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medium_convergence_06663 | TRIM28 and IGF2BP3 share a common interacting partner. Evidence indicates that the interaction between KAP-1 and this shared partner was verified by co-immunoprecipitation (Co-IP). Which disease is associated with this shared partner? | melanoma | Medium | convergence | {"qa_id":"medium_convergence_06663","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and IGF2BP3 share a common interacting partner. Evidence indicates that the interaction between KAP-1 and this shared partner was verified by co-immun... | |
medium_convergence_06664 | CREBBP and PYGO1 share multiple binding partners. One of these shared partners was identified via cloning based on its ability to bind CBP. Which protein is encoded by this specific shared partner? | Chromatin remodeling protein SRCAP | Medium | convergence | {"qa_id":"medium_convergence_06664","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and PYGO1 share multiple binding partners. One of these shared partners was identified via cloning based on its ability to bind CBP. Which protein is ... | |
medium_convergence_06665 | MYH3 and TNNC1 both interact with a specific protein partner. Experimental evidence regarding this partner states: 'On addition of troponin C to each of the CNBr-cleavage peptides in turn, perturbations of side chains were noted only for peptides CN5 (residues 1-21) and CN4 (residues 96-116).' Which protein is encoded ... | Troponin I, fast skeletal muscle | Medium | convergence | {"qa_id":"medium_convergence_06665","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYH3 and TNNC1 both interact with a specific protein partner. Experimental evidence regarding this partner states: 'On addition of troponin C to each of the ... | |
medium_convergence_06666 | Cyclosporine and Cimetidine both interact with a specific drug. Evidence indicates that Cimetidine inhibited the transport of [14C]thiamine, [14C]of this specific drug, and [14C]tetraethylammonium. Which disease is this drug indicated for? | congestive heart failure | Medium | convergence | {"qa_id":"medium_convergence_06666","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cyclosporine and Cimetidine both interact with a specific drug. Evidence indicates that Cimetidine inhibited the transport of [14C]thiamine, [14C]of this spe... | |
medium_convergence_06667 | GTF3C1 and GTF3C2 both interact with a shared protein partner. Evidence regarding this partner describes novel interactions of hTFIIIC63 with hTFIIIC102, hTFIIIB90, and hRPC62, as well as hTFIIIC102-hTFIIIB90 and hTFIIIB90-hRPC39 interactions that parallel those in yeast. Which protein is encoded by this shared partner... | General transcription factor 3C polypeptide 3 | Medium | convergence | {"qa_id":"medium_convergence_06667","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF3C1 and GTF3C2 both interact with a shared protein partner. Evidence regarding this partner describes novel interactions of hTFIIIC63 with hTFIIIC102, hTF... | |
medium_convergence_06668 | Rhinovirus A and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (study GSE106475) shows a log2 fold change of approximately -1.29 and an adjusted p-value of 0.0063. Which cellular component is this gene located in? | membrane | Medium | convergence | {"qa_id":"medium_convergence_06668","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (study GSE106475) shows a log... | |
medium_convergence_06669 | KCTD7 and PRKN (PARK2) both interact with a specific calpain gene. Evidence indicates that the protein product of this gene undergoes atypical, non-degradative ubiquitination at lysine residue K398, mediated by a complex involving KCTD7, Cullin-3, and Rbx1. Which protein is encoded by this gene? | Calpain-1 catalytic subunit | Medium | convergence | {"qa_id":"medium_convergence_06669","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCTD7 and PRKN (PARK2) both interact with a specific calpain gene. Evidence indicates that the protein product of this gene undergoes atypical, non-degradati... | |
medium_convergence_06670 | Human betaherpesvirus 5 and Dengue virus both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE111036) show a log2 fold change of -1.909 and an adjusted p-value of 0.04782. Which disease is associated with this gene through genomic alterations? | arthrogryposis, renal dysfunction, and cholestasis 1 | Medium | convergence | {"qa_id":"medium_convergence_06670","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Dengue virus both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (from study GSE... | |
medium_convergence_06671 | YWHAQ and NEDD4L both interact with a shared protein. Evidence indicates that NEDD4L recognizes the PY motif of this shared protein, interacts with it, and promotes its polyubiquitination. Which cell type is this shared protein enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_06671","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and NEDD4L both interact with a shared protein. Evidence indicates that NEDD4L recognizes the PY motif of this shared protein, interacts with it, and p... | |
medium_convergence_06672 | Both Orthohepevirus A and Zika virus are known to downregulate a specific gene. Experimental data for this gene in a study (GSE135619) reports a log2 fold change of approximately -1.296 and an adjusted p-value of 0.04032. Which cell type is this gene enriched in? | naive B cell | Medium | convergence | {"qa_id":"medium_convergence_06672","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Zika virus are known to downregulate a specific gene. Experimental data for this gene in a study (GSE135619) reports a log2 fold ch... | |
medium_convergence_06673 | YWHAQ and LRRK2 share common interacting partners. One such shared partner is supported by evidence stating: 'Moreover, we also showed that LRRK2 and this protein are interacting in eukaryotic cells.' Which protein is encoded by this specific shared interacting partner? | Serine/threonine-protein kinase MARK1 | Medium | convergence | {"qa_id":"medium_convergence_06673","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and LRRK2 share common interacting partners. One such shared partner is supported by evidence stating: 'Moreover, we also showed that LRRK2 and this pr... | |
medium_convergence_06674 | EP300 and HNRNPU each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'We found that this protein interacts with p300, and this interaction leads to suppression of p300-mediated acetylation of p53.' Which protein is encoded by the gene corresponding to that entity? | ATP-dependent RNA helicase DDX24 | Medium | convergence | {"qa_id":"medium_convergence_06674","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and HNRNPU each interact with more than one shared protein. Evidence concerning one of these shared entities states: 'We found that this protein intera... | |
medium_convergence_06676 | PPP2CA and PPP2R1A share multiple interacting partners. One such partner is described by evidence stating that IEX-1 binds to B56 subunits and pERK independently, enhances B56 phosphorylation by ERK at a conserved Ser/Pro site within this complex, and triggers dissociation from the catalytic subunit. Which protein corr... | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform | Medium | convergence | {"qa_id":"medium_convergence_06676","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP2CA and PPP2R1A share multiple interacting partners. One such partner is described by evidence stating that IEX-1 binds to B56 subunits and pERK independe... | |
