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medium_convergence_05979 | HSP90AA1 and IKBKB both interact with a shared protein. Evidence indicates that functional inhibition of Hsp90 by the anti-tumor agent geldanamycin (GA) disrupts its interaction with this shared protein, leading to its degradation and blocking p100 processing. Which protein is encoded by the gene corresponding to this ... | Mitogen-activated protein kinase kinase kinase 14 | Medium | convergence | {"qa_id":"medium_convergence_05979","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and IKBKB both interact with a shared protein. Evidence indicates that functional inhibition of Hsp90 by the anti-tumor agent geldanamycin (GA) disr... | |
medium_convergence_05980 | ATM and TP53 share multiple interacting partners. One such shared partner is part of a complex that associates with p53 on chromatin, as demonstrated by unbiased protein affinity purification. Which gene interacts with this specific shared partner? | USP15 | Medium | convergence | {"qa_id":"medium_convergence_05980","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and TP53 share multiple interacting partners. One such shared partner is part of a complex that associates with p53 on chromatin, as demonstrated by unbi... | |
medium_convergence_05981 | PRKN (PARK2) and NOSIP share common interaction partners. One such shared partner is implicated in a study stating: 'Furthermore, we found that the protein product of the gene corresponding to this shared partner and PARK2 form a complex, suggesting that they might regulate mitophagy through protein-protein interaction... | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | Medium | convergence | {"qa_id":"medium_convergence_05981","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN (PARK2) and NOSIP share common interaction partners. One such shared partner is implicated in a study stating: 'Furthermore, we found that the protein p... | |
medium_convergence_05982 | SH3KBP1 and BTC each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'Here, we show that Sprouty2 associates with CIN85 and acts at the interface between Cbl and CIN85 to inhibit EGFR downregulation.' Which disease is connected to that specific entity through genomic... | Metaphyseal chondrodysplasia, McKusick type | Medium | convergence | {"qa_id":"medium_convergence_05982","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SH3KBP1 and BTC each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'Here, we show that Sprouty2 associ... | |
medium_convergence_05983 | CDH2 and CDH15 each interact with multiple shared partners. One such shared partner is described in evidence stating: 'In one, the transmembrane glycoproteins N-cadherin and cadherin-11 [which also occur in heterotypic ('mixed') complexes] are associated with alpha- and beta-catenin, plakoglobin (proportions variable a... | Catenin alpha-1 | Medium | convergence | {"qa_id":"medium_convergence_05983","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDH2 and CDH15 each interact with multiple shared partners. One such shared partner is described in evidence stating: 'In one, the transmembrane glycoprotein... | |
medium_convergence_05984 | MAPK14 and MAPK11 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'We found that this entity, but not MEF2B or MEF2D, is a substrate for p38.' Which protein is connected to that entity through the 'encodes' relationship? | Myocyte-specific enhancer factor 2A | Medium | convergence | {"qa_id":"medium_convergence_05984","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK14 and MAPK11 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'We found that this entity, but not... | |
medium_convergence_05985 | EP300 and KMT2C share multiple binding partners. One such partner is implicated in a specific molecular mechanism described as follows: 'This enhancement was due to direct protein-protein interactions of both pax-6 and cdx-2 with the N-terminal C/H1 domain of p300.' Identify the disease associated with this specific pa... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_05985","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and KMT2C share multiple binding partners. One such partner is implicated in a specific molecular mechanism described as follows: 'This enhancement was... | |
medium_convergence_05986 | KAT5 and YWHAQ both interact with a specific shared protein. Evidence indicates that Tip60 associates with this protein through its N-terminal zinc finger-containing region, and that the activity of this protein is required for the repressive effect of Tip60. Which gene encodes this protein? | Histone deacetylase 7 | Medium | convergence | {"qa_id":"medium_convergence_05986","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and YWHAQ both interact with a specific shared protein. Evidence indicates that Tip60 associates with this protein through its N-terminal zinc finger-co... | |
medium_convergence_05987 | CTNNB1 and SIRT1 share common interacting partners. One such shared partner has been shown to interact with beta-catenin via Co-immunoprecipitation (Co-IP). Which protein is encoded by this shared partner? | Zinc finger MIZ domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_05987","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and SIRT1 share common interacting partners. One such shared partner has been shown to interact with beta-catenin via Co-immunoprecipitation (Co-IP). ... | |
medium_convergence_05988 | NMU and GNA15 both interact with a specific receptor protein. Evidence indicates that radiolabeled neuromedin U binds with high affinity to membrane fractions prepared from cells expressing this receptor. Which protein is encoded by the gene corresponding to this receptor? | Neuromedin-U receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_05988","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NMU and GNA15 both interact with a specific receptor protein. Evidence indicates that radiolabeled neuromedin U binds with high affinity to membrane fraction... | |
medium_convergence_05989 | Both Influenza A virus and Orthohepevirus A are associated with the upregulation of a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) reports a log2 fold change of approximately 1.98 and an adjusted p-value of 1.145e-09. What is the name of the protein ... | Zinc finger protein 518A | Medium | convergence | {"qa_id":"medium_convergence_05989","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Orthohepevirus A are associated with the upregulation of a specific gene. Experimental data for this gene in a non-small cell lung... | |
medium_convergence_05990 | ARCN1 and CAPZB both interact with a shared protein partner. Evidence regarding this partner includes findings from immunoprecipitation and two-hybrid system analysis within a complete COP screen, which demonstrated physical interactions between alpha- and epsilon-COPs, as well as between beta- and delta-COPs. Which pr... | Coatomer subunit beta | Medium | convergence | {"qa_id":"medium_convergence_05990","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARCN1 and CAPZB both interact with a shared protein partner. Evidence regarding this partner includes findings from immunoprecipitation and two-hybrid system... | |
