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medium_convergence_04417 | ERC2 and GIT1 share a common interaction partner. Evidence indicates that this partner, identified as an active zone-specific isoform (CAST), interacts with all known isoforms of liprin-alpha. Furthermore, liprin-alpha1 associates with both this partner and ERC1b, a splice variant of ERC1 found in cytosolic and active ... | PPFIA3-related neurodevelopmental disorder | Medium | convergence | {"qa_id":"medium_convergence_04417","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERC2 and GIT1 share a common interaction partner. Evidence indicates that this partner, identified as an active zone-specific isoform (CAST), interacts with ... | |
medium_convergence_04419 | COPS5 and EP300 both interact with a specific shared protein. Evidence indicates that CSN5 directly binds this shared protein and decreases its ubiquitination, thereby enhancing its protein stability in renal cell carcinoma (RCC) cells. Which gene encodes this shared protein? | Zinc finger E-box-binding homeobox 1 | Medium | convergence | {"qa_id":"medium_convergence_04419","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and EP300 both interact with a specific shared protein. Evidence indicates that CSN5 directly binds this shared protein and decreases its ubiquitinatio... | |
medium_convergence_04420 | Esmolol and Propranolol both interact with a specific agent. Evidence indicates that pretreatment with Propranolol significantly shifted the dose-response curve of this agent to the left. Specifically, the agent (0.3 mg/ml) increased pulmonary resistance by 7.9 +/- 0.97 cmH2O.l-1.s-1 (mean +/- SEM of seven dogs) after ... | Amifampridine | Medium | convergence | {"qa_id":"medium_convergence_04420","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Esmolol and Propranolol both interact with a specific agent. Evidence indicates that pretreatment with Propranolol significantly shifted the dose-response cu... | |
medium_convergence_04421 | LCK and CBL both interact with a specific shared protein. Evidence indicates that this shared protein interacts with CBL in vivo in a phosphorylation-independent manner. Which protein is encoded by the gene corresponding to this shared entity? | Src-like-adapter 2 | Medium | convergence | {"qa_id":"medium_convergence_04421","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LCK and CBL both interact with a specific shared protein. Evidence indicates that this shared protein interacts with CBL in vivo in a phosphorylation-indepen... | |
medium_convergence_04422 | PNKP and POLM both interact with a specific DNA repair protein. Evidence indicates that polynucleotide kinase (PNK) functions in non-homologous end joining (NHEJ) by processing ionizing radiation-induced DNA termini and interacting via an FHA domain with a CK2-phosphorylated form of this protein. Which gene encodes thi... | DNA repair protein XRCC4 | Medium | convergence | {"qa_id":"medium_convergence_04422","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PNKP and POLM both interact with a specific DNA repair protein. Evidence indicates that polynucleotide kinase (PNK) functions in non-homologous end joining (... | |
medium_convergence_04423 | COPB1 and CAPZA3 both interact with a shared protein partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatomer consisting of beta- and delta-COPs that is able to bind to Golgi membranes in an ARF1- and GTP-dependent manner.' Which protein is encoded by the gene correspon... | Coatomer subunit beta' | Medium | convergence | {"qa_id":"medium_convergence_04423","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPB1 and CAPZA3 both interact with a shared protein partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatom... | |
medium_convergence_04424 | CDC7 and CDC45 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'A novel human protein, [REDACTED] (activator of S phase kinase), was identified on the basis of its ability to bind to human Cdc7-related kinase (huCdc7).' Which protein is encoded by that shared enti... | Protein DBF4 homolog A | Medium | convergence | {"qa_id":"medium_convergence_04424","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC7 and CDC45 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'A novel human protein, [REDACTED] (ac... | |
medium_convergence_04425 | TAB1 and TICAM1 both interact with a specific Toll-like receptor. Evidence indicates that endotoxin tolerization suppresses LPS-inducible associations between this receptor and TRIF, as well as TRIF and TBK1, thereby inhibiting TBK1 kinase activity, IRF-3 activation, and the expression of RANTES and IFN-beta. Which pro... | Toll-like receptor 4 | Medium | convergence | {"qa_id":"medium_convergence_04425","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TAB1 and TICAM1 both interact with a specific Toll-like receptor. Evidence indicates that endotoxin tolerization suppresses LPS-inducible associations betwee... | |
medium_convergence_04427 | PDIA3 and HLA-H both interact with a shared protein partner. Evidence indicates that only wild-type hTpn efficiently recruits heavy chain (HC) and calreticulin (Crt) into complexes with TAP and endoplasmic reticulum p57 (ERp57). Which disease is associated with this shared partner via genomic alterations? | gastroschisis | Medium | convergence | {"qa_id":"medium_convergence_04427","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PDIA3 and HLA-H both interact with a shared protein partner. Evidence indicates that only wild-type hTpn efficiently recruits heavy chain (HC) and calreticul... | |
medium_convergence_04428 | Vaccinia virus and Influenza A virus both downregulate a specific host gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE11238) indicates that this gene exhibits a log2 fold change of -3.991 and an adjusted p-value of 0.01042. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_04428","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Influenza A virus both downregulate a specific host gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE11238) ... | |
medium_convergence_04429 | TRIM28 and CBX3 both interact with a specific shared protein. Evidence indicates that this shared protein associates with transcriptional repressors including KAP1, histone deacetylases HDAC1/2, and the histone methyltransferase G9a/GLP, and it modulates the interaction of HDAC1 and KAP1 with heterochromatin. Which pro... | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 | Medium | convergence | {"qa_id":"medium_convergence_04429","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and CBX3 both interact with a specific shared protein. Evidence indicates that this shared protein associates with transcriptional repressors includin... | |
medium_convergence_04430 | Vaccinia virus and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.528 and an adjusted p-value of 0.009691. Which disease is associated with this gene as a biomarker? | multiple sclerosis | Medium | convergence | {"qa_id":"medium_convergence_04430","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238... | |
medium_convergence_04431 | CHAF1A and EP300 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We now show that this regulation might be more complex; MutSα and CAF-1 interact not only with PCNA, but also with each other.' Which protein is encoded by the gene corresponding to this shared entity? | DNA mismatch repair protein Msh6 | Medium | convergence | {"qa_id":"medium_convergence_04431","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHAF1A and EP300 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We now show that this regulation might be more ... | |
