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medium_convergence_04864 | CDC37 and HSP90AA1 both interact with a specific shared protein. Experimental evidence indicates that under basal conditions, this shared protein co-immunoprecipitates with HSP90. Which protein is encoded by this shared entity? | Tyrosine-protein kinase receptor UFO | Medium | convergence | {"qa_id":"medium_convergence_04864","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and HSP90AA1 both interact with a specific shared protein. Experimental evidence indicates that under basal conditions, this shared protein co-immunopr... | |
medium_convergence_04865 | Enterovirus A and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells shows a log2 fold change of approximately 3.58 and an adjusted p-value of 0.003. Which protein does this gene product interact with? | NHERF1 | Medium | convergence | {"qa_id":"medium_convergence_04865","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells shows a log2 fold change of approx... | |
medium_convergence_04866 | Both CYLD and BIRC3 interact with a specific shared protein. Evidence indicates that this shared protein binds to a receptor-interacting serine/threonine-protein kinase and inhibits its ubiquitination and signaling function. Which protein is encoded by the gene corresponding to this shared entity? | Receptor-interacting serine/threonine-protein kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_04866","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both CYLD and BIRC3 interact with a specific shared protein. Evidence indicates that this shared protein binds to a receptor-interacting serine/threonine-pro... | |
medium_convergence_04867 | MAPK3 and KSR1 share a common binding partner. Evidence indicates that C-TAK1 constitutively associates with this shared entity, phosphorylating serine 392 to facilitate 14-3-3 binding and cytoplasmic sequestration in unstimulated cells. Which cell type is enriched for this shared entity? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_04867","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK3 and KSR1 share a common binding partner. Evidence indicates that C-TAK1 constitutively associates with this shared entity, phosphorylating serine 392 t... | |
medium_convergence_04868 | GTF3A and GTF3C2 both interact with a shared protein partner. Evidence regarding this partner describes novel interactions of hTFIIIC63 with hTFIIIC102, hTFIIIB90, and hRPC62, as well as hTFIIIC102-hTFIIIB90 and hTFIIIB90-hRPC39 interactions that parallel those previously described in yeast. Which disease is associated... | neurodevelopmental disorder with dysmorphic facies, brain anomalies, and seizures | Medium | convergence | {"qa_id":"medium_convergence_04868","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF3A and GTF3C2 both interact with a shared protein partner. Evidence regarding this partner describes novel interactions of hTFIIIC63 with hTFIIIC102, hTFI... | |
medium_convergence_04869 | Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Evidence for this gene in foreskin fibroblast cell lines (study GSE132081) reports a log2 fold change of approximately 1.006 and an adjusted p-value of 0.0003189. Which disease is associated with this gene as a biomarker? | obsessive-compulsive disorder | Medium | convergence | {"qa_id":"medium_convergence_04869","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Evidence for this gene in foreskin fibroblast cell lines (study GSE132081) reports ... | |
medium_convergence_04870 | Both Influenza A virus and Dengue virus are known to upregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of approximately 1.717 and an adjusted p-value of 0.007509. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_04870","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Dengue virus are known to upregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of approxi... | |
medium_convergence_04871 | CFTR and FGFR1 share common interacting partners. One such shared partner is characterized by evidence stating: 'We report that immature ER forms of CFTR and DeltaF508 CFTR can be isolated in complexes with this protein and Hsc70.' Which protein is encoded by this shared interacting partner? | DnaJ homolog subfamily A member 1 | Medium | convergence | {"qa_id":"medium_convergence_04871","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CFTR and FGFR1 share common interacting partners. One such shared partner is characterized by evidence stating: 'We report that immature ER forms of CFTR and... | |
medium_convergence_04872 | COMMD1 and CUL5 both interact with a specific shared protein. Evidence indicates that this protein is involved in the formation of a novel E3 ligase through interaction with the CUL5-ELOB/C-RNF7 complex, and that deleterious variants affect the binding amount of this protein and CUL5. Which cellular component is this s... | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_04872","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL5 both interact with a specific shared protein. Evidence indicates that this protein is involved in the formation of a novel E3 ligase through ... | |
medium_convergence_04873 | FBXO7 and UBQLN2 both interact with a specific shared protein. Experimental evidence indicates that this shared protein was identified as a binding partner of FBXO7 through a yeast two-hybrid screen of a human fetal brain library, where it was described as the neurotrophin receptor-interacting MAGE protein. Which prote... | Melanoma-associated antigen D1 | Medium | convergence | {"qa_id":"medium_convergence_04873","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXO7 and UBQLN2 both interact with a specific shared protein. Experimental evidence indicates that this shared protein was identified as a binding partner o... | |
medium_convergence_04874 | ACTR3 and WAS both interact with a shared protein partner. Evidence regarding one such partner states: 'By using the yeast two-hybrid system we have identified a proline-rich WASP-interacting protein, which coimmunoprecipitated with WASP from lymphocytes.' Which protein is encoded by the gene corresponding to this spec... | WAS/WASL-interacting protein family member 1 | Medium | convergence | {"qa_id":"medium_convergence_04874","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR3 and WAS both interact with a shared protein partner. Evidence regarding one such partner states: 'By using the yeast two-hybrid system we have identifi... | |
medium_convergence_04875 | EHMT2 and BRD4 share a common interaction partner. Evidence regarding this shared partner states: 'Here we show that the protein binds histone lysine methyltransferase G9a, and both are co-localized in the nucleus in a cell-cycle-dependent manner.' Which protein is encoded by this shared interaction partner? | E3 ubiquitin-protein ligase UHRF1 | Medium | convergence | {"qa_id":"medium_convergence_04875","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and BRD4 share a common interaction partner. Evidence regarding this shared partner states: 'Here we show that the protein binds histone lysine methylt... | |
