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medium_convergence_06093 | SEC24A and SCAP both interact with a shared protein. Evidence indicates that this shared protein forms a complex with SREBP-2, as demonstrated by co-immunoprecipitation experiments where the complex can be precipitated using antibodies against either component. Which protein is encoded by the gene corresponding to this... | Sterol regulatory element-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_06093","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SEC24A and SCAP both interact with a shared protein. Evidence indicates that this shared protein forms a complex with SREBP-2, as demonstrated by co-immunopr... | |
medium_convergence_06094 | EEF2 and ESR1 share multiple interacting partners. One such partner is implicated in a mechanism where GREB1 catalyzes the O-GlcNAcylation of ERα at residues T553/S554, thereby stabilizing the ERα protein by inhibiting its association with a specific ubiquitin ligase. Which protein is encoded by the gene corresponding ... | E3 ubiquitin-protein ligase ZNF598 | Medium | convergence | {"qa_id":"medium_convergence_06094","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EEF2 and ESR1 share multiple interacting partners. One such partner is implicated in a mechanism where GREB1 catalyzes the O-GlcNAcylation of ERα at residues... | |
medium_convergence_06095 | ESCO2 and L3MBTL1 both interact with a specific protein component of the MCM complex. Experimental evidence indicates that ESCO2, but not ESCO1, interacts with the MCM complex through a unique ESCO2 domain. Which protein, encoded by the gene connected to this shared interaction partner, is the subject of this specific ... | DNA replication licensing factor MCM4 | Medium | convergence | {"qa_id":"medium_convergence_06095","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESCO2 and L3MBTL1 both interact with a specific protein component of the MCM complex. Experimental evidence indicates that ESCO2, but not ESCO1, interacts wi... | |
medium_convergence_06096 | BARD1 and BRCA1 both interact with a specific shared protein partner. Experimental evidence indicates that the 97-kDa full-length form of BARD1 coimmunoprecipitates with BRCA1, whereas the 82-kDa BARD1beta isoform coimmunoprecipitates with Aurora B and this shared partner. Which protein is encoded by the gene correspon... | Breast cancer type 2 susceptibility protein | Medium | convergence | {"qa_id":"medium_convergence_06096","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BARD1 and BRCA1 both interact with a specific shared protein partner. Experimental evidence indicates that the 97-kDa full-length form of BARD1 coimmunopreci... | |
medium_convergence_06097 | CREBBP and CTNNB1 share a common interaction partner. Evidence regarding this partner states: 'We show that DAF-16 and [REDACTED] can interact with both the KIX and E1A/SRC interaction domains of p300/CBP, as well as the steroid receptor coactivator (SRC).' Which protein is encoded by this shared interaction partner? | Forkhead box protein O1 | Medium | convergence | {"qa_id":"medium_convergence_06097","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and CTNNB1 share a common interaction partner. Evidence regarding this partner states: 'We show that DAF-16 and [REDACTED] can interact with both the ... | |
medium_convergence_06098 | XRCC6 and MDM2 both interact with a specific protein. Evidence indicates that for this protein, the Ku70 subunit specifically interacts with its N-terminus (amino acids 1-368), while the Ku80 subunit interacts with its C-terminus (amino acids 940-1432). Which protein is this? | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | Medium | convergence | {"qa_id":"medium_convergence_06098","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"XRCC6 and MDM2 both interact with a specific protein. Evidence indicates that for this protein, the Ku70 subunit specifically interacts with its N-terminus (... | |
medium_convergence_06099 | ARL1 and COG1 share a common binding partner. Evidence indicates that the GTP-bound form of this shared partner interacts with the GRIP domains of Golgin-97 and a Golgin protein encoded by GOLGA4, a process dependent on conserved residues within the GRIP domains that are critical for Golgi targeting. Which disease is a... | lymphoid leukemia | Medium | convergence | {"qa_id":"medium_convergence_06099","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARL1 and COG1 share a common binding partner. Evidence indicates that the GTP-bound form of this shared partner interacts with the GRIP domains of Golgin-97 ... | |
medium_convergence_06100 | BRD8 and MORF4L1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Yeast two-hybrid screening and subsequent immunoprecipitation analysis identified bromodomain containing 8 (BRD8) as an [entity]-interacting protein.' Which disease is associated with that entity? | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06100","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD8 and MORF4L1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Yeast two-hybrid screening and subsequent i... | |
medium_convergence_06101 | GRIN1 and GRIN2B each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Immunoprecipitation experiments with an anti-NR1 antibody demonstrated that the majority of NR3A is associated with NR1 in postnatal day 10 rat cortex (80 +/- 8%), decreasing by half (38 +/- 4%... | response to ethanol | Medium | convergence | {"qa_id":"medium_convergence_06101","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRIN1 and GRIN2B each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Immunoprecipitation experiment... | |
medium_convergence_06102 | Both Vaccinia virus and Rhinovirus A are reported to downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of -4.597 and an adjusted p-value of 0.0401. Which protein is encoded by this gene? | Transcription factor EC | Medium | convergence | {"qa_id":"medium_convergence_06102","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Rhinovirus A are reported to downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (st... | |
medium_convergence_06103 | IL23R and CARD9 are both involved in more than one shared biological process. Evidence indicates that IL-23, an IL-12p40/p19 heterodimeric protein, binds to IL-12Rbeta1/IL-23R receptor complexes. Which biological process, connected to this entity, is defined by the relation 'positively regulates'? | interleukin-17 production | Medium | convergence | {"qa_id":"medium_convergence_06103","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL23R and CARD9 are both involved in more than one shared biological process. Evidence indicates that IL-23, an IL-12p40/p19 heterodimeric protein, binds to ... | |
medium_convergence_06106 | PPP2CA and PPP2R1A each interact with more than one shared gene product. Evidence concerning one of these shared entities reports that the STRIPAK complex contains the PP2A catalytic (PP2Ac) and scaffolding (PP2A A) subunits, the striatins (PP2A regulatory B''' subunits), the striatin-associated protein Mob3, the novel... | cervical cancer | Medium | convergence | {"qa_id":"medium_convergence_06106","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP2CA and PPP2R1A each interact with more than one shared gene product. Evidence concerning one of these shared entities reports that the STRIPAK complex co... | |