medium_convergence_04432 | NFKB1 and RELA each interact with more than one shared gene. Evidence concerning one shared entity reports: 'Through in vitro binding experiments, a protein was found to bind to several SWI/SNF complex subunits and also to the p52 NF-kappaB subunit through its nuclear localization signal containing the N-terminal regio... | Coffin-Siris syndrome | Medium | convergence | {"qa_id":"medium_convergence_04432","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NFKB1 and RELA each interact with more than one shared gene. Evidence concerning one shared entity reports: 'Through in vitro binding experiments, a protein ... | |
medium_convergence_04433 | CHD4 and HDAC2 both interact with a shared protein. Evidence for one such entity states: 'Here we show that this protein (refs 4, 5, 6, 7, 8) interacts, both in vitro and in vivo, with histone deacetylase (HDAC) proteins.' Which protein is encoded by this entity? | Polycomb protein EED | Medium | convergence | {"qa_id":"medium_convergence_04433","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and HDAC2 both interact with a shared protein. Evidence for one such entity states: 'Here we show that this protein (refs 4, 5, 6, 7, 8) interacts, both... | |
medium_convergence_04434 | Both Influenza A virus and Cardiovirus A are reported to upregulate a specific gene. Experimental data for this gene in non-small cell lung adenocarcinoma cells (study GSE147507) show a log2 fold change of approximately 1.375 and an adjusted p-value of 0.006773. Which cellular component is this gene located in? | extracellular region | Medium | convergence | {"qa_id":"medium_convergence_04434","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Cardiovirus A are reported to upregulate a specific gene. Experimental data for this gene in non-small cell lung adenocarcinoma ce... | |
medium_convergence_04435 | Leuprolide and Phentermine both interact with a specific drug. Clinical evidence regarding this shared interacting drug states that it should be discontinued one week prior to surgery and notes potential interactions with antidepressants. Which disease is this drug indicated for? | premature ejaculation | Medium | convergence | {"qa_id":"medium_convergence_04435","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Leuprolide and Phentermine both interact with a specific drug. Clinical evidence regarding this shared interacting drug states that it should be discontinued... | |
medium_convergence_04436 | Human polyomavirus 1 and Primate bocaparvovirus 1 both upregulate a specific gene. Evidence for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 4.16 and an adjusted p-value of 0.003227. Which disease is associated with this gene through genomic alterations? | syphilis | Medium | convergence | {"qa_id":"medium_convergence_04436","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Primate bocaparvovirus 1 both upregulate a specific gene. Evidence for this gene in renal epithelial cells (study GSE135833) reports... | |
medium_convergence_04437 | KRAS and STX1A share multiple interacting partners. One such shared partner is the subject of the following evidence: 'Here we demonstrate that granuphilin directly binds to syntaxin 1a on the plasma membrane, and this interaction is regulated by Rab27a.' Which protein is encoded by the gene corresponding to this share... | Synaptotagmin-like protein 4 | Medium | convergence | {"qa_id":"medium_convergence_04437","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRAS and STX1A share multiple interacting partners. One such shared partner is the subject of the following evidence: 'Here we demonstrate that granuphilin d... | |
medium_convergence_04438 | ERCC1 and FANCD2 each interact with a shared protein. Evidence concerning one such shared entity reports that in humans, this entity forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with the MSH2/MSH3 mismatch repair complex, the telomere binding complex TE... | Structure-specific endonuclease subunit SLX4 | Medium | convergence | {"qa_id":"medium_convergence_04438","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC1 and FANCD2 each interact with a shared protein. Evidence concerning one such shared entity reports that in humans, this entity forms a multiprotein com... | |
medium_convergence_04439 | Intestinal epithelium and oral epithelium share a common anatomical classification. Evidence regarding one such shared entity describes it as an epithelium that is part of the mouth, lines the oral cavity, is typically stratified squamous, may be para-, ortho-, or non-keratinized, and serves as the primary barrier betw... | mucosa | Medium | convergence | {"qa_id":"medium_convergence_04439","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Intestinal epithelium and oral epithelium share a common anatomical classification. Evidence regarding one such shared entity describes it as an epithelium t... | |
medium_convergence_04441 | Dengue virus and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of 1.109 and an adjusted p-value of 0.03026. Which disease is associated with this gene as a biomarker? | non-small cell lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04441","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports ... | |
medium_convergence_04442 | PDGFB and XBP1 are both involved in more than one shared biological process. Evidence indicates that one of these shared processes is linked to an entity that increases smooth muscle cell (SMC) migration via PI3K/Akt activation and promotes proliferation via downregulation of calponin h1 (CNN1). Which biological proces... | vascular associated smooth muscle cell proliferation | Medium | convergence | {"qa_id":"medium_convergence_04442","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PDGFB and XBP1 are both involved in more than one shared biological process. Evidence indicates that one of these shared processes is linked to an entity tha... | |
medium_convergence_04443 | GATA2 and LMO2 both interact with a specific transcription factor. Evidence indicates that RBTN1 and RBTN2 interact with leukemogenic bHLH proteins, specifically identifying TAL2 and LYL1 among them. Which protein, connected to this identified entity via an 'encodes' relationship, is the shared interaction partner of G... | T-cell acute lymphocytic leukemia protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04443","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GATA2 and LMO2 both interact with a specific transcription factor. Evidence indicates that RBTN1 and RBTN2 interact with leukemogenic bHLH proteins, specific... | |
medium_convergence_04444 | Hepacivirus C and Dengue virus both downregulate a specific gene. Evidence for this gene shows a log2 fold change of approximately -1.67 and an adjusted p-value of approximately 0.017. Which biological process is this gene involved in? | glycophagy | Medium | convergence | {"qa_id":"medium_convergence_04444","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Dengue virus both downregulate a specific gene. Evidence for this gene shows a log2 fold change of approximately -1.67 and an adjusted p-va... | |
