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medium_convergence_06205 | Human alphaherpesvirus 1 and Pegivirus C both upregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), this gene showed a log2 fold change of 2.631 and an adjusted p-value of 0.002812. Which protein is encoded by this gene? | Histone H4 | Medium | convergence | {"qa_id":"medium_convergence_06205","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Pegivirus C both upregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), this gene showed a log... | |
medium_convergence_06206 | CENPS and BLM each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We also provide biochemical evidence that MHF1 and MHF2 assemble into a heterodimer that binds DNA and enhances the DNA branch migration activity of FANCM.' Which protein is connected to that entity through th... | Fanconi anemia core complex-associated protein 100 | Medium | convergence | {"qa_id":"medium_convergence_06206","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPS and BLM each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We also provide biochemical evidence that MHF1... | |
medium_convergence_06207 | BRCA1 and BRIP1 both interact with a common protein partner. Experimental evidence indicates that this shared partner directly binds to BRCA1, a finding established using bacterially expressed fragments of the respective proteins. Which protein is encoded by the gene corresponding to this shared partner? | Partner and localizer of BRCA2 | Medium | convergence | {"qa_id":"medium_convergence_06207","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRCA1 and BRIP1 both interact with a common protein partner. Experimental evidence indicates that this shared partner directly binds to BRCA1, a finding esta... | |
medium_convergence_06208 | Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of 2.658 and an adjusted p-value of 0.0007222. Which protein is encoded by this gene? | Alpha-adducin | Medium | convergence | {"qa_id":"medium_convergence_06208","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE... | |
medium_convergence_06209 | MYRIP and MYO5A each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Consistent with this, the protein present in detergent lysates of melanocytes binds to beads coated with purified, full-length melanocyte myosin Va and melanocyte myosin Va lacking exon D, but n... | Ras-related protein Rab-27A | Medium | convergence | {"qa_id":"medium_convergence_06209","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYRIP and MYO5A each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Consistent with this, the prote... | |
medium_convergence_06210 | DLD and DLST each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Moreover, a high affinity interaction has been demonstrated between the homodimeric E1 and E3 components, which form a stable subcomplex comprising single copies of these two enzymes.' Which p... | 2-oxoglutarate dehydrogenase complex component E1 | Medium | convergence | {"qa_id":"medium_convergence_06210","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLD and DLST each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Moreover, a high affinity int... | |
medium_convergence_06211 | UBQLN2 and MAP3K5 share a common interaction partner. Experimental evidence indicates that this shared partner interacts with the ATPases comprising the 19S regulatory particle of the proteasome, which recognizes polyubiquitinated proteins and translocates them into the 20S catalytic core. Which protein is encoded by t... | 26S proteasome regulatory subunit 4 | Medium | convergence | {"qa_id":"medium_convergence_06211","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBQLN2 and MAP3K5 share a common interaction partner. Experimental evidence indicates that this shared partner interacts with the ATPases comprising the 19S ... | |
medium_convergence_06214 | NCK1 and WASL both interact with a shared protein entity. Experimental evidence indicates that Nck binds to this entity via its second SH3 domain at a specific site (amino acids 321-415), which is distinct from the WASP-binding site (amino acids 416-488). Which gene is connected to this shared entity through an 'intera... | NCK2 | Medium | convergence | {"qa_id":"medium_convergence_06214","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCK1 and WASL both interact with a shared protein entity. Experimental evidence indicates that Nck binds to this entity via its second SH3 domain at a specif... | |
medium_convergence_06215 | BIRC2 and CARD11 both interact with a shared protein. Evidence indicates that EGLN3 competes with cIAP1 for binding to IKKγ, thereby inhibiting the cIAP1-IKKγ interaction, IKKγ ubiquitination, and downstream IKK-NF-κB signaling. Which protein, encoded by the gene corresponding to this shared interaction partner, is the... | NF-kappa-B essential modulator | Medium | convergence | {"qa_id":"medium_convergence_06215","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and CARD11 both interact with a shared protein. Evidence indicates that EGLN3 competes with cIAP1 for binding to IKKγ, thereby inhibiting the cIAP1-IKK... | |
medium_convergence_06216 | HMG20B and KDM1A each interact with more than one shared protein partner. Evidence concerning one of these shared partners describes a transcriptional co-repressor complex containing LSD1, a specific co-repressor protein, and HDAC1 (termed LCH), which represses transcription by coordinately removing histone modificatio... | heparin-induced thrombocytopenia | Medium | convergence | {"qa_id":"medium_convergence_06216","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HMG20B and KDM1A each interact with more than one shared protein partner. Evidence concerning one of these shared partners describes a transcriptional co-rep... | |
medium_convergence_06217 | Digoxin and Cisatracurium share a common interacting drug. Evidence regarding this shared drug indicates that it increases the renal clearance of Digoxin by 2-3 folds, accompanied by a small increase in inulin clearance. Which condition is this shared drug indicated for? | poisoning | Medium | convergence | {"qa_id":"medium_convergence_06217","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Digoxin and Cisatracurium share a common interacting drug. Evidence regarding this shared drug indicates that it increases the renal clearance of Digoxin by ... | |
medium_convergence_06218 | WDR5 and MYC share multiple interacting partners. One such shared partner is reported to directly interact with MYC and co-occupy a distal regulatory element of SOX2 to activate SOX2 expression, a mechanism likely involved in neuroectoderm differentiation. Which gene interacts with this specific shared partner? | CBX4 | Medium | convergence | {"qa_id":"medium_convergence_06218","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WDR5 and MYC share multiple interacting partners. One such shared partner is reported to directly interact with MYC and co-occupy a distal regulatory element... | |
medium_convergence_06219 | WDR5 and GARS1 share a common interaction partner. Evidence regarding this shared partner notes: 'Interestingly, the N-terminal extension of human glycyl-tRNA synthetase containing a single motif homologous to those in the bifunctional tRNA synthetase also interacted with the C-terminal motif of the isoleucyl-tRNA synt... | Isoleucine--tRNA ligase, cytoplasmic | Medium | convergence | {"qa_id":"medium_convergence_06219","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WDR5 and GARS1 share a common interaction partner. Evidence regarding this shared partner notes: 'Interestingly, the N-terminal extension of human glycyl-tRN... | |
