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medium_convergence_06547 | GRSF1 and MDM2 both interact with a specific shared protein. Evidence indicates that MDM2 directly binds and sequesters this shared protein, preventing its mitochondrial localization and ultimately causing complex I and supercomplex destabilization and inefficiency of oxidative phosphorylation. Which protein is encoded... | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_06547","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRSF1 and MDM2 both interact with a specific shared protein. Evidence indicates that MDM2 directly binds and sequesters this shared protein, preventing its m... | |
medium_convergence_06548 | COMMD1 and ELOC both interact with a specific protein. Evidence regarding this shared interaction partner states: 'Like other SOCS family members, SOCS-6 binds to elongins B and C through its SOCS box, suggesting that it might act as an E3 ubiquitin ligase that targets proteins bound to its SH2 domain for ubiquitinatio... | Suppressor of cytokine signaling 6 | Medium | convergence | {"qa_id":"medium_convergence_06548","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and ELOC both interact with a specific protein. Evidence regarding this shared interaction partner states: 'Like other SOCS family members, SOCS-6 bin... | |
medium_convergence_06549 | The genes ANK2 and KCNQ1 are both involved in multiple shared biological processes. One of these shared processes is linked to the gene KVLQT1 (also known as KCNQ1), which is described in the evidence as a novel cardiac potassium channel gene where mutations cause susceptibility to ventricular tachyarrhythmias and sudd... | cardiac muscle cell action potential involved in contraction | Medium | convergence | {"qa_id":"medium_convergence_06549","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The genes ANK2 and KCNQ1 are both involved in multiple shared biological processes. One of these shared processes is linked to the gene KVLQT1 (also known as... | |
medium_convergence_06550 | Both Human mastadenovirus C and Zika virus have been shown to upregulate the expression of a specific gene. In a study involving lung fibroblast cell lines (GSE120891), this shared target gene exhibited a log2 fold change of 1.721 and an adjusted p-value of 0.03813. Which protein is encoded by this gene? | Homeobox protein TGIF1 | Medium | convergence | {"qa_id":"medium_convergence_06550","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Zika virus have been shown to upregulate the expression of a specific gene. In a study involving lung fibroblast cell lines (... | |
medium_convergence_06551 | GTF3C1 and GTF3C2 each interact with more than one shared partner. Evidence concerning one such shared partner reports: 'These include novel interactions of hTFIIIC63 with hTFIIIC102, with hTFIIIB90, and with hRPC62, in addition to the hTFIIIC102-hTFIIIB90 and hTFIIIB90-hRPC39 interactions that parallel the previously ... | neurodevelopmental disorder with dysmorphic facies, brain anomalies, and seizures | Medium | convergence | {"qa_id":"medium_convergence_06551","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF3C1 and GTF3C2 each interact with more than one shared partner. Evidence concerning one such shared partner reports: 'These include novel interactions of ... | |
medium_convergence_06552 | BRD4 and HDAC1 both interact with a shared protein entity. Experimental evidence indicates that this entity binds directly to the largest subunit, RFC-140, thereby interacting with the entire Replication Factor C (RFC) complex. Which protein is encoded by this shared entity? | Replication factor C subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_06552","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and HDAC1 both interact with a shared protein entity. Experimental evidence indicates that this entity binds directly to the largest subunit, RFC-140, t... | |
medium_convergence_06553 | BABAM1 and ATM each interact with more than one shared protein. Evidence concerning one shared entity reports that ATM forms a stable complex with a histone acetyltransferase through the conserved FATC domain of ATM. Which disease is connected to that entity through a biomarker relationship? | mammary neoplasms, animal | Medium | convergence | {"qa_id":"medium_convergence_06553","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BABAM1 and ATM each interact with more than one shared protein. Evidence concerning one shared entity reports that ATM forms a stable complex with a histone ... | |
medium_convergence_06554 | Both 'regulation of mast cell degranulation' and 'regulation of eosinophil degranulation' are subtypes of a shared biological process. Evidence for this shared process states: 'Any process that modulates the frequency, rate, or extent of mast cell degranulation.' Which biological process is directly regulated by this s... | leukocyte degranulation | Medium | convergence | {"qa_id":"medium_convergence_06554","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both 'regulation of mast cell degranulation' and 'regulation of eosinophil degranulation' are subtypes of a shared biological process. Evidence for this shar... | |
medium_convergence_06555 | FYN and HNRNPK both interact with a specific shared protein. Evidence regarding this shared protein describes mutants of a receptor-type tyrosine-protein phosphatase (containing a Cys to Ser mutation in the catalytic center of PTPase D1) that bind to tyrosine-phosphorylated Lck and Fyn, noting that the phosphatase doma... | Receptor-type tyrosine-protein phosphatase F | Medium | convergence | {"qa_id":"medium_convergence_06555","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FYN and HNRNPK both interact with a specific shared protein. Evidence regarding this shared protein describes mutants of a receptor-type tyrosine-protein pho... | |
medium_convergence_06556 | BRD4 and HSPA4 both interact with a specific shared protein. Evidence indicates that HSP70 binds to this protein, and in vitro, the conversion of this protein's chains into monomers stimulates HSP70 ATPase activity. Which protein is encoded by the gene corresponding to this shared entity? | Ubiquitin-like protein NEDD8 | Medium | convergence | {"qa_id":"medium_convergence_06556","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and HSPA4 both interact with a specific shared protein. Evidence indicates that HSP70 binds to this protein, and in vitro, the conversion of this protei... | |
medium_convergence_06557 | EGLN1 and ELOB both interact with a specific protein that functions as a tumor suppressor. Evidence indicates that the LIM domain-containing protein (LIMD1) acts as a molecular scaffold, simultaneously binding prolyl hydroxylase domain proteins (PHDs) and this specific protein, thereby assembling a PHD-LIMD1-protein co... | von Hippel-Lindau disease tumor suppressor | Medium | convergence | {"qa_id":"medium_convergence_06557","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGLN1 and ELOB both interact with a specific protein that functions as a tumor suppressor. Evidence indicates that the LIM domain-containing protein (LIMD1) ... | |
medium_convergence_06558 | SMAD3 and SMAD4 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports that TFEB and Max are associated with this partner, as well as with SMAD3 and SMAD4, in the absence of DNA and at the PE2.1 element of the PAI-1 promoter. Which protein is connected to that share... | Transcription factor E3 | Medium | convergence | {"qa_id":"medium_convergence_06558","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD3 and SMAD4 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports that TFEB and Max are associated... | |