medium_convergence_06677 | CHMP4B and CHMP6 both interact with a specific protein. Experimental evidence indicates that in a yeast two-hybrid assay, HD-PTP showed positive interactions with this protein (also known as Shax1), endophilin A1, and ALG-2, but not with RabGAPLP or CIN85. Which disease is associated with this protein through genomic a... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_06677","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP4B and CHMP6 both interact with a specific protein. Experimental evidence indicates that in a yeast two-hybrid assay, HD-PTP showed positive interactions... | |
medium_convergence_06678 | KAT5 and RAD51 both interact with a shared protein partner. Evidence regarding one such partner states: 'Using the yeast two-hybrid system, we isolated a cDNA encoding a novel human protein, named [a RAD51-interacting protein], that strongly interacts with human Rad51 recombinase.' Which disease is associated with this... | mammary neoplasms, animal | Medium | convergence | {"qa_id":"medium_convergence_06678","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and RAD51 both interact with a shared protein partner. Evidence regarding one such partner states: 'Using the yeast two-hybrid system, we isolated a cDN... | |
medium_convergence_06679 | DNM2 and BTC share multiple binding partners. One of these shared partners is associated with evidence stating: 'These observations therefore indicate that this protein interacts with dynamin and regulates endocytosis by forming vesicotubular structures.' Which protein is encoded by the gene corresponding to this share... | Formin-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06679","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNM2 and BTC share multiple binding partners. One of these shared partners is associated with evidence stating: 'These observations therefore indicate that t... | |
medium_convergence_06680 | PIAS3 and CEBPD both interact with a shared protein. Evidence indicates that this shared protein interacts with Smad proteins, most strongly with itself. Which protein is encoded by this shared entity? | SMAD family member 3 | Medium | convergence | {"qa_id":"medium_convergence_06680","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PIAS3 and CEBPD both interact with a shared protein. Evidence indicates that this shared protein interacts with Smad proteins, most strongly with itself. Whi... | |
medium_convergence_06681 | ERBB4 and GABRA1 share a common binding partner. Evidence regarding this shared entity states: 'Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and the ErbB4-receptor tyrosine kinases.' Which disease is associated with this shared entity? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06681","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB4 and GABRA1 share a common binding partner. Evidence regarding this shared entity states: 'Like NRG-1, the EGF-like domain of the new ligands binds to b... | |
medium_convergence_06682 | PARP1 and ESR1 share multiple interacting partners. One specific shared partner is identified by evidence reporting an interphase-specific interaction between condensin I and the DNA nick-sensor poly(ADP-ribose) polymerase 1 (PARP-1). Which disease is associated with this specific shared partner? | microcephaly 21, primary, autosomal recessive | Medium | convergence | {"qa_id":"medium_convergence_06682","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and ESR1 share multiple interacting partners. One specific shared partner is identified by evidence reporting an interphase-specific interaction betwee... | |
medium_convergence_06683 | IL10 and XBP1 are both involved in more than one shared biological process. One such shared process is linked to an entity characterized by the following observation: 'However, they secreted very little immunoglobulin of any isotype and failed to control infection with the B-cell-dependent polyoma virus, because plasma... | immunoglobulin production | Medium | convergence | {"qa_id":"medium_convergence_06683","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL10 and XBP1 are both involved in more than one shared biological process. One such shared process is linked to an entity characterized by the following obs... | |
medium_convergence_06684 | Both Vaccinia virus and Enterovirus A are known to downregulate a specific host gene. Experimental data from a study on cervical adenocarcinoma cell lines (GSE11238) indicates that this gene exhibits a log2 fold change of approximately -1.022 and an adjusted p-value of 2.031e-05. Which biological process is this gene i... | RNA processing | Medium | convergence | {"qa_id":"medium_convergence_06684","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Enterovirus A are known to downregulate a specific host gene. Experimental data from a study on cervical adenocarcinoma cell lines (G... | |
medium_convergence_06685 | HSPA8 and HSP90AA1 both interact with a shared gene product. Evidence regarding this shared entity states: 'Both domains are able to bind to the ATPase domain of HSC70 and inhibit rhodanese aggregation.' Which disease is associated with this entity via a biomarker relationship? | cryptorchidism | Medium | convergence | {"qa_id":"medium_convergence_06685","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA8 and HSP90AA1 both interact with a shared gene product. Evidence regarding this shared entity states: 'Both domains are able to bind to the ATPase domai... | |
medium_convergence_06686 | CHEK1 and CHEK2 share a common interacting partner. Evidence indicates that this specific partner binds to Chk1 and dephosphorylates the ATR-targeted phospho-Ser 345 residue, resulting in decreased Chk1 kinase activity. Which disease is associated with this entity via genomic alterations? | diffuse intrinsic pontine glioma | Medium | convergence | {"qa_id":"medium_convergence_06686","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and CHEK2 share a common interacting partner. Evidence indicates that this specific partner binds to Chk1 and dephosphorylates the ATR-targeted phospho... | |
medium_convergence_06687 | The biological processes 'regulation of ketone biosynthetic process' and 'regulation of aldosterone metabolic process' share a common parent process. Evidence regarding this shared parent process states: 'Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the fo... | ketone metabolic process | Medium | convergence | {"qa_id":"medium_convergence_06687","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'regulation of ketone biosynthetic process' and 'regulation of aldosterone metabolic process' share a common parent process. Evidenc... | |
medium_convergence_06688 | BIRC2 and RIPK1 both interact with a shared protein. Evidence indicates that this protein directly binds to cIAP1 via its seventh zinc finger, leading to the dissociation of the TRAF2/TRAF3 interaction and the subsequent inactivation of the ligase complex to stabilize NIK. Which cell type is this protein enriched in? | mucosal-associated invariant T cell | Medium | convergence | {"qa_id":"medium_convergence_06688","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and RIPK1 both interact with a shared protein. Evidence indicates that this protein directly binds to cIAP1 via its seventh zinc finger, leading to the... | |
