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medium_convergence_06885 | CNOT1 and CNOT11 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'We demonstrate that a specific RING-type E3 ligase is an active enzyme which stably associates with CCR4-NOT via NOT9 through a short linear motif (SLiM) embedded within the C-terminal low-complexity re... | ORC ubiquitin ligase 1 | Medium | convergence | {"qa_id":"medium_convergence_06885","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CNOT1 and CNOT11 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'We demonstrate that a specific RING-typ... | |
medium_convergence_06886 | PLK1 and STK4 share common interaction partners. One such shared partner is characterized by evidence stating that it responds to the HER2 signaling cascade by translocating into the nucleus following phosphorylation at Serine 273. This translocation allows it to contribute to cell mitosis regulation by binding with PL... | SHC SH2 domain-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06886","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PLK1 and STK4 share common interaction partners. One such shared partner is characterized by evidence stating that it responds to the HER2 signaling cascade ... | |
medium_convergence_06887 | CFL1 and GRK2 share common interaction partners. One such partner is described in evidence stating that beta-arrestins can interact with cofilin, LIMK, and chronophin and colocalize with them in membrane protrusions, suggesting that beta-arrestins may spatially regulate their activities. Which cell type is enriched for... | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_06887","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CFL1 and GRK2 share common interaction partners. One such partner is described in evidence stating that beta-arrestins can interact with cofilin, LIMK, and c... | |
medium_convergence_06888 | SMAD1 and ACVR2B both interact with a specific inhibitory Smad protein. Evidence indicates that this protein specifically competes with Smad4 for binding to receptor-activated Smad1, resulting in the formation of an apparently inactive Smad1-protein complex. Which gene encodes this inhibitory Smad protein? | SMAD family member 6 | Medium | convergence | {"qa_id":"medium_convergence_06888","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD1 and ACVR2B both interact with a specific inhibitory Smad protein. Evidence indicates that this protein specifically competes with Smad4 for binding to ... | |
medium_convergence_06889 | Dengue virus and Cardiovirus A both downregulate a specific gene. Experimental data from a hepatoma cell line (study GSE110512) indicates that this gene has a log2 fold change of -1.072 and an adjusted p-value of 0.03356. Which protein interacts with this gene product? | DYNLL1 | Medium | convergence | {"qa_id":"medium_convergence_06889","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Cardiovirus A both downregulate a specific gene. Experimental data from a hepatoma cell line (study GSE110512) indicates that this gene has ... | |
medium_convergence_06890 | TRIM28 and DDX17 both interact with a shared protein. Experimental evidence indicates that the interaction between KAP-1 (TRIM28) and this shared protein was verified by co-immunoprecipitation (Co-IP). Which protein is encoded by this shared entity? | Probable ATP-dependent RNA helicase DDX5 | Medium | convergence | {"qa_id":"medium_convergence_06890","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and DDX17 both interact with a shared protein. Experimental evidence indicates that the interaction between KAP-1 (TRIM28) and this shared protein was... | |
medium_convergence_06891 | ESR1 and SREBF1 both interact with a shared protein. Evidence regarding this shared protein states: 'Studies with extracts from TRAP220(-/-) fibroblasts reveal that these interactions depend on TRAP220, a TRAP/Mediator subunit previously shown to interact with ER and other nuclear receptors in a ligand-dependent manner... | Mediator of RNA polymerase II transcription subunit 12 | Medium | convergence | {"qa_id":"medium_convergence_06891","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and SREBF1 both interact with a shared protein. Evidence regarding this shared protein states: 'Studies with extracts from TRAP220(-/-) fibroblasts reve... | |
medium_convergence_06892 | EP300 and TBK1 share common interaction partners. One such shared partner is reported to interact with and phosphorylate both itself and Cdh1. Which protein is encoded by this shared partner? | Cell division cycle protein 20 homolog | Medium | convergence | {"qa_id":"medium_convergence_06892","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and TBK1 share common interaction partners. One such shared partner is reported to interact with and phosphorylate both itself and Cdh1. Which protein ... | |
medium_convergence_06893 | BRD1 and HSP90AA1 share multiple interacting partners. One such partner is characterized by evidence showing it associates with HSP90 and CRAF in cells via its N-terminal DOC domain, a domain that is mutationally disrupted in tumor cells with activated MAP kinase signaling. Which protein is encoded by this specific int... | E3 ubiquitin-protein ligase HECTD3 | Medium | convergence | {"qa_id":"medium_convergence_06893","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD1 and HSP90AA1 share multiple interacting partners. One such partner is characterized by evidence showing it associates with HSP90 and CRAF in cells via i... | |
medium_convergence_06894 | CBX5 and HDAC1 both interact with a specific protein. Evidence regarding this protein indicates that amino-acid substitutions in its PxVxL motif abolish interaction with members of the heterochromatin protein 1 (HP1) family and prevent its centromeric localization in differentiated cells. Which protein is encoded by th... | Transcription intermediary factor 1-beta | Medium | convergence | {"qa_id":"medium_convergence_06894","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX5 and HDAC1 both interact with a specific protein. Evidence regarding this protein indicates that amino-acid substitutions in its PxVxL motif abolish inte... | |
medium_convergence_06896 | BMI1 and L3MBTL2 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The RING domains of both proteins mediate their association and subsequent stabilization.' Which disease is associated with that specific shared protein partner? | Luo-Schoch-Yamamoto syndrome | Medium | convergence | {"qa_id":"medium_convergence_06896","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMI1 and L3MBTL2 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'The RING domains of both ... | |
medium_convergence_06897 | Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of -1.425 and an adjusted p-value of 0.02913. Which protein is encoded by this gene? | 2'-5'-oligoadenylate synthase 1 | Medium | convergence | {"qa_id":"medium_convergence_06897","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 ... | |
medium_convergence_06898 | TOPBP1 and E2F1 share common interacting partners. One such shared partner is activated by glucose deprivation, where it deacetylates TOPBP1, leading to the dissociation of the TOPBP1-Treslin complex and the inhibition of DNA replication. Which protein is encoded by this shared partner? | NAD-dependent protein deacetylase sirtuin-1 | Medium | convergence | {"qa_id":"medium_convergence_06898","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and E2F1 share common interacting partners. One such shared partner is activated by glucose deprivation, where it deacetylates TOPBP1, leading to the ... | |
