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medium_convergence_04753 | CASC3 and KPNB1 both interact with a shared protein partner. Evidence regarding this partner states: 'The C terminus binds importin-beta through RanGTP.' Which protein is encoded by the gene corresponding to this shared partner? | Nuclear pore complex protein Nup50 | Medium | convergence | {"qa_id":"medium_convergence_04753","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CASC3 and KPNB1 both interact with a shared protein partner. Evidence regarding this partner states: 'The C terminus binds importin-beta through RanGTP.' Whi... | |
medium_convergence_04754 | ERCC1 and CUL4A both interact with a shared protein partner. Evidence indicates that for one of these shared partners, complex formation is established by a direct interaction between binding domains involving ERCC1 and the protein product of ERCC4. Which cell type is enriched in this specific shared partner? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_04754","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC1 and CUL4A both interact with a shared protein partner. Evidence indicates that for one of these shared partners, complex formation is established by a ... | |
medium_convergence_04755 | SNAP25 and NRXN1 share a common interaction partner. Evidence regarding this shared partner states: 'The synaptosome-associated protein of 25 kDa (SNAP-25) interacts with syntaxin 1 and vesicle-associated membrane protein 2 (VAMP2) to form a ternary soluble N-ethylmaleimide-sensitive fusion protein attachment protein r... | Syntaxin-1A | Medium | convergence | {"qa_id":"medium_convergence_04755","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SNAP25 and NRXN1 share a common interaction partner. Evidence regarding this shared partner states: 'The synaptosome-associated protein of 25 kDa (SNAP-25) i... | |
medium_convergence_04756 | CUL1 and BTRC each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Upon phosphorylation by IKK, the precursor protein of NF-κB1 attracts the SCF E3 ubiquitin ligase substrate recognition molecules betaTrCP1 and betaTrCP2, resulting in polyubiquitination and complete degradati... | kidney cancer | Medium | convergence | {"qa_id":"medium_convergence_04756","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CUL1 and BTRC each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Upon phosphorylation by IKK, the precursor pro... | |
medium_convergence_04757 | Vaccinia virus and Dengue virus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.94 and an adjusted p-value of approximately 0.0315. Which cell type is this gene enriched in? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_04757","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Dengue virus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) re... | |
medium_convergence_04758 | DBF4 and CDC6 both interact with a common protein partner. Experimental evidence indicates that this shared partner binds strongly to ORC1, itself, and MCM7 proteins. Which protein product is encoded by this shared partner? | Origin recognition complex subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_04758","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DBF4 and CDC6 both interact with a common protein partner. Experimental evidence indicates that this shared partner binds strongly to ORC1, itself, and MCM7 ... | |
medium_convergence_04759 | Acetohexamide and Betamethasone share a common interacting drug. Evidence regarding this shared entity states that combined treatment during pubertal and adult periods induces male-specific reductase activity in the liver microsomes of female rats. Which disease is this shared drug indicated for? | hypogonadotropic hypogonadism | Medium | convergence | {"qa_id":"medium_convergence_04759","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Acetohexamide and Betamethasone share a common interacting drug. Evidence regarding this shared entity states that combined treatment during pubertal and adu... | |
medium_convergence_04760 | FANCD2 and FAAP100 both interact with a specific protein. Evidence indicates that this protein forms a conserved DNA-remodeling complex with the histone-fold heterodimer MHF. Which protein is encoded by the gene corresponding to this interacting partner? | Fanconi anemia group M protein | Medium | convergence | {"qa_id":"medium_convergence_04760","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCD2 and FAAP100 both interact with a specific protein. Evidence indicates that this protein forms a conserved DNA-remodeling complex with the histone-fold... | |
medium_convergence_04762 | PHC1 and RING1 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'We have identified a new Zn finger protein, which interacts directly with both Ring1 proteins (Ring1A and Ring1B) and with M33, two mutually interacting sets of proteins of the mammalian Polycomb complex.... | RING1 and YY1-binding protein | Medium | convergence | {"qa_id":"medium_convergence_04762","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PHC1 and RING1 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'We have identified a new Zn finger protei... | |
medium_convergence_04763 | KMT2A and BTRC each interact with more than one shared gene product. Evidence concerning one shared entity reports that SUMO2 conjugation facilitated its interaction with β-TrCP, leading to its proteasomal degradation. Which cellular component is connected to that entity through the 'located in' relationship? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_04763","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KMT2A and BTRC each interact with more than one shared gene product. Evidence concerning one shared entity reports that SUMO2 conjugation facilitated its int... | |
medium_convergence_04764 | Enterovirus A and Rhinovirus A both downregulate a specific gene. Experimental data from a study on rhabdomyosarcoma cells (GSE103308) indicates that this gene has a log2 fold change of approximately -1.818 and an adjusted p-value of 0.01932. Which protein does this gene product interact with? | CDC42 | Medium | convergence | {"qa_id":"medium_convergence_04764","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Rhinovirus A both downregulate a specific gene. Experimental data from a study on rhabdomyosarcoma cells (GSE103308) indicates that this ge... | |
medium_convergence_04765 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data from a melanoma cell line (study GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.544 and an adjusted p-value of 1.514e-... | Zinc finger protein SNAI3 | Medium | convergence | {"qa_id":"medium_convergence_04765","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experiment... | |
medium_convergence_04766 | HCK and IL6 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Chemical shift mapping data with 15N-labeled [receptor domain] and unlabeled IL-6 coupled with recent structural data clearly reveal the epitope within the [receptor domain] responsible for mediating the... | Interleukin-6 receptor subunit alpha | Medium | convergence | {"qa_id":"medium_convergence_04766","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HCK and IL6 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Chemical shift mapping data with 15N-lab... | |