medium_convergence_04445 | RAD51 and BRCA1 both interact with a specific shared protein partner. Evidence regarding this partner states: 'Using the yeast two-hybrid system, we isolated a cDNA encoding a novel human protein, named [Protein X], that strongly interacts with human Rad51 recombinase.' Which protein is encoded by this shared partner? | RAD51-associated protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04445","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD51 and BRCA1 both interact with a specific shared protein partner. Evidence regarding this partner states: 'Using the yeast two-hybrid system, we isolated... | |
medium_convergence_04446 | Both Vaccinia virus and Cardiovirus A are known to upregulate a specific host gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE11238) indicates that for one such shared target, the log2 fold change is approximately 1.48 and the adjusted p-value is approximately 2.27e-05. What molecular fun... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_04446","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Cardiovirus A are known to upregulate a specific host gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE... | |
medium_convergence_04448 | CYLD and BIRC3 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We find that this protein interacts via its PUB domain with CYLD, while a PUB interaction motif (PIM) of this protein interacts with the PUB domain of the LUBAC component HOIP.' Which cellular co... | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_04448","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CYLD and BIRC3 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We find that this protein intera... | |
medium_convergence_04449 | Hydrocortisone and Pomalidomide both interact with a specific shared drug. Evidence regarding this shared drug notes that systemic steroids are commonly used to manage immune-related adverse events (irAEs), but it remains unclear whether they may undermine immune checkpoint inhibitor (ICI) therapy outcomes. Which disea... | colorectal cancer | Medium | convergence | {"qa_id":"medium_convergence_04449","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hydrocortisone and Pomalidomide both interact with a specific shared drug. Evidence regarding this shared drug notes that systemic steroids are commonly used... | |
medium_convergence_04451 | Betamethasone and Hydrocortisone both interact with a specific drug. Evidence regarding this drug notes that while systemic steroids are commonly used to manage immune-related adverse events (irAEs), it remains unclear whether they may undermine immune checkpoint inhibitor (ICI) therapy outcomes. Which disease is this ... | colorectal cancer | Medium | convergence | {"qa_id":"medium_convergence_04451","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Betamethasone and Hydrocortisone both interact with a specific drug. Evidence regarding this drug notes that while systemic steroids are commonly used to man... | |
medium_convergence_04452 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of approximately -4.24 and an adjusted p-value of approximately 0.025. Which disease is associated with this gene? | fibrosarcoma | Medium | convergence | {"qa_id":"medium_convergence_04452","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study G... | |
medium_convergence_04453 | CDK2 and ARFGEF2 share common interacting partners. One such shared partner is implicated in evidence stating: 'Coimmunoprecipitation experiments confirmed interaction of in vitro translated BIG2 and RI alpha, as well as of the endogenous proteins in cytosol of cultured HepG2 cells.' Which protein is encoded by this sh... | cAMP-dependent protein kinase type I-alpha regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_04453","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and ARFGEF2 share common interacting partners. One such shared partner is implicated in evidence stating: 'Coimmunoprecipitation experiments confirmed i... | |
medium_convergence_04454 | CSNK1D and FBXW11 both interact with a shared protein target. Evidence regarding one such target states: 'We have now extended our previous studies to show that human casein kinase Idelta (hCKIdelta), the closest homologue to hCKIepsilon, associates with and phosphorylates hPER1 and causes protein instability.' Which p... | Period circadian protein homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_04454","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK1D and FBXW11 both interact with a shared protein target. Evidence regarding one such target states: 'We have now extended our previous studies to show t... | |
medium_convergence_04456 | LRP8 and ARHGEF2 both interact with a specific protein that serves as a molecular scaffold for the JNK-signaling pathway. Evidence indicates that ApoER2, but not VLDLR, binds to this family of JNK-interacting proteins (JIPs). Which protein product is encoded by this shared interacting partner? | C-Jun-amino-terminal kinase-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04456","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LRP8 and ARHGEF2 both interact with a specific protein that serves as a molecular scaffold for the JNK-signaling pathway. Evidence indicates that ApoER2, but... | |
medium_convergence_04457 | STAMBP and GABARAP both interact with a specific shared protein. Experimental evidence indicates that the N-terminal proline/serine-rich (PS) domain of this shared protein (amino acids 287-416) is required for its interaction with GATE-16 and GABARAP, as demonstrated by yeast two-hybrid and in vitro GST pull-down assay... | Serine/threonine-protein kinase ULK1 | Medium | convergence | {"qa_id":"medium_convergence_04457","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STAMBP and GABARAP both interact with a specific shared protein. Experimental evidence indicates that the N-terminal proline/serine-rich (PS) domain of this ... | |
medium_convergence_04458 | CHEK2 and DCLRE1C share multiple binding partners. One such shared partner interacts with CHEK2 via its FHA domain and the phosphorylated Thr 68 residue of CHEK2. Which disease is associated with this specific shared partner as a biomarker? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04458","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK2 and DCLRE1C share multiple binding partners. One such shared partner interacts with CHEK2 via its FHA domain and the phosphorylated Thr 68 residue of C... | |
medium_convergence_04459 | RPS27A and BRCA1 share multiple binding partners. One of these shared partners is implicated in a study stating: 'By using NMR spectroscopy and site-directed mutagenesis, we have mapped the binding site on the BRCA1-BARD1 heterodimer for the Ub-conjugating enzyme UbcH5c.' Which disease is associated with this specific ... | systemic lupus erythematosus | Medium | convergence | {"qa_id":"medium_convergence_04459","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPS27A and BRCA1 share multiple binding partners. One of these shared partners is implicated in a study stating: 'By using NMR spectroscopy and site-directed... | |
