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medium_convergence_06323 | CLU and HSP90AA1 share multiple interacting partners. One such shared partner is known to interact with both type I (RI) and type II (RII) TGF-beta receptors, but does not interact with the epidermal growth factor (EGF) receptor. Which cell type is enriched for this specific shared partner? | basophil | Medium | convergence | {"qa_id":"medium_convergence_06323","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLU and HSP90AA1 share multiple interacting partners. One such shared partner is known to interact with both type I (RI) and type II (RII) TGF-beta receptors... | |
medium_convergence_06324 | EGFR and EPHA2 share a common interaction partner. Evidence regarding this shared partner states: 'Using glutathione S-transferase fusion Proteins, it was demonstrated that the shared partner bound to activated Eck receptor tyrosine kinase.' Which protein is encoded by this shared interaction partner? | Src-like-adapter | Medium | convergence | {"qa_id":"medium_convergence_06324","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and EPHA2 share a common interaction partner. Evidence regarding this shared partner states: 'Using glutathione S-transferase fusion Proteins, it was de... | |
medium_convergence_06325 | Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for this gene in a study (GSE135833) reports a log2 fold change of approximately 3.13 and an adjusted p-value of approximately 0.023. Which cell type is this gene enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_06325","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for this gene in a study (GSE135833) reports a log2 fold ch... | |
medium_convergence_06326 | FBXO45 and MYCBP2 both interact with a shared gene product. Evidence for one such shared partner indicates a direct interaction with FBXO45, whereas FBXO45 is required to mediate the indirect binding of this partner to SKP1. Which cell type is enriched for this specific shared partner? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06326","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXO45 and MYCBP2 both interact with a shared gene product. Evidence for one such shared partner indicates a direct interaction with FBXO45, whereas FBXO45 i... | |
medium_convergence_06327 | Both West Nile virus and Influenza A virus are known to upregulate a specific shared gene. Experimental data for this gene in monocyte-derived dendritic cells (from study GSE136342) reports a log2 fold change of approximately 1.029 and an adjusted p-value of 1.313e-05. Which cellular component is this gene located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_06327","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Influenza A virus are known to upregulate a specific shared gene. Experimental data for this gene in monocyte-derived dendritic cell... | |
medium_convergence_06328 | Human gammaherpesvirus 4 and Human immunodeficiency virus 1 both downregulate a specific gene. Experimental data for this gene in gamma delta T-lymphocytes (from study GSE13906) shows a log2 fold change of -1.968 and an adjusted p-value of 0.03858. Which protein is encoded by this gene? | Arylsulfatase J | Medium | convergence | {"qa_id":"medium_convergence_06328","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human gammaherpesvirus 4 and Human immunodeficiency virus 1 both downregulate a specific gene. Experimental data for this gene in gamma delta T-lymphocytes (... | |
medium_convergence_06329 | RPA1 and SMARCB1 both interact with a specific shared protein. Experimental evidence indicates that RPA physically interacts with this protein to form RPA-protein-H3.3 complexes and co-localizes with it and H3.3 at gene promoters and enhancers. Which protein is encoded by the gene corresponding to this shared entity? | Protein HIRA | Medium | convergence | {"qa_id":"medium_convergence_06329","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPA1 and SMARCB1 both interact with a specific shared protein. Experimental evidence indicates that RPA physically interacts with this protein to form RPA-pr... | |
medium_convergence_06330 | MYC and RELA both interact with a shared protein. Evidence indicates that RFC (p140) interacts with this shared entity both in vitro and in vivo and stimulates its transactivation. Which protein is encoded by this shared entity? | Replication factor C subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_06330","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and RELA both interact with a shared protein. Evidence indicates that RFC (p140) interacts with this shared entity both in vitro and in vivo and stimulat... | |
medium_convergence_06331 | Denileukin diftitox and Etanercept share a common drug interaction partner. Clinical evidence indicates that immunosuppression was induced with anti-CD25 (Daclizumab), alone or in association with anti-tumor necrosis factor alpha (TNF-α) treatments, or with anti-CD52 (the shared entity) in association with anti-TNF-α t... | B-cell chronic lymphocytic leukemia | Medium | convergence | {"qa_id":"medium_convergence_06331","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Denileukin diftitox and Etanercept share a common drug interaction partner. Clinical evidence indicates that immunosuppression was induced with anti-CD25 (Da... | |
medium_convergence_06332 | COPS5 and COPS4 both interact with a shared protein. Evidence regarding this shared protein states: 'We demonstrated that the C-terminal half of the shared protein encompassing the PCI domain is responsible for interaction with CSN2, CSN3, and CSN4 subunits and is required for incorporation of the subunit into the comp... | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_06332","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and COPS4 both interact with a shared protein. Evidence regarding this shared protein states: 'We demonstrated that the C-terminal half of the shared p... | |
medium_convergence_06333 | Human polyomavirus 1 and Measles morbillivirus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 1.026 and an adjusted p-value of 0.04747. Which disease is associated with this gene? | neurofibrosarcoma | Medium | convergence | {"qa_id":"medium_convergence_06333","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Measles morbillivirus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) r... | |
medium_convergence_06334 | Both Human alphaherpesvirus 3 and Zika virus are known to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of approximately -1.278 and an adjusted p-value of 6.018e-07. Which disease is associated with this gene as a biomarker? | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_06334","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zika virus are known to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136... | |
medium_convergence_06335 | RUVBL2 and HDAC1 share multiple interacting partners. One such partner is implicated in evidence stating that 'Nondenaturing co-IP assays indicate that nuclear Bcl-3 associates with STAT-1 and histone deacetylase 1 (HDAC-1), increasing HDAC-1 recruitment to the IL-8 promoter.' Which protein is encoded by the gene corre... | B-cell lymphoma 3 protein | Medium | convergence | {"qa_id":"medium_convergence_06335","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RUVBL2 and HDAC1 share multiple interacting partners. One such partner is implicated in evidence stating that 'Nondenaturing co-IP assays indicate that nucle... | |