medium_convergence_04876 | EGFR and SFN share multiple interacting partners. One such shared partner is listed among the 15 entities with direct interactions recorded in the iRefIndex database, a list that includes Grb2, shc-1, SOS1 and 2, STAT 1 and 3, AP2, UBS3B, and ERRFI. Which protein is encoded by this specific shared entity? | ERBB receptor feedback inhibitor 1 | Medium | convergence | {"qa_id":"medium_convergence_04876","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and SFN share multiple interacting partners. One such shared partner is listed among the 15 entities with direct interactions recorded in the iRefIndex ... | |
medium_convergence_04877 | ERBB2 and ERBB4 share binding partners. One such shared partner is described in evidence stating: 'Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and the ErbB4-receptor tyrosine kinases.' Which protein is encoded by this shared binding partner? | Pro-neuregulin-2, membrane-bound isoform | Medium | convergence | {"qa_id":"medium_convergence_04877","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and ERBB4 share binding partners. One such shared partner is described in evidence stating: 'Like NRG-1, the EGF-like domain of the new ligands binds t... | |
medium_convergence_04878 | SEC63 and CTNNB1 share multiple interacting partners. One such partner is known to interact with beta-catenin via a conserved adenomatous polyposis coli (APC)-like domain. Which disease is associated with this specific partner as a biomarker? | plasma cell myeloma | Medium | convergence | {"qa_id":"medium_convergence_04878","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SEC63 and CTNNB1 share multiple interacting partners. One such partner is known to interact with beta-catenin via a conserved adenomatous polyposis coli (APC... | |
medium_convergence_04879 | LRP6 and LGR5 both interact with a shared protein partner. Evidence regarding one such partner describes the reporting of a low-resolution hLGR5-mRspo2Fu1-Fu2-m[Partner]ecto ternary complex structure. Which protein is encoded by this specific partner? | E3 ubiquitin-protein ligase ZNRF3 | Medium | convergence | {"qa_id":"medium_convergence_04879","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LRP6 and LGR5 both interact with a shared protein partner. Evidence regarding one such partner describes the reporting of a low-resolution hLGR5-mRspo2Fu1-Fu... | |
medium_convergence_04880 | Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.180 and an adjusted p-value of 0.007882. In which cellular component is this gene product located? | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_04880","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114... | |
medium_convergence_04881 | IL2 and PTPRC are both involved in more than one shared biological process. Evidence indicates that B cells respond to IL-10 by proliferating and differentiating, and that IL-2 and IL-10 have an additive or synergistic effect. Which biological process, connected to this shared entity via the 'positively regulates' rela... | B cell proliferation | Medium | convergence | {"qa_id":"medium_convergence_04881","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL2 and PTPRC are both involved in more than one shared biological process. Evidence indicates that B cells respond to IL-10 by proliferating and differentia... | |
medium_convergence_04882 | Both Human betaherpesvirus 5 and Human mastadenovirus C are associated with the downregulation of a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately -1.11 and an adjusted p-value of 0.047. Which protein is encoded by this gene? | Chromobox protein homolog 5 | Medium | convergence | {"qa_id":"medium_convergence_04882","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human betaherpesvirus 5 and Human mastadenovirus C are associated with the downregulation of a specific gene. Experimental data for this gene in foreski... | |
medium_convergence_04883 | OS9 and SEL1L both interact with a specific protein. Evidence states: 'We also identify the ERAD components SEL1L, OS-9 and ERdj5, a known reductase of ERAD substrates, as interaction partners of [the target protein].' Based on this evidence, which protein is the shared interaction partner mentioned, and what protein p... | FAD-dependent oxidoreductase domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04883","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OS9 and SEL1L both interact with a specific protein. Evidence states: 'We also identify the ERAD components SEL1L, OS-9 and ERdj5, a known reductase of ERAD ... | |
medium_convergence_04884 | VAMP2 and VAMP8 are both involved in a shared biological process. Evidence indicates that anti-VAMP-2 modestly and selectively impaired secretion from small granules and vesicles. Which cell type is the site of this specific biological process? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_04884","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VAMP2 and VAMP8 are both involved in a shared biological process. Evidence indicates that anti-VAMP-2 modestly and selectively impaired secretion from small ... | |
medium_convergence_04885 | TRIM28 and HDAC1 both interact with a specific shared protein. Evidence indicates that the activation of E2F transcription factors is mechanistically linked to this shared protein's ability to interact with the E2F inhibitor HDAC1. Which protein is encoded by the gene corresponding to this shared entity? | Melanoma-associated antigen B2 | Medium | convergence | {"qa_id":"medium_convergence_04885","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and HDAC1 both interact with a specific shared protein. Evidence indicates that the activation of E2F transcription factors is mechanistically linked ... | |
medium_convergence_04886 | EGFR and FGFR1 share multiple interacting partners. One such shared partner is described in evidence stating: 'When expressed in COS7 cells, epitope-tagged sorting nexins SNX1, SNX1A, this protein, and SNX4 coimmunoprecipitated with receptor tyrosin kinases for EGF, platelet-derived growth factor, and insulin.' Which p... | Sorting nexin-2 | Medium | convergence | {"qa_id":"medium_convergence_04886","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and FGFR1 share multiple interacting partners. One such shared partner is described in evidence stating: 'When expressed in COS7 cells, epitope-tagged s... | |
medium_convergence_04887 | Human betaherpesvirus 5 and Human polyomavirus 1 both upregulate a specific gene. Evidence for this gene reports a log2 fold change of 1.019 and an adjusted p-value of 0.007212. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_04887","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human polyomavirus 1 both upregulate a specific gene. Evidence for this gene reports a log2 fold change of 1.019 and an adjusted ... | |
medium_convergence_04888 | Rhinovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene shows a log2 fold change of approximately 1.76 and an adjusted p-value of 0.0134. Which cellular component is this gene located in? | basal plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_04888","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene shows a log2 fold change of approximately 1.76 and an adjusted p-value... | |
medium_convergence_04890 | SEPTIN9 and SEPT8 each interact with more than one shared gene. Evidence concerning one shared entity reports that SEPT9 is part of the core septin hetero-octamer in human cells, which is composed of this entity, SEPT6, SEPT7, and SEPT9. Which disease is connected to this entity through genomic alterations? | myelodysplastic syndrome | Medium | convergence | {"qa_id":"medium_convergence_04890","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SEPTIN9 and SEPT8 each interact with more than one shared gene. Evidence concerning one shared entity reports that SEPT9 is part of the core septin hetero-oc... | |
