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medium_convergence_04642 | CHEK2 and BARD1 both interact with a common protein partner. Evidence indicates that this interaction is mediated by the partner's FHA domain and the phosphorylated Thr 68 residue of CHEK2. Which disease is associated with this specific protein partner? | telangiectasis | Medium | convergence | {"qa_id":"medium_convergence_04642","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK2 and BARD1 both interact with a common protein partner. Evidence indicates that this interaction is mediated by the partner's FHA domain and the phospho... | |
medium_convergence_04644 | PDCD6IP and PTPN23 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'While Alix associated with both ALG-2 and TSG101 in a Ca2+-dependent manner, HD-PTP interacted with ALG-2 Ca2+-dependently but with TSG101 Ca2+-independently.' Which protein is connected to that entity th... | Alpha-1,3/1,6-mannosyltransferase ALG2 | Medium | convergence | {"qa_id":"medium_convergence_04644","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PDCD6IP and PTPN23 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'While Alix associated with both ALG-2 and... | |
medium_convergence_04645 | BIRC2 and LTA share common interaction partners. One such partner is described by evidence stating that a kinase interacts with the second baculovirus IAP repeat (BIR2) domain of c-IAP1 via the IBM, facilitating c-IAP1-mediated ubiquitylation and degradation of this kinase. Which cell type is enriched for this specific... | naive B cell | Medium | convergence | {"qa_id":"medium_convergence_04645","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and LTA share common interaction partners. One such partner is described by evidence stating that a kinase interacts with the second baculovirus IAP re... | |
medium_convergence_04646 | Human alphaherpesvirus 3 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately 1.356 and an adjusted p-value of approximately 8.456e-06. Which protein is encoded by this gene? | C-myc promoter-binding protein | Medium | convergence | {"qa_id":"medium_convergence_04646","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports ... | |
medium_convergence_04647 | Vaccinia virus and Cardiovirus A both upregulate a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene showed a log2 fold change of approximately 1.126 and an adjusted p-value of 0.0003384. What molecular function is enabled by this gene? | protein homodimerization activity | Medium | convergence | {"qa_id":"medium_convergence_04647","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene showed a log2 fo... | |
medium_convergence_04648 | IGF2 and FAM20C each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We now demonstrate using three independent methods that human IGFBP-5, when occupied by IGF-I or IGF-II, forms ternary complexes of approximately 130 kDa with the acid-labile subunit.' Which pro... | Insulin-like growth factor-binding protein 5 | Medium | convergence | {"qa_id":"medium_convergence_04648","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IGF2 and FAM20C each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We now demonstrate using three ... | |
medium_convergence_04649 | WDR5 and HDAC2 share a common interaction partner. Evidence indicates that Atrophin-2 selectively binds histone deacetylase 1/2 (HDAC1/2) through its ELM2/SANT domains. Which disease is associated with this shared interaction partner via a biomarker relationship? | myeloid leukemia | Medium | convergence | {"qa_id":"medium_convergence_04649","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WDR5 and HDAC2 share a common interaction partner. Evidence indicates that Atrophin-2 selectively binds histone deacetylase 1/2 (HDAC1/2) through its ELM2/SA... | |
medium_convergence_04650 | ARL1 and COG6 share a common binding partner. Evidence indicates that the GTP-bound form of this shared partner interacts with the GRIP domains of Golgin-97 and Golgin-245, a process dependent on conserved residues within those GRIP domains that are critical for Golgi targeting. Which protein is encoded by this shared ... | GRIP and coiled-coil domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04650","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARL1 and COG6 share a common binding partner. Evidence indicates that the GTP-bound form of this shared partner interacts with the GRIP domains of Golgin-97 ... | |
medium_convergence_04651 | GAB3 and CSF1R share multiple binding partners. One such partner is described in evidence stating that 'a specific adapter protein interacts with activated Fms on phosphorylated Tyr697, which is also the Grb2-binding site.' Which protein is connected to this shared partner through the 'encodes' relationship? | GRB2-related adapter protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04651","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GAB3 and CSF1R share multiple binding partners. One such partner is described in evidence stating that 'a specific adapter protein interacts with activated F... | |
medium_convergence_04652 | LCP2 and PIK3R1 share a common interacting partner. Experimental evidence indicates that this shared partner co-immunoprecipitates with both SLP-76 and ZAP70 in Jurkat T cells. Which protein is encoded by this shared interacting partner? | SH2 domain-containing adapter protein B | Medium | convergence | {"qa_id":"medium_convergence_04652","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LCP2 and PIK3R1 share a common interacting partner. Experimental evidence indicates that this shared partner co-immunoprecipitates with both SLP-76 and ZAP70... | |
medium_convergence_04653 | ATR and RAD51 both interact with a shared protein. Experimental evidence confirms direct in vitro interactions between this shared protein and both RAD51 and RAD54B. Which protein product is encoded by this shared gene? | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | Medium | convergence | {"qa_id":"medium_convergence_04653","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATR and RAD51 both interact with a shared protein. Experimental evidence confirms direct in vitro interactions between this shared protein and both RAD51 and... | |
medium_convergence_04654 | FOXR2 and ESR1 share multiple interacting partners. One such shared partner is distinguished by experimental evidence showing that, along with AHR, it interacts directly with ER alpha via glutathione S-transferase pull-down assays. Which protein is encoded by this specific shared partner? | Aryl hydrocarbon receptor nuclear translocator | Medium | convergence | {"qa_id":"medium_convergence_04654","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FOXR2 and ESR1 share multiple interacting partners. One such shared partner is distinguished by experimental evidence showing that, along with AHR, it intera... | |
medium_convergence_04655 | DHX37 and BMS1 both interact with a shared protein. Evidence regarding one of these shared partners states: 'In this study, we identified an [entity]-interacting domain in BMS1, which is conserved in zebrafish and humans.' Which disease is associated with this specific shared protein via a biomarker relationship? | fascioliasis | Medium | convergence | {"qa_id":"medium_convergence_04655","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DHX37 and BMS1 both interact with a shared protein. Evidence regarding one of these shared partners states: 'In this study, we identified an [entity]-interac... | |