medium_convergence_06336 | Glimepiride and Liothyronine share a common interacting drug. Evidence regarding this shared entity states: 'Pinacidil induced a dose-dependent relaxation of the shared drug preconstricted mesenteric and renal arteries ... Schild plot analysis of pinacidil relaxation curves in mesenteric arteries in the presence of sul... | priapism | Medium | convergence | {"qa_id":"medium_convergence_06336","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Glimepiride and Liothyronine share a common interacting drug. Evidence regarding this shared entity states: 'Pinacidil induced a dose-dependent relaxation of... | |
medium_convergence_06337 | FBXW11 and CUL1 both interact with a specific shared protein. Evidence indicates that TGF-beta-induced ubiquitination of this protein is associated with its phosphorylation at the beta-TrCP docking site (DS82G motif) and its physical association with Smad3 and beta-TrCP. Which protein is encoded by the gene correspondi... | M-phase inducer phosphatase 1 | Medium | convergence | {"qa_id":"medium_convergence_06337","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW11 and CUL1 both interact with a specific shared protein. Evidence indicates that TGF-beta-induced ubiquitination of this protein is associated with its ... | |
medium_convergence_06338 | Both Human immunodeficiency virus 1 and Dengue virus are reported to upregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) indicates a log2 fold change of approximately 1.383 and an adjusted p-value of 0.0008909. Which protein does this upregulated gene product interact with? | BIRC6 | Medium | convergence | {"qa_id":"medium_convergence_06338","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are reported to upregulate a specific gene. Experimental data for this gene in macrophages (from study G... | |
medium_convergence_06339 | ARAF and BRAF both interact with a shared protein partner. Evidence indicates that in yeast two-hybrid screening using a specific MAP2K family member as bait, A-Raf was identified as a novel partner interacting with it. Which protein is encoded by this shared partner? | Dual specificity mitogen-activated protein kinase kinase 2 | Medium | convergence | {"qa_id":"medium_convergence_06339","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARAF and BRAF both interact with a shared protein partner. Evidence indicates that in yeast two-hybrid screening using a specific MAP2K family member as bait... | |
medium_convergence_06340 | Histamine secretion by mast cells and histamine secretion by platelets are both subtypes of two distinct biological processes. One of these shared processes is defined by the evidence statement: 'The regulated release of histamine by a mast cell or group of mast cells.' Which biological process is this shared entity a ... | histamine production involved in inflammatory response | Medium | convergence | {"qa_id":"medium_convergence_06340","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Histamine secretion by mast cells and histamine secretion by platelets are both subtypes of two distinct biological processes. One of these shared processes ... | |
medium_convergence_06341 | VPS26B and VPS29 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Direct binding of the retromer component VPS29 to this entity could be titrated out by LC3, indicating a molecular switch between endosomes and autophagy.' Which protein is connected to that entity thr... | TBC1 domain family member 5 | Medium | convergence | {"qa_id":"medium_convergence_06341","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VPS26B and VPS29 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Direct binding of the retromer compone... | |
medium_convergence_06342 | CSTF1 and AQR both interact with a shared protein partner. Evidence regarding one such partner states: 'In [a protein encoded by CSTF2], a small region, highly conserved in metazoa, is responsible for interactions with two proteins, CstF-77 and symplekin, a nuclear protein of previously unknown function.' Which protein... | Cleavage stimulation factor subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_06342","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSTF1 and AQR both interact with a shared protein partner. Evidence regarding one such partner states: 'In [a protein encoded by CSTF2], a small region, high... | |
medium_convergence_06343 | CBX3 and CBX5 both interact with a shared protein. Evidence regarding this shared protein states: 'In this study, we show that the human Mis14 (hMis14; also called hNsl1 and DC8) subunit of the heterotetrameric hMis12 complex is involved in inner centromere architecture through a direct interaction with HP1 (heterochro... | attachment of spindle microtubules to kinetochore | Medium | convergence | {"qa_id":"medium_convergence_06343","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and CBX5 both interact with a shared protein. Evidence regarding this shared protein states: 'In this study, we show that the human Mis14 (hMis14; also ... | |
medium_convergence_06344 | EP300 and MYC share multiple binding partners. One such partner is a component of the NF-Y complex that interacts with p300 in vivo and serves as a target for acetylation by p300. Specifically, the NFY/B subunit of this complex interacts with the central segment of p300. Which protein is encoded by this specific subuni... | Nuclear transcription factor Y subunit beta | Medium | convergence | {"qa_id":"medium_convergence_06344","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and MYC share multiple binding partners. One such partner is a component of the NF-Y complex that interacts with p300 in vivo and serves as a target fo... | |
medium_convergence_06345 | H3-3A and MYB each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In addition, three corepressors (Ski, N-CoR, and mSin3A) bind to the DNA-binding domain of c-Myb together with TIF1beta and recruit the histone deacetylase complex to c-Myb.' Which protein is connected to that... | Paired amphipathic helix protein Sin3a | Medium | convergence | {"qa_id":"medium_convergence_06345","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H3-3A and MYB each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In addition, three corepressors (Ski, N-CoR, a... | |
medium_convergence_06346 | MLST8 and LAMTOR3 each interact with more than one shared protein partner. Experimental evidence involving size exclusion chromatography and coimmunoprecipitation of epitope-tagged subunits indicates that the major insulin-responsive form is a dimeric complex (mTORC1), which contains two heterotrimers composed of the s... | Serine/threonine-protein kinase mTOR | Medium | convergence | {"qa_id":"medium_convergence_06346","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MLST8 and LAMTOR3 each interact with more than one shared protein partner. Experimental evidence involving size exclusion chromatography and coimmunoprecipit... | |
