qa_id stringlengths 24 32 | question stringlengths 156 1.14k | answer stringlengths 3 134 | level stringclasses 1
value | subtype stringclasses 3
values | source_medium_qa_id stringclasses 1
value | record_json stringlengths 13.6k 214k |
|---|---|---|---|---|---|---|
medium_convergence_04975 | IKBKB and RNF31 both physically interact with a specific shared protein. This protein is a core subunit of the Linear Ubiquitin Chain Assembly Complex (LUBAC), which is defined as containing this protein, HOIL-1L, and HOIP (also known as RNF31). Which gene product interacts with this shared LUBAC subunit? | UBL4A | Medium | convergence | {"qa_id":"medium_convergence_04975","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IKBKB and RNF31 both physically interact with a specific shared protein. This protein is a core subunit of the Linear Ubiquitin Chain Assembly Complex (LUBAC... | |
medium_convergence_04976 | PABPC1 and UPF1 share a common interacting partner. Evidence indicates that this shared partner, along with PABPC3 and PABPC4, acts as a substrate for a specific protein. Deletion or loss-of-function mutations in this specific protein are genetically associated with human central precocious puberty (CPP). Which disease... | idiopathic central precocious puberty | Medium | convergence | {"qa_id":"medium_convergence_04976","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PABPC1 and UPF1 share a common interacting partner. Evidence indicates that this shared partner, along with PABPC3 and PABPC4, acts as a substrate for a spec... | |
medium_convergence_04977 | FAAP20 and CENPS each interact with more than one shared gene. One of these shared entities is a Fanconi anemia protein that associates with the histone-fold complex MHF to form a branched DNA remodeling complex, which senses and repairs stalled replication forks and activates the FA DNA damage response network. Which ... | TELO2 | Medium | convergence | {"qa_id":"medium_convergence_04977","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAAP20 and CENPS each interact with more than one shared gene. One of these shared entities is a Fanconi anemia protein that associates with the histone-fold... | |
medium_convergence_04980 | ERG and HDAC1 share common interaction partners. One such shared partner is supported by evidence stating that Coimmunoprecipitation experiments indicate this entity and HDAC2 are associated with Topo II in vivo under normal physiological conditions. Which protein is encoded by this shared interaction partner? | DNA topoisomerase 2-beta | Medium | convergence | {"qa_id":"medium_convergence_04980","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERG and HDAC1 share common interaction partners. One such shared partner is supported by evidence stating that Coimmunoprecipitation experiments indicate thi... | |
medium_convergence_04981 | GNB1 and GNB2 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'The gamma 10 is modified by a geranylgeranyl group and is capable of interacting with beta 1 and beta 2 but not with beta 3.' Which protein is encoded by the gene corresponding to that entity? | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | Medium | convergence | {"qa_id":"medium_convergence_04981","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNB1 and GNB2 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'The gamma 10 is modified by a gera... | |
medium_convergence_04982 | Both Orthohepevirus A and Human gammaherpesvirus 8 are known to downregulate a specific gene. In a study of hepatocytes (GSE135619), this gene exhibited a log2 fold change of approximately -1.648 and an adjusted p-value of 0.04032. Which protein does this gene interact with? | SLC7A1 | Medium | convergence | {"qa_id":"medium_convergence_04982","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Human gammaherpesvirus 8 are known to downregulate a specific gene. In a study of hepatocytes (GSE135619), this gene exhibited a lo... | |
medium_convergence_04983 | MAPK14 and CSNK2B share multiple interaction partners. One such partner is described in evidence stating: 'A novel ribosomal S6 kinase (RSK) family member, a specific RSK isoform, was identified in a p38alphaMAPK-baited intracellular interaction screen.' Which gene is bound by this specific shared partner? | SH3GL2 | Medium | convergence | {"qa_id":"medium_convergence_04983","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK14 and CSNK2B share multiple interaction partners. One such partner is described in evidence stating: 'A novel ribosomal S6 kinase (RSK) family member, a... | |
medium_convergence_04984 | CDC7 and GINS1 both interact with a common protein substrate. Experimental evidence indicates that after reoxygenation, this specific shared entity undergoes significant phosphorylation and shows increased coimmunoprecipitation with CDC7. Which gene encodes this phosphorylated protein? | DNA replication licensing factor MCM2 | Medium | convergence | {"qa_id":"medium_convergence_04984","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC7 and GINS1 both interact with a common protein substrate. Experimental evidence indicates that after reoxygenation, this specific shared entity undergoes... | |
medium_convergence_04985 | LEF1 and DPF1 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'Here we show the interaction between the basic helix-loop-helix and leucine-zipper region of [the shared transcription factor] and LEF-1.' Which disease is connected to that entity through a causal relationship? | megacolon | Medium | convergence | {"qa_id":"medium_convergence_04985","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LEF1 and DPF1 each interact with more than one shared gene. Evidence concerning one shared entity reports: 'Here we show the interaction between the basic he... | |
medium_convergence_04987 | EP300 and NFIX both interact with a shared protein. Evidence concerning this shared entity states: 'Furthermore, we provide evidence supporting the formation of a complex between both factors in vivo and in vitro.' Which protein is encoded by this shared entity? | Paired box protein Pax-8 | Medium | convergence | {"qa_id":"medium_convergence_04987","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and NFIX both interact with a shared protein. Evidence concerning this shared entity states: 'Furthermore, we provide evidence supporting the formation... | |
medium_convergence_04988 | Propranolol and Labetalol both interact with a specific agent. Evidence indicates that pretreatment with Propranolol significantly shifted the dose-response curve of this agent to the left. Specifically, the agent (0.3 mg/ml) increased pulmonary resistance by 7.9 +/- 0.97 cmH2O.l-1.s-1 (mean +/- SEM of seven dogs) afte... | Amifampridine | Medium | convergence | {"qa_id":"medium_convergence_04988","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Propranolol and Labetalol both interact with a specific agent. Evidence indicates that pretreatment with Propranolol significantly shifted the dose-response ... | |
medium_convergence_04989 | CHUK and CD14 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Although IKKalpha and IKKbeta can undergo homotypic interaction, they also interact with each other and the functional IKK complex contains both subunits.' Which protein is encoded by the gene correspondin... | Inhibitor of nuclear factor kappa-B kinase subunit beta | Medium | convergence | {"qa_id":"medium_convergence_04989","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and CD14 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'Although IKKalpha and IKKbeta can undergo ... | |