medium_convergence_04891 | HNF4A and HSP90AA1 share common interaction partners. One such partner is implicated in a study where Rifampicin strongly stimulated its interaction with hepatocyte nuclear factor 4alpha (HNF4alpha) and CYP3A4 reporter activity. This activity was further stimulated by PGC-1alpha and SRC-1 but inhibited by SHP. Which pr... | Nuclear receptor subfamily 1 group I member 2 | Medium | convergence | {"qa_id":"medium_convergence_04891","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HNF4A and HSP90AA1 share common interaction partners. One such partner is implicated in a study where Rifampicin strongly stimulated its interaction with hep... | |
medium_convergence_04892 | TRIM28 and MYC share multiple interacting partners. One such shared partner is characterized by evidence stating that it attenuates FBXW7-mediated ubiquitination and degradation of MYC by directly binding to the MYC homology box 1 domain, competing with FBXW7. Which protein is encoded by this shared interacting partner... | DNA polymerase delta catalytic subunit | Medium | convergence | {"qa_id":"medium_convergence_04892","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and MYC share multiple interacting partners. One such shared partner is characterized by evidence stating that it attenuates FBXW7-mediated ubiquitina... | |
medium_convergence_04893 | SIRT1 and SIN3A both interact with a specific transcriptional repressor. Evidence indicates that this repressor, along with PLZF, can interact with corepressor proteins including mSin3A and histone deacetylase-1. Which disease is connected to this repressor through genomic alterations? | gonorrhea | Medium | convergence | {"qa_id":"medium_convergence_04893","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIRT1 and SIN3A both interact with a specific transcriptional repressor. Evidence indicates that this repressor, along with PLZF, can interact with corepress... | |
medium_convergence_04894 | HOXA1 and NEUROG1 are both involved in more than one shared biological process. One of these shared processes is associated with a phenotype characterized by horizontal gaze abnormalities, deafness, facial weakness, hypoventilation, vascular malformations of the internal carotid arteries and cardiac outflow tract, ment... | ear development | Medium | convergence | {"qa_id":"medium_convergence_04894","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HOXA1 and NEUROG1 are both involved in more than one shared biological process. One of these shared processes is associated with a phenotype characterized by... | |
medium_convergence_04895 | TAB1 and MAP3K7 share multiple binding partners. Evidence regarding one specific shared partner describes a complex containing TAK1, TAB1, and this partner, as well as another complex containing TAK1, TAB1, and TAB3. Which cell type is enriched for this specific shared partner? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_04895","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TAB1 and MAP3K7 share multiple binding partners. Evidence regarding one specific shared partner describes a complex containing TAK1, TAB1, and this partner, ... | |
medium_convergence_04897 | Moxifloxacin and Bleomycin share a common interacting drug. Evidence regarding this shared entity indicates that synergism between the drugs when administered concurrently produces pulmonary toxicity at lower doses. Which disease is this shared drug indicated for? | lymphosarcoma | Medium | convergence | {"qa_id":"medium_convergence_04897","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Moxifloxacin and Bleomycin share a common interacting drug. Evidence regarding this shared entity indicates that synergism between the drugs when administere... | |
medium_convergence_04898 | CLTC and AP2B1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'A highly conserved 20-amino acid sequence in the C-terminal region of a specific adapter protein bound the beta(2)-adaptin subunit of AP-2.' Which protein is connected to that entity through the 'encodes' rel... | Low density lipoprotein receptor adapter protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04898","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLTC and AP2B1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'A highly conserved 20-amino acid sequence in ... | |
medium_convergence_04899 | CHUK and BIRC3 each share more than one binding partner. Evidence concerning one shared entity reports that a protein encoded by this entity interacts preferentially with IKK-beta and is required for the activation of the IKK complex. Which protein is connected to that entity through the 'encodes' relationship? | NF-kappa-B essential modulator | Medium | convergence | {"qa_id":"medium_convergence_04899","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and BIRC3 each share more than one binding partner. Evidence concerning one shared entity reports that a protein encoded by this entity interacts prefer... | |
medium_convergence_04900 | Interleukin-6 (IL6) and Interleukin-18 (IL18) are both involved in a shared biological process. Evidence regarding this process states: 'The inflammatory cytokine, interleukin (IL)6, appears to play a critical role in both the development of the Th17 response and the inhibition of Treg functions.' Which biological proc... | interleukin-17 production | Medium | convergence | {"qa_id":"medium_convergence_04900","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Interleukin-6 (IL6) and Interleukin-18 (IL18) are both involved in a shared biological process. Evidence regarding this process states: 'The inflammatory cyt... | |
medium_convergence_04902 | Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 fold change of approximately 1.079 and an adjusted p-value of 0.02356. Which protein is encoded by this gene? | Protein mono-ADP-ribosyltransferase PARP12 | Medium | convergence | {"qa_id":"medium_convergence_04902","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 ... | |
medium_convergence_04903 | EP300 and CCDC22 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Inhibitors of Fe(II)- and 2-oxoglutarate-dependent dioxygenases prevented hydroxylation of the Asn, thus allowing the CAD to interact with the p300 transcription coactivator.' Which protein is c... | Hypoxia-inducible factor 1-alpha | Medium | convergence | {"qa_id":"medium_convergence_04903","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and CCDC22 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Inhibitors of Fe(II)- and 2-oxo... | |
medium_convergence_04904 | MAPK8 and MAP2K7 share a common binding partner. Evidence indicates that this shared entity is a putative scaffold protein interacting with multiple components of the JNK signaling pathway, including MLK, MKK7, and JNK. Which protein is encoded by this shared entity? | C-Jun-amino-terminal kinase-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04904","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK8 and MAP2K7 share a common binding partner. Evidence indicates that this shared entity is a putative scaffold protein interacting with multiple componen... | |