medium_convergence_04460 | FBXW7 and VDR both interact with a shared protein. Evidence indicates that Fbw7, a tumor suppressor and ubiquitin ligase, binds to the CDK8-Mediator complex and targets this shared protein (referred to as 13L) for degradation. Which protein is encoded by the gene corresponding to this shared entity? | Mediator of RNA polymerase II transcription subunit 13 | Medium | convergence | {"qa_id":"medium_convergence_04460","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW7 and VDR both interact with a shared protein. Evidence indicates that Fbw7, a tumor suppressor and ubiquitin ligase, binds to the CDK8-Mediator complex ... | |
medium_convergence_04461 | Triprolidine and Cyproheptadine both interact with a specific shared drug. Evidence indicates that while p-Chlorophenylalanine and methergoline had no effect, this shared drug enhanced the anticonvulsive action of most benzodiazepines tested. Which disease is this shared drug indicated for? | anxiety | Medium | convergence | {"qa_id":"medium_convergence_04461","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Triprolidine and Cyproheptadine both interact with a specific shared drug. Evidence indicates that while p-Chlorophenylalanine and methergoline had no effect... | |
medium_convergence_04462 | CLSPN and CDC6 share multiple binding partners. One shared partner is a DNA helicase subunit whose interaction with Claspin is lost upon Cdc7 inhibition. Which disease is associated with this specific helicase subunit? | autosomal dominant nonsyndromic hearing loss 70 | Medium | convergence | {"qa_id":"medium_convergence_04462","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLSPN and CDC6 share multiple binding partners. One shared partner is a DNA helicase subunit whose interaction with Claspin is lost upon Cdc7 inhibition. Whi... | |
medium_convergence_04464 | PARD6A and CDC42 share multiple binding partners. One such shared partner is implicated in a complex where ECT2 interacts with Par6, Par3, and PKCzeta. Which protein is encoded by this shared partner? | Protein kinase C zeta type | Medium | convergence | {"qa_id":"medium_convergence_04464","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARD6A and CDC42 share multiple binding partners. One such shared partner is implicated in a complex where ECT2 interacts with Par6, Par3, and PKCzeta. Which... | |
medium_convergence_04465 | CDC37 and EMD both interact with a specific protein. Evidence indicates that this protein is part of a cohort of chaperones and co-chaperones, including Hsp90 and CDC37, that bind to a specific kinase but not its homolog in 293T cells. Which protein is encoded by the gene corresponding to this interacting entity? | Interleukin-1 receptor-associated kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_04465","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and EMD both interact with a specific protein. Evidence indicates that this protein is part of a cohort of chaperones and co-chaperones, including Hsp9... | |
medium_convergence_04466 | NUDT21 and SIN3A both interact with a shared protein. Evidence indicates that this shared protein interacts with the corepressor complex mSin3A/histone deacetylase (HDAC) at the hTERT promoter. Which protein is encoded by the gene corresponding to this shared entity? | Transcriptional repressor NF-X1 | Medium | convergence | {"qa_id":"medium_convergence_04466","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUDT21 and SIN3A both interact with a shared protein. Evidence indicates that this shared protein interacts with the corepressor complex mSin3A/histone deace... | |
medium_convergence_04468 | CTBP1 and CTBP2 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'Screening for proteins that interact with subdomains 1 and 2 of Foxp2 using yeast two-hybrid analysis revealed that subdomain 2 binds to C-terminal binding protein 1, which can synergistically repress transcrip... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_04468","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and CTBP2 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'Screening for proteins that interact with subdo... | |
medium_convergence_04469 | EPRS1 and LARS1 both interact with a shared protein partner. Evidence regarding this partner states: 'The EPRS repeats also showed the binding activity to the N-terminal motif of arginyl-tRNA synthetase as well as to various nucleic acids, including tRNA.' Which protein is encoded by the gene corresponding to this shar... | Arginine--tRNA ligase, cytoplasmic | Medium | convergence | {"qa_id":"medium_convergence_04469","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPRS1 and LARS1 both interact with a shared protein partner. Evidence regarding this partner states: 'The EPRS repeats also showed the binding activity to th... | |
medium_convergence_04470 | BMP6 and GDF5 both interact with a specific receptor protein. Evidence indicates that BMP-6 weakly binds to BMPR-IA (also known as ALK-3), a receptor to which BMP-2 also binds. Which protein is encoded by the gene corresponding to this receptor? | Bone morphogenetic protein receptor type-1A | Medium | convergence | {"qa_id":"medium_convergence_04470","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP6 and GDF5 both interact with a specific receptor protein. Evidence indicates that BMP-6 weakly binds to BMPR-IA (also known as ALK-3), a receptor to whic... | |
medium_convergence_04472 | Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Evidence for this shared target in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of -3.637 and an adjusted p-value of 0.01015. Which protein is encoded by this gene? | Lysine-specific demethylase 7A | Medium | convergence | {"qa_id":"medium_convergence_04472","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Evidence for this shared target in a cervical adenocarcinoma cell line (study GSE... | |
medium_convergence_04473 | BMPR1B and BMPR2 both interact with a common protein partner. Evidence regarding this partner states: 'Using antibody-mediated immunofluorescence copatching of epitope-tagged receptors, we provide evidence in live cells for preexisting heteromeric (BR-II/BR-Ia and BR-II/BR-Ib) and homomeric (BR-II/BR-II, BR-Ia/ BR-Ia, ... | Bone morphogenetic protein receptor type-1A | Medium | convergence | {"qa_id":"medium_convergence_04473","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMPR1B and BMPR2 both interact with a common protein partner. Evidence regarding this partner states: 'Using antibody-mediated immunofluorescence copatching ... | |
medium_convergence_04474 | RBMX and MYC share a common interacting partner. Evidence regarding this shared entity notes that hnRNP-G and RBM non-specifically bind RNA, but directly and specifically bind Htra2-beta1, an SR-like splicing factor which stimulates inclusion of exon 7 through a direct interaction with the AG-rich ESE in SMN2 exon 7 pr... | Ramond-Elliott neurodevelopmental syndrome | Medium | convergence | {"qa_id":"medium_convergence_04474","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RBMX and MYC share a common interacting partner. Evidence regarding this shared entity notes that hnRNP-G and RBM non-specifically bind RNA, but directly and... | |
medium_convergence_04476 | CRYAA and CRYAB both interact with a shared protein. Experimental evidence indicates that motifs III and IV of betaA3-crystallin interact with alphaA-crystallin, while motifs II and III of betaA3-crystallin primarily interact with alphaB-crystallin. Which biological process is this shared protein involved in? | visual perception | Medium | convergence | {"qa_id":"medium_convergence_04476","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRYAA and CRYAB both interact with a shared protein. Experimental evidence indicates that motifs III and IV of betaA3-crystallin interact with alphaA-crystal... | |