medium_convergence_06347 | CDK2 and EP300 share multiple interaction partners. One such partner forms a stable complex with CDK2, to which Noxa binds to facilitate the phosphorylation of this partner. Which disease is associated with this specific partner through genomic alterations? | follicular lymphoma | Medium | convergence | {"qa_id":"medium_convergence_06347","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and EP300 share multiple interaction partners. One such partner forms a stable complex with CDK2, to which Noxa binds to facilitate the phosphorylation ... | |
medium_convergence_06348 | UBR5 and RPA3 both interact with a shared protein. Evidence indicates that this shared protein, along with BuGZ, interacts with either importin-β or an E3 ubiquitin ligase (specifically Ubr5). Which protein is encoded by this shared entity? | Mitotic checkpoint protein BUB3 | Medium | convergence | {"qa_id":"medium_convergence_06348","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBR5 and RPA3 both interact with a shared protein. Evidence indicates that this shared protein, along with BuGZ, interacts with either importin-β or an E3 ub... | |
medium_convergence_06349 | FANCD2 and MLH1 each interact with more than one shared gene product. Evidence concerning one shared entity reports that the MRN complex component encoded by that entity coimmunoprecipitated with the mismatch repair protein MLH1 specifically in response to temozolomide treatment. Which protein is encoded by that entity... | Nibrin | Medium | convergence | {"qa_id":"medium_convergence_06349","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCD2 and MLH1 each interact with more than one shared gene product. Evidence concerning one shared entity reports that the MRN complex component encoded by... | |
medium_convergence_06350 | Cardiovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately 3.33 and an adjusted p-value of 0.049. Which disease is associated with this gene as a biomarker? | gastric carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06350","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cardiovirus A and Zaire ebolavirus both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) ... | |
medium_convergence_06351 | LEF1 and HDAC8 both interact with a shared protein. Evidence regarding this shared entity states: 'We show that TLE/Gro interacts with LEF-1 and Pan, and inhibits LEF-1:beta-catenin-dependent transcription.' Which disease is associated with this entity? | fibrosarcoma | Medium | convergence | {"qa_id":"medium_convergence_06351","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LEF1 and HDAC8 both interact with a shared protein. Evidence regarding this shared entity states: 'We show that TLE/Gro interacts with LEF-1 and Pan, and inh... | |
medium_convergence_06352 | Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicates that this gene has a log2 fold change of approximately 1.060 and an adjusted p-value of 0.02297. Which protein is encoded by this gene? | Mitogen-activated protein kinase kinase kinase kinase 4 | Medium | convergence | {"qa_id":"medium_convergence_06352","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicates that th... | |
medium_convergence_06353 | KRAS and RAF1 both interact with a specific shared protein. Evidence indicates that this protein binds to RAF1 through its carboxy-terminal cysteine-rich domain, and this binding is necessary for the inhibitory activity of the protein. Which protein is encoded by the gene corresponding to this shared entity? | Protein sprouty homolog 4 | Medium | convergence | {"qa_id":"medium_convergence_06353","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRAS and RAF1 both interact with a specific shared protein. Evidence indicates that this protein binds to RAF1 through its carboxy-terminal cysteine-rich dom... | |
medium_convergence_06354 | AKT1 and HRAS each share a binding partner with another gene. Evidence concerning one such shared entity states that Akt (protein kinase B) interacted with Raf and phosphorylated this protein at a highly conserved serine residue in its regulatory domain in vivo. Which protein is encoded by that shared entity? | RAF proto-oncogene serine/threonine-protein kinase | Medium | convergence | {"qa_id":"medium_convergence_06354","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and HRAS each share a binding partner with another gene. Evidence concerning one such shared entity states that Akt (protein kinase B) interacted with R... | |
medium_convergence_06356 | FANCF and ATRIP both bind to a shared protein. Evidence indicates that MM1 interacts with the Fanconi anemia (FA) core complex by binding to this shared protein, whereas MM2 interacts with RM1 and topoisomerase IIIalpha, which are components of the BLM-SLX4 (BS) complex. Which gene does this shared protein interact wit... | TELO2 | Medium | convergence | {"qa_id":"medium_convergence_06356","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCF and ATRIP both bind to a shared protein. Evidence indicates that MM1 interacts with the Fanconi anemia (FA) core complex by binding to this shared prot... | |
medium_convergence_06357 | AMOTL1 and EGFR share common interaction partners. One such partner is an E3 ubiquitin ligase whose WW domain binds to EGFR, promoting ubiquitination at lysine 716 and subsequent degradation of EGFR. Which protein is encoded by the gene corresponding to this E3 ubiquitin ligase? | E3 ubiquitin-protein ligase NEDD4-like | Medium | convergence | {"qa_id":"medium_convergence_06357","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AMOTL1 and EGFR share common interaction partners. One such partner is an E3 ubiquitin ligase whose WW domain binds to EGFR, promoting ubiquitination at lysi... | |
medium_convergence_06358 | PPP2CA and PPP2R1A share multiple interacting partners. One such partner is described as binding to B56 subunits and pERK independently, enhancing B56 phosphorylation by ERK at a conserved Ser/Pro site within the complex, and triggering dissociation from the catalytic subunit. Which cell type is this specific partner e... | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_06358","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP2CA and PPP2R1A share multiple interacting partners. One such partner is described as binding to B56 subunits and pERK independently, enhancing B56 phosph... | |
medium_convergence_06359 | Hydrocortisone and Dexamethasone share a common drug interaction partner. Evidence indicates that treatment with 4-PBA decreased the expression levels of ERS-related proteins. Which drug is this shared interaction partner? | Deflazacort | Medium | convergence | {"qa_id":"medium_convergence_06359","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hydrocortisone and Dexamethasone share a common drug interaction partner. Evidence indicates that treatment with 4-PBA decreased the expression levels of ERS... | |
medium_convergence_06361 | Vaccinia virus and Dengue virus both upregulate a specific gene in cervical adenocarcinoma cells. Experimental data for this gene shows a log2 fold change of approximately 3.20 and an adjusted p-value of approximately 6.70e-10. Which biological process is this gene involved in? | nucleobase-containing compound metabolic process | Medium | convergence | {"qa_id":"medium_convergence_06361","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Dengue virus both upregulate a specific gene in cervical adenocarcinoma cells. Experimental data for this gene shows a log2 fold change of... | |