medium_convergence_06899 | EHMT2 and KDM1A share multiple interacting partners. One such shared partner is described by the following evidence: 'Strikingly, we found that this protein binds to both SUV39H1 and G9A histone methyl transferases, which provides a direct link between histone methylation and this protein at heterochromatic and euchrom... | platelet-type bleeding disorder 17 | Medium | convergence | {"qa_id":"medium_convergence_06899","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and KDM1A share multiple interacting partners. One such shared partner is described by the following evidence: 'Strikingly, we found that this protein ... | |
medium_convergence_06900 | LILRB4 and FOXP3 are both involved in more than one shared biological process. Evidence indicates that T cells transduced with one of these entities exhibit impaired proliferation and reduced production of cytokines, including IL-2 and IL-10, upon TCR stimulation. Which biological process, connected to this entity via ... | T cell cytokine production | Medium | convergence | {"qa_id":"medium_convergence_06900","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LILRB4 and FOXP3 are both involved in more than one shared biological process. Evidence indicates that T cells transduced with one of these entities exhibit ... | |
medium_convergence_06901 | COPB1 and COG3 share a common binding partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatomer consisting of beta- and delta-COPs that is able to bind to Golgi membranes in an ARF1- and GTP-dependent manner.' Which protein is encoded by the gene corresponding to this sh... | Coatomer subunit zeta-1 | Medium | convergence | {"qa_id":"medium_convergence_06901","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPB1 and COG3 share a common binding partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatomer consisting o... | |
medium_convergence_06902 | PHB2 and BRD4 both interact with a shared protein. Evidence for one such shared partner states: 'In the present study, using the yeast two-hybrid system, we have found that this protein interacts with the PHB2 protein.' Which protein product is encoded by this shared partner? | E3 ubiquitin-protein ligase RING2 | Medium | convergence | {"qa_id":"medium_convergence_06902","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PHB2 and BRD4 both interact with a shared protein. Evidence for one such shared partner states: 'In the present study, using the yeast two-hybrid system, we ... | |
medium_convergence_06903 | Both SIN3B and SIN3A interact with a cell cycle-regulated protein that binds to the SIN3-HDAC complex. Evidence indicates that this protein is enriched in a specific cell type. Which cell type is associated with this protein via an 'enriched in' relationship? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_06903","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both SIN3B and SIN3A interact with a cell cycle-regulated protein that binds to the SIN3-HDAC complex. Evidence indicates that this protein is enriched in a ... | |
medium_convergence_06905 | CHEK2 and FAM175A (Abraxas) share binding partners. One shared partner is involved in a complex where Abraxas recruits the ubiquitin-interacting motif (UIM)-containing protein to BRCA1. Which disease is associated with this specific shared partner? | lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06905","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK2 and FAM175A (Abraxas) share binding partners. One shared partner is involved in a complex where Abraxas recruits the ubiquitin-interacting motif (UIM)-... | |
medium_convergence_06906 | NCOA1 and NCOR2 both interact with a shared protein. Evidence regarding this shared protein states: 'In electrophoretic mobility shift assays, wild-type [thyroid hormone receptor beta] interacted with N-CoR in the absence of ligand, whereas T3 caused dissociation of the [thyroid hormone receptor beta]/N-CoR complex and... | basophil | Medium | convergence | {"qa_id":"medium_convergence_06906","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCOA1 and NCOR2 both interact with a shared protein. Evidence regarding this shared protein states: 'In electrophoretic mobility shift assays, wild-type [thy... | |
medium_convergence_06907 | F2RL2 and PARD3 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The cell polarity protein PAR3, conserved from the nematode to the vertebrate, forms a complex with PAR6 and atypical protein kinase C (aPKC), and the protein complex occurs at the tight junctio... | Protein kinase C zeta type | Medium | convergence | {"qa_id":"medium_convergence_06907","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"F2RL2 and PARD3 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The cell polarity protein PAR3,... | |
medium_convergence_06908 | SYK and CBL both interact with a shared protein. Evidence indicates that in Jurkat T cells, SYK associates with and phosphorylates this shared protein. Which protein is encoded by the gene corresponding to this shared entity? | E3 ubiquitin-protein ligase CBL-B | Medium | convergence | {"qa_id":"medium_convergence_06908","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SYK and CBL both interact with a shared protein. Evidence indicates that in Jurkat T cells, SYK associates with and phosphorylates this shared protein. Which... | |
medium_convergence_06909 | STIP1 and PRKN (Parkin) share interaction partners. One such shared partner is supported by evidence showing that endogenous Parkin and this partner co-immunoprecipitated from HEK293 cells, SH-SY5Y cells, and adult mouse brain. Which protein is encoded by the gene corresponding to this shared interaction partner? | Activating molecule in BECN1-regulated autophagy protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06909","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STIP1 and PRKN (Parkin) share interaction partners. One such shared partner is supported by evidence showing that endogenous Parkin and this partner co-immun... | |
medium_convergence_06910 | Glimepiride and Dapsone share a common interacting drug. Evidence indicates a pharmacological interaction occurs when this shared drug is used in combination with rifampicin. Which disease is this shared drug indicated for? | gout | Medium | convergence | {"qa_id":"medium_convergence_06910","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Glimepiride and Dapsone share a common interacting drug. Evidence indicates a pharmacological interaction occurs when this shared drug is used in combination... | |
medium_convergence_06911 | Vaccinia virus and Human betaherpesvirus 5 both downregulate the expression of a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), the downregulation of this gene was associated with a log2 fold change of -1.410 and an adjusted p-value of 0.0336. Which protein is encoded by this gene? | Dual serine/threonine and tyrosine protein kinase | Medium | convergence | {"qa_id":"medium_convergence_06911","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate the expression of a specific gene. In a study using a cervical adenocarcinoma cell line (GSE1123... | |