medium_convergence_04905 | ANAPC2 and ANAPC5 each interact with more than one shared partner. Evidence concerning one shared partner reports that the carboxy-terminal tail of Emi1 antagonizes chain elongation by this entity, by competitively preventing its binding to the APC cullin subunit through electrostatic interaction. Which cellular compon... | anaphase-promoting complex | Medium | convergence | {"qa_id":"medium_convergence_04905","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC2 and ANAPC5 each interact with more than one shared partner. Evidence concerning one shared partner reports that the carboxy-terminal tail of Emi1 anta... | |
medium_convergence_04906 | ERBB3 and FYN each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In human breast cancer cell lines, co-immunoprecipitation of this protein with both receptors was detected upon heregulin stimulation.' Which disease is connected to that entity through genomic alterations? | carcinoma of esophagus | Medium | convergence | {"qa_id":"medium_convergence_04906","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB3 and FYN each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In human breast cancer cell lines, co-immunopr... | |
medium_convergence_04907 | YAP1 and MYBBP1A share multiple interacting partners. One specific shared partner is documented to interact with YAP1, a process that enhances CTGF expression through histone methylation. Which protein is encoded by this specific shared partner? | WD repeat-containing protein 5 | Medium | convergence | {"qa_id":"medium_convergence_04907","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and MYBBP1A share multiple interacting partners. One specific shared partner is documented to interact with YAP1, a process that enhances CTGF expressio... | |
medium_convergence_04908 | Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific shared gene entity. Experimental evidence for this entity reports a log2 fold change of 2.471 and an adjusted p-value of 0.008025. Which protein is encoded by this entity? | Histone H3.1 | Medium | convergence | {"qa_id":"medium_convergence_04908","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific shared gene entity. Experimental evidence for this entity reports a log2 fol... | |
medium_convergence_04909 | KLF1 and CDC37 share multiple interacting partners. One such partner is implicated in evidence stating: 'Third, in vitro assays demonstrate that CKIIalpha interacts with EKLF, and that the EKLF interaction domain is phosphorylated by CKII only at Thr-41; however, the CKII-site mutant is not phosphorylated.' Which prote... | Casein kinase II subunit alpha | Medium | convergence | {"qa_id":"medium_convergence_04909","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KLF1 and CDC37 share multiple interacting partners. One such partner is implicated in evidence stating: 'Third, in vitro assays demonstrate that CKIIalpha in... | |
medium_convergence_04910 | RAB4A and YWHAH share multiple interacting partners. One such partner is described in evidence stating: 'We have identified a novel 80-kDa protein that interacts specifically with the GTP-bound conformation of Rab4, and subsequent work has shown that it also interacts strongly with Rab11.' Which protein is encoded by t... | Rab11 family-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04910","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAB4A and YWHAH share multiple interacting partners. One such partner is described in evidence stating: 'We have identified a novel 80-kDa protein that inter... | |
medium_convergence_04911 | HSPA2 and HSPA4 both interact with a specific shared protein. Evidence regarding this shared entity states: 'The Kds of the interactions of a DnaJ-domain containing co-chaperone, TRP1, and HspBp1 with Hsp70 were 0.5, 0.6, and 0.04 mM, respectively.' Which protein is encoded by this shared entity? | DnaJ homolog subfamily B member 1 | Medium | convergence | {"qa_id":"medium_convergence_04911","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA2 and HSPA4 both interact with a specific shared protein. Evidence regarding this shared entity states: 'The Kds of the interactions of a DnaJ-domain con... | |
medium_convergence_04912 | CREBBP and EP300 both interact with a shared protein entity. Evidence for one such shared entity indicates that binding between purified proteins demonstrated a direct interaction. Which disease is connected to that specific entity through genomic alterations? | systemic lupus erythematosus | Medium | convergence | {"qa_id":"medium_convergence_04912","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and EP300 both interact with a shared protein entity. Evidence for one such shared entity indicates that binding between purified proteins demonstrate... | |
medium_convergence_04913 | HYPK and PRKN each interact with more than one shared gene product. Evidence concerning one shared entity reports that Human NatA (hNatA), one of six conserved metazoan N-terminal acetyltransferases, contains Naa10 catalytic and the shared entity auxiliary subunits, and associates with the intrinsically disordered Hunt... | N-alpha-acetyltransferase 15, NatA auxiliary subunit | Medium | convergence | {"qa_id":"medium_convergence_04913","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HYPK and PRKN each interact with more than one shared gene product. Evidence concerning one shared entity reports that Human NatA (hNatA), one of six conserv... | |
medium_convergence_04914 | CHD3 and RBBP7 both interact with a specific shared protein. Experimental evidence indicates that in glutathione S-transferase pull-down assays, this protein associates with several known components of the MeCP1.NuRD complex, including HDAC1, HDAC2, MTA2, MBD2, RbAp46, and RbAp48, but MBD3 is not found in the fraction ... | Methyl-CpG-binding domain protein 3-like 1 | Medium | convergence | {"qa_id":"medium_convergence_04914","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and RBBP7 both interact with a specific shared protein. Experimental evidence indicates that in glutathione S-transferase pull-down assays, this protein... | |
medium_convergence_04915 | Amikacin and Gentamicin both interact with a specific shared drug. Clinical evidence regarding this shared drug includes a trial that compared the combination of this drug plus amikacin against vancomycin plus amikacin. Which drug interacts with this shared entity? | Picosulfuric acid | Medium | convergence | {"qa_id":"medium_convergence_04915","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Amikacin and Gentamicin both interact with a specific shared drug. Clinical evidence regarding this shared drug includes a trial that compared the combinatio... | |
medium_convergence_04916 | NMU and GNA14 both interact with a specific receptor protein. Evidence indicates that radiolabeled neuromedin U binds with high affinity to membrane fractions prepared from cells expressing this receptor. Which protein is encoded by the gene corresponding to this receptor? | Neuromedin-U receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_04916","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NMU and GNA14 both interact with a specific receptor protein. Evidence indicates that radiolabeled neuromedin U binds with high affinity to membrane fraction... | |