medium_convergence_06689 | Amikacin and Kanamycin both interact with a specific shared drug. Clinical evidence regarding this shared drug indicates that mortality was significantly associated with relapse or the progression of the underlying malignancy, as well as resistance to both drugs in the combinations of this drug with amikacin or meropen... | Picosulfuric acid | Medium | convergence | {"qa_id":"medium_convergence_06689","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Amikacin and Kanamycin both interact with a specific shared drug. Clinical evidence regarding this shared drug indicates that mortality was significantly ass... | |
medium_convergence_06690 | FANCG and FANCM both interact with a specific protein that links Fanconi anemia proteins to the Notch1 developmental pathway via a direct protein-protein interaction with the FA core complex. This protein is identified as hairy enhancer of split 1. Which protein product is encoded by this gene? | Transcription factor HES-1 | Medium | convergence | {"qa_id":"medium_convergence_06690","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCG and FANCM both interact with a specific protein that links Fanconi anemia proteins to the Notch1 developmental pathway via a direct protein-protein int... | |
medium_convergence_06691 | CDKN1B and RB1 both interact with a shared gene product. Experimental evidence indicates that in BL40 cells, the majority of p27kip1 is complexed with this shared gene product, suggesting that overexpressed levels of this product contribute to the sequestering activity that inhibits p27kip1. Which disease is associated... | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06691","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN1B and RB1 both interact with a shared gene product. Experimental evidence indicates that in BL40 cells, the majority of p27kip1 is complexed with this s... | |
medium_convergence_06692 | TAB3 and TBK1 both interact with a shared protein. Contextual evidence indicates that this shared protein is associated with the N-terminal region of a TIR domain-containing adapter molecule and is involved in the pathway where TBK1 acts as a kinase for IFN regulatory factor-3, an essential transcription factor for IFN... | TIR domain-containing adapter molecule 1 | Medium | convergence | {"qa_id":"medium_convergence_06692","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TAB3 and TBK1 both interact with a shared protein. Contextual evidence indicates that this shared protein is associated with the N-terminal region of a TIR d... | |
medium_convergence_06693 | GNA13 and GNA15 both interact with a specific receptor protein. Experimental evidence indicates that purification of this receptor using the ligand SQ31,491 resulted in the co-purification of a member of the G12 family of G proteins. Which protein is encoded by the gene corresponding to this receptor? | Thromboxane A2 receptor | Medium | convergence | {"qa_id":"medium_convergence_06693","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNA13 and GNA15 both interact with a specific receptor protein. Experimental evidence indicates that purification of this receptor using the ligand SQ31,491 ... | |
medium_convergence_06694 | HIC1 and NFATC1 share interaction partners. One such shared partner is identified in a study revealing over 170 NFAT-associated proteins, many of which are transcriptional regulators. The study lists specific interaction partners of NFATc1 and NFATc2 in T cells, including Raptor, CHEK1, CREB1, the shared entity, SATB1,... | basophil | Medium | convergence | {"qa_id":"medium_convergence_06694","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIC1 and NFATC1 share interaction partners. One such shared partner is identified in a study revealing over 170 NFAT-associated proteins, many of which are t... | |
medium_convergence_06695 | FOXM1 and SQSTM1 share a common interacting partner. Evidence indicates that this partner directly interacts with FOXM1 via its N-terminal inhibitory domain, an interaction that disrupts the binding of cadherin-1 to FOXM1 and thereby protects FOXM1 from proteasomal degradation. Which protein is encoded by this shared i... | Protein LYRIC | Medium | convergence | {"qa_id":"medium_convergence_06695","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FOXM1 and SQSTM1 share a common interacting partner. Evidence indicates that this partner directly interacts with FOXM1 via its N-terminal inhibitory domain,... | |
medium_convergence_06696 | HYOU1 and EGFR share common interacting partners. One such partner is described in evidence stating: 'We demonstrate that Grp170 binds to this protein, an adapter of the transmembrane Hrd1 E3 ubiquitin ligase postulated to be the retrotranslocon, and links this interaction to Grp170's function during ERAD.' Which prote... | Protein sel-1 homolog 1 | Medium | convergence | {"qa_id":"medium_convergence_06696","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HYOU1 and EGFR share common interacting partners. One such partner is described in evidence stating: 'We demonstrate that Grp170 binds to this protein, an ad... | |
medium_convergence_06697 | CTNND1 and EGFR share interaction partners. One such partner is described in evidence stating that GST-fusion proteins containing the catalytic domain of a specific receptor-type tyrosine-protein phosphatase with a substrate-trapping D/A mutation were found to interact with p120(ctn), a component of adherens junctions.... | Receptor-type tyrosine-protein phosphatase eta | Medium | convergence | {"qa_id":"medium_convergence_06697","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNND1 and EGFR share interaction partners. One such partner is described in evidence stating that GST-fusion proteins containing the catalytic domain of a s... | |
medium_convergence_06698 | Human alphaherpesvirus 1 and Primate bocaparvovirus 1 are both reported to downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of approximately -1.26 and an adjusted p-value of approximately 0.0032. Which protein does this gene produ... | PPP1R9B | Medium | convergence | {"qa_id":"medium_convergence_06698","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Primate bocaparvovirus 1 are both reported to downregulate a specific gene. Experimental data for this gene in a monocytic leuke... | |
medium_convergence_06699 | DAXX and MYC both interact with a shared protein partner. Evidence regarding one such partner states: 'As example, the [Partner]-MYC interaction suggests a new mechanism for [Partner]/BRD4 chromatin complex regulation of MYC-driven tumours.' Which protein is encoded by the gene corresponding to this partner? | Histone-lysine N-methyltransferase NSD3 | Medium | convergence | {"qa_id":"medium_convergence_06699","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAXX and MYC both interact with a shared protein partner. Evidence regarding one such partner states: 'As example, the [Partner]-MYC interaction suggests a n... | |
medium_convergence_06700 | DNMT3A and GFI1 both interact with a shared protein partner. Evidence indicates that for one such partner, Gfi-1 does not directly bind to CDKN2B but instead interacts with Miz-1 and is recruited to the CDKN2B core promoter via Miz-1. Which disease is associated with this specific shared partner through genomic alterat... | lymphoma | Medium | convergence | {"qa_id":"medium_convergence_06700","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNMT3A and GFI1 both interact with a shared protein partner. Evidence indicates that for one such partner, Gfi-1 does not directly bind to CDKN2B but instead... | |