medium_convergence_06912 | GTF2B and CCNH both interact with a shared protein partner. Evidence regarding this partner states: 'Analyses of the binding of this motif to other general transcription factors showed that the former class was defective in binding to the basic helix-loop-helix motif of TFIIEβ and the latter class was defective in bind... | General transcription factor IIE subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_06912","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2B and CCNH both interact with a shared protein partner. Evidence regarding this partner states: 'Analyses of the binding of this motif to other general t... | |
medium_convergence_06913 | RHOB and LGALS3 both interact with a shared protein. Experimental evidence, including pull-down assays, gel filtration, and biolayer interferometry, demonstrates that galectin-3 binds to the ectodomain of this shared interaction partner. Which protein is encoded by the gene corresponding to this shared interaction part... | Cell surface glycoprotein MUC18 | Medium | convergence | {"qa_id":"medium_convergence_06913","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOB and LGALS3 both interact with a shared protein. Experimental evidence, including pull-down assays, gel filtration, and biolayer interferometry, demonstr... | |
medium_convergence_06914 | The biological processes 'regulation of gamma-aminobutyric acid secretion' and 'regulation of glycine secretion, neurotransmission' share a common parent process. Evidence regarding one of the child processes states: 'Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyri... | organic acid transport | Medium | convergence | {"qa_id":"medium_convergence_06914","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'regulation of gamma-aminobutyric acid secretion' and 'regulation of glycine secretion, neurotransmission' share a common parent pro... | |
medium_convergence_06915 | EP300 and RB1 both interact with a specific shared protein. Experimental evidence indicates that p300 coimmunoprecipitates with this protein in extracts from murine erythroleukemia (MEL) cells induced to differentiate with dimethylsulfoxide (DMSO), and that p300 and this protein are found together in a common E box DNA... | T-cell acute lymphocytic leukemia protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06915","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and RB1 both interact with a specific shared protein. Experimental evidence indicates that p300 coimmunoprecipitates with this protein in extracts from... | |
medium_convergence_06916 | NDRG1 and SLC6A15 both interact with a specific shared protein. Experimental evidence indicates that NDRG1 specifically interacts with the constitutively active Q67L mutant of this protein, but not with its GDP-bound S22N mutant, thereby identifying NDRG1 as a novel effector of this protein. Which gene encodes this sha... | Ras-related protein Rab-4A | Medium | convergence | {"qa_id":"medium_convergence_06916","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NDRG1 and SLC6A15 both interact with a specific shared protein. Experimental evidence indicates that NDRG1 specifically interacts with the constitutively act... | |
medium_convergence_06917 | HSPA1A and HSPA8 both interact with a shared gene product. Evidence regarding one such shared entity states: 'Analyses of the cotransporter immunoprecipitates revealed that it formed complexes with the core chaperones Hsp90, Hsp70, and Hsp40.' Which cell type is this entity enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_06917","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA1A and HSPA8 both interact with a shared gene product. Evidence regarding one such shared entity states: 'Analyses of the cotransporter immunoprecipitate... | |
medium_convergence_06918 | DTNA and SGCB each interact with more than one shared protein partner. Evidence concerning one shared entity reports that dystrobrevin binds directly to the syntrophins, a heterologous group of dystrophin-associated proteins. Which protein is connected to that entity through the 'encodes' relationship? | Alpha-1-syntrophin | Medium | convergence | {"qa_id":"medium_convergence_06918","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DTNA and SGCB each interact with more than one shared protein partner. Evidence concerning one shared entity reports that dystrobrevin binds directly to the ... | |
medium_convergence_06919 | Influenza A virus and Pegivirus C both upregulate a specific gene. Experimental data from bronchial epithelial cells (study GSE147507) indicates that for one such shared target, the log2 fold change is approximately 1.073 and the adjusted p-value is 0.0004003. Which protein is encoded by this gene? | UBA-like domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_06919","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Influenza A virus and Pegivirus C both upregulate a specific gene. Experimental data from bronchial epithelial cells (study GSE147507) indicates that for one... | |
medium_convergence_06920 | CRK and KDR each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we present the crystal structure of a ligand bound to the VEGFR-2 high-affinity-binding site, which consists of immunoglobulin homology domains D2 and D3.' Which protein is connected to that entity through ... | Vascular endothelial growth factor C | Medium | convergence | {"qa_id":"medium_convergence_06920","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and KDR each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we present the crystal structure of a ligan... | |
medium_convergence_06921 | DDX1 and RBMX both interact with a shared protein. Evidence identifies this shared protein as a deubiquitinase that acts as a central coordinator, interacting and co-localizing with RTCB and DDX1. Which protein is encoded by this shared entity? | Ubiquitin carboxyl-terminal hydrolase 45 | Medium | convergence | {"qa_id":"medium_convergence_06921","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDX1 and RBMX both interact with a shared protein. Evidence identifies this shared protein as a deubiquitinase that acts as a central coordinator, interactin... | |
medium_convergence_06922 | CRKL and JAK2 each interact with more than one shared gene product. Evidence concerning one shared entity reports that it constitutively binds to the guanine nucleotide-releasing protein, a specific GEF, via direct SH3 domain binding. Which disease is connected to that entity through a causal relationship? | lymphoma | Medium | convergence | {"qa_id":"medium_convergence_06922","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRKL and JAK2 each interact with more than one shared gene product. Evidence concerning one shared entity reports that it constitutively binds to the guanine... | |
medium_convergence_06923 | ATG16L1 and YWHAH both interact with a shared protein. Evidence regarding this shared protein states: 'In this study, we show that the protein encoded by ZFP36 and the related proteins TIS11b and TIS11d bind specifically to 14-3-3 proteins and that individual 14-3-3 isoforms preferentially bind to different phosphoryla... | mRNA decay activator protein ZFP36 | Medium | convergence | {"qa_id":"medium_convergence_06923","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATG16L1 and YWHAH both interact with a shared protein. Evidence regarding this shared protein states: 'In this study, we show that the protein encoded by ZFP... | |
