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medium_convergence_06771 | Both TGFB1 and TGFBR1 interact with a specific protein. Experimental evidence indicates that this protein interacts with TβRI and deubiquitinates TβRI, as revealed by co-immunoprecipitation and ubiquitination assays. Which protein is encoded by the gene corresponding to this interacting entity? | Ubiquitin carboxyl-terminal hydrolase 15 | Medium | convergence | {"qa_id":"medium_convergence_06771","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both TGFB1 and TGFBR1 interact with a specific protein. Experimental evidence indicates that this protein interacts with TβRI and deubiquitinates TβRI, as re... | |
medium_convergence_06772 | Morphine and Palonosetron share a common interacting drug. Evidence indicates that combination treatment with sub-effective doses of this shared entity (0.1 mg/kg) and morphine (0.1 mg/kg) significantly (p < 0.05) exerted an anti-convulsive effect. Which disease is this shared entity indicated for? | cluster headache syndrome | Medium | convergence | {"qa_id":"medium_convergence_06772","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Morphine and Palonosetron share a common interacting drug. Evidence indicates that combination treatment with sub-effective doses of this shared entity (0.1 ... | |
medium_convergence_06773 | H2AX and BRCA1 share multiple binding partners. One such partner contains a COOH-terminal HECT domain that interacts with an NH(2)-terminal degron domain in BRCA1. Which cell type is enriched for this specific partner? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_06773","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H2AX and BRCA1 share multiple binding partners. One such partner contains a COOH-terminal HECT domain that interacts with an NH(2)-terminal degron domain in ... | |
medium_convergence_06774 | PRKN and PCNA share multiple interacting partners. One such shared partner is known to form complexes with D-type cyclins, which are candidate G1 cyclins in mammalian cells. Which protein is encoded by this shared partner? | G1/S-specific cyclin-D1 | Medium | convergence | {"qa_id":"medium_convergence_06774","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and PCNA share multiple interacting partners. One such shared partner is known to form complexes with D-type cyclins, which are candidate G1 cyclins in ... | |
medium_convergence_06775 | MTOR and RICTOR share interaction partners. One such partner is described in evidence stating: 'Here we demonstrate that this partner and P-Rex2 establish, through their tandem DEP domains, interactions with mTOR, suggesting their potential as effectors in the signaling of mTOR to Rac activation and cell migration.' Wh... | lupus vulgaris | Medium | convergence | {"qa_id":"medium_convergence_06775","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MTOR and RICTOR share interaction partners. One such partner is described in evidence stating: 'Here we demonstrate that this partner and P-Rex2 establish, t... | |
medium_convergence_06776 | Both 'regulation of neutrophil mediated cytotoxicity' and 'regulation of microglial cell mediated cytotoxicity' are subtypes of a shared biological process. Evidence regarding one of these subtypes states: 'Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the dir... | myeloid leukocyte mediated immunity | Medium | convergence | {"qa_id":"medium_convergence_06776","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both 'regulation of neutrophil mediated cytotoxicity' and 'regulation of microglial cell mediated cytotoxicity' are subtypes of a shared biological process. ... | |
medium_convergence_06778 | VIRMA and KIF5B share common interaction partners. One such shared partner is implicated in a study stating: 'The major binding site for kinesin light chain in kinesin heavy chain was mapped to residues 789-813 at the C-terminal end of the heavy chain stalk domain.' Which protein encodes the entity described in this ev... | Kinesin light chain 1 | Medium | convergence | {"qa_id":"medium_convergence_06778","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VIRMA and KIF5B share common interaction partners. One such shared partner is implicated in a study stating: 'The major binding site for kinesin light chain ... | |
medium_convergence_06779 | Both histamine production involved in inflammatory response and positive regulation of type 2 immune response are enabled by more than one cell type. One shared cell type is described as a fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted... | band form basophil | Medium | convergence | {"qa_id":"medium_convergence_06779","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both histamine production involved in inflammatory response and positive regulation of type 2 immune response are enabled by more than one cell type. One sha... | |
medium_convergence_06780 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.222 and an adjusted p-value of 0.01915. Which protein is encoded by this gene? | Transgelin | Medium | convergence | {"qa_id":"medium_convergence_06780","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (st... | |
medium_convergence_06781 | ANAPC4 and ANAPC1 both interact with a specific protein. Evidence regarding this protein indicates that while mutants in both motifs assemble the Mitotic Checkpoint Complex (MCC) normally, the integrity of the IR motif is particularly important for stable binding to the APC/C. Which protein is encoded by the gene corre... | Cell division cycle protein 20 homolog | Medium | convergence | {"qa_id":"medium_convergence_06781","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC4 and ANAPC1 both interact with a specific protein. Evidence regarding this protein indicates that while mutants in both motifs assemble the Mitotic Che... | |
medium_convergence_06782 | Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus both downregulate a specific gene. Evidence for this shared target in gamma delta T-lymphocytes (from study GSE13906) reports a log2 fold change of -1.086 and an adjusted p-value of 0.03811. Which protein is encoded by this gene? | Microfibrillar-associated protein 2 | Medium | convergence | {"qa_id":"medium_convergence_06782","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus both downregulate a specific gene. Evidence for this shared target in gamm... | |
medium_convergence_06784 | GATA1 and GATA2 both interact with a specific transcription factor. Evidence regarding this factor states: 'In addition to known TAL-1 partners, GATA-1, E2A, HEB, LMO2 and Ldb1, we identify the ETO2 repressor as a novel component recruited to TAL-1 complexes through interaction with E2A/HEB.' Which disease is associate... | leukemia, acute lymphocytic, susceptibility to, 1 | Medium | convergence | {"qa_id":"medium_convergence_06784","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GATA1 and GATA2 both interact with a specific transcription factor. Evidence regarding this factor states: 'In addition to known TAL-1 partners, GATA-1, E2A,... | |
medium_convergence_06785 | CBX5 and ASF1A share a common interaction partner. Evidence indicates that this partner (specifically identified as the p150 subunit of the chromatin assembly factor complex in the context of binding the PxVxL motif to the CSD) is involved in heterochromatin maintenance. Which disease is associated with this shared int... | leukemia | Medium | convergence | {"qa_id":"medium_convergence_06785","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX5 and ASF1A share a common interaction partner. Evidence indicates that this partner (specifically identified as the p150 subunit of the chromatin assembl... | |