medium_convergence_06559 | Mefloquine and Cyproheptadine share a common drug interaction partner. Clinical evidence regarding this shared partner states: 'The symptoms and signs were resolved within 3 days following hydration, sedation, and cyproheptadine.' Which disease is this shared drug indicated for? | bipolar I disorder | Medium | convergence | {"qa_id":"medium_convergence_06559","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Mefloquine and Cyproheptadine share a common drug interaction partner. Clinical evidence regarding this shared partner states: 'The symptoms and signs were r... | |
medium_convergence_06560 | HCN4 and RYR2 are both involved in more than one shared biological process. Evidence concerning one of these shared processes states: 'In myocardial cells, the RYR2 protein, activated by Ca(2+), induces the release of calcium from the sarcoplasmic reticulum into the cytosol.' Which biological process is connected to th... | cardiac muscle contraction | Medium | convergence | {"qa_id":"medium_convergence_06560","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HCN4 and RYR2 are both involved in more than one shared biological process. Evidence concerning one of these shared processes states: 'In myocardial cells, t... | |
medium_convergence_06561 | Both Human alphaherpesvirus 3 and Rhinovirus A are associated with the upregulation of a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately 1.27 and an adjusted p-value of 1.406e-05. Which protein is encoded by this gene? | Tumor necrosis factor receptor superfamily member 9 | Medium | convergence | {"qa_id":"medium_convergence_06561","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Rhinovirus A are associated with the upregulation of a specific gene. Experimental data for this gene in a melanoma cell li... | |
medium_convergence_06562 | Hepacivirus C and Human mastadenovirus C both downregulate a specific gene. Evidence for this shared target reports a log2 fold change of -1.163 and an adjusted p-value of 2.606e-14. Which protein is encoded by this gene? | TLC domain-containing protein 5 | Medium | convergence | {"qa_id":"medium_convergence_06562","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Human mastadenovirus C both downregulate a specific gene. Evidence for this shared target reports a log2 fold change of -1.163 and an adjus... | |
medium_convergence_06563 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus upregulate a specific host gene. Experimental data from a study on lung fibroblast cell lines (GSE120891) indicates that this shared target exhibits a log2 fold change of approximately 2.01 and an adjusted p-value of 0.038. Which biol... | regulation of RNA splicing | Medium | convergence | {"qa_id":"medium_convergence_06563","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus upregulate a specific host gene. Experimental data from a study on lung... | |
medium_convergence_06564 | PRMT5 and ESR1 share multiple interacting partners. One such shared partner exhibits an estrogen-responsive interaction with ERalpha. Which protein is encoded by this specific shared partner? | Paired amphipathic helix protein Sin3a | Medium | convergence | {"qa_id":"medium_convergence_06564","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRMT5 and ESR1 share multiple interacting partners. One such shared partner exhibits an estrogen-responsive interaction with ERalpha. Which protein is encode... | |
medium_convergence_06565 | UBE2D2 and UBE2D3 both interact with a shared protein partner. Evidence indicates that this partner's RING domain, in complex with UBE2D2, functions as an E3 ligase for the ubiquitylation of the p53 transactivation domain (p53-TAD), and structural studies have reported the purification and crystallization of this RING ... | cervical cancer | Medium | convergence | {"qa_id":"medium_convergence_06565","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBE2D2 and UBE2D3 both interact with a shared protein partner. Evidence indicates that this partner's RING domain, in complex with UBE2D2, functions as an E3... | |
medium_convergence_06566 | EP300 and RARA share multiple interacting partners. One such shared partner is described in a study reporting that topoisomerase II beta (TopoIIbeta) associates with and negatively modulates the transcriptional activity of this entity. Which protein is encoded by this shared interacting partner? | DNA topoisomerase 2-beta | Medium | convergence | {"qa_id":"medium_convergence_06566","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and RARA share multiple interacting partners. One such shared partner is described in a study reporting that topoisomerase II beta (TopoIIbeta) associa... | |
medium_convergence_06567 | CHD3 and KDM1A both interact with a shared protein. Evidence indicates that this shared protein is associated with histone demethylase complexes containing lysine-specific demethylase 1 (LSD1), RE1 silencing transcription factor corepressor (CoREST), histone deacetylase 1 (HDAC1), and histone deacetylase 2 in erythrole... | T-cell acute lymphocytic leukemia protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06567","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and KDM1A both interact with a shared protein. Evidence indicates that this shared protein is associated with histone demethylase complexes containing l... | |
medium_convergence_06568 | YWHAB and CUL3 both interact with a shared protein. Evidence regarding this shared protein states: 'With the exception of KCTD16, all proteins bound to Cul3 and were observed to reassemble in solution as 5 : 5 heterodecamers.' Which protein is encoded by this shared entity? | SH3KBP1-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06568","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAB and CUL3 both interact with a shared protein. Evidence regarding this shared protein states: 'With the exception of KCTD16, all proteins bound to Cul3 ... | |
medium_convergence_06570 | KMT2A and PML share multiple interacting partners. One such shared partner is known to interact and co-localize with both MOZ and MLL in immature hematopoietic cells. Which gene does this specific shared partner interact with? | YBX3 | Medium | convergence | {"qa_id":"medium_convergence_06570","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KMT2A and PML share multiple interacting partners. One such shared partner is known to interact and co-localize with both MOZ and MLL in immature hematopoiet... | |
medium_convergence_06571 | XRCC6 and XPO1 each interact with more than one shared gene product. Evidence concerning one shared entity reports that it binds directly to Crm1, and the resulting complex possesses an enhanced affinity for both Ran:GTP and cargo. Which protein is encoded by that entity? | Ran-binding protein 3 | Medium | convergence | {"qa_id":"medium_convergence_06571","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"XRCC6 and XPO1 each interact with more than one shared gene product. Evidence concerning one shared entity reports that it binds directly to Crm1, and the re... | |
medium_convergence_06572 | MICU2 and SMDT1 are both associated with a specific biological process. Evidence indicates that MICU1 and the entity defining this process are the main regulators of the mitochondrial Ca(2+)-uniporter (MCU). Which biological process is this? | intracellular calcium ion homeostasis | Medium | convergence | {"qa_id":"medium_convergence_06572","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MICU2 and SMDT1 are both associated with a specific biological process. Evidence indicates that MICU1 and the entity defining this process are the main regul... | |