medium_convergence_06925 | HDAC1 and MYC share multiple interacting partners. One such shared partner is reported to directly interact with MYC and co-occupy a distal regulatory element of SOX2 to activate SOX2 expression, a mechanism likely involved in neuroectoderm differentiation. Which protein is encoded by this shared partner? | Polycomb group RING finger protein 6 | Medium | convergence | {"qa_id":"medium_convergence_06925","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and MYC share multiple interacting partners. One such shared partner is reported to directly interact with MYC and co-occupy a distal regulatory elemen... | |
medium_convergence_06926 | BAMBI and BMPR1B both interact with a common protein partner. Evidence regarding this partner states: 'Using antibody-mediated immunofluorescence copatching of epitope-tagged receptors, we provide evidence in live cells for preexisting heteromeric (BR-II/BR-Ia and BR-II/BR-Ib) and homomeric (BR-II/BR-II, BR-Ia/ BR-Ia, ... | Bone morphogenetic protein receptor type-1A | Medium | convergence | {"qa_id":"medium_convergence_06926","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BAMBI and BMPR1B both interact with a common protein partner. Evidence regarding this partner states: 'Using antibody-mediated immunofluorescence copatching ... | |
medium_convergence_06927 | COPE and COPA share interaction partners. One such shared partner was identified in a study reporting, for the first time, members of the coatomer I (COPI) complex as interaction partners of hSAC1. Which biological process is this specific shared partner involved in? | phosphatidylinositol dephosphorylation | Medium | convergence | {"qa_id":"medium_convergence_06927","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPE and COPA share interaction partners. One such shared partner was identified in a study reporting, for the first time, members of the coatomer I (COPI) c... | |
medium_convergence_06928 | PPARGC1A and NCOA6 both interact with a specific nuclear receptor. Evidence regarding this interaction states: 'This agonist-dependent PGC-1/TR interaction also requires both helix 1 and the AF-2 region of the TR ligand-binding domain.' Which protein is encoded by the gene corresponding to this nuclear receptor? | Thyroid hormone receptor beta | Medium | convergence | {"qa_id":"medium_convergence_06928","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPARGC1A and NCOA6 both interact with a specific nuclear receptor. Evidence regarding this interaction states: 'This agonist-dependent PGC-1/TR interaction a... | |
medium_convergence_06929 | RBCK1 and MAVS both interact with a common protein. Evidence regarding this shared partner states: 'Mechanistically, we show that TRIM18 recruits protein phosphatase 1A (PPM1A) to dephosphorylate a kinase, which inactivates it to block it from interacting with its upstream adaptors, mitochondrial antiviral signaling (M... | Serine/threonine-protein kinase TBK1 | Medium | convergence | {"qa_id":"medium_convergence_06929","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RBCK1 and MAVS both interact with a common protein. Evidence regarding this shared partner states: 'Mechanistically, we show that TRIM18 recruits protein pho... | |
medium_convergence_06930 | DDB1 and PRKN (PARK2) share interaction partners. One such shared partner localizes to photolesions and associates with DDB1 to promote the assembly and activity of the DDB2-DDB1-Cul4A-Roc1 (CRL4(DDB2)) ubiquitin ligase complex. Which protein is encoded by the gene corresponding to this shared partner? | UV radiation resistance-associated gene protein | Medium | convergence | {"qa_id":"medium_convergence_06930","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDB1 and PRKN (PARK2) share interaction partners. One such shared partner localizes to photolesions and associates with DDB1 to promote the assembly and acti... | |
medium_convergence_06931 | FANCC and FANCD2 both interact with a specific shared protein. Evidence indicates that a central region of this shared protein is sufficient for binding to FANCC. Which protein is encoded by the gene corresponding to this shared entity? | Fanconi anemia group E protein | Medium | convergence | {"qa_id":"medium_convergence_06931","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCC and FANCD2 both interact with a specific shared protein. Evidence indicates that a central region of this shared protein is sufficient for binding to F... | |
medium_convergence_06932 | ANAPC16 and CDC20 each interact with more than one shared protein partner. Evidence concerning one such shared entity reports that a human protein also binds APC16 and APC7 and contains a >200-residue loop that is heavily phosphorylated during mitosis, although the basis for its interactions and whether loop phosphoryl... | Cell division cycle protein 27 homolog | Medium | convergence | {"qa_id":"medium_convergence_06932","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC16 and CDC20 each interact with more than one shared protein partner. Evidence concerning one such shared entity reports that a human protein also binds... | |
medium_convergence_06933 | PRKN and UBC share multiple interacting partners. One such shared partner is characterized by structural studies showing that its ubiquitin-binding site overlaps with the myosin VI binding site, and that point mutations in its zinc finger domains, which impair ubiquitin binding, also abolish binding to myosin VI. Which... | Tax1-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06933","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and UBC share multiple interacting partners. One such shared partner is characterized by structural studies showing that its ubiquitin-binding site over... | |
medium_convergence_06934 | UBE2E3 and HSP90AA1 both interact with a specific shared protein. Evidence indicates that this shared protein forms stable DDD-E2 complexes, consisting of DDB1, DDA1 (also known as DDB1 associated 1), and a member of the UBE2E group of canonical ubiquitin-conjugating enzymes. Which protein is encoded by the gene corres... | DET1 homolog | Medium | convergence | {"qa_id":"medium_convergence_06934","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBE2E3 and HSP90AA1 both interact with a specific shared protein. Evidence indicates that this shared protein forms stable DDD-E2 complexes, consisting of DD... | |
medium_convergence_06935 | OPTN and CASP2 both interact with a shared protein. Evidence indicates that Optineurin competitively antagonizes NEMO's binding to polyubiquitinated RIPK1 and that its overexpression inhibits TNFalpha-induced NF-kappaB activation. Which protein is encoded by the gene corresponding to this shared interaction partner? | Receptor-interacting serine/threonine-protein kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_06935","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OPTN and CASP2 both interact with a shared protein. Evidence indicates that Optineurin competitively antagonizes NEMO's binding to polyubiquitinated RIPK1 an... | |
medium_convergence_06936 | ANAPC10 and ANAPC11 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Both APC11 and UbcH10 bind to the C-terminal cullin homology domain of this partner, whereas Ubc4 interacts with APC11 directly.' Which disease is associated with that specific shared partne... | colitis | Medium | convergence | {"qa_id":"medium_convergence_06936","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC10 and ANAPC11 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'Both APC11 and UbcH10 bind ... | |