medium_convergence_06362 | DNM2 and FLT1 both interact with a common protein partner. Contextual evidence states: 'Furthermore, the VEGF/PGF heterodimer activated intramolecular VEGF receptor cross talk through formation of [VEGFR2]/Flt1 heterodimers.' Which protein is encoded by the gene corresponding to the partner that forms heterodimers with... | Vascular endothelial growth factor receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_06362","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNM2 and FLT1 both interact with a common protein partner. Contextual evidence states: 'Furthermore, the VEGF/PGF heterodimer activated intramolecular VEGF r... | |
medium_convergence_06363 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhibited a log2 fold change of approximately -1.073 and an adjusted p-value of 0.003982. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_06363","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhi... | |
medium_convergence_06364 | Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately -1.600 and an adjusted p-value of 0.0002486. Which disease is associated with this gene through genomic alterations? | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_06364","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both downregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports... | |
medium_convergence_06365 | MICU1 and C2orf47 are both associated with multiple shared biological processes. One of these shared processes involves an entity that is required to preserve normal mitochondrial calcium concentration ([Ca2+](m)) under basal conditions. Which biological process is this entity connected to via an 'is a' relationship? | intracellular calcium ion homeostasis | Medium | convergence | {"qa_id":"medium_convergence_06365","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MICU1 and C2orf47 are both associated with multiple shared biological processes. One of these shared processes involves an entity that is required to preserv... | |
medium_convergence_06366 | SMAD1 and RPS27A share a common binding partner. Experimental evidence indicates that this shared partner interacts with receptor-activated Smads (R-Smads), specifically Smad1, Smad2, and Smad3, but does not interact with Smad4. Which protein is encoded by the gene corresponding to this shared binding partner? | E3 ubiquitin-protein ligase SMURF2 | Medium | convergence | {"qa_id":"medium_convergence_06366","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD1 and RPS27A share a common binding partner. Experimental evidence indicates that this shared partner interacts with receptor-activated Smads (R-Smads), ... | |
medium_convergence_06367 | NR3C1 and PRKN share common interacting partners. One such shared partner is identified by evidence stating that 'Mammalian two-hybrid assay and glutathione S-transferase pull-down assay revealed the direct association between the shared partner and the GR DBD.' Which gene does this shared partner bind to? | TXNIP | Medium | convergence | {"qa_id":"medium_convergence_06367","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NR3C1 and PRKN share common interacting partners. One such shared partner is identified by evidence stating that 'Mammalian two-hybrid assay and glutathione ... | |
medium_convergence_06368 | TNK2 and SH3KBP1 both interact with a shared protein entity. Evidence regarding this entity states: 'We demonstrate ACK binds to all five PI3K regulatory subunit isoforms and directly phosphorylates the alpha, beta, 50-alpha, and 55-alpha isoforms on Tyr607 (or analogous residues).' Which protein is encoded by the gene... | Phosphatidylinositol 3-kinase regulatory subunit alpha | Medium | convergence | {"qa_id":"medium_convergence_06368","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TNK2 and SH3KBP1 both interact with a shared protein entity. Evidence regarding this entity states: 'We demonstrate ACK binds to all five PI3K regulatory sub... | |
medium_convergence_06369 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific gene. Experimental data from a study on lung fibroblast cell lines (GSE120891) indicates that for one such shared target, the log2 fold change is approximately 3.35 and the adjusted p-value is approx... | Receptor-type tyrosine-protein phosphatase-like N | Medium | convergence | {"qa_id":"medium_convergence_06369","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific gene. Experimental data from a study... | |
medium_convergence_06370 | ACVR1C and ACVR2A both interact with a specific ligand. Evidence regarding this ligand states: 'We hypothesized that, in addition to its canonical receptor ACVR2, activin A might similarly bind and signal via BMPR2.' Which protein product is encoded by the gene corresponding to this ligand? | Inhibin beta A chain | Medium | convergence | {"qa_id":"medium_convergence_06370","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACVR1C and ACVR2A both interact with a specific ligand. Evidence regarding this ligand states: 'We hypothesized that, in addition to its canonical receptor A... | |
medium_convergence_06371 | ERBB4 and ANLN both interact with a shared protein. Evidence regarding one such shared partner states: 'Using the yeast two-hybrid system, we found that the C-terminal region of ErbB-4 interacts with the three related membrane-associated guanylate kinases (MAGUKs) PSD-95/SAP90, PSD-93/chapsyn-110, and SAP 102, which ha... | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_06371","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB4 and ANLN both interact with a shared protein. Evidence regarding one such shared partner states: 'Using the yeast two-hybrid system, we found that the ... | |
medium_convergence_06373 | CENPA and CENPQ each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosomal CENP-A complexes to identify direct CENP-A partners involved in such a mechanism and identified this protein.' Which protein is encoded by the gene corresponding... | Holliday junction recognition protein | Medium | convergence | {"qa_id":"medium_convergence_06373","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and CENPQ each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosoma... | |
medium_convergence_06374 | Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific shared gene. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.97 and an adjusted p-value of approximately 0.0078. Which disease is connected to this gene through genom... | lymphoma, non-Hodgkin, familial | Medium | convergence | {"qa_id":"medium_convergence_06374","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific shared gene. Evidence for this gene in a monocytic leukemia cell line (study... | |
medium_convergence_06375 | PRKN and PDPK1 share multiple interacting partners. Experimental evidence from BioGRID, utilizing Affinity Capture-Western and Two-hybrid assays, identifies PKC-zeta, PKC-delta, and PRK2 as interactors of PDK1. Which protein, among the shared interactors of PRKN and PDPK1, is supported by this specific evidence and is ... | Protein kinase C delta type | Medium | convergence | {"qa_id":"medium_convergence_06375","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and PDPK1 share multiple interacting partners. Experimental evidence from BioGRID, utilizing Affinity Capture-Western and Two-hybrid assays, identifies ... | |