medium_convergence_06107 | RAD51 and BRCA2 both interact with a shared protein partner. Experimental evidence involving nickel-nitrilotriacetic acid pull-down assays indicates that this partner forms a highly stable heterodimer with Rad51C, while interacting only weakly with Rad51. Which protein is encoded by the gene corresponding to this share... | DNA repair protein RAD51 homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_06107","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD51 and BRCA2 both interact with a shared protein partner. Experimental evidence involving nickel-nitrilotriacetic acid pull-down assays indicates that thi... | |
medium_convergence_06108 | Both Enterovirus A and Cardiovirus A are associated with the upregulation of a specific gene in rhabdomyosarcoma cells (study GSE103308). For one such shared target, the reported log2 fold change is approximately 1.187 and the adjusted p-value is 0.002777. Which protein is encoded by this gene? | UPF0739 protein C1orf74 | Medium | convergence | {"qa_id":"medium_convergence_06108","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Enterovirus A and Cardiovirus A are associated with the upregulation of a specific gene in rhabdomyosarcoma cells (study GSE103308). For one such shared... | |
medium_convergence_06110 | HSPA8 and HSP90AA1 share interaction partners. One such partner is identified in evidence stating: 'Thereby, Hsp70 and Bag-6/Bat-3/Scythe were identified as novel [SGTA] interaction partners while interaction with Hsc70 was confirmed.' Which disease is associated with this specific shared partner? | alcohol abuse | Medium | convergence | {"qa_id":"medium_convergence_06110","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA8 and HSP90AA1 share interaction partners. One such partner is identified in evidence stating: 'Thereby, Hsp70 and Bag-6/Bat-3/Scythe were identified as ... | |
medium_convergence_06111 | Both Measles morbillivirus and Influenza A virus have been shown to downregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) reports a log2 fold change of -1.726 and an adjusted p-value of 0.0256. What molecular function is enabled by this gene? | lipid transporter activity | Medium | convergence | {"qa_id":"medium_convergence_06111","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus have been shown to downregulate a specific gene. Experimental data for this gene in pleural mesothelioma cel... | |
medium_convergence_06112 | Human alphaherpesvirus 1 and Zaire ebolavirus both downregulate a specific host gene. Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that this gene exhibits a log2 fold change of -1.312 and an adjusted p-value of 0.002787. Which protein is encoded by this gene? | Dual specificity protein phosphatase 10 | Medium | convergence | {"qa_id":"medium_convergence_06112","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Zaire ebolavirus both downregulate a specific host gene. Experimental data from a monocytic leukemia cell line (study GSE114966)... | |
medium_convergence_06113 | MYC and STAU1 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with the APC/C co-activators Cdh1 and itself via its first 88 N-terminal amino acids. Which protein is encoded by this shared entity? | Cell division cycle protein 20 homolog | Medium | convergence | {"qa_id":"medium_convergence_06113","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and STAU1 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with the APC/C co-activators Cdh1 and itsel... | |
medium_convergence_06114 | TRAF6 and SQSTM1 share a common interacting partner. Evidence regarding one such partner states: 'We report the identification of a TRAF-interacting protein, T6BP, that specifically associates with TRAF6.' Which protein is encoded by this specific interacting partner? | Tax1-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06114","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRAF6 and SQSTM1 share a common interacting partner. Evidence regarding one such partner states: 'We report the identification of a TRAF-interacting protein,... | |
medium_convergence_06115 | CTNNB1 and VIRMA share common interacting partners. One such shared partner was found to interact with β-catenin, as detected by an immuno-precipitation assay. Which protein is encoded by this shared interacting partner? | E3 ubiquitin-protein ligase UBR5 | Medium | convergence | {"qa_id":"medium_convergence_06115","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and VIRMA share common interacting partners. One such shared partner was found to interact with β-catenin, as detected by an immuno-precipitation assa... | |
medium_convergence_06116 | ITK and GRAP2 both interact with a shared protein. Evidence regarding one such shared protein states: 'Third, the Itk Src homology (SH3) 3 and SH2 domains interact cooperatively with Syk-phosphorylated [shared protein].' Which protein is encoded by the gene corresponding to this shared entity? | Lymphocyte cytosolic protein 2 | Medium | convergence | {"qa_id":"medium_convergence_06116","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ITK and GRAP2 both interact with a shared protein. Evidence regarding one such shared protein states: 'Third, the Itk Src homology (SH3) 3 and SH2 domains in... | |
medium_convergence_06117 | YAP1 and EP300 share multiple interacting partners. One such partner is described in experimental evidence stating: 'In co-immunoprecipitation assays, we discover that this protein physically associated with YAP/TAZ and furthermore disrupts the interaction between YAP and β-TrCP E3 ubiquitin ligase, which promotes YAP ... | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06117","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and EP300 share multiple interacting partners. One such partner is described in experimental evidence stating: 'In co-immunoprecipitation assays, we dis... | |
medium_convergence_06118 | PARP1 and DDB2 share a common interacting partner. Evidence regarding this shared partner states: 'Association with endogenous [protein encoded by BANF1] was independently validated by co-immunoprecipitation from HeLa cells for seven candidates including Requiem, poly(ADP-ribose) polymerase 1 (PARP1), retinoblastoma bi... | Barrier-to-autointegration factor | Medium | convergence | {"qa_id":"medium_convergence_06118","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and DDB2 share a common interacting partner. Evidence regarding this shared partner states: 'Association with endogenous [protein encoded by BANF1] was... | |
medium_convergence_06119 | Human alphaherpesvirus 3 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of -1.123 and an adjusted p-value of 2.084e-06. Which biological process is this gene involved in? | ceramide metabolic process | Medium | convergence | {"qa_id":"medium_convergence_06119","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 3 and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a... | |
medium_convergence_06120 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of 2.471 and an adjusted p-value of 0.008025. Which disease is associated with this gene through genomic alterations? | glioma | Medium | convergence | {"qa_id":"medium_convergence_06120","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (stud... | |