medium_convergence_06701 | DLG3 and BEGAIN both interact with a specific gene product. Evidence regarding this shared partner states: 'We quantitatively defined the contributions of carboxyl-terminal residues to binding selectivity of the prototypic interactions of the PDZ domains of postsynaptic density protein 95 (PSD-95) and its homolog synap... | Glutamate receptor ionotropic, NMDA 2B | Medium | convergence | {"qa_id":"medium_convergence_06701","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG3 and BEGAIN both interact with a specific gene product. Evidence regarding this shared partner states: 'We quantitatively defined the contributions of ca... | |
medium_convergence_06702 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. Experimental data from a melanoma cell line (study GSE136586) indicates that this gene has a log2 fold change of -1.386 and an adjusted p-value of 1.824e-07. Which protein is encoded by ... | CCAAT/enhancer-binding protein alpha | Medium | convergence | {"qa_id":"medium_convergence_06702","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. Experimental data from ... | |
medium_convergence_06704 | EGFR and NEDD4L share interaction partners. One such shared partner is described in mechanistic studies as the 14-3-3σ-interacting protein neural precursor cell-expressed developmentally down-regulated 4-like (NEDD4L), which functions as an E3 ligase targeting HIF-1α. Which protein is encoded by the gene corresponding ... | 14-3-3 protein sigma | Medium | convergence | {"qa_id":"medium_convergence_06704","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and NEDD4L share interaction partners. One such shared partner is described in mechanistic studies as the 14-3-3σ-interacting protein neural precursor c... | |
medium_convergence_06705 | Both 'regulation of monocyte chemotaxis' and 'regulation of dendritic cell chemotaxis' are subtypes of a shared biological process. Evidence regarding this shared process states: 'Any process that modulates the frequency, rate, or extent of monocyte chemotaxis.' Which biological process is directly regulated by this sh... | mononuclear cell migration | Medium | convergence | {"qa_id":"medium_convergence_06705","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both 'regulation of monocyte chemotaxis' and 'regulation of dendritic cell chemotaxis' are subtypes of a shared biological process. Evidence regarding this s... | |
medium_convergence_06707 | UHRF2 and BRD4 share common interaction partners. One such shared partner is involved in a direct protein-protein interaction with UHRF2 and also with FANCD2. Which protein is encoded by this shared interaction partner? | E3 ubiquitin-protein ligase UHRF1 | Medium | convergence | {"qa_id":"medium_convergence_06707","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UHRF2 and BRD4 share common interaction partners. One such shared partner is involved in a direct protein-protein interaction with UHRF2 and also with FANCD2... | |
medium_convergence_06708 | Both West Nile virus and Zaire ebolavirus are known to upregulate the expression of a specific gene. In a study involving monocyte-derived dendritic cells (GSE136342), one such shared target gene exhibited a log2 fold change of approximately 1.205 and an adjusted p-value of 0.01096. Which protein is encoded by this spe... | Tumor necrosis factor-inducible gene 6 protein | Medium | convergence | {"qa_id":"medium_convergence_06708","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Zaire ebolavirus are known to upregulate the expression of a specific gene. In a study involving monocyte-derived dendritic cells (G... | |
medium_convergence_06709 | GRB2 and ITGB1 share multiple binding partners. One shared partner is described as the adaptor for the Ras guanyl-nucleotide exchanger SOS, which binds to Tyr1356 in the YVNV motif. Which protein is encoded by this shared partner? | Hepatocyte growth factor receptor | Medium | convergence | {"qa_id":"medium_convergence_06709","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and ITGB1 share multiple binding partners. One shared partner is described as the adaptor for the Ras guanyl-nucleotide exchanger SOS, which binds to Ty... | |
medium_convergence_06710 | Both Influenza A virus and Orthohepevirus A are known to upregulate a specific gene. Experimental data from a non-small cell lung adenocarcinoma cell line (study GSE147507) indicates that this gene exhibits a log2 fold change of approximately 1.229 and an adjusted p-value of 2.424e-10. Which protein does this gene prod... | MTMR7 | Medium | convergence | {"qa_id":"medium_convergence_06710","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Orthohepevirus A are known to upregulate a specific gene. Experimental data from a non-small cell lung adenocarcinoma cell line (s... | |
medium_convergence_06711 | DNAJB6 and HSPA8 both interact with a shared protein partner. Experimental evidence indicates that this partner binds to the ATPase domain of Hsp70 and Hsc70 without requiring their carboxy-terminal peptide-binding domains, and it can be co-immunoprecipitated with Hsp/Hsc70 from cell lysates. Which protein is encoded b... | BAG family molecular chaperone regulator 1 | Medium | convergence | {"qa_id":"medium_convergence_06711","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNAJB6 and HSPA8 both interact with a shared protein partner. Experimental evidence indicates that this partner binds to the ATPase domain of Hsp70 and Hsc70... | |
medium_convergence_06712 | IRF7 and IKBKE each interact with more than one shared protein. Evidence concerning one shared entity reports that a specific molecule was isolated as interacting specifically with inducible IkappaB kinase (IKK-i) by the yeast two-hybrid screening procedure. Which protein is connected to that entity through the 'encode... | TRAF family member-associated NF-kappa-B activator | Medium | convergence | {"qa_id":"medium_convergence_06712","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IRF7 and IKBKE each interact with more than one shared protein. Evidence concerning one shared entity reports that a specific molecule was isolated as intera... | |
medium_convergence_06713 | ITK and GRAP2 both interact with a shared protein. Evidence indicates that this shared protein and ITK were observed to co-associate in response to CD3 cross-linking in Jurkat T cells, but not in P116 T cells. Which protein is encoded by the gene corresponding to this shared entity? | Linker for activation of T-cells family member 1 | Medium | convergence | {"qa_id":"medium_convergence_06713","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ITK and GRAP2 both interact with a shared protein. Evidence indicates that this shared protein and ITK were observed to co-associate in response to CD3 cross... | |
medium_convergence_06715 | HDAC1 and HNF4A both interact with a specific shared protein. Evidence regarding this shared entity states: 'Remarkably, AF-1 interacted specifically with multiple transcriptional targets, including the TATA-binding protein; the TATA-binding protein-associated factors TAFII31 and TAFII80; transcription factor IIB; tran... | Transcriptional adapter 2-alpha | Medium | convergence | {"qa_id":"medium_convergence_06715","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and HNF4A both interact with a specific shared protein. Evidence regarding this shared entity states: 'Remarkably, AF-1 interacted specifically with mu... | |