medium_convergence_04767 | GABRA1 and GABRB2 are both involved in multiple shared biological processes. One shared process is supported by evidence stating: 'A cDNA encoding the human gamma-aminobutyric acid (GABA)A receptor beta 2 subunit has been cloned and sequenced.' Which biological process is this shared entity a subclass of (is_a)? | cell-cell signaling | Medium | convergence | {"qa_id":"medium_convergence_04767","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GABRA1 and GABRB2 are both involved in multiple shared biological processes. One shared process is supported by evidence stating: 'A cDNA encoding the human ... | |
medium_convergence_04769 | MIB2 and BIRC2 both interact with a common protein partner. Biochemical and structural evidence indicates that the cIAP1 RING domain (encoded by BIRC2) interacts with a ubiquitin-conjugating enzyme E2-Ub complex, promoting a closed conformation that primes the thioester bond for ubiquitin transfer. Which protein, encod... | Ubiquitin-conjugating enzyme E2 D2 | Medium | convergence | {"qa_id":"medium_convergence_04769","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MIB2 and BIRC2 both interact with a common protein partner. Biochemical and structural evidence indicates that the cIAP1 RING domain (encoded by BIRC2) inter... | |
medium_convergence_04770 | STRA13 and FANCC each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The N terminus appears to stabilize the interaction with FANCA and FANCG and is essential for the binding of the FANCC/FANCE subcomplex.' Which disease is associated with that specific sha... | Fanconi anemia | Medium | convergence | {"qa_id":"medium_convergence_04770","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STRA13 and FANCC each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The N terminus appears to... | |
medium_convergence_04771 | Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Evidence for this gene in foreskin fibroblast cell lines (study GSE132081) reports a log2 fold change of approximately 1.227 and an adjusted p-value of 0.0009479. Which molecular function is enabled by this gene? | extracellular matrix structural constituent | Medium | convergence | {"qa_id":"medium_convergence_04771","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Evidence for this gene in foreskin fibroblast cell lines (study GSE132081) reports ... | |
medium_convergence_04772 | HSPA1A and HSP90AA1 both interact with a specific shared protein. Evidence indicates that this protein is part of a TCR-linked multiprotein complex containing HSP90 and FYN, and is essential for TCR-dependent activation of this protein and FYN. Which disease is associated with this protein as a biomarker? | familial glucocorticoid deficiency | Medium | convergence | {"qa_id":"medium_convergence_04772","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA1A and HSP90AA1 both interact with a specific shared protein. Evidence indicates that this protein is part of a TCR-linked multiprotein complex containin... | |
medium_convergence_04773 | Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line (study GSE111036) shows a log2 fold change of approximately 1.295 and an adjusted p-value of 0.04313. Which protein is encoded by this gene? | Spermatogenesis-associated protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04773","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a foreskin fibroblast cell line (study GSE111036... | |
medium_convergence_04774 | Hepacivirus C and Zaire ebolavirus both upregulate a specific gene. Evidence for this gene shows a log2 fold change of 1.155 and an adjusted p-value of 0.004336. Which cellular component is this gene located in? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_04774","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Zaire ebolavirus both upregulate a specific gene. Evidence for this gene shows a log2 fold change of 1.155 and an adjusted p-value of 0.004... | |
medium_convergence_04775 | The genes SLC29A4 and SLC22A1 both enable a specific molecular function. Evidence regarding this function highlights that the plasma membrane monoamine transporter (PMAT) and organic cation transporter 3 (OCT3) are the two most prominent low-affinity, high-capacity transporters for endogenous biogenic amines. Which bio... | monoamine transport | Medium | convergence | {"qa_id":"medium_convergence_04775","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The genes SLC29A4 and SLC22A1 both enable a specific molecular function. Evidence regarding this function highlights that the plasma membrane monoamine trans... | |
medium_convergence_04776 | CSTF2 and TSEN2 both interact with a shared protein complex component. Evidence regarding this component states: 'This enzyme consists of HsSen2, HsSen34, HsSen15, and HsSen54, homologs of the yeast tRNA endonuclease subunits.' Which protein is encoded by the gene corresponding to this specific component? | tRNA-splicing endonuclease subunit Sen54 | Medium | convergence | {"qa_id":"medium_convergence_04776","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSTF2 and TSEN2 both interact with a shared protein complex component. Evidence regarding this component states: 'This enzyme consists of HsSen2, HsSen34, Hs... | |
medium_convergence_04777 | SIRT1 and XRCC6 both interact with a specific shared protein. Evidence indicates that this shared protein associates with the MRN complex and maintains a component of this complex in a hypoacetylated state, a condition required for ionizing radiation-induced phosphorylation of that component at Ser343. Which protein is... | Nibrin | Medium | convergence | {"qa_id":"medium_convergence_04777","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIRT1 and XRCC6 both interact with a specific shared protein. Evidence indicates that this shared protein associates with the MRN complex and maintains a com... | |
medium_convergence_04778 | EP300 and ELOC both interact with a specific transcription factor. Evidence indicates that while CBP can bind to HIF-2α independent of its C-terminal activation domain, p300 only complexes with HIF-2α through this domain. Based on this evidence identifying the shared entity, which cellular component is this entity loca... | transcription regulator complex | Medium | convergence | {"qa_id":"medium_convergence_04778","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and ELOC both interact with a specific transcription factor. Evidence indicates that while CBP can bind to HIF-2α independent of its C-terminal activat... | |
medium_convergence_04779 | KAT5 and BRCA1 both interact with a common protein partner. Evidence indicates that BRCA1 interacts directly with this partner and stimulates its helicase and exonuclease activities in vitro. Which protein is encoded by this partner? | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | Medium | convergence | {"qa_id":"medium_convergence_04779","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and BRCA1 both interact with a common protein partner. Evidence indicates that BRCA1 interacts directly with this partner and stimulates its helicase an... | |
medium_convergence_04780 | YAP1 and YWHAQ share a common interaction partner. Evidence for one such partner indicates that it binds to YAP1 and mediates the ubiquitination and degradation of YAP1. Which protein is encoded by this interaction partner? | E3 ubiquitin-protein ligase NEDD4-like | Medium | convergence | {"qa_id":"medium_convergence_04780","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and YWHAQ share a common interaction partner. Evidence for one such partner indicates that it binds to YAP1 and mediates the ubiquitination and degradat... | |
