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medium_divergent_branch_02379 | The biological process 'regulation of multicellular organism growth' is defined as any process that modulates the frequency, rate, or extent of growth of the body of an organism so that it reaches its usual body size. This process is a subtype of a broader regulatory process. Which biological process is directly regula... | developmental growth | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02379","source_qa_id":"medium_divergent_branch_05196","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of multicellular organism growth' is defined as any process th... | |
medium_divergent_branch_02380 | ITGB1 interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'Biochemical studies validate the association of a carbonic anhydrase isoform with α2β1 integrin, CD98hc and MMP14, and immunofluorescence microscopy demonstrates colocalization of this isoform with α2β1 integrin an... | urinary bladder carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02380","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITGB1 interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'Biochemical studies validate the associatio... | |
medium_divergent_branch_02381 | MAP1LC3C interacts with multiple proteins. One of these interaction partners is characterized by evidence showing it binds ATG8 family proteins, preferentially LC3C, and directly interacts with SOD1. Which protein corresponds to this description? | Tumor protein p53-inducible nuclear protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02381","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP1LC3C interacts with multiple proteins. One of these interaction partners is characterized by evidence showing it binds ATG8 family proteins, pref... | |
medium_divergent_branch_02382 | POLD3 interacts with multiple proteins. One specific interaction involves a previously unknown RIR motif located in the C-terminal part of the POLD3 subunit of Polζ, which binds tightly to the C-terminus of the interacting partner. Which disease is associated with this specific interacting partner? | Mesothelioma, malignant | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02382","source_qa_id":"medium_divergent_branch_03237","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"POLD3 interacts with multiple proteins. One specific interaction involves a previously unknown RI... | |
medium_divergent_branch_02383 | EEF1D interacts with multiple genes. One of these interactions is supported by evidence stating: 'We further demonstrate that cooperative physical interactions among eEF1BδL, RNF20/40, and this gene synergistically promote expression of heat shock-responsive genes.' Which disease is connected to this gene through a the... | amyotrophic lateral sclerosis type 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02383","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EEF1D interacts with multiple genes. One of these interactions is supported by evidence stating: 'We further demonstrate that cooperative physical in... | |
medium_divergent_branch_02384 | RAF1 interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'Immunoprecipitation, pull-down and confocal fluorescence microscopy experiments demonstrate an interaction between this gene and C-RAF proteins.' Which disease is associated with this specific interacting gene? | macrocephaly, dysmorphic facies, and psychomotor retardation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02384","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAF1 interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'Immunoprecipitation, pull-down and confocal ... | |
medium_divergent_branch_02385 | METTL15 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'Here, we identify METTL15, show that it is the main N4-methylcytidine (m4C) methyltransferase in human cells and demonstrate that it is responsible for the methylation o... | mitochondrion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02385","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"METTL15 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating:... | |
medium_divergent_branch_02386 | BIRC3 interacts with multiple genes. One interaction is supported by evidence stating: 'In this study, we found that XIAP, cIAP1 and cIAP2 not only directly bind to RIP1 and the second interacting partner but also to RIP3 and RIP4.' Which disease is connected to the gene identified by this specific evidence through gen... | allergic asthma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02386","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BIRC3 interacts with multiple genes. One interaction is supported by evidence stating: 'In this study, we found that XIAP, cIAP1 and cIAP2 not only d... | |
medium_divergent_branch_02387 | ADAM10 interacts with multiple proteins. One such interaction involves members of the evolutionarily conserved TspanC8 subfamily of human tetraspanins, which directly interact with ADAM10, regulate its exit from the endoplasmic reticulum, and modulate its surface expression levels. Which protein, encoded by the gene as... | Tetraspanin-5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02387","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAM10 interacts with multiple proteins. One such interaction involves members of the evolutionarily conserved TspanC8 subfamily of human tetraspanin... | |
medium_divergent_branch_02388 | Interleukin-4 (IL4) is associated with multiple biological processes. One specific association is supported by evidence showing that THP-1 cells, after PMA incubation, were induced by IL-4 and IL-13 to become M2-polarized macrophages. Which broader biological category, defined by an 'is a' relationship, encompasses the... | myeloid leukocyte activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02388","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Interleukin-4 (IL4) is associated with multiple biological processes. One specific association is supported by evidence showing that THP-1 cells, aft... | |