medium_convergence_04917 | CDK9 and NXF1 share common interacting partners. One such shared partner is described as the Ski-interacting protein, which associates with the P-TEFb/CDK9 elongation factor and coactivates inducible genes, including HIV-1. Which disease is associated with this specific shared partner via a biomarker relationship? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04917","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK9 and NXF1 share common interacting partners. One such shared partner is described as the Ski-interacting protein, which associates with the P-TEFb/CDK9 e... | |
medium_convergence_04918 | VIRMA and GSK3B share common interaction partners. One such shared partner is described in evidence stating: 'We show that GSK-3β directly interacts with the E3 ubiquitin ligase identified by differential display that also binds β-catenin.' Which protein encodes this specific E3 ubiquitin ligase? | E3 ubiquitin-protein ligase UBR5 | Medium | convergence | {"qa_id":"medium_convergence_04918","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VIRMA and GSK3B share common interaction partners. One such shared partner is described in evidence stating: 'We show that GSK-3β directly interacts with the... | |
medium_convergence_04919 | CTNNB1 and DUSP4 share interaction partners. One such shared partner is implicated in a study proposing that a specific kinase binds to beta-catenin to regulate adherens junction formation and cell-to-cell adhesion. Which protein is encoded by this shared interaction partner? | Mitogen-activated protein kinase 8 | Medium | convergence | {"qa_id":"medium_convergence_04919","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and DUSP4 share interaction partners. One such shared partner is implicated in a study proposing that a specific kinase binds to beta-catenin to regul... | |
medium_convergence_04920 | POLR2E and POLR2G both interact with a shared protein. Evidence indicates that the interaction between this shared protein and RNA Polymerase II is direct and mediated by the RPB1 subunit. Which protein product is encoded by this shared protein? | ATP-dependent DNA helicase Q5 | Medium | convergence | {"qa_id":"medium_convergence_04920","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLR2E and POLR2G both interact with a shared protein. Evidence indicates that the interaction between this shared protein and RNA Polymerase II is direct an... | |
medium_convergence_04923 | EIF3B and EIF3J each share a binding partner. Experimental evidence indicates that one of these shared partners interacts directly with eIF3c, eIF3g, and eIF3j, as demonstrated by glutathione S-transferase pull-down assays. Which protein is encoded by this specific shared partner? | Eukaryotic translation initiation factor 3 subunit K | Medium | convergence | {"qa_id":"medium_convergence_04923","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3B and EIF3J each share a binding partner. Experimental evidence indicates that one of these shared partners interacts directly with eIF3c, eIF3g, and eIF... | |
medium_convergence_04924 | Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.195 and an adjusted p-value of 0.005947. Which protein is encoded by this gene? | SERTA domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04924","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) ... | |
medium_convergence_04925 | EEF1G and PRKN each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'This peptide was responsible for the specific interaction of CRS with elongation factor-1gamma.' Which protein encodes that specific shared entity? | Cysteine--tRNA ligase, cytoplasmic | Medium | convergence | {"qa_id":"medium_convergence_04925","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EEF1G and PRKN each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'This peptide was responsible for th... | |
medium_convergence_04926 | CCDC22 and CUL1 each interact with more than one shared protein. Evidence concerning one shared entity reports that it contains an F-box domain and is associated with the proteins Skp1, Roc-1, and Cullin-1, suggesting that it is a component of a SCF ubiquitination complex. Which disease is connected to that entity? | intellectual disability, autosomal recessive 45 | Medium | convergence | {"qa_id":"medium_convergence_04926","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCDC22 and CUL1 each interact with more than one shared protein. Evidence concerning one shared entity reports that it contains an F-box domain and is associ... | |
medium_convergence_04928 | EP300 and RBPJ share multiple interaction partners. One such partner is reported to colocalize in vivo and form a complex with the transcriptional coactivator p300. Which protein is encoded by this shared interaction partner? | DNA polymerase beta | Medium | convergence | {"qa_id":"medium_convergence_04928","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and RBPJ share multiple interaction partners. One such partner is reported to colocalize in vivo and form a complex with the transcriptional coactivato... | |
medium_convergence_04929 | HIST2H3A and MECP2 each share a binding partner. Evidence concerning one shared entity reports that methylated DNA assembled into chromatin binds the transcriptional repressor MECP2, which cofractionates with Sin3 and histone deacetylase. Which protein is connected to that entity through the 'encodes' relation? | Paired amphipathic helix protein Sin3a | Medium | convergence | {"qa_id":"medium_convergence_04929","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIST2H3A and MECP2 each share a binding partner. Evidence concerning one shared entity reports that methylated DNA assembled into chromatin binds the transcr... | |
medium_convergence_04930 | FCGR2B and HLA-G are both involved in more than one shared biological process. One such shared process is supported by evidence stating: 'The inhibitory receptor FcγRIIB plays a central role in regulating the generation of autoantibodies and their effector functions, which include activation of innate immune cells and ... | immune response | Medium | convergence | {"qa_id":"medium_convergence_04930","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FCGR2B and HLA-G are both involved in more than one shared biological process. One such shared process is supported by evidence stating: 'The inhibitory rece... | |
medium_convergence_04931 | RBCK1 and IKBKG both interact with a shared protein that is a component of the linear ubiquitin chain assembly complex (LUBAC) and participates in the ubiquitylation of NEMO. Which protein is encoded by the gene corresponding to this shared entity? | E3 ubiquitin-protein ligase RNF31 | Medium | convergence | {"qa_id":"medium_convergence_04931","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RBCK1 and IKBKG both interact with a shared protein that is a component of the linear ubiquitin chain assembly complex (LUBAC) and participates in the ubiqui... | |
medium_convergence_04932 | PEX13 and PEX26 both interact with a specific protein. Evidence indicates that this protein, along with Pex1 of the AAA ATPase family, co-immunoprecipitates with Pex26. Which protein is encoded by the gene corresponding to this interacting partner? | Peroxisomal ATPase PEX6 | Medium | convergence | {"qa_id":"medium_convergence_04932","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PEX13 and PEX26 both interact with a specific protein. Evidence indicates that this protein, along with Pex1 of the AAA ATPase family, co-immunoprecipitates ... | |