medium_convergence_06220 | LCK and SRC both interact with a shared protein. Experimental evidence indicates that immunoprecipitation of this protein from Jurkat cells confirmed its association with LCK in vivo, and that PMA stimulation increased the phosphorylation level of this protein. Which protein is encoded by the gene corresponding to this... | Disintegrin and metalloproteinase domain-containing protein 15 | Medium | convergence | {"qa_id":"medium_convergence_06220","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LCK and SRC both interact with a shared protein. Experimental evidence indicates that immunoprecipitation of this protein from Jurkat cells confirmed its ass... | |
medium_convergence_06221 | EZH2 and CBX4 both interact with a common protein partner. Experimental evidence indicates that Akt phosphorylates this shared partner at serine 21, thereby suppressing its methyltransferase activity by preventing its binding to histone H3. This modification leads to reduced lysine 27 trimethylation and the derepressio... | Histone H3.1 | Medium | convergence | {"qa_id":"medium_convergence_06221","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EZH2 and CBX4 both interact with a common protein partner. Experimental evidence indicates that Akt phosphorylates this shared partner at serine 21, thereby ... | |
medium_convergence_06222 | EIF3B and EIF3G share multiple binding partners. One such partner is implicated by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which protein, encoded by the gene corresponding to this specific shared partner, is the target of the 'encodes' relationship? | Eukaryotic translation initiation factor 3 subunit M | Medium | convergence | {"qa_id":"medium_convergence_06222","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3B and EIF3G share multiple binding partners. One such partner is implicated by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 i... | |
medium_convergence_06224 | AKT1 and YWHAG share a common interacting partner. Evidence regarding this partner states: 'This represents phosphorylation by the serine/threonine kinase protein kinase B (PKB), since PKB constitutively associates with this partner, phosphorylates this partner on a consensus phosphorylation site, Ser159, in vitro and ... | osteopetrosis | Medium | convergence | {"qa_id":"medium_convergence_06224","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and YWHAG share a common interacting partner. Evidence regarding this partner states: 'This represents phosphorylation by the serine/threonine kinase pr... | |
medium_convergence_06225 | PHC1 and PCGF6 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Further biochemical dissection revealed that the six PCGF-RING1A/B combinations form multiple complexes through association with this entity or its homolog YAF2, which prevents the incorporation of other cano... | RING1 and YY1-binding protein | Medium | convergence | {"qa_id":"medium_convergence_06225","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PHC1 and PCGF6 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Further biochemical dissection revealed that ... | |
medium_convergence_06227 | Human polyomavirus 1 and Enterovirus A both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 3.13 and an adjusted p-value of approximately 0.023. Which disease is associated with this gene? | spondyloepimetaphyseal dysplasia, Krakow type | Medium | convergence | {"qa_id":"medium_convergence_06227","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Enterovirus A both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a... | |
medium_convergence_06228 | EGFR and ERBB2 both interact with a specific shared protein. Experimental evidence indicates that this protein coprecipitates with activated epidermal growth factor and platelet-derived growth factor (PDGF) receptors, and that phosphorylated tyrosine residues on the PDGF receptor mediate the tyrosine phosphorylation of... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_06228","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and ERBB2 both interact with a specific shared protein. Experimental evidence indicates that this protein coprecipitates with activated epidermal growth... | |
medium_convergence_06229 | HDAC1 and HIST2H3A share multiple binding partners. One shared partner is part of an affinity-purified HDAC1 corepressor complex, with evidence suggesting that MeCP1 corresponds to a fraction of this complex. Which protein is encoded by this shared partner? | Methyl-CpG-binding domain protein 2 | Medium | convergence | {"qa_id":"medium_convergence_06229","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and HIST2H3A share multiple binding partners. One shared partner is part of an affinity-purified HDAC1 corepressor complex, with evidence suggesting th... | |
medium_convergence_06230 | Human alphaherpesvirus 3 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.13 and an adjusted p-value of 0.000465. Which protein does this downregulated gene interact with? | LGALS3 | Medium | convergence | {"qa_id":"medium_convergence_06230","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports... | |
medium_convergence_06231 | CDK2 and EHMT1 both interact with a shared protein. Evidence regarding this shared protein states: 'Here we substantiate the evidence that mammalian cyclin A-Cdk2 prevents unscheduled APC reactivation during S phase by demonstrating its periodic interaction with the shared protein at the level of endogenous proteins.' ... | Fizzy-related protein homolog | Medium | convergence | {"qa_id":"medium_convergence_06231","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and EHMT1 both interact with a shared protein. Evidence regarding this shared protein states: 'Here we substantiate the evidence that mammalian cyclin A... | |
medium_convergence_06232 | CLSPN and CDC45 share multiple binding partners. One shared partner is a DNA helicase subunit whose interaction with Claspin is lost upon Cdc7 inhibition. Which protein is encoded by this shared partner? | DNA replication licensing factor MCM2 | Medium | convergence | {"qa_id":"medium_convergence_06232","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLSPN and CDC45 share multiple binding partners. One shared partner is a DNA helicase subunit whose interaction with Claspin is lost upon Cdc7 inhibition. Wh... | |
medium_convergence_06233 | PRNP and BAG6 both interact with a shared protein that is part of a ubiquitin ligase-associated multiprotein complex including Trc35, which chaperones retrotranslocated polypeptides to the proteasome to enhance ERAD efficiency. Which disease is associated with this shared protein? | premature menopause | Medium | convergence | {"qa_id":"medium_convergence_06233","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRNP and BAG6 both interact with a shared protein that is part of a ubiquitin ligase-associated multiprotein complex including Trc35, which chaperones retrot... | |