medium_convergence_06121 | KHDRBS1 and FGFR1 share multiple interacting partners. One such partner is supported by evidence stating: 'Co-immunoprecipitation studies revealed that a specific tyrosine kinase directly associated with FGFR-1beta.' Which protein is encoded by this specific interacting partner? | Tyrosine-protein kinase Yes | Medium | convergence | {"qa_id":"medium_convergence_06121","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KHDRBS1 and FGFR1 share multiple interacting partners. One such partner is supported by evidence stating: 'Co-immunoprecipitation studies revealed that a spe... | |
medium_convergence_06122 | MAPK14 and MAPK1 both interact with a shared protein entity. Evidence regarding this entity states: 'We report the physical and functional association of ERK1/2 with the PTP-SL and [REDACTED] protein tyrosine phosphatases (PTPs).' Which protein is encoded by this shared entity? | Tyrosine-protein phosphatase non-receptor type 5 | Medium | convergence | {"qa_id":"medium_convergence_06122","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK14 and MAPK1 both interact with a shared protein entity. Evidence regarding this entity states: 'We report the physical and functional association of ERK... | |
medium_convergence_06123 | Both pineal gland development and pituitary gland development are sub-processes of a shared biological process. Evidence regarding one such shared process describes the progression of the pineal gland from its initial formation to its mature state, noting that the pineal gland is an endocrine gland secreting melatonin ... | endocrine system | Medium | convergence | {"qa_id":"medium_convergence_06123","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both pineal gland development and pituitary gland development are sub-processes of a shared biological process. Evidence regarding one such shared process de... | |
medium_convergence_06124 | DNM2 and HSP90AA1 both interact with a shared protein target. Experimental evidence indicates that coimmunoprecipitation of Hsp90 with an antibody against this target reveals a Hsp90-target complex in endothelial cells under basal conditions, which increases following BK stimulation. Which protein is encoded by this sh... | Nitric oxide synthase 3 | Medium | convergence | {"qa_id":"medium_convergence_06124","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNM2 and HSP90AA1 both interact with a shared protein target. Experimental evidence indicates that coimmunoprecipitation of Hsp90 with an antibody against th... | |
medium_convergence_06125 | MAFF and MAFG both interact with a shared protein partner. Evidence regarding one such partner states: 'We show here that the [transcription factor] protein interacts to form heterodimers with small Maf proteins, previously shown to dimerize with p45 NF-E2, ECH and Fos.' Which cell type is enriched in the gene encoding... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06125","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAFF and MAFG both interact with a shared protein partner. Evidence regarding one such partner states: 'We show here that the [transcription factor] protein ... | |
medium_convergence_06127 | CTBP2 and ESRRG both interact with a specific shared protein. Evidence regarding this shared protein states: 'We have defined the interaction of both CtBP1 and CtBP2 with a nuclear receptor co-repressor and delineated two motifs (PIDLS and PINLS) differentially required for in vitro interaction.' Which protein is encod... | Nuclear receptor-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06127","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP2 and ESRRG both interact with a specific shared protein. Evidence regarding this shared protein states: 'We have defined the interaction of both CtBP1 a... | |
medium_convergence_06128 | PRKN (PARK2) and MARCH5 share a common interacting partner. Evidence indicates that PD-causing PARK2 mutations disrupt the molecular interaction between PARK2 and specific TOMM subunits, specifically identifying the surface receptor, the shared entity, and the channel protein TOMM40. Which protein is encoded by this sh... | Mitochondrial import receptor subunit TOM70 | Medium | convergence | {"qa_id":"medium_convergence_06128","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN (PARK2) and MARCH5 share a common interacting partner. Evidence indicates that PD-causing PARK2 mutations disrupt the molecular interaction between PARK... | |
medium_convergence_06129 | STX1A and STX7 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Both in vitro and in vivo binding studies showed that endobrevin binds to syntaxin 1.' Which protein is encoded by that entity? | Vesicle-associated membrane protein 8 | Medium | convergence | {"qa_id":"medium_convergence_06129","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STX1A and STX7 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Both in vitro and in vivo binding studie... | |
medium_convergence_06130 | Human polyomavirus 1 and Measles morbillivirus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 2.099 and an adjusted p-value of approximately 0.0317. Which protein is encoded by this gene? | SEC14-like protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06130","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Measles morbillivirus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) r... | |
medium_convergence_06131 | ERCC5 and GTF2H1 share multiple protein interaction partners. One such shared partner is described by the evidence: 'We show that these two subunits physically interact and map domains involved in the interface.' Which protein is encoded by the gene corresponding to this shared interaction partner? | General transcription factor IIH subunit 3 | Medium | convergence | {"qa_id":"medium_convergence_06131","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC5 and GTF2H1 share multiple protein interaction partners. One such shared partner is described by the evidence: 'We show that these two subunits physical... | |
medium_convergence_06133 | RMI2 and NBN share a common binding partner. Evidence indicates that this shared partner physically associates with NBS1 in vivo. Which protein is encoded by this shared partner? | DNA topoisomerase 2-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06133","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RMI2 and NBN share a common binding partner. Evidence indicates that this shared partner physically associates with NBS1 in vivo. Which protein is encoded by... | |
medium_convergence_06134 | Both KRAS and SNCA interact with a specific shared protein. Experimental evidence confirms a direct interaction between α-synuclein and this shared protein via GST pull-down and co-immunoprecipitation assays. Which protein product is encoded by this shared gene? | Spectrin beta chain, non-erythrocytic 1 | Medium | convergence | {"qa_id":"medium_convergence_06134","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both KRAS and SNCA interact with a specific shared protein. Experimental evidence confirms a direct interaction between α-synuclein and this shared protein v... | |