medium_convergence_04781 | RPA1 and STX1A share multiple interacting partners. One such partner is described in the following evidence: 'Here we report the identification and characterization of a novel RING finger protein, [interacting partner], that interacts with syntaxin 1.' Which protein is encoded by this specific interacting partner? | E3 ubiquitin-protein ligase BRE1B | Medium | convergence | {"qa_id":"medium_convergence_04781","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPA1 and STX1A share multiple interacting partners. One such partner is described in the following evidence: 'Here we report the identification and character... | |
medium_convergence_04782 | RUVBL2 and MTOR share multiple interacting partners. One such partner is characterized by evidence stating: 'Quantitative immunoblotting showed that the abundance of this protein is low compared with the PIKKs, and it preferentially bound newly synthesized ATM, ATR, mTOR, and DNA-PKcs.' Which disease is associated with... | TELO2-related intellectual disability-neurodevelopmental disorder | Medium | convergence | {"qa_id":"medium_convergence_04782","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RUVBL2 and MTOR share multiple interacting partners. One such partner is characterized by evidence stating: 'Quantitative immunoblotting showed that the abun... | |
medium_convergence_04783 | CDH16 and CDH1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'However, UCS15A was unable to disrupt the non-SH3-mediated protein-protein interactions of beta-catenin, with E-cadherin and alpha-catenin.' Which protein is encoded by the gene correspondin... | Catenin alpha-1 | Medium | convergence | {"qa_id":"medium_convergence_04783","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDH16 and CDH1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'However, UCS15A was unable ... | |
medium_convergence_04784 | SYNCRIP and CHD3 both interact with a shared protein. Experimental evidence indicates that Ki-1/57 associates with endogenous splicing proteins hnRNPQ and SFRS9 in HeLa cell extracts. Which protein is encoded by the gene corresponding to this shared entity? | Intracellular hyaluronan-binding protein 4 | Medium | convergence | {"qa_id":"medium_convergence_04784","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SYNCRIP and CHD3 both interact with a shared protein. Experimental evidence indicates that Ki-1/57 associates with endogenous splicing proteins hnRNPQ and SF... | |
medium_convergence_04785 | ADRM1 and POMP both interact with a common protein. Evidence indicates that this protein interacts with proteassemblin and beta5, but not beta5i, suggesting a role in the propeptide-dependent differential incorporation of these subunits. Which disease is associated with this protein? | leukemia | Medium | convergence | {"qa_id":"medium_convergence_04785","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADRM1 and POMP both interact with a common protein. Evidence indicates that this protein interacts with proteassemblin and beta5, but not beta5i, suggesting ... | |
medium_convergence_04786 | Dengue virus and Enterovirus A both upregulate a specific gene. Evidence for this gene in a hepatoma cell line study (GSE110512) reports a log2 fold change of approximately 1.22 and an adjusted p-value of 0.0052. Which cell type is this gene enriched in? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_04786","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both upregulate a specific gene. Evidence for this gene in a hepatoma cell line study (GSE110512) reports a log2 fold change o... | |
medium_convergence_04787 | CHEK1 and VIRMA share multiple interacting partners. One such shared partner is identified in a study reporting the identification of the heterohexamic minichromosome maintenance (MCM) complex that interacts with Chk1 by mass spectrometry. Which protein is encoded by this shared interacting partner? | DNA replication licensing factor MCM6 | Medium | convergence | {"qa_id":"medium_convergence_04787","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and VIRMA share multiple interacting partners. One such shared partner is identified in a study reporting the identification of the heterohexamic minic... | |
medium_convergence_04788 | FYN and ARHGEF7 both interact with a specific shared protein. Evidence indicates that in the brain, Piccolo forms a complex with this shared protein along with various GIT-associated proteins, including betaPIX, focal adhesion kinase, liprin-alpha, and paxillin. Which protein is encoded by the gene corresponding to thi... | ARF GTPase-activating protein GIT1 | Medium | convergence | {"qa_id":"medium_convergence_04788","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FYN and ARHGEF7 both interact with a specific shared protein. Evidence indicates that in the brain, Piccolo forms a complex with this shared protein along wi... | |
medium_convergence_04789 | CDKN2A and ASXL1 share a common interacting partner. Evidence indicates that this shared partner is a component of the 19S regulatory subunit of the 26S proteasome, which specifically interacts with ARF. Which protein is encoded by this shared interacting partner? | 26S proteasome regulatory subunit 6A | Medium | convergence | {"qa_id":"medium_convergence_04789","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN2A and ASXL1 share a common interacting partner. Evidence indicates that this shared partner is a component of the 19S regulatory subunit of the 26S prot... | |
medium_convergence_04790 | PARP2 and PARP1 each interact with more than one shared gene product. Evidence concerning one shared entity reports that this shared gene product forms a robust protein complex with PARP-1 in cells and is recruited to DNA lesions in a PARP-1-dependent manner, but independently of PARP-1 catalytic ADP-ribosylation activ... | Histone PARylation factor 1 | Medium | convergence | {"qa_id":"medium_convergence_04790","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP2 and PARP1 each interact with more than one shared gene product. Evidence concerning one shared entity reports that this shared gene product forms a rob... | |
medium_convergence_04793 | Human alphaherpesvirus 1 and Rhinovirus A both upregulate a specific gene. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.405 and an adjusted p-value of approximately 0.005. Which disease is associated with this gene as a biomarker? | squamous cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04793","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Rhinovirus A both upregulate a specific gene. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports... | |
medium_convergence_04795 | GATA4 and ISL1 both physically interact with a specific transcription factor. Evidence regarding this interaction states: 'The synergy involves physical [entity]-GATA-4 interaction, seen in vitro and in vivo, which maps to the C-terminal zinc finger of GATA-4 and a C-terminus extension; similarly, a C-terminally extend... | myocardial ischemia | Medium | convergence | {"qa_id":"medium_convergence_04795","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GATA4 and ISL1 both physically interact with a specific transcription factor. Evidence regarding this interaction states: 'The synergy involves physical [ent... | |