medium_convergence_04656 | BCAP31 and ESYT1 both interact with a shared protein. Evidence indicates that this shared protein associates physically and functionally with a protein in the DeltaF508 degradation pathway. Which disease is connected to this shared protein through genomic alterations? | acute myeloid leukemia | Medium | convergence | {"qa_id":"medium_convergence_04656","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BCAP31 and ESYT1 both interact with a shared protein. Evidence indicates that this shared protein associates physically and functionally with a protein in th... | |
medium_convergence_04657 | Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific shared gene. Evidence for this gene in a monocytic leukemia cell line reports a log2 fold change of 2.356 and an adjusted p-value of 0.02937. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_04657","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific shared gene. Evidence for this gene in a monocytic leukemia cell line report... | |
medium_convergence_04658 | AMFR and TP53 both interact with a shared protein. Evidence indicates that this shared protein bridges SPFH2 to gp78 in ER membranes, as shown by co-immunoprecipitation studies. Which protein is encoded by this shared entity? | Transmembrane and ubiquitin-like domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04658","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AMFR and TP53 both interact with a shared protein. Evidence indicates that this shared protein bridges SPFH2 to gp78 in ER membranes, as shown by co-immunopr... | |
medium_convergence_04659 | Rift Valley fever phlebovirus and Human mastadenovirus C both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 fold change of 1.745 and an adjusted p-value of 0.04012. Which protein is encoded by this gene? | Aspartate beta-hydroxylase domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04659","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Human mastadenovirus C both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) rep... | |
medium_convergence_04660 | UBR3 and CBX5 share common interaction partners. One such shared partner is implicated in a study stating: 'Our study indicates that RAD6 physically interacts with HP1α and ubiquitinates HP1α at residue K154, thereby promoting HP1α degradation through the autophagy pathway and eventually leading to an open chromatin st... | Ubiquitin-conjugating enzyme E2 B | Medium | convergence | {"qa_id":"medium_convergence_04660","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBR3 and CBX5 share common interaction partners. One such shared partner is implicated in a study stating: 'Our study indicates that RAD6 physically interact... | |
medium_convergence_04661 | CCNH and CCNT1 both interact with a specific protein. Evidence regarding this protein states: 'Here we report the isolation and characterization of three distinct CAK-containing complexes from HeLa nuclear extracts: CAK, a novel CAK-[protein] complex, and TFIIH.' Which disease is associated with this protein as a bioma... | Cockayne syndrome type 2 | Medium | convergence | {"qa_id":"medium_convergence_04661","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCNH and CCNT1 both interact with a specific protein. Evidence regarding this protein states: 'Here we report the isolation and characterization of three dis... | |
medium_convergence_04662 | RAD50 and NBN share multiple interacting partners. One such shared partner is constitutively associated with the MRE11-RAD50-NBS1 (MRN) complex. Which protein is encoded by this shared partner? | ATP-dependent DNA helicase Q5 | Medium | convergence | {"qa_id":"medium_convergence_04662","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD50 and NBN share multiple interacting partners. One such shared partner is constitutively associated with the MRE11-RAD50-NBS1 (MRN) complex. Which protei... | |
medium_convergence_04663 | CREBBP and NFE2L2 share a common interaction partner. Evidence indicates that histone acetyltransferase p300 enhances the transactivation induced by this shared entity and interacts with it both in vitro and in cells transformed by this entity, specifically chicken spleen cells and the B-lymphoma cell line RC-K8, where... | naive B cell | Medium | convergence | {"qa_id":"medium_convergence_04663","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and NFE2L2 share a common interaction partner. Evidence indicates that histone acetyltransferase p300 enhances the transactivation induced by this sha... | |
medium_convergence_04664 | GRB7 and GRAP2 both interact with a common protein target. Experimental evidence indicates that while the adapter protein Grb2 binds to both phosphorylated Tyr-703 and phosphorylated Tyr-936 of this target, the adapter protein Grb7 binds selectively only to phosphorylated Tyr-936. Which protein product is encoded by th... | Mast/stem cell growth factor receptor Kit | Medium | convergence | {"qa_id":"medium_convergence_04664","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB7 and GRAP2 both interact with a common protein target. Experimental evidence indicates that while the adapter protein Grb2 binds to both phosphorylated T... | |
medium_convergence_04666 | Both Influenza A virus and Rhinovirus A are associated with the downregulation of a specific gene. Experimental data for this gene reports a log2 fold change of -1.183 and an adjusted p-value of 0.0005052. Which protein is encoded by this gene? | Histone H2A type 1-B/E | Medium | convergence | {"qa_id":"medium_convergence_04666","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Rhinovirus A are associated with the downregulation of a specific gene. Experimental data for this gene reports a log2 fold change... | |
medium_convergence_04667 | UBLCP1 and MRPS27 both interact with a specific shared protein. Evidence indicates that this shared protein binds to proteasome subunit Rpn1 and dephosphorylates the proteasome. Which protein is encoded by this shared entity? | 26S proteasome non-ATPase regulatory subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_04667","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBLCP1 and MRPS27 both interact with a specific shared protein. Evidence indicates that this shared protein binds to proteasome subunit Rpn1 and dephosphoryl... | |
medium_convergence_04668 | Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE111036) shows a log2 fold change of approximately -1.091 and an adjusted p-value of 0.04521. Which disease is associated with this gene as a biomarker? | secondary neoplasm | Medium | convergence | {"qa_id":"medium_convergence_04668","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE... | |
medium_convergence_04669 | Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) reports a log2 fold change of approximately 1.129 and an adjusted p-value of 0.02809. Which protein is encoded by... | E3 ubiquitin-protein ligase ZNRF2 | Medium | convergence | {"qa_id":"medium_convergence_04669","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data fo... | |