medium_convergence_06234 | STIP1 and HSP90AA1 share multiple interacting partners. One such shared partner is implicated in a context where two cochaperones, the C terminus of Hsp70-interacting protein (CHIP) and the Hsp70/Hsp90 organizer protein, were associated with a specific gene product. Which disease is connected to this shared partner thr... | congenital bilateral absence of vas deferens | Medium | convergence | {"qa_id":"medium_convergence_06234","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STIP1 and HSP90AA1 share multiple interacting partners. One such shared partner is implicated in a context where two cochaperones, the C terminus of Hsp70-in... | |
medium_convergence_06235 | GNB1 and GNB3 both interact with a shared protein entity. Evidence regarding this entity states: 'The gamma 4 is modified by a geranylgeranyl group and is capable of interacting with both beta 1 and beta 2 but not with beta 3.' Which protein is encoded by the gene corresponding to this entity? | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 | Medium | convergence | {"qa_id":"medium_convergence_06235","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNB1 and GNB3 both interact with a shared protein entity. Evidence regarding this entity states: 'The gamma 4 is modified by a geranylgeranyl group and is ca... | |
medium_convergence_06236 | PML and TP53 share multiple interacting partners. One such shared partner is described by the evidence: 'The PIAS proteins physically interact with both p53 and c-Jun.' Which disease is associated with this specific shared entity? | colon carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06236","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PML and TP53 share multiple interacting partners. One such shared partner is described by the evidence: 'The PIAS proteins physically interact with both p53 ... | |
medium_convergence_06239 | CTNNB1 and CDC42 share multiple binding partners. One such partner is described as a recently discovered calmodulin-binding protein that binds stoichiometrically to beta-catenin and regulates the association of beta-catenin with the cell-cell adhesion complex. Which cell type is this specific protein enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06239","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and CDC42 share multiple binding partners. One such partner is described as a recently discovered calmodulin-binding protein that binds stoichiometric... | |
medium_convergence_06240 | Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data for this gene in non-small cell lung adenocarcinoma cell lines (study GSE147507) reports a log2 fold change of approximately 1.52 and an adjusted p-value of appr... | Brain and acute leukemia cytoplasmic protein | Medium | convergence | {"qa_id":"medium_convergence_06240","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental dat... | |
medium_convergence_06241 | Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for this shared target in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 3.59 and an adjusted p-value of 0.0243. Which protein is encoded by this gene? | Protein TAMALIN | Medium | convergence | {"qa_id":"medium_convergence_06241","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for this shared target in renal epithelial cells (study GSE... | |
medium_convergence_06242 | IMMT and TDRKH both interact with a shared protein. Evidence indicates that TRAP1 performs a specific function by competing with this shared protein for binding to MIC60. Which protein is encoded by the gene corresponding to this shared entity? | E3 ubiquitin-protein ligase MARCHF5 | Medium | convergence | {"qa_id":"medium_convergence_06242","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IMMT and TDRKH both interact with a shared protein. Evidence indicates that TRAP1 performs a specific function by competing with this shared protein for bind... | |
medium_convergence_06243 | TRIM28 and PARP1 share multiple interacting partners. One such partner is a protein that PARP1 interacts with and PARylates at two residues within its conserved CW-type zinc finger domain. Which cell type is enriched in this specific protein? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_06243","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and PARP1 share multiple interacting partners. One such partner is a protein that PARP1 interacts with and PARylates at two residues within its conser... | |
medium_convergence_06244 | Both PPP1CB and PPP1CC interact with a shared protein entity. Experimental evidence for this interaction specifically notes that the yeast two-hybrid system was used to identify cDNAs encoding proteins interacting with the gamma 1 isoform of human protein phosphatase 1. Which protein is encoded by this shared interacti... | Protein phosphatase inhibitor 2 | Medium | convergence | {"qa_id":"medium_convergence_06244","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both PPP1CB and PPP1CC interact with a shared protein entity. Experimental evidence for this interaction specifically notes that the yeast two-hybrid system ... | |
medium_convergence_06245 | EP300 and HDAC2 both interact with a specific transcription factor. Evidence indicates that p300 markedly potentiates the binding of this transcription factor to the bcl-2 NFAT element by interacting with it in an E1A-dependent manner. Which protein is encoded by the gene corresponding to this transcription factor? | Nuclear factor of activated T-cells, cytoplasmic 1 | Medium | convergence | {"qa_id":"medium_convergence_06245","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and HDAC2 both interact with a specific transcription factor. Evidence indicates that p300 markedly potentiates the binding of this transcription facto... | |
medium_convergence_06246 | Vaccinia virus and Human respirovirus 3 both upregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 3.308 and an adjusted p-value of 1.571e-12. Which biological process is this gene involved in? | mitochondrial translation | Medium | convergence | {"qa_id":"medium_convergence_06246","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human respirovirus 3 both upregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) repor... | |
medium_convergence_06247 | NBN and RFC4 both physically interact with a common protein. Evidence indicates that this shared protein physically associates with NBS1 in vivo. Which protein is encoded by the gene corresponding to this shared interaction partner? | DNA topoisomerase 2-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06247","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NBN and RFC4 both physically interact with a common protein. Evidence indicates that this shared protein physically associates with NBS1 in vivo. Which prote... | |
medium_convergence_06248 | HUWE1 and VCP both interact with a shared protein. Evidence regarding this shared entity states: 'We clarified that [the shared protein], an essential factor in both p97 membrane fusion pathways, is phosphorylated on Threonine-760 and Serine-767 by Cdc2 at mitosis and that this phosphorylated [shared protein] does not ... | Deubiquitinating protein VCPIP1 | Medium | convergence | {"qa_id":"medium_convergence_06248","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HUWE1 and VCP both interact with a shared protein. Evidence regarding this shared entity states: 'We clarified that [the shared protein], an essential factor... | |