medium_convergence_04990 | DDB1 and UHRF1 both interact with a specific gene product. Evidence regarding this shared entity states: 'We identified three ubiquitylated lysine residues and showed that DNA ligase I interacts with and is targeted for ubiquitylation by DCAF7, a specificity factor for the Cul4-DDB1 complex.' Which protein is encoded b... | DNA ligase 1 | Medium | convergence | {"qa_id":"medium_convergence_04990","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDB1 and UHRF1 both interact with a specific gene product. Evidence regarding this shared entity states: 'We identified three ubiquitylated lysine residues a... | |
medium_convergence_04991 | YAP1 and BAIAP2 share a common interaction partner. Evidence regarding this shared partner states: 'Binding of the protein encoded by the ATN1 gene to IRSp53 was ascertained by co-immunoprecipitation with antibodies and also by co-localization in perinuclear oval dots in cells expressing engineered constructs.' Which p... | Atrophin-1 | Medium | convergence | {"qa_id":"medium_convergence_04991","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and BAIAP2 share a common interaction partner. Evidence regarding this shared partner states: 'Binding of the protein encoded by the ATN1 gene to IRSp53... | |
medium_convergence_04992 | CENPC and CENPT each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The CENP-T·CENP-W complex is a recently identified inner centromere component that plays crucial roles in the formation of a functional kinetochore involved in cell division during mitosis.' Whi... | Centromere protein W | Medium | convergence | {"qa_id":"medium_convergence_04992","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPC and CENPT each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The CENP-T·CENP-W complex is a ... | |
medium_convergence_04993 | Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of approximately -7.325 and an adjusted p-value of 0.04159. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_04993","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE... | |
medium_convergence_04994 | Both Zaire ebolavirus and Zika virus are known to downregulate the expression of a specific gene. In a study of retinal pigment epithelium cells (GSE100839), the downregulation of this gene was associated with a log2 fold change of approximately -1.252 and an adjusted p-value of 0.001835. Which protein is known to bind... | THRSP | Medium | convergence | {"qa_id":"medium_convergence_04994","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Zaire ebolavirus and Zika virus are known to downregulate the expression of a specific gene. In a study of retinal pigment epithelium cells (GSE100839),... | |
medium_convergence_04995 | RRAGA and ATP6V1C1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports that Rag A was associated with both Rag C and Rag D in their C-terminal regions, where a potential leucine zipper motif and a coiled-coil structure were found. Which protein is encoded by that entit... | Ras-related GTP-binding protein D | Medium | convergence | {"qa_id":"medium_convergence_04995","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RRAGA and ATP6V1C1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports that Rag A was associated with both... | |
medium_convergence_04996 | Both Vaccinia virus and Enterovirus A are known to downregulate a specific host gene. In a study of cervical adenocarcinoma cell lines (GSE11238), the expression of this shared target gene was found to have a log2 fold change of approximately -1.052 and an adjusted p-value of 0.009526. Which biological process is this ... | androgen catabolic process | Medium | convergence | {"qa_id":"medium_convergence_04996","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Enterovirus A are known to downregulate a specific host gene. In a study of cervical adenocarcinoma cell lines (GSE11238), the expres... | |
medium_convergence_04997 | Triprolidine and Scopolamine both interact with a specific shared drug. Evidence indicates that combinations of this shared drug with other antiparkinsonian agents, such as Scopolamine and diphenhydramine, were studied regarding the manifestation of Parkinson-like symptoms in animal models. Which disease is this shared... | swine influenza | Medium | convergence | {"qa_id":"medium_convergence_04997","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Triprolidine and Scopolamine both interact with a specific shared drug. Evidence indicates that combinations of this shared drug with other antiparkinsonian ... | |
medium_convergence_04998 | The biological processes 'regulation of ketone catabolic process' and 'regulation of aldosterone metabolic process' share a common parent process. Evidence regarding this shared parent process states: 'Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the break... | ketone metabolic process | Medium | convergence | {"qa_id":"medium_convergence_04998","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'regulation of ketone catabolic process' and 'regulation of aldosterone metabolic process' share a common parent process. Evidence r... | |
medium_convergence_04999 | CBX3 and PARP1 both interact with a shared protein. Evidence indicates that this protein is an E3 ubiquitin ligase that engages in a physical and functional poly(ADP-ribose)-mediated interaction with PARP1, influencing specific cellular processes. Which disease is associated with this protein through genomic alteration... | gastric cancer | Medium | convergence | {"qa_id":"medium_convergence_04999","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and PARP1 both interact with a shared protein. Evidence indicates that this protein is an E3 ubiquitin ligase that engages in a physical and functional ... | |
medium_convergence_05000 | CLTC and GAK both interact with a shared protein partner. Experimental evidence indicates that in vitro binding and coimmunoprecipitation assays identified the clathrin heavy chain as the major binding partner of this shared partner. Which protein is encoded by this shared partner? | Phosphatidylinositol-binding clathrin assembly protein | Medium | convergence | {"qa_id":"medium_convergence_05000","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLTC and GAK both interact with a shared protein partner. Experimental evidence indicates that in vitro binding and coimmunoprecipitation assays identified t... | |
medium_convergence_05001 | Hepacivirus C and Zaire ebolavirus both upregulate a specific host gene. Experimental data from peripheral blood mononuclear cells (study GSE119117) indicate that this gene has a log2 fold change of approximately 1.675 and an adjusted p-value of 1.259e-06. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05001","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Zaire ebolavirus both upregulate a specific host gene. Experimental data from peripheral blood mononuclear cells (study GSE119117) indicate... | |
medium_convergence_05002 | ERCC4 and FANCG share a common interacting partner. Evidence indicates that this shared partner binds the XPF and MUS81 subunits of the XPF-ERCC1 and MUS81-EME1 endonucleases and is required for DNA interstrand crosslink repair. Which protein is encoded by this shared partner? | Structure-specific endonuclease subunit SLX1 | Medium | convergence | {"qa_id":"medium_convergence_05002","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC4 and FANCG share a common interacting partner. Evidence indicates that this shared partner binds the XPF and MUS81 subunits of the XPF-ERCC1 and MUS81-E... | |