medium_convergence_05991 | Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately 2.507 and an adjusted p-value of approximately 0.000322. Which cellular component is this gene located in? | receptor complex | Medium | convergence | {"qa_id":"medium_convergence_05991","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both upregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold... | |
medium_convergence_05992 | PARP1 and MYC both interact with a shared protein. Evidence indicates that for this specific protein, the N-terminal region interacts with c-Myc, while the rest of the helicase interacts with the c-Myc E3 ligase Fbw7. Which cell type is this protein enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_05992","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and MYC both interact with a shared protein. Evidence indicates that for this specific protein, the N-terminal region interacts with c-Myc, while the r... | |
medium_convergence_05993 | BCL6 and TP53 share common interacting partners. One such shared partner is an orphan F-box protein that is part of a SKP1–CUL1–F-box protein (SCF) ubiquitin ligase complex, which targets the partner for ubiquitylation and proteasomal degradation. Which disease is associated with this specific shared partner as a bioma... | osteosarcoma | Medium | convergence | {"qa_id":"medium_convergence_05993","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BCL6 and TP53 share common interacting partners. One such shared partner is an orphan F-box protein that is part of a SKP1–CUL1–F-box protein (SCF) ubiquitin... | |
medium_convergence_05995 | PARP1 and EZH2 share a common interacting partner. Evidence indicates that this partner is an E3 ubiquitin ligase that engages in a physical and functional poly(ADP-ribose)-mediated interaction with PARP1, influencing specific cellular processes. Which disease is associated with this entity through genomic alterations? | gastric cancer | Medium | convergence | {"qa_id":"medium_convergence_05995","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and EZH2 share a common interacting partner. Evidence indicates that this partner is an E3 ubiquitin ligase that engages in a physical and functional p... | |
medium_convergence_05996 | AKT1 and MAPK8 share a common interacting partner. Evidence indicates that this shared partner binds to c-Jun N-terminal kinase (JNK) in vitro and in vivo, but does not interact with p38- or ERK1/2-family MAPKs. Which protein is connected to this shared entity through the 'encodes' relationship? | Target of rapamycin complex 2 subunit MAPKAP1 | Medium | convergence | {"qa_id":"medium_convergence_05996","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and MAPK8 share a common interacting partner. Evidence indicates that this shared partner binds to c-Jun N-terminal kinase (JNK) in vitro and in vivo, b... | |
medium_convergence_05997 | KAT5 and HDAC1 both interact with a shared transcription factor. Evidence regarding this shared entity states: 'The novel Bcl-3 interactors Jab1, Pirin, Tip60 and Bard1 are nuclear proteins which also bind to other transcription factors including c-Jun, nuclear factor I (NFI), HIV-1 Tat or the tumor suppressor and PolI... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_05997","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and HDAC1 both interact with a shared transcription factor. Evidence regarding this shared entity states: 'The novel Bcl-3 interactors Jab1, Pirin, Tip6... | |
medium_convergence_05998 | CCDC22 and CUL1 both interact with a shared protein that functions as a subunit of the SCF (SKP1/cullin-1/F-box protein) E3 ubiquitin ligase complex. Which cell type is this shared protein enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_05998","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCDC22 and CUL1 both interact with a shared protein that functions as a subunit of the SCF (SKP1/cullin-1/F-box protein) E3 ubiquitin ligase complex. Which c... | |
medium_convergence_05999 | Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE100839) reports a log2 fold change of approximately -1.249 and an adjusted p-value of 0.03269. Which protein is encoded by this gene? | Pleckstrin homology-like domain family A member 1 | Medium | convergence | {"qa_id":"medium_convergence_05999","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE100839... | |
medium_convergence_06000 | BABAM1 and PTEN both interact with a specific protein. Evidence indicates that tankyrases interact with and ribosylate this protein, promoting its recognition by the PAR-binding E3 ubiquitin ligase RNF146, which leads to the protein's ubiquitination and degradation. Which protein is encoded by the gene corresponding to... | Poly [ADP-ribose] polymerase tankyrase-2 | Medium | convergence | {"qa_id":"medium_convergence_06000","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BABAM1 and PTEN both interact with a specific protein. Evidence indicates that tankyrases interact with and ribosylate this protein, promoting its recognitio... | |
medium_convergence_06001 | CLTA and AP2B1 each interact with more than one shared protein. Evidence concerning one shared entity reports that Yeast two-hybrid analyses and GST pulldown assays reveal that the LL signal constitutes a binding site for the beta2-adaptin subunit of the heterotetrameric AP-2 adaptor complex, implicating this motif in ... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_06001","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLTA and AP2B1 each interact with more than one shared protein. Evidence concerning one shared entity reports that Yeast two-hybrid analyses and GST pulldown... | |
medium_convergence_06002 | Dengue virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately -1.597 and an adjusted p-value of 0.04499. Which cell type is this gene enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_06002","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fo... | |
medium_convergence_06003 | E2F1 and FHL1 each interact with more than one shared gene product. Evidence concerning one shared entity reports that Glutathione S-transferase pull-down assays, coimmunoprecipitation experiments, and chromatin immunoprecipitation analysis were used to evidence interaction between a nuclear receptor-interacting protei... | Nuclear receptor-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06003","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"E2F1 and FHL1 each interact with more than one shared gene product. Evidence concerning one shared entity reports that Glutathione S-transferase pull-down as... | |
medium_convergence_06004 | PRKN and LATS1 share multiple interacting partners. One such shared partner is identified in an interactome screen where a phosphatase was found to interact with several Hippo pathway core kinases, specifically including the entity that acts as the direct kinase regulating the transcription co-activators YAP and TAZ. W... | post-traumatic stress disorder | Medium | convergence | {"qa_id":"medium_convergence_06004","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and LATS1 share multiple interacting partners. One such shared partner is identified in an interactome screen where a phosphatase was found to interact ... | |
medium_convergence_06005 | CHEK1 and CDC6 both interact with a shared protein. Evidence indicates that this protein localizes to the nucleus but only associates with Chk1 following replication stress or other types of DNA damage. Which disease is associated with this protein? | telangiectasis | Medium | convergence | {"qa_id":"medium_convergence_06005","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and CDC6 both interact with a shared protein. Evidence indicates that this protein localizes to the nucleus but only associates with Chk1 following rep... | |