medium_convergence_06249 | ATG16L1 and YWHAE both interact with a shared protein. Evidence indicates that this shared protein binds to the kinase domain of a receptor-interacting serine/threonine-protein kinase and negatively regulates TLR2-mediated NF-κB activation and pro-inflammatory cytokine responses by inhibiting the interaction between TL... | Receptor-interacting serine/threonine-protein kinase 2 | Medium | convergence | {"qa_id":"medium_convergence_06249","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATG16L1 and YWHAE both interact with a shared protein. Evidence indicates that this shared protein binds to the kinase domain of a receptor-interacting serin... | |
medium_convergence_06250 | SMAD2 and SMAD3 both interact with a specific shared protein partner. Experimental evidence indicates that SMAD3 physically interacts with the HMG box domain of this partner. Which protein is encoded by the gene corresponding to this shared partner? | Lymphoid enhancer-binding factor 1 | Medium | convergence | {"qa_id":"medium_convergence_06250","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD2 and SMAD3 both interact with a specific shared protein partner. Experimental evidence indicates that SMAD3 physically interacts with the HMG box domain... | |
medium_convergence_06252 | FANCA and EIF2AK2 each interact with more than one shared protein. Evidence concerning one of these shared proteins states: 'In normal cells, HA-tagged [protein] coimmunoprecipitates with FANCA, FANCC, and FANCG but not with FANCD2.' Which protein is encoded by the gene corresponding to this shared entity? | Fanconi anemia group E protein | Medium | convergence | {"qa_id":"medium_convergence_06252","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCA and EIF2AK2 each interact with more than one shared protein. Evidence concerning one of these shared proteins states: 'In normal cells, HA-tagged [prot... | |
medium_convergence_06253 | BCAP31 and PGRMC1 share common interaction partners. One such partner is described in the following evidence: 'Here, we show that a part of the BAP31 population interacts with two components of the Sec61 preprotein translocon, Sec61beta and TRAM.' Which cell type is this interaction partner enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_06253","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BCAP31 and PGRMC1 share common interaction partners. One such partner is described in the following evidence: 'Here, we show that a part of the BAP31 populat... | |
medium_convergence_06254 | EGFR and FYN share common interaction partners. One such partner is a protein whose SH3 domain mediates direct binding to the protein encoded by SH2D1A, as demonstrated by in vitro and in vivo studies. Which protein is encoded by the gene corresponding to this shared interaction partner? | SH2 domain-containing protein 1A | Medium | convergence | {"qa_id":"medium_convergence_06254","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and FYN share common interaction partners. One such partner is a protein whose SH3 domain mediates direct binding to the protein encoded by SH2D1A, as d... | |
medium_convergence_06255 | Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.139 and an adjusted p-value of 1.632e-05. Which disease is associated with this gene? | adenoviridae infectious disease | Medium | convergence | {"qa_id":"medium_convergence_06255","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a... | |
medium_convergence_06256 | E2F1 and ESR1 share multiple interacting partners. One such partner is described by the evidence: 'All four factors of the Sp1 family are able to bind E2F-1 in co-immunoprecipitation and GST-pull down experiments.' Which disease is causally linked to this specific shared partner? | melanoma | Medium | convergence | {"qa_id":"medium_convergence_06256","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"E2F1 and ESR1 share multiple interacting partners. One such partner is described by the evidence: 'All four factors of the Sp1 family are able to bind E2F-1 ... | |
medium_convergence_06259 | Both Influenza A virus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of approximately 1.176 and an adjusted p-value of 0.01674. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06259","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of appr... | |
medium_convergence_06260 | EZH2 and ZMYND8 both interact with a shared protein. Evidence for one such shared partner states: 'We found a specific interaction between the ATRX protein and the EZH2 proteins.' Which protein product is encoded by this shared partner? | Transcriptional regulator ATRX | Medium | convergence | {"qa_id":"medium_convergence_06260","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EZH2 and ZMYND8 both interact with a shared protein. Evidence for one such shared partner states: 'We found a specific interaction between the ATRX protein a... | |
medium_convergence_06261 | EHMT2 and ESR1 share multiple interacting partners. One such partner is described in evidence stating: 'Using a yeast two-hybrid screen, we have identified an interaction between ER alpha and the proapoptotic forkhead transcription factor [shared partner].' Which protein is encoded by this specific shared partner? | Forkhead box protein O1 | Medium | convergence | {"qa_id":"medium_convergence_06261","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and ESR1 share multiple interacting partners. One such partner is described in evidence stating: 'Using a yeast two-hybrid screen, we have identified a... | |
medium_convergence_06262 | DCTN1 and CAPZA2 both interact with a specific protein. Evidence indicates that phosphorylation enhances the specific binding of p150(Glued) to the tail domain of HsEg5 in vitro, suggesting a direct interaction between these two proteins. Which gene encodes the protein identified as HsEg5 in this context? | Kinesin-like protein KIF11 | Medium | convergence | {"qa_id":"medium_convergence_06262","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCTN1 and CAPZA2 both interact with a specific protein. Evidence indicates that phosphorylation enhances the specific binding of p150(Glued) to the tail doma... | |
medium_convergence_06263 | Zaire ebolavirus and Primate bocaparvovirus 1 both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE100839) reports a log2 fold change of approximately -1.043 and an adjusted p-value of 0.009696. Which protein is encoded by this gene? | CCAAT/enhancer-binding protein beta | Medium | convergence | {"qa_id":"medium_convergence_06263","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Primate bocaparvovirus 1 both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (s... | |
medium_convergence_06264 | EPHA2 and FHL2 share common interaction partners. One such shared partner is described in the following evidence: 'We report that the LIM-only protein DRAL/FHL2, with four and a half LIM domains, can associate with alpha(3A), alpha(3B), alpha(7A), and several beta integrin subunits as shown in yeast two-hybrid assays a... | hyperthyroidism | Medium | convergence | {"qa_id":"medium_convergence_06264","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPHA2 and FHL2 share common interaction partners. One such shared partner is described in the following evidence: 'We report that the LIM-only protein DRAL/F... | |