medium_convergence_06136 | BUB1 and AURKB both interact with a shared protein. Evidence regarding this shared entity states: 'Here we report the identification of Dasra A and Dasra B, two new components of the vertebrate chromosomal passenger complex containing Incenp, Survivin, and the kinase Aurora B, and demonstrate that this complex is requi... | Borealin | Medium | convergence | {"qa_id":"medium_convergence_06136","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BUB1 and AURKB both interact with a shared protein. Evidence regarding this shared entity states: 'Here we report the identification of Dasra A and Dasra B, ... | |
medium_convergence_06137 | CHEK1 and EP300 both interact with a specific protein component of the heterohexamic minichromosome maintenance (MCM) complex, as identified by mass spectrometry. Which protein is encoded by this shared interacting partner? | DNA replication licensing factor MCM6 | Medium | convergence | {"qa_id":"medium_convergence_06137","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and EP300 both interact with a specific protein component of the heterohexamic minichromosome maintenance (MCM) complex, as identified by mass spectrom... | |
medium_convergence_06138 | TRIM28 and EHMT2 both interact with a shared protein. Evidence indicates that this shared protein associates with transcriptional repressors including KAP1, histone deacetylases HDAC1/2, and the histone methyltransferase G9a/GLP, and it modulates the interaction of HDAC1 and KAP1 with heterochromatin. Which cell type i... | basophil | Medium | convergence | {"qa_id":"medium_convergence_06138","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and EHMT2 both interact with a shared protein. Evidence indicates that this shared protein associates with transcriptional repressors including KAP1, ... | |
medium_convergence_06139 | Estradiol and Ethinylestradiol both interact with a specific drug. Evidence regarding this drug indicates that, in a comparison with Letrozole, it resulted in higher testosterone levels and lower estradiol levels than Letrozole. Which disease is this drug indicated for? | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_06139","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Estradiol and Ethinylestradiol both interact with a specific drug. Evidence regarding this drug indicates that, in a comparison with Letrozole, it resulted i... | |
medium_convergence_06140 | DOK1 and GRAP2 both interact with a specific shared protein. Evidence regarding this shared protein states: 'Here, we report complex formation between endogenous Dok1 and the SH2 domain-containing phosphatidylinositol polyphosphate 5-phosphatase [shared protein] in hematopoietic cells expressing Bcr-Abl.' Which cellula... | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_06140","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DOK1 and GRAP2 both interact with a specific shared protein. Evidence regarding this shared protein states: 'Here, we report complex formation between endoge... | |
medium_convergence_06143 | GRB2 and IL2RA share a common binding partner. Evidence regarding this shared partner states: 'In this report we show that in response to insulin, the shared partner forms a stable complex with two tyrosine-phosphorylated proteins.' Which protein is encoded by this shared binding partner? | Insulin receptor substrate 1 | Medium | convergence | {"qa_id":"medium_convergence_06143","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and IL2RA share a common binding partner. Evidence regarding this shared partner states: 'In this report we show that in response to insulin, the shared... | |
medium_convergence_06145 | CPLX1 and PPFIA1 share common binding partners. One of these shared partners is described as binding in an antiparallel alpha-helical conformation to the groove between the synaptobrevin and syntaxin helices. Which disease is associated with this specific shared partner via a biomarker relationship? | epilepsy | Medium | convergence | {"qa_id":"medium_convergence_06145","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CPLX1 and PPFIA1 share common binding partners. One of these shared partners is described as binding in an antiparallel alpha-helical conformation to the gro... | |
medium_convergence_06146 | LAT and GRB2 both interact with a shared protein. Evidence indicates that this shared protein is a hematopoietic cell-specific protein first identified as a Grb2-binding protein in T cells. Which protein is encoded by the gene corresponding to this shared entity? | Lymphocyte cytosolic protein 2 | Medium | convergence | {"qa_id":"medium_convergence_06146","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAT and GRB2 both interact with a shared protein. Evidence indicates that this shared protein is a hematopoietic cell-specific protein first identified as a ... | |
medium_convergence_06147 | Both Human alphaherpesvirus 3 and Measles morbillivirus are known to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.168 and an adjusted p-value of 2.019e-05. In which cell type is this gene reported to be enriched? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_06147","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Measles morbillivirus are known to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (s... | |
medium_convergence_06148 | HIST1H4A and CBFB share a common interaction partner. Evidence regarding this shared partner states: 'The solution NMR structure of [Gene A]-PHD6 in complex with a H4K16ac peptide along with binding and mutational analyses reveal unique mechanistic features underlying recognition of H4K16ac.' Which gene interacts with ... | SETD1A | Medium | convergence | {"qa_id":"medium_convergence_06148","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIST1H4A and CBFB share a common interaction partner. Evidence regarding this shared partner states: 'The solution NMR structure of [Gene A]-PHD6 in complex ... | |
medium_convergence_06149 | HDAC6 and SEPTIN9 share common interaction partners. One such partner is a component of the core septin hetero-octamer in human cells, which consists of SEPT2, SEPT6, this specific entity, and SEPT9. Which cell type is enriched for this specific entity? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_06149","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and SEPTIN9 share common interaction partners. One such partner is a component of the core septin hetero-octamer in human cells, which consists of SEPT... | |
medium_convergence_06150 | IFNA2 and IFNA17 both interact with a specific receptor. Evidence regarding one of these shared receptors states: 'The 25 kDa, non-glycosylated [receptor]-EC is a stable, fully active protein, which inhibits antiviral activity of IFNalpha2.' Which protein is encoded by this receptor? | Interferon alpha/beta receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_06150","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IFNA2 and IFNA17 both interact with a specific receptor. Evidence regarding one of these shared receptors states: 'The 25 kDa, non-glycosylated [receptor]-EC... | |