medium_convergence_04671 | ZRANB1 and FBXW7 share multiple interacting partners. One such shared partner is described in a study reporting a novel synthetic lethal genetic interaction between FBXW7 and this entity, identifying it as a new substrate of the SCF-FBXW7 E3 ligase. Which protein is encoded by this shared entity? | Cyclin-L1 | Medium | convergence | {"qa_id":"medium_convergence_04671","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ZRANB1 and FBXW7 share multiple interacting partners. One such shared partner is described in a study reporting a novel synthetic lethal genetic interaction ... | |
medium_convergence_04672 | Both Measles morbillivirus and Dengue virus are known to upregulate a specific shared gene. Experimental data for this gene in pleural mesothelioma cells (from study GSE117668) reports a log2 fold change of approximately 3.646 and an adjusted p-value of 0.0008676. Which cellular component is this gene located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_04672","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Dengue virus are known to upregulate a specific shared gene. Experimental data for this gene in pleural mesothelioma cells (fr... | |
medium_convergence_04673 | ABI2 and CTTN both interact with a shared gene product. Evidence indicates that the localization of this shared gene product in podosomes is attributable to its interaction with the SH3 domain of cortactin. Which disease is associated with this shared gene product? | ovarian neoplasm | Medium | convergence | {"qa_id":"medium_convergence_04673","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ABI2 and CTTN both interact with a shared gene product. Evidence indicates that the localization of this shared gene product in podosomes is attributable to ... | |
medium_convergence_04674 | H2AX and BRCC3 both interact with a specific shared protein. Evidence indicates that this shared protein and SMURF2 function as a stabilizer and destabilizer of H2AX, respectively, through their dynamic interactions with H2AX. Which disease is associated with this shared protein? | telangiectasis | Medium | convergence | {"qa_id":"medium_convergence_04674","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H2AX and BRCC3 both interact with a specific shared protein. Evidence indicates that this shared protein and SMURF2 function as a stabilizer and destabilizer... | |
medium_convergence_04675 | ERCC6 and HDAC2 both interact with a specific protein complex component. Evidence indicates that this component is part of a complex containing HDAC1/2, RbAp46/48, and MBD3, but explicitly excludes Sin3 and Mi2. Which protein, encoded by the gene corresponding to this component, is the target of the 'encodes' relations... | Metastasis-associated protein MTA1 | Medium | convergence | {"qa_id":"medium_convergence_04675","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC6 and HDAC2 both interact with a specific protein complex component. Evidence indicates that this component is part of a complex containing HDAC1/2, RbAp... | |
medium_convergence_04676 | Methylprednisolone and Dexamethasone share a common interacting drug. Evidence regarding one such shared entity notes that a pivotal phase III trial evaluating lenalidomide and dexamethasone in combination with this entity in patients with newly diagnosed multiple myeloma was discontinued due to unexpected safety findi... | colorectal cancer | Medium | convergence | {"qa_id":"medium_convergence_04676","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Methylprednisolone and Dexamethasone share a common interacting drug. Evidence regarding one such shared entity notes that a pivotal phase III trial evaluati... | |
medium_convergence_04677 | SYNCRIP and MDM2 share multiple interaction partners. One such shared partner is described in evidence stating: 'Along with previously identified interactions with the ribosomal proteins, our analysis reveals interactions of HDM2 with the ribosomal translation elongation factor EF1alpha, 40S ribosomal protein [REDACTED... | Small ribosomal subunit protein uS10 | Medium | convergence | {"qa_id":"medium_convergence_04677","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SYNCRIP and MDM2 share multiple interaction partners. One such shared partner is described in evidence stating: 'Along with previously identified interaction... | |
medium_convergence_04678 | WNT5A and WNT3A are both involved in multiple shared biological processes. One of these shared processes is linked to an entity for which evidence indicates that exposure activates a noncanonical signaling pathway and decreases the number of presynaptic terminals. Which biological process is this shared entity a part o... | regulation of synapse structure or activity | Medium | convergence | {"qa_id":"medium_convergence_04678","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WNT5A and WNT3A are both involved in multiple shared biological processes. One of these shared processes is linked to an entity for which evidence indicates ... | |
medium_convergence_04679 | RACK1 (GNB2L1) and MYC share interaction partners. One such shared partner is a deubiquitinating enzyme that forms complexes with FUS (also known as TLS or CHOP). Evidence from co-immunoprecipitation and MS/MS experiments indicates this enzyme's involvement in RNA processing and cell adhesion/morphology. Which cellular... | extracellular exosome | Medium | convergence | {"qa_id":"medium_convergence_04679","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RACK1 (GNB2L1) and MYC share interaction partners. One such shared partner is a deubiquitinating enzyme that forms complexes with FUS (also known as TLS or C... | |
medium_convergence_04681 | CDKN2A and NACA each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We report here that the human homologue of spinophilin/neurabin II, a regulatory subunit of protein phosphatase 1 catalytic subunit specifically interacts with ARF, both in yeast and in mammalian cells.... | Neurabin-2 | Medium | convergence | {"qa_id":"medium_convergence_04681","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN2A and NACA each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We report here that the human homologue... | |
medium_convergence_04682 | GTF2E1 and CCNT2 both interact with a shared protein partner. Evidence regarding this partner indicates that analyses of its binding to other general transcription factors revealed defects in binding to the basic helix-loop-helix motif of TFIIEβ. Which protein is encoded by this shared partner? | Transcription initiation factor IIE subunit beta | Medium | convergence | {"qa_id":"medium_convergence_04682","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2E1 and CCNT2 both interact with a shared protein partner. Evidence regarding this partner indicates that analyses of its binding to other general transcr... | |