medium_convergence_06265 | CENPK and CENPH both interact with a shared protein partner. Evidence regarding this partner states: 'We found that the MID-MHF complex consists of one histone H3-H4-like MHF heterotetramer wrapped by a single polypeptide of MID.' Which disease is associated with this shared protein partner? | systemic sclerosis | Medium | convergence | {"qa_id":"medium_convergence_06265","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPK and CENPH both interact with a shared protein partner. Evidence regarding this partner states: 'We found that the MID-MHF complex consists of one histo... | |
medium_convergence_06266 | CSNK2A1 and ERH share a common interacting partner. Experimental evidence indicates that this partner, identified as hnRNP A2, associates with both catalytic and regulatory subunits of CK2 in binding assays, an interaction that is independent of RNA presence. Which disease is linked to this specific interacting partner... | amyotrophic lateral sclerosis | Medium | convergence | {"qa_id":"medium_convergence_06266","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and ERH share a common interacting partner. Experimental evidence indicates that this partner, identified as hnRNP A2, associates with both catalytic... | |
medium_convergence_06267 | ADAM11 and ADAM22 both interact with a specific shared protein. Evidence indicates that ADAM22, a transmembrane protein associated with seizures when mutated, functions as a receptor for this shared entity. Which protein is encoded by this shared entity? | Leucine-rich glioma-inactivated protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06267","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADAM11 and ADAM22 both interact with a specific shared protein. Evidence indicates that ADAM22, a transmembrane protein associated with seizures when mutated... | |
medium_convergence_06268 | COMMD1 and DDB1 both interact with a specific protein complex component. Evidence indicates that CUL4 complexes interact with multiple WD40-repeat proteins, including a specific WD40-repeat protein. Which protein is encoded by this entity? | Denticleless protein homolog | Medium | convergence | {"qa_id":"medium_convergence_06268","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and DDB1 both interact with a specific protein complex component. Evidence indicates that CUL4 complexes interact with multiple WD40-repeat proteins, ... | |
medium_convergence_06269 | PLK1 and YWHAG share multiple interacting partners. One such shared partner is characterized by evidence stating that it responds to the HER2 signaling cascade by translocating into the nucleus following Ser273 phosphorylation, and subsequently contributes to cell mitosis regulation by binding with PLK1 to promote the ... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_06269","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PLK1 and YWHAG share multiple interacting partners. One such shared partner is characterized by evidence stating that it responds to the HER2 signaling casca... | |
medium_convergence_06270 | BMP4 and GDF5 both interact with a specific receptor. Experimental evidence indicates that BMP-4 binds to ALK-3 in MC3T3-E1 osteoblasts and human foreskin fibroblasts. Which disease is causally linked to this receptor? | CREST syndrome | Medium | convergence | {"qa_id":"medium_convergence_06270","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP4 and GDF5 both interact with a specific receptor. Experimental evidence indicates that BMP-4 binds to ALK-3 in MC3T3-E1 osteoblasts and human foreskin fi... | |
medium_convergence_06271 | PRKDC and DCLRE1C both interact with a shared protein entity. Evidence regarding this entity states: 'The DNA-dependent protein kinase (DNA-PK) controls the repair of double-stranded DNA breaks in mammalian cells. The protein kinase subunit of DNA-PK (DNA-PKcs) is targeted to DNA breaks by association with the Ku DNA-b... | alcohol abuse | Medium | convergence | {"qa_id":"medium_convergence_06271","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKDC and DCLRE1C both interact with a shared protein entity. Evidence regarding this entity states: 'The DNA-dependent protein kinase (DNA-PK) controls the ... | |
medium_convergence_06272 | MYC and SMURF1 share a common interacting partner. Evidence regarding this shared partner states: 'We determined that LMP-1, a LIM domain protein capable of inducing de novo bone formation, interacts with Smurf1 (Smad ubiquitin regulatory factor 1) and prevents ubiquitination of Smads.' Which protein is encoded by this... | PDZ and LIM domain protein 7 | Medium | convergence | {"qa_id":"medium_convergence_06272","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and SMURF1 share a common interacting partner. Evidence regarding this shared partner states: 'We determined that LMP-1, a LIM domain protein capable of ... | |
medium_convergence_06273 | Both Human betaherpesvirus 5 and Rhinovirus A are known to upregulate a specific shared gene. Experimental data from a study on retinal pigment epithelium cells (GSE120891) indicates that for one such shared target, the log2 fold change is approximately 1.96 and the adjusted p-value is 0.001077. Which cellular componen... | extracellular space | Medium | convergence | {"qa_id":"medium_convergence_06273","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human betaherpesvirus 5 and Rhinovirus A are known to upregulate a specific shared gene. Experimental data from a study on retinal pigment epithelium ce... | |
medium_convergence_06274 | SUPT16H and AKT1 both interact with a specific shared protein. Evidence indicates that Akt phosphorylates this shared protein at serine 21, thereby suppressing its methyltransferase activity by preventing its binding to histone H3. This modification leads to decreased lysine 27 trimethylation and the derepression of si... | Histone-lysine N-methyltransferase EZH2 | Medium | convergence | {"qa_id":"medium_convergence_06274","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SUPT16H and AKT1 both interact with a specific shared protein. Evidence indicates that Akt phosphorylates this shared protein at serine 21, thereby suppressi... | |
medium_convergence_06275 | Both West Nile virus and Zaire ebolavirus are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of approximately 1.205 and an adjusted p-value of 0.01096. In which cell type is this gene enriched? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06275","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Zaire ebolavirus are known to upregulate a specific shared gene. Experimental data for this gene indicates a log2 fold change of app... | |
medium_convergence_06276 | EIF3I and EIF2S2 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which protein is connected to that specific entity through the 'encodes' relationship? | Eukaryotic translation initiation factor 3 subunit M | Medium | convergence | {"qa_id":"medium_convergence_06276","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3I and EIF2S2 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Indeed, CIF-1 binds eIF-3.F and... | |
medium_convergence_06277 | SLC18A2 and STX1A both interact with a shared protein partner. Evidence regarding one such partner states: 'In the present study, we demonstrate by three independent methods that the C terminus of Munc13-1 interacts directly with a putative coiled coil domain in the N-terminal part of syntaxin.' Which protein is encode... | Protein unc-13 homolog B | Medium | convergence | {"qa_id":"medium_convergence_06277","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SLC18A2 and STX1A both interact with a shared protein partner. Evidence regarding one such partner states: 'In the present study, we demonstrate by three ind... | |