medium_convergence_06717 | H3-3A and HDAC3 share a common interaction partner. Evidence regarding this shared entity states: 'Deletion analysis of the shared entity revealed that HDAC3 binds multiple regions of the shared entity in vitro and that all of these regions are required for maximal binding in vivo.' Which protein is encoded by this sha... | Nuclear receptor corepressor 1 | Medium | convergence | {"qa_id":"medium_convergence_06717","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H3-3A and HDAC3 share a common interaction partner. Evidence regarding this shared entity states: 'Deletion analysis of the shared entity revealed that HDAC3... | |
medium_convergence_06718 | HIST2H3C and PARP1 share common interacting partners. One such partner forms complexes with H3.2 that, when purified, show enrichment for trimethyl-K27, dimethyl-K4, and acetyl-K9 histone modifications. Which disease is associated with this specific interacting partner via a biomarker relationship? | leukemia | Medium | convergence | {"qa_id":"medium_convergence_06718","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIST2H3C and PARP1 share common interacting partners. One such partner forms complexes with H3.2 that, when purified, show enrichment for trimethyl-K27, dime... | |
medium_convergence_06719 | EP300 and BCL9 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'A monoclonal antibody raised against the carboxyl terminus of this protein coimmunoprecipitates CBP/p300, supporting the model that this protein is a CBP binding protein and that these proteins can be found t... | Floating-Harbor syndrome | Medium | convergence | {"qa_id":"medium_convergence_06719","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and BCL9 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'A monoclonal antibody raised against the carb... | |
medium_convergence_06721 | XRCC6 and XRCC5 both interact with a specific shared gene product. Evidence regarding this shared entity states: 'We identified DNA-dependent protein kinase catalytic subunit (DNA-PKcs), Ku80, and Ku70 as the shared entity associated factors.' Which protein is encoded by this shared gene? | Bile acid receptor | Medium | convergence | {"qa_id":"medium_convergence_06721","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"XRCC6 and XRCC5 both interact with a specific shared gene product. Evidence regarding this shared entity states: 'We identified DNA-dependent protein kinase ... | |
medium_convergence_06722 | Enterovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene in a study (GSE103308) reports a log2 fold change of approximately 3.45 and an adjusted p-value of 0.000571. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06722","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene in a study (GSE103308) reports a log2 fold change of approximately 3.... | |
medium_convergence_06723 | PCNA and POLD4 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We show here that ectopic overexpression of the E3 ubiquitin ligase (a central regulator of TLS) induces DNA damage-independent mono-ubiquitination of proliferating cell nuclear antigen (PCNA) (a known substr... | E3 ubiquitin-protein ligase RAD18 | Medium | convergence | {"qa_id":"medium_convergence_06723","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PCNA and POLD4 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We show here that ectopic overexpression of t... | |
medium_convergence_06724 | DVL2 and SMAD3 share a common binding partner. Experimental evidence indicates that this shared partner interacts with receptor-activated Smads (R-Smads), specifically Smad1, Smad2, and the shared partner itself, but does not interact with Smad4. Which disease is associated with this shared binding partner? | lung adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_06724","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DVL2 and SMAD3 share a common binding partner. Experimental evidence indicates that this shared partner interacts with receptor-activated Smads (R-Smads), sp... | |
medium_convergence_06725 | Both Human gammaherpesvirus 4 and Measles morbillivirus are associated with the downregulation of a specific gene. Experimental data from a study on gamma delta T-lymphocytes (GSE13906) indicates that this gene exhibits a log2 fold change of approximately -1.478 and an adjusted p-value of 0.04589. Which protein is enco... | Zinc finger protein 608 | Medium | convergence | {"qa_id":"medium_convergence_06725","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human gammaherpesvirus 4 and Measles morbillivirus are associated with the downregulation of a specific gene. Experimental data from a study on gamma de... | |
medium_convergence_06726 | UBE2E3 and DDX5 both interact with a shared protein. Experimental evidence for this shared interaction includes the statement: 'We confirmed the interaction of seven hits with a specific RNA-binding protein by co-immunoprecipitation and assessed their co-localization in HEK293E cells.' Which protein is encoded by the g... | TAR DNA-binding protein 43 | Medium | convergence | {"qa_id":"medium_convergence_06726","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBE2E3 and DDX5 both interact with a shared protein. Experimental evidence for this shared interaction includes the statement: 'We confirmed the interaction ... | |
medium_convergence_06727 | KCNJ5 and KCNQ1 both enable a shared molecular function. Evidence indicates that the protein encoded by KCNQ1 (KVLQT1) is strongly expressed in the heart and possesses structural features of a voltage-gated potassium channel. Which biological process is this shared molecular function a part of? | membrane repolarization during ventricular cardiac muscle cell action potential | Medium | convergence | {"qa_id":"medium_convergence_06727","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNJ5 and KCNQ1 both enable a shared molecular function. Evidence indicates that the protein encoded by KCNQ1 (KVLQT1) is strongly expressed in the heart and... | |
medium_convergence_06728 | AP2S1 and AP2B1 both interact with a common protein partner. Experimental evidence indicates that this partner binds to beta2-Adaptin in yeast two-hybrid assays and co-immunoprecipitates with beta-arrestins and the beta-2 adrenergic receptor in an agonist-dependent manner in HEK-293 cells. Which disease is associated w... | leukemia | Medium | convergence | {"qa_id":"medium_convergence_06728","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP2S1 and AP2B1 both interact with a common protein partner. Experimental evidence indicates that this partner binds to beta2-Adaptin in yeast two-hybrid ass... | |
medium_convergence_06729 | Both Human respirovirus 3 and Cardiovirus A are associated with the upregulation of a specific gene. Experimental data from a non-small cell lung adenocarcinoma cell line (study GSE147507) indicates that this gene exhibits a log2 fold change of approximately 1.48 and an adjusted p-value of 0.0493. Which protein is enco... | Urokinase plasminogen activator surface receptor | Medium | convergence | {"qa_id":"medium_convergence_06729","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Cardiovirus A are associated with the upregulation of a specific gene. Experimental data from a non-small cell lung adenocarcin... | |