medium_convergence_04933 | ESR1 and ESR2 both interact with a specific protein subunit of the TRAP/Mediator complex. Evidence indicates that interactions involving this subunit depend on TRAP220, which has been shown to interact with estrogen receptors and other nuclear receptors in a ligand-dependent manner. Which protein is encoded by the gene... | Mediator of RNA polymerase II transcription subunit 24 | Medium | convergence | {"qa_id":"medium_convergence_04933","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and ESR2 both interact with a specific protein subunit of the TRAP/Mediator complex. Evidence indicates that interactions involving this subunit depend ... | |
medium_convergence_04934 | JAG1 and DLL4 both interact with a specific receptor protein. Experimental evidence indicates that while both manic fringe (mFng) and lunatic fringe (lFng) reduce the binding of Jagged1 to this receptor (but not the binding of Delta1), the inhibitory effect of mFng is stronger than that of lFng. Which protein is encode... | Neurogenic locus notch homolog protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04934","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"JAG1 and DLL4 both interact with a specific receptor protein. Experimental evidence indicates that while both manic fringe (mFng) and lunatic fringe (lFng) r... | |
medium_convergence_04935 | TNIP1 and EGFR share a common interacting partner. Evidence indicates that the endoplasmic reticulum-associated translocon Sec61β resides in the inner nuclear membrane and associates with this shared partner. Which protein is encoded by this shared partner? | Protein transport protein Sec61 subunit alpha isoform 1 | Medium | convergence | {"qa_id":"medium_convergence_04935","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TNIP1 and EGFR share a common interacting partner. Evidence indicates that the endoplasmic reticulum-associated translocon Sec61β resides in the inner nuclea... | |
medium_convergence_04936 | NUDT21 and PPP1CA both interact with a specific shared protein. Evidence indicates that ATR and CHK1 kinase inhibitors induce Ser2205 phosphorylation of this shared protein in a CDK1-dependent manner, an event that disrupts its interaction with PP1 phosphatase. Which protein is encoded by this shared entity? | Telomere-associated protein RIF1 | Medium | convergence | {"qa_id":"medium_convergence_04936","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUDT21 and PPP1CA both interact with a specific shared protein. Evidence indicates that ATR and CHK1 kinase inhibitors induce Ser2205 phosphorylation of this... | |
medium_convergence_04937 | E2F1 and AKT1 share a common interacting partner. Experimental evidence indicates that a deletion of the RING domain in this partner (creating a ΔRING variant) results in its nuclear localization and increased binding to E2F1. Conversely, deletion of the BIR (Baculoviral IAP Repeat) domains (creating a ΔBIRs variant) c... | E3 ubiquitin-protein ligase XIAP | Medium | convergence | {"qa_id":"medium_convergence_04937","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"E2F1 and AKT1 share a common interacting partner. Experimental evidence indicates that a deletion of the RING domain in this partner (creating a ΔRING varian... | |
medium_convergence_04939 | ARF4 and ASAP1 both interact with a common protein partner. Experimental evidence indicates that this shared partner directly binds to FIP3 via its BAR domain, as confirmed by coimmunoprecipitation and in vitro pulldown assays. Which gene encodes this shared protein partner? | Rab11 family-interacting protein 3 | Medium | convergence | {"qa_id":"medium_convergence_04939","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARF4 and ASAP1 both interact with a common protein partner. Experimental evidence indicates that this shared partner directly binds to FIP3 via its BAR domai... | |
medium_convergence_04940 | Both 'regulation of fatty acid metabolic process' and 'regulation of aldosterone metabolic process' are subtypes of a shared biological process. Evidence for one such shared entity states: 'Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.' Which biol... | small molecule metabolic process | Medium | convergence | {"qa_id":"medium_convergence_04940","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both 'regulation of fatty acid metabolic process' and 'regulation of aldosterone metabolic process' are subtypes of a shared biological process. Evidence for... | |
medium_convergence_04941 | KLF12 and ESR1 share multiple interacting partners. One such shared partner has been shown to interact with ERalpha in the presence of 17beta-estradiol, but not in the presence of tamoxifen or raloxifene, in a yeast two-hybrid system. Which protein is encoded by this shared interacting partner? | Four and a half LIM domains protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04941","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KLF12 and ESR1 share multiple interacting partners. One such shared partner has been shown to interact with ERalpha in the presence of 17beta-estradiol, but ... | |
medium_convergence_04942 | Vaccinia virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -2.276 and an adjusted p-value of 0.02327. Which disease is associated with this gene? | GM3 synthase deficiency | Medium | convergence | {"qa_id":"medium_convergence_04942","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) re... | |
medium_convergence_04943 | CHUK and CASP8 both interact with a shared protein. Evidence indicates that this shared protein is a serine-threonine kinase involved in the activation of the NF-kappaB pathway, specifically identified as a receptor-interacting protein kinase (alongside NIK, IKK1, and IKK2) in interactions with Caspase 8. Which protein... | Receptor-interacting serine/threonine-protein kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_04943","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and CASP8 both interact with a shared protein. Evidence indicates that this shared protein is a serine-threonine kinase involved in the activation of th... | |
medium_convergence_04944 | MDH2 and PRKN (PARK2) share common interaction partners. One such shared partner is described in evidence stating: 'Mechanistically, we found that MDHDH directly bound to MDH2 and [the shared entity] (20S proteasomal core subunit alpha-type 1) as a molecular scaffold and accelerated the degradation of MDH2 by promoting... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_04944","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDH2 and PRKN (PARK2) share common interaction partners. One such shared partner is described in evidence stating: 'Mechanistically, we found that MDHDH dire... | |
medium_convergence_04945 | ANAPC1 and CDC20 both interact with a shared protein complex component. Experimental evidence indicates that in extracts prepared from M phase, but not from interphase HeLa cells, p55CDC coimmunoprecipitates with three important elements of the M phase checkpoint machinery: the shared entity, Cdc16, and Mad2. Which gen... | CDH1 | Medium | convergence | {"qa_id":"medium_convergence_04945","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC1 and CDC20 both interact with a shared protein complex component. Experimental evidence indicates that in extracts prepared from M phase, but not from ... | |