medium_convergence_06939 | OST4 and MAGT1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that Co-immunoprecipitation studies suggest this entity associates with both STT3 isoforms and with ribophorin I, an accessory subunit of mammalian oligosaccharyltransferases (OSTs). Which ... | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B | Medium | convergence | {"qa_id":"medium_convergence_06939","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OST4 and MAGT1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that Co-immunoprecipitatio... | |
medium_convergence_06940 | Both Human betaherpesvirus 5 and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data from a study on retinal pigment epithelium cell lines (GSE120891) indicates that this gene exhibits a log2 fold change of approximately 2.088 and an adjusted p-value of 0.001383. In which cellular c... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_06940","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human betaherpesvirus 5 and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data from a study on retinal pigment epi... | |
medium_convergence_06941 | FANCE and FAN1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'In normal cells, HA-tagged FANCE protein coimmunoprecipitates with FANCA, FANCC, and this shared partner but not with FANCD2.' Which protein is encoded by that shared partner? | Fanconi anemia group G protein | Medium | convergence | {"qa_id":"medium_convergence_06941","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCE and FAN1 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'In normal cells, HA-tagged FANCE prot... | |
medium_convergence_06942 | TRIM28 and AGR2 both interact with a shared protein. Evidence indicates that the interaction between KAP-1 and this shared protein was verified by co-immunoprecipitation (Co-IP). Which protein is encoded by this shared gene? | Probable ATP-dependent RNA helicase DDX5 | Medium | convergence | {"qa_id":"medium_convergence_06942","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and AGR2 both interact with a shared protein. Evidence indicates that the interaction between KAP-1 and this shared protein was verified by co-immunop... | |
medium_convergence_06943 | TRIM28 and PPP1CC both interact with a shared protein. Evidence regarding this shared protein states: 'We show here that mutation of these phosphatase-interaction sites did not completely abolish the ability of the shared protein to bind and inhibit PP1(C).' Which protein is encoded by the gene corresponding to this sh... | Nuclear inhibitor of protein phosphatase 1 | Medium | convergence | {"qa_id":"medium_convergence_06943","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and PPP1CC both interact with a shared protein. Evidence regarding this shared protein states: 'We show here that mutation of these phosphatase-intera... | |
medium_convergence_06944 | BIRC2 and RNF31 both interact with a specific shared protein. Evidence indicates that this protein interacts via its PUB domain with CYLD, and a PUB interaction motif (PIM) within this protein binds to the PUB domain of the LUBAC component HOIP. Which disease is associated with this protein as a biomarker? | thymic carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06944","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and RNF31 both interact with a specific shared protein. Evidence indicates that this protein interacts via its PUB domain with CYLD, and a PUB interact... | |
medium_convergence_06945 | FKBP5 and HSP90AA1 both interact with a specific gene product. Evidence indicates that this product, referred to as a testis-specific kinase, specifically interacts with HSP90-1beta, HSC70, and HSP70 proteins, an association required for its kinase activity. Which protein is encoded by this gene? | Testis-specific serine/threonine-protein kinase 6 | Medium | convergence | {"qa_id":"medium_convergence_06945","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FKBP5 and HSP90AA1 both interact with a specific gene product. Evidence indicates that this product, referred to as a testis-specific kinase, specifically in... | |
medium_convergence_06946 | ASAP1 and EXOC1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Both coimmunoprecipitation and in vitro pulldown assays confirmed that ASAP1 directly binds to FIP3 through its BAR domain.' Which disease is associated with that specific entity via a biom... | spina bifida cystica | Medium | convergence | {"qa_id":"medium_convergence_06946","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ASAP1 and EXOC1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Both coimmunoprecipitation... | |
medium_convergence_06948 | COPA and CD59 share common binding partners. One such shared partner is supported by evidence stating: 'Immunoprecipitation, as well as analysis exploiting the two-hybrid system in a complete COP screen, showed physical interactions between alpha- and epsilon-COPs and between beta- and delta-COPs.' Which disease is ass... | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_06948","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPA and CD59 share common binding partners. One such shared partner is supported by evidence stating: 'Immunoprecipitation, as well as analysis exploiting t... | |
medium_convergence_06949 | EDN1 and LAMTOR3 both interact with a shared protein. Evidence regarding this shared protein states: 'In a two-hybrid screen with p14 as a bait, we identified the mitogen-activated protein kinase (MAPK) scaffolding protein MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) partner 1 (MP1) as an interacting p... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_06949","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EDN1 and LAMTOR3 both interact with a shared protein. Evidence regarding this shared protein states: 'In a two-hybrid screen with p14 as a bait, we identifie... | |
medium_convergence_06950 | EGFR and HRAS both interact with a specific shared protein. Evidence regarding this shared protein states: 'In line with functional interactions, EGFR and DEP-1 form physical associations, and EGFR phosphorylates a substrate-trapping mutant of DEP-1.' Which protein is encoded by the gene corresponding to this shared en... | Receptor-type tyrosine-protein phosphatase eta | Medium | convergence | {"qa_id":"medium_convergence_06950","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and HRAS both interact with a specific shared protein. Evidence regarding this shared protein states: 'In line with functional interactions, EGFR and DE... | |
medium_convergence_06951 | KAT5 and BRD8 both interact with a shared protein. Evidence indicates that this protein is a stable subunit of the NuA4/TIP60 complex and, via a histone reader domain for H4K20me1/2, allows TIP60 to associate with specific gene promoters to promote the repair of DNA double-strand breaks by homologous recombination. Whi... | MBT domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06951","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and BRD8 both interact with a shared protein. Evidence indicates that this protein is a stable subunit of the NuA4/TIP60 complex and, via a histone read... | |
medium_convergence_06953 | NCOA6 and RXRA both interact with a shared protein entity. Evidence indicates that this entity, identified as ASC-2, interacts with other nuclear receptors including the retinoic acid receptor, thyroid hormone receptor, estrogen receptor alpha, and glucocorticoid receptor, as well as basal factors TFIIA and TBP, and tr... | Thyroid hormone receptor alpha | Medium | convergence | {"qa_id":"medium_convergence_06953","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NCOA6 and RXRA both interact with a shared protein entity. Evidence indicates that this entity, identified as ASC-2, interacts with other nuclear receptors i... | |