medium_convergence_06730 | CHUK and RNF31 both interact with a specific protein that is a component of the LUBAC complex, which is defined as containing this protein, HOIL-1L, and HOIP. Which protein is encoded by the gene corresponding to this LUBAC component? | Sharpin | Medium | convergence | {"qa_id":"medium_convergence_06730","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and RNF31 both interact with a specific protein that is a component of the LUBAC complex, which is defined as containing this protein, HOIL-1L, and HOIP... | |
medium_convergence_06731 | Both Human alphaherpesvirus 3 and Human immunodeficiency virus 1 are known to downregulate a specific shared host gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.054 and an adjusted p-value of 5.953e-05. In which cellular compo... | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_06731","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Human immunodeficiency virus 1 are known to downregulate a specific shared host gene. Experimental data from a melanoma cel... | |
medium_convergence_06732 | TRIM28 and MYC share common interaction partners. One such shared partner is described in evidence stating: 'We show that this protein interacts with TRIM28, a master regulator of gene expression, in the nucleus of NSCLC cells.' Which gene does this shared partner bind to? | YES1 | Medium | convergence | {"qa_id":"medium_convergence_06732","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and MYC share common interaction partners. One such shared partner is described in evidence stating: 'We show that this protein interacts with TRIM28,... | |
medium_convergence_06733 | Both Influenza A virus and Cardiovirus A are known to upregulate a specific gene. Experimental data for this gene, derived from a non-small cell lung adenocarcinoma cell line, reports a log2 fold change of approximately 1.148 and an adjusted p-value of 0.000375. Which protein does this gene product interact with? | RELB | Medium | convergence | {"qa_id":"medium_convergence_06733","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Cardiovirus A are known to upregulate a specific gene. Experimental data for this gene, derived from a non-small cell lung adenoca... | |
medium_convergence_06734 | Both Measles morbillivirus and Influenza A virus have been shown to downregulate the expression of a specific host gene. In a study (GSE131840), this gene exhibited a log2 fold change of approximately -1.062 and an adjusted p-value of 0.004681. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_06734","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus have been shown to downregulate the expression of a specific host gene. In a study (GSE131840), this gene ex... | |
medium_convergence_06735 | Both West Nile virus and Severe acute respiratory syndrome-related coronavirus upregulate a specific gene. Experimental data for this gene in monocyte-derived dendritic cells (study GSE136342) reports a log2 fold change of approximately 1.205 and an adjusted p-value of 0.01096. Which cellular component is this gene loc... | extracellular region | Medium | convergence | {"qa_id":"medium_convergence_06735","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both West Nile virus and Severe acute respiratory syndrome-related coronavirus upregulate a specific gene. Experimental data for this gene in monocyte-derive... | |
medium_convergence_06736 | EIF2B1 and EIF2B4 are both involved in multiple shared biological processes. One of these shared processes is supported by evidence stating: 'This eIF2B increased protein synthesis in the reconstituted in vitro human translation system.' Which biological process, connected to this entity via an 'is a' relationship, is ... | translational initiation | Medium | convergence | {"qa_id":"medium_convergence_06736","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF2B1 and EIF2B4 are both involved in multiple shared biological processes. One of these shared processes is supported by evidence stating: 'This eIF2B incr... | |
medium_convergence_06737 | YAP1 and TOPBP1 both interact with a shared protein. Evidence indicates that the in vivo interaction of endogenous TOPBP1 and this shared protein was demonstrated in HeLa-S3 cells via co-immunoprecipitation. Which protein is encoded by the gene corresponding to this shared entity? | Poly [ADP-ribose] polymerase 1 | Medium | convergence | {"qa_id":"medium_convergence_06737","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and TOPBP1 both interact with a shared protein. Evidence indicates that the in vivo interaction of endogenous TOPBP1 and this shared protein was demonst... | |
medium_convergence_06738 | CLEC16A and PRKN share common interacting partners. One such partner is described in evidence stating: 'We demonstrate that parkin interacts with and robustly ubiquitinates this protein in human neural cells.' Which cell type is this protein enriched in? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_06738","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLEC16A and PRKN share common interacting partners. One such partner is described in evidence stating: 'We demonstrate that parkin interacts with and robustl... | |
medium_convergence_06740 | The biological processes 'negative regulation of microtubule depolymerization' and 'negative regulation of microtubule polymerization' share a common parent process. Evidence regarding one of these shared entities states: 'Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolym... | microtubule polymerization or depolymerization | Medium | convergence | {"qa_id":"medium_convergence_06740","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'negative regulation of microtubule depolymerization' and 'negative regulation of microtubule polymerization' share a common parent ... | |
medium_convergence_06741 | CDK4 and CEBPA share a common interacting partner. Evidence regarding this shared partner states: 'Our previous studies showed that while both specific CDK4 inhibitor p16INK4A (P16) and gankyrin bind to cyclin-dependent kinase 4 (CDK4) in similar fashion, only P16 inhibits the kinase activity of CDK4.' Which disease is... | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06741","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK4 and CEBPA share a common interacting partner. Evidence regarding this shared partner states: 'Our previous studies showed that while both specific CDK4 ... | |
medium_convergence_06742 | HDAC2 and GATAD2A each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In glutathione S-transferase pull-down assays, this entity is found associated with several known components of the Mi2-NuRD complex, including HDAC1, HDAC2, MTA1, MBD3, p66, RbAp46, and RbAp48.' Which pro... | Methyl-CpG-binding domain protein 3-like 2 | Medium | convergence | {"qa_id":"medium_convergence_06742","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC2 and GATAD2A each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In glutathione S-transferase pull-down ass... | |
medium_convergence_06743 | GATAD2A and H3C1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We demonstrate direct binding of both p66 family members to this protein as well as MBD3.' Which protein is encoded by that shared entity? | Methyl-CpG-binding domain protein 2 | Medium | convergence | {"qa_id":"medium_convergence_06743","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GATAD2A and H3C1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We demonstrate direct binding ... | |