medium_convergence_04946 | EZH2 and FGFR1 share multiple interacting partners. One such partner is identified by evidence stating: 'Co-immunoprecipitation studies revealed that a specific tyrosine kinase directly associated with FGFR-1beta.' Which protein is encoded by this specific interacting partner? | Tyrosine-protein kinase Yes | Medium | convergence | {"qa_id":"medium_convergence_04946","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EZH2 and FGFR1 share multiple interacting partners. One such partner is identified by evidence stating: 'Co-immunoprecipitation studies revealed that a speci... | |
medium_convergence_04948 | Both RRAS2 and HRAS interact with a specific shared gene product. Experimental evidence indicates that the protein encoded by a human cDNA (clone 99) interacts directly with yeast Ras2p and human H-Ras, and this gene was named based on its function in Ras interaction/interference. Which protein is encoded by this gene? | Ras and Rab interactor 1 | Medium | convergence | {"qa_id":"medium_convergence_04948","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both RRAS2 and HRAS interact with a specific shared gene product. Experimental evidence indicates that the protein encoded by a human cDNA (clone 99) interac... | |
medium_convergence_04949 | Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 4.24 and an adjusted p-value of approximately 0.0208. Which disease is associated with this gene through genomic alterations? | clear cell renal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04949","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a... | |
medium_convergence_04950 | CUL1 and BTRC each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Upon phosphorylation by IKK, the precursor protein of the shared entity attracts the SCF E3 ubiquitin ligase substrate recognition molecules betaTrCP1 and betaTrCP2, resulting in polyubiquitination and complet... | Nuclear factor NF-kappa-B p105 subunit | Medium | convergence | {"qa_id":"medium_convergence_04950","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CUL1 and BTRC each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Upon phosphorylation by IKK, the precursor pro... | |
medium_convergence_04951 | CSNK2B and MAPK3 share multiple interacting partners. One such partner is implicated in a study reporting that RSK1 and ERK1/2 form a complex in quiescent HEK293 cells that transiently dissociates upon mitogen stimulation. Which cell type is enriched for this specific shared partner? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_04951","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2B and MAPK3 share multiple interacting partners. One such partner is implicated in a study reporting that RSK1 and ERK1/2 form a complex in quiescent HE... | |
medium_convergence_04952 | COPS6 and COPS2 both interact with a shared protein. Evidence regarding this shared protein states: 'We demonstrated that the C-terminal half of the shared protein encompassing the PCI domain is responsible for interaction with CSN2, CSN3, and CSN4 subunits and is required for incorporation of the subunit into the comp... | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_04952","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS6 and COPS2 both interact with a shared protein. Evidence regarding this shared protein states: 'We demonstrated that the C-terminal half of the shared p... | |
medium_convergence_04953 | BRMS1 and HDAC1 both interact with a shared protein partner. Experimental evidence indicates that this specific partner interacts with retinoblastoma binding protein 1 and at least seven members of the mSin3 histone deacetylase (HDAC) complex in human breast and melanoma cell lines, as demonstrated by yeast two-hybrid ... | Histone deacetylase complex subunit SAP30 | Medium | convergence | {"qa_id":"medium_convergence_04953","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRMS1 and HDAC1 both interact with a shared protein partner. Experimental evidence indicates that this specific partner interacts with retinoblastoma binding... | |
medium_convergence_04955 | Human polyomavirus 1 and Zika virus both upregulate a specific gene. Experimental data from renal epithelial cells (study GSE135833) indicate that this gene exhibits a log2 fold change of approximately 1.399 and an adjusted p-value of 0.02003. Which protein does this gene product interact with? | BTRC | Medium | convergence | {"qa_id":"medium_convergence_04955","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Zika virus both upregulate a specific gene. Experimental data from renal epithelial cells (study GSE135833) indicate that this gene ... | |
medium_convergence_04956 | NRP1 and FARP2 both interact with a common protein. Evidence indicates that both the sema domain and the remainder of the ectodomain of this protein associate with NRP1 in a Sema3A-independent manner. What molecular function is enabled by this protein? | semaphorin receptor activity | Medium | convergence | {"qa_id":"medium_convergence_04956","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NRP1 and FARP2 both interact with a common protein. Evidence indicates that both the sema domain and the remainder of the ectodomain of this protein associat... | |
medium_convergence_04957 | SNW1 and MYC both interact with a common protein partner. Experimental evidence for this partner describes its interaction with MYC and notes that the loss of this partner leads to reduced K48-linked ubiquitination of MYC in cells. Which protein is encoded by this common partner? | E3 ubiquitin-protein ligase UBR5 | Medium | convergence | {"qa_id":"medium_convergence_04957","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SNW1 and MYC both interact with a common protein partner. Experimental evidence for this partner describes its interaction with MYC and notes that the loss o... | |
medium_convergence_04958 | ESR1 and HDAC10 both interact with a shared protein partner. Evidence regarding this partner states: 'A protein-protein interaction assay indicated that the full-length ER binds to [the shared partner] in vitro.' Which protein is encoded by the gene corresponding to this shared partner? | Nuclear receptor corepressor 2 | Medium | convergence | {"qa_id":"medium_convergence_04958","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HDAC10 both interact with a shared protein partner. Evidence regarding this partner states: 'A protein-protein interaction assay indicated that the ... | |
medium_convergence_04959 | NFKB2 and BTRC both interact with a shared protein. Evidence regarding this shared protein states: 'Intriguingly, the betaTrCP homodimer, but not the heterodimer, was selectively recruited to pIkappaBalpha induced by TNF-alpha.' Which disease is associated with this shared protein via a protective relationship? | nephritis | Medium | convergence | {"qa_id":"medium_convergence_04959","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NFKB2 and BTRC both interact with a shared protein. Evidence regarding this shared protein states: 'Intriguingly, the betaTrCP homodimer, but not the heterod... | |