medium_convergence_04796 | POMP and PSMB2 both interact with a common protein partner. Evidence indicates that proteassemblin interacts with beta5, but not beta5i, suggesting a role in the differential incorporation of these subunits. Which protein is encoded by the gene corresponding to this shared partner? | Proteasome subunit beta type-5 | Medium | convergence | {"qa_id":"medium_convergence_04796","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POMP and PSMB2 both interact with a common protein partner. Evidence indicates that proteassemblin interacts with beta5, but not beta5i, suggesting a role in... | |
medium_convergence_04797 | TRIM21 and UBC share multiple interacting partners. One such shared partner is supported by evidence stating: 'The mammalian 2-hybrid assay confirmed the interaction between full-length 52Ro and UnpEL.' Which disease is associated with this specific shared partner via a biomarker relationship? | male infertility | Medium | convergence | {"qa_id":"medium_convergence_04797","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM21 and UBC share multiple interacting partners. One such shared partner is supported by evidence stating: 'The mammalian 2-hybrid assay confirmed the int... | |
medium_convergence_04798 | Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of multiple shared genes. One such shared gene exhibits a log2 fold change of -1.171 and an adjusted p-value of 0.003886 in study GSE131840. What molecular function is enabled by this specific gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_04798","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of multiple shared genes. One such shared gene exhibits a log2 fold chang... | |
medium_convergence_04799 | GDF11 and INHBA both bind to a shared receptor. Evidence regarding one such shared receptor states: 'We hypothesized that, in addition to its canonical receptor [Type II activin receptor], activin A might similarly bind and signal via BMPR2.' Which disease is associated with this specific receptor through genomic alter... | malignant colon neoplasm | Medium | convergence | {"qa_id":"medium_convergence_04799","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GDF11 and INHBA both bind to a shared receptor. Evidence regarding one such shared receptor states: 'We hypothesized that, in addition to its canonical recep... | |
medium_convergence_04800 | RANBP9 and EGFR both interact with a shared protein. Evidence for one such interaction states: 'We have identified RanBPM as a novel interactor of the beta(2) integrin [shared protein] in a yeast-two-hybrid screen.' Which disease is therapeutically connected to this specific shared protein? | nephritis | Medium | convergence | {"qa_id":"medium_convergence_04800","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RANBP9 and EGFR both interact with a shared protein. Evidence for one such interaction states: 'We have identified RanBPM as a novel interactor of the beta(2... | |
medium_convergence_04802 | CIB1 and BIRC2 both interact with a specific shared protein. Experimental evidence indicates that this shared protein binds to a mitogen-activated protein kinase kinase kinase, interferes with the recruitment of TRAF2 to this kinase, and inhibits its autophosphorylation on threonine-838, thereby blocking its activation... | Mitogen-activated protein kinase kinase kinase 5 | Medium | convergence | {"qa_id":"medium_convergence_04802","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CIB1 and BIRC2 both interact with a specific shared protein. Experimental evidence indicates that this shared protein binds to a mitogen-activated protein ki... | |
medium_convergence_04803 | TCF3 and TCF12 both interact with a shared transcription factor. Evidence indicates that this shared factor binds the promoter of the melanoma metastasis-suppressing gene KiSS1 and enhances its expression through interaction with E12 (a TCF3 isoform) and TCF12. Which disease is associated with this shared factor via a ... | ovarian neoplasm | Medium | convergence | {"qa_id":"medium_convergence_04803","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TCF3 and TCF12 both interact with a shared transcription factor. Evidence indicates that this shared factor binds the promoter of the melanoma metastasis-sup... | |
medium_convergence_04804 | Hepacivirus C and Rhinovirus A both downregulate a specific gene. Experimental data for this gene shows a log2 fold change of -2.147 and an adjusted p-value of 0.003665. Which protein is encoded by this gene? | Nuclear protein 1 | Medium | convergence | {"qa_id":"medium_convergence_04804","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Rhinovirus A both downregulate a specific gene. Experimental data for this gene shows a log2 fold change of -2.147 and an adjusted p-value ... | |
medium_convergence_04805 | DNMT3B and ACTL6A both interact with a specific protein. Experimental evidence using immunoprecipitation and GST pull-down assays demonstrates that this protein interacts with HDAC1, HP1 proteins, Suv39h1, and the ATP-dependent chromatin remodeling enzyme hSNF2H. Which protein is encoded by the gene corresponding to th... | Histone deacetylase 2 | Medium | convergence | {"qa_id":"medium_convergence_04805","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNMT3B and ACTL6A both interact with a specific protein. Experimental evidence using immunoprecipitation and GST pull-down assays demonstrates that this prot... | |
medium_convergence_04806 | DDX3X and RPS6KB1 both interact with a shared protein entity. Evidence regarding this entity states: 'When inactive, S6K1 associates with the eIF3 complex, while the S6K1 activator mTOR/raptor does not.' Which disease is associated with this shared entity? | glioma | Medium | convergence | {"qa_id":"medium_convergence_04806","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDX3X and RPS6KB1 both interact with a shared protein entity. Evidence regarding this entity states: 'When inactive, S6K1 associates with the eIF3 complex, w... | |
medium_convergence_04807 | GABRA1 and GABRD are both involved in multiple shared biological processes. One of these shared processes is supported by evidence indicating that the associated entities facilitate spontaneous and action potential-driven postsynaptic GABAergic currents. What is the parent biological process (via an 'is_a' relationship... | chemical synaptic transmission | Medium | convergence | {"qa_id":"medium_convergence_04807","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GABRA1 and GABRD are both involved in multiple shared biological processes. One of these shared processes is supported by evidence indicating that the associ... | |
medium_convergence_04809 | TRIM28 and HSPA1A share multiple interacting partners. One such shared partner is implicated in a mechanism where acetylated Hsp70 recruits the E3 ligase KAP1, leading to Lys840 SUMOylation and increased activity of the phosphatidylinositol 3-kinase C3 bound to Beclin 1. Which disease is associated with this specific s... | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_04809","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and HSPA1A share multiple interacting partners. One such shared partner is implicated in a mechanism where acetylated Hsp70 recruits the E3 ligase KAP... | |