medium_convergence_06744 | PARP1 and EP300 share common interaction partners. One such shared partner has been shown to interact with PARP1 at the PARP-A-helical domain and to deacetylate the K249 residue of PARP1. Which protein encodes this specific shared interaction partner? | NAD-dependent protein deacetylase sirtuin-2 | Medium | convergence | {"qa_id":"medium_convergence_06744","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and EP300 share common interaction partners. One such shared partner has been shown to interact with PARP1 at the PARP-A-helical domain and to deacetyl... | |
medium_convergence_06745 | YWHAQ and CRK both interact with a shared protein. Evidence regarding this shared protein states: 'The nonreceptor tyrosine kinase binds to cytosolic 14-3-3 proteins and is targeted to the nucleus in the apoptotic response to DNA damage.' Which protein is encoded by the gene corresponding to this shared entity? | Tyrosine-protein kinase ABL1 | Medium | convergence | {"qa_id":"medium_convergence_06745","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and CRK both interact with a shared protein. Evidence regarding this shared protein states: 'The nonreceptor tyrosine kinase binds to cytosolic 14-3-3 ... | |
medium_convergence_06746 | DCAF7 and MYC both interact with a shared protein. Evidence regarding this shared protein states: 'We have isolated the cDNA encoding a novel c-Myc-binding protein, [REDACTED], by the yeast two-hybrid screening of a human HeLa cell cDNA library.' Which protein is encoded by this shared entity? | Prefoldin subunit 5 | Medium | convergence | {"qa_id":"medium_convergence_06746","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCAF7 and MYC both interact with a shared protein. Evidence regarding this shared protein states: 'We have isolated the cDNA encoding a novel c-Myc-binding p... | |
medium_convergence_06748 | MYC and PSMC4 share multiple interacting partners. One such shared partner is described in a study stating: 'In the present study, we show that this protein interacts with S6' ATPase, a subunit of the proteasomal 19 S regulatory complex.' Which protein is encoded by this shared interacting partner? | E3 ubiquitin-protein ligase RING2 | Medium | convergence | {"qa_id":"medium_convergence_06748","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and PSMC4 share multiple interacting partners. One such shared partner is described in a study stating: 'In the present study, we show that this protein ... | |
medium_convergence_06749 | CENPA and AHCTF1 both interact with a shared protein. Evidence regarding this shared entity states: 'Here, we show that CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of three new human centromere proteins (CENP-M, CENP-N and CENP-T), along with CENP-U(50), CENP-C an... | Centromere protein N | Medium | convergence | {"qa_id":"medium_convergence_06749","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and AHCTF1 both interact with a shared protein. Evidence regarding this shared entity states: 'Here, we show that CENP-A nucleosomes directly recruit a... | |
medium_convergence_06750 | Both IL4 and IL4R share binding partners. One such shared partner is a protein that is preferentially expressed in committed Th1 cells and interacts with the cytoplasmic region of the IL-4Ralpha chain irrespective of receptor tyrosine phosphorylation. Which protein is encoded by the gene corresponding to this shared pa... | Suppressor of cytokine signaling 5 | Medium | convergence | {"qa_id":"medium_convergence_06750","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IL4 and IL4R share binding partners. One such shared partner is a protein that is preferentially expressed in committed Th1 cells and interacts with the... | |
medium_convergence_06751 | BRMS1 and HDAC1 both interact with more than one shared gene. Evidence for one shared gene describes a cell cycle-regulated protein that binds the SIN3-HDAC complex. Which protein is encoded by the shared gene best supported by this evidence? | SIN3-HDAC complex-associated factor | Medium | convergence | {"qa_id":"medium_convergence_06751","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRMS1 and HDAC1 both interact with more than one shared gene. Evidence for one shared gene describes a cell cycle-regulated protein that binds the SIN3-HDAC ... | |
medium_convergence_06752 | RBPMS and PRKN share common interacting partners. One such shared partner is described in the following context: 'Here, we investigate the role of the endosomal adaptor [Entity] during the mitochondrial stress response and identify its interaction and colocalisation with the Parkinson's disease-associated E3 ubiquitin ... | asthma | Medium | convergence | {"qa_id":"medium_convergence_06752","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RBPMS and PRKN share common interacting partners. One such shared partner is described in the following context: 'Here, we investigate the role of the endoso... | |
medium_convergence_06753 | FBXW11 and PLK1 both interact with a specific shared protein. Evidence indicates that this shared protein is an interactor of the F-box protein beta-TrCP, as demonstrated by an unbiased screen. Which protein is encoded by this shared entity? | RE1-silencing transcription factor | Medium | convergence | {"qa_id":"medium_convergence_06753","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXW11 and PLK1 both interact with a specific shared protein. Evidence indicates that this shared protein is an interactor of the F-box protein beta-TrCP, as... | |
medium_convergence_06754 | ESR1 and AR both interact with a shared protein. Experimental evidence indicates that a specific domain within SV (amino acids 594-1268) interacts with the N-terminus and DNA-binding domain-ligand-binding domain of this shared protein in a ligand-enhanced manner, as demonstrated by mammalian two-hybrid and glutathione ... | Supervillin | Medium | convergence | {"qa_id":"medium_convergence_06754","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and AR both interact with a shared protein. Experimental evidence indicates that a specific domain within SV (amino acids 594-1268) interacts with the N... | |
medium_convergence_06755 | PSMA6 and PSMB2 both interact with a common protein partner. Evidence regarding this partner states: 'For example, the C-terminal extension of standard subunit beta2 is required for beta2's interaction with adjacent beta3, whereas the C-terminal extension of immunosubunit beta2i is dispensable for beta2i's interaction ... | Proteasome subunit beta type-3 | Medium | convergence | {"qa_id":"medium_convergence_06755","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMA6 and PSMB2 both interact with a common protein partner. Evidence regarding this partner states: 'For example, the C-terminal extension of standard subun... | |
medium_convergence_06756 | CDK8 and TOPBP1 both interact with a specific shared protein. Evidence indicates that a metazoa-specific replication factor, cyclin-dependent kinase 8/19-cyclin C, binds to a central domain of this shared protein. What protein is encoded by this shared entity? | Mdm2-binding protein | Medium | convergence | {"qa_id":"medium_convergence_06756","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK8 and TOPBP1 both interact with a specific shared protein. Evidence indicates that a metazoa-specific replication factor, cyclin-dependent kinase 8/19-cyc... | |