medium_divergent_branch_02389 | BMP7 is associated with multiple biological processes. One association is supported by evidence stating: 'These results suggest different mechanisms for BMP-2/4- and BMP-6/7-induced osteoblastic differentiation in primary hMSC.' Identify the biological process that is a part of the process linked to BMP7 by this specif... | ossification | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02389","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMP7 is associated with multiple biological processes. One association is supported by evidence stating: 'These results suggest different mechanisms ... | |
medium_divergent_branch_02390 | PRKCE interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using affinity chromatography and Western blot analysis, we found interaction with all PKC isotypes and casein kinase I isoforms, CKIalpha and CKI.' Which protein, linked to PRKCE by this specific interaction evidence, i... | Protein phosphatase 1 regulatory subunit 14A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02390","source_qa_id":"medium_divergent_branch_04709","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PRKCE interacts with multiple proteins. One specific interaction is supported by evidence stating... | |
medium_divergent_branch_02391 | EIF3G interacts with multiple genes. One of these interacting partners has a direct physical interaction with EIF3G that was confirmed via GST pull-down assays, co-immunoprecipitation, and confocal microscopy. Which disease is associated with this specific interacting gene through genomic alterations? | motor neuron disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02391","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF3G interacts with multiple genes. One of these interacting partners has a direct physical interaction with EIF3G that was confirmed via GST pull-d... | |
medium_divergent_branch_02392 | NOTCH3 is associated with multiple molecular functions via the 'enables' relationship. One line of evidence states: 'we investigated the consequences of three pathogenic Notch3 mutations on the biological activity of the receptor by analyzing ligand (Delta-/Jagged-)-induced signaling via RBP-Jk.' Which molecular functi... | molecular transducer activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02392","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOTCH3 is associated with multiple molecular functions via the 'enables' relationship. One line of evidence states: 'we investigated the consequences... | |
medium_divergent_branch_02393 | NOX4 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating that in Cos7 cells, NOX4 partially localizes to this component. Which cellular component, connected to this identified location via the 'part of' relationship, is the correct... | cell periphery | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02393","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOX4 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating tha... | |
medium_divergent_branch_02394 | IPO11 interacts with multiple proteins. One interaction partner forms a complex with Importin-11 that is disassembled by Ran:GTP but not by Ran:GDP. Which protein, connected to IPO11 via an interaction, is encoded by the gene associated with this specific GTP-dependent disassembly mechanism? | Ubiquitin-conjugating enzyme E2 E1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02394","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IPO11 interacts with multiple proteins. One interaction partner forms a complex with Importin-11 that is disassembled by Ran:GTP but not by Ran:GDP. ... | |
medium_divergent_branch_02395 | ARHGAP1 interacts with multiple genes. One interaction is supported by evidence stating: 'Using glutathione S-transferase recombinant proteins, immunoprecipitation studies, and yeast two-hybrid assays, it was found that a Bcl-2 homology domain-containing protein and Cdc42GAP could form homo and hetero complexes via the... | negative regulation of apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02395","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARHGAP1 interacts with multiple genes. One interaction is supported by evidence stating: 'Using glutathione S-transferase recombinant proteins, immun... | |
medium_divergent_branch_02397 | The gene IKZF1 interacts with multiple other genes. One of these interacting partners encodes a protein known as [REDACTED], which has been shown to interact with itself and the Ikaros protein via its C-terminal portion in a yeast two-hybrid assay. Which protein is encoded by this specific interacting partner gene? | Zinc finger protein Eos | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02397","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IKZF1 interacts with multiple other genes. One of these interacting partners encodes a protein known as [REDACTED], which has been shown to ... | |
medium_divergent_branch_02398 | TAP1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'At the same time TAP is arrested in a peptide transport incompetent conformation, although ATP and peptide binding to TAP are not affected.' Which molecular function, connecte... | transmembrane transporter activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02398","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAP1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'At t... | |
medium_divergent_branch_02399 | The gene TROAP interacts with multiple partners. One specific interaction is supported by evidence stating: 'Direct protein-protein interactions of trophinin, tastin, and bystin analyzed by yeast two-hybrid assays and by in vitro protein binding assays indicated that binding between bystin and trophinin and between bys... | ectopic pregnancy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02399","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TROAP interacts with multiple partners. One specific interaction is supported by evidence stating: 'Direct protein-protein interactions of t... | |
medium_divergent_branch_02400 | The gene TBX4 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating: 'The present identification of heterozygous TBX4 mutations in SPS patients, together with the similar skeletal phenotype of animals lacking TBX4, establish the im... | animal organ morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02400","source_qa_id":"medium_divergent_branch_06577","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene TBX4 is associated with multiple biological processes via the 'involved in' relationship... | |