medium_convergence_06786 | EFNA4 and EFNA5 both interact with a specific receptor tyrosine kinase. Evidence indicates that ephrin-A2, ephrin-A3, and ephrin-A5 bind to this receptor, but they do not bind to EFNA4. Which disease is associated with this receptor? | dental caries | Medium | convergence | {"qa_id":"medium_convergence_06786","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EFNA4 and EFNA5 both interact with a specific receptor tyrosine kinase. Evidence indicates that ephrin-A2, ephrin-A3, and ephrin-A5 bind to this receptor, bu... | |
medium_convergence_06788 | CENPS and CENPQ each interact with more than one shared protein partner. Evidence concerning one such shared partner reports that Fluorescent two-hybrid analysis identified a uniquely strong CENP-S binding protein, an association confirmed by FRET, revealing a centromere-bound complex containing CENP-S, CENP-X, and tha... | Centromere protein T | Medium | convergence | {"qa_id":"medium_convergence_06788","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPS and CENPQ each interact with more than one shared protein partner. Evidence concerning one such shared partner reports that Fluorescent two-hybrid anal... | |
medium_convergence_06790 | CDKN1A and RB1 share common interaction partners. One such shared partner is involved in a mechanism where p21 recognizes CDK/cyclin complexes, at least in part, through a protein-protein interaction with a binding groove on the cyclin subunit. Which protein is encoded by this shared interaction partner? | Cyclin-A1 | Medium | convergence | {"qa_id":"medium_convergence_06790","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN1A and RB1 share common interaction partners. One such shared partner is involved in a mechanism where p21 recognizes CDK/cyclin complexes, at least in p... | |
medium_convergence_06791 | TCF4 and TCF3 both interact with a specific shared protein. Experimental evidence indicates that missense mutations in the helical domains of this protein result in a complete loss of heterodimerization with the E12 bHLH protein in a two-hybrid system. Which protein product is encoded by this shared interacting partner... | Twist-related protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06791","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TCF4 and TCF3 both interact with a specific shared protein. Experimental evidence indicates that missense mutations in the helical domains of this protein re... | |
medium_convergence_06792 | PPP2CA and PPP2R1A both interact with a shared protein partner. Evidence regarding this partner notes: 'Similar chromatographic profiles were also observed for the heterotrimer reconstituted from recombinant A alpha, purified B and C, and the native bovine cardiac heterotrimeric holoenzyme.' Which disease is associated... | urinary bladder carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06792","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP2CA and PPP2R1A both interact with a shared protein partner. Evidence regarding this partner notes: 'Similar chromatographic profiles were also observed f... | |
medium_convergence_06793 | CHEK1 and ATR both interact with a shared protein. Evidence indicates that this protein localizes to the nucleus but only associates with Chk1 following replication stress or other types of DNA damage. Which disease is associated with this protein? | telangiectasis | Medium | convergence | {"qa_id":"medium_convergence_06793","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and ATR both interact with a shared protein. Evidence indicates that this protein localizes to the nucleus but only associates with Chk1 following repl... | |
medium_convergence_06794 | MCM10 and CDC6 both interact with a shared protein partner. Experimental evidence indicates that HsMcm10 associates with the human version of this partner protein when overexpressed in COS-1 cells. Which protein is encoded by the gene corresponding to this shared partner? | Origin recognition complex subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_06794","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM10 and CDC6 both interact with a shared protein partner. Experimental evidence indicates that HsMcm10 associates with the human version of this partner pr... | |
medium_convergence_06795 | PAK4 and ARHGDIA both interact with a specific protein. Evidence regarding this protein states: 'The newly discovered [protein] interacted very poorly with Rho-GDI.' Which protein product is encoded by this gene? | Rho-related GTP-binding protein RhoH | Medium | convergence | {"qa_id":"medium_convergence_06795","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PAK4 and ARHGDIA both interact with a specific protein. Evidence regarding this protein states: 'The newly discovered [protein] interacted very poorly with R... | |
medium_convergence_06796 | Both TNK2 and CDK9 interact with a common protein. Evidence regarding this shared partner states: 'Here we show that ACK1 directly binds and phosphorylates the Arp2/3 regulatory protein [shared partner], potentially providing a direct link to Arp2/3-based actin dynamics during EGFR degradation.' Which protein is encode... | Src substrate cortactin | Medium | convergence | {"qa_id":"medium_convergence_06796","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both TNK2 and CDK9 interact with a common protein. Evidence regarding this shared partner states: 'Here we show that ACK1 directly binds and phosphorylates t... | |
medium_convergence_06797 | DCTN1 and COPG1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Phosphorylation also enhanced the specific binding of p150(Glued) to the tail domain of HsEg5 in vitro, indicating that the two proteins are able to interact directly.' Which disease is con... | microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability | Medium | convergence | {"qa_id":"medium_convergence_06797","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCTN1 and COPG1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Phosphorylation also enhan... | |
medium_convergence_06798 | CRY1 and NONO both interact with a specific protein. Evidence indicates that this protein, along with CRY1 and/or CRY2, engages in light-independent interactions with CLOCK, BMAL1, and TIM. Which protein is encoded by the gene corresponding to this interacting partner? | Period circadian protein homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_06798","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRY1 and NONO both interact with a specific protein. Evidence indicates that this protein, along with CRY1 and/or CRY2, engages in light-independent interact... | |
medium_convergence_06799 | CREBBP and ELOB each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In the mammalian two-hybrid system, CAD and NAD baits enhanced the luciferase expression from a reporter gene by co-transfection with CREB-binding protein (CBP) prey, whereas CAD, but not NAD, e... | Hypoxia-inducible factor 1-alpha | Medium | convergence | {"qa_id":"medium_convergence_06799","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and ELOB each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In the mammalian two-hybrid sys... | |