medium_convergence_06006 | BET1 and COG1 both interact with a shared protein partner. Evidence regarding one such partner states: 'Our results suggest that this protein serves as a core component of the complex by interacting directly with COG1, COG2, COG5, and COG7.' Which protein is encoded by the gene corresponding to this specific shared par... | Conserved oligomeric Golgi complex subunit 4 | Medium | convergence | {"qa_id":"medium_convergence_06006","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BET1 and COG1 both interact with a shared protein partner. Evidence regarding one such partner states: 'Our results suggest that this protein serves as a cor... | |
medium_convergence_06007 | NBN and BARD1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We identified new CDK phosphorylation sites on the protein encoded by the shared gene and found that phosphorylation of these newly identified CDK sites induces association of that protein with the N-terminus ... | DNA endonuclease RBBP8 | Medium | convergence | {"qa_id":"medium_convergence_06007","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NBN and BARD1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We identified new CDK phosphorylation sites on... | |
medium_convergence_06008 | Both Human immunodeficiency virus 1 and Dengue virus are reported to upregulate a specific gene. In a study of macrophages (GSE108897), this gene showed a log2 fold change of 1.081 and an adjusted p-value of 0.007784. Which protein is encoded by this gene? | Cordon-bleu protein-like 1 | Medium | convergence | {"qa_id":"medium_convergence_06008","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are reported to upregulate a specific gene. In a study of macrophages (GSE108897), this gene showed a lo... | |
medium_convergence_06009 | IL1R1 and BTK both interact with a shared signaling molecule. Experimental evidence indicates that when human embryonic kidney cells (HEK293) over-expressing IL-1RI or HeLa cells are exposed to IL-1, this shared molecule rapidly associates with the IL-1RI complex and undergoes phosphorylation. Which cell type is this s... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_06009","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL1R1 and BTK both interact with a shared signaling molecule. Experimental evidence indicates that when human embryonic kidney cells (HEK293) over-expressing... | |
medium_convergence_06010 | CSNK1D and APC both interact with a shared protein. Experimental evidence indicates that this shared protein was co-precipitated with either GSK3beta or beta-catenin in both cell lines using immunoprecipitation. Which protein is encoded by the gene corresponding to this shared entity? | Glycogen synthase kinase-3 beta | Medium | convergence | {"qa_id":"medium_convergence_06010","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK1D and APC both interact with a shared protein. Experimental evidence indicates that this shared protein was co-precipitated with either GSK3beta or beta... | |
medium_convergence_06011 | CTNNB1 and HDAC2 both interact with a shared protein. Evidence indicates that this shared protein facilitates the binding of TCF4 to β-catenin, forming a stable complex that trans-activates downstream target genes. Which protein is encoded by the gene corresponding to this shared entity? | Transcription factor SOX-10 | Medium | convergence | {"qa_id":"medium_convergence_06011","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and HDAC2 both interact with a shared protein. Evidence indicates that this shared protein facilitates the binding of TCF4 to β-catenin, forming a sta... | |
medium_convergence_06013 | CARM1 and ESR1 share multiple interacting partners. One such shared partner forms a ternary complex with CARM1 and p300/CBP in cultured mammalian cells, a finding that supports a physiological role for the observed synergy. Which protein is encoded by this shared interacting partner? | Glutamate receptor-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06013","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CARM1 and ESR1 share multiple interacting partners. One such shared partner forms a ternary complex with CARM1 and p300/CBP in cultured mammalian cells, a fi... | |
medium_convergence_06015 | COPA and ANK1 both interact with a shared protein. Evidence regarding this shared entity states: 'Here we report the ubiquitous expression of two novel isotypes of coatomer subunits gamma- and zeta-COP that are incorporated into coatomer, and show that three isotypes exist of the complex defined by the subunit combinat... | Coatomer subunit gamma-2 | Medium | convergence | {"qa_id":"medium_convergence_06015","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPA and ANK1 both interact with a shared protein. Evidence regarding this shared entity states: 'Here we report the ubiquitous expression of two novel isoty... | |
medium_convergence_06016 | PRKACA and AKAP1 share multiple binding partners. One shared partner is described in evidence stating: 'Analysis of ternary complexes by the yeast two-hybrid system revealed that RIalpha and RIbeta homodimers as well as an RIalpha:RIbeta heterodimer and several of the mutants were able to bind to the R-binding domain o... | cAMP-dependent protein kinase type I-alpha regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_06016","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKACA and AKAP1 share multiple binding partners. One shared partner is described in evidence stating: 'Analysis of ternary complexes by the yeast two-hybrid... | |
medium_convergence_06017 | NUB1 and PSMA6 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'A yeast two-hybrid screen identified NEDD8 ultimate buster-1L as a non-covalent binding partner of the protein encoded by UBD, and this interaction was confirmed by coimmunoprecipitation and glutathio... | Ubiquitin D | Medium | convergence | {"qa_id":"medium_convergence_06017","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUB1 and PSMA6 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'A yeast two-hybrid screen identified ... | |
medium_convergence_06018 | MYC and RPL11 share multiple interacting partners. One such partner is described in the following evidence: 'Here, we show that glutamate-rich WD40 repeat containing 1 physically and functionally interacts with RPL11.' Which protein is encoded by this specific shared partner? | Glutamate-rich WD repeat-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06018","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and RPL11 share multiple interacting partners. One such partner is described in the following evidence: 'Here, we show that glutamate-rich WD40 repeat co... | |
medium_convergence_06019 | MYC and PPP2R2A share multiple interacting partners. One such shared partner is supported by evidence stating: 'Selected new c-MYC-associated proteins (a specific protein, FBX29, KU70, MCM7, Mi2-beta/CHD4, RNA Pol II, RFC2, RFC3, SV40 Large T Antigen, TCP1alpha, U5-116kD, ZNF281) were confirmed independently.' Which pr... | Cell cycle and apoptosis regulator protein 2 | Medium | convergence | {"qa_id":"medium_convergence_06019","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and PPP2R2A share multiple interacting partners. One such shared partner is supported by evidence stating: 'Selected new c-MYC-associated proteins (a spe... | |