medium_convergence_04477 | NCSTN and PSEN1 both interact with a shared protein complex component. Evidence regarding this shared entity indicates that subcellular fractionation of membrane vesicles and subsequent coimmunoprecipitation of individual gamma-secretase components revealed that interactions among all proteins occurred in the Golgi/tra... | Dowling-Degos disease | Medium | convergence | {"qa_id":"medium_convergence_04477","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCSTN and PSEN1 both interact with a shared protein complex component. Evidence regarding this shared entity indicates that subcellular fractionation of memb... | |
medium_convergence_04478 | CENPA and CENPQ each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosomal CENP-A complexes to identify direct CENP-A partners involved in such a mechanism and identified this protein.' Which disease is associated with that specific ent... | astrocytoma (excluding glioblastoma) | Medium | convergence | {"qa_id":"medium_convergence_04478","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and CENPQ each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosoma... | |
medium_convergence_04479 | H2AX and PRKDC both interact with a shared protein. Evidence indicates that this shared protein co-localizes and associates with gamma-H2AX, a marker of DNA double-strand breaks, following cellular exposure to gamma-irradiation. Which protein is encoded by the gene corresponding to this shared entity? | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | Medium | convergence | {"qa_id":"medium_convergence_04479","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H2AX and PRKDC both interact with a shared protein. Evidence indicates that this shared protein co-localizes and associates with gamma-H2AX, a marker of DNA ... | |
medium_convergence_04480 | EP300 and JUN both interact with a shared protein entity. Evidence regarding this entity states: 'We show that transcription factors of the nuclear factor of activated T cells (NFAT) family bind p300/CBP and recruit histone acetyltransferase activity from T cell nuclear extracts.' Which protein is encoded by this share... | Nuclear factor of activated T-cells, cytoplasmic 2 | Medium | convergence | {"qa_id":"medium_convergence_04480","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and JUN both interact with a shared protein entity. Evidence regarding this entity states: 'We show that transcription factors of the nuclear factor of... | |
medium_convergence_04481 | CENPO and CENPT each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The CENP-T·CENP-W complex is a recently identified inner centromere component that plays crucial roles in the formation of a functional kinetochore involved in cell division during mitosis.' Whi... | Centromere protein W | Medium | convergence | {"qa_id":"medium_convergence_04481","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPO and CENPT each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The CENP-T·CENP-W complex is a ... | |
medium_convergence_04482 | EGFR and FGFR1 share common interaction partners. One such shared partner has been experimentally shown to interact with both Cbl and EGFR. Which gene is connected to this shared partner through a 'binds' relationship? | LRFN3 | Medium | convergence | {"qa_id":"medium_convergence_04482","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and FGFR1 share common interaction partners. One such shared partner has been experimentally shown to interact with both Cbl and EGFR. Which gene is con... | |
medium_convergence_04483 | LEF1 and HDAC3 both interact with a shared transcriptional corepressor. Evidence indicates that this corepressor (referred to as TLE/Gro) interacts with LEF-1 and Pan, and inhibits LEF-1:beta-catenin-dependent transcription. Which cell type is this corepressor enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_04483","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LEF1 and HDAC3 both interact with a shared transcriptional corepressor. Evidence indicates that this corepressor (referred to as TLE/Gro) interacts with LEF-... | |
medium_convergence_04484 | CREBBP and LEF1 share multiple binding partners. One such partner is supported by evidence stating that transfected and endogenous human Pygopus2 and CBP proteins co-immunoprecipitate in HEK-293 cells and co-localize in SW480 colorectal cancer cells. Which disease is associated with this specific entity via a biomarker... | glioma | Medium | convergence | {"qa_id":"medium_convergence_04484","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and LEF1 share multiple binding partners. One such partner is supported by evidence stating that transfected and endogenous human Pygopus2 and CBP pro... | |
medium_convergence_04485 | Primate erythroparvovirus 1 and Severe acute respiratory syndrome-related coronavirus both upregulate a specific gene in erythroid progenitor cells. Experimental data from study GSE103460 indicates that for this shared target, the log2 fold change is approximately 1.133 and the adjusted p-value is 0.03807. Which protei... | Autotaxin | Medium | convergence | {"qa_id":"medium_convergence_04485","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Primate erythroparvovirus 1 and Severe acute respiratory syndrome-related coronavirus both upregulate a specific gene in erythroid progenitor cells. Experime... | |
medium_convergence_04486 | BOP1 and LAS1L each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We also identified the interaction of this entity with LAS1L and SENP3, components of the MLL1-WDR5 supercomplex involving chromatin remodeling.' Which disease is connected to that entity through genomic alte... | familial glucocorticoid deficiency | Medium | convergence | {"qa_id":"medium_convergence_04486","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BOP1 and LAS1L each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We also identified the interaction of this en... | |
medium_convergence_04487 | DLG4 and DLGAP3 both interact with a shared protein partner. Experimental evidence regarding this partner states: 'Using the PDZ domains of ProSAP1 and 2 as bait in the yeast two-hybrid system, we isolated several clones of the SAPAP/GKAP (SAP90/PSD-95-associated protein/guanylate kinase-associated protein) family.' Wh... | SH3 and multiple ankyrin repeat domains protein 3 | Medium | convergence | {"qa_id":"medium_convergence_04487","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG4 and DLGAP3 both interact with a shared protein partner. Experimental evidence regarding this partner states: 'Using the PDZ domains of ProSAP1 and 2 as ... | |
medium_convergence_04488 | HSPA9 and PRKN share multiple interacting partners. One such shared partner is described in the following evidence: 'Here, we demonstrate that Parkin interacts with, ubiquitylates and promotes the degradation of a key structural component of the mammalian aminoacyl-tRNA synthetase complex.' Which protein encodes this s... | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04488","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA9 and PRKN share multiple interacting partners. One such shared partner is described in the following evidence: 'Here, we demonstrate that Parkin interac... | |