medium_convergence_05003 | Both Human mastadenovirus C and Primate bocaparvovirus 1 are reported to upregulate a specific shared gene. Experimental data for this gene in lung fibroblast cell lines (study GSE120891) indicates a log2 fold change of approximately 1.418 and an adjusted p-value of approximately 0.0459. Which protein does this upregul... | SLC2A1 | Medium | convergence | {"qa_id":"medium_convergence_05003","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Primate bocaparvovirus 1 are reported to upregulate a specific shared gene. Experimental data for this gene in lung fibroblas... | |
medium_convergence_05004 | HSP90AA1 and PDPK1 share multiple interacting partners. One such partner is implicated in a study stating: 'In the present study we demonstrate that the hydrophobic motifs of PKCzeta and PKCiota, as well as PRK1 and PRK2, interact with the kinase domain of PDK1.' Which protein is encoded by the gene corresponding to th... | Protein kinase C iota type | Medium | convergence | {"qa_id":"medium_convergence_05004","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and PDPK1 share multiple interacting partners. One such partner is implicated in a study stating: 'In the present study we demonstrate that the hydr... | |
medium_convergence_05006 | PTK2 and RAF1 both interact with a shared Ras-related protein. Evidence regarding this specific protein states: 'The X-ray crystal structure of the complex between the Ras-related protein [ENTITY] in the GTP-analogue (GppNHp) form and the Ras-binding domain (RBD) of the Ras effector molecule c-Raf1, a Ser/Thr-specific ... | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_05006","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PTK2 and RAF1 both interact with a shared Ras-related protein. Evidence regarding this specific protein states: 'The X-ray crystal structure of the complex b... | |
medium_convergence_05007 | HDAC1 and HIST1H4A share multiple binding partners. One such shared partner is part of an affinity-purified HDAC1 corepressor complex, with evidence suggesting that MeCP1 corresponds to a fraction of this complex. Which gene interacts with this specific shared partner? | MTA1 | Medium | convergence | {"qa_id":"medium_convergence_05007","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and HIST1H4A share multiple binding partners. One such shared partner is part of an affinity-purified HDAC1 corepressor complex, with evidence suggesti... | |
medium_convergence_05008 | NUB1 and PSMA6 both interact with a common protein partner. Evidence regarding this shared partner states: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which protein is encoded by this shared pa... | Proteasome subunit alpha type-7 | Medium | convergence | {"qa_id":"medium_convergence_05008","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUB1 and PSMA6 both interact with a common protein partner. Evidence regarding this shared partner states: 'In the present study, we demonstrate that the 20S... | |
medium_convergence_05009 | RAD9B and BRCA1 both interact with a common protein partner. Evidence indicates that BRCA1 interacts directly with this partner and stimulates its helicase and exonuclease activities in vitro. Which protein is encoded by this common partner? | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | Medium | convergence | {"qa_id":"medium_convergence_05009","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD9B and BRCA1 both interact with a common protein partner. Evidence indicates that BRCA1 interacts directly with this partner and stimulates its helicase a... | |
medium_convergence_05010 | Dengue virus and Pegivirus C both downregulate a specific host gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of -1.072 and an adjusted p-value of 0.03356. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_05010","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Pegivirus C both downregulate a specific host gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2... | |
medium_convergence_05011 | Measles morbillivirus and Dengue virus both upregulate a specific gene. Experimental data for this gene reports a log2 fold change of approximately 1.157 and an adjusted p-value of 0.003407. In which cell type is this gene enriched? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_05011","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Dengue virus both upregulate a specific gene. Experimental data for this gene reports a log2 fold change of approximately 1.157 and... | |
medium_convergence_05012 | EPHB3 and ARHGEF7 both interact with a specific adaptor protein. Evidence indicates that in the brain, Piccolo forms a complex with this adaptor protein along with various GIT-associated proteins, including betaPIX, focal adhesion kinase, liprin-alpha, and paxillin. Which protein is encoded by this adaptor protein? | ARF GTPase-activating protein GIT1 | Medium | convergence | {"qa_id":"medium_convergence_05012","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPHB3 and ARHGEF7 both interact with a specific adaptor protein. Evidence indicates that in the brain, Piccolo forms a complex with this adaptor protein alon... | |
medium_convergence_05013 | CDKN2A and H2AX each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Here we demonstrate a novel p53-independent interaction between the nucleolar tumor suppressors, p14 Arf and Werners helicase.' Which protein is connected to that entity through the 'encodes' relationsh... | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | Medium | convergence | {"qa_id":"medium_convergence_05013","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN2A and H2AX each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Here we demonstrate a novel p53-indepen... | |
medium_convergence_05014 | YWHAG and BTRC both interact with a shared protein. Evidence for the interaction between this shared protein and BTRC (also known as β-TrCP) specifically cites a co-immunoprecipitation assay. Which protein product is encoded by this shared protein? | Disks large homolog 5 | Medium | convergence | {"qa_id":"medium_convergence_05014","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAG and BTRC both interact with a shared protein. Evidence for the interaction between this shared protein and BTRC (also known as β-TrCP) specifically cit... | |
medium_convergence_05015 | CC2D1B and CHMP2A both interact with a shared protein partner. Evidence indicates that the ESCRT-III component CHMP2A is directed to the forming nuclear envelope through binding to this specific partner, an interaction essential for nuclear envelope reformation. Which protein is encoded by the gene corresponding to thi... | Charged multivesicular body protein 4b | Medium | convergence | {"qa_id":"medium_convergence_05015","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CC2D1B and CHMP2A both interact with a shared protein partner. Evidence indicates that the ESCRT-III component CHMP2A is directed to the forming nuclear enve... | |