medium_convergence_06020 | EP300 and HIST1H4A share multiple binding partners. One such shared partner is described as a histone acetyltransferase enzyme originally identified as a CBP/p300-binding protein. Which disease is associated with this specific shared partner through genomic alterations? | glioblastoma | Medium | convergence | {"qa_id":"medium_convergence_06020","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and HIST1H4A share multiple binding partners. One such shared partner is described as a histone acetyltransferase enzyme originally identified as a CBP... | |
medium_convergence_06022 | BIRC3 and IKBKE both interact with a shared protein. Evidence regarding this shared entity states: 'We show that cIAP1 and cIAP2 directly ubiquitinate this shared protein and induce constitutive ubiquitination in cancer cells and demonstrate that constitutively ubiquitinated this shared protein associates with the pros... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06022","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC3 and IKBKE both interact with a shared protein. Evidence regarding this shared entity states: 'We show that cIAP1 and cIAP2 directly ubiquitinate this s... | |
medium_convergence_06023 | Both Influenza A virus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE106279) reports a log2 fold change of approximately 1.816 and an adjusted p-value of 0.01848. Which protein does this upregulated gene prod... | TP53 | Medium | convergence | {"qa_id":"medium_convergence_06023","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a non-small cell lung adenocarcin... | |
medium_convergence_06024 | Both the positive regulation of T-helper 1 type immune response and type II interferon production are enabled by more than one cell type. One shared cell type is described as a mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses. Which cell type does this specific entity develop from? | activated CD4-positive type I NK T cell | Medium | convergence | {"qa_id":"medium_convergence_06024","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the positive regulation of T-helper 1 type immune response and type II interferon production are enabled by more than one cell type. One shared cell typ... | |
medium_convergence_06026 | SOX2 and TRIM21 share multiple interacting partners. One such partner is described in evidence stating: 'We demonstrate that tripartite motif-containing protein 21 physically associates with a histone methyltransferase and functions as a major negative regulator upstream of this enzyme through a proteasome-dependent me... | Histone-lysine N-methyltransferase SETD7 | Medium | convergence | {"qa_id":"medium_convergence_06026","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SOX2 and TRIM21 share multiple interacting partners. One such partner is described in evidence stating: 'We demonstrate that tripartite motif-containing prot... | |
medium_convergence_06027 | Both Influenza A virus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene, derived from bronchial epithelial cells in study GSE147507, reports a log2 fold change of 1.882 and an adjusted p-value of 2.255e-06. Which disease is associated with this gene through genomic alter... | coronary artery disorder | Medium | convergence | {"qa_id":"medium_convergence_06027","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene, derived from bronchial epithelial c... | |
medium_convergence_06029 | Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for this shared target in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 2.295 and an adjusted p-value of 0.01829. Which protein is encoded by this gene? | Solute carrier family 25 member 33 | Medium | convergence | {"qa_id":"medium_convergence_06029","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for this shared target in renal epithelial cells (study GSE... | |
medium_convergence_06030 | EME1 and FANCB both interact with a specific protein. Evidence regarding this protein states: 'Here, we report a novel component of this complex, termed FAAP100, which is essential for the stability of the core complex and directly interacts with FANCB and this protein to form a stable subcomplex.' Which protein is enc... | E3 ubiquitin-protein ligase FANCL | Medium | convergence | {"qa_id":"medium_convergence_06030","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EME1 and FANCB both interact with a specific protein. Evidence regarding this protein states: 'Here, we report a novel component of this complex, termed FAAP... | |
medium_convergence_06031 | Both Human gammaherpesvirus 4 and Zika virus are known to downregulate the expression of a specific gene. Experimental data for this gene in gamma delta T-lymphocytes (from study GSE13906) shows a log2 fold change of approximately -1.23 and an adjusted p-value of approximately 0.035. In which cell type is this gene enr... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06031","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human gammaherpesvirus 4 and Zika virus are known to downregulate the expression of a specific gene. Experimental data for this gene in gamma delta T-ly... | |
medium_convergence_06032 | Both Measles morbillivirus and Rift Valley fever phlebovirus are associated with the upregulation of a specific gene. Experimental data from a study on pleural mesothelioma cells (GSE117668) indicates that this gene exhibits a log2 fold change of approximately 1.453 and an adjusted p-value of 0.002421. Which protein is... | Zinc finger protein 107 | Medium | convergence | {"qa_id":"medium_convergence_06032","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Rift Valley fever phlebovirus are associated with the upregulation of a specific gene. Experimental data from a study on pleur... | |
medium_convergence_06033 | GTF2E1 and CCNT2 both interact with a shared protein partner. Evidence regarding this partner indicates that analyses of its binding to other general transcription factors revealed defects in binding to the basic helix-loop-helix motif of TFIIEβ. Which disease is associated with this shared protein partner? | trichothiodystrophy 6, nonphotosensitive | Medium | convergence | {"qa_id":"medium_convergence_06033","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2E1 and CCNT2 both interact with a shared protein partner. Evidence regarding this partner indicates that analyses of its binding to other general transcr... | |
medium_convergence_06034 | CEBPB and HDAC1 share multiple interacting partners. One such shared partner is implicated in evidence stating that it, along with Sp1, forms complexes that associate with histone deacetylases (HDACs) 1 and 2. Which protein is encoded by this shared partner? | Transcription factor Sp3 | Medium | convergence | {"qa_id":"medium_convergence_06034","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPB and HDAC1 share multiple interacting partners. One such shared partner is implicated in evidence stating that it, along with Sp1, forms complexes that ... | |