medium_divergent_branch_02401 | MRAS interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation studies confirmed the interaction of M-Ras-GTP with a guanine nucleotide exchange factor in vivo.' Which protein corresponds to this specific interaction evidence? | Rap guanine nucleotide exchange factor 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02401","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MRAS interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation studies confirmed the interaction of... | |
medium_divergent_branch_02402 | The protein ARMC9 is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence stating: 'We show that ARMC9 localizes to the basal body of the cilium and is upregulated during ciliogenesis.' Which cellular component, connected to the component identif... | microtubule organizing center | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02402","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein ARMC9 is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence s... | |
medium_divergent_branch_02403 | The BCR protein interacts with multiple partners. One specific interaction partner is a Ras guanine nucleotide releasing protein that associates with Grb2 through Grb2's SH3 domains. Which protein is encoded by the gene corresponding to this interaction partner? | Son of sevenless homolog 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02403","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The BCR protein interacts with multiple partners. One specific interaction partner is a Ras guanine nucleotide releasing protein that associates with... | |
medium_divergent_branch_02406 | The manual digit phalanx endochondral element is a part of two distinct anatomical structures. One of these structures is defined by evidence citing 'A manual digit phalanx bone or its cartilage or pre-cartilage precursor.' Which of these two structures is the correct parent entity for the manual digit phalanx endochon... | individual digit of digitopodial skeleton | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02406","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The manual digit phalanx endochondral element is a part of two distinct anatomical structures. One of these structures is defined by evidence citing ... | |
medium_divergent_branch_02407 | RNF41 interacts with multiple proteins. One specific interaction is characterized by the mechanism where RNF41 induces K27- and K63-linked noncanonical polyubiquitination of the interacting partner to enhance its stability and induce actin remodeling, thereby promoting prostate cancer bone metastasis. Which protein cor... | Unconventional myosin-Ic | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02407","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF41 interacts with multiple proteins. One specific interaction is characterized by the mechanism where RNF41 induces K27- and K63-linked noncanonic... | |
medium_divergent_branch_02408 | CUL3 forms complexes with multiple adaptor proteins. One specific interaction is characterized by structural studies that determined the crystal structures of the BTB-BACK domains of the adaptor protein both alone and in complex with CUL3, alongside Kelch domain structures of KLHL2 (Mayven), KLHL7, another related prot... | LNX1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02408","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CUL3 forms complexes with multiple adaptor proteins. One specific interaction is characterized by structural studies that determined the crystal stru... | |
medium_divergent_branch_02409 | BCL2 is known to interact with multiple proteins. One specific interaction involves an orphan nuclear receptor also known as a specific member of the NR4A subfamily, which is required for cancer cell apoptosis induced by many antineoplastic agents. Which protein is encoded by the gene corresponding to this specific int... | Nuclear receptor subfamily 4immunitygroup A member 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02409","source_qa_id":"medium_divergent_branch_02720","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"BCL2 is known to interact with multiple proteins. One specific interaction involves an orphan nuc... | |
medium_divergent_branch_02415 | PRKCZ interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified the multifunctional chaperon protein [protein] as a protein kinase C (PKC)-binding protein interacting with PKCalpha, PKCzeta, PKCdelta, and PKC mu.' Which protein, connected to PRKCZ via this specific interaction e... | Complement component 1 Q subcomponent-binding protein, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02415","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKCZ interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified the multifunctional chaperon protein [protei... | |
medium_divergent_branch_02416 | GEMIN5 interacts with multiple genes. One of these interacting partners has been shown to physically interact with ASK1, MAP2K4, and JNK1, and to potentiate the H2O2-induced activation of these kinases in intact cells. Which disease is associated with this specific interacting partner via a biomarker relationship? | rheumatoid arthritis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02416","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GEMIN5 interacts with multiple genes. One of these interacting partners has been shown to physically interact with ASK1, MAP2K4, and JNK1, and to pot... | |
medium_divergent_branch_02417 | The gene NR1H3 (LXRalpha) interacts with multiple proteins. One specific interaction occurs in the absence of ligand, where LXRalpha associates with an ubiquitin E3-ligase protein complex containing a protein associated with breast and ovarian cancer susceptibility 1 (BRCA1). Which protein is encoded by the gene corres... | BRCA1-associated RING domain protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02417","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NR1H3 (LXRalpha) interacts with multiple proteins. One specific interaction occurs in the absence of ligand, where LXRalpha associates with ... | |