medium_convergence_05016 | AFF4 and EAF1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports: 'Using specific antibodies, the endogenous EAF1 and this protein were coimmunoprecipitated from multiple cell lines.' Which protein is encoded by that shared entity? | RNA polymerase II elongation factor ELL | Medium | convergence | {"qa_id":"medium_convergence_05016","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AFF4 and EAF1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports: 'Using specific antibodies, ... | |
medium_convergence_05018 | AKAP8 and PKN1 both interact with a specific protein. Evidence indicates that this protein, referred to as RIIalpha, coimmunoprecipitates with AKAP95 from HeLa cells arrested in mitosis, but not from interphase HeLa cells, demonstrating a physical association during mitosis. Which protein is encoded by the gene corresp... | cAMP-dependent protein kinase type II-alpha regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_05018","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP8 and PKN1 both interact with a specific protein. Evidence indicates that this protein, referred to as RIIalpha, coimmunoprecipitates with AKAP95 from He... | |
medium_convergence_05019 | ARPC1A and ARHGEF7 share multiple binding partners. One of these shared partners was identified as a Cool family binding partner using a yeast two-hybrid screen. Which disease is associated with this specific shared partner via a biomarker relationship? | uniparental disomy | Medium | convergence | {"qa_id":"medium_convergence_05019","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC1A and ARHGEF7 share multiple binding partners. One of these shared partners was identified as a Cool family binding partner using a yeast two-hybrid scr... | |
medium_convergence_05020 | BRD8 and EP400 share multiple protein interaction partners. One such partner was identified as interacting with BRD8 through yeast two-hybrid screening and subsequent immunoprecipitation analysis. Which disease is associated with this specific interaction partner? | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_05020","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD8 and EP400 share multiple protein interaction partners. One such partner was identified as interacting with BRD8 through yeast two-hybrid screening and s... | |
medium_convergence_05021 | Aldesleukin and Cimetidine both interact with a specific drug. Clinical evidence indicates that this drug, along with Ketoconazole and erythromycin, inhibits the metabolism of newer hypnosedatives and enhances their sedative effects, suggesting that a dose reduction may be required. Which disease is this drug indicated... | insomnia | Medium | convergence | {"qa_id":"medium_convergence_05021","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Aldesleukin and Cimetidine both interact with a specific drug. Clinical evidence indicates that this drug, along with Ketoconazole and erythromycin, inhibits... | |
medium_convergence_05022 | G3BP1 and C1QBP both interact with a specific shared protein. Evidence indicates that p32 acts as a key regulator of this shared protein's stability by forming a complex with it. Which protein is encoded by the gene corresponding to this shared entity? | Serine/threonine-protein kinase ULK1 | Medium | convergence | {"qa_id":"medium_convergence_05022","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"G3BP1 and C1QBP both interact with a specific shared protein. Evidence indicates that p32 acts as a key regulator of this shared protein's stability by formi... | |
medium_convergence_05023 | Both CAMK2A and CAMK2B interact with a shared protein partner. Evidence indicates that the binding of CaMKII to the NR2B subunit of the NMDA receptor in the postsynaptic density is essential for the induction of long-term potentiation. Which protein, encoded by the gene corresponding to this shared partner, is linked t... | Glutamate receptor ionotropic, NMDA 2A | Medium | convergence | {"qa_id":"medium_convergence_05023","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both CAMK2A and CAMK2B interact with a shared protein partner. Evidence indicates that the binding of CaMKII to the NR2B subunit of the NMDA receptor in the ... | |
medium_convergence_05024 | MRE11A and MDC1 both interact with a specific protein. Evidence indicates that this protein facilitates the accumulation of checkpoint mediator proteins BRCA1 and 53BP1 at damaged chromatin, partly through phospho-dependent binding via its FHA domain to MDC1. Which protein is encoded by the gene corresponding to this i... | E3 ubiquitin-protein ligase RNF8 | Medium | convergence | {"qa_id":"medium_convergence_05024","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MRE11A and MDC1 both interact with a specific protein. Evidence indicates that this protein facilitates the accumulation of checkpoint mediator proteins BRCA... | |
medium_convergence_05025 | POLR2B and PIH1D1 share a common interacting partner. Experimental evidence indicates that this shared partner interacts with both PIH1D1 and Monad in HEK293 or U2OS cells. Which protein is encoded by this shared interacting partner? | RNA polymerase II-associated protein 3 | Medium | convergence | {"qa_id":"medium_convergence_05025","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLR2B and PIH1D1 share a common interacting partner. Experimental evidence indicates that this shared partner interacts with both PIH1D1 and Monad in HEK293... | |
medium_convergence_05026 | Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data for this gene in retinal pigment epithelium cells (study GSE100839) shows a log2 fold change of -2.106 and an adjusted p-value of 1.34e-05. Which disease is associated with this gene as a biomarker? | major depressive disorder | Medium | convergence | {"qa_id":"medium_convergence_05026","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data for this gene in retinal pigment epithelium cells (study GSE100839) show... | |
medium_convergence_05027 | MYC and BRCA1 share common interaction partners. One such shared partner is implicated in a study stating: 'Our biochemical and genomic analyses showed that the BRCA1-BARD1 complex interacts with this protein in the nucleus'. Which protein is encoded by this shared interaction partner? | DNA topoisomerase 2-beta | Medium | convergence | {"qa_id":"medium_convergence_05027","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and BRCA1 share common interaction partners. One such shared partner is implicated in a study stating: 'Our biochemical and genomic analyses showed that ... | |
medium_convergence_05028 | SMAD1 and MTA2 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'We have identified the 30-zinc finger protein [REDACTED] as a DNA-binding factor that associates with Smads in response to BMP2, forming a complex that transcriptionally activates the homeobox regulator of ... | Zinc finger protein 423 | Medium | convergence | {"qa_id":"medium_convergence_05028","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD1 and MTA2 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'We have identified the 30-zinc finger prote... | |
medium_convergence_05029 | Measles morbillivirus and Pegivirus C both upregulate a shared gene. Evidence for one such shared gene reports a log2 fold change of 2.556 and an adjusted p-value of 0.0007655. Which protein is encoded by that gene? | Histone H4 | Medium | convergence | {"qa_id":"medium_convergence_05029","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Pegivirus C both upregulate a shared gene. Evidence for one such shared gene reports a log2 fold change of 2.556 and an adjusted p-... | |