medium_convergence_06035 | RAD51 and BRIP1 both interact with a common protein partner. Experimental evidence indicates that for this specific partner, phosphorylation by c-Abl enhances the formation of a complex between the partner and RAD51, a process that facilitates their cooperation in recombination and repair. Which protein is encoded by t... | DNA repair protein RAD52 homolog | Medium | convergence | {"qa_id":"medium_convergence_06035","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD51 and BRIP1 both interact with a common protein partner. Experimental evidence indicates that for this specific partner, phosphorylation by c-Abl enhance... | |
medium_convergence_06036 | The pontine nuclear group and the salivatory nucleus share a common anatomical classification. Evidence regarding one such shared entity describes nuclei located in the basal pons, intermingled among descending cortical axons, which receive neocortical input and send axons across the midline to the contralateral cerebe... | hindbrain | Medium | convergence | {"qa_id":"medium_convergence_06036","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The pontine nuclear group and the salivatory nucleus share a common anatomical classification. Evidence regarding one such shared entity describes nuclei loc... | |
medium_convergence_06037 | WWP2 and NEDD4 both interact with a shared protein. Evidence indicates that for this specific shared entity, ubiquitination and PPXY motifs mediate its protein degradation, dictate its subcellular localization, and are required for its interaction with the NEDD4-family E3 ubiquitin ligase WWP2. Which cell type is this ... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06037","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WWP2 and NEDD4 both interact with a shared protein. Evidence indicates that for this specific shared entity, ubiquitination and PPXY motifs mediate its prote... | |
medium_convergence_06038 | COPS5 and MYC share multiple interacting partners. One such shared partner is supported by evidence stating: 'Fluorescence resonance energy transfer and co-immunoprecipitation studies revealed that a thioredoxin family protein and Jab1 colocalize and directly interact with each other.' Which disease is associated with ... | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06038","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and MYC share multiple interacting partners. One such shared partner is supported by evidence stating: 'Fluorescence resonance energy transfer and co-i... | |
medium_convergence_06039 | Both Human alphaherpesvirus 3 and Zaire ebolavirus are known to downregulate the expression of a specific gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene exhibits a log2 fold change of -1.386 and an adjusted p-value of 1.824e-07. Which protein is encoded by this gene? | CCAAT/enhancer-binding protein alpha | Medium | convergence | {"qa_id":"medium_convergence_06039","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zaire ebolavirus are known to downregulate the expression of a specific gene. Experimental data from a melanoma cell line s... | |
medium_convergence_06040 | CHEK2 and PPP2R1B share multiple interacting partners. One such partner is identified by evidence stating: 'In vitro GST-Chk2 pulldowns demonstrated that B'gamma isoforms bound to Chk2 with the strongest apparent affinity.' Which cellular component is this specific partner located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_06040","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK2 and PPP2R1B share multiple interacting partners. One such partner is identified by evidence stating: 'In vitro GST-Chk2 pulldowns demonstrated that B'g... | |
medium_convergence_06041 | STRA13 and FANCE each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'In normal cells, HA-tagged FANCE protein coimmunoprecipitates with FANCA, FANCC, and this shared partner but not with FANCD2.' Which disease is connected to this shared partner through genomic alter... | ovarian neoplasm | Medium | convergence | {"qa_id":"medium_convergence_06041","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STRA13 and FANCE each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'In normal cells, HA-tagged FANCE pr... | |
medium_convergence_06043 | KHDRBS1 and HSP90AA1 both interact with a shared protein. Evidence regarding this shared protein states: 'The SH3 domain of Bruton's tyrosine kinase interacts with Vav, Sam68 and EWS.' Which cell type is this shared protein enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_06043","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KHDRBS1 and HSP90AA1 both interact with a shared protein. Evidence regarding this shared protein states: 'The SH3 domain of Bruton's tyrosine kinase interact... | |
medium_convergence_06046 | BARD1 and HIST1H4A share multiple binding partners. One such shared partner is implicated in a study stating: 'Here we demonstrate that this link occurs through direct binding of a DNA damage response protein and Crb2 to histone H4.' Which disease is associated with this specific shared partner via genomic alterations? | lupus vulgaris | Medium | convergence | {"qa_id":"medium_convergence_06046","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BARD1 and HIST1H4A share multiple binding partners. One such shared partner is implicated in a study stating: 'Here we demonstrate that this link occurs thro... | |
medium_convergence_06047 | PRKAB1 and ATG101 both interact with a shared protein partner. Evidence regarding this partner states: 'In addition to binding of each noncatalytic subunit to the alpha subunit, the beta and gamma subunits bind to each other, likely resulting in a more stable heterotrimeric complex.' Which protein is encoded by the gen... | 5'-AMP-activated protein kinase subunit gamma-1 | Medium | convergence | {"qa_id":"medium_convergence_06047","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKAB1 and ATG101 both interact with a shared protein partner. Evidence regarding this partner states: 'In addition to binding of each noncatalytic subunit t... | |
medium_convergence_06048 | HDAC2 and LEF1 share multiple binding partners. One such partner is described in evidence stating: 'We show that TLE/Gro interacts with LEF-1 and Pan, and inhibits LEF-1:beta-catenin-dependent transcription.' Which disease is associated with this specific entity? | fibrosarcoma | Medium | convergence | {"qa_id":"medium_convergence_06048","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC2 and LEF1 share multiple binding partners. One such partner is described in evidence stating: 'We show that TLE/Gro interacts with LEF-1 and Pan, and in... | |
medium_convergence_06049 | The biological processes 'regulation of L-glutamate import across plasma membrane' and 'regulation of glycine import across plasma membrane' share a common parent process. Evidence regarding this shared process states: 'Any process that modulates the frequency, rate or extent of L-glutamate import into a cell.' Which b... | amino acid import across plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_06049","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'regulation of L-glutamate import across plasma membrane' and 'regulation of glycine import across plasma membrane' share a common p... | |