medium_convergence_06376 | DAXX and LMNA share multiple interacting partners. One such shared partner is described in experimental evidence as a chromatin-associated protein that associates with histone deacetylase II and core histones (H2A, H2B, H3, and H4), and is reported to change the topology of DNA in chromatin in vitro. Which disease is c... | urinary bladder neoplasm | Medium | convergence | {"qa_id":"medium_convergence_06376","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAXX and LMNA share multiple interacting partners. One such shared partner is described in experimental evidence as a chromatin-associated protein that assoc... | |
medium_convergence_06377 | Human alphaherpesvirus 1 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.95 and an adjusted p-value of approximately 0.0063. Which protein is encoded by this gene? | Dehydrogenase/reductase SDR family member 13 | Medium | convergence | {"qa_id":"medium_convergence_06377","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966... | |
medium_convergence_06378 | DCTN1 and MYC both interact with a specific shared protein. Experimental evidence indicates that upregulation of this shared protein increases its binding to c-Myc and activates c-Myc, subsequently inducing the expression of CCND1/CDK4 and promoting glioma cell temozolomide resistance and proliferation. Which protein i... | Nucleosome assembly protein 1-like 1 | Medium | convergence | {"qa_id":"medium_convergence_06378","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCTN1 and MYC both interact with a specific shared protein. Experimental evidence indicates that upregulation of this shared protein increases its binding to... | |
medium_convergence_06379 | Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) reports a log2 fold change of approximately -1.017 and an adjusted p-value of 0.0003694. Which disease is linked to this gene as a bioma... | glioma | Medium | convergence | {"qa_id":"medium_convergence_06379","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data for this gene in pleural mesothelio... | |
medium_convergence_06380 | MAP2K1 and KSR1 share a common binding partner. Evidence indicates that C-TAK1 constitutively associates with this shared entity, phosphorylating serine 392 to facilitate 14-3-3 binding and cytoplasmic sequestration in unstimulated cells. Which protein is encoded by this shared entity? | MAP/microtubule affinity-regulating kinase 3 | Medium | convergence | {"qa_id":"medium_convergence_06380","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAP2K1 and KSR1 share a common binding partner. Evidence indicates that C-TAK1 constitutively associates with this shared entity, phosphorylating serine 392 ... | |
medium_convergence_06381 | ESR1 and HSP90AA1 share multiple interacting partners. One of these shared partners is characterized by evidence stating that it directly interacts with the ligand binding domain of ER and is recruited to the proximal promoter regions of ER target genes upon gene induction. Which gene interacts with this specific share... | TP53 | Medium | convergence | {"qa_id":"medium_convergence_06381","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HSP90AA1 share multiple interacting partners. One of these shared partners is characterized by evidence stating that it directly interacts with the ... | |
medium_convergence_06382 | PPARA and NCOR1 share multiple binding partners. One such partner is described by the following evidence: 'We show that a WD-40 repeat-containing protein associates with N-CoR through two independent interactions: the N-terminal region and the C-terminal WD-40 repeats interact with the N-CoR RD1 and RD4 region, respect... | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06382","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPARA and NCOR1 share multiple binding partners. One such partner is described by the following evidence: 'We show that a WD-40 repeat-containing protein ass... | |
medium_convergence_06383 | MED19 and MED15 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'By comparing MudPIT data sets obtained from six independent Mediator preparations immunoaffinity purified through their Nut2 (MED10), Med25 (MED9), Intersex, LCMR1, AK007855, or CRSP70 (MED26) subunits, ... | Mediator of RNA polymerase II transcription subunit 29 | Medium | convergence | {"qa_id":"medium_convergence_06383","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MED19 and MED15 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'By comparing MudPIT data sets obtained f... | |
medium_convergence_06384 | HUWE1 and ALDH1B1 share common interaction partners. One such partner is characterized by the following experimental observation: the formation of a conjugate between HUWE1 and FAT10 is diminished in the presence of this partner, whereas the interaction between this partner and HUWE1 is strengthened in the presence of ... | Activating molecule in BECN1-regulated autophagy protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06384","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HUWE1 and ALDH1B1 share common interaction partners. One such partner is characterized by the following experimental observation: the formation of a conjugat... | |
medium_convergence_06386 | CTNNB1 and YWHAG share multiple interacting partners. One such partner is reported to form complexes with beta-catenin and E-cadherin during the formation of cell-cell junctions in MDCK cells. Which disease is associated with this specific partner via a biomarker relationship? | arteriosclerosis disorder | Medium | convergence | {"qa_id":"medium_convergence_06386","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and YWHAG share multiple interacting partners. One such partner is reported to form complexes with beta-catenin and E-cadherin during the formation of... | |
medium_convergence_06387 | CBX3 and CDC16 both interact with a specific protein. Evidence indicates that automethylation of a histone methyltransferase at the ARKT motif creates a binding site for the HP1 class of proteins, and that mutation of the lysine in this motif impairs this binding. Which protein, connected to this entity via an 'encodes... | Histone-lysine N-methyltransferase EHMT2 | Medium | convergence | {"qa_id":"medium_convergence_06387","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and CDC16 both interact with a specific protein. Evidence indicates that automethylation of a histone methyltransferase at the ARKT motif creates a bind... | |
medium_convergence_06389 | PRKN and TRIM33 both interact with a shared protein. Evidence indicates that this shared protein interacts with TIF1gamma in intact cells, as demonstrated by immunoprecipitation studies. Which protein is encoded by this shared entity? | LIM domain-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06389","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and TRIM33 both interact with a shared protein. Evidence indicates that this shared protein interacts with TIF1gamma in intact cells, as demonstrated by... | |
medium_convergence_06390 | E2F1 and GATA1 both interact with a specific shared protein. Evidence indicates that GATA-1 is directly associated with this shared protein, as well as with HDAC4 and HDAC5. Which protein is encoded by this shared entity? | Histone deacetylase 3 | Medium | convergence | {"qa_id":"medium_convergence_06390","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"E2F1 and GATA1 both interact with a specific shared protein. Evidence indicates that GATA-1 is directly associated with this shared protein, as well as with ... | |