medium_convergence_05031 | Hepacivirus C and Zaire ebolavirus both upregulate a specific gene. Evidence for this shared target in peripheral blood mononuclear cells (from study GSE119117) reports a log2 fold change of 1.738 and an adjusted p-value of 0.04519. Which protein is encoded by this gene? | Phospholipase A and acyltransferase 4 | Medium | convergence | {"qa_id":"medium_convergence_05031","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Zaire ebolavirus both upregulate a specific gene. Evidence for this shared target in peripheral blood mononuclear cells (from study GSE1191... | |
medium_convergence_05032 | ASB18 and CUL5 share multiple binding partners. One shared partner is involved in a tricomplex with PRDX1 oligomers and CUL5, which is critical for CUL5 neddylation. This partner is described as a Nedd8-conjugating enzyme. Which protein encodes this Nedd8-conjugating enzyme? | NEDD8-conjugating enzyme UBE2F | Medium | convergence | {"qa_id":"medium_convergence_05032","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ASB18 and CUL5 share multiple binding partners. One shared partner is involved in a tricomplex with PRDX1 oligomers and CUL5, which is critical for CUL5 nedd... | |
medium_convergence_05033 | ABI2 and EVL both interact with a shared protein. Experimental evidence indicates that this shared protein, along with MENA and EVL, mutually interacts as revealed by surface plasmon resonance analyses. Which protein is encoded by this shared entity? | Vasodilator-stimulated phosphoprotein | Medium | convergence | {"qa_id":"medium_convergence_05033","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ABI2 and EVL both interact with a shared protein. Experimental evidence indicates that this shared protein, along with MENA and EVL, mutually interacts as re... | |
medium_convergence_05034 | ACTR1A and ARCN1 both interact with a shared protein partner. Evidence regarding this partner states: 'Using a photocrosslinking approach, we find that under native conditions a peptide analogous to the cytoplasmic domain of p23 interacts with coatomer exclusively through its gamma subunit and shares its binding site w... | Golgi membrane | Medium | convergence | {"qa_id":"medium_convergence_05034","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR1A and ARCN1 both interact with a shared protein partner. Evidence regarding this partner states: 'Using a photocrosslinking approach, we find that under... | |
medium_convergence_05035 | YAP1 and COPS5 share multiple interacting partners. One such shared partner is the subject of evidence stating: 'We confirmed a direct interaction of Jab1 with LMP-1 using recombinantly expressed wild-type and mutant proteins in slot-blot-binding assays.' Which biological process is this shared partner involved in? | receptor-mediated endocytosis | Medium | convergence | {"qa_id":"medium_convergence_05035","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and COPS5 share multiple interacting partners. One such shared partner is the subject of evidence stating: 'We confirmed a direct interaction of Jab1 wi... | |
medium_convergence_05036 | Both Human alphaherpesvirus 3 and Zika virus downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of approximately -1.078 and an adjusted p-value of approximately 2.447e-06. Which biological process is this gene involved in? | response to X-ray | Medium | convergence | {"qa_id":"medium_convergence_05036","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zika virus downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a ... | |
medium_convergence_05037 | EPS15L1 and CBL each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we demonstrate that h[entity] associates directly with c-Cbl, a known down-regulator of RTK signaling.' Which cell type is that entity enriched in? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_05037","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPS15L1 and CBL each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here, we demonstrate that h[entity] associat... | |
medium_convergence_05038 | CHMP4B and CHMP4C both interact with a specific protein. Experimental evidence indicates that in a yeast two-hybrid assay, HD-PTP showed positive interactions with this protein (also known as Shax1), endophilin A1, and ALG-2, but not with RabGAPLP or CIN85. Which disease is associated with this protein? | microcephaly 29, primary, autosomal recessive | Medium | convergence | {"qa_id":"medium_convergence_05038","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP4B and CHMP4C both interact with a specific protein. Experimental evidence indicates that in a yeast two-hybrid assay, HD-PTP showed positive interaction... | |
medium_convergence_05039 | FAF2 and NSFL1C both interact with a shared protein partner. Evidence regarding this partner states: 'Now we have identified a novel essential factor for p97/p47-mediated membrane fusion, named [shared partner] (valosin-containing protein [VCP][p97]/p47 complex-interacting protein, p135), and show that it binds to the ... | Deubiquitinating protein VCPIP1 | Medium | convergence | {"qa_id":"medium_convergence_05039","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAF2 and NSFL1C both interact with a shared protein partner. Evidence regarding this partner states: 'Now we have identified a novel essential factor for p97... | |
medium_convergence_05040 | PHB2 and BRD4 both interact with a shared protein. Evidence for one such shared partner states: 'In the present study, using the yeast two-hybrid system, we have found that this protein interacts with the PHB2 protein.' Which disease is associated with this specific shared protein? | Luo-Schoch-Yamamoto syndrome | Medium | convergence | {"qa_id":"medium_convergence_05040","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PHB2 and BRD4 both interact with a shared protein. Evidence for one such shared partner states: 'In the present study, using the yeast two-hybrid system, we ... | |
medium_convergence_05041 | HOXA1 and TIFAB are both involved in more than one shared biological process. One of these shared processes is associated with a phenotype characterized by horizontal gaze abnormalities, deafness, facial weakness, hypoventilation, vascular malformations of the internal carotid arteries and cardiac outflow tract, mental... | anatomical structure development | Medium | convergence | {"qa_id":"medium_convergence_05041","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HOXA1 and TIFAB are both involved in more than one shared biological process. One of these shared processes is associated with a phenotype characterized by h... | |
medium_convergence_05042 | Human mastadenovirus C and Primate bocaparvovirus 1 are both reported to upregulate a specific gene. Experimental data for this gene in lung fibroblast cell lines (study GSE120891) shows a log2 fold change of approximately 2.78 and an adjusted p-value of approximately 0.038. Which protein is encoded by this gene? | Inhibin beta A chain | Medium | convergence | {"qa_id":"medium_convergence_05042","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human mastadenovirus C and Primate bocaparvovirus 1 are both reported to upregulate a specific gene. Experimental data for this gene in lung fibroblast cell ... | |