medium_convergence_06050 | Both Human polyomavirus 1 and Human immunodeficiency virus 1 are reported to upregulate a specific gene. In a study of renal epithelial cells (GSE135833), this gene exhibited a log2 fold change of approximately 1.29 and an adjusted p-value of 0.0195. Which cellular component is this gene located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_06050","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human polyomavirus 1 and Human immunodeficiency virus 1 are reported to upregulate a specific gene. In a study of renal epithelial cells (GSE135833), th... | |
medium_convergence_06052 | ERCC3 and RPS27A each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'This interaction is thought to be mediated through the specific affinity of this entity for the TFIIH subunits XPB and/or p62, which are essential for both basal transcription and nucleotide excis... | DNA repair protein complementing XP-C cells | Medium | convergence | {"qa_id":"medium_convergence_06052","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC3 and RPS27A each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'This interaction is thought to be... | |
medium_convergence_06053 | Human alphaherpesvirus 1 and Rift Valley fever phlebovirus both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.244 and an adjusted p-value of 0.005766. Which disease is associated with this gene through genomi... | brain cancer | Medium | convergence | {"qa_id":"medium_convergence_06053","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Rift Valley fever phlebovirus both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line... | |
medium_convergence_06054 | Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data from a study on hepatocytes (GSE135619) indicates that this gene exhibits a log2 fold change of approximately -1.296 and an adjusted p-value of 0.04032. Which prot... | Zinc finger protein 395 | Medium | convergence | {"qa_id":"medium_convergence_06054","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data ... | |
medium_convergence_06055 | CCDC22 and CUL1 share a common binding partner. Evidence indicates that this shared entity, also known as a specific F-box protein, functions as part of the SCF complex with Skp1 and Cullin1, specifically interacting with phosphorylated IkappaB and beta-catenin to target them for proteasome-dependent degradation. Which... | neurodevelopmental, jaw, eye, and digital syndrome | Medium | convergence | {"qa_id":"medium_convergence_06055","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCDC22 and CUL1 share a common binding partner. Evidence indicates that this shared entity, also known as a specific F-box protein, functions as part of the ... | |
medium_convergence_06056 | HDAC5 and AKT1 share multiple interacting partners. One such partner is implicated in a process where PTH treatment induces an association of AKT with the catalytic subunit of PP2A and increases its phosphatase activity. Which protein encodes this specific interacting partner? | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | Medium | convergence | {"qa_id":"medium_convergence_06056","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC5 and AKT1 share multiple interacting partners. One such partner is implicated in a process where PTH treatment induces an association of AKT with the ca... | |
medium_convergence_06057 | INO80 and ACTB both bind to a shared gene product. Evidence indicates that YY1 is tightly associated with the human ATP-dependent INO80-like chromatin-remodeling complex. Which gene interacts with this specific shared entity? | BRD3 | Medium | convergence | {"qa_id":"medium_convergence_06057","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"INO80 and ACTB both bind to a shared gene product. Evidence indicates that YY1 is tightly associated with the human ATP-dependent INO80-like chromatin-remode... | |
medium_convergence_06058 | CETN2 and CUL4B both interact with a specific protein complex component. Evidence indicates that this component is stabilized by CETN2 in cooperation with HR23B, which enhances its nucleotide excision repair (NER) activity in vitro. Which protein is encoded by the gene corresponding to this component? | DNA repair protein complementing XP-C cells | Medium | convergence | {"qa_id":"medium_convergence_06058","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CETN2 and CUL4B both interact with a specific protein complex component. Evidence indicates that this component is stabilized by CETN2 in cooperation with HR... | |
medium_convergence_06059 | GRB2 and JUN share multiple interacting partners. One such shared partner is described in evidence stating: 'The results demonstrate that ara-C also induces binding of SAP kinase to the SH2/SH3-containing adapter protein Grb2.' Which cell type is this shared partner enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_06059","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and JUN share multiple interacting partners. One such shared partner is described in evidence stating: 'The results demonstrate that ara-C also induces ... | |
medium_convergence_06060 | DCP1A and EXOSC5 share multiple binding partners. One shared partner is characterized by the following evidence: Mutation of six C-terminal lysines of DCP1a suppresses decapping activity and impairs the interaction with the mRNA decay factors DCP2, EDC4, and this shared partner, but not EDC3, thus remodeling P-body arc... | astrocytoma (excluding glioblastoma) | Medium | convergence | {"qa_id":"medium_convergence_06060","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCP1A and EXOSC5 share multiple binding partners. One shared partner is characterized by the following evidence: Mutation of six C-terminal lysines of DCP1a ... | |
medium_convergence_06061 | MYC and RPL11 share multiple interacting partners. One such partner is described in the following evidence: 'Here, we show that glutamate-rich WD40 repeat containing 1 physically and functionally interacts with RPL11.' Which disease is associated with this specific entity? | diarrhea 14, congenital | Medium | convergence | {"qa_id":"medium_convergence_06061","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and RPL11 share multiple interacting partners. One such partner is described in the following evidence: 'Here, we show that glutamate-rich WD40 repeat co... | |
medium_convergence_06062 | FAN1 and ATR both interact with a specific protein involved in the Fanconi anemia pathway. Evidence indicates that KIAA1018 is recruited to DNA damage sites through the interaction of its UBZ domain with the monoubiquitylated form of this protein. Which protein is encoded by the gene corresponding to this interaction p... | Fanconi anemia group D2 protein | Medium | convergence | {"qa_id":"medium_convergence_06062","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAN1 and ATR both interact with a specific protein involved in the Fanconi anemia pathway. Evidence indicates that KIAA1018 is recruited to DNA damage sites ... | |
medium_convergence_06064 | CNOT1 and CNOT7 share interaction partners. One such partner is MEX-3C, a canonical RNA-binding ubiquitin ligase that associates with cytoplasmic deadenylation complexes and ubiquitinates CNOT7 (also known as Caf1), the main catalytic subunit of the CCR4-NOT deadenylation machinery. Which protein is connected to MEX-3C... | RNA-binding E3 ubiquitin-protein ligase MEX3C | Medium | convergence | {"qa_id":"medium_convergence_06064","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CNOT1 and CNOT7 share interaction partners. One such partner is MEX-3C, a canonical RNA-binding ubiquitin ligase that associates with cytoplasmic deadenylati... | |