medium_convergence_06151 | RAF1 and BCAR1 both interact with a specific Ras-related protein. Evidence regarding this shared partner states: 'The X-ray crystal structure of the complex between the Ras-related protein in the GTP-analogue (GppNHp) form and the Ras-binding domain (RBD) of the Ras effector molecule c-Raf1, a Ser/Thr-specific protein ... | Ras-related protein Rap-1A | Medium | convergence | {"qa_id":"medium_convergence_06151","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAF1 and BCAR1 both interact with a specific Ras-related protein. Evidence regarding this shared partner states: 'The X-ray crystal structure of the complex ... | |
medium_convergence_06152 | UBC and VCP each interact with more than one shared protein. Evidence concerning one such shared entity reports: 'The PUB domain mediated robust binding to the carboxy-terminus of p97, while the UBX domain did not contribute to p97 binding.' Which protein is encoded by that entity? | UBX domain-containing protein 6 | Medium | convergence | {"qa_id":"medium_convergence_06152","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBC and VCP each interact with more than one shared protein. Evidence concerning one such shared entity reports: 'The PUB domain mediated robust binding to t... | |
medium_convergence_06153 | Hepacivirus C and Rhinovirus A both downregulate a specific gene. Experimental data for this gene shows a log2 fold change of -1.649 and an adjusted p-value of 0.000522. Which cellular component is this gene located in? | extracellular exosome | Medium | convergence | {"qa_id":"medium_convergence_06153","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Rhinovirus A both downregulate a specific gene. Experimental data for this gene shows a log2 fold change of -1.649 and an adjusted p-value ... | |
medium_convergence_06154 | YAP1 and PRKN (PARK2) share common interacting partners. One such shared partner is characterized by evidence stating that Trp119 and Tyr140 on this protein directly interact with the N-terminal region of YAP1, facilitating the formation of a complex between this protein and YAP1 for YAP1 deubiquitylation. Which protei... | Eukaryotic translation initiation factor 3 subunit H | Medium | convergence | {"qa_id":"medium_convergence_06154","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and PRKN (PARK2) share common interacting partners. One such shared partner is characterized by evidence stating that Trp119 and Tyr140 on this protein ... | |
medium_convergence_06155 | HDAC5 and PARP1 both interact with a shared transcriptional repressor. Evidence indicates that class II HDACs (HDAC4 and 5), which are Ca/calmodulin-dependent kinase (CaMK)-responsive repressors of hypertrophic signaling, associate with this repressor and participate in its-mediated repression. Which cell type is enric... | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_06155","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC5 and PARP1 both interact with a shared transcriptional repressor. Evidence indicates that class II HDACs (HDAC4 and 5), which are Ca/calmodulin-dependen... | |
medium_convergence_06156 | SMG1 and TTI2 both interact with a common protein. Evidence regarding this shared partner states: 'Each of the PIKK family members associated with this protein in vivo and in vitro experiments indicated that this protein binds to part of the HEAT repeat segments of ATM and mTOR.' Which disease is associated with this s... | TELO2-related intellectual disability-neurodevelopmental disorder | Medium | convergence | {"qa_id":"medium_convergence_06156","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMG1 and TTI2 both interact with a common protein. Evidence regarding this shared partner states: 'Each of the PIKK family members associated with this prote... | |
medium_convergence_06159 | CEBPA and HSF1 share multiple interacting partners. One such shared partner is described in the following context: 'Subsequently, this protein translocated into the nucleus and bound cooperatively with nuclear HSF1 (heat shock transcription factor 1) onto the ATG7 promoter, upregulated ATG7 expression in the advanced s... | 26S proteasome non-ATPase regulatory subunit 10 | Medium | convergence | {"qa_id":"medium_convergence_06159","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPA and HSF1 share multiple interacting partners. One such shared partner is described in the following context: 'Subsequently, this protein translocated i... | |
medium_convergence_06160 | CDK9 and EP300 both interact with a specific shared protein. Evidence indicates that this protein can interact directly with p300 and be acetylated by it. Which protein is encoded by the gene corresponding to this shared entity? | Heterogeneous nuclear ribonucleoproteins A2/B1 | Medium | convergence | {"qa_id":"medium_convergence_06160","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK9 and EP300 both interact with a specific shared protein. Evidence indicates that this protein can interact directly with p300 and be acetylated by it. Wh... | |
medium_convergence_06161 | CSNK2A2 and EZH2 share multiple interacting partners. One such shared partner has been experimentally shown to interact with the H3K27 methyltransferase EZH2 within a reconstituted complex. Which disease is associated with this specific shared partner via a biomarker relationship? | mycosis fungoides | Medium | convergence | {"qa_id":"medium_convergence_06161","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A2 and EZH2 share multiple interacting partners. One such shared partner has been experimentally shown to interact with the H3K27 methyltransferase EZH2... | |
medium_convergence_06162 | EGFR and ALK each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Unexpectedly, the well known endoplasmic reticulum associated translocon Sec61β is found to reside in the INM and associate with EGFR.' Which protein is encoded by that entity? | Protein transport protein Sec61 subunit alpha isoform 1 | Medium | convergence | {"qa_id":"medium_convergence_06162","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and ALK each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Unexpectedly, the well known endoplasmic r... | |
medium_convergence_06163 | Primate erythroparvovirus 1 and Zaire ebolavirus both upregulate a specific gene in erythroid progenitor cells. Experimental data from study GSE103460 indicates that for one such shared target, the log2 fold change is 1.023 and the adjusted p-value is 0.04293. Which protein is encoded by this gene? | Interferon-stimulated gene 20 kDa protein | Medium | convergence | {"qa_id":"medium_convergence_06163","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Primate erythroparvovirus 1 and Zaire ebolavirus both upregulate a specific gene in erythroid progenitor cells. Experimental data from study GSE103460 indica... | |
medium_convergence_06165 | C1D and DIS3 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Here, we demonstrate the association of two different Dis3p homologs--hDIS3 and hDIS3L--with the human exosome core.' Which protein is connected to that entity through the 'encodes' relationship? | Exosome complex component RRP43 | Medium | convergence | {"qa_id":"medium_convergence_06165","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"C1D and DIS3 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'Here, we demonstrate the association of... | |