medium_convergence_04810 | RAD50 and RAD51 both interact with a common protein partner. Experimental evidence indicates that in assays using purified components, phosphorylation of RAD51 by c-Abl enhances the formation of a complex between RAD51 and this shared partner, which cooperates with RAD51 in recombination and repair. Which protein is en... | DNA repair protein RAD52 homolog | Medium | convergence | {"qa_id":"medium_convergence_04810","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD50 and RAD51 both interact with a common protein partner. Experimental evidence indicates that in assays using purified components, phosphorylation of RAD... | |
medium_convergence_04811 | CAND1 and CUL1 each interact with more than one shared protein. Evidence concerning one shared entity reports that it contains an F-box domain and is associated with the proteins Skp1, Roc-1, and Cullin-1, suggesting that it is a component of an SCF ubiquitination complex. Which protein is connected to that entity thro... | F-box only protein 31 | Medium | convergence | {"qa_id":"medium_convergence_04811","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAND1 and CUL1 each interact with more than one shared protein. Evidence concerning one shared entity reports that it contains an F-box domain and is associa... | |
medium_convergence_04812 | KDM1B and NCOR1 both interact with a specific nuclear receptor. Evidence indicates that LXRs interact with corepressors, including N-CoR, which are released upon binding agonists. Which protein is encoded by this shared nuclear receptor? | Oxysterols receptor LXR-beta | Medium | convergence | {"qa_id":"medium_convergence_04812","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KDM1B and NCOR1 both interact with a specific nuclear receptor. Evidence indicates that LXRs interact with corepressors, including N-CoR, which are released ... | |
medium_convergence_04813 | TGOLN2 and SEC61B both interact with a shared gene product. Evidence indicates that under physiological conditions, when TGN38 is not overexpressed, it interacts with integrin beta 1. Which cell type is enriched for this shared gene product? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_04813","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TGOLN2 and SEC61B both interact with a shared gene product. Evidence indicates that under physiological conditions, when TGN38 is not overexpressed, it inter... | |
medium_convergence_04814 | CDKN1A and AGR2 share common interacting partners. One such shared partner is a gene whose knockdown (specifically via MSX2 knockdown effects) suppresses the transcription of NOP2/Sun domain family member 2. This entity regulates p21 expression by binding to and causing 5-methylcytidine methylation of the 3'-untranslat... | RNA cytosine C(5)-methyltransferase NSUN2 | Medium | convergence | {"qa_id":"medium_convergence_04814","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN1A and AGR2 share common interacting partners. One such shared partner is a gene whose knockdown (specifically via MSX2 knockdown effects) suppresses the... | |
medium_convergence_04815 | The biological processes 'positive regulation of gamma-aminobutyric acid secretion' and 'positive regulation of glycine secretion, neurotransmission' share a common parent process. Evidence regarding one of the shared entities states: 'Any process that activates or increases the frequency, rate or extent of the regulat... | amino acid transport | Medium | convergence | {"qa_id":"medium_convergence_04815","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'positive regulation of gamma-aminobutyric acid secretion' and 'positive regulation of glycine secretion, neurotransmission' share a... | |
medium_convergence_04816 | Both IL12B and IL18 are involved in more than one shared biological process. One such shared process is linked to evidence stating that IL-23, together with IL-18, induced the proliferation of NK and NK-like T cells. Which biological process is positively regulated by this shared entity? | NK T cell proliferation | Medium | convergence | {"qa_id":"medium_convergence_04816","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IL12B and IL18 are involved in more than one shared biological process. One such shared process is linked to evidence stating that IL-23, together with ... | |
medium_convergence_04818 | EXOSC6 and NCBP1 share multiple binding partners. One of these shared partners is a protein that binds the cap-binding complex (CBC), which is universally present on capped RNAs, and also associates with the nuclear exosome targeting (NEXT) complex, thereby linking to RNA decay. Which biological process is this specifi... | RNA destabilization | Medium | convergence | {"qa_id":"medium_convergence_04818","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EXOSC6 and NCBP1 share multiple binding partners. One of these shared partners is a protein that binds the cap-binding complex (CBC), which is universally pr... | |
medium_convergence_04819 | DBNL and ITK each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Third, the Itk Src homology (SH3) 3 and SH2 domains interact cooperatively with Syk-phosphorylated [shared protein encoded by LCP2].' Which protein is connected to that entity through the 'encodes' relation? | Lymphocyte cytosolic protein 2 | Medium | convergence | {"qa_id":"medium_convergence_04819","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DBNL and ITK each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Third, the Itk Src homology (SH3) 3 and SH2 dom... | |
medium_convergence_04820 | EP300 and EZH2 both interact with a shared gene product. Evidence indicates that complexes containing p300 (but not CBP) and the nuclear proto-oncoprotein encoded by this shared gene product were detected in confluent cultures of G1-arrested cells, but not in sparse cells or during S or G2 phases. Which protein is enco... | Protein SSXT | Medium | convergence | {"qa_id":"medium_convergence_04820","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and EZH2 both interact with a shared gene product. Evidence indicates that complexes containing p300 (but not CBP) and the nuclear proto-oncoprotein en... | |
medium_convergence_04821 | GTF2B and CCNK both interact with a shared protein entity. Evidence regarding this entity states: 'Analyses of the binding of this motif to other general transcription factors showed that the former class was defective in binding to the basic helix-loop-helix motif of TFIIEβ and the latter class was defective in bindin... | General transcription factor IIE subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_04821","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2B and CCNK both interact with a shared protein entity. Evidence regarding this entity states: 'Analyses of the binding of this motif to other general tra... | |
medium_convergence_04822 | ERBB4 and JAK2 share multiple binding partners. One such partner is described in evidence stating: 'Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and the ErbB4-receptor tyrosine kinases.' Which disease is associated with this specific shared binding partner? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04822","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB4 and JAK2 share multiple binding partners. One such partner is described in evidence stating: 'Like NRG-1, the EGF-like domain of the new ligands binds ... | |