medium_convergence_04683 | CETN2 and ERCC2 both interact with a specific protein. Experimental evidence indicates that this protein forms complexes containing CETN2, interacts directly with CETN2, and is stabilized by CETN2 in cooperation with HR23B, a process that enhances the protein's nucleotide excision repair (NER) activity in vitro. Which ... | DNA repair protein complementing XP-C cells | Medium | convergence | {"qa_id":"medium_convergence_04683","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CETN2 and ERCC2 both interact with a specific protein. Experimental evidence indicates that this protein forms complexes containing CETN2, interacts directly... | |
medium_convergence_04685 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of -1.204 and an adjusted p-value of 3.472e-08. Which protein is encoded by this gene? | CD180 antigen | Medium | convergence | {"qa_id":"medium_convergence_04685","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. Experimental data for t... | |
medium_convergence_04686 | FYN and NCK1 both interact with a specific shared protein. Experimental evidence indicates that ligand-activated, tyrosine-autophosphorylated platelet-derived growth factor or epidermal growth factor receptors were coimmunoprecipitated with anti-Nck antibodies, and this association was mediated by the SH2 domain of Nck... | extrahepatic cholestasis | Medium | convergence | {"qa_id":"medium_convergence_04686","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FYN and NCK1 both interact with a specific shared protein. Experimental evidence indicates that ligand-activated, tyrosine-autophosphorylated platelet-derive... | |
medium_convergence_04687 | Amikacin and Oxaliplatin share a common drug interaction partner. Evidence regarding one such partner states: 'Generally, when inhibitors of glycosylation were used with sparfloxacin and amikacin, a synergistic effect was observed for only the smooth variant.' Which disease is this shared interaction partner indicated ... | empyema | Medium | convergence | {"qa_id":"medium_convergence_04687","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Amikacin and Oxaliplatin share a common drug interaction partner. Evidence regarding one such partner states: 'Generally, when inhibitors of glycosylation we... | |
medium_convergence_04688 | ATM and HIST1H4A share a common interacting partner. Evidence regarding this partner states: 'We report here that [the partner] physically associates with ATM, p53, components of the MRE11-RAD50-NBS1 (MRN) complex, and gamma-H2AX.' Which disease is associated with this shared entity via a biomarker relationship? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04688","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and HIST1H4A share a common interacting partner. Evidence regarding this partner states: 'We report here that [the partner] physically associates with AT... | |
medium_convergence_04689 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line (study GSE100576) reports a log2 fold change of approximately 1.709 and an adjusted p-value of 0.008871. Which gene interacts with this upregulated target? | IFIT3 | Medium | convergence | {"qa_id":"medium_convergence_04689","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line (stu... | |
medium_convergence_04690 | YAP1 and NEDD4 share multiple interacting partners. One such shared partner is described by the following evidence: 'Mechanistically, we found that this protein via its LPSY and PPPY motifs recruited the E3 ubiquitin ligase NEDD4, which induced ubiquitination and degradation of Robo1, thus contributing to migration and... | Transmembrane gamma-carboxyglutamic acid protein 4 | Medium | convergence | {"qa_id":"medium_convergence_04690","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and NEDD4 share multiple interacting partners. One such shared partner is described by the following evidence: 'Mechanistically, we found that this prot... | |
medium_convergence_04691 | Both ATR and ATRIP interact with a specific protein. Evidence indicates that this protein interacts with the checkpoint proteins ATR and Rad9. Which disease is associated with this protein? | telangiectasis | Medium | convergence | {"qa_id":"medium_convergence_04691","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ATR and ATRIP interact with a specific protein. Evidence indicates that this protein interacts with the checkpoint proteins ATR and Rad9. Which disease ... | |
medium_convergence_04692 | ATP1A1 and ATP1A4 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'We confirmed that RNF183 interacted with both α1 and β1 subunits; however, we found that RNF183 ubiquitinated only the β1 subunit, not the α1 subunit.' Which protein is encoded by the gen... | Sodium/potassium-transporting ATPase subunit beta-1 | Medium | convergence | {"qa_id":"medium_convergence_04692","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATP1A1 and ATP1A4 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'We confirmed that RNF183... | |
medium_convergence_04693 | TRIM28 and CTNNB1 both interact with a specific shared protein. Evidence indicates that the interaction between KAP-1 (TRIM28) and this shared entity was verified by co-immunoprecipitation (Co-IP). Which protein product is encoded by this shared entity? | Probable ATP-dependent RNA helicase DDX5 | Medium | convergence | {"qa_id":"medium_convergence_04693","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and CTNNB1 both interact with a specific shared protein. Evidence indicates that the interaction between KAP-1 (TRIM28) and this shared entity was ver... | |
medium_convergence_04694 | CENPA and STRA13 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Here, we purified non-nucleosomal CENP-A complexes to identify direct CENP-A partners involved in such a mechanism and identified this protein.' Which disease is associated with that specific p... | astrocytoma (excluding glioblastoma) | Medium | convergence | {"qa_id":"medium_convergence_04694","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and STRA13 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Here, we purified non-nucleoso... | |
medium_convergence_04695 | Both Measles morbillivirus and Zaire ebolavirus are associated with the downregulation of a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) reports a log2 fold change of approximately -1.99 and an adjusted p-value of approximately 4.74e-05. Which protein is encoded by this... | Plexin domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04695","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Zaire ebolavirus are associated with the downregulation of a specific gene. Experimental data for this gene in pleural mesothe... | |
medium_convergence_04696 | ATR and CLSPN both interact with a shared protein. Evidence indicates that TRIM21-mediated K63-linked ubiquitination of CLASPIN counteracts K6-linked ubiquitination of CLASPIN, a modification essential for CLASPIN's interaction with this shared protein and its subsequent chromatin loading. Which gene interacts with thi... | RECQL4 | Medium | convergence | {"qa_id":"medium_convergence_04696","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATR and CLSPN both interact with a shared protein. Evidence indicates that TRIM21-mediated K63-linked ubiquitination of CLASPIN counteracts K6-linked ubiquit... | |