medium_convergence_06065 | Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) shows a log2 fold change of approximately 1.154 and an adjusted p-value of 0.02671. Which protein is encoded by this gene? | Neuroserpin | Medium | convergence | {"qa_id":"medium_convergence_06065","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) shows a ... | |
medium_convergence_06066 | CRYZ and ETFRF1 share multiple interacting partners. One such shared partner is implicated in a study stating: 'We likewise discovered that LYRM5 interacts with and deflavinates the electron-transferring flavoprotein that shuttles electrons to coenzyme Q (CoQ).' Which protein is encoded by this shared partner? | Electron transfer flavoprotein subunit beta | Medium | convergence | {"qa_id":"medium_convergence_06066","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRYZ and ETFRF1 share multiple interacting partners. One such shared partner is implicated in a study stating: 'We likewise discovered that LYRM5 interacts w... | |
medium_convergence_06067 | Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus upregulate a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) reports a log2 fold change of approximately 1.074 and an adjusted p-value of 0.0325. What molecular function is enabled by this gene? | RNA binding | Medium | convergence | {"qa_id":"medium_convergence_06067","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus upregulate a specific gene. Experimental data for this gene in hepatocytes (f... | |
medium_convergence_06068 | CBL and CD247 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'In addition, we demonstrate that the SH2-SH3-SH3 adaptor protein CrkL is tyrosine-phosphorylated in an IL-2-dependent manner and, via its SH2 domain, associates with a large proportion of phosphory... | Adapter molecule crk | Medium | convergence | {"qa_id":"medium_convergence_06068","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBL and CD247 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'In addition, we demonstrate that t... | |
medium_convergence_06069 | AP2A2 and DNAJC6 both interact with a specific shared protein. Evidence regarding this shared entity states: 'The central region of epsin binds AP-2 and its carboxy-terminal region binds Eps15.' Which gene encodes this shared protein? | Epsin-1 | Medium | convergence | {"qa_id":"medium_convergence_06069","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP2A2 and DNAJC6 both interact with a specific shared protein. Evidence regarding this shared entity states: 'The central region of epsin binds AP-2 and its ... | |
medium_convergence_06070 | HBP1 and YPEL5 share common interacting partners. One such shared partner cooperates with RanBP9 to ubiquitinate HBP1 in vitro, a reaction in which GID4 is dispensable. Which protein is encoded by this shared interacting partner? | WD repeat-containing protein 26 | Medium | convergence | {"qa_id":"medium_convergence_06070","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HBP1 and YPEL5 share common interacting partners. One such shared partner cooperates with RanBP9 to ubiquitinate HBP1 in vitro, a reaction in which GID4 is d... | |
medium_convergence_06071 | AMOT and AMOTL1 both interact with a specific shared protein partner. Experimental evidence demonstrates that the cellular protein Angiomotin (AMOT) can bind both this shared partner and HIV-1 Gag. Which protein is encoded by the gene corresponding to this shared partner? | E3 ubiquitin-protein ligase NEDD4-like | Medium | convergence | {"qa_id":"medium_convergence_06071","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AMOT and AMOTL1 both interact with a specific shared protein partner. Experimental evidence demonstrates that the cellular protein Angiomotin (AMOT) can bind... | |
medium_convergence_06072 | CENPA and CENPP each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosomal CENP-A complexes to identify direct CENP-A partners involved in such a mechanism and identified this protein.' Which disease is associated with that specific ent... | astrocytoma (excluding glioblastoma) | Medium | convergence | {"qa_id":"medium_convergence_06072","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and CENPP each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosoma... | |
medium_convergence_06073 | Hepacivirus C and Dengue virus both downregulate a specific gene. Experimental data for this gene shows a log2 fold change of approximately -1.22 and an adjusted p-value of approximately 0.0069. Which disease is associated with this gene? | lymphoma | Medium | convergence | {"qa_id":"medium_convergence_06073","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Dengue virus both downregulate a specific gene. Experimental data for this gene shows a log2 fold change of approximately -1.22 and an adju... | |
medium_convergence_06074 | AKAP9 and CDK1 both interact with a shared protein. Evidence regarding this shared protein states: 'Furthermore, the CM2-like motif is essential for the association of the centrosome-targeting domain to pericentrin and AKAP450.' Which cell type is this shared protein enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_06074","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP9 and CDK1 both interact with a shared protein. Evidence regarding this shared protein states: 'Furthermore, the CM2-like motif is essential for the asso... | |
medium_convergence_06076 | TRIM28 and CBX3 share a common interacting partner. Evidence indicates that this shared partner is a SUMO/Sentrin/Smt3-specific peptidase that interacts with the chromatin repressive KRAB-associated protein 1 (KAP1) through heterochromatin protein 1 alpha (HP1α). Which protein is encoded by this shared partner? | Sentrin-specific protease 7 | Medium | convergence | {"qa_id":"medium_convergence_06076","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and CBX3 share a common interacting partner. Evidence indicates that this shared partner is a SUMO/Sentrin/Smt3-specific peptidase that interacts with... | |
medium_convergence_06077 | CTBP2 and HIVEP1 share multiple interacting partners. One such shared partner is described in evidence stating: 'We show here that a Krüppel-like factor also recruits the four and a half LIM domain protein FHL3.' Which protein is encoded by this shared partner? | Krueppel-like factor 3 | Medium | convergence | {"qa_id":"medium_convergence_06077","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP2 and HIVEP1 share multiple interacting partners. One such shared partner is described in evidence stating: 'We show here that a Krüppel-like factor also... | |
medium_convergence_06078 | Both the serous cell of the epithelium of the terminal bronchiole and the serous cell of the epithelium of the lobular bronchiole share a common parent cell type. Evidence indicates that this shared entity is a serous-secreting cell located within the epithelium of the terminal bronchiole. Which anatomical structure is... | tracheobronchial tree | Medium | convergence | {"qa_id":"medium_convergence_06078","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the serous cell of the epithelium of the terminal bronchiole and the serous cell of the epithelium of the lobular bronchiole share a common parent cell ... | |