medium_convergence_06278 | BAG6 and OTOF both interact with a shared protein partner. Evidence regarding this partner states: 'Thereby, Hsp70 and Bag-6/Bat-3/Scythe were identified as novel interaction partners of this protein while interaction with Hsc70 was confirmed.' Which disease is associated with this shared protein partner? | alcohol abuse | Medium | convergence | {"qa_id":"medium_convergence_06278","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BAG6 and OTOF both interact with a shared protein partner. Evidence regarding this partner states: 'Thereby, Hsp70 and Bag-6/Bat-3/Scythe were identified as ... | |
medium_convergence_06280 | SEC61B and FZR1 share a common interaction partner. Evidence indicates that APC(Cdh1) interacts with this shared entity and targets it for ubiquitination and destruction in the cytoplasm by recognizing a conserved canonical D-box motif within it. Which protein is encoded by this shared entity? | Sentrin-specific protease 2 | Medium | convergence | {"qa_id":"medium_convergence_06280","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SEC61B and FZR1 share a common interaction partner. Evidence indicates that APC(Cdh1) interacts with this shared entity and targets it for ubiquitination and... | |
medium_convergence_06281 | CRY2 and CAND1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports that a CRY2 variant exhibited unexpected resistance to degradation via the canonical proteasomal pathway, primarily due to the loss of interactions with E3 ligases (specifically FBXL3 and this shared pa... | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_06281","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRY2 and CAND1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports that a CRY2 variant exhibited unexpecte... | |
medium_convergence_06282 | UBE2D2 and UBE2D3 each interact with more than one shared gene product. Evidence concerning one such shared entity reports: 'In vitro binding and immunoprecipitation assays demonstrated that both PJA1 and this entity are able to bind the ubiquitin-conjugating enzyme UbcH5B.' Which protein is encoded by that entity? | E3 ubiquitin-protein ligase Praja-2 | Medium | convergence | {"qa_id":"medium_convergence_06282","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBE2D2 and UBE2D3 each interact with more than one shared gene product. Evidence concerning one such shared entity reports: 'In vitro binding and immunopreci... | |
medium_convergence_06283 | RBCK1 and IKBKB both interact with a shared protein partner. Evidence regarding this partner indicates that it forms part of the linear ubiquitin chain assembly complex (LUBAC) and is involved in ubiquitylating NEMO. Which protein is encoded by the gene corresponding to this shared partner? | E3 ubiquitin-protein ligase RNF31 | Medium | convergence | {"qa_id":"medium_convergence_06283","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RBCK1 and IKBKB both interact with a shared protein partner. Evidence regarding this partner indicates that it forms part of the linear ubiquitin chain assem... | |
medium_convergence_06284 | TOPBP1 and HDAC1 share common interaction partners. One such shared partner is functionally analogous to the budding yeast protein Fun30, as both are cell cycle-regulated through interaction with the DSB-localized scaffold protein Dpb11 (in yeast) or TOPBP1 (in humans). Which protein corresponds to this human entity? | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 | Medium | convergence | {"qa_id":"medium_convergence_06284","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and HDAC1 share common interaction partners. One such shared partner is functionally analogous to the budding yeast protein Fun30, as both are cell cy... | |
medium_convergence_06286 | Vaccinia virus and Human alphaherpesvirus 1 both downregulate a specific shared gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -2.78 and an adjusted p-value of approximately 0.013. Which disease is associated with this gene as a ... | prostate cancer | Medium | convergence | {"qa_id":"medium_convergence_06286","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human alphaherpesvirus 1 both downregulate a specific shared gene. Experimental data for this gene in a cervical adenocarcinoma cell line ... | |
medium_convergence_06287 | MYL3 and TNNC1 both interact with a specific protein partner. Experimental evidence regarding this partner states: 'On addition of troponin C to each of the CNBr-cleavage peptides in turn, perturbations of side chains were noted only for peptides CN5 (residues 1-21) and CN4 (residues 96-116).' Which protein is encoded ... | Troponin I, fast skeletal muscle | Medium | convergence | {"qa_id":"medium_convergence_06287","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYL3 and TNNC1 both interact with a specific protein partner. Experimental evidence regarding this partner states: 'On addition of troponin C to each of the ... | |
medium_convergence_06288 | The olfactory bulb layer and the white matter lamina of the neuraxis are both subtypes of a specific anatomical entity. Evidence regarding this shared entity cites a missing definition for term UBERON:0004001. Which anatomical structure is this shared entity a part of? | nervous system | Medium | convergence | {"qa_id":"medium_convergence_06288","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The olfactory bulb layer and the white matter lamina of the neuraxis are both subtypes of a specific anatomical entity. Evidence regarding this shared entity... | |
medium_convergence_06290 | PHB2 and EP300 both interact with a specific shared protein. Evidence indicates that this shared protein interacted with ERalpha and CREB-binding protein/p300 to form a weak activating transcriptional complex that competed for binding to Sp1 sites with the ERalpha transcriptional complex, slightly attenuating BRCA2 tra... | Estrogen receptor beta | Medium | convergence | {"qa_id":"medium_convergence_06290","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PHB2 and EP300 both interact with a specific shared protein. Evidence indicates that this shared protein interacted with ERalpha and CREB-binding protein/p30... | |
medium_convergence_06291 | PRDX4 and MYC share common protein interaction partners. One such shared partner is described in the following evidence: 'Here, we describe a new human thioredoxin peroxidase, antioxidant enzyme AOE372, identified by virtue of its protein-protein interaction with the product of a proliferation association gene, pag, wh... | Peroxiredoxin-1 | Medium | convergence | {"qa_id":"medium_convergence_06291","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRDX4 and MYC share common protein interaction partners. One such shared partner is described in the following evidence: 'Here, we describe a new human thior... | |
medium_convergence_06292 | DDIT3 and MYC share multiple interacting partners. One such shared partner is a mammalian tribbles homolog that functions as a repressor of CHOP, interacts with CHOP via its N-terminal portion, and significantly blocks the association of p300 with CHOP. Which protein is encoded by the gene corresponding to this shared ... | Tribbles homolog 3 | Medium | convergence | {"qa_id":"medium_convergence_06292","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDIT3 and MYC share multiple interacting partners. One such shared partner is a mammalian tribbles homolog that functions as a repressor of CHOP, interacts w... | |