medium_convergence_06954 | IL23R and IL23A are both involved in more than one shared biological process. One such shared process is supported by evidence stating: 'Our findings show that IL-23 and IL-18 synergistically elicit IFN-gamma production in NK-like T cells but not in NK cells.' Which biological process, connected to this shared entity v... | NK T cell activation | Medium | convergence | {"qa_id":"medium_convergence_06954","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL23R and IL23A are both involved in more than one shared biological process. One such shared process is supported by evidence stating: 'Our findings show th... | |
medium_convergence_06955 | EGLN3 and EP300 each interact with more than one shared gene product. Evidence concerning one of these shared entities states: 'Whereas CBP can bind with HIF-2α independent of the HIF-2α C-terminal activation domain via enzyme/substrate interactions, p300 only complexes with HIF-2α through the C-terminal activation dom... | transcription regulator complex | Medium | convergence | {"qa_id":"medium_convergence_06955","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGLN3 and EP300 each interact with more than one shared gene product. Evidence concerning one of these shared entities states: 'Whereas CBP can bind with HIF... | |
medium_convergence_06956 | BIRC5 and AURKB each share a binding partner. Evidence concerning one of these shared partners reports that Aurora B directly binds to the substrate-recognition domain of this entity in vitro and coimmunoprecipitates with the Cul3 complex during mitosis. Which gene is connected to this entity through an 'interacts with... | KLHL21 | Medium | convergence | {"qa_id":"medium_convergence_06956","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC5 and AURKB each share a binding partner. Evidence concerning one of these shared partners reports that Aurora B directly binds to the substrate-recognit... | |
medium_convergence_06957 | Both ABL1 and MYH9 interact with a specific shared gene product. Evidence indicates that transformation with the oncogene v-abl leads to increased tyrosine phosphorylation of this shared entity, mediated by a direct association between this shared entity and v-Abl. Which disease is associated with this shared entity vi... | Hodgkins lymphoma | Medium | convergence | {"qa_id":"medium_convergence_06957","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ABL1 and MYH9 interact with a specific shared gene product. Evidence indicates that transformation with the oncogene v-abl leads to increased tyrosine p... | |
medium_convergence_06958 | HDAC1 and NCOR1 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports that Myt1 complexes were co-immunoprecipitated from transfected mammalian cells and included this partner along with HDAC2. Which protein is encoded by the gene corresponding to that shared partn... | Paired amphipathic helix protein Sin3b | Medium | convergence | {"qa_id":"medium_convergence_06958","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and NCOR1 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports that Myt1 complexes were co-immu... | |
medium_convergence_06959 | CSNK2A1 and MSH2 share a common interaction partner. Evidence indicates that PKC zeta interacts with this shared entity and with MSH6, phosphorylating both. Which protein is encoded by this shared entity? | Protein kinase C zeta type | Medium | convergence | {"qa_id":"medium_convergence_06959","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and MSH2 share a common interaction partner. Evidence indicates that PKC zeta interacts with this shared entity and with MSH6, phosphorylating both. ... | |
medium_convergence_06961 | Enterovirus A and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells shows a log2 fold change of -2.163 and an adjusted p-value of 0.03916. Which protein is encoded by this gene? | Thromboxane-A synthase | Medium | convergence | {"qa_id":"medium_convergence_06961","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Zaire ebolavirus both downregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells shows a log2 fold change of -... | |
medium_convergence_06962 | Both Measles morbillivirus and Dengue virus are known to upregulate a specific shared gene. Experimental data for this gene in pleural mesothelioma cells (from study GSE117668) reports a log2 fold change of approximately 1.304 and an adjusted p-value of 0.0004566. Which disease is associated with this gene through geno... | lung neoplasm | Medium | convergence | {"qa_id":"medium_convergence_06962","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Dengue virus are known to upregulate a specific shared gene. Experimental data for this gene in pleural mesothelioma cells (fr... | |
medium_convergence_06963 | HDAC1 and SMAD4 share multiple interacting partners. One such partner is described in a study stating: 'In this study, we show that a specific transcription factor can interact directly with Smad4 both in vitro and in vivo.' Which protein is encoded by this shared interacting partner? | Zinc finger and BTB domain-containing protein 7A | Medium | convergence | {"qa_id":"medium_convergence_06963","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and SMAD4 share multiple interacting partners. One such partner is described in a study stating: 'In this study, we show that a specific transcription ... | |
medium_convergence_06964 | CAND1 and CUL1 each bind to more than one shared gene. Evidence concerning one shared entity reports that recombinant versions of this entity associate with recombinant Skp1 and CUL1 in vitro, even in the absence of recombinant Cry1. Which gene is connected to this entity through an 'interacts with' relationship? | TCAP | Medium | convergence | {"qa_id":"medium_convergence_06964","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAND1 and CUL1 each bind to more than one shared gene. Evidence concerning one shared entity reports that recombinant versions of this entity associate with ... | |
medium_convergence_06965 | COPB1 and COG3 share a common binding partner. Evidence regarding this shared partner states: 'Herein we describe isolation of a subcomplex of coatomer consisting of beta- and delta-COPs that is able to bind to Golgi membranes in an ARF1- and GTP-dependent manner.' Which gene interacts with this shared partner? | MATR3 | Medium | convergence | {"qa_id":"medium_convergence_06965","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPB1 and COG3 share a common binding partner. Evidence regarding this shared partner states: 'Herein we describe isolation of a subcomplex of coatomer consi... | |
medium_convergence_06966 | Human orthopneumovirus and Primate bocaparvovirus 1 are both reported to upregulate a specific shared gene. Experimental evidence for this gene in a non-small cell lung adenocarcinoma cell line shows a log2 fold change of approximately 2.37 and an adjusted p-value of 0.0284. What molecular function is enabled by this g... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_06966","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human orthopneumovirus and Primate bocaparvovirus 1 are both reported to upregulate a specific shared gene. Experimental evidence for this gene in a non-smal... | |