medium_convergence_05043 | CHD4 and CTBP1 both interact with a shared protein complex component. Evidence regarding this component states: 'We identify HDAC1/2, [REDACTED], and Ubc9 (E2) as the core constituents of the CtBP1 complex, and these components interact with the PLDLS cleft region through non-PLDLS interactions.' Which protein is encod... | REST corepressor 1 | Medium | convergence | {"qa_id":"medium_convergence_05043","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and CTBP1 both interact with a shared protein complex component. Evidence regarding this component states: 'We identify HDAC1/2, [REDACTED], and Ubc9 (E... | |
medium_convergence_05044 | Cardiovirus A and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -1.113 and an adjusted p-value of 0.02468. Which protein is encoded by this gene? | DmX-like protein 2 | Medium | convergence | {"qa_id":"medium_convergence_05044","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cardiovirus A and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967... | |
medium_convergence_05045 | MNAT1 and DTL both interact with a shared protein partner. Experimental evidence indicates that complexes containing this partner were isolated from HeLa cells and found to associate with DDB1, components of the COP9-signalosome complex (CSN), and the partner itself. Which protein is encoded by this shared partner? | DNA sliding clamp PCNA | Medium | convergence | {"qa_id":"medium_convergence_05045","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MNAT1 and DTL both interact with a shared protein partner. Experimental evidence indicates that complexes containing this partner were isolated from HeLa cel... | |
medium_convergence_05046 | CD226 and NECTIN2 are both involved in more than one shared biological process. Evidence concerning one of these shared processes indicates that the associated entity synergizes with FcepsilonRI on mast cells, and its engagement augments degranulation through a pathway involving Fyn, linker of activation of T-cells, ph... | mast cell activation | Medium | convergence | {"qa_id":"medium_convergence_05046","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CD226 and NECTIN2 are both involved in more than one shared biological process. Evidence concerning one of these shared processes indicates that the associat... | |
medium_convergence_05047 | MDM2 and TP53 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with both MDM2 and TP53 in both in vivo and in vitro settings. Which protein is encoded by this shared entity? | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | Medium | convergence | {"qa_id":"medium_convergence_05047","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and TP53 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with both MDM2 and TP53 in both in vivo and... | |
medium_convergence_05048 | Cyclosporine and Dasatinib share a common interacting drug. Evidence regarding this shared drug indicates that a pharmacokinetic model performed well in recovering the observed effects of the CYP3A4 inhibitors ketoconazole and this shared drug, as well as the CYP3A4 inducer rifampicin, and in predicting interactions wi... | pulmonary arterial hypertension | Medium | convergence | {"qa_id":"medium_convergence_05048","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cyclosporine and Dasatinib share a common interacting drug. Evidence regarding this shared drug indicates that a pharmacokinetic model performed well in reco... | |
medium_convergence_05049 | EP300 and GSK3B share multiple interacting partners. One such shared partner is involved in a process where DNA binding enhances the direct interaction between the C-terminal domain of this partner and GSK-3beta. Which protein is encoded by this shared partner? | Sterol regulatory element-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05049","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and GSK3B share multiple interacting partners. One such shared partner is involved in a process where DNA binding enhances the direct interaction betwe... | |
medium_convergence_05050 | UBR3 and CBX5 share a common interacting partner. Evidence regarding this shared partner states: 'Our study indicates that RAD6 physically interacts with HP1α and ubiquitinates HP1α at residue K154, thereby promoting HP1α degradation through the autophagy pathway and eventually leading to an open chromatin structure th... | Ubiquitin-conjugating enzyme E2 A | Medium | convergence | {"qa_id":"medium_convergence_05050","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBR3 and CBX5 share a common interacting partner. Evidence regarding this shared partner states: 'Our study indicates that RAD6 physically interacts with HP1... | |
medium_convergence_05051 | Hepacivirus C and Dengue virus both upregulate a specific gene. Experimental data for this gene in hepatocytes (from study GSE132606) reports a log2 fold change of approximately 1.72 and an adjusted p-value of approximately 0.0023. Which protein does this gene product interact with? | BIRC6 | Medium | convergence | {"qa_id":"medium_convergence_05051","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Dengue virus both upregulate a specific gene. Experimental data for this gene in hepatocytes (from study GSE132606) reports a log2 fold cha... | |
medium_convergence_05052 | Hepacivirus C and Zaire ebolavirus both upregulate a specific gene. Evidence for this gene in peripheral blood mononuclear cells (from study GSE119117) reports a log2 fold change of 1.043 and an adjusted p-value of 0.001097. Which cellular component is this gene located in? | endoplasmic reticulum | Medium | convergence | {"qa_id":"medium_convergence_05052","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Zaire ebolavirus both upregulate a specific gene. Evidence for this gene in peripheral blood mononuclear cells (from study GSE119117) repor... | |
medium_convergence_05053 | Fluconazole and Sirolimus both interact with a specific drug. Evidence regarding this shared interaction partner notes that these agents have been shown to notably decrease the catabolism of numerous drugs, specifically mentioning this entity. Which disease is this entity indicated for? | insomnia | Medium | convergence | {"qa_id":"medium_convergence_05053","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Fluconazole and Sirolimus both interact with a specific drug. Evidence regarding this shared interaction partner notes that these agents have been shown to n... | |
medium_convergence_05056 | BMP8A and BMP4 both interact with a specific receptor. Experimental evidence indicates that in transfected COS-1 cells, osteogenic protein (OP)-1/BMP-7, and less efficiently BMP-4, bound to this receptor. Which disease is associated with this receptor as a biomarker? | anemia due to chronic disorder | Medium | convergence | {"qa_id":"medium_convergence_05056","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP8A and BMP4 both interact with a specific receptor. Experimental evidence indicates that in transfected COS-1 cells, osteogenic protein (OP)-1/BMP-7, and ... | |
medium_convergence_05057 | H2AX and BRCC3 both interact with a specific protein. Evidence indicates that this protein and SMURF2 act as a stabilizer and destabilizer of H2AX, respectively, through their dynamic interactions with it. Which protein is this? | E3 ubiquitin-protein ligase RNF168 | Medium | convergence | {"qa_id":"medium_convergence_05057","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H2AX and BRCC3 both interact with a specific protein. Evidence indicates that this protein and SMURF2 act as a stabilizer and destabilizer of H2AX, respectiv... | |