medium_convergence_06391 | FKBP8 and PLD1 both interact with a specific shared protein. Evidence indicates that this shared protein interacts directly with FKBP38 and prevents its association with mTOR in a guanosine 5'-triphosphate (GTP)-dependent manner. Which protein is encoded by the gene corresponding to this shared entity? | GTP-binding protein Rheb | Medium | convergence | {"qa_id":"medium_convergence_06391","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FKBP8 and PLD1 both interact with a specific shared protein. Evidence indicates that this shared protein interacts directly with FKBP38 and prevents its asso... | |
medium_convergence_06392 | Rift Valley fever phlebovirus and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log2 fold change of approximately 2.854 and an adjusted p-value of 0.006443. Which protein is encoded by this gene? | C-C motif chemokine 20 | Medium | convergence | {"qa_id":"medium_convergence_06392","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rift Valley fever phlebovirus and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in SAEC cells (study GSE102481) reports a log... | |
medium_convergence_06393 | Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.081 and an adjusted p-value of 0.0237. Which disease is associated with this gene? | oocyte/zygote/embryo maturation arrest 22 | Medium | convergence | {"qa_id":"medium_convergence_06393","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2... | |
medium_convergence_06394 | Both Vaccinia virus and Measles morbillivirus are reported to downregulate a specific shared gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) indicates a log2 fold change of approximately -1.16 and an adjusted p-value of 0.0156. Which cell type is this gene enriched in? | gamma-delta T cell | Medium | convergence | {"qa_id":"medium_convergence_06394","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Measles morbillivirus are reported to downregulate a specific shared gene. Experimental data for this gene in a cervical adenocarcino... | |
medium_convergence_06395 | U2AF2 and PAWR both interact with a shared protein. Evidence indicates that this shared protein interacts with the essential splicing factor U2AF65 and associates with the splicing machinery. Which protein is encoded by this shared entity? | Wilms tumor protein | Medium | convergence | {"qa_id":"medium_convergence_06395","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"U2AF2 and PAWR both interact with a shared protein. Evidence indicates that this shared protein interacts with the essential splicing factor U2AF65 and assoc... | |
medium_convergence_06396 | HDAC1 and ING1 share multiple interaction partners. One such partner is described by evidence stating that Histone deacetylase 1 (HDAC1) interacts with MMTR both in vitro and in vivo, and specifically within the nucleus. Which cell type is this shared partner enriched in? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_06396","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and ING1 share multiple interaction partners. One such partner is described by evidence stating that Histone deacetylase 1 (HDAC1) interacts with MMTR ... | |
medium_convergence_06397 | Both Human alphaherpesvirus 1 and Hepacivirus C are known to downregulate a specific shared gene. In a study using a monocytic leukemia cell line (GSE114966), this gene exhibited a log2 fold change of approximately -1.495 and an adjusted p-value of 0.00526. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_06397","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Hepacivirus C are known to downregulate a specific shared gene. In a study using a monocytic leukemia cell line (GSE114966)... | |
medium_convergence_06398 | MICU2 and MCUR1 are both involved in more than one shared biological process. Evidence concerning one of these shared entities states: 'At low [Ca(2+)], the dominant effect of MICU2 largely shuts down MCU activity.' Which biological process is a parent of that entity (connected via 'is a')? | calcium ion transmembrane transport | Medium | convergence | {"qa_id":"medium_convergence_06398","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MICU2 and MCUR1 are both involved in more than one shared biological process. Evidence concerning one of these shared entities states: 'At low [Ca(2+)], the ... | |
medium_convergence_06399 | Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of -1.711 and an adjusted p-value of 0.01754. Which protein is encoded by this gene? | Ras-related protein Rab-30 | Medium | convergence | {"qa_id":"medium_convergence_06399","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates tha... | |
medium_convergence_06400 | CHD4 and FBXO32 both interact with a common protein partner. Experimental evidence indicates that the purification of a complex involving this shared partner allowed for the identification of CHD4 as an associated protein via tandem mass spectrometric sequencing. Which protein is encoded by this shared partner? | Serine/threonine-protein kinase ATR | Medium | convergence | {"qa_id":"medium_convergence_06400","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and FBXO32 both interact with a common protein partner. Experimental evidence indicates that the purification of a complex involving this shared partner... | |
medium_convergence_06401 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE100576) reports a log2 fold change of approximately 1.698 and an adjusted p-value of 0.03823. Which cellular component is this gene located in? | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_06401","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (stud... | |
medium_convergence_06402 | GNAI3 and GNAQ both interact with a shared protein. Evidence for this protein states: 'Consistent with its activity in in vitro GTPase-activating protein assays, the protein interacts efficiently with endogenous proteins of the Gi and Gq subclasses of Galpha subunits but not with G12alpha or Gsalpha.' Which disease is ... | drug-induced dyskinesia | Medium | convergence | {"qa_id":"medium_convergence_06402","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI3 and GNAQ both interact with a shared protein. Evidence for this protein states: 'Consistent with its activity in in vitro GTPase-activating protein ass... | |
medium_convergence_06403 | SMAD1 and SMAD7 each interact with a shared protein partner. Evidence concerning one such partner states: 'In both yeast two-hybrid and in vitro binding assays, we found that this protein could interact with receptor-activated Smads (R-Smads), including Smad1, Smad2, and Smad3 but not Smad4.' Which protein is encoded b... | E3 ubiquitin-protein ligase SMURF2 | Medium | convergence | {"qa_id":"medium_convergence_06403","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD1 and SMAD7 each interact with a shared protein partner. Evidence concerning one such partner states: 'In both yeast two-hybrid and in vitro binding assa... | |