medium_convergence_04697 | TOPBP1 and DDB1 share common interaction partners. One such shared partner is characterized by crystallographic studies of a complex involving cereblon (CRBN), the compound CC-885, and this partner, which reveal that the partner binds to cereblon through a surface turn containing a glycine residue at a key position, in... | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A | Medium | convergence | {"qa_id":"medium_convergence_04697","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and DDB1 share common interaction partners. One such shared partner is characterized by crystallographic studies of a complex involving cereblon (CRBN... | |
medium_convergence_04698 | PARP1 and EGFR share common interacting partners. One such partner is a RING-between-RING (RBR)-type E3 ubiquitin ligase that interacts with PARP1 through its carboxy-terminal region containing the transmembrane domain, targeting PARP1 for ubiquitination and subsequent proteasomal degradation. Which protein is encoded ... | E3 ubiquitin-protein ligase RNF144A | Medium | convergence | {"qa_id":"medium_convergence_04698","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and EGFR share common interacting partners. One such partner is a RING-between-RING (RBR)-type E3 ubiquitin ligase that interacts with PARP1 through it... | |
medium_convergence_04699 | HLA-C and B2M each interact with more than one shared protein partner. Evidence concerning one such shared partner reports that the binding of a fusion protein containing this partner to non-glycosylated mutant HLA-Cw4- or -Cw6-expressing cells was markedly decreased compared to wild-type-expressing cells. Which diseas... | multiple sclerosis | Medium | convergence | {"qa_id":"medium_convergence_04699","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HLA-C and B2M each interact with more than one shared protein partner. Evidence concerning one such shared partner reports that the binding of a fusion prote... | |
medium_convergence_04700 | Triprolidine and Ethanol both interact with a specific drug. Evidence regarding this drug states: 'Addition of ethanol to treatment with the newer hypnosedatives resulted in additive sedative effects without altering the pharmacokinetic parameters of the drugs.' Which disease is this drug indicated for? | insomnia | Medium | convergence | {"qa_id":"medium_convergence_04700","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Triprolidine and Ethanol both interact with a specific drug. Evidence regarding this drug states: 'Addition of ethanol to treatment with the newer hypnosedat... | |
medium_convergence_04701 | YAP1 and NXF1 both interact with a common protein partner. Experimental evidence indicates that this shared partner interacts with YAP via its WW1 domain and with p53BP-2 via its SH3 domain in both in vitro and in vivo settings. Which protein product is encoded by this shared partner gene? | Apoptosis-stimulating of p53 protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04701","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and NXF1 both interact with a common protein partner. Experimental evidence indicates that this shared partner interacts with YAP via its WW1 domain and... | |
medium_convergence_04702 | MDM2 and UBA1 both interact with a specific shared protein. Evidence indicates that RAD6 forms a ternary complex with this shared protein and p53, a process that contributes to the degradation of p53. Which protein is encoded by this shared entity? | Ubiquitin-conjugating enzyme E2 A | Medium | convergence | {"qa_id":"medium_convergence_04702","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and UBA1 both interact with a specific shared protein. Evidence indicates that RAD6 forms a ternary complex with this shared protein and p53, a process ... | |
medium_convergence_04703 | Human alphaherpesvirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 3.09 and an adjusted p-value of approximately 0.0058. Which protein is encoded by this gene? | ATPase family AAA domain-containing protein 5 | Medium | convergence | {"qa_id":"medium_convergence_04703","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) ... | |
medium_convergence_04704 | Hepacivirus C and Dengue virus both downregulate a specific gene. Experimental evidence for this shared target reports a log2 fold change of approximately -1.67 and an adjusted p-value of 0.0169. Which protein is encoded by this gene? | Gamma-aminobutyric acid receptor-associated protein-like 1 | Medium | convergence | {"qa_id":"medium_convergence_04704","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Dengue virus both downregulate a specific gene. Experimental evidence for this shared target reports a log2 fold change of approximately -1... | |
medium_convergence_04706 | CDK2 and PARP1 share a common interaction partner. Evidence indicates that this shared entity forms complexes with Cyclin A and Cyclin E, which phosphorylate a transcription factor in a cell-free system at the same sites as in intact cells. Which gene does this shared entity bind to? | RBBP4 | Medium | convergence | {"qa_id":"medium_convergence_04706","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and PARP1 share a common interaction partner. Evidence indicates that this shared entity forms complexes with Cyclin A and Cyclin E, which phosphorylate... | |
medium_convergence_04707 | HDAC1 and MITF both interact with a shared protein partner. Evidence indicates that a subset of mutations in this partner leads to decreased interaction with HDAC1-associated proteins RbAp48 and mSin3A. Which protein is encoded by the gene corresponding to this shared partner? | Paired amphipathic helix protein Sin3a | Medium | convergence | {"qa_id":"medium_convergence_04707","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and MITF both interact with a shared protein partner. Evidence indicates that a subset of mutations in this partner leads to decreased interaction with... | |
medium_convergence_04708 | Both Influenza A virus and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of -1.551 and an adjusted p-value of 1.149e-08. Which disease is associated with this gene through genomic alterations? | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04708","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Zaire ebolavirus are known to downregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of -... | |
medium_convergence_04709 | FANCC and DCLRE1A both interact with a shared protein. Evidence regarding this shared protein states: 'The N terminus appears to stabilize the interaction with FANCA and FANCG and is essential for the binding of the FANCC/FANCE subcomplex.' Which protein is encoded by the gene corresponding to this shared entity? | Fanconi anemia group F protein | Medium | convergence | {"qa_id":"medium_convergence_04709","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCC and DCLRE1A both interact with a shared protein. Evidence regarding this shared protein states: 'The N terminus appears to stabilize the interaction wi... | |
medium_convergence_04710 | MYC and SLX4 share a common interacting partner. Evidence indicates that this shared entity is a deubiquitinase that directly binds to MYC, resulting in MYC's deubiquitination and stabilization. Which disease is associated with this shared entity? | Leber congenital amaurosis 19 | Medium | convergence | {"qa_id":"medium_convergence_04710","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and SLX4 share a common interacting partner. Evidence indicates that this shared entity is a deubiquitinase that directly binds to MYC, resulting in MYC'... | |