medium_convergence_06079 | DSTN and ACTBL2 both interact with a specific protein. Evidence regarding this shared interaction partner indicates that it binds to G-actin at pH 8 with a 1:1 stoichiometry and a dissociation constant (Kd) of approximately 0.2 microM, thereby sequestering monomers and preventing polymerization. Which protein is encode... | Actin, alpha skeletal muscle | Medium | convergence | {"qa_id":"medium_convergence_06079","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DSTN and ACTBL2 both interact with a specific protein. Evidence regarding this shared interaction partner indicates that it binds to G-actin at pH 8 with a 1... | |
medium_convergence_06080 | CTNNB1 and AMOT share multiple interacting partners. One such partner is identified in the following evidence: 'We identified beta-catenin, a component of adherens junctions, as a substrate of a protein tyrosine phosphatase by a 'substrate trapping' approach and by in vitro dephosphorylation with recombinant protein ty... | lymphedema-posterior choanal atresia syndrome | Medium | convergence | {"qa_id":"medium_convergence_06080","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and AMOT share multiple interacting partners. One such partner is identified in the following evidence: 'We identified beta-catenin, a component of ad... | |
medium_convergence_06082 | DLG2 and GRIN2B both interact with a specific protein that functions as a Ca(2+)/calmodulin-dependent Ras-guanine-nucleotide-releasing factor. Evidence indicates that the NR2B subunit of the NMDAR, but not the NR2A or NR1 subunits, interacts with this protein in vivo and in vitro. What molecular function is enabled by ... | guanyl-nucleotide exchange factor activity | Medium | convergence | {"qa_id":"medium_convergence_06082","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG2 and GRIN2B both interact with a specific protein that functions as a Ca(2+)/calmodulin-dependent Ras-guanine-nucleotide-releasing factor. Evidence indic... | |
medium_convergence_06083 | Both Human polyomavirus 1 and Influenza A virus are reported to upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) show a log2 fold change of approximately 1.94 and an adjusted p-value of approximately 0.005. Which protein is encoded by this gene? | Glycerophosphocholine phosphodiesterase GPCPD1 | Medium | convergence | {"qa_id":"medium_convergence_06083","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human polyomavirus 1 and Influenza A virus are reported to upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study ... | |
medium_convergence_06084 | JUN and MYC both interact with a shared protein entity. Experimental evidence indicates that the C-terminal region of this shared entity directly interacts with SRF, the AP-1 components c-Jun and c-Fos, and the NF-kappaB components p50 and p65, as demonstrated by yeast and mammalian two-hybrid tests as well as glutathi... | Nuclear receptor corepressor 2 | Medium | convergence | {"qa_id":"medium_convergence_06084","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"JUN and MYC both interact with a shared protein entity. Experimental evidence indicates that the C-terminal region of this shared entity directly interacts w... | |
medium_convergence_06085 | EGFR and RHOA both interact with a shared protein. Evidence indicates that this shared protein coprecipitated with activated epidermal growth factor and platelet-derived growth factor (PDGF) receptors, and that phosphorylated tyrosine residues on the PDGF receptor mediated its tyrosine phosphorylation. Which protein is... | Guanine nucleotide exchange factor VAV2 | Medium | convergence | {"qa_id":"medium_convergence_06085","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and RHOA both interact with a shared protein. Evidence indicates that this shared protein coprecipitated with activated epidermal growth factor and plat... | |
medium_convergence_06086 | The biological processes 'regulation of prostatic bud formation' and 'regulation of branching involved in salivary gland morphogenesis' share a common parent process. Evidence regarding this shared process states: 'Any process that modulates the rate, frequency, or extent of prostatic bud formation, the morphogenetic p... | morphogenesis of a branching structure | Medium | convergence | {"qa_id":"medium_convergence_06086","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'regulation of prostatic bud formation' and 'regulation of branching involved in salivary gland morphogenesis' share a common parent... | |
medium_convergence_06087 | Both Human alphaherpesvirus 1 and Hepacivirus C are known to downregulate a specific shared gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of -1.455 and an adjusted p-value of 0.002513. Which disease is associated with this gene through genomic alter... | hypertensive disorder | Medium | convergence | {"qa_id":"medium_convergence_06087","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Hepacivirus C are known to downregulate a specific shared gene. Experimental data for this gene in a monocytic leukemia cel... | |
medium_convergence_06088 | Pemetrexed and Mycophenolic acid share a common interacting drug. Evidence indicates that Basiliximab, this shared drug, cilastatin sodium, and sex were associated with mycophenolate mofetil AUC-MPA at 7 days. Which disease is this shared drug indicated for? | endocarditis | Medium | convergence | {"qa_id":"medium_convergence_06088","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Pemetrexed and Mycophenolic acid share a common interacting drug. Evidence indicates that Basiliximab, this shared drug, cilastatin sodium, and sex were asso... | |
medium_convergence_06089 | Hepacivirus C and Zaire ebolavirus both upregulate a specific gene. Evidence for this shared target reports a log2 fold change of 1.806 and an adjusted p-value of 0.02377. Which protein is encoded by this gene? | Caveolin-2 | Medium | convergence | {"qa_id":"medium_convergence_06089","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Zaire ebolavirus both upregulate a specific gene. Evidence for this shared target reports a log2 fold change of 1.806 and an adjusted p-val... | |
medium_convergence_06090 | BMP2 and BMP5 both interact with a specific receptor protein. Experimental evidence regarding this receptor demonstrates the existence of preexisting heteromeric (BR-II/BR-Ia and BR-II/BR-Ib) and homomeric (BR-II/BR-II, BR-Ia/BR-Ia, BR-Ib/BR-Ib, and BR-Ia/BR-Ib) oligomers in live cells in the absence of ligand, as show... | Bone morphogenetic protein receptor type-1B | Medium | convergence | {"qa_id":"medium_convergence_06090","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP2 and BMP5 both interact with a specific receptor protein. Experimental evidence regarding this receptor demonstrates the existence of preexisting heterom... | |
medium_convergence_06091 | YAP1 and COPS5 share multiple interacting partners. One such partner is described by the following evidence: 'Mechanistically, we found that CSN5 directly bound this protein and decreased its ubiquitination to enhance the protein stability of this protein in RCC cells.' Which cellular component is this protein located ... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_06091","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and COPS5 share multiple interacting partners. One such partner is described by the following evidence: 'Mechanistically, we found that CSN5 directly bo... |
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