medium_convergence_06573 | RACK1 and MAPT share interaction partners. One such shared partner is implicated in a study where pull-down and immunoprecipitation assays revealed that type II PKA interacted with IFNAR2 via RACK1, an interaction inhibited by luteolin. Which protein encodes this shared interaction partner? | cAMP-dependent protein kinase type II-alpha regulatory subunit | Medium | convergence | {"qa_id":"medium_convergence_06573","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RACK1 and MAPT share interaction partners. One such shared partner is implicated in a study where pull-down and immunoprecipitation assays revealed that type... | |
medium_convergence_06574 | ERLIN2 and ERLEC1 both interact with a common protein partner. Evidence indicates that OS-9 and XTP3-B/Erlectin are ER-resident glycoproteins that bind to ERAD substrates and, through this specific adaptor protein, to the ER-membrane-embedded ubiquitin ligase Hrd1. Which protein is encoded by the gene corresponding to ... | Protein sel-1 homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_06574","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERLIN2 and ERLEC1 both interact with a common protein partner. Evidence indicates that OS-9 and XTP3-B/Erlectin are ER-resident glycoproteins that bind to ER... | |
medium_convergence_06575 | Human betaherpesvirus 5 and Human respirovirus 3 both downregulate a specific gene. Experimental data for this gene shows a log2 fold change of -1.342 and an adjusted p-value of 2.074e-10. In which cell type is this gene enriched? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_06575","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human respirovirus 3 both downregulate a specific gene. Experimental data for this gene shows a log2 fold change of -1.342 and an... | |
medium_convergence_06576 | CHAF1A and EP300 share a common interaction partner. Evidence regarding this partner states: 'In this study, we demonstrate that MBD1 partners with the p150 subunit of chromatin assembly factor 1 (CAF-1), forming a multiprotein complex that also contains [the shared interaction partner].' Which cell type is enriched fo... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_06576","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHAF1A and EP300 share a common interaction partner. Evidence regarding this partner states: 'In this study, we demonstrate that MBD1 partners with the p150 ... | |
medium_convergence_06577 | West Nile virus and Human gammaherpesvirus 8 both upregulate a specific gene. In a study of monocyte-derived dendritic cells (GSE136342), the upregulation of this gene by West Nile virus was associated with a log2 fold change of approximately 1.045 and an adjusted p-value of 0.004282. Which protein is encoded by this g... | Interferon-induced protein with tetratricopeptide repeats 5 | Medium | convergence | {"qa_id":"medium_convergence_06577","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"West Nile virus and Human gammaherpesvirus 8 both upregulate a specific gene. In a study of monocyte-derived dendritic cells (GSE136342), the upregulation of... | |
medium_convergence_06578 | H2AFZ and MYC share multiple interacting partners. One such partner is characterized by evidence stating that its upregulation increases binding with c-Myc and activates c-Myc, thereby inducing CCND1/CDK4 expression and promoting glioma cell temozolomide resistance and proliferation. Which cellular component is this sp... | membrane | Medium | convergence | {"qa_id":"medium_convergence_06578","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H2AFZ and MYC share multiple interacting partners. One such partner is characterized by evidence stating that its upregulation increases binding with c-Myc a... | |
medium_convergence_06579 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from a study on lung fibroblast cell lines (GSE120891) indicates that this gene exhibits a log2 fold change of approximately 2.53 and an adjusted p-value of approximate... | prostaglandin E receptor activity | Medium | convergence | {"qa_id":"medium_convergence_06579","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data from ... | |
medium_convergence_06580 | Both IKBKB and MAVS interact with a common protein. Evidence regarding this shared partner states: 'Upon the recognition of viral RNA, the Lys-172 residue of this protein undergoes ubiquitination induced by tripartite motif protein 25 (TRIM25), an essential protein for antiviral signal transduction.' Which protein is e... | Antiviral innate immune response receptor RIG-I | Medium | convergence | {"qa_id":"medium_convergence_06580","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IKBKB and MAVS interact with a common protein. Evidence regarding this shared partner states: 'Upon the recognition of viral RNA, the Lys-172 residue of... | |
medium_convergence_06581 | Rhinovirus A and Zika virus both upregulate a specific gene. Evidence for this gene in a particular study (GSE106475) reports a log2 fold change of approximately 1.04 and an adjusted p-value of approximately 0.024. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_06581","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Evidence for this gene in a particular study (GSE106475) reports a log2 fold change of approxima... | |
medium_convergence_06583 | KCNE5 and SCN5A are both associated with multiple shared biological processes. One of these shared processes involves an entity that has been shown to modify the transient outward current (I(to)), a current that plays a key role in determining the repolarization process in the myocardium. Which biological process is th... | regulation of cardiac muscle cell membrane repolarization | Medium | convergence | {"qa_id":"medium_convergence_06583","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNE5 and SCN5A are both associated with multiple shared biological processes. One of these shared processes involves an entity that has been shown to modify... | |
medium_convergence_06584 | BRD8 and DMAP1 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports that Yeast two-hybrid screening and subsequent immunoprecipitation analysis identified bromodomain containing 8 (BRD8) as an interacting protein for this entity. Which protein is encoded by that s... | MRG/MORF4L-binding protein | Medium | convergence | {"qa_id":"medium_convergence_06584","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD8 and DMAP1 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports that Yeast two-hybrid screening a... | |
medium_convergence_06585 | RPS27A and RBX1 both interact with a specific protein. Evidence indicates that this protein specifically interacts with endogenous Cul2 in mammalian cells, whereas SOCS-box proteins associate with Cul5-Rbx2. Which protein is encoded by the gene corresponding to this interacting entity? | von Hippel-Lindau disease tumor suppressor | Medium | convergence | {"qa_id":"medium_convergence_06585","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPS27A and RBX1 both interact with a specific protein. Evidence indicates that this protein specifically interacts with endogenous Cul2 in mammalian cells, w... | |