medium_convergence_04960 | ESR2 and ESRRB share binding partners. One such shared partner is a prominent component of the thyroid hormone receptor-associated protein (TRAP)/Mediator coactivator complex, which interacts with ERalpha and ERbeta in both unfractionated nuclear extracts and purified form. Which disease is connected to this specific e... | streptococcal pneumonia | Medium | convergence | {"qa_id":"medium_convergence_04960","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR2 and ESRRB share binding partners. One such shared partner is a prominent component of the thyroid hormone receptor-associated protein (TRAP)/Mediator co... | |
medium_convergence_04961 | ALYREF and CHTOP each interact with more than one shared protein partner. Evidence concerning one specific shared partner states: 'Both proteins interact with the mRNA export factor Aly and both are able to rescue the loss of Sub2p (the yeast homolog of UAP56), indicating that both proteins have similar functions.' Whi... | psoriasis | Medium | convergence | {"qa_id":"medium_convergence_04961","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALYREF and CHTOP each interact with more than one shared protein partner. Evidence concerning one specific shared partner states: 'Both proteins interact wit... | |
medium_convergence_04962 | COG4 and CD59 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'Our results suggest that COG4 serves as a core component of the complex by interacting directly with COG1, COG2, COG5, and this shared entity.' Which protein is encoded by the gene corresponding to t... | Conserved oligomeric Golgi complex subunit 7 | Medium | convergence | {"qa_id":"medium_convergence_04962","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COG4 and CD59 each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'Our results suggest that COG4 serves... | |
medium_convergence_04963 | EP300 and MAML3 both interact with a common protein target. Experimental evidence indicates that protein-protein interaction assays demonstrated the association of Notch-1-IC and the CH3 region of p300. Which protein is encoded by this shared target? | Neurogenic locus notch homolog protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04963","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and MAML3 both interact with a common protein target. Experimental evidence indicates that protein-protein interaction assays demonstrated the associat... | |
medium_convergence_04964 | Cyclosporine and Glimepiride both interact with a specific shared drug. Clinical evidence regarding the combination of Glimepiride and this shared drug reports an odds ratio of 1.63 (95% CI: 1.29-2.06). Which disease is this shared drug indicated for? | inherited lipid metabolism disorder | Medium | convergence | {"qa_id":"medium_convergence_04964","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cyclosporine and Glimepiride both interact with a specific shared drug. Clinical evidence regarding the combination of Glimepiride and this shared drug repor... | |
medium_convergence_04965 | Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately -2.39 and an adjusted p-value of approximately 0.041. Which protein is encoded by this gene? | Interleukin-1 receptor type 2 | Medium | convergence | {"qa_id":"medium_convergence_04965","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475... | |
medium_convergence_04967 | Both ACTR3 and AMPH interact with a specific protein complex subunit. Evidence regarding one such shared partner states: 'The structure of a complex with an AP-2 binding segment from amphiphysin reveals a novel binding motif that we term FxDxF, which is engaged in an extended conformation by a unique surface of the pla... | AP-2 complex subunit alpha-1 | Medium | convergence | {"qa_id":"medium_convergence_04967","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ACTR3 and AMPH interact with a specific protein complex subunit. Evidence regarding one such shared partner states: 'The structure of a complex with an ... | |
medium_convergence_04968 | DCTN1 and COPZ2 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Phosphorylation also enhanced the specific binding of p150(Glued) to the tail domain of HsEg5 in vitro, indicating that the two proteins are able to interact directly.' Which protein is encoded ... | Kinesin-like protein KIF11 | Medium | convergence | {"qa_id":"medium_convergence_04968","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCTN1 and COPZ2 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Phosphorylation also enhanced t... | |
medium_convergence_04969 | DNMT1 and FOXO1 both interact with a common protein partner. Evidence regarding this partner states: 'The non-catalytic amino terminus of DNMT1 binds to [this partner] and a new protein, DMAP1 (for DNMT1 associated protein), and can mediate transcriptional repression.' Which protein is encoded by the gene corresponding... | Histone deacetylase 2 | Medium | convergence | {"qa_id":"medium_convergence_04969","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNMT1 and FOXO1 both interact with a common protein partner. Evidence regarding this partner states: 'The non-catalytic amino terminus of DNMT1 binds to [thi... | |
medium_convergence_04971 | BIRC3 and BCL10 both interact with a common protein. Evidence regarding this shared partner states: 'Here, we show that Bcl10 undergoes K63-linked polyubiquitination in response to T cell activation and subsequently binds the regulatory subunit of IKK.' Which protein is encoded by this shared partner? | NF-kappa-B essential modulator | Medium | convergence | {"qa_id":"medium_convergence_04971","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC3 and BCL10 both interact with a common protein. Evidence regarding this shared partner states: 'Here, we show that Bcl10 undergoes K63-linked polyubiqui... | |
medium_convergence_04972 | KDR and PIK3CA each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We previously demonstrated that a non sulfated analogue of heparin, phenylacetate carboxymethyl benzylamide dextran (NaPaC) inhibited angiogenesis. Here, we observed that NaPaC inhibited the VEGF165 binding t... | Vascular endothelial growth factor A, long form | Medium | convergence | {"qa_id":"medium_convergence_04972","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KDR and PIK3CA each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We previously demonstrated that a non sulfate... | |
medium_convergence_04973 | Rhinovirus A and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.446 and an adjusted p-value of 0.02885. Which protein does this gene product interact with? | SMARCA4 | Medium | convergence | {"qa_id":"medium_convergence_04973","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a l... | |
medium_convergence_04974 | DDB1 and KPNA2 share multiple interacting partners. One such shared partner is part of a multi-subunit cullin RING E3 ligase complex (VprBP/DDB1/Cul4A/Roc1) that associates with full-length versions of this partner through VprBP. Which disease is connected to this shared partner through genomic alterations? | Histiocytic medullary reticulosis | Medium | convergence | {"qa_id":"medium_convergence_04974","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDB1 and KPNA2 share multiple interacting partners. One such shared partner is part of a multi-subunit cullin RING E3 ligase complex (VprBP/DDB1/Cul4A/Roc1) ... |
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