medium_convergence_06967 | CHD3 and SIRT1 share common interaction partners. One such shared partner is characterized by evidence showing that SIRT1 interacts directly with it and is recruited to the promoter template in a partner-dependent manner, resulting in transcriptional repression. Which disease is associated with this specific shared par... | stroke disorder | Medium | convergence | {"qa_id":"medium_convergence_06967","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and SIRT1 share common interaction partners. One such shared partner is characterized by evidence showing that SIRT1 interacts directly with it and is r... | |
medium_convergence_06968 | CHD3 and HDAC1 share multiple interacting partners. One such shared partner is reported to be associated with histone demethylase complexes containing lysine-specific demethylase 1 (LSD1), RE1 silencing transcription factor corepressor (CoREST), histone deacetylase 1, and histone deacetylase 2 in erythroleukemia and T ... | disseminated intravascular coagulation | Medium | convergence | {"qa_id":"medium_convergence_06968","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and HDAC1 share multiple interacting partners. One such shared partner is reported to be associated with histone demethylase complexes containing lysine... | |
medium_convergence_06969 | Both Human respirovirus 3 and Rift Valley fever phlebovirus are associated with the upregulation of a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) reports a log2 fold change of approximately 2.408 and an adjusted p-value of 0.04933. What protein is e... | Guanylate-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_06969","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Rift Valley fever phlebovirus are associated with the upregulation of a specific gene. Experimental data for this gene in a non... | |
medium_convergence_06970 | GTF2H4 and POLD1 both interact with a common protein partner. Experimental evidence regarding this partner states: 'These assays revealed that p12 interacts with p125 as well as p50.' Which protein is encoded by this shared partner? | DNA polymerase delta subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_06970","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2H4 and POLD1 both interact with a common protein partner. Experimental evidence regarding this partner states: 'These assays revealed that p12 interacts ... | |
medium_convergence_06971 | Both IKBKB and MAVS interact with a common protein partner. For one such partner, evidence indicates that FAF1 binds competitively to it and positively regulates type I interferon signaling by disrupting the interaction between this partner and MAVS. Which protein is encoded by the gene corresponding to this partner? | NLR family member X1 | Medium | convergence | {"qa_id":"medium_convergence_06971","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IKBKB and MAVS interact with a common protein partner. For one such partner, evidence indicates that FAF1 binds competitively to it and positively regul... | |
medium_convergence_06972 | ARCN1 and COG6 share a common interacting partner. Evidence regarding this shared partner includes reports of immunoprecipitation and two-hybrid system analysis within a complete COP screen, demonstrating physical interactions between alpha- and epsilon-COPs, as well as between beta- and delta-COPs. Which disease is as... | Baralle-Macken syndrome | Medium | convergence | {"qa_id":"medium_convergence_06972","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARCN1 and COG6 share a common interacting partner. Evidence regarding this shared partner includes reports of immunoprecipitation and two-hybrid system analy... | |
medium_convergence_06973 | Fluconazole and Morphine both interact with a specific drug. Evidence regarding this drug includes a kinetic and dynamic interaction study involving ketoconazole, itraconazole, and the drug itself. Which disease is this drug indicated for? | insomnia | Medium | convergence | {"qa_id":"medium_convergence_06973","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Fluconazole and Morphine both interact with a specific drug. Evidence regarding this drug includes a kinetic and dynamic interaction study involving ketocona... | |
medium_convergence_06974 | Measles morbillivirus and Rift Valley fever phlebovirus both upregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) reports a log2 fold change of approximately 1.796 and an adjusted p-value of 0.02433. Which disease is associated with this gene as a biomarker? | major depressive disorder | Medium | convergence | {"qa_id":"medium_convergence_06974","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Rift Valley fever phlebovirus both upregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (study... | |
medium_convergence_06975 | STUB1 and CCT4 both interact with a shared gene product. Evidence regarding this shared entity indicates that CHIP is a cytosolic U-box protein that interacts with Hsc70 through a set of tetratricopeptide motifs. Which cell type is enriched for this shared entity? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06975","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STUB1 and CCT4 both interact with a shared gene product. Evidence regarding this shared entity indicates that CHIP is a cytosolic U-box protein that interact... | |
medium_convergence_06976 | GRB2 and DOK2 both interact with a common protein. Evidence for one such shared partner states: 'In this study, we describe the specific interaction of this protein with the Grb2 adapter protein both in vitro and in vivo.' Which cell type is this shared protein enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06976","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and DOK2 both interact with a common protein. Evidence for one such shared partner states: 'In this study, we describe the specific interaction of this ... | |
medium_convergence_06977 | Human respirovirus 3 and Human immunodeficiency virus 1 both upregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) reports a log2 fold change of approximately 1.23 and an adjusted p-value of approximately 0.047. Which disease is associated with t... | chronic hepatitis B virus infection | Medium | convergence | {"qa_id":"medium_convergence_06977","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Human immunodeficiency virus 1 both upregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcin... | |
medium_convergence_06978 | ERCC1 and FANCF both interact with a specific protein. Evidence indicates that this protein forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with the MSH2/MSH3 mismatch repair complex, the telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kina... | Structure-specific endonuclease subunit SLX4 | Medium | convergence | {"qa_id":"medium_convergence_06978","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC1 and FANCF both interact with a specific protein. Evidence indicates that this protein forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME... | |
medium_convergence_06979 | Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data for this gene indicates a log2 fold change of -1.169 and an adjusted p-value of 0.0004793. In which cell type is this gene enriched? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_06979","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are associated with the downregulation of a specific gene. Experimental data for this gene indicates a log2 fold... | |