medium_convergence_06757 | SEC61B and LRRK2 both interact with a common gene product. Experimental evidence using protein-protein interaction arrays identified BCL2-associated athanogene 5, a member of the RAB7 family, and Cyclin-G-associated kinase as binding partners of this shared entity. Which protein is encoded by this gene? | Ras-related protein Rab-29 | Medium | convergence | {"qa_id":"medium_convergence_06757","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SEC61B and LRRK2 both interact with a common gene product. Experimental evidence using protein-protein interaction arrays identified BCL2-associated athanoge... | |
medium_convergence_06758 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of -1.471 and an adjusted p-value of 2.87e-07. Which protein is encoded by this gene? | Sorting nexin-30 | Medium | convergence | {"qa_id":"medium_convergence_06758","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. Experimental data for t... | |
medium_convergence_06759 | Both CYLD and EP300 interact with a specific shared protein. Evidence indicates that this shared protein interacts with the transcriptional coactivator p300, leading to the acetylation of the shared protein on two lysine residues in its N terminus. Which gene encodes this shared protein? | SMAD family member 7 | Medium | convergence | {"qa_id":"medium_convergence_06759","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both CYLD and EP300 interact with a specific shared protein. Evidence indicates that this shared protein interacts with the transcriptional coactivator p300,... | |
medium_convergence_06760 | KMT2A and PML share common interacting partners. One such partner is identified by evidence stating: 'Here we exploit fluorescence resonance energy transfer (FRET) to demonstrate that [this partner] physically interacts in vivo with the promyelocytic leukaemia (PML) protein within specific subnuclear compartments that ... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06760","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KMT2A and PML share common interacting partners. One such partner is identified by evidence stating: 'Here we exploit fluorescence resonance energy transfer ... | |
medium_convergence_06761 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.75 and an adjusted p-value of 0.01005. Which protein is encoded by this gene? | Pentraxin-related protein PTX3 | Medium | convergence | {"qa_id":"medium_convergence_06761","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (stud... | |
medium_convergence_06762 | PRKCI and CASP8 share multiple binding partners. One such shared partner is described in evidence stating: 'Caspase 8 can interact with multiple proteins known to be involved in the activation of the NF-kappaB pathway, including the serine-threonine kinases [a serine-threonine kinase], NIK, IKK1 and IKK2.' Which cell t... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06762","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKCI and CASP8 share multiple binding partners. One such shared partner is described in evidence stating: 'Caspase 8 can interact with multiple proteins kno... | |
medium_convergence_06763 | Insulin lispro and Cyclosporine share common drug-drug interactions. One of these shared interacting agents is reported to partially inhibit CF cytotoxicity. Which disease is this specific agent indicated for? | Familial type 3 hyperlipoproteinemia | Medium | convergence | {"qa_id":"medium_convergence_06763","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Insulin lispro and Cyclosporine share common drug-drug interactions. One of these shared interacting agents is reported to partially inhibit CF cytotoxicity.... | |
medium_convergence_06764 | Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of 3.955 and an adjusted p-value of 0.02705. Which protein is encoded by this gene? | Interferon lambda-1 | Medium | convergence | {"qa_id":"medium_convergence_06764","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zaire ebolavirus both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fo... | |
medium_convergence_06765 | Calcium ion homeostasis and potassium ion homeostasis share a common parent biological process. Evidence for one of these shared processes states: 'Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.' Which biological process is the parent of that entity? | chemical homeostasis | Medium | convergence | {"qa_id":"medium_convergence_06765","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Calcium ion homeostasis and potassium ion homeostasis share a common parent biological process. Evidence for one of these shared processes states: 'Any proce... | |
medium_convergence_06766 | PAXIP1 and H2AX both interact with a common protein partner. Evidence indicates that this partner exhibits increased association with hPTIP specifically in response to ionizing radiation, but not to other DNA-damaging agents. Which disease is linked to this protein partner through genomic alterations? | lupus vulgaris | Medium | convergence | {"qa_id":"medium_convergence_06766","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PAXIP1 and H2AX both interact with a common protein partner. Evidence indicates that this partner exhibits increased association with hPTIP specifically in r... | |
medium_convergence_06767 | Both Human alphaherpesvirus 1 and Influenza A virus downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of approximately -1.89 and an adjusted p-value of 0.0117. Which biological process is this gene involved in? | regulation of G protein-coupled receptor signaling pathway | Medium | convergence | {"qa_id":"medium_convergence_06767","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Influenza A virus downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GS... | |
medium_convergence_06768 | ALYREF and SRSF3 both interact with a shared protein component of the THO complex. Experimental evidence indicates that Aly directly interacts with THO subunits, specifically identifying this shared entity alongside Thoc5. Which protein product is encoded by this shared entity? | THO complex subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_06768","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALYREF and SRSF3 both interact with a shared protein component of the THO complex. Experimental evidence indicates that Aly directly interacts with THO subun... | |
medium_convergence_06769 | EGFR and RHOA share a common interacting partner. Evidence indicates that this partner coprecipitates with activated epidermal growth factor and platelet-derived growth factor (PDGF) receptors, and that phosphorylated tyrosine residues on the PDGF receptor mediate its tyrosine phosphorylation. Which disease is associat... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_06769","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and RHOA share a common interacting partner. Evidence indicates that this partner coprecipitates with activated epidermal growth factor and platelet-der... | |
medium_convergence_06770 | EP300 and IRF3 both interact with a shared protein partner. Experimental evidence indicates that a dominant-negative form of this partner (IRF-7 DN) binds to both IRF-3 and the partner itself, as detected by GST pull-down assays and immunoprecipitation in infected cells, despite having no effect on virus-stimulated nuc... | Interferon regulatory factor 7 | Medium | convergence | {"qa_id":"medium_convergence_06770","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and IRF3 both interact with a shared protein partner. Experimental evidence indicates that a dominant-negative form of this partner (IRF-7 DN) binds to... |
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