medium_convergence_06404 | GNA15 and GNAI3 each interact with more than one shared gene. Evidence concerning one shared entity reports that it was shown to interact specifically with the G(alphai-3) subunit in membranes from K562 cells. Which cell type is that entity enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_06404","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNA15 and GNAI3 each interact with more than one shared gene. Evidence concerning one shared entity reports that it was shown to interact specifically with t... | |
medium_convergence_06406 | GH1 and IL2RB each share a binding partner. Evidence concerning one such shared entity reports that a specific suppressor of cytokine signaling protein also interacts with IL-2Rbeta, and this interaction requires the A region (residues 313-382) of IL-2Rbeta. Which protein is connected to that entity through encodes? | Suppressor of cytokine signaling 1 | Medium | convergence | {"qa_id":"medium_convergence_06406","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GH1 and IL2RB each share a binding partner. Evidence concerning one such shared entity reports that a specific suppressor of cytokine signaling protein also ... | |
medium_convergence_06407 | CDKN2A and XRCC6 both interact with a specific protein. Evidence regarding one such shared interaction partner states: 'Through biochemical purification, we identified a specific ubiquitin ligase for ARF and named it [this protein].' Which protein is encoded by this shared interaction partner? | E3 ubiquitin-protein ligase TRIP12 | Medium | convergence | {"qa_id":"medium_convergence_06407","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN2A and XRCC6 both interact with a specific protein. Evidence regarding one such shared interaction partner states: 'Through biochemical purification, we ... | |
medium_convergence_06408 | CEBPB and GSK3B share common interaction partners. One such shared partner is described by the evidence: 'We show for the first time that this protein binds directly to NF-IL6 in vivo and antagonizes its activity.' Which disease is associated with this specific entity via a biomarker relationship? | ovarian cancer | Medium | convergence | {"qa_id":"medium_convergence_06408","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPB and GSK3B share common interaction partners. One such shared partner is described by the evidence: 'We show for the first time that this protein binds ... | |
medium_convergence_06409 | ADRM1 and PSMB2 each share a binding partner with another gene. Evidence concerning one of these shared partners indicates that hRpn13 interacts with a base subunit via its amino-terminus. Which disease is associated with that specific shared partner? | lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06409","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADRM1 and PSMB2 each share a binding partner with another gene. Evidence concerning one of these shared partners indicates that hRpn13 interacts with a base ... | |
medium_convergence_06411 | Oxytocin and Fluconazole share a common drug interaction partner. Clinical data regarding co-prescriptions for Fluconazole indicate that Solifenacin (34.9%), clarithromycin (18.1%), the shared entity (15.1%), and donepezil (10.4%) are frequently co-prescribed. Which disease is the shared entity indicated for? | benign prostatic hyperplasia | Medium | convergence | {"qa_id":"medium_convergence_06411","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Oxytocin and Fluconazole share a common drug interaction partner. Clinical data regarding co-prescriptions for Fluconazole indicate that Solifenacin (34.9%),... | |
medium_convergence_06412 | Zaire ebolavirus and Zika virus both downregulate a specific host gene. Experimental data from a study on retinal pigment epithelium cells (GSE100839) indicates that this gene has a log2 fold change of approximately -1.043 and an adjusted p-value of 0.009696. Which protein is encoded by this gene? | CCAAT/enhancer-binding protein beta | Medium | convergence | {"qa_id":"medium_convergence_06412","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Zika virus both downregulate a specific host gene. Experimental data from a study on retinal pigment epithelium cells (GSE100839) indica... | |
medium_convergence_06414 | FIGNL1 and BRCA1 share a common binding partner. Evidence regarding this shared partner states: 'Here, it is shown that BRCA1 interacts in vitro and in vivo with [the protein encoded by the shared binding partner], which forms a complex with hMre11 and p95/nibrin.' Which protein is encoded by this shared binding partne... | DNA repair protein RAD50 | Medium | convergence | {"qa_id":"medium_convergence_06414","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FIGNL1 and BRCA1 share a common binding partner. Evidence regarding this shared partner states: 'Here, it is shown that BRCA1 interacts in vitro and in vivo ... | |
medium_convergence_06415 | GHR and JAK2 share common binding partners. One such partner is described in an assay where only TC-PTP, a specific protein tyrosine phosphatase, PTP-H1, and SAP-1 interacted with the mature form of the phosphorylated GHR. Which protein is encoded by the gene corresponding to this shared partner? | Tyrosine-protein phosphatase non-receptor type 1 | Medium | convergence | {"qa_id":"medium_convergence_06415","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GHR and JAK2 share common binding partners. One such partner is described in an assay where only TC-PTP, a specific protein tyrosine phosphatase, PTP-H1, and... | |
medium_convergence_06416 | EWSR1 and PUF60 share multiple interacting partners. One such shared partner is supported by evidence stating: 'Here we report that this protein also interacts with EWS in both two-hybrid assays and glutathione S-transferase pull-down experiments.' Which protein is encoded by this shared interacting partner? | Splicing factor 1 | Medium | convergence | {"qa_id":"medium_convergence_06416","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EWSR1 and PUF60 share multiple interacting partners. One such shared partner is supported by evidence stating: 'Here we report that this protein also interac... | |
medium_convergence_06417 | Both Human alphaherpesvirus 3 and Zaire ebolavirus are associated with the downregulation of a specific gene. Experimental data from a melanoma cell line (study GSE136586) indicates that this gene exhibits a log2 fold change of -1.376 and an adjusted p-value of 3.074e-07. Which protein is encoded by this gene? | Potassium channel subfamily K member 6 | Medium | convergence | {"qa_id":"medium_convergence_06417","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zaire ebolavirus are associated with the downregulation of a specific gene. Experimental data from a melanoma cell line (st... | |
medium_convergence_06418 | SMAD3 and PTK2 both interact with a shared protein. Evidence regarding this shared protein indicates that co-immunoprecipitation studies in HEK293 cells demonstrate an interaction between a specific LIM-domain protein and either a CA-mutant or wild-type version of the shared protein. This interaction occurs through the... | basophil | Medium | convergence | {"qa_id":"medium_convergence_06418","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD3 and PTK2 both interact with a shared protein. Evidence regarding this shared protein indicates that co-immunoprecipitation studies in HEK293 cells demo... | |