medium_convergence_06800 | EXOC8 and ASAP1 both interact with a shared protein partner. Experimental evidence indicates that this partner directly binds to FIP3 via its BAR domain, as confirmed by coimmunoprecipitation and in vitro pulldown assays. Which protein is encoded by the gene corresponding to this shared partner? | Rab11 family-interacting protein 3 | Medium | convergence | {"qa_id":"medium_convergence_06800","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EXOC8 and ASAP1 both interact with a shared protein partner. Experimental evidence indicates that this partner directly binds to FIP3 via its BAR domain, as ... | |
medium_convergence_06801 | BRD8 and RUVBL1 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we report the identification of a specific protein as an interacting partner of Pontin52.' Which protein is encoded by the gene corresponding to that shared entity? | RuvB-like 2 | Medium | convergence | {"qa_id":"medium_convergence_06801","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD8 and RUVBL1 each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we report the identificati... | |
medium_convergence_06802 | FANCA and FANCD2 both interact with a specific protein. Evidence regarding this protein states: 'We found that the protein(-/-) cells expressing UBZ-deficient versions of the protein were selectively sensitive to ICL-inducing agents, and that the UBZ domain was required for interaction of the protein with ubiquitylated... | Structure-specific endonuclease subunit SLX4 | Medium | convergence | {"qa_id":"medium_convergence_06802","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCA and FANCD2 both interact with a specific protein. Evidence regarding this protein states: 'We found that the protein(-/-) cells expressing UBZ-deficien... | |
medium_convergence_06803 | NCOA6 and PSMC5 both interact with a specific protein. Evidence indicates that mSUG1 (P45), a component of the 26S proteasome, interacts in a 1,25-(OH)2D3-dependent manner with the AF-2 domain of this protein. Which protein is encoded by the gene corresponding to this protein? | Vitamin D3 receptor | Medium | convergence | {"qa_id":"medium_convergence_06803","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCOA6 and PSMC5 both interact with a specific protein. Evidence indicates that mSUG1 (P45), a component of the 26S proteasome, interacts in a 1,25-(OH)2D3-de... | |
medium_convergence_06804 | RNF31 and IKBKE both interact with a specific shared protein. Evidence indicates that this shared protein interacts via its PUB domain with CYLD, and that a PUB interaction motif (PIM) within this protein binds to the PUB domain of the LUBAC component HOIP. Which protein is encoded by the gene corresponding to this sha... | Spermatogenesis-associated protein 2 | Medium | convergence | {"qa_id":"medium_convergence_06804","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RNF31 and IKBKE both interact with a specific shared protein. Evidence indicates that this shared protein interacts via its PUB domain with CYLD, and that a ... | |
medium_convergence_06806 | CAND1 and CUL1 each interact with more than one shared protein. Evidence concerning one shared entity reports that it contains an F-box domain and is associated with the proteins Skp1, Roc-1, and Cullin-1, suggesting that it is a component of an SCF ubiquitination complex. Which disease is connected to that entity thro... | intellectual disability, autosomal recessive 45 | Medium | convergence | {"qa_id":"medium_convergence_06806","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAND1 and CUL1 each interact with more than one shared protein. Evidence concerning one shared entity reports that it contains an F-box domain and is associa... | |
medium_convergence_06807 | EZH2 and EED both interact with a specific protein. Evidence indicates that this protein associates with the PRC2 complex and stimulates its enzymatic activity in vitro. Which protein is encoded by the gene corresponding to this interacting entity? | Protein Jumonji | Medium | convergence | {"qa_id":"medium_convergence_06807","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EZH2 and EED both interact with a specific protein. Evidence indicates that this protein associates with the PRC2 complex and stimulates its enzymatic activi... | |
medium_convergence_06808 | Both Human immunodeficiency virus 1 and Orthohepevirus A are known to downregulate a specific host gene. In a study of macrophages (GSE108897), the expression of this gene was found to have a log2 fold change of -1.495 and an adjusted p-value of 0.02057. Which cellular component is this gene located in? | membrane | Medium | convergence | {"qa_id":"medium_convergence_06808","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Orthohepevirus A are known to downregulate a specific host gene. In a study of macrophages (GSE108897), the expressio... | |
medium_convergence_06809 | GSK3B and MDM2 share multiple interacting partners. One such shared partner functions as a stress sensor that interacts with the E3 ligase MDM2 to suppress SLUG degradation in alveolar epithelial type 2 (AEC2) cells by impeding MDM2-catalyzed SLUG ubiquitination. Which disease is associated with this specific shared pa... | thymoma | Medium | convergence | {"qa_id":"medium_convergence_06809","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GSK3B and MDM2 share multiple interacting partners. One such shared partner functions as a stress sensor that interacts with the E3 ligase MDM2 to suppress S... | |
medium_convergence_06811 | Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 2.96 and an adjusted p-value of 0.0055. Which protein is encoded by this gene? | Endothelin-1 | Medium | convergence | {"qa_id":"medium_convergence_06811","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) rep... | |
medium_convergence_06812 | CCT2 and LRRK2 share common interaction partners. One such shared partner has been shown to form a heterodimer with LRRK2. Which biological process is this shared partner involved in? | positive regulation of canonical Wnt signaling pathway | Medium | convergence | {"qa_id":"medium_convergence_06812","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCT2 and LRRK2 share common interaction partners. One such shared partner has been shown to form a heterodimer with LRRK2. Which biological process is this s... | |
medium_convergence_06813 | RAB4A and YWHAZ share multiple interacting partners. One such partner is described in evidence stating: 'We have identified a novel 80-kDa protein that interacts specifically with the GTP-bound conformation of Rab4, and subsequent work has shown that it also interacts strongly with Rab11.' Which protein is encoded by t... | Rab11 family-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06813","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAB4A and YWHAZ share multiple interacting partners. One such partner is described in evidence stating: 'We have identified a novel 80-kDa protein that inter... | |
medium_convergence_06814 | YAP1 and IGF2BP1 share multiple protein interaction partners. One such shared partner is known to interact directly with YAP1 via a WB motif-WW domain interaction. Which protein is encoded by the gene corresponding to this shared partner? | Poly(rC)-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_06814","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and IGF2BP1 share multiple protein interaction partners. One such shared partner is known to interact directly with YAP1 via a WB motif-WW domain intera... | |