medium_convergence_06293 | MDM2 and NPM1 both interact with a shared gene product. Evidence indicates that in glioma cells, this shared gene product directly interacts with MDM2, leading to MDM2-p53-mediated cell proliferation and apoptosis. Which cell type is enriched for this shared gene product? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_06293","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and NPM1 both interact with a shared gene product. Evidence indicates that in glioma cells, this shared gene product directly interacts with MDM2, leadi... | |
medium_convergence_06294 | Morphine and Brompheniramine both interact with a specific third drug. Evidence regarding this interaction notes that the ventilatory-depressant effects of agonists from the two classes were less than additive. Which disease is this third drug indicated for? | insomnia | Medium | convergence | {"qa_id":"medium_convergence_06294","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Morphine and Brompheniramine both interact with a specific third drug. Evidence regarding this interaction notes that the ventilatory-depressant effects of a... | |
medium_convergence_06295 | FANCE and ATR each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In normal cells, HA-tagged FANCE protein coimmunoprecipitates with FANCA, FANCC, and this shared entity but not with FANCD2.' Which protein is encoded by this shared entity? | Fanconi anemia group G protein | Medium | convergence | {"qa_id":"medium_convergence_06295","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCE and ATR each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In normal cells, HA-tagged FANCE protein coimm... | |
medium_convergence_06296 | Human alphaherpesvirus 1 and Cardiovirus A both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately -1.195 and an adjusted p-value of 0.01947. Which protein is encoded by this gene? | Succinyl-CoA:glutarate CoA-transferase | Medium | convergence | {"qa_id":"medium_convergence_06296","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Cardiovirus A both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114... | |
medium_convergence_06299 | NUP107 and NUP153 both interact with a shared protein. Evidence for this shared protein states: 'We have also examined interactions between this protein and the NPC and found specific two-hybrid interactions between this protein and several well-defined components of the NPC, as well as coimmunoprecipitation of this pr... | nucleocytoplasmic transport | Medium | convergence | {"qa_id":"medium_convergence_06299","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUP107 and NUP153 both interact with a shared protein. Evidence for this shared protein states: 'We have also examined interactions between this protein and ... | |
medium_convergence_06300 | BRIP1 and ATRIP both interact with a common protein partner. Evidence indicates that this shared partner is directly inhibited in its exonuclease activity by FANCJ. Which protein is encoded by this shared partner? | Double-strand break repair protein MRE11 | Medium | convergence | {"qa_id":"medium_convergence_06300","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRIP1 and ATRIP both interact with a common protein partner. Evidence indicates that this shared partner is directly inhibited in its exonuclease activity by... | |
medium_convergence_06301 | The biological processes 'regulation of branching involved in mammary gland duct morphogenesis' and 'regulation of branching involved in ureteric bud morphogenesis' share a common parent process. Evidence for this shared entity states: 'Any process that modulates the rate, frequency, or extent of branching involved in ... | morphogenesis of a branching structure | Medium | convergence | {"qa_id":"medium_convergence_06301","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'regulation of branching involved in mammary gland duct morphogenesis' and 'regulation of branching involved in ureteric bud morphog... | |
medium_convergence_06302 | G3BP1 and FMR1 share multiple interacting partners. One such shared partner is a protein that interacts with FMRP via a novel interaction motif located in its N-terminal region. Which gene encodes this specific shared interacting protein? | FMR1-interacting protein NUFIP2 | Medium | convergence | {"qa_id":"medium_convergence_06302","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"G3BP1 and FMR1 share multiple interacting partners. One such shared partner is a protein that interacts with FMRP via a novel interaction motif located in it... | |
medium_convergence_06304 | CHD4 and PARP1 share a common interacting partner. Evidence indicates that this partner, along with DNMTs and HDAC1, forms part of the NuRD complex and physically interacts to maintain the silencing of hypermethylated tumor suppressor gene promoters. Which disease is associated with this shared partner through genomic ... | Ogden syndrome | Medium | convergence | {"qa_id":"medium_convergence_06304","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and PARP1 share a common interacting partner. Evidence indicates that this partner, along with DNMTs and HDAC1, forms part of the NuRD complex and physi... | |
medium_convergence_06305 | AKT1 and EZH2 share common interaction partners. One such shared partner is characterized by evidence stating: 'Further studies revealed that AKT1 protein interacts with this partner, and AKT1 directly phosphorylates this partner via the site Thr-210.' Which disease is associated with this specific shared partner throu... | gastric cancer | Medium | convergence | {"qa_id":"medium_convergence_06305","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and EZH2 share common interaction partners. One such shared partner is characterized by evidence stating: 'Further studies revealed that AKT1 protein in... | |
medium_convergence_06306 | AXIN1 and BTRC share multiple binding partners. One such shared partner is described in evidence stating: 'We also found that both [Casein kinase I alpha] and CKIepsilon interacted with Axin, whereas CKIIalpha did not bind to Axin and had no effect on Axin-mediated JNK activity even though CKIIalpha has also been sugge... | Casein kinase I isoform alpha | Medium | convergence | {"qa_id":"medium_convergence_06306","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AXIN1 and BTRC share multiple binding partners. One such shared partner is described in evidence stating: 'We also found that both [Casein kinase I alpha] an... | |
medium_convergence_06307 | CAND1 and CUL3 each interact with multiple shared partners. One such partner is part of a novel CUL3 RING ubiquitin ligase complex that contains substrate adaptors KBTBD6 and this partner, mediating the ubiquitylation and proteasomal degradation of TIAM1. Which protein is encoded by this partner? | Kelch repeat and BTB domain-containing protein 7 | Medium | convergence | {"qa_id":"medium_convergence_06307","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAND1 and CUL3 each interact with multiple shared partners. One such partner is part of a novel CUL3 RING ubiquitin ligase complex that contains substrate ad... | |