medium_convergence_05058 | HSPA9 and OTC both interact with a shared mitochondrial protein. Evidence indicates that this shared entity is a peripheral inner-membrane protein that tethers the complex to the import channel. Which protein is encoded by the gene corresponding to this shared entity? | Mitochondrial import inner membrane translocase subunit TIM44 | Medium | convergence | {"qa_id":"medium_convergence_05058","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA9 and OTC both interact with a shared mitochondrial protein. Evidence indicates that this shared entity is a peripheral inner-membrane protein that tethe... | |
medium_convergence_05059 | COPS6 and COPS4 each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that TA binds CSN4 and the synaptic regulator snapin in neuroblastoma cells and in brain synaptosomes. Which protein is encoded by the gene corresponding to that shared partner? | Torsin-1A | Medium | convergence | {"qa_id":"medium_convergence_05059","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS6 and COPS4 each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that TA binds CSN4 and the syn... | |
medium_convergence_05060 | Troglitazone and Morphine share a common interacting drug. Evidence regarding one such shared entity states: 'Although chronic treatment with this drug significantly enhanced morphine-induced hyperlocomotion, this enhancement of morphine-induced hyperlocomotion was suppressed by treating it with the mGlu5 receptor anta... | insomnia | Medium | convergence | {"qa_id":"medium_convergence_05060","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Troglitazone and Morphine share a common interacting drug. Evidence regarding one such shared entity states: 'Although chronic treatment with this drug signi... | |
medium_convergence_05062 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific host gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of -1.204 and an adjusted p-value of 3.472e-08. Which cellular component is this ge... | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_05062","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific host gene. Experimental data for... | |
medium_convergence_05063 | BET1 and STX17 share a common interaction partner. Evidence indicates that a specific isoform of this shared partner, characterized by a disrupted SNARE domain, competes with the functional SNARE domain isoform to bind to STX17, thereby inhibiting autophagosome-lysosome fusion. Which protein is encoded by this shared i... | Vesicle-associated membrane protein 7 | Medium | convergence | {"qa_id":"medium_convergence_05063","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BET1 and STX17 share a common interaction partner. Evidence indicates that a specific isoform of this shared partner, characterized by a disrupted SNARE doma... | |
medium_convergence_05064 | BIRC2 and BIRC3 both interact with a shared protein. Evidence indicates that this shared protein interacts with other members of the TNFR-1 signaling complex, including the inhibitor of apoptosis protein cIAP1, and with specific members of the TNFR-associated factor (TRAF) family (TRAF1, TRAF5, and TRAF6), but does not... | obesity disorder | Medium | convergence | {"qa_id":"medium_convergence_05064","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and BIRC3 both interact with a shared protein. Evidence indicates that this shared protein interacts with other members of the TNFR-1 signaling complex... | |
medium_convergence_05065 | EGFR and ERBB4 both interact with a specific shared protein. Experimental evidence indicates that a 35S-labeled SH2 fusion protein derived from a non-receptor tyrosine kinase binds to this shared entity when it is immunoprecipitated from EGF-treated NIH3T3 cells overexpressing the receptor. Which disease is associated ... | T-cell childhood acute lymphocytic leukemia | Medium | convergence | {"qa_id":"medium_convergence_05065","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and ERBB4 both interact with a specific shared protein. Experimental evidence indicates that a 35S-labeled SH2 fusion protein derived from a non-recepto... | |
medium_convergence_05066 | PCNA and RAD18 share interaction partners. One such shared partner is described by evidence stating: 'We found that this protein interacts physically with RAD18 and interferes with the binding of RAD18 to forked DNA and to template/primer DNA.' Which protein is encoded by this shared partner? | ATPase WRNIP1 | Medium | convergence | {"qa_id":"medium_convergence_05066","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PCNA and RAD18 share interaction partners. One such shared partner is described by evidence stating: 'We found that this protein interacts physically with RA... | |
medium_convergence_05067 | HSPA5 and NFE2L2 share common interacting partners. One such shared partner is involved in an interaction with Nrf2 that was verified by GST pull-down and immunocytochemical assays, showing that E-cadherin binds the C-terminus of Nrf2 but not its N-terminus (which contains the Neh2 domain responsible for Ser40 phosphor... | Cadherin-1 | Medium | convergence | {"qa_id":"medium_convergence_05067","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA5 and NFE2L2 share common interacting partners. One such shared partner is involved in an interaction with Nrf2 that was verified by GST pull-down and im... | |
medium_convergence_05068 | DIS3 and EXOSC5 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Here, we demonstrate the association of two different Dis3p homologs--hDIS3 and hDIS3L--with the human exosome core.' Which protein is connected to that entity through the 'encodes' relationship? | Exosome complex component RRP45 | Medium | convergence | {"qa_id":"medium_convergence_05068","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DIS3 and EXOSC5 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Here, we demonstrate the association... | |
medium_convergence_05069 | EP300 and HDAC2 both interact with a specific shared protein. Evidence indicates that this protein interacts with the transcriptional coactivator p300, resulting in the acetylation of the protein on two lysine residues in its N terminus. Which disease is therapeutically connected to this protein? | pulmonary fibrosis | Medium | convergence | {"qa_id":"medium_convergence_05069","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and HDAC2 both interact with a specific shared protein. Evidence indicates that this protein interacts with the transcriptional coactivator p300, resul... | |
medium_convergence_05070 | Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 fold change of approximately 1.404 and an adjusted p-value of 0.002558. Which protein is encoded by this gene? | Zinc finger CCCH-type antiviral protein 1 | Medium | convergence | {"qa_id":"medium_convergence_05070","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Zika virus both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 ... | |
medium_convergence_05071 | HSPA1A and HSPA8 both interact with a shared protein partner. For one such partner, evidence indicates that the interaction was identified by interactome analysis and structurally determined by X-ray crystallography and NMR analyses. Which biological process is this specific shared partner involved in? | tRNA aminoacylation for protein translation | Medium | convergence | {"qa_id":"medium_convergence_05071","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA1A and HSPA8 both interact with a shared protein partner. For one such partner, evidence indicates that the interaction was identified by interactome ana... | |