medium_convergence_06815 | NEDD4L and HSPA4 both interact with a specific protein. Evidence indicates that this protein, along with Cav3 and the ubiquitin ligase Nedd4-2, forms a complex. Which protein is encoded by the gene corresponding to this shared interaction partner? | Voltage-gated inwardly rectifying potassium channel KCNH2 | Medium | convergence | {"qa_id":"medium_convergence_06815","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4L and HSPA4 both interact with a specific protein. Evidence indicates that this protein, along with Cav3 and the ubiquitin ligase Nedd4-2, forms a compl... | |
medium_convergence_06816 | HDAC2 and MBD3 share multiple binding partners. One such partner is part of a complex that contains HDAC1/2, RbAp46/48, and the partner itself, but explicitly excludes Sin3 and Mi2. Which protein is encoded by this partner? | Metastasis-associated protein MTA1 | Medium | convergence | {"qa_id":"medium_convergence_06816","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC2 and MBD3 share multiple binding partners. One such partner is part of a complex that contains HDAC1/2, RbAp46/48, and the partner itself, but explicitl... | |
medium_convergence_06817 | EIF1AX and EIF3B each interact with more than one shared protein. Evidence concerning one of these shared entities states that activating mTOR signaling with insulin increased the amount of a translation initiation factor bound to eIF3 by as much as five-fold. Which protein is connected to that entity through the 'enco... | Eukaryotic translation initiation factor 4 gamma 1 | Medium | convergence | {"qa_id":"medium_convergence_06817","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF1AX and EIF3B each interact with more than one shared protein. Evidence concerning one of these shared entities states that activating mTOR signaling with... | |
medium_convergence_06819 | PPHLN1 and ATF7IP share a common binding partner. Evidence regarding this shared entity states: 'Immunoprecipitation and in vitro binding analyses reveal that both MCAF proteins interact with MBD1, this shared entity, and Sp1 via two evolutionarily conserved distinct domains.' Which protein is encoded by this shared en... | Histone-lysine N-methyltransferase SETDB1 | Medium | convergence | {"qa_id":"medium_convergence_06819","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPHLN1 and ATF7IP share a common binding partner. Evidence regarding this shared entity states: 'Immunoprecipitation and in vitro binding analyses reveal tha... | |
medium_convergence_06820 | DSC3 and DSP each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In extracts from HaCaT cells, distinct soluble complexes containing PKP1a and desmoplakin I (DPI) have been identified by co-immunoprecipitation and sucrose density fractionation.' Which disease is connected to... | prostate cancer | Medium | convergence | {"qa_id":"medium_convergence_06820","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DSC3 and DSP each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In extracts from HaCaT cells, distinct soluble ... | |
medium_convergence_06821 | EP300 and JUN both interact with a specific shared protein. Evidence indicates that Erk activation enhances the association of this protein with p300 and Smad1. Which protein is encoded by the gene corresponding to this shared entity? | Runt-related transcription factor 2 | Medium | convergence | {"qa_id":"medium_convergence_06821","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and JUN both interact with a specific shared protein. Evidence indicates that Erk activation enhances the association of this protein with p300 and Sma... | |
medium_convergence_06824 | TP53 and UBE2D2 share multiple interacting partners. One such shared partner is a gene whose transcription is promoted by the nuclear lncRNA LINC00355, acting as a transcriptional activator. This gene product, along with RAD18, binds to P53 and mediates its ubiquitination and degradation. Which disease is associated wi... | neurodevelopmental disorder with absent speech and movement and behavioral abnormalities | Medium | convergence | {"qa_id":"medium_convergence_06824","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TP53 and UBE2D2 share multiple interacting partners. One such shared partner is a gene whose transcription is promoted by the nuclear lncRNA LINC00355, actin... | |
medium_convergence_06825 | GNAQ and GRIK3 both interact with a common protein partner. Experimental evidence confirms complex formation between G alpha(q) and PLC beta1 in vitro and in living PC12 and HEK293 cells using fluorescence resonance energy transfer. Which disease is associated with this specific protein partner? | developmental and epileptic encephalopathy, 12 | Medium | convergence | {"qa_id":"medium_convergence_06825","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAQ and GRIK3 both interact with a common protein partner. Experimental evidence confirms complex formation between G alpha(q) and PLC beta1 in vitro and in... | |
medium_convergence_06826 | CRKL and ERBB3 both interact with a shared protein. Experimental evidence indicates that this shared protein binds directly to the regulatory subunit of PI3K in vitro, as demonstrated by Far Western blotting using a fusion protein containing the SH3 domain of CRKL. Which disease is associated with this shared protein t... | megalencephaly | Medium | convergence | {"qa_id":"medium_convergence_06826","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRKL and ERBB3 both interact with a shared protein. Experimental evidence indicates that this shared protein binds directly to the regulatory subunit of PI3K... | |
medium_convergence_06827 | CSNK2A1 and FBXL6 share a common interaction partner. Evidence regarding one such partner states: 'We demonstrate that casein kinase 2 (CKII) from HeLa cell nuclear extracts interacts with immobilized NAP-II, and phosphorylates both NAP-2 and nucleosome assembly protein 1 (NAP-1) in vitro.' Which protein is encoded by ... | Nucleosome assembly protein 1-like 4 | Medium | convergence | {"qa_id":"medium_convergence_06827","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and FBXL6 share a common interaction partner. Evidence regarding one such partner states: 'We demonstrate that casein kinase 2 (CKII) from HeLa cell ... | |
medium_convergence_06828 | Both CHEK1 and ESCO2 interact with a shared protein. A study explicitly identifies damaged DNA-binding protein 1 as a novel Chk1-interacting protein. Which disease is associated with this specific shared protein? | White-Kernohan syndrome | Medium | convergence | {"qa_id":"medium_convergence_06828","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both CHEK1 and ESCO2 interact with a shared protein. A study explicitly identifies damaged DNA-binding protein 1 as a novel Chk1-interacting protein. Which d... | |
medium_convergence_06829 | MAPK8IP3 and GEMIN5 share a common interaction partner. Evidence regarding this shared partner states: 'In similar cotransfection studies, JSAP1 also interacted with a MAPKK and MEKK1 MAPKKK, which are involved in the JNK cascades.' Which protein is encoded by this shared interaction partner? | Dual specificity mitogen-activated protein kinase kinase 4 | Medium | convergence | {"qa_id":"medium_convergence_06829","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK8IP3 and GEMIN5 share a common interaction partner. Evidence regarding this shared partner states: 'In similar cotransfection studies, JSAP1 also interac... | |