medium_convergence_04711 | AKT1 and ETV4 share common interaction partners. One such partner is described in evidence stating: 'We showed that the PEA3 transcriptional factor interacted with a serine/threonine kinase, which is somatically mutated in lung cancer.' Which protein is encoded by the gene corresponding to this entity? | Serine/threonine-protein kinase STK11 | Medium | convergence | {"qa_id":"medium_convergence_04711","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and ETV4 share common interaction partners. One such partner is described in evidence stating: 'We showed that the PEA3 transcriptional factor interacte... | |
medium_convergence_04713 | YAP1 and YWHAQ both interact with a shared protein. Experimental evidence indicates that this shared protein is co-immunoprecipitated with YAP1. Which protein is encoded by the gene corresponding to this shared entity? | Serine/threonine-protein kinase Nek1 | Medium | convergence | {"qa_id":"medium_convergence_04713","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and YWHAQ both interact with a shared protein. Experimental evidence indicates that this shared protein is co-immunoprecipitated with YAP1. Which protei... | |
medium_convergence_04714 | CTBP1 and AR both interact with a specific shared protein. Evidence concerning this shared entity reports that amino acid sequence analysis predicted two potential CtBP binding sites, and indeed CtBP binding to this entity and association of CtBP with the entity/G9a/GLP complex was observed. Which protein is encoded by... | Protein Wiz | Medium | convergence | {"qa_id":"medium_convergence_04714","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and AR both interact with a specific shared protein. Evidence concerning this shared entity reports that amino acid sequence analysis predicted two pot... | |
medium_convergence_04715 | Omeprazole and Cetirizine both interact with a specific drug. Clinical evidence regarding this drug notes that five cases were caused by interactions between it and other antiepileptic drugs, etravirine-based antiretroviral therapy, omeprazole, or meropenem. What disease is this drug indicated for? | epilepsy | Medium | convergence | {"qa_id":"medium_convergence_04715","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Omeprazole and Cetirizine both interact with a specific drug. Clinical evidence regarding this drug notes that five cases were caused by interactions between... | |
medium_convergence_04716 | EPRS1 and MARS both interact with a shared protein partner. Evidence regarding this partner states: 'The EPRS repeats also showed the binding activity to the N-terminal motif of arginyl-tRNA synthetase as well as to various nucleic acids, including tRNA.' Which protein is encoded by the gene corresponding to this share... | Arginine--tRNA ligase, cytoplasmic | Medium | convergence | {"qa_id":"medium_convergence_04716","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPRS1 and MARS both interact with a shared protein partner. Evidence regarding this partner states: 'The EPRS repeats also showed the binding activity to the... | |
medium_convergence_04717 | HRAS and KRAS both interact with a specific protein. Evidence indicates that Ras transforming activity correlates best with the ability of the encoded protein to interact with this partner. Which protein is encoded by the gene corresponding to this interacting partner? | RAF proto-oncogene serine/threonine-protein kinase | Medium | convergence | {"qa_id":"medium_convergence_04717","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HRAS and KRAS both interact with a specific protein. Evidence indicates that Ras transforming activity correlates best with the ability of the encoded protei... | |
medium_convergence_04718 | ERCC3 and CCNK share multiple binding partners. One shared partner is identified by evidence stating: 'Protein affinity assays demonstrate that TFIIE binds directly to ERCC-3, a DNA repair protein associated with TFIIH.' Which disease is associated with this specific shared partner? | trichothiodystrophy 6, nonphotosensitive | Medium | convergence | {"qa_id":"medium_convergence_04718","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC3 and CCNK share multiple binding partners. One shared partner is identified by evidence stating: 'Protein affinity assays demonstrate that TFIIE binds d... | |
medium_convergence_04719 | COPG1 and ANK1 each share a binding partner. Evidence concerning one such shared partner states: 'Yeast two-hybrid analysis indicates that gamma1- and gamma2-COPs can directly, albeit promiscuously, interact with zeta1- and zeta2-COPs.' Which protein is encoded by that shared partner? | Coatomer subunit zeta-2 | Medium | convergence | {"qa_id":"medium_convergence_04719","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPG1 and ANK1 each share a binding partner. Evidence concerning one such shared partner states: 'Yeast two-hybrid analysis indicates that gamma1- and gamma2... | |
medium_convergence_04720 | CEP162 and CDK1 both interact with a shared protein. Evidence indicates that this shared protein binds to and recruits CDK1 to centrosomes, thereby regulating mitotic entry. Which protein is encoded by the gene corresponding to this shared entity? | Centrosomal protein of 63 kDa | Medium | convergence | {"qa_id":"medium_convergence_04720","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEP162 and CDK1 both interact with a shared protein. Evidence indicates that this shared protein binds to and recruits CDK1 to centrosomes, thereby regulatin... | |
medium_convergence_04721 | Both GRB2 and GRB7 interact with a specific receptor tyrosine kinase. Experimental evidence indicates that the binding of GRB2 to this receptor is strictly dependent on intact phosphorylation sites Y703 and Y936. Which protein is encoded by the gene corresponding to this receptor? | Mast/stem cell growth factor receptor Kit | Medium | convergence | {"qa_id":"medium_convergence_04721","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both GRB2 and GRB7 interact with a specific receptor tyrosine kinase. Experimental evidence indicates that the binding of GRB2 to this receptor is strictly d... | |
medium_convergence_04722 | STRA13 and CENPS each interact with more than one shared protein. One of these shared proteins is a Fanconi anemia (FA) protein that associates with the histone-fold complex MHF to form a branched DNA remodeling complex. This complex senses and repairs stalled replication forks and activates the FA DNA damage response ... | Fanconi anemia group M protein | Medium | convergence | {"qa_id":"medium_convergence_04722","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STRA13 and CENPS each interact with more than one shared protein. One of these shared proteins is a Fanconi anemia (FA) protein that associates with the hist... | |