medium_convergence_06420 | Measles morbillivirus and Cardiovirus A both downregulate a specific gene. Experimental evidence for this gene reports a log2 fold change of -1.128 and an adjusted p-value of 0.03561. Which protein does this gene interact with? | GNPTAB | Medium | convergence | {"qa_id":"medium_convergence_06420","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Cardiovirus A both downregulate a specific gene. Experimental evidence for this gene reports a log2 fold change of -1.128 and an ad... | |
medium_convergence_06421 | CCDC22 and ARNT each interact with more than one shared protein partner. Evidence concerning one such shared entity reports that immunoprecipitation and in vitro binding experiments suggest CK1-dependent phosphorylation of the alpha subunit of hypoxia-inducible factor 1 at Ser247 impairs its association with this partn... | Hypoxia-inducible factor 1-alpha | Medium | convergence | {"qa_id":"medium_convergence_06421","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCDC22 and ARNT each interact with more than one shared protein partner. Evidence concerning one such shared entity reports that immunoprecipitation and in v... | |
medium_convergence_06422 | In a study of non-small cell lung adenocarcinoma cells (GSE147507), both Influenza A virus and Dengue virus were found to upregulate a specific gene. Evidence for this shared target reports a log2 fold change of approximately 1.020 and an adjusted p-value of 0.000226. Which protein is encoded by this gene? | Protein arginine N-methyltransferase 3 | Medium | convergence | {"qa_id":"medium_convergence_06422","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"In a study of non-small cell lung adenocarcinoma cells (GSE147507), both Influenza A virus and Dengue virus were found to upregulate a specific gene. Evidenc... | |
medium_convergence_06423 | LAMTOR1 and ATP6V1F each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'A complex encoded by the MAPKSP1, ROBLD3, and c11orf59 genes, which we term Ragulator, interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation.' Which dise... | Long-Olsen-Distelmaier syndrome | Medium | convergence | {"qa_id":"medium_convergence_06423","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAMTOR1 and ATP6V1F each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'A complex encoded by the MAPKSP1, R... | |
medium_convergence_06424 | DDX6 and DCP1B both interact with a shared protein partner. Evidence regarding one such partner states: 'We present the crystal structure of the DDX6 C-terminal RecA-like domain bound to a highly conserved FDF sequence motif in the decapping activator [Partner].' Which protein is encoded by this [Partner]? | Enhancer of mRNA-decapping protein 3 | Medium | convergence | {"qa_id":"medium_convergence_06424","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDX6 and DCP1B both interact with a shared protein partner. Evidence regarding one such partner states: 'We present the crystal structure of the DDX6 C-termi... | |
medium_convergence_06425 | C1D and NCBP1 each interact with more than one shared gene product. Evidence concerning one shared entity reports that the protein binds the cap-binding complex (CBC), universally present on capped RNAs, while also associating with the nuclear exosome targeting (NEXT) complex, linking to RNA decay. Which gene is connec... | ZCCHC8 | Medium | convergence | {"qa_id":"medium_convergence_06425","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"C1D and NCBP1 each interact with more than one shared gene product. Evidence concerning one shared entity reports that the protein binds the cap-binding comp... | |
medium_convergence_06426 | Enterovirus A and Rhinovirus A both downregulate a specific gene. Experimental data from a study on rhabdomyosarcoma cells (GSE103308) indicates that this gene has a log2 fold change of -1.728 and an adjusted p-value of 0.001797. Which protein is encoded by this gene? | RNA-binding protein 43 | Medium | convergence | {"qa_id":"medium_convergence_06426","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Rhinovirus A both downregulate a specific gene. Experimental data from a study on rhabdomyosarcoma cells (GSE103308) indicates that this ge... | |
medium_convergence_06427 | MICU2 and SMDT1 are both involved in more than one shared biological process. Evidence concerning one of these shared entities states: 'At low [Ca(2+)], the dominant effect of MICU2 largely shuts down MCU activity.' Which biological process is a parent term (is_a) of that specific entity? | calcium ion transmembrane transport | Medium | convergence | {"qa_id":"medium_convergence_06427","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MICU2 and SMDT1 are both involved in more than one shared biological process. Evidence concerning one of these shared entities states: 'At low [Ca(2+)], the ... | |
medium_convergence_06428 | The genes CHRNB1 and CHRNB2 are both involved in multiple shared biological processes. One of these shared processes is linked to evidence stating that Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE; MIM 600513) has been associated with mutations in the genes coding for the alpha-4 (CHRNA4), beta-2 (CHRNB2)... | system process | Medium | convergence | {"qa_id":"medium_convergence_06428","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The genes CHRNB1 and CHRNB2 are both involved in multiple shared biological processes. One of these shared processes is linked to evidence stating that Autos... | |
medium_convergence_06429 | Human polyomavirus 1 and Enterovirus A both upregulate a specific gene. Evidence for this gene in a study (GSE135833) reports a log2 fold change of approximately 1.399 and an adjusted p-value of approximately 0.02003. Which cell type is this gene enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_06429","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Enterovirus A both upregulate a specific gene. Evidence for this gene in a study (GSE135833) reports a log2 fold change of approxima... | |
medium_convergence_06430 | GNG4 and ARRB1 both physically interact with a specific protein. Experimental evidence indicates that beta-arrestin 1 physically interacts with the delta opioid receptor (DOR) in an agonist-enhanced manner, and that truncation of the carboxyl terminus of DOR partially impairs this interaction. Which disease is associat... | common cold | Medium | convergence | {"qa_id":"medium_convergence_06430","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNG4 and ARRB1 both physically interact with a specific protein. Experimental evidence indicates that beta-arrestin 1 physically interacts with the delta opi... | |
medium_convergence_06431 | ESR1 and ESR2 share interaction partners. One such shared partner is ASC-2, which is reported to interact with other nuclear receptors (including retinoic acid receptor, thyroid hormone receptor, estrogen receptor alpha, and glucocorticoid receptor), basal factors TFIIA and TBP, and transcription integrators CBP/p300 a... | Nuclear receptor coactivator 6 | Medium | convergence | {"qa_id":"medium_convergence_06431","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and ESR2 share interaction partners. One such shared partner is ASC-2, which is reported to interact with other nuclear receptors (including retinoic ac... |
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