medium_convergence_06830 | Zaire ebolavirus and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE100839) reports a log2 fold change of approximately -1.249 and an adjusted p-value of 0.03269. Which protein is encoded by this gene? | Pleckstrin homology-like domain family A member 1 | Medium | convergence | {"qa_id":"medium_convergence_06830","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Human gammaherpesvirus 8 both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (s... | |
medium_convergence_06831 | EP300 and RPS6 share interaction partners. One such partner is described by the evidence: 'Following mitogen stimulation, S6Ks interact with the p300 and p300/CBP-associated factor (PCAF) acetyltransferases.' Which protein is encoded by the gene corresponding to this shared interaction partner? | Ribosomal protein S6 kinase beta-2 | Medium | convergence | {"qa_id":"medium_convergence_06831","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and RPS6 share interaction partners. One such partner is described by the evidence: 'Following mitogen stimulation, S6Ks interact with the p300 and p30... | |
medium_convergence_06832 | ESR1 and HDAC2 share multiple interacting partners. One such partner is a protein whose interaction with HDAC2 is inhibited by ATRA-induced phosphorylation of HDAC2 at Ser424 in vascular smooth muscle cells. Which protein is encoded by the gene corresponding to this interacting partner? | Krueppel-like factor 4 | Medium | convergence | {"qa_id":"medium_convergence_06832","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HDAC2 share multiple interacting partners. One such partner is a protein whose interaction with HDAC2 is inhibited by ATRA-induced phosphorylation o... | |
medium_convergence_06833 | CHEK2 and FAM175A share a common binding partner. Evidence indicates that the interaction between CHEK2 and this shared partner is mediated by the partner's FHA domain and the phosphorylated Thr 68 residue of CHEK2. Which disease is associated with this shared partner via a biomarker relationship? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06833","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK2 and FAM175A share a common binding partner. Evidence indicates that the interaction between CHEK2 and this shared partner is mediated by the partner's ... | |
medium_convergence_06834 | FUS and PPP1CA share interaction partners. One such shared partner is part of a stable multimeric complex described as the PTW/PP1 phosphatase complex, which consists of the regulatory subunits PNUTS, the shared partner, and a PP1 catalytic subunit. Which protein is encoded by this shared partner? | WD repeat-containing protein 82 | Medium | convergence | {"qa_id":"medium_convergence_06834","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FUS and PPP1CA share interaction partners. One such shared partner is part of a stable multimeric complex described as the PTW/PP1 phosphatase complex, which... | |
medium_convergence_06835 | FAM175A and BABAM2 each share a binding partner with ABRAXAS1. Evidence indicates that ABRAXAS1 and this shared partner associate through coiled-coil domains on each protein. Which disease is associated with this shared partner? | leiomyoma | Medium | convergence | {"qa_id":"medium_convergence_06835","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAM175A and BABAM2 each share a binding partner with ABRAXAS1. Evidence indicates that ABRAXAS1 and this shared partner associate through coiled-coil domains... | |
medium_convergence_06836 | MDM2 and MYC share multiple interacting partners. One such shared partner is characterized by evidence stating that its N-terminal region binds to the central acidic domain of MDM2. Which cellular component is this shared partner located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_06836","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and MYC share multiple interacting partners. One such shared partner is characterized by evidence stating that its N-terminal region binds to the centra... | |
medium_convergence_06837 | EXOSC6 and NCBP2 share multiple binding partners. One of these shared partners is a protein that binds the cap-binding complex (CBC), which is universally present on capped RNAs, and also associates with the nuclear exosome targeting (NEXT) complex, thereby linking to RNA decay. Which biological process is this specifi... | RNA destabilization | Medium | convergence | {"qa_id":"medium_convergence_06837","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EXOSC6 and NCBP2 share multiple binding partners. One of these shared partners is a protein that binds the cap-binding complex (CBC), which is universally pr... | |
medium_convergence_06838 | TOPORS and KDM1A each interact with more than one shared protein. Evidence concerning one of these shared entities reports: 'The interaction between endogenous TOPORS and P26s4 proteins was validated by co-immuno-precipitation from mammalian cell extracts and further characterised by immunofluorescent co-localisation s... | 26S proteasome regulatory subunit 4 | Medium | convergence | {"qa_id":"medium_convergence_06838","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPORS and KDM1A each interact with more than one shared protein. Evidence concerning one of these shared entities reports: 'The interaction between endogeno... | |
medium_convergence_06839 | RGCC and TGFB1 are both involved in more than one shared biological process. Evidence indicates that one of these shared processes is linked to RGC-32, which stimulates apoptosis as demonstrated by increased apoptotic cells and caspase-3 cleavage. Which biological process is positively regulated by this specific shared... | endothelial cell apoptotic process | Medium | convergence | {"qa_id":"medium_convergence_06839","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RGCC and TGFB1 are both involved in more than one shared biological process. Evidence indicates that one of these shared processes is linked to RGC-32, which... | |
medium_convergence_06840 | AKAP11 and PRKN (PARK2) share interaction partners. One such shared partner is implicated by evidence stating that Anti-hAKAP220 antisera coimmunoprecipitated both type I and type II regulatory subunits of PKA in human testis lysates, indicating that hAKAP220 interacts with both classes of R subunits. Which disease is ... | neonatal severe primary hyperparathyroidism | Medium | convergence | {"qa_id":"medium_convergence_06840","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKAP11 and PRKN (PARK2) share interaction partners. One such shared partner is implicated by evidence stating that Anti-hAKAP220 antisera coimmunoprecipitate... | |
medium_convergence_06841 | DSC1 and DSG1 share a common binding partner. Experimental evidence indicates that in in vitro overlay assays, the head domain of this shared binding partner specifically associates with itself and with desmocollin 1a. Which protein is encoded by the gene corresponding to this shared binding partner? | Desmoplakin | Medium | convergence | {"qa_id":"medium_convergence_06841","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DSC1 and DSG1 share a common binding partner. Experimental evidence indicates that in in vitro overlay assays, the head domain of this shared binding partner... | |