medium_convergence_04823 | RSPO4 and RSPO3 both interact with a specific receptor protein. Experimental evidence from a time-resolved fluorescence resonance energy transfer (TR-FRET) assay indicates that RSPOs bind to the LRR1-14 domain of this receptor with nanomolar affinities, following the rank order: RSPO4 > RSPO2 > RSPO3 > RSPO1. Which gen... | Leucine-rich repeat-containing G-protein coupled receptor 4 | Medium | convergence | {"qa_id":"medium_convergence_04823","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RSPO4 and RSPO3 both interact with a specific receptor protein. Experimental evidence from a time-resolved fluorescence resonance energy transfer (TR-FRET) a... | |
medium_convergence_04824 | AKT1 and PRKN each interact with more than one shared gene. Evidence concerning one shared entity reports: 'We found that the C-terminal region of protein kinase C-related kinase 2, containing amino acids 862 to 908, specifically binds to Akt in yeast and mammalian cells.' Which cell type is that entity enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_04824","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and PRKN each interact with more than one shared gene. Evidence concerning one shared entity reports: 'We found that the C-terminal region of protein ki... | |
medium_convergence_04825 | EIF1AX and EIF3H each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which protein is connected to that specific entity through the 'encodes' relationship? | Eukaryotic translation initiation factor 3 subunit M | Medium | convergence | {"qa_id":"medium_convergence_04825","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF1AX and EIF3H each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Indeed, CIF-1 binds eIF-3.F and... | |
medium_convergence_04826 | PARP1 and DDB2 both interact with a common protein partner. Experimental evidence indicates that PARP-1 and this shared partner co-immunoprecipitate from both soluble and DNA-bound fractions of S-phase-synchronized HeLa cells. Which protein is encoded by the gene corresponding to this shared partner? | DNA sliding clamp PCNA | Medium | convergence | {"qa_id":"medium_convergence_04826","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and DDB2 both interact with a common protein partner. Experimental evidence indicates that PARP-1 and this shared partner co-immunoprecipitate from bot... | |
medium_convergence_04828 | DVL1 and AXIN1 both interact with a common protein. Evidence regarding this shared partner states: 'We found that Axin interacts with beta-catenin and [the shared partner].' Which disease is associated with this specific shared protein? | telangiectasis | Medium | convergence | {"qa_id":"medium_convergence_04828","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DVL1 and AXIN1 both interact with a common protein. Evidence regarding this shared partner states: 'We found that Axin interacts with beta-catenin and [the s... | |
medium_convergence_04829 | KPNB1 and EIF4A3 both interact with a specific nucleoporin. Experimental evidence using a phage display system identified a short region within the N-terminus of this nucleoporin that binds to transportin 1 (TRN1), the import receptor for shuttling hnRNP proteins with an M9 nuclear localization sequence. Which protein ... | Nuclear pore complex protein Nup153 | Medium | convergence | {"qa_id":"medium_convergence_04829","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KPNB1 and EIF4A3 both interact with a specific nucleoporin. Experimental evidence using a phage display system identified a short region within the N-terminu... | |
medium_convergence_04830 | GAPDH and HMGA1 share a common interaction partner. Evidence indicates that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) interacts in vitro and in vivo with this specific protein. Which disease is associated with this shared interaction partner via a biomarker relationship? | triploidy | Medium | convergence | {"qa_id":"medium_convergence_04830","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GAPDH and HMGA1 share a common interaction partner. Evidence indicates that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) interacts in vitro and in vivo w... | |
medium_convergence_04831 | OCLN and RHOB share a common interaction partner. Evidence indicates that this shared entity interacts with the transmembrane protein occludin, the tight junction-specific MAGUK ZO-2, and F-actin, although the functional significance of these interactions is poorly understood. Which gene is connected to this shared ent... | WWTR1 | Medium | convergence | {"qa_id":"medium_convergence_04831","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OCLN and RHOB share a common interaction partner. Evidence indicates that this shared entity interacts with the transmembrane protein occludin, the tight jun... | |
medium_convergence_04832 | BRD4 and PRKDC share multiple interacting partners. One such shared partner is associated with a histone acetyltransferase, which has been found to interact with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a key component of nonhomologous end-joining (NHEJ) repair. Which protein is encoded by this sh... | Histone acetyltransferase KAT8 | Medium | convergence | {"qa_id":"medium_convergence_04832","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and PRKDC share multiple interacting partners. One such shared partner is associated with a histone acetyltransferase, which has been found to interact ... | |
medium_convergence_04834 | HBEGF and NRG2 both bind to a shared receptor tyrosine kinase. Evidence indicates that, similar to NRG-1, the EGF-like domain of these ligands binds to both ErbB3 and this specific receptor. Which protein is encoded by the gene corresponding to this receptor? | Receptor tyrosine-protein kinase erbB-4 | Medium | convergence | {"qa_id":"medium_convergence_04834","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HBEGF and NRG2 both bind to a shared receptor tyrosine kinase. Evidence indicates that, similar to NRG-1, the EGF-like domain of these ligands binds to both ... | |
medium_convergence_04835 | CORO1C and PRKN share interactions with multiple common partners. One such shared partner is involved in a complex with CORO1C and Rac1 that focuses active Rac1 to a single protrusion. Which protein is encoded by this shared partner? | Protein RCC2 | Medium | convergence | {"qa_id":"medium_convergence_04835","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CORO1C and PRKN share interactions with multiple common partners. One such shared partner is involved in a complex with CORO1C and Rac1 that focuses active R... | |
medium_convergence_04836 | AP2B1 and CNOT1 both interact with a shared protein. Evidence regarding this shared protein states: 'We found that human GW182 proteins recruit the PAN2-PAN3 and CCR4-CAF1-NOT deadenylase complexes through direct interactions with PAN3 and NOT1, respectively.' Which cell type is this shared protein enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_04836","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP2B1 and CNOT1 both interact with a shared protein. Evidence regarding this shared protein states: 'We found that human GW182 proteins recruit the PAN2-PAN3... | |
medium_convergence_04838 | CBX3 and HMGB1 share common interaction partners. One such shared partner is described by the following evidence: 'Here, we show that this protein binds to members of the heterochromatin protein 1 (HP1) families of non-histone chromosomal proteins.' Which protein is encoded by this shared interaction partner? | Nuclear autoantigen Sp-100 | Medium | convergence | {"qa_id":"medium_convergence_04838","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and HMGB1 share common interaction partners. One such shared partner is described by the following evidence: 'Here, we show that this protein binds to m... | |