medium_convergence_06586 | ACTN4 and ACTN2 each interact with more than one shared gene product. Evidence concerning one shared entity states: 'We expressed both alpha-actinin-2 and -3 in vitro and were able to detect their interaction by both blot overlay and co-immunoprecipitation methods.' Which protein is encoded by that shared entity? | Alpha-actinin-3 | Medium | convergence | {"qa_id":"medium_convergence_06586","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTN4 and ACTN2 each interact with more than one shared gene product. Evidence concerning one shared entity states: 'We expressed both alpha-actinin-2 and -3... | |
medium_convergence_06587 | HJURP and CENPT both interact with a shared protein. Evidence indicates that this shared protein is recruited to centromeres through a direct interaction between its centromere targeting domain and the Mis18α-β C-terminal coiled-coil domains. Which protein is encoded by the gene corresponding to this shared entity? | Protein Mis18-alpha | Medium | convergence | {"qa_id":"medium_convergence_06587","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HJURP and CENPT both interact with a shared protein. Evidence indicates that this shared protein is recruited to centromeres through a direct interaction bet... | |
medium_convergence_06588 | Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.92 and an adjusted p-value of 0.03048. Which prot... | Zinc finger protein 697 | Medium | convergence | {"qa_id":"medium_convergence_06588","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental d... | |
medium_convergence_06589 | ARPC3 and AP2A2 both interact with a shared protein entity. Evidence indicates that a site in the ankle domain of the clathrin triskelion leg binds a common site on the appendages of tetrameric [AP1 and AP2] and monomeric (GGA1) adaptors. Which protein is encoded by the gene corresponding to this shared entity? | Clathrin heavy chain 1 | Medium | convergence | {"qa_id":"medium_convergence_06589","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC3 and AP2A2 both interact with a shared protein entity. Evidence indicates that a site in the ankle domain of the clathrin triskelion leg binds a common ... | |
medium_convergence_06590 | RCAN1 and JUN both interact with a shared protein entity. Evidence indicates that this entity is calcineurin A, the catalytic subunit of the Ca(2+)/calmodulin-dependent protein phosphatase PP2B, which interacts physically and functionally with DSCR1. Which cell type is this entity enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06590","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RCAN1 and JUN both interact with a shared protein entity. Evidence indicates that this entity is calcineurin A, the catalytic subunit of the Ca(2+)/calmoduli... | |
medium_convergence_06591 | TUBA1B and U2AF2 share multiple interacting partners. One such shared partner is implicated in a study where microtubule sedimentation and cryo-electron microscopy with 3D reconstruction revealed that the basic N-terminal domain of EML4 mediated its binding to the acidic C-terminal tails of α- and β-tubulin on the micr... | multiple benign circumferential skin creases on limbs 1 | Medium | convergence | {"qa_id":"medium_convergence_06591","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TUBA1B and U2AF2 share multiple interacting partners. One such shared partner is implicated in a study where microtubule sedimentation and cryo-electron micr... | |
medium_convergence_06592 | CLTA and CLTC each interact with more than one shared protein. Evidence concerning one of these shared proteins states: 'The interaction with clathrin is direct and not mediated by epsin-bound AP-2.' Which protein is encoded by the gene corresponding to that shared entity? | Epsin-1 | Medium | convergence | {"qa_id":"medium_convergence_06592","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLTA and CLTC each interact with more than one shared protein. Evidence concerning one of these shared proteins states: 'The interaction with clathrin is dir... | |
medium_convergence_06593 | DPY30 and CBFB both interact with a shared protein partner. Evidence regarding this partner states: 'We report the 2.6 A resolution crystal structure of the complex between the [RUNX1 family transcription factor] Runt domain and CBFbeta, which represents a paradigm for the mode of interaction of this highly conserved f... | basophil | Medium | convergence | {"qa_id":"medium_convergence_06593","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DPY30 and CBFB both interact with a shared protein partner. Evidence regarding this partner states: 'We report the 2.6 A resolution crystal structure of the ... | |
medium_convergence_06595 | CBX1 and MYC share multiple interacting partners. One such shared partner directly interacts with MYC and co-occupies a distal regulatory element of SOX2 to activate SOX2 expression, a mechanism likely involved in neuroectoderm differentiation. Which protein is encoded by this shared partner? | Polycomb group RING finger protein 6 | Medium | convergence | {"qa_id":"medium_convergence_06595","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX1 and MYC share multiple interacting partners. One such shared partner directly interacts with MYC and co-occupies a distal regulatory element of SOX2 to ... | |
medium_convergence_06596 | Both Orthohepevirus A and Enterovirus A are associated with the upregulation of a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) reports a log2 fold change of approximately 1.146 and an adjusted p-value of 0.02809. Which protein is encoded by this gene? | Dynein axonemal heavy chain 14 | Medium | convergence | {"qa_id":"medium_convergence_06596","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Enterovirus A are associated with the upregulation of a specific gene. Experimental data for this gene in hepatocytes (from study G... | |
medium_convergence_06598 | GIGYF2 and GIGYF1 both interact with a common protein partner. Evidence regarding one such partner states: 'Similar to TTP, this protein harbors three proline-rich motifs that bind the GYF domain of GIGYF1.' Which gene interacts with this specific partner? | EIF4E2 | Medium | convergence | {"qa_id":"medium_convergence_06598","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GIGYF2 and GIGYF1 both interact with a common protein partner. Evidence regarding one such partner states: 'Similar to TTP, this protein harbors three prolin... | |
medium_convergence_06600 | CHAF1A and EHMT2 both interact with a shared protein. Evidence regarding this shared protein indicates that automethylation of G9a at the ARKT motif creates a binding site for the HP1 class of proteins, and that mutation of the lysine in this motif impairs this binding. Which protein is encoded by the gene correspondin... | Chromobox protein homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_06600","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHAF1A and EHMT2 both interact with a shared protein. Evidence regarding this shared protein indicates that automethylation of G9a at the ARKT motif creates ... | |
medium_convergence_06602 | EIF3C and EIF3I each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that it interacts directly with eIF3g via glutathione S-transferase pull-down assays. Which protein is connected to that shared partner through the 'encodes' relationship? | Eukaryotic translation initiation factor 3 subunit K | Medium | convergence | {"qa_id":"medium_convergence_06602","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3C and EIF3I each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that it interacts directly ... | |