medium_convergence_06842 | Human alphaherpesvirus 1 and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.017 and an adjusted p-value of approximately 0.01038. Which disease is associated with this gene as a biomarker? | systemic lupus erythematosus | Medium | convergence | {"qa_id":"medium_convergence_06842","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE11496... | |
medium_convergence_06844 | CREBBP and HDAC2 both interact with a shared transcription factor. Evidence regarding this shared entity states: 'We show here that the transcriptional co-activators CBP/p300 bind to and control the activity of the inducible N-terminal transactivation domain of this factor, TAD-A.' Which cell type is this shared entity... | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_06844","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and HDAC2 both interact with a shared transcription factor. Evidence regarding this shared entity states: 'We show here that the transcriptional co-ac... | |
medium_convergence_06845 | Interferon beta-1a and Cyclosporine both interact with a specific drug. Evidence regarding this drug states: 'These effects of cyclosporine and gemfibrozil explain the increased plasma statin concentrations and, together with pharmacodynamic factors, the increased risk of myotoxicity when coadministered with statins.' ... | Familial type 3 hyperlipoproteinemia | Medium | convergence | {"qa_id":"medium_convergence_06845","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Interferon beta-1a and Cyclosporine both interact with a specific drug. Evidence regarding this drug states: 'These effects of cyclosporine and gemfibrozil e... | |
medium_convergence_06846 | SIN3A and HDAC1 share a common interacting partner. Evidence indicates that this partner is a native subunit of a repressive mSin3a-HDAC1 histone deacetylase complex and binds with high affinity to trimethylated species. Which disease is associated with this entity via a biomarker relationship? | glioma | Medium | convergence | {"qa_id":"medium_convergence_06846","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and HDAC1 share a common interacting partner. Evidence indicates that this partner is a native subunit of a repressive mSin3a-HDAC1 histone deacetylase... | |
medium_convergence_06847 | FGF1 and FGF10 both interact with a specific fibroblast growth factor receptor. Evidence regarding this receptor states: 'Within each 1:1 FGF:FGFR complex, heparin makes numerous contacts with both FGF and FGFR, thereby augmenting FGF-FGFR binding.' Which protein is encoded by the gene corresponding to this receptor? | Fibroblast growth factor receptor 1 | Medium | convergence | {"qa_id":"medium_convergence_06847","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGF1 and FGF10 both interact with a specific fibroblast growth factor receptor. Evidence regarding this receptor states: 'Within each 1:1 FGF:FGFR complex, h... | |
medium_convergence_06848 | ATG14 and HLA-F share common interaction partners. One such shared partner interacts with Beclin 1 and a class III phosphatidylinositol 3-kinase catalytic subunit, similar to UVRAG, but unlike UVRAG, it is not present in the same complex as UVRAG. Which disease is associated with this shared partner as a biomarker? | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_06848","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATG14 and HLA-F share common interaction partners. One such shared partner interacts with Beclin 1 and a class III phosphatidylinositol 3-kinase catalytic su... | |
medium_convergence_06850 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific shared gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.101 and an adjusted p-value of 3.622e-05. Which cell type is ... | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_06850","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are known to downregulate a specific shared gene. Experimental data f... | |
medium_convergence_06852 | DDX49 and IMP3 both interact with a shared protein partner. Evidence indicates that this partner, along with DDX49 and IMP3, forms a stable hetero-trimeric complex in vitro through direct interactions. Which protein is encoded by this shared partner? | U3 small nucleolar ribonucleoprotein protein MPP10 | Medium | convergence | {"qa_id":"medium_convergence_06852","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDX49 and IMP3 both interact with a shared protein partner. Evidence indicates that this partner, along with DDX49 and IMP3, forms a stable hetero-trimeric c... | |
medium_convergence_06853 | TP53 and CUL4B both interact with a shared protein. Experimental evidence indicates that this shared protein interacts with DDB1, and this binding is enhanced by the phosphorylated N-terminal domain of CUL4B. Which protein is encoded by the gene corresponding to this shared entity? | WD repeat-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06853","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TP53 and CUL4B both interact with a shared protein. Experimental evidence indicates that this shared protein interacts with DDB1, and this binding is enhance... | |
medium_convergence_06854 | IL1R1 and IKBKG share multiple binding partners. One shared partner is described by evidence stating: 'When human embryonic kidney cells (cell line 293) over-expressing IL-1RI or HeLa cells were exposed to IL-1, a kinase rapidly associated with the IL-1RI complex and was phosphorylated.' Which protein is encoded by the... | Interleukin-1 receptor-associated kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_06854","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL1R1 and IKBKG share multiple binding partners. One shared partner is described by evidence stating: 'When human embryonic kidney cells (cell line 293) over... | |
medium_convergence_06855 | Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of 1.919 and an adjusted p-value of 0.04374. Which protein does this gene product interact with? | YIPF3 | Medium | convergence | {"qa_id":"medium_convergence_06855","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for this gene in renal epithelial cells (study GSE135833) r... | |
medium_convergence_06856 | CDC37 and CRK both interact with a specific kinase. Evidence indicates that this kinase binds to the first SH3 domain of Crk and phosphorylates c-Crk on tyrosine 221 (Y221), identifying the kinase as c-Abl. Which disease is associated with this kinase through genomic alterations? | MELAS syndrome | Medium | convergence | {"qa_id":"medium_convergence_06856","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and CRK both interact with a specific kinase. Evidence indicates that this kinase binds to the first SH3 domain of Crk and phosphorylates c-Crk on tyro... | |
medium_convergence_06857 | EHHADH and IRAK1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we show that, before IL-1beta treatment, this protein is present in a complex with IRAK, and that recruitment of this protein-IRAK complexes to the activated receptor complex occurs through association... | asthma | Medium | convergence | {"qa_id":"medium_convergence_06857","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHHADH and IRAK1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we show that, before IL-1beta treatmen... | |