medium_convergence_04489 | Both Human alphaherpesvirus 1 and Hepacivirus C are known to downregulate a specific shared host gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately -1.66 and an adjusted p-value of 0.0011. Which cellular component is this gene located in... | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_04489","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Hepacivirus C are known to downregulate a specific shared host gene. Experimental data for this gene in a monocytic leukemi... | |
medium_convergence_04491 | Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE120891) reports a log2 fold change of approximately 1.125 and an adjusted p-value of 0.004406. Which protein is encoded by this gene? | Ras-related protein Rab-30 | Medium | convergence | {"qa_id":"medium_convergence_04491","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GS... | |
medium_convergence_04492 | HSP90AA1 and MAP3K7 both interact with a shared protein. Evidence indicates that functional inhibition of Hsp90 by the anti-tumor agent geldanamycin (GA) efficiently disrupts its interaction with this shared protein, resulting in its degradation and subsequent blockage of p100 processing. Which protein is encoded by th... | Mitogen-activated protein kinase kinase kinase 14 | Medium | convergence | {"qa_id":"medium_convergence_04492","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and MAP3K7 both interact with a shared protein. Evidence indicates that functional inhibition of Hsp90 by the anti-tumor agent geldanamycin (GA) eff... | |
medium_convergence_04493 | Both Human gammaherpesvirus 4 and Enterovirus A are known to downregulate a specific host gene. Experimental data for this gene in gamma delta T-lymphocytes (from study GSE13906) shows a log2 fold change of approximately -1.97 and an adjusted p-value of approximately 0.026. In which cellular component is the protein pr... | focal adhesion | Medium | convergence | {"qa_id":"medium_convergence_04493","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human gammaherpesvirus 4 and Enterovirus A are known to downregulate a specific host gene. Experimental data for this gene in gamma delta T-lymphocytes ... | |
medium_convergence_04494 | STUB1 and HSP90AA1 share multiple interacting partners. One such partner is described in evidence stating: 'We show that CHIP interacts with a mixed lineage kinase and, together with the E2 ubiquitin-conjugating enzyme UbcH5 (UbcH5a, -b, -c, or -d), ubiquitinates this kinase in vitro.' Which disease is associated with ... | cerebral infarction | Medium | convergence | {"qa_id":"medium_convergence_04494","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and HSP90AA1 share multiple interacting partners. One such partner is described in evidence stating: 'We show that CHIP interacts with a mixed lineage ... | |
medium_convergence_04496 | Both the regulation of Purkinje myocyte action potential and the regulation of SA node cell action potential are subtypes of a shared biological process. Evidence regarding this shared process states: 'Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a... | cardiac muscle cell action potential | Medium | convergence | {"qa_id":"medium_convergence_04496","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the regulation of Purkinje myocyte action potential and the regulation of SA node cell action potential are subtypes of a shared biological process. Evi... | |
medium_convergence_04497 | Neutrophil homeostasis and mast cell homeostasis are both subtypes of a shared biological process. Evidence regarding this shared process describes the regulation of neutrophil proliferation and elimination to maintain stable numbers in the absence of external stimuli. Which cell type is the target population of this s... | myeloid cell | Medium | convergence | {"qa_id":"medium_convergence_04497","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Neutrophil homeostasis and mast cell homeostasis are both subtypes of a shared biological process. Evidence regarding this shared process describes the regul... | |
medium_convergence_04498 | Human gammaherpesvirus 4 and Cardiovirus A both downregulate a specific gene. Experimental data for this gene in gamma delta T-lymphocytes (from study GSE13906) reports a log2 fold change of approximately -1.041 and an adjusted p-value of 0.03107. Which protein is encoded by this gene? | Probable E3 ubiquitin-protein ligase HECTD2 | Medium | convergence | {"qa_id":"medium_convergence_04498","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human gammaherpesvirus 4 and Cardiovirus A both downregulate a specific gene. Experimental data for this gene in gamma delta T-lymphocytes (from study GSE139... | |
medium_convergence_04499 | Human respirovirus 3 and Influenza A virus both upregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) reports a log2 fold change of 1.446 and an adjusted p-value of 0.04936. Which disease is associated with this gene through genomic alterations? | breast ductal adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_04499","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Influenza A virus both upregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line... | |
medium_convergence_04500 | HEXIM1 and LARP7 both interact with a specific gene product. Experimental evidence indicates that MAQ1 binds directly to the N-terminal cyclin homology region of cyclins T1 and T2. Which protein is encoded by the gene product shared by HEXIM1 and LARP7 that is implicated in this interaction context? | Cyclin-T2 | Medium | convergence | {"qa_id":"medium_convergence_04500","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HEXIM1 and LARP7 both interact with a specific gene product. Experimental evidence indicates that MAQ1 binds directly to the N-terminal cyclin homology regio... | |
medium_convergence_04501 | Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of 1.088 and an adjusted p-value of 0.04043. Which molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_04501","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a... | |
medium_convergence_04502 | CRY1 and CRY2 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that a specific variant of CRY2 exhibited unexpected resistance to degradation via the canonical proteasomal pathway. This resistance was primarily due to the loss of interactions with E3 li... | Putative F-box/LRR-repeat protein 21 | Medium | convergence | {"qa_id":"medium_convergence_04502","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRY1 and CRY2 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that a specific variant of ... | |
medium_convergence_04503 | ESR1 and NR3C1 share a common interacting partner. Evidence for one such partner states: 'In search of such receptor interacting proteins, we have screened a human cDNA expression library and isolated a human protein that interacts in vitro with transcriptionally active estrogen receptors (ER).' Which disease is associ... | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04503","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and NR3C1 share a common interacting partner. Evidence for one such partner states: 'In search of such receptor interacting proteins, we have screened a... | |