medium_convergence_06603 | Both Dengue virus and Enterovirus A are known to upregulate the expression of a specific shared gene. Experimental data for this gene, derived from a hepatoma cell line study (GSE110512), reports a log2 fold change of approximately 1.43 and an adjusted p-value of approximately 0.028. In which cellular component is this... | cytosol | Medium | convergence | {"qa_id":"medium_convergence_06603","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Dengue virus and Enterovirus A are known to upregulate the expression of a specific shared gene. Experimental data for this gene, derived from a hepatom... | |
medium_convergence_06604 | Both Human immunodeficiency virus 1 and Dengue virus are reported to upregulate a specific gene. Experimental data for this gene in macrophages (from study GSE108897) indicates a log2 fold change of approximately 2.26 and an adjusted p-value of 3.15e-05. Which protein is encoded by this gene? | Small RNA 2'-O-methyltransferase | Medium | convergence | {"qa_id":"medium_convergence_06604","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are reported to upregulate a specific gene. Experimental data for this gene in macrophages (from study G... | |
medium_convergence_06605 | FYN and LYN each interact with more than one shared gene. Evidence concerning one shared entity reports: 'Furthermore, in vitro and in vivo binding studies indicate that a protein encoded by the shared gene is capable of binding directly to this entity, an interaction mediated by this entity's SH3 domain.' Which diseas... | pneumonia | Medium | convergence | {"qa_id":"medium_convergence_06605","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FYN and LYN each interact with more than one shared gene. Evidence concerning one shared entity reports: 'Furthermore, in vitro and in vivo binding studies i... | |
medium_convergence_06606 | FOS and FOSL1 both interact with a specific transcription factor. Evidence indicates that this factor forms dimers with diverse Jun proteins and is stably associated in vivo with ERK-related proteins. Which cell type is this transcription factor enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06606","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FOS and FOSL1 both interact with a specific transcription factor. Evidence indicates that this factor forms dimers with diverse Jun proteins and is stably as... | |
medium_convergence_06607 | RCAN1 and GSK3A both interact with a shared protein entity. Evidence indicates that this entity is calcineurin A, the catalytic subunit of the Ca(2+)/calmodulin-dependent protein phosphatase PP2B, which interacts physically and functionally with DSCR1. Which cell type is this entity enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06607","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RCAN1 and GSK3A both interact with a shared protein entity. Evidence indicates that this entity is calcineurin A, the catalytic subunit of the Ca(2+)/calmodu... | |
medium_convergence_06608 | IFIH1 and IKBKE each interact with more than one shared protein. Evidence concerning one shared entity reports that this protein contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. Which disease is connect... | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06608","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IFIH1 and IKBKE each interact with more than one shared protein. Evidence concerning one shared entity reports that this protein contained an N-terminal CARD... | |
medium_convergence_06609 | EGFR and UBA1 share a common interacting partner. Evidence indicates that this shared partner competes with c-Cbl to bind the Y1045 residue of EGFR, thereby inhibiting the polyubiquitination and degradation of EGFR. Which protein is encoded by the gene corresponding to this shared interacting partner? | Ubiquitin-conjugating enzyme E2 R1 | Medium | convergence | {"qa_id":"medium_convergence_06609","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and UBA1 share a common interacting partner. Evidence indicates that this shared partner competes with c-Cbl to bind the Y1045 residue of EGFR, thereby ... | |
medium_convergence_06610 | Both Human polyomavirus 1 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) show a log2 fold change of approximately -1.256 and an adjusted p-value of 0.04692. What is the name of the protei... | Glioma pathogenesis-related protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06610","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human polyomavirus 1 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. Experimental data for this ... | |
medium_convergence_06611 | E2F1 and MYCN share common interaction partners. One such shared partner is known to interact specifically with the E2F-1 transactivation domain. Which protein is encoded by this shared partner? | Transformation/transcription domain-associated protein | Medium | convergence | {"qa_id":"medium_convergence_06611","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"E2F1 and MYCN share common interaction partners. One such shared partner is known to interact specifically with the E2F-1 transactivation domain. Which prote... | |
medium_convergence_06612 | GFRA1 and INSR both interact with a shared protein. Evidence regarding this shared protein states: 'During a yeast tri-hybrid assay, phosphorylation of Ser(307) by JNK1 disrupted the interaction between the catalytic domain of the insulin receptor and the PTB domain of IRS-1.' Which protein is encoded by the gene corre... | Insulin receptor substrate 1 | Medium | convergence | {"qa_id":"medium_convergence_06612","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GFRA1 and INSR both interact with a shared protein. Evidence regarding this shared protein states: 'During a yeast tri-hybrid assay, phosphorylation of Ser(3... | |
medium_convergence_06613 | FGF8 and FGF23 both interact with a common receptor. Evidence indicates that the binding of FGF23 to this receptor's splice variant (specifically the 'c' isoform) is stronger in osteoarthritis chondrocytes compared with normal cells. Which protein is encoded by the gene corresponding to this receptor? | Fibroblast growth factor receptor 1 | Medium | convergence | {"qa_id":"medium_convergence_06613","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF8 and FGF23 both interact with a common receptor. Evidence indicates that the binding of FGF23 to this receptor's splice variant (specifically the 'c' iso... | |
medium_convergence_06614 | Zaire ebolavirus and Human gammaherpesvirus 8 both downregulate a specific gene. In a study of retinal pigment epithelium cells (GSE100839), this gene exhibited a log2 fold change of -1.032 and an adjusted p-value of 0.004466. Which protein is encoded by this gene? | Ceramide glucosyltransferase | Medium | convergence | {"qa_id":"medium_convergence_06614","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Human gammaherpesvirus 8 both downregulate a specific gene. In a study of retinal pigment epithelium cells (GSE100839), this gene exhibi... | |
medium_convergence_06615 | Both the androgen receptor (AR) and serine/threonine kinase 4 (STK4) share a common interacting partner. Experimental evidence involving mammalian two-hybrid and glutathione S-transferase pull-down assays indicates that a specific domain within SV (amino acids 594-1268) interacts with the N-terminus and the DNA-binding... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06615","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the androgen receptor (AR) and serine/threonine kinase 4 (STK4) share a common interacting partner. Experimental evidence involving mammalian two-hybrid... | |