medium_convergence_06166 | ARNT and RB1 share common interacting partners. One such shared partner is characterized by the following observation: when added to nonapoptotic cell extract, it causes efficient internal cleavage of cellular RB. Which disease is associated with this shared partner through genomic alterations? | ovarian cancer | Medium | convergence | {"qa_id":"medium_convergence_06166","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARNT and RB1 share common interacting partners. One such shared partner is characterized by the following observation: when added to nonapoptotic cell extrac... | |
medium_convergence_06167 | HNRNPA1 and MYC both interact with a shared protein. Evidence for one such shared partner states: 'In in vitro pull-down assays, HAP interacts with hnRNP A1, through its S/K-R/E-rich region, and with several other hnRNPs.' Which protein is encoded by the gene corresponding to this shared partner? | Scaffold attachment factor B1 | Medium | convergence | {"qa_id":"medium_convergence_06167","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HNRNPA1 and MYC both interact with a shared protein. Evidence for one such shared partner states: 'In in vitro pull-down assays, HAP interacts with hnRNP A1,... | |
medium_convergence_06168 | BIRC2 and FADD both interact with a specific shared protein. Experimental evidence indicates that while c-IAP1 binds to both TRAF2 and this shared protein in vitro, it only ubiquitinates TRAF2. Which protein is encoded by the gene corresponding to this shared entity? | TNF receptor-associated factor 1 | Medium | convergence | {"qa_id":"medium_convergence_06168","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and FADD both interact with a specific shared protein. Experimental evidence indicates that while c-IAP1 binds to both TRAF2 and this shared protein in... | |
medium_convergence_06169 | NUDT21 and SIN3A both interact with a specific transcriptional repressor. Evidence indicates that this repressor, along with PLZF, interacts with corepressor proteins including mSin3A. Which protein is encoded by this shared interacting partner? | B-cell lymphoma 6 protein | Medium | convergence | {"qa_id":"medium_convergence_06169","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUDT21 and SIN3A both interact with a specific transcriptional repressor. Evidence indicates that this repressor, along with PLZF, interacts with corepressor... | |
medium_convergence_06170 | RHOA and ZRANB1 both interact with a shared protein. Evidence indicates that the binding site for RHOA on this shared protein is located within its immunoglobulin-like domain. Which gene product does this shared protein bind to? | WASL | Medium | convergence | {"qa_id":"medium_convergence_06170","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOA and ZRANB1 both interact with a shared protein. Evidence indicates that the binding site for RHOA on this shared protein is located within its immunoglo... | |
medium_convergence_06171 | AGT and REN are both involved in multiple shared biological processes. One such process is linked to evidence stating that rats harboring the human renin and angiotensinogen genes (dTGR) exhibit angiotensin (ANG) II/hypertension-induced cardiac damage. Which biological process, connected to this entity via an 'is a' re... | regulation of biological quality | Medium | convergence | {"qa_id":"medium_convergence_06171","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AGT and REN are both involved in multiple shared biological processes. One such process is linked to evidence stating that rats harboring the human renin and... | |
medium_convergence_06172 | NEDD4L and RAF1 both interact with a shared protein. Evidence indicates that this protein interacts in vitro and in vivo with endogenous Raf-1 and coimmunoprecipitates with Raf-1 in murine thymocytes treated with DEX. In which cell type is this shared protein enriched? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06172","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4L and RAF1 both interact with a shared protein. Evidence indicates that this protein interacts in vitro and in vivo with endogenous Raf-1 and coimmunopr... | |
medium_convergence_06173 | TRIM28 and FANCD2 share common interaction partners. One such shared partner is supported by evidence stating: 'We found that FANCD2 can interact directly with minichromosome maintenance (MCM) proteins.' Which protein is encoded by this shared interaction partner? | DNA replication licensing factor MCM7 | Medium | convergence | {"qa_id":"medium_convergence_06173","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and FANCD2 share common interaction partners. One such shared partner is supported by evidence stating: 'We found that FANCD2 can interact directly wi... | |
medium_convergence_06174 | Both Human alphaherpesvirus 3 and Rhinovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately 3.05 and an adjusted p-value of 4.46e-12. Which disease is associated with this gene through genomic altera... | oropharyngeal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06174","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Rhinovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (study... | |
medium_convergence_06175 | Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 3.22 and an adjusted p-value of approximately 0.0256. Which protein is encoded by this gene? | Amine oxidase [copper-containing] 2 | Medium | convergence | {"qa_id":"medium_convergence_06175","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2... | |
medium_convergence_06176 | Fibrinogen (FGB) and IKBKG both interact with a shared protein. Evidence indicates that upon IL-1 stimulation, this protein acquires Lys63-linked polyubiquitin chains and specifically binds to NEMO, the regulatory subunit of the IkappaB kinase (IKK) complex. Which cell type is this protein enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_06176","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Fibrinogen (FGB) and IKBKG both interact with a shared protein. Evidence indicates that upon IL-1 stimulation, this protein acquires Lys63-linked polyubiquit... | |
medium_convergence_06177 | CSNK2A1 and ABL1 both interact with a specific gene product. Experimental evidence indicates that the interaction between Nuclear CK2 and TAp73, confirmed by co-immunoprecipitation, is attenuated by a CK2 inhibitor or by a T27A point mutation at a predicted CK2 threonine phospho-acceptor site on TAp73. Which protein is... | Tumor protein p73 | Medium | convergence | {"qa_id":"medium_convergence_06177","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and ABL1 both interact with a specific gene product. Experimental evidence indicates that the interaction between Nuclear CK2 and TAp73, confirmed by... | |
medium_convergence_06178 | Urokinase and Anagrelide both interact with a specific drug. Clinical evidence regarding this drug describes a study where 96 patients with acute cerebral infarction (ACI) without clear culprit vessels were randomized into a control group receiving urokinase and an observation group receiving urokinase combined with th... | acute coronary syndrome | Medium | convergence | {"qa_id":"medium_convergence_06178","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Urokinase and Anagrelide both interact with a specific drug. Clinical evidence regarding this drug describes a study where 96 patients with acute cerebral in... | |