medium_convergence_05073 | Both F3 and F10 share a binding partner with a specific protein. Evidence indicates that blood coagulation is triggered by the formation of a complex between factor VIIa (FVIIa) and its cofactor, tissue factor (TF). Which protein, connected to this shared entity via an 'encodes' relationship, is the subject of this evi... | Coagulation factor VII | Medium | convergence | {"qa_id":"medium_convergence_05073","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both F3 and F10 share a binding partner with a specific protein. Evidence indicates that blood coagulation is triggered by the formation of a complex between... | |
medium_convergence_05074 | BABAM1 and HIF1AN both interact with a specific protein. Experimental evidence indicates that MERIT40, a core component of the BRISC complex, directly interacts with the RXXPEG motif in the ARC-V domain of this protein, which is identified as Tankyrase1. Which protein is encoded by the gene corresponding to this entity... | Poly [ADP-ribose] polymerase tankyrase-1 | Medium | convergence | {"qa_id":"medium_convergence_05074","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BABAM1 and HIF1AN both interact with a specific protein. Experimental evidence indicates that MERIT40, a core component of the BRISC complex, directly intera... | |
medium_convergence_05075 | DIDO1 and SMC3 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with the structural maintenance of chromosomes proteins SMC1 and SMC3, which are subunits of the mitotic cohesin complex. Which protein product is encoded by this shared protein? | Cohesin subunit SA-3 | Medium | convergence | {"qa_id":"medium_convergence_05075","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DIDO1 and SMC3 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with the structural maintenance of chromos... | |
medium_convergence_05076 | DDB1 and NPM1 both interact with a shared protein. Evidence for this shared protein indicates that recombinant DDB1 and the protein bind directly to each other in vitro, and that ectopically expressed DDB1 bridges the protein to CUL4A in vivo. Which protein is encoded by the gene corresponding to this shared entity? | DNA replication factor Cdt1 | Medium | convergence | {"qa_id":"medium_convergence_05076","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDB1 and NPM1 both interact with a shared protein. Evidence for this shared protein indicates that recombinant DDB1 and the protein bind directly to each oth... | |
medium_convergence_05077 | Human orthopneumovirus and Primate bocaparvovirus 1 are both reported to upregulate a specific gene. Evidence for this upregulation in one instance shows a log2 fold change of 1.177 and an adjusted p-value of 0.03705. Which protein is encoded by this gene? | ADP-ribosylation factor-like protein 4D | Medium | convergence | {"qa_id":"medium_convergence_05077","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human orthopneumovirus and Primate bocaparvovirus 1 are both reported to upregulate a specific gene. Evidence for this upregulation in one instance shows a l... | |
medium_convergence_05078 | HDAC2 and NCOR1 each interact with more than one shared protein. Evidence concerning one of these shared proteins indicates that it binds the N-CoR corepressor and is required for N-CoR-mediated repression by antagonist-bound estrogen receptor and the homeodomain protein Rpx, as well as N-CoR suppression of transactiva... | Histone deacetylase complex subunit SAP30 | Medium | convergence | {"qa_id":"medium_convergence_05078","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC2 and NCOR1 each interact with more than one shared protein. Evidence concerning one of these shared proteins indicates that it binds the N-CoR corepress... | |
medium_convergence_05080 | MYC and BCOR both interact with a shared protein. Evidence regarding this shared protein states: 'Molecular analysis of BCOR K607E mutation revealed that compared to the wild-type BCOR, the mutant BCOR bound to the BCL6, PCGF1, and a component of the PRC1 complex with lesser affinity.' Which disease is associated with ... | Luo-Schoch-Yamamoto syndrome | Medium | convergence | {"qa_id":"medium_convergence_05080","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and BCOR both interact with a shared protein. Evidence regarding this shared protein states: 'Molecular analysis of BCOR K607E mutation revealed that com... | |
medium_convergence_05081 | IKBKB and MAP3K3 each share a binding partner. Evidence concerning one such shared entity states: 'We show that a MAP3K7 family kinase physically interacts with NIK and with IKK2, and both XIAP or active MAP3K7 family kinase can stimulate IKK2 kinase activity.' Which protein is connected to that entity through the 'enc... | Mitogen-activated protein kinase kinase kinase 7 | Medium | convergence | {"qa_id":"medium_convergence_05081","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IKBKB and MAP3K3 each share a binding partner. Evidence concerning one such shared entity states: 'We show that a MAP3K7 family kinase physically interacts w... | |
medium_convergence_05083 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of -2.112 and an adjusted p-value of 0.04933. Which protein is encoded by this gene? | Neural cell adhesion molecule L1 | Medium | convergence | {"qa_id":"medium_convergence_05083","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) ind... | |
medium_convergence_05084 | Zaire ebolavirus and Human gammaherpesvirus 8 both downregulate a specific host gene. In a study of retinal pigment epithelium cells (GSE100839), this gene exhibited a log2 fold change of approximately -1.190 and an adjusted p-value of 0.0002908. Which protein does this downregulated gene interact with? | RELB | Medium | convergence | {"qa_id":"medium_convergence_05084","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Human gammaherpesvirus 8 both downregulate a specific host gene. In a study of retinal pigment epithelium cells (GSE100839), this gene e... | |
medium_convergence_05085 | CHMP5 and TSG101 both bind to a shared protein. Evidence indicates that this shared protein is part of a complex containing a fraction of total cellular TSG101, VPS37A, but not VPS37C. Which gene interacts with this shared protein? | ZFYVE16 | Medium | convergence | {"qa_id":"medium_convergence_05085","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP5 and TSG101 both bind to a shared protein. Evidence indicates that this shared protein is part of a complex containing a fraction of total cellular TSG1... | |
medium_convergence_05086 | ILK and LIMS1 share multiple binding partners. One of these shared partners is described in the following evidence: 'Here, we identified a novel ILK-binding protein, affixin, that consists of two tandem calponin homology domains.' Which disease is associated with this specific shared partner via a biomarker relationshi... | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_05086","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ILK and LIMS1 share multiple binding partners. One of these shared partners is described in the following evidence: 'Here, we identified a novel ILK-binding ... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.