medium_convergence_04839 | Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) shows a log2 fold change of approximately 1.103 and an adjusted p-value of 0.01995. Which protein is encoded by this gene? | Beta-enolase | Medium | convergence | {"qa_id":"medium_convergence_04839","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) shows a log2 f... | |
medium_convergence_04840 | Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) show a log2 fold change of -1.382 and an adjusted p-value of 0.0002456. Which protein is encoded by this gene? | Leucine-rich repeat transmembrane protein FLRT3 | Medium | convergence | {"qa_id":"medium_convergence_04840","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data for this gene in pleural mesothelio... | |
medium_convergence_04841 | Human alphaherpesvirus 3 and Primate bocaparvovirus 1 are both reported to downregulate a specific gene. Evidence for one such shared target indicates a log2 fold change of -1.017 and an adjusted p-value of 4.117e-06. Which disease is associated with this gene as a biomarker? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04841","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Primate bocaparvovirus 1 are both reported to downregulate a specific gene. Evidence for one such shared target indicates a log2... | |
medium_convergence_04842 | AREG and CBL each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we demonstrate that this entity associates directly with c-Cbl, a known down-regulator of RTK signaling.' Which disease is connected to that entity through a biomarker relationship? | intrahepatic cholangiocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_04842","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AREG and CBL each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we demonstrate that this entity associate... | |
medium_convergence_04843 | Codeine and Cetirizine both interact with a specific benzodiazepine. Evidence indicates that pretreatment with this entity, along with diazepam and clonazepam, inhibited the hypermotility produced by morphine and fentanyl. Which disease is this entity indicated for? | anxiety | Medium | convergence | {"qa_id":"medium_convergence_04843","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Codeine and Cetirizine both interact with a specific benzodiazepine. Evidence indicates that pretreatment with this entity, along with diazepam and clonazepa... | |
medium_convergence_04844 | CTNNB1 and PLK1 share multiple interacting partners. One such shared partner is identified in the following evidence: 'We identified beta-catenin, a component of adherens junctions, as a substrate of a protein tyrosine phosphatase by a 'substrate trapping' approach and by in vitro dephosphorylation with recombinant pro... | lymphedema-posterior choanal atresia syndrome | Medium | convergence | {"qa_id":"medium_convergence_04844","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and PLK1 share multiple interacting partners. One such shared partner is identified in the following evidence: 'We identified beta-catenin, a componen... | |
medium_convergence_04845 | CDK5 and HIST1H1A share multiple interacting partners. One such shared partner is supported by evidence stating: 'In two independent yeast transformation events, a cyclin D family member interacted with cdk-5.' Which protein is encoded by this shared interacting partner? | G1/S-specific cyclin-D2 | Medium | convergence | {"qa_id":"medium_convergence_04845","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK5 and HIST1H1A share multiple interacting partners. One such shared partner is supported by evidence stating: 'In two independent yeast transformation eve... | |
medium_convergence_04846 | Both Human alphaherpesvirus 1 and Dengue virus are reported to downregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), this gene exhibited a log2 fold change of -1.088 and an adjusted p-value of 0.0144. Which protein is encoded by this gene? | Cbp/p300-interacting transactivator 2 | Medium | convergence | {"qa_id":"medium_convergence_04846","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Dengue virus are reported to downregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), thi... | |
medium_convergence_04847 | FGFR1 and PRMT1 share multiple interacting partners. One such partner is distinguished by evidence stating: 'Mass spectrometry analysis identified that this protein was methylated at the arginine site and interacted with protein arginine methyltransferase 1.' Which protein is encoded by this specific shared partner? | Plakophilin-2 | Medium | convergence | {"qa_id":"medium_convergence_04847","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGFR1 and PRMT1 share multiple interacting partners. One such partner is distinguished by evidence stating: 'Mass spectrometry analysis identified that this ... | |
medium_convergence_04848 | YAP1 and CTNNA1 share multiple interacting partners. One such partner is described by the following evidence: Mechanically, this entity binds to Yes-associated protein 1 (YAP1), influencing its stability; silencing this entity inhibits YAP1 expression by promoting its ubiquitination and degradation in cardiac fibroblas... | depressive disorder | Medium | convergence | {"qa_id":"medium_convergence_04848","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and CTNNA1 share multiple interacting partners. One such partner is described by the following evidence: Mechanically, this entity binds to Yes-associat... | |
medium_convergence_04849 | Both Human mastadenovirus C and Primate bocaparvovirus 1 are associated with the downregulation of a specific gene. Experimental data for this gene in lung fibroblast cell lines (study GSE120891) reports a log2 fold change of approximately -1.303 and an adjusted p-value of 0.03813. Which protein is encoded by this gene... | Chromobox protein homolog 5 | Medium | convergence | {"qa_id":"medium_convergence_04849","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Primate bocaparvovirus 1 are associated with the downregulation of a specific gene. Experimental data for this gene in lung f... | |
medium_convergence_04850 | STAMBP and CHMP4B both interact with a shared protein. Evidence indicates that AMSH, an endosomal deubiquitinating enzyme, interacts with ESCRT-III subunits including CHMP1A, the shared protein, CHMP2A, and CHMP3. Which protein is encoded by this shared entity? | Charged multivesicular body protein 1b | Medium | convergence | {"qa_id":"medium_convergence_04850","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STAMBP and CHMP4B both interact with a shared protein. Evidence indicates that AMSH, an endosomal deubiquitinating enzyme, interacts with ESCRT-III subunits ... | |
medium_convergence_04851 | C17orf96 and EZH1 share interaction partners. One such shared partner is described in evidence stating: 'We have identified EZH1, a homolog of EZH2 that is physically present in a noncanonical PRC2 complex, as an H3K27 methyltransferase in vivo and in vitro.' Which protein is encoded by this shared entity? | Polycomb protein SUZ12 | Medium | convergence | {"qa_id":"medium_convergence_04851","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"C17orf96 and EZH1 share interaction partners. One such shared partner is described in evidence stating: 'We have identified EZH1, a homolog of EZH2 that is p... | |