medium_convergence_06616 | DNMT3B and BCL7B share a common interaction partner. Experimental evidence indicates that this shared partner interacts with HDAC1, HP1 proteins, Suv39h1, and the ATP-dependent chromatin remodeling enzyme hSNF2H, as demonstrated by immunoprecipitation and GST pull-down assays. Which protein is encoded by this shared in... | Histone deacetylase 2 | Medium | convergence | {"qa_id":"medium_convergence_06616","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNMT3B and BCL7B share a common interaction partner. Experimental evidence indicates that this shared partner interacts with HDAC1, HP1 proteins, Suv39h1, an... | |
medium_convergence_06617 | NEDD4 and YWHAE both interact with a shared protein. Evidence indicates that the PY (Pro-Tyr) motif of this shared protein binds to the WW (Trp-Trp) domains of NEDD4. Which protein is encoded by the gene corresponding to this shared entity? | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 | Medium | convergence | {"qa_id":"medium_convergence_06617","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4 and YWHAE both interact with a shared protein. Evidence indicates that the PY (Pro-Tyr) motif of this shared protein binds to the WW (Trp-Trp) domains ... | |
medium_convergence_06618 | BRD4 and XRCC6 both interact with a shared protein. Experimental evidence indicates that this shared protein binds directly to the largest subunit of the Replication Factor C complex, RFC-140, thereby interacting with the entire RFC complex. Which protein is encoded by the gene corresponding to this shared entity? | Replication factor C subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_06618","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and XRCC6 both interact with a shared protein. Experimental evidence indicates that this shared protein binds directly to the largest subunit of the Rep... | |
medium_convergence_06620 | Both 'positive regulation of T-helper 1 cell differentiation' and 'positive regulation of T-helper 17 cell differentiation' are subtypes of a shared biological process. Evidence regarding one of these shared processes states: 'Any process that activates or increases the frequency, rate or extent of T-helper 1 cell diff... | T-helper cell differentiation | Medium | convergence | {"qa_id":"medium_convergence_06620","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both 'positive regulation of T-helper 1 cell differentiation' and 'positive regulation of T-helper 17 cell differentiation' are subtypes of a shared biologic... | |
medium_convergence_06621 | ERBB3 and PIK3R1 share a common interacting partner. Evidence regarding this shared partner states: 'Here we demonstrate that a protein tyrosine phosphatase associates with both the tyrosine-phosphorylated platelet-derived growth factor (PDGF) receptor and the p85 subunit of phosphatidylinositol 3-kinase in MCF-7 and T... | Tyrosine-protein phosphatase non-receptor type 6 | Medium | convergence | {"qa_id":"medium_convergence_06621","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB3 and PIK3R1 share a common interacting partner. Evidence regarding this shared partner states: 'Here we demonstrate that a protein tyrosine phosphatase ... | |
medium_convergence_06623 | CETN2 and DDB1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Nonetheless, the counteracting effect of this entity on X stabilization requires the interaction between this entity and DDB1.' Which cell type is this entity enriched in? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_06623","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CETN2 and DDB1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Nonetheless, the counteracting effect of this... | |
medium_convergence_06624 | Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus both upregulate a specific gene. Evidence for this shared target in non-small cell lung adenocarcinoma cells (study GSE147507) reports a log2 fold change of 1.223 and an adjusted p-value of 0.04216. Which protein is encoded by this gene? | Interferon-induced transmembrane protein 2 | Medium | convergence | {"qa_id":"medium_convergence_06624","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus both upregulate a specific gene. Evidence for this shared target in non-small ... | |
medium_convergence_06625 | Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Evidence for this shared target in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of -1.529 and an adjusted p-value of 0.002615. Which protein is encoded by this gene? | Extracellular sulfatase Sulf-2 | Medium | convergence | {"qa_id":"medium_convergence_06625","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Evidence for this shared target in a monocytic leukemia cell line (study GSE114... | |
medium_convergence_06626 | BCL2L11 and BAX share a common interaction partner. Evidence from a yeast two-hybrid assay indicates that the protein BOD interacts with diverse antiapoptotic Bcl-2 proteins (including Mcl-1, Bcl-2, Bcl-xL, Bcl-w, Bfl-1, and EBV BHRF-1) but does not interact with proapoptotic Bcl-2 proteins such as BAD, Bak, Bok, and t... | Bcl-2-related protein A1 | Medium | convergence | {"qa_id":"medium_convergence_06626","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BCL2L11 and BAX share a common interaction partner. Evidence from a yeast two-hybrid assay indicates that the protein BOD interacts with diverse antiapoptoti... | |
medium_convergence_06628 | CREBBP and MITF both interact with a specific protein. Evidence indicates that this protein interacts with the general coactivators p300/CBP, representing the first evidence that a PIAS protein can associate with p300/CBP. Which protein is encoded by the gene corresponding to this interacting entity? | E3 SUMO-protein ligase PIAS3 | Medium | convergence | {"qa_id":"medium_convergence_06628","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and MITF both interact with a specific protein. Evidence indicates that this protein interacts with the general coactivators p300/CBP, representing th... | |
medium_convergence_06629 | ITGA3 and ITGB3 both interact with a shared protein target. Evidence indicates that the alpha v beta 3 integrin acts as a receptor for thrombospondin on endothelial and smooth muscle cells. Which gene encodes this thrombospondin protein? | Thrombospondin-1 | Medium | convergence | {"qa_id":"medium_convergence_06629","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ITGA3 and ITGB3 both interact with a shared protein target. Evidence indicates that the alpha v beta 3 integrin acts as a receptor for thrombospondin on endo... | |
medium_convergence_06630 | MAP2K1 and RAF1 share a common binding partner. Evidence regarding this shared entity states: 'The X-ray crystal structure of the complex between the Ras-related protein in the GTP-analogue (GppNHp) form and the Ras-binding domain (RBD) of the Ras effector molecule c-Raf1, a Ser/Thr-specific protein kinase, has been so... | Ras-related protein Rap-1A | Medium | convergence | {"qa_id":"medium_convergence_06630","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAP2K1 and RAF1 share a common binding partner. Evidence regarding this shared entity states: 'The X-ray crystal structure of the complex between the Ras-rel... | |
medium_convergence_06631 | Both ATR and BARD1 interact with a common protein partner. Evidence indicates that this shared partner physically associates with the ATR protein and is phosphorylated by ATR on two specific residues in its N-terminal domain: Thr-99 and Thr-122. Which cell type is this shared protein partner enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_06631","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ATR and BARD1 interact with a common protein partner. Evidence indicates that this shared partner physically associates with the ATR protein and is phos... | |