medium_convergence_04504 | SMAD2 and SMAD7 both interact with a specific protein. Evidence indicates that this protein, along with SMAD2 and SMAD3, can form a complex with the activin receptor in a ligand-dependent manner. Which protein is encoded by the gene corresponding to this interacting partner? | Activin receptor type-1B | Medium | convergence | {"qa_id":"medium_convergence_04504","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD2 and SMAD7 both interact with a specific protein. Evidence indicates that this protein, along with SMAD2 and SMAD3, can form a complex with the activin ... | |
medium_convergence_04505 | HDAC6 and EP300 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with the transcriptional coactivator p300, resulting in the acetylation of the shared protein on two lysine residues in its N terminus. Which gene encodes this shared protein? | SMAD family member 7 | Medium | convergence | {"qa_id":"medium_convergence_04505","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and EP300 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with the transcriptional coactivator p300... | |
medium_convergence_04506 | CRY2 and AXIN1 share common binding partners. One such shared partner is implicated in a study stating: 'We also found that both CKIalpha and [this protein] interacted with Axin, whereas CKIIalpha did not bind to Axin and had no effect on Axin-mediated JNK activity even though CKIIalpha has also been suggested to be an... | Casein kinase I isoform epsilon | Medium | convergence | {"qa_id":"medium_convergence_04506","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRY2 and AXIN1 share common binding partners. One such shared partner is implicated in a study stating: 'We also found that both CKIalpha and [this protein] ... | |
medium_convergence_04507 | CRY2 and CAND1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that when un-neddylated cullins are bound by this partner, the interaction prevents the recruitment of substrates. Which protein is encoded by the gene corresponding to that shared entity? | Cullin-1 | Medium | convergence | {"qa_id":"medium_convergence_04507","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRY2 and CAND1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that when un-neddylated cu... | |
medium_convergence_04509 | BMP4 and GDF5 both interact with a specific receptor. Experimental evidence indicates that in transfected COS-1 cells, osteogenic protein (OP)-1/BMP-7, and less efficiently BMP-4, bound to this receptor. Which disease is causally linked to this receptor? | portal hypertension | Medium | convergence | {"qa_id":"medium_convergence_04509","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP4 and GDF5 both interact with a specific receptor. Experimental evidence indicates that in transfected COS-1 cells, osteogenic protein (OP)-1/BMP-7, and l... | |
medium_convergence_04510 | HYOU1 and B3GNT2 both interact with a shared protein. Evidence indicates that Grp170 binds to this shared entity, which serves as an adapter for the transmembrane Hrd1 E3 ubiquitin ligase (postulated to be the retrotranslocon), and links this interaction to Grp170's function during ERAD. Which protein is encoded by thi... | Protein sel-1 homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_04510","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HYOU1 and B3GNT2 both interact with a shared protein. Evidence indicates that Grp170 binds to this shared entity, which serves as an adapter for the transmem... | |
medium_convergence_04511 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of 1.615 and an adjusted p-value of 0.007018. Which protein is encoded by this gene? | Cysteine/serine-rich nuclear protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04511","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (stud... | |
medium_convergence_04512 | FKBP5 and CASP8 both interact with a shared protein. Evidence indicates that Caspase 8 interacts with multiple proteins involved in the activation of the NF-kappaB pathway, specifically including the serine-threonine kinases RIP, NIK, IKK1, and a kinase encoded by the gene IKBKB. Which protein, encoded by the gene corr... | Inhibitor of nuclear factor kappa-B kinase subunit beta | Medium | convergence | {"qa_id":"medium_convergence_04512","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FKBP5 and CASP8 both interact with a shared protein. Evidence indicates that Caspase 8 interacts with multiple proteins involved in the activation of the NF-... | |
medium_convergence_04513 | Rhinovirus A and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) shows a log2 fold change of 1.088 and an adjusted p-value of 0.04043. Which protein is encoded by this gene? | Interleukin-32 | Medium | convergence | {"qa_id":"medium_convergence_04513","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) shows a log... | |
medium_convergence_04516 | Alteplase and Streptokinase share a common interacting drug. Clinical evidence indicates that Hematoma Expansion (HT) and/or Intracerebral Hemorrhage (ICH) signals were detected in patients receiving this shared drug in combination with aspirin, P2Y12 inhibitors, cilostazol, ozagrel sodium, direct oral anticoagulants, ... | heparin-induced thrombocytopenia | Medium | convergence | {"qa_id":"medium_convergence_04516","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Alteplase and Streptokinase share a common interacting drug. Clinical evidence indicates that Hematoma Expansion (HT) and/or Intracerebral Hemorrhage (ICH) s... | |
medium_convergence_04517 | The genes ANK2 and SCN5A are both involved in a specific cardiac action potential process. Evidence indicates that the human cardiac sodium channel Na(v)1.5, encoded by the SCN5A gene, plays a critical role in cardiac excitability and the propagation of action potentials. Which cell type is the site of this specific ac... | regular ventricular cardiac myocyte | Medium | convergence | {"qa_id":"medium_convergence_04517","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The genes ANK2 and SCN5A are both involved in a specific cardiac action potential process. Evidence indicates that the human cardiac sodium channel Na(v)1.5,... | |
medium_convergence_04518 | TRIM28 and CDK7 both interact with a specific shared protein. Evidence indicates that KAP1 binds this protein, which functions as a transcription factor, in a retinoblastoma protein (pRb)-independent manner and inhibits its activity. Which gene encodes this protein? | Transcription factor E2F1 | Medium | convergence | {"qa_id":"medium_convergence_04518","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and CDK7 both interact with a specific shared protein. Evidence indicates that KAP1 binds this protein, which functions as a transcription factor, in ... | |
medium_convergence_04519 | YWHAQ and KRAS share multiple interacting partners. One such shared partner is implicated in evidence stating that 'Four 14-3-3 isoforms (beta, epsilon, eta, tau) were identified interacting with the hPFTAIRE1.' Which disease is associated with this specific shared partner via a biomarker relationship? | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04519","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and KRAS share multiple interacting partners. One such shared partner is implicated in evidence stating that 'Four 14-3-3 isoforms (beta, epsilon, eta,... | |