medium_convergence_06980 | LIN37 and LIN52 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'In proliferating cells, a Myb family transcription factor interacts with the MuvB core complex including LIN9, LIN37, LIN52, RBBP4, and LIN54, forming the MMB (Myb-MuvB) complex.' Which cell type is ... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_06980","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LIN37 and LIN52 each interact with more than one shared protein partner. Evidence concerning one shared entity reports: 'In proliferating cells, a Myb family... | |
medium_convergence_06981 | GH2 and GHR each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In this assay, only TC-PTP, [protein encoded by PTPN1], PTP-H1, and SAP-1 interacted with the mature form of the phosphorylated GHR.' Which protein is encoded by that entity? | Tyrosine-protein phosphatase non-receptor type 1 | Medium | convergence | {"qa_id":"medium_convergence_06981","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GH2 and GHR each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In this assay, only TC-PTP, [protein encoded by ... | |
medium_convergence_06982 | DDB1 and PCNA both interact with a specific shared protein. Experimental evidence indicates that recombinant DDB1 and this shared protein bind directly to each other in vitro, and that ectopically expressed DDB1 bridges this shared protein to CUL4A in vivo. Which protein is encoded by the gene corresponding to this sha... | DNA replication factor Cdt1 | Medium | convergence | {"qa_id":"medium_convergence_06982","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDB1 and PCNA both interact with a specific shared protein. Experimental evidence indicates that recombinant DDB1 and this shared protein bind directly to ea... | |
medium_convergence_06983 | DLG3 and GRIK2 each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that PSD-95 binds to and co-localizes with NMDA receptors at postsynaptic sites. Which protein is encoded by the gene corresponding to that shared partner? | Glutamate receptor ionotropic, NMDA 2A | Medium | convergence | {"qa_id":"medium_convergence_06983","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG3 and GRIK2 each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that PSD-95 binds to and co-loc... | |
medium_convergence_06984 | RHOA and RHOC both interact with a specific downstream effector protein. Evidence regarding this effector states: 'The similarity of RhoE and RhoA sequences suggested that RhoE might compete with RhoA for interaction with its targets.' Which protein is encoded by the gene corresponding to this effector? | Rho-associated protein kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_06984","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RHOA and RHOC both interact with a specific downstream effector protein. Evidence regarding this effector states: 'The similarity of RhoE and RhoA sequences ... | |
medium_convergence_06985 | HDAC2 and LEF1 share multiple binding partners. One such partner is described by the evidence: 'We show that TLE/Gro interacts with LEF-1 and Pan, and inhibits LEF-1:beta-catenin-dependent transcription.' Which cell type is this specific partner enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_06985","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC2 and LEF1 share multiple binding partners. One such partner is described by the evidence: 'We show that TLE/Gro interacts with LEF-1 and Pan, and inhibi... | |
medium_convergence_06986 | PSMC4 and PSMC6 both interact with a shared protein. Evidence for one of these shared partners states: 'A yeast two-hybrid screen with the human S6 (TBP7, RPT3) ATPase of the 26 S proteasome has identified gankyrin, a liver oncoprotein, as an interacting protein.' Which disease is associated with this specific shared p... | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_06986","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMC4 and PSMC6 both interact with a shared protein. Evidence for one of these shared partners states: 'A yeast two-hybrid screen with the human S6 (TBP7, RP... | |
medium_convergence_06988 | AURKB and CKAP5 both interact with a specific protein. Evidence regarding this protein states: 'We have delineated here the interactions of this protein with four proteins, namely the microtubule-associated chTOG (colonic and hepatic tumor-overexpressed gene) protein (ortholog of Drosophila MSPS), the adaptor protein T... | glioblastoma | Medium | convergence | {"qa_id":"medium_convergence_06988","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AURKB and CKAP5 both interact with a specific protein. Evidence regarding this protein states: 'We have delineated here the interactions of this protein with... | |
medium_convergence_06989 | ARFRP1 and ARL1 both interact with a shared protein. Evidence indicates that the GTP-bound form of this shared protein interacts with the GRIP domains of Golgin-97 and a second golgin, a process dependent on conserved residues within those GRIP domains that are critical for Golgi targeting. In which cell type is this s... | gamma-delta T cell | Medium | convergence | {"qa_id":"medium_convergence_06989","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARFRP1 and ARL1 both interact with a shared protein. Evidence indicates that the GTP-bound form of this shared protein interacts with the GRIP domains of Gol... | |
medium_convergence_06990 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of -3.478 and an adjusted p-value of 0.03439. In which cell type is this gene enriched? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_06990","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study G... | |
medium_convergence_06991 | FAAP20 and FANCE both interact with a shared protein entity. Experimental evidence indicates that in normal cells, an HA-tagged version of this shared entity co-immunoprecipitates with FANCA, FANCC, and the entity itself, but does not co-immunoprecipitate with FANCD2. Which cell type is this shared entity enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_06991","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FAAP20 and FANCE both interact with a shared protein entity. Experimental evidence indicates that in normal cells, an HA-tagged version of this shared entity... | |
medium_convergence_06993 | Both Human alphaherpesvirus 3 and Zika virus have been shown to downregulate a specific gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.223 and an adjusted p-value of 5.773e-06. Which protein is encoded by this gene? | DNA mismatch repair protein Msh2 | Medium | convergence | {"qa_id":"medium_convergence_06993","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zika virus have been shown to downregulate a specific gene. Experimental data from a melanoma cell line study (GSE136586) i... | |
medium_convergence_06994 | CBX5 and CBFB both interact with a specific histone H3 variant. Evidence regarding this interaction states: 'We find that the chromoshadow-domain interacts with histone H3 in a region located partially inside the nucleosomal barrel at the entry/exit point of the nucleosome.' Which protein is encoded by this specific hi... | Histone H3.1 | Medium | convergence | {"qa_id":"medium_convergence_06994","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX5 and CBFB both interact with a specific histone H3 variant. Evidence regarding this interaction states: 'We find that the chromoshadow-domain interacts w... |
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