medium_convergence_06858 | Both Measles morbillivirus and Influenza A virus are associated with the downregulation of a specific gene. Experimental data for this gene reports a log2 fold change of approximately -1.564 and an adjusted p-value of 0.002502. Which protein is encoded by this gene? | V-type proton ATPase subunit e 2 | Medium | convergence | {"qa_id":"medium_convergence_06858","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus are associated with the downregulation of a specific gene. Experimental data for this gene reports a log2 fo... | |
medium_convergence_06859 | Both Measles morbillivirus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene in pleural mesothelioma cells (from study GSE117668) reports a log2 fold change of approximately -1.146 and an adjusted p-value of 0.03519. Which disease is genetically associated with this... | prostate cancer | Medium | convergence | {"qa_id":"medium_convergence_06859","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene in pleural mesothelioma ce... | |
medium_convergence_06860 | CBX3 and DAXX both interact with a specific shared protein. Experimental evidence indicates that this protein, when FLAG-tagged in HCT116 cells, specifically associates with HP1γ (but not HP1α or HP1β) via its chromo-shadow domain. Which protein is encoded by the gene corresponding to this shared entity? | Homeodomain-interacting protein kinase 2 | Medium | convergence | {"qa_id":"medium_convergence_06860","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and DAXX both interact with a specific shared protein. Experimental evidence indicates that this protein, when FLAG-tagged in HCT116 cells, specifically... | |
medium_convergence_06861 | Both Influenza A virus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line reports a log2 fold change of approximately 1.28 and an adjusted p-value of approximately 0.00042. Which cellular component is this gene located in? | extracellular space | Medium | convergence | {"qa_id":"medium_convergence_06861","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Cardiovirus A are known to upregulate a specific shared gene. Experimental data for this gene in a non-small cell lung adenocarcin... | |
medium_convergence_06862 | EEF1A1 and EP300 share multiple interacting partners. One such partner is reported to form a protein complex with p300 that binds to the ORMDL3 promoter, as demonstrated by Immunoprecipitation and ChIP/Re-ChIP assays. Which cellular component is this specific partner located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_06862","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EEF1A1 and EP300 share multiple interacting partners. One such partner is reported to form a protein complex with p300 that binds to the ORMDL3 promoter, as ... | |
medium_convergence_06863 | ERBB2 and ERBB4 both interact with a specific protein. Evidence regarding this interaction states: 'In this study, we show that Abl kinase SH2 domains bind directly to Her-2, and like PDGFR-beta, Her-2 directly phosphorylates c-Abl.' Which protein is encoded by the gene corresponding to this interacting partner? | Tyrosine-protein kinase ABL2 | Medium | convergence | {"qa_id":"medium_convergence_06863","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and ERBB4 both interact with a specific protein. Evidence regarding this interaction states: 'In this study, we show that Abl kinase SH2 domains bind d... | |
medium_convergence_06864 | MRGBP and RUVBL1 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'Here, we report the identification of a specific protein as an interacting partner of Pontin52.' Which protein is encoded by this shared interaction partner? | RuvB-like 2 | Medium | convergence | {"qa_id":"medium_convergence_06864","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MRGBP and RUVBL1 both interact with a specific protein. Evidence regarding this shared interaction partner states: 'Here, we report the identification of a s... | |
medium_convergence_06865 | ARPC2 and CDC42 share a common interaction partner. Experimental evidence regarding this partner indicates that mutations such as V42A and L174A cause large, selective changes in binding to specific CRIB effectors. Specifically, neither mutation alters PAK binding, both severely disrupt binding to ACK, and only the L17... | Actin nucleation-promoting factor WAS | Medium | convergence | {"qa_id":"medium_convergence_06865","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC2 and CDC42 share a common interaction partner. Experimental evidence regarding this partner indicates that mutations such as V42A and L174A cause large,... | |
medium_convergence_06866 | Prednisolone and Methylprednisolone share a common interacting drug. Clinical evidence regarding this shared entity states: 'Administration of prednisolone (0.5 mg/kg/day) as well as the addition of azathioprine failed to suppress the deterioration.' Which drug interacts with this shared entity? | Deflazacort | Medium | convergence | {"qa_id":"medium_convergence_06866","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Prednisolone and Methylprednisolone share a common interacting drug. Clinical evidence regarding this shared entity states: 'Administration of prednisolone (... | |
medium_convergence_06867 | EP300 and RBPJ share multiple interacting partners. One such partner is characterized by evidence stating it forms a complex, primarily with p300, independent of DNA presence. Which cell type is this partner enriched in? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | convergence | {"qa_id":"medium_convergence_06867","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and RBPJ share multiple interacting partners. One such partner is characterized by evidence stating it forms a complex, primarily with p300, independen... | |
medium_convergence_06869 | AMOTL1 and TEAD1 both interact with a shared protein partner. Contextual evidence states: 'Mechanistically we found that phosphofructokinase (PFK1), the enzyme regulating the first committed step of glycolysis, binds the YAP/TAZ transcriptional cofactors TEADs and promotes their functional and biochemical cooperation w... | Transcriptional coactivator YAP1 | Medium | convergence | {"qa_id":"medium_convergence_06869","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AMOTL1 and TEAD1 both interact with a shared protein partner. Contextual evidence states: 'Mechanistically we found that phosphofructokinase (PFK1), the enzy... | |
medium_convergence_06870 | PIGA and DPM2 each interact with more than one shared protein. One such shared protein is PIG-P, a 134-amino acid protein with two hydrophobic domains that associates with PIG-A and GPI1. Which disease is associated with this specific protein? | developmental and epileptic encephalopathy, 55 | Medium | convergence | {"qa_id":"medium_convergence_06870","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PIGA and DPM2 each interact with more than one shared protein. One such shared protein is PIG-P, a 134-amino acid protein with two hydrophobic domains that a... | |
medium_convergence_06871 | STX2 and STX1A each interact with more than one shared gene product. Evidence concerning one of these shared entities reports: 'Both in vitro and in vivo binding studies showed that endobrevin binds to syntaxin 1.' Which cell type is enriched in that specific shared entity? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_06871","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STX2 and STX1A each interact with more than one shared gene product. Evidence concerning one of these shared entities reports: 'Both in vitro and in vivo bin... | |