medium_convergence_06179 | FBXW11 and NPM1 share multiple interacting partners. One such shared partner is identified in a study using an unbiased screen, which reports that this entity interacts with the F-box protein beta-TrCP. Which protein is encoded by this shared interacting partner? | RE1-silencing transcription factor | Medium | convergence | {"qa_id":"medium_convergence_06179","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW11 and NPM1 share multiple interacting partners. One such shared partner is identified in a study using an unbiased screen, which reports that this entit... | |
medium_convergence_06180 | Vaccinia virus and Influenza A virus both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of approximately -1.167 and an adjusted p-value of 0.005373. Which protein interacts with this downregulated gene? | AIFM1 | Medium | convergence | {"qa_id":"medium_convergence_06180","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Influenza A virus both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates... | |
medium_convergence_06181 | Both 'response to catecholamine' and 'response to serotonin' are subtypes of a shared biological process. Evidence regarding this shared process states: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a re... | response to nitrogen compound | Medium | convergence | {"qa_id":"medium_convergence_06181","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both 'response to catecholamine' and 'response to serotonin' are subtypes of a shared biological process. Evidence regarding this shared process states: 'Any... | |
medium_convergence_06182 | MYC and RPA2 share common interaction partners. One such partner is involved in a complex where RPA physically interacts with it to form RPA-[partner]-H3.3 complexes, and this partner co-localizes with RPA and H3.3 at gene promoters and enhancers. Which protein is encoded by this shared interaction partner? | Protein HIRA | Medium | convergence | {"qa_id":"medium_convergence_06182","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and RPA2 share common interaction partners. One such partner is involved in a complex where RPA physically interacts with it to form RPA-[partner]-H3.3 c... | |
medium_convergence_06183 | CHRNA3 and SLC10A4 each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that P2X2 co-immunoprecipitated the α3β2 nicotinic acetylcholine receptor (nAChR), but not the α4β2 nAChR, in both HEK cells and rat hippocampal membranes, indicating a physical associati... | nicotine dependence | Medium | convergence | {"qa_id":"medium_convergence_06183","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHRNA3 and SLC10A4 each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that P2X2 co-immunopreci... | |
medium_convergence_06184 | KCNA3 and STK4 both interact with a common protein. Evidence indicates that Kv1.3 forms a complex with this shared entity in the nucleus. Which protein is encoded by this shared entity? | Nucleolar transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_06184","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNA3 and STK4 both interact with a common protein. Evidence indicates that Kv1.3 forms a complex with this shared entity in the nucleus. Which protein is en... | |
medium_convergence_06185 | SH3KBP1 and YWHAH both interact with a specific shared protein. Evidence regarding this shared protein states: 'We found that the SH3 domains of CIN85 bound to a PXXXPR motif located near the C-terminus of hTTP.' Which protein is encoded by this shared entity? | mRNA decay activator protein ZFP36 | Medium | convergence | {"qa_id":"medium_convergence_06185","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SH3KBP1 and YWHAH both interact with a specific shared protein. Evidence regarding this shared protein states: 'We found that the SH3 domains of CIN85 bound ... | |
medium_convergence_06186 | PRKN and USP7 share multiple interacting partners. One such shared partner has been shown to interact with USP7 to prevent the ubiquitination-mediated degradation of β-Catenin. Which protein is encoded by this specific shared partner? | WD repeat-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06186","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and USP7 share multiple interacting partners. One such shared partner has been shown to interact with USP7 to prevent the ubiquitination-mediated degrad... | |
medium_convergence_06187 | WNT2 and WNT2B are both involved in more than one shared biological process. Evidence indicates that in the optic cup, Wnt2, Wnt2b, and Wnt9a were localized in the rim of the optic cup (presumptive iris). Which biological process, connected to the entity described by this localization evidence through a 'part of' relat... | camera-type eye morphogenesis | Medium | convergence | {"qa_id":"medium_convergence_06187","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WNT2 and WNT2B are both involved in more than one shared biological process. Evidence indicates that in the optic cup, Wnt2, Wnt2b, and Wnt9a were localized ... | |
medium_convergence_06188 | Both Human respirovirus 3 and Influenza A virus are associated with the upregulation of a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) reports a log2 fold change of approximately 1.478 and an adjusted p-value of 0.04933. Which protein is encoded by t... | Urokinase plasminogen activator surface receptor | Medium | convergence | {"qa_id":"medium_convergence_06188","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Influenza A virus are associated with the upregulation of a specific gene. Experimental data for this gene in a non-small cell ... | |
medium_convergence_06189 | MAPK8IP2 and MAPK9 both interact with a shared protein. Evidence regarding this shared entity states: 'The scaffold proteins encoded by MAPK8IP1 and MAPK8IP2 interact to form oligomeric complexes that accumulate in peripheral cytoplasmic projections extended at the cell surface.' Which protein is encoded by this shared... | C-Jun-amino-terminal kinase-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06189","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK8IP2 and MAPK9 both interact with a shared protein. Evidence regarding this shared entity states: 'The scaffold proteins encoded by MAPK8IP1 and MAPK8IP2... | |
medium_convergence_06190 | GTF2A2 and TAF12 both interact with a shared protein partner. Evidence regarding one such partner states: 'The crystal structure is presented of a complex formed by the interacting domains from two subunits of the general transcription factor TFIID, the human TATA binding protein-associated factors hTAF4 (hTAF(II)135) ... | Transcription initiation factor TFIID subunit 4 | Medium | convergence | {"qa_id":"medium_convergence_06190","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2A2 and TAF12 both interact with a shared protein partner. Evidence regarding one such partner states: 'The crystal structure is presented of a complex fo... | |