medium_convergence_04723 | EGFR and EWSR1 share a common interacting partner. Experimental evidence indicates that carbachol (100 microM) stimulates the tyrosine phosphorylation and association of the Ca(2+)-dependent tyrosine kinase PYK-2 with this shared entity, an effect that is inhibited by the Ca(2+) chelator BAPTA (20 microM). Which diseas... | alcohol abuse | Medium | convergence | {"qa_id":"medium_convergence_04723","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and EWSR1 share a common interacting partner. Experimental evidence indicates that carbachol (100 microM) stimulates the tyrosine phosphorylation and as... | |
medium_convergence_04724 | Cardiovirus A and Zika virus both upregulate a specific gene in cervical adenocarcinoma cells. Experimental data for this gene shows a log2 fold change of approximately 2.63 and an adjusted p-value of 0.0319. Which protein is encoded by this gene? | Interleukin-36 gamma | Medium | convergence | {"qa_id":"medium_convergence_04724","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cardiovirus A and Zika virus both upregulate a specific gene in cervical adenocarcinoma cells. Experimental data for this gene shows a log2 fold change of ap... | |
medium_convergence_04725 | Both Human alphaherpesvirus 1 and Dengue virus have been shown to upregulate a specific gene in monocytic leukemia cell lines (study GSE114966). For one such shared target, the reported log2 fold change is approximately 1.295 and the adjusted p-value is 0.003503. Which protein is encoded by this gene? | Exosome complex component RRP45 | Medium | convergence | {"qa_id":"medium_convergence_04725","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Dengue virus have been shown to upregulate a specific gene in monocytic leukemia cell lines (study GSE114966). For one such... | |
medium_convergence_04726 | Cardiovirus A and Pegivirus C both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately 2.63 and an adjusted p-value of 0.0319. Which protein is encoded by this gene? | Interleukin-36 gamma | Medium | convergence | {"qa_id":"medium_convergence_04726","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cardiovirus A and Pegivirus C both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) repor... | |
medium_convergence_04727 | CSNK1D and DVL1 both interact with a shared protein. Experimental evidence indicates that the DIX domain of Dvl-1 interacts with Dvl-3, identified as a second mammalian Dishevelled relative. Which protein is encoded by this shared entity? | Segment polarity protein dishevelled homolog DVL-3 | Medium | convergence | {"qa_id":"medium_convergence_04727","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK1D and DVL1 both interact with a shared protein. Experimental evidence indicates that the DIX domain of Dvl-1 interacts with Dvl-3, identified as a secon... | |
medium_convergence_04728 | Vaccinia virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.012 and an adjusted p-value of 0.0005001. Which disease is associated with this gene as a biomarker? | hypertensive disorder | Medium | convergence | {"qa_id":"medium_convergence_04728","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) re... | |
medium_convergence_04729 | CALR3 and EFEMP1 share multiple interacting partners. One of these shared partners is part of a set of eight interactions (including ANXA5, ERdj5, PDIA4, PDIA6, and others) that were verified at the western blotting level. Which protein is encoded by this specific shared partner? | Protein disulfide-isomerase | Medium | convergence | {"qa_id":"medium_convergence_04729","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CALR3 and EFEMP1 share multiple interacting partners. One of these shared partners is part of a set of eight interactions (including ANXA5, ERdj5, PDIA4, PDI... | |
medium_convergence_04730 | YWHAQ and ECD share common interaction partners. One such shared partner is described in evidence stating that it competitively binds to hnRNP F via its N-terminal STG1 domain (residues 13-383), thereby preventing hnRNP F from interacting with ZFP91 and blocking ZFP91-mediated ubiquitination and proteasomal degradation... | Heterogeneous nuclear ribonucleoprotein F | Medium | convergence | {"qa_id":"medium_convergence_04730","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and ECD share common interaction partners. One such shared partner is described in evidence stating that it competitively binds to hnRNP F via its N-te... | |
medium_convergence_04731 | NUP107 and NUP153 both interact with a specific shared protein. Experimental evidence for this shared protein states: 'We have also examined interactions between this protein and the NPC and found specific two-hybrid interactions between this protein and several well-defined components of the NPC, as well as coimmunopr... | Nuclear pore complex protein Nup50 | Medium | convergence | {"qa_id":"medium_convergence_04731","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUP107 and NUP153 both interact with a specific shared protein. Experimental evidence for this shared protein states: 'We have also examined interactions bet... | |
medium_convergence_04732 | Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately -2.30 and an adjusted p-value of approximately 0.034. Which protein does this gene product interact with? | RAB5B | Medium | convergence | {"qa_id":"medium_convergence_04732","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold... | |
medium_convergence_04733 | ADRB1 and GNB2 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We show first that the mammalian beta1 and gamma3 fusion proteins form a complex in yeast and that formation of the complex activates the reporter gene for beta-galactosidase.' Which protein is connected... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 | Medium | convergence | {"qa_id":"medium_convergence_04733","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADRB1 and GNB2 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We show first that the mammalian beta1 a... | |
medium_convergence_04734 | SHC1 and SOS1 both interact with a common protein partner. Evidence regarding one such partner states: 'Here we report the identification of an interaction between the adapter protein ShcA and the cytoplasmic domain of the receptor encoded by TEK through in vitro co-immunoprecipitation analysis.' Which protein is encod... | Angiopoietin-1 receptor | Medium | convergence | {"qa_id":"medium_convergence_04734","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SHC1 and SOS1 both interact with a common protein partner. Evidence regarding one such partner states: 'Here we report the identification of an interaction b... | |
medium_convergence_04736 | HSPA1B and HSPA4 both interact with a specific shared protein. Experimental evidence indicates that HSP70 binds to this protein, and in vitro, the conversion of this protein's chains into monomeric forms stimulates HSP70 ATPase activity. Which protein is encoded by the gene corresponding to this shared entity? | Ubiquitin-like protein NEDD8 | Medium | convergence | {"qa_id":"medium_convergence_04736","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA1B and HSPA4 both interact with a specific shared protein. Experimental evidence indicates that HSP70 binds to this protein, and in vitro, the conversion... | |
