... | |
medium_convergence_04178 | MYC and PML each interact with more than one shared gene product. Evidence concerning one such shared entity states: 'Using co-immunoprecipitation and mass spectroscopy, we showed that this entity binds to promyelocytic leukemia (PML), a tumor suppressor involved in non-canonical β-catenin signaling.' Which protein is ... | PCI domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04178","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and PML each interact with more than one shared gene product. Evidence concerning one such shared entity states: 'Using co-immunoprecipitation and mass s... | |
medium_convergence_04179 | RNF31 and RIPK1 both interact with a shared protein. Evidence indicates that this shared protein interacts via its PUB domain with CYLD, and a PUB interaction motif (PIM) within this protein binds to the PUB domain of the LUBAC component HOIP. Which disease is associated with this protein as a biomarker? | thymic carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04179","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RNF31 and RIPK1 both interact with a shared protein. Evidence indicates that this shared protein interacts via its PUB domain with CYLD, and a PUB interactio... | |
medium_convergence_04180 | LRRK2 and SFN share multiple interacting partners. One such shared partner is reported to interact with LRRK2 specifically in eukaryotic cells. Which protein is encoded by this shared partner? | Serine/threonine-protein kinase MARK1 | Medium | convergence | {"qa_id":"medium_convergence_04180","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LRRK2 and SFN share multiple interacting partners. One such shared partner is reported to interact with LRRK2 specifically in eukaryotic cells. Which protein... | |
medium_convergence_04181 | CYLD and RIPK1 both interact with a shared protein. Evidence regarding this shared protein states: 'The linear ubiquitin chain assembly complex (LUBAC) regulates immune signaling, and its function is regulated by the deubiquitinases OTULIN and CYLD, which associate with the catalytic subunit of LUBAC.' Which protein is... | E3 ubiquitin-protein ligase RNF31 | Medium | convergence | {"qa_id":"medium_convergence_04181","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CYLD and RIPK1 both interact with a shared protein. Evidence regarding this shared protein states: 'The linear ubiquitin chain assembly complex (LUBAC) regul... | |
medium_convergence_04182 | PLK1 and YWHAG share multiple interacting partners. One such shared partner is characterized by evidence stating that it responds to the HER2 signaling cascade by translocating into the nucleus following Ser273 phosphorylation, and subsequently contributes to cell mitosis regulation by binding with PLK1 to promote the ... | SHC SH2 domain-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04182","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PLK1 and YWHAG share multiple interacting partners. One such shared partner is characterized by evidence stating that it responds to the HER2 signaling casca... | |
medium_convergence_04183 | FANCA and FANCC each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In normal cells, HA-tagged [protein] coimmunoprecipitates with FANCA, FANCC, and FANCG but not with FANCD2.' Which protein is encoded by the gene corresponding to this shared partner? | Fanconi anemia group E protein | Medium | convergence | {"qa_id":"medium_convergence_04183","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCA and FANCC each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In normal cells, HA-tagged [pro... | |
medium_convergence_04185 | Vaccinia virus and Cardiovirus A both upregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 1.126 and an adjusted p-value of approximately 0.000338. Which cell type is this gene enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_04185","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a lo... |
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