medium_convergence_06309 | TP53 and UBE2D2 share a common interacting partner. One such partner is described as a p53-interacting protein called Hades, an E3 ligase that interacts with p53 in the mitochondria. Which protein is encoded by this specific shared partner? | Mitochondrial ubiquitin ligase activator of NFKB 1 | Medium | convergence | {"qa_id":"medium_convergence_06309","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TP53 and UBE2D2 share a common interacting partner. One such partner is described as a p53-interacting protein called Hades, an E3 ligase that interacts with... | |
medium_convergence_06311 | CCL19 and CCL21 are both involved in a shared biological process. Evidence indicates that stimulated human neutrophils migrate in response to the CCR7 ligands CCL19 and CCL21. Which cell type is connected to this shared biological process via the 'enabled by cell' relationship? | epidermal keratinocyte | Medium | convergence | {"qa_id":"medium_convergence_06311","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCL19 and CCL21 are both involved in a shared biological process. Evidence indicates that stimulated human neutrophils migrate in response to the CCR7 ligand... | |
medium_convergence_06312 | MDM2 and PTEN share a common interacting partner. Evidence indicates that a ribosomal protein interacts with this shared entity at its central acidic domain, thereby suppressing the entity-mediated ubiquitination of p53, which leads to p53 activation and cell cycle arrest. Which disease is associated with this shared e... | gastric cancer | Medium | convergence | {"qa_id":"medium_convergence_06312","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and PTEN share a common interacting partner. Evidence indicates that a ribosomal protein interacts with this shared entity at its central acidic domain,... | |
medium_convergence_06313 | BAZ2A and RBBP4 both interact with a shared protein partner. Evidence indicates that p33(ING1b) associates with Sin3, SAP30, HDAC1, RbAp48, and other proteins to form large protein complexes, whereas p24(ING1c) does not. Which protein, connected to this shared partner via an 'encodes' relationship, is best supported by... | Paired amphipathic helix protein Sin3a | Medium | convergence | {"qa_id":"medium_convergence_06313","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BAZ2A and RBBP4 both interact with a shared protein partner. Evidence indicates that p33(ING1b) associates with Sin3, SAP30, HDAC1, RbAp48, and other protein... | |
medium_convergence_06314 | PARP1 and BRD4 both interact with a specific shared protein. Experimental evidence indicates that Parp2 interacts significantly with this protein (identified as a transition chaperone) and with TP2, whereas Parp1 binds weakly to it. Which protein is encoded by the gene corresponding to this shared entity? | Heat shock-related 70 kDa protein 2 | Medium | convergence | {"qa_id":"medium_convergence_06314","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and BRD4 both interact with a specific shared protein. Experimental evidence indicates that Parp2 interacts significantly with this protein (identified... | |
medium_convergence_06315 | NUP35 and KPNB1 both interact with a specific nuclear transport factor. Evidence regarding this factor states: 'The import reaction is terminated by the direct binding of nuclear [Factor]GTP to importin-beta which dissociates the importin heterodimer.' Which protein is encoded by the gene corresponding to this factor? | GTP-binding nuclear protein Ran | Medium | convergence | {"qa_id":"medium_convergence_06315","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUP35 and KPNB1 both interact with a specific nuclear transport factor. Evidence regarding this factor states: 'The import reaction is terminated by the dire... | |
medium_convergence_06316 | PRDX3 and PINK1 are both involved in more than one shared biological process. Evidence concerning one of these shared processes states: 'Results using mitochondria-specific fluorescent probes demonstrate that PRDX3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells... | regulation of membrane potential | Medium | convergence | {"qa_id":"medium_convergence_06316","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRDX3 and PINK1 are both involved in more than one shared biological process. Evidence concerning one of these shared processes states: 'Results using mitoch... | |
medium_convergence_06317 | BIRC3 and XIAP both interact with a shared protein. Evidence regarding this shared entity states: 'In this study, we found that XIAP, cIAP1 and cIAP2 not only directly bind to RIP1 and [REDACTED] but also to RIP3 and RIP4.' Which protein is connected to that entity through the 'encodes' relationship? | Receptor-interacting serine/threonine-protein kinase 2 | Medium | convergence | {"qa_id":"medium_convergence_06317","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC3 and XIAP both interact with a shared protein. Evidence regarding this shared entity states: 'In this study, we found that XIAP, cIAP1 and cIAP2 not onl... | |
medium_convergence_06318 | Carteolol and Pindolol both interact with a specific shared drug. Evidence indicates that this shared drug, along with Carbachol, reduced the maximal relaxation to fenoterol and abolished relaxations to the partial agonist Pindolol. Which drug interacts with this shared entity? | Amifampridine | Medium | convergence | {"qa_id":"medium_convergence_06318","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Carteolol and Pindolol both interact with a specific shared drug. Evidence indicates that this shared drug, along with Carbachol, reduced the maximal relaxat... | |
medium_convergence_06319 | Both Human polyomavirus 1 and Enterovirus A are known to upregulate a specific host gene. Experimental data from a study on renal epithelial cells (GSE135833) indicates that this gene exhibits a log2 fold change of approximately 1.499 and an adjusted p-value of 0.003227. In which cellular component is the protein produ... | chromatin | Medium | convergence | {"qa_id":"medium_convergence_06319","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human polyomavirus 1 and Enterovirus A are known to upregulate a specific host gene. Experimental data from a study on renal epithelial cells (GSE135833... | |
medium_convergence_06320 | Enterovirus A and Zaire ebolavirus both downregulate a specific gene. In a study of rhabdomyosarcoma cells (GSE103308), this gene exhibited a log2 fold change of -1.683 and an adjusted p-value of 0.0004964. Which protein does this gene product bind to? | PPARG | Medium | convergence | {"qa_id":"medium_convergence_06320","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Zaire ebolavirus both downregulate a specific gene. In a study of rhabdomyosarcoma cells (GSE103308), this gene exhibited a log2 fold chang... | |
medium_convergence_06322 | Both the androgen receptor (AR) and the nuclear factor I/C (NFIC) share interaction partners. One such shared partner is a subunit of the SWI/SNF chromatin remodeling complex, identified as a protein encoded by the SMARCD1 gene, which has been shown to display hormone-dependent interactions with AR via its FxxFF motif.... | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 | Medium | convergence | {"qa_id":"medium_convergence_06322","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the androgen receptor (AR) and the nuclear factor I/C (NFIC) share interaction partners. One such shared partner is a subunit of the SWI/SNF chromatin r... |
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