medium_convergence_04739 | KAT5 and HDAC2 both interact with a shared protein. Evidence regarding one such shared entity states: 'We also show that Tip60 associates with this entity through its N-terminal zinc finger-containing region and that this entity's activity is required for the repressive effect of Tip60.' Which cell type is this entity ... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_04739","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and HDAC2 both interact with a shared protein. Evidence regarding one such shared entity states: 'We also show that Tip60 associates with this entity th... | |
medium_convergence_04741 | NEDD4L and CHMP6 both interact with a specific protein. Experimental evidence involving double and triple immunofluorescence, proximity ligation immunofluorescence, and co-immunoprecipitation indicates that this protein associates with KSHV-containing macropinosomes. Furthermore, in KSHV-infected cells, this protein sh... | Tumor susceptibility gene 101 protein | Medium | convergence | {"qa_id":"medium_convergence_04741","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4L and CHMP6 both interact with a specific protein. Experimental evidence involving double and triple immunofluorescence, proximity ligation immunofluore... | |
medium_convergence_04742 | MDM2 and SQSTM1 share common interacting partners. One such shared partner physically interacts with MDM2 and promotes ATM-mediated inhibitory phosphorylation of MDM2 following ionizing radiation. Which protein is encoded by this shared partner? | Nonsense-mediated mRNA decay factor SMG7 | Medium | convergence | {"qa_id":"medium_convergence_04742","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and SQSTM1 share common interacting partners. One such shared partner physically interacts with MDM2 and promotes ATM-mediated inhibitory phosphorylatio... | |
medium_convergence_04743 | ESR1 and PLK1 both interact with a shared gene product. Evidence for one such shared entity states: 'An in vivo association between full-length [the protein product of the shared gene] and ERalpha was observed in HEK 293 cells and ELT-3 smooth muscle cells.' Which disease is therapeutically connected to that specific e... | renal cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04743","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and PLK1 both interact with a shared gene product. Evidence for one such shared entity states: 'An in vivo association between full-length [the protein ... | |
medium_convergence_04744 | Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately 2.28 and an adjusted p-value of 0.04055. Which protein does this gene product bind to? | IL25 | Medium | convergence | {"qa_id":"medium_convergence_04744","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold... | |
medium_convergence_04745 | GNAI3 and GNA14 each interact with more than one shared protein. Evidence concerning one of these shared proteins reports that it was shown to interact specifically with the G(alphai-3) subunit in membranes from K562 cells. Which cell type is that shared protein enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_04745","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI3 and GNA14 each interact with more than one shared protein. Evidence concerning one of these shared proteins reports that it was shown to interact speci... | |
medium_convergence_04746 | CNTROB and CNOT1 both interact with a shared protein entity. Evidence indicates that human GW182 proteins recruit the PAN2-PAN3 and CCR4-CAF1-NOT deadenylase complexes through direct interactions with PAN3 and NOT1, respectively. Which cell type is this shared entity enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_04746","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CNTROB and CNOT1 both interact with a shared protein entity. Evidence indicates that human GW182 proteins recruit the PAN2-PAN3 and CCR4-CAF1-NOT deadenylase... | |
medium_convergence_04747 | ATF7IP and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Notably, acetylated this protein binds to histone H3 phosphorylation at threonine 11 (H3T11P) and is essential for DNA damage-induced reduction of H3T11P and transcriptional repression of its downstream targ... | ATPase MORC2 | Medium | convergence | {"qa_id":"medium_convergence_04747","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATF7IP and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Notably, acetylated this protein binds to hi... | |
medium_convergence_04748 | IL1B and IL1R1 share a common interaction partner. Experimental evidence indicates that when human embryonic kidney cells (HEK293) over-expressing IL-1RI or HeLa cells are exposed to IL-1, this shared partner rapidly associates with the IL-1RI complex and undergoes phosphorylation. Which protein is encoded by the gene ... | Interleukin-1 receptor-associated kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_04748","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL1B and IL1R1 share a common interaction partner. Experimental evidence indicates that when human embryonic kidney cells (HEK293) over-expressing IL-1RI or ... | |
medium_convergence_04749 | CKAP4 and DMBT1 both interact with a specific protein. Evidence regarding this protein states: 'We have shown that soluble gp-340 binds a surfactant protein A family member in a calcium-dependent manner independent of the lectin activity of that protein.' Which biological process is this protein involved in? | opsonization | Medium | convergence | {"qa_id":"medium_convergence_04749","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CKAP4 and DMBT1 both interact with a specific protein. Evidence regarding this protein states: 'We have shown that soluble gp-340 binds a surfactant protein ... | |
medium_convergence_04750 | Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data from a study on hepatocytes (GSE135619) indicates that this gene exhibits a log2 fold change of approximately -2.136 and an adjusted p-value of 0.04032. Which prot... | CKLF-like MARVEL transmembrane domain-containing protein 8 | Medium | convergence | {"qa_id":"medium_convergence_04750","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data ... | |
medium_convergence_04751 | HSPB1 and PRKN share common interacting partners. One such shared partner is highlighted in research stating: 'As an example, we showed that targeting Hsp27 interaction with a partner protein identified in our screen increases therapy sensitivity, opening a new promising field of research for therapeutic approaches tha... | Lyme disease | Medium | convergence | {"qa_id":"medium_convergence_04751","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPB1 and PRKN share common interacting partners. One such shared partner is highlighted in research stating: 'As an example, we showed that targeting Hsp27 ... | |
medium_convergence_04752 | Human alphaherpesvirus 1 and Rhinovirus A both upregulate a specific gene. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 2.78 and an adjusted p-value of approximately 0.0108. Which disease is associated with this gene? | colon adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_04752","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Rhinovirus A both upregulate a specific gene. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports... |
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