medium_convergence_04852 | Enoxaparin and Edoxaban both interact with a specific shared entity. Clinical evidence indicates that this entity, identified as a specific polysaccharide solution, when combined with Enoxaparin, significantly increased early graft patency (p < 0.05) and reduced thrombus weights (p < 0.05) in grafts with restricted blo... | xerophthalmia | Medium | convergence | {"qa_id":"medium_convergence_04852","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enoxaparin and Edoxaban both interact with a specific shared entity. Clinical evidence indicates that this entity, identified as a specific polysaccharide so... | |
medium_convergence_04853 | EPS8 and FGFR1 share a common interacting partner. Experimental evidence indicates that an in vivo association between this shared entity and the SH3 domain protein v-Src was detected by coimmunoprecipitation. Which disease is associated with this shared entity? | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_04853","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPS8 and FGFR1 share a common interacting partner. Experimental evidence indicates that an in vivo association between this shared entity and the SH3 domain ... | |
medium_convergence_04854 | EPS15 and EPN1 both interact with a shared protein partner. Experimental evidence indicates that the UIM-containing endocytic adaptors EPS15 and Epsin exhibit preferential binding to a specific ubiquitin-like protein over its paralog. Based on this evidence, which protein is the shared partner, and what protein product... | Ubiquilin-2 | Medium | convergence | {"qa_id":"medium_convergence_04854","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPS15 and EPN1 both interact with a shared protein partner. Experimental evidence indicates that the UIM-containing endocytic adaptors EPS15 and Epsin exhibi... | |
medium_convergence_04855 | ACTR1A and COPA each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Affinity chromatography experiments demonstrate that the protein encoded by this shared partner binds directly to the Arp1 subunit of dynactin.' Which protein is encoded by the gene correspondin... | Dynactin subunit 4 | Medium | convergence | {"qa_id":"medium_convergence_04855","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR1A and COPA each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Affinity chromatography experim... | |
medium_convergence_04856 | Human polyomavirus 1 and Measles morbillivirus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 1.026 and an adjusted p-value of 0.04747. Which protein is encoded by this gene? | Interleukin enhancer-binding factor 3 | Medium | convergence | {"qa_id":"medium_convergence_04856","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Measles morbillivirus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) r... | |
medium_convergence_04857 | CTNNB1 and PML both interact with a specific shared protein. Evidence regarding this shared entity states: 'In vivo, beta-catenin interacts with the protein encoded by this gene in the absence of ligand, but agonists of this receptor enhanced the interaction.' Which protein is encoded by the gene corresponding to this ... | Retinoic acid receptor RXR-alpha | Medium | convergence | {"qa_id":"medium_convergence_04857","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and PML both interact with a specific shared protein. Evidence regarding this shared entity states: 'In vivo, beta-catenin interacts with the protein ... | |
medium_convergence_04858 | CHMP4B and MVB12B both interact with a specific protein. Experimental evidence indicates that in a yeast two-hybrid assay, HD-PTP showed positive interactions with this protein (also known as Shax1), endophilin A1, and ALG-2, but not with RabGAPLP or CIN85. Which protein is encoded by the gene corresponding to this int... | Programmed cell death 6-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_04858","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP4B and MVB12B both interact with a specific protein. Experimental evidence indicates that in a yeast two-hybrid assay, HD-PTP showed positive interaction... | |
medium_convergence_04859 | CBX1 and CABIN1 both interact with a shared protein entity. Evidence indicates that this entity's proteins associate with M31, which is currently the only other characterized mammalian SU(VAR) homologue. Which protein is encoded by this shared entity? | Histone-lysine N-methyltransferase SUV39H1 | Medium | convergence | {"qa_id":"medium_convergence_04859","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX1 and CABIN1 both interact with a shared protein entity. Evidence indicates that this entity's proteins associate with M31, which is currently the only ot... | |
medium_convergence_04860 | PPP2R1A and PPP2R1B both interact with a specific regulatory subunit of protein phosphatase 2A. Evidence indicates that this subunit, along with B56beta and B56epsilon, complexes with the PP2A A and C subunits and localizes to the cytoplasm, whereas other isoforms like B56delta are concentrated in the nucleus. Which ge... | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | Medium | convergence | {"qa_id":"medium_convergence_04860","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP2R1A and PPP2R1B both interact with a specific regulatory subunit of protein phosphatase 2A. Evidence indicates that this subunit, along with B56beta and ... | |
medium_convergence_04861 | CREBBP and HNRNPL share common interacting partners. One such shared partner is characterized by experimental evidence stating: 'In vitro glutathione S-transferase (GST) pull-down assay revealed that this protein strongly interacts with activating signal cointegrator (ASC)-2 and weakly with cyclic adenosine monophospha... | ovarian cancer | Medium | convergence | {"qa_id":"medium_convergence_04861","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and HNRNPL share common interacting partners. One such shared partner is characterized by experimental evidence stating: 'In vitro glutathione S-trans... | |
medium_convergence_04862 | ERBB3 and JAK2 share a common binding partner. Evidence regarding this shared entity states: 'Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases.' Which protein is encoded by this shared entity? | Pro-neuregulin-2, membrane-bound isoform | Medium | convergence | {"qa_id":"medium_convergence_04862","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB3 and JAK2 share a common binding partner. Evidence regarding this shared entity states: 'Like NRG-1, the EGF-like domain of the new ligands binds to bot... | |
medium_convergence_04863 | Dapsone and Lidocaine both interact with a specific drug. Clinical evidence regarding this drug states: 'Most patients resumed potentially interacting medications on the first day of nirmatrelvir-[this drug] withdrawal, and those drugs with DDI risk at the avoidance level mainly included dexamethasone and rivaroxaban, ... | HIV infectious disease | Medium | convergence | {"qa_id":"medium_convergence_04863","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dapsone and Lidocaine both interact with a specific drug. Clinical evidence regarding this drug states: 'Most patients resumed potentially interacting medica... |
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