medium_convergence_06632 | KCNQ1 and SCN5A are both involved in multiple shared biological processes. One shared process is linked to evidence stating: 'Thus, the S140G mutation is likely to initiate and maintain AF by reducing action potential duration and effective refractory period in atrial myocytes.' Which biological process is this shared ... | regulation of cardiac muscle cell membrane repolarization | Medium | convergence | {"qa_id":"medium_convergence_06632","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNQ1 and SCN5A are both involved in multiple shared biological processes. One shared process is linked to evidence stating: 'Thus, the S140G mutation is lik... | |
medium_convergence_06633 | SMAD3 and SMAD7 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'A yeast two-hybrid screen of a human placental cDNA expression library using full-length mouse Smad7 as bait identified Yes-Associated Protein as a novel Smad7-interacting protein.' Which protei... | Transcriptional coactivator YAP1 | Medium | convergence | {"qa_id":"medium_convergence_06633","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD3 and SMAD7 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'A yeast two-hybrid screen of a ... | |
medium_convergence_06634 | TANK and TICAM1 both interact with a common protein partner. Evidence regarding this shared partner states: 'The crystal structure of a region of TANK bound to [the shared partner] has been determined and compared to a similar CD40/[the shared partner] complex.' Which protein is encoded by this shared partner? | TNF receptor-associated factor 3 | Medium | convergence | {"qa_id":"medium_convergence_06634","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TANK and TICAM1 both interact with a common protein partner. Evidence regarding this shared partner states: 'The crystal structure of a region of TANK bound ... | |
medium_convergence_06635 | Human alphaherpesvirus 1 and Primate bocaparvovirus 1 are both reported to downregulate a specific host gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of approximately -1.261 and an adjusted p-value of 0.003173. What molecular function is enabled by th... | extracellular matrix protein binding | Medium | convergence | {"qa_id":"medium_convergence_06635","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Primate bocaparvovirus 1 are both reported to downregulate a specific host gene. Experimental data for this gene in a monocytic ... | |
medium_convergence_06637 | Both Cardiovirus A and Zika virus are known to upregulate a specific gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE122967) indicates that this shared target exhibits a log2 fold change of approximately 1.665 and an adjusted p-value of 0.01156. Which cellular component is this gene locat... | extracellular space | Medium | convergence | {"qa_id":"medium_convergence_06637","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Cardiovirus A and Zika virus are known to upregulate a specific gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE122967) i... | |
medium_convergence_06639 | TNFSF10 and CFLAR both interact with multiple shared receptors. One such shared receptor is described by evidence stating that TRAIL binds to recombinant cell-surface-expressed TNFRSF10B, and that TRAIL-induced apoptosis is inhibited by a TNFRSF10B-Fc fusion protein. Which protein is encoded by this specific receptor? | Tumor necrosis factor receptor superfamily member 10B | Medium | convergence | {"qa_id":"medium_convergence_06639","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TNFSF10 and CFLAR both interact with multiple shared receptors. One such shared receptor is described by evidence stating that TRAIL binds to recombinant cel... | |
medium_convergence_06640 | NUDT21 and HDAC1 both interact with a specific shared protein. Evidence indicates that the FG domains of fusion proteins involving this shared entity—specifically PMX1, HOXA9, and HOXC11—exhibit dual binding ability to both CREB binding protein (a coactivator) and histone deacetylase 1 (a corepressor). Which protein is... | Nuclear pore complex protein Nup98-Nup96 | Medium | convergence | {"qa_id":"medium_convergence_06640","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUDT21 and HDAC1 both interact with a specific shared protein. Evidence indicates that the FG domains of fusion proteins involving this shared entity—specifi... | |
medium_convergence_06641 | TNNI3 and ACTN2 share multiple binding partners. One shared partner is described in evidence stating that the bisphosphorylated cTnI arm does not interact with cTnC, but rather with cTnT and/or cTnI. Which protein is encoded by the gene corresponding to this shared partner? | Troponin T, cardiac muscle | Medium | convergence | {"qa_id":"medium_convergence_06641","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TNNI3 and ACTN2 share multiple binding partners. One shared partner is described in evidence stating that the bisphosphorylated cTnI arm does not interact wi... | |
medium_convergence_06642 | SMAD7 and CAV1 both interact with a shared protein. Evidence indicates that this shared protein is an E3 ubiquitin ligase for bone morphogenetic protein-specific Smads, and it interacts with SMAD7 to induce its ubiquitination and translocation into the cytoplasm. Which protein is encoded by the gene corresponding to th... | E3 ubiquitin-protein ligase SMURF1 | Medium | convergence | {"qa_id":"medium_convergence_06642","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD7 and CAV1 both interact with a shared protein. Evidence indicates that this shared protein is an E3 ubiquitin ligase for bone morphogenetic protein-spec... | |
medium_convergence_06643 | Human betaherpesvirus 5 and Human gammaherpesvirus 4 both downregulate a specific shared gene. Experimental data for this gene in a foreskin fibroblast cell line (study GSE130665) reports a log2 fold change of -1.216 and an adjusted p-value of 0.04117. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06643","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human gammaherpesvirus 4 both downregulate a specific shared gene. Experimental data for this gene in a foreskin fibroblast cell ... | |
medium_convergence_06646 | MIR20A and XBP1 are both involved in more than one shared biological process. Evidence concerning one of these shared processes indicates that spliced XBP1 increases smooth muscle cell (SMC) migration via PI3K/Akt activation. Which biological process, connected to this entity through the relation 'positively regulates'... | vascular associated smooth muscle cell migration | Medium | convergence | {"qa_id":"medium_convergence_06646","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MIR20A and XBP1 are both involved in more than one shared biological process. Evidence concerning one of these shared processes indicates that spliced XBP1 i... | |
medium_convergence_06647 | HDAC1 and RUNX1 share a common interaction partner. Evidence indicates that among eight histone deacetylases tested, only the class I HDACs (HDAC-1, HDAC-2, and HDAC-3) bind to this shared entity. Which cellular component is this entity located in? | nuclear matrix | Medium | convergence | {"qa_id":"medium_convergence_06647","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and RUNX1 share a common interaction partner. Evidence indicates that among eight histone deacetylases tested, only the class I HDACs (HDAC-1, HDAC-2, ... | |