medium_convergence_04520 | TNNC2 and TNNC1 both interact with a shared protein partner. Evidence regarding this partner states: 'Cardiac troponin I (cTnI) is the inhibitory component of the troponin complex, and its interaction with cardiac troponin C (cTnC) plays a critical role in transmitting the Ca(2+) signal to the other myofilament protein... | Troponin I, slow skeletal muscle | Medium | convergence | {"qa_id":"medium_convergence_04520","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TNNC2 and TNNC1 both interact with a shared protein partner. Evidence regarding this partner states: 'Cardiac troponin I (cTnI) is the inhibitory component o... | |
medium_convergence_04521 | POLR2E and PIH1D1 share a common interacting partner. Experimental evidence indicates that this shared partner interacts with both PIH1D1 and Monad in HEK293 or U2OS cells. Which protein is encoded by this shared interacting partner? | RNA polymerase II-associated protein 3 | Medium | convergence | {"qa_id":"medium_convergence_04521","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLR2E and PIH1D1 share a common interacting partner. Experimental evidence indicates that this shared partner interacts with both PIH1D1 and Monad in HEK293... | |
medium_convergence_04522 | CHD3 and AGO2 both interact with a specific histone H3 variant. Evidence indicates that the tandem PHD fingers of CHD3 bind to the histone H3 tails of this variant, and that posttranslational modifications such as H3K9 methylation or acetylation enhance this interaction. Which protein is encoded by this specific histon... | Histone H3.1 | Medium | convergence | {"qa_id":"medium_convergence_04522","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and AGO2 both interact with a specific histone H3 variant. Evidence indicates that the tandem PHD fingers of CHD3 bind to the histone H3 tails of this v... | |
medium_convergence_04523 | Both ATR and PRKDC interact with a specific shared protein. Evidence indicates that this shared protein interacts with and stabilizes all six members of the PIKK family of proteins (mTOR, ATM, ATR, DNA-PKcs, SMG-1, and TRRAP). Which protein is encoded by the gene corresponding to this shared entity? | TELO2-interacting protein 1 homolog | Medium | convergence | {"qa_id":"medium_convergence_04523","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ATR and PRKDC interact with a specific shared protein. Evidence indicates that this shared protein interacts with and stabilizes all six members of the ... | |
medium_convergence_04524 | EIF3E and EIF3I both interact with a shared protein partner. Evidence regarding this partner states: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which protein is encoded by this shared partner? | Eukaryotic translation initiation factor 3 subunit M | Medium | convergence | {"qa_id":"medium_convergence_04524","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3E and EIF3I both interact with a shared protein partner. Evidence regarding this partner states: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 i... | |
medium_convergence_04525 | EIF3E and EIF3F both interact with a shared protein partner. Evidence regarding one such partner states: 'A direct protein-protein interaction occurs between [the protein encoded by the shared partner] and Int-6, but the analysis of different mutants of [the protein encoded by the shared partner] indicated that a large... | Eukaryotic translation initiation factor 3 subunit L | Medium | convergence | {"qa_id":"medium_convergence_04525","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3E and EIF3F both interact with a shared protein partner. Evidence regarding one such partner states: 'A direct protein-protein interaction occurs between... | |
medium_convergence_04526 | GNA13 and GNA14 both interact with a specific receptor. Experimental evidence indicates that purification of this receptor using the ligand SQ31,491 resulted in the co-purification of a member of the G12 family (specifically Galpha13). Which disease is associated with this receptor as a biomarker? | lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04526","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNA13 and GNA14 both interact with a specific receptor. Experimental evidence indicates that purification of this receptor using the ligand SQ31,491 resulted... | |
medium_convergence_04527 | EHMT2 and DAXX share multiple interaction partners. One such shared partner is reported to directly bind G9a both in vivo and in vitro and to colocalize with it in the nucleus during DNA replication. Which protein is encoded by this shared partner? | DNA (cytosine-5)-methyltransferase 1 | Medium | convergence | {"qa_id":"medium_convergence_04527","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and DAXX share multiple interaction partners. One such shared partner is reported to directly bind G9a both in vivo and in vitro and to colocalize with... | |
medium_convergence_04528 | HSPA8 and HSP90AA1 both interact with a specific shared protein. Evidence regarding this shared protein states: 'Both domains are able to bind to the ATPase domain of HSC70 and inhibit rhodanese aggregation.' Which protein is encoded by the gene corresponding to this shared entity? | Hsc70-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_04528","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA8 and HSP90AA1 both interact with a specific shared protein. Evidence regarding this shared protein states: 'Both domains are able to bind to the ATPase ... | |
medium_convergence_04529 | G3BP1 and MAPT share common interaction partners. One such partner is characterized by evidence stating that cytosolic Tau normally only weakly interacts with it, but mutations mimicking abnormal phosphorylation promote this interaction. Which disease is associated with this specific interaction partner via a biomarker... | polymyositis | Medium | convergence | {"qa_id":"medium_convergence_04529","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"G3BP1 and MAPT share common interaction partners. One such partner is characterized by evidence stating that cytosolic Tau normally only weakly interacts wit... | |
medium_convergence_04530 | Both the androgen receptor (AR) and cyclin D3 (CCND3) interact with a common protein partner. Evidence indicates that the complex formed by this partner and cyclin D3 is unique among D-type cyclin and kinase combinations in its ability to promote the start of the cell cycle. Which protein is encoded by the gene corresp... | Cyclin-dependent kinase 6 | Medium | convergence | {"qa_id":"medium_convergence_04530","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the androgen receptor (AR) and cyclin D3 (CCND3) interact with a common protein partner. Evidence indicates that the complex formed by this partner and ... | |
medium_convergence_04531 | DNAAF4 and DNAH7 are both involved in multiple shared biological processes. One shared process is linked to evidence stating that ultrastructural and immunofluorescence analyses of DYX1C1-mutant motile cilia in mice and humans revealed disruptions of outer and inner dynein arms (ODAs and IDAs, respectively). Which biol... | axonemal dynein complex assembly | Medium | convergence | {"qa_id":"medium_convergence_04531","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNAAF4 and DNAH7 are both involved in multiple shared biological processes. One shared process is linked to evidence stating that ultrastructural and immunof... |
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