medium_convergence_06872 | EP300 and MAPK8 share multiple interacting partners. One such partner is described in evidence stating: 'Following mitogen stimulation, S6Ks interact with the p300 and p300/CBP-associated factor (PCAF) acetyltransferases.' Which gene is connected to this specific shared partner through a 'binds' relationship? | TERT | Medium | convergence | {"qa_id":"medium_convergence_06872","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and MAPK8 share multiple interacting partners. One such partner is described in evidence stating: 'Following mitogen stimulation, S6Ks interact with th... | |
medium_convergence_06873 | GTF2H4 and CUL4A both interact with a specific protein. Experimental evidence indicates that in C17.2 cells subjected to oxygen-glucose deprivation/reoxygenation (OGD/R), simulated phosphorylation of KAP1 at serine 824 enhances the binding between p-KAP1 and this protein, while simultaneously decreasing the interaction... | DNA sliding clamp PCNA | Medium | convergence | {"qa_id":"medium_convergence_06873","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2H4 and CUL4A both interact with a specific protein. Experimental evidence indicates that in C17.2 cells subjected to oxygen-glucose deprivation/reoxygena... | |
medium_convergence_06874 | RNF20 and HIST1H2BO share binding partners. One such shared partner interacts with the RNF20/RNF40 complex through its C-terminal coiled-coil region and promotes the complex's E3 ligase activity for H2B ubiquitination. Which protein is encoded by this shared partner? | WW domain-containing adapter protein with coiled-coil | Medium | convergence | {"qa_id":"medium_convergence_06874","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RNF20 and HIST1H2BO share binding partners. One such shared partner interacts with the RNF20/RNF40 complex through its C-terminal coiled-coil region and prom... | |
medium_convergence_06875 | FANCD2 and FANCE both interact with a specific protein. Evidence regarding this protein states: 'In normal cells, HA-tagged FANCE protein coimmunoprecipitates with FANCA, FANCC, and [this protein] but not with FANCD2.' Which disease is associated with this protein through genomic alterations? | ovarian neoplasm | Medium | convergence | {"qa_id":"medium_convergence_06875","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCD2 and FANCE both interact with a specific protein. Evidence regarding this protein states: 'In normal cells, HA-tagged FANCE protein coimmunoprecipitate... | |
medium_convergence_06876 | EPAS1 and HIF1A share multiple interacting partners. One such shared partner is described in evidence stating that it and HIF-1alpha are able to associate in vivo but not in vitro, suggesting that this interaction involves the participation of additional proteins and/or a posttranslational modification of these factors... | Transcription factor Jun | Medium | convergence | {"qa_id":"medium_convergence_06876","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPAS1 and HIF1A share multiple interacting partners. One such shared partner is described in evidence stating that it and HIF-1alpha are able to associate in... | |
medium_convergence_06877 | Both Human alphaherpesvirus 1 and Zika virus are known to upregulate a specific gene. Experimental data for this gene, derived from a monocytic leukemia cell line (study GSE114966), reports a log2 fold change of approximately 1.005 and an adjusted p-value of 0.002812. Which disease is associated with this gene? | thymoma | Medium | convergence | {"qa_id":"medium_convergence_06877","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Zika virus are known to upregulate a specific gene. Experimental data for this gene, derived from a monocytic leukemia cell... | |
medium_convergence_06879 | NFIB and SKP1 share interaction partners. One such shared partner is involved in a noncanonical polycomb repressive complex 1 (PRC1) that includes RING1B, PCGF1, and BCOR, and whose recruitment by a specific F-box protein requires the F-box and leucine-rich repeat domains but not the JmjC demethylase domain. Which prot... | Lysine-specific demethylase 2B | Medium | convergence | {"qa_id":"medium_convergence_06879","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NFIB and SKP1 share interaction partners. One such shared partner is involved in a noncanonical polycomb repressive complex 1 (PRC1) that includes RING1B, PC... | |
medium_convergence_06880 | Diethylstilbestrol and Morphine share interactions with multiple drugs. One such shared drug is implicated in evidence stating: 'The concomitant administration of VPA and morphine caused an increase in social interaction criteria in both the chronic and withdrawal phases.' Which disease is this shared drug indicated fo... | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_06880","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Diethylstilbestrol and Morphine share interactions with multiple drugs. One such shared drug is implicated in evidence stating: 'The concomitant administrati... | |
medium_convergence_06881 | FGG and IL1R1 share multiple binding partners. One of these shared partners is reported to coimmunoprecipitate with the IL-1R signaling complex in an IL-1-dependent manner. Which cell type is this specific partner enriched in? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_06881","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FGG and IL1R1 share multiple binding partners. One of these shared partners is reported to coimmunoprecipitate with the IL-1R signaling complex in an IL-1-de... | |
medium_convergence_06882 | CENPS and HIST1H4A share multiple binding partners. One of these shared partners is described as binding at a stoichiometric ratio to the CENP-A/H4 tetramer but not to the H3/H4 tetramer. Which disease is associated with this specific shared partner? | astrocytoma (excluding glioblastoma) | Medium | convergence | {"qa_id":"medium_convergence_06882","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPS and HIST1H4A share multiple binding partners. One of these shared partners is described as binding at a stoichiometric ratio to the CENP-A/H4 tetramer ... | |
medium_convergence_06883 | ABI2 and ABL1 share common interaction partners. One such partner is characterized by evidence stating: 'The results show that the c-Abl SH3 domain binds directly to a proline-rich site (amino acids 567-576) in the C-terminal region of the protein encoded by this partner gene.' Which protein is encoded by the gene corr... | Tyrosine-protein kinase ABL2 | Medium | convergence | {"qa_id":"medium_convergence_06883","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ABI2 and ABL1 share common interaction partners. One such partner is characterized by evidence stating: 'The results show that the c-Abl SH3 domain binds dir... | |
medium_convergence_06884 | COPA and ANK3 both interact with a shared protein partner. Evidence regarding this partner states: 'Using a photocrosslinking approach, we find that under native conditions a peptide analogous to the cytoplasmic domain of p23 interacts with coatomer exclusively through its gamma subunit and shares its binding site with... | Coatomer subunit gamma-1 | Medium | convergence | {"qa_id":"medium_convergence_06884","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPA and ANK3 both interact with a shared protein partner. Evidence regarding this partner states: 'Using a photocrosslinking approach, we find that under na... |
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