medium_convergence_06191 | FOXE3 and WNT2 are both implicated in multiple shared biological processes. One such shared process is associated with an entity where evidence indicates that most tissues of the anterior segment—specifically the iris, cornea, ciliary body, and trabecular meshwork—are malformed or exhibit differentiation defects. Which... | camera-type eye morphogenesis | Medium | convergence | {"qa_id":"medium_convergence_06191","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FOXE3 and WNT2 are both implicated in multiple shared biological processes. One such shared process is associated with an entity where evidence indicates tha... | |
medium_convergence_06192 | LSM12 and DDX6 share interaction partners. One such shared partner is the subject of a study reporting: 'We also determined the crystal structure of LSM14 bound to the C-terminal RecA-like domain of DDX6.' Which protein is encoded by this shared entity? | Protein LSM14 homolog A | Medium | convergence | {"qa_id":"medium_convergence_06192","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LSM12 and DDX6 share interaction partners. One such shared partner is the subject of a study reporting: 'We also determined the crystal structure of LSM14 bo... | |
medium_convergence_06193 | Both Human mastadenovirus C and Zika virus are known to upregulate a specific shared gene. Experimental data for this gene, derived from a study on lung fibroblast cell lines (GSE120891), reports a log2 fold change of approximately 2.01 and an adjusted p-value of approximately 0.038. Which cell type is this gene enrich... | basophil | Medium | convergence | {"qa_id":"medium_convergence_06193","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Zika virus are known to upregulate a specific shared gene. Experimental data for this gene, derived from a study on lung fibr... | |
medium_convergence_06194 | Vaccinia virus and Human mastadenovirus C both upregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 1.48 and an adjusted p-value of 2.171e-10. Which disease is associated with this gene through genomic alterations? | hypertensive disorder | Medium | convergence | {"qa_id":"medium_convergence_06194","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human mastadenovirus C both upregulate a specific gene. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) rep... | |
medium_convergence_06195 | GATA1 and HIST1H4A share common binding partners. One such partner is implicated in a study describing the solution NMR structure of MLL4-PHD6 in complex with a H4K16ac peptide, which reveals mechanistic features underlying the recognition of H4K16ac. Which protein encodes the enzyme corresponding to this shared bindin... | Histone-lysine N-methyltransferase 2C | Medium | convergence | {"qa_id":"medium_convergence_06195","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GATA1 and HIST1H4A share common binding partners. One such partner is implicated in a study describing the solution NMR structure of MLL4-PHD6 in complex wit... | |
medium_convergence_06196 | Vaccinia virus and Dengue virus both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of approximately 5.997 and an adjusted p-value of approximately 5.936e-09. Which disease is associated with genomic alterations in this gene? | Roberts-SC phocomelia syndrome | Medium | convergence | {"qa_id":"medium_convergence_06196","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Dengue virus both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) show... | |
medium_convergence_06197 | STUB1 and GRB2 share multiple interacting partners. One such shared partner exhibits specific behavior upon 17-AAG treatment: it associates with the co-chaperone HSP70 and the ubiquitin E3 ligase CHIP. Which protein is encoded by this specific shared partner? | Tyrosine-protein kinase receptor UFO | Medium | convergence | {"qa_id":"medium_convergence_06197","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and GRB2 share multiple interacting partners. One such shared partner exhibits specific behavior upon 17-AAG treatment: it associates with the co-chape... | |
medium_convergence_06198 | Human alphaherpesvirus 1 and Dengue virus both upregulate a specific gene. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.123 and an adjusted p-value of approximately 0.04157. Which disease is associated with genomic alterations in this gene? | Histiocytic medullary reticulosis | Medium | convergence | {"qa_id":"medium_convergence_06198","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Dengue virus both upregulate a specific gene. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports... | |
medium_convergence_06199 | BRD4 and H2AX share multiple interacting partners. One such shared partner forms a complex with BMI1 that interacts with H2AX in a DNA damage-dependent manner and is required for the monoubiquitination of H2AX at Lys(119)/Lys(120). Which protein is encoded by this shared partner? | E3 ubiquitin-protein ligase RING2 | Medium | convergence | {"qa_id":"medium_convergence_06199","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and H2AX share multiple interacting partners. One such shared partner forms a complex with BMI1 that interacts with H2AX in a DNA damage-dependent manne... | |
medium_convergence_06200 | Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.98 and an adjusted p-value of approximately 0.028. Which protein does this gene product interact with? | S100A1 | Medium | convergence | {"qa_id":"medium_convergence_06200","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2... | |
medium_convergence_06201 | CDK2 and EP300 share multiple interacting partners. One such shared partner is reported to form a complex with Cdk1-cyclin A both in vitro and in vivo. Which disease is associated with this specific shared partner through genomic alterations? | lung cancer | Medium | convergence | {"qa_id":"medium_convergence_06201","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and EP300 share multiple interacting partners. One such shared partner is reported to form a complex with Cdk1-cyclin A both in vitro and in vivo. Which... | |
medium_convergence_06202 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene reports a log2 fold change of 1.588 and an adjusted p-value of 0.04214. Which cell type is this gene enriched in? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_06202","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene reports a log2 fold change of 1.588 and... | |
medium_convergence_06203 | Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE111036) show a log2 fold change of approximately 9.63 and an adjusted p-value of 0.0471. Which protein is encoded by this gene? | Interferon beta | Medium | convergence | {"qa_id":"medium_convergence_06203","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE111036)... | |
medium_convergence_06204 | FLII and ANLN share common interaction partners. One such partner is identified in a study reporting the discovery of two related genes, LRRFIP1 and the entity in question, which encode proteins that interact with the LRR domain of human FLI via the yeast two-hybrid system. What molecular function is enabled by this en... | LRR domain binding | Medium | convergence | {"qa_id":"medium_convergence_06204","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FLII and ANLN share common interaction partners. One such partner is identified in a study reporting the discovery of two related genes, LRRFIP1 and the enti... |
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