medium_convergence_06648 | DAP3 and CASP10 both interact with a shared protein entity. Evidence regarding this entity states: 'We have found that the GTP-binding protein [this entity] binds directly (with high affinity) to the death domain of TNF-related apoptosis-inducing ligand (TRAIL) receptors, and is required for TRAIL-induced apoptosis.' W... | Tumor necrosis factor receptor superfamily member 10A | Medium | convergence | {"qa_id":"medium_convergence_06648","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAP3 and CASP10 both interact with a shared protein entity. Evidence regarding this entity states: 'We have found that the GTP-binding protein [this entity] ... | |
medium_convergence_06649 | MAPK1 and MAPK3 both interact with a specific shared protein. Experimental evidence indicates that activated P-ERK1/2 bind to and phosphorylate this protein at serine residue 216 following p14ARF expression. Which disease is associated with this protein? | leukemia | Medium | convergence | {"qa_id":"medium_convergence_06649","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK1 and MAPK3 both interact with a specific shared protein. Experimental evidence indicates that activated P-ERK1/2 bind to and phosphorylate this protein ... | |
medium_convergence_06650 | CCL11 and CXCL12 both interact with a specific protein. Evidence regarding this protein states: 'Here, we provide evidence that ubiquitin and the cognate [protein] ligand stromal cell-derived factor (SDF)-1α do not share CXCR7 as a receptor.' Which gene encodes this protein? | C-X-C chemokine receptor type 4 | Medium | convergence | {"qa_id":"medium_convergence_06650","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCL11 and CXCL12 both interact with a specific protein. Evidence regarding this protein states: 'Here, we provide evidence that ubiquitin and the cognate [pr... | |
medium_convergence_06651 | HLA-E and XCL1 are both associated with multiple shared biological processes. One of these shared processes is linked to experimental evidence stating that CD8(+) T-cells exhibited cytotoxicity against target cells transfected with the entity only in the presence of a specific peptide. Which biological process is posit... | T cell mediated cytotoxicity | Medium | convergence | {"qa_id":"medium_convergence_06651","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HLA-E and XCL1 are both associated with multiple shared biological processes. One of these shared processes is linked to experimental evidence stating that C... | |
medium_convergence_06653 | EGFR and SH3KBP1 share common interaction partners. One such shared partner is implicated in a study where a specific E3 ubiquitin ligase is recruited to EGFRvIII and inhibits the transformation of NIH 3T3 cells by EGFRvIII. Which protein is encoded by this shared interaction partner? | E3 ubiquitin-protein ligase CBL-B | Medium | convergence | {"qa_id":"medium_convergence_06653","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and SH3KBP1 share common interaction partners. One such shared partner is implicated in a study where a specific E3 ubiquitin ligase is recruited to EGF... | |
medium_convergence_06655 | CSF1R and GRB2 both interact with a common protein. Evidence regarding this shared partner states: 'By using an independent approach, expression cloning, we found that the Grb2 SH3 domains bind specifically to SIP-110, a 110 kDa splice variant of SIP-145 and SIP-130, which lacks the SH2 domain.' Which protein is encode... | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | Medium | convergence | {"qa_id":"medium_convergence_06655","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSF1R and GRB2 both interact with a common protein. Evidence regarding this shared partner states: 'By using an independent approach, expression cloning, we ... | |
medium_convergence_06656 | ACTR1A and COPZ2 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Affinity chromatography experiments demonstrate that a specific protein binds directly to the Arp1 subunit of dynactin.' Which disease is associated with that specific shared partner throu... | cystic fibrosis | Medium | convergence | {"qa_id":"medium_convergence_06656","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ACTR1A and COPZ2 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Affinity chromatography e... | |
medium_convergence_06657 | CAMK2B and CAMK2G each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Loss of PTENα impedes the interaction of CaMKII and a specific NMDA receptor subunit, leading to defects in hippocampal LTP, fear-conditioned memory, and spatial learning.' Which protein ... | Glutamate receptor ionotropic, NMDA 2B | Medium | convergence | {"qa_id":"medium_convergence_06657","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAMK2B and CAMK2G each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Loss of PTENα impedes th... | |
medium_convergence_06658 | CEBPA and ATF2 share a common interaction partner. Evidence indicates that the protein-protein interaction between C/EBPalpha and ASC-2 was detected by coimmunoprecipitation during granulocyte differentiation. Which disease is associated with this shared entity via a biomarker relationship? | small cell lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06658","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPA and ATF2 share a common interaction partner. Evidence indicates that the protein-protein interaction between C/EBPalpha and ASC-2 was detected by coimm... | |
medium_convergence_06660 | WDR5 and PLK1 share multiple interacting partners. One such shared partner has an interaction with PLK1 that was confirmed using a β-galactosidase and growth test in selective media, in vitro glutathione S-transferase pull-down, and in vivo immunoprecipitation assays. Which protein product is encoded by this specific s... | E3 ubiquitin-protein ligase RING2 | Medium | convergence | {"qa_id":"medium_convergence_06660","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WDR5 and PLK1 share multiple interacting partners. One such shared partner has an interaction with PLK1 that was confirmed using a β-galactosidase and growth... | |
medium_convergence_06661 | The androgen receptor (AR) and pyruvate kinase M (PKM) share common interacting partners. One such shared partner is identified by evidence stating: 'Additionally, Co-Immunoprecipitation was conducted to find that Pyruvate kinase isozyme type M2 interacts with this protein, and to further explore their binding and func... | TNF receptor-associated factor 4 | Medium | convergence | {"qa_id":"medium_convergence_06661","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The androgen receptor (AR) and pyruvate kinase M (PKM) share common interacting partners. One such shared partner is identified by evidence stating: 'Additio... | |
medium_convergence_06662 | TRIM28 and AKT1 both interact with a shared protein. Evidence regarding this shared protein states: 'Using pull-down assays and immunoprecipitation, we showed that TIF1beta interacts directly with NGFI-B and with other Nur family members.' Which protein product is encoded by this shared entity? | Nuclear receptor subfamily 4immunitygroup A member 1 | Medium | convergence | {"qa_id":"medium_convergence_06662","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and AKT1 both interact with a shared protein. Evidence regarding this shared protein states: 'Using pull-down assays and immunoprecipitation, we showe... |
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