medium_divergent_branch_02418 | MYO10 interacts with multiple genes. One of these interacting partners is characterized by the finding that the FERM domain of MYO10 is required for its localization and accumulation at filopodia tips. Which disease is associated with this specific interacting gene as a biomarker? | monoclonal gammopathy of uncertain significance | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02418","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYO10 interacts with multiple genes. One of these interacting partners is characterized by the finding that the FERM domain of MYO10 is required for ... | |
medium_divergent_branch_02419 | CADM1 interacts with multiple genes. One of these interaction partners is described as a human homologue of the Drosophila tumor suppressor gene Discs large (Dlg), with evidence reporting that TSLC1 directly associates with it. Which disease is connected to this specific gene through a biomarker relationship? | leukopenia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02419","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CADM1 interacts with multiple genes. One of these interaction partners is described as a human homologue of the Drosophila tumor suppressor gene Disc... | |
medium_divergent_branch_02422 | The gene STX1A is known to interact with multiple protein partners. One specific interaction is supported by evidence stating: 'In the present study, we demonstrate by three independent methods that the C terminus of Munc13-1 interacts directly with a putative coiled coil domain in the N-terminal part of syntaxin.' Ide... | Protein unc-13 homolog B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02422","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene STX1A is known to interact with multiple protein partners. One specific interaction is supported by evidence stating: 'In the present study,... | |
medium_divergent_branch_02423 | PHLPP1 interacts with multiple proteins. One of these interacting partners has been shown to bind to PHLPP and directly remove polyubiquitin chains from it in both in vitro and cellular assays. Which protein is encoded by the gene corresponding to this specific interacting partner? | Ubiquitin carboxyl-terminal hydrolase 46 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02423","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PHLPP1 interacts with multiple proteins. One of these interacting partners has been shown to bind to PHLPP and directly remove polyubiquitin chains f... | |
medium_divergent_branch_02424 | Phospholipase D1 (PLD1) interacts with several proteins. One specific interaction is described by the following evidence: 'In a recombinant system, however, ADP-ribosylated Rho bound to effector proteins such as phospholipase D-1, Rho-kinase (ROK), and rhotekin.' Based on this description, which protein partner of PLD1... | Transforming protein RhoA | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02424","source_qa_id":"medium_divergent_branch_05183","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Phospholipase D1 (PLD1) interacts with several proteins. One specific interaction is described by... | |
medium_divergent_branch_02425 | MIR15B is associated with multiple biological processes. One specific association is supported by evidence that miR-15b inhibits trophoblast cell invasion and endothelial cell tube formation by suppressing the expression of Argonaute 2 (AGO2). Which biological process is negatively regulated by the process linked to th... | angiogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02425","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR15B is associated with multiple biological processes. One specific association is supported by evidence that miR-15b inhibits trophoblast cell inv... | |
medium_divergent_branch_02426 | GGA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report that the Vps10p domain receptor [protein encoded by SORL1] binds the adaptor proteins GGA1 and -2, which take part in Golgi-endosome sorting.' Which protein, connected to GGA2 via an interaction, is encoded by the gene m... | Sortilin-related receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02426","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GGA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report that the Vps10p domain receptor [protein encoded ... | |
medium_divergent_branch_02428 | WWC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Finally we found that KIBRA interacts with histone H3 via its glutamic acid-rich region and that such interaction might play a mechanistic role in conferring an optimal ER transactivation function as well as the proliferation of l... | Histone H3.1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02428","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WWC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Finally we found that KIBRA interacts with histone H3 via i... | |
medium_divergent_branch_02430 | ATOH7 (also known as Math5) is a bHLH transcription factor required for retinal ganglion cell (RGC) development and the development of a specific anatomical structure. This gene is involved in a biological process that results in the development of that structure. Which anatomical structure is connected to this biologi... | cranial nerve II | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02430","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATOH7 (also known as Math5) is a bHLH transcription factor required for retinal ganglion cell (RGC) development and the development of a specific ana... | |
medium_divergent_branch_02431 | VEGFA is associated with multiple molecular functions via the 'enables' relationship. One specific connection is supported by evidence stating: 'Similar to VEGF-A, gremlin activates VEGFR2 in endothelial cells, leading to VEGFR2-dependent angiogenic responses in vitro and in vivo.' Which molecular function, connected t... | vascular endothelial growth factor receptor binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02431","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VEGFA is associated with multiple molecular functions via the 'enables' relationship. One specific connection is supported by evidence stating: 'Simi... | |
medium_divergent_branch_02432 | CRKL interacts with multiple genes. One of these interaction partners is characterized by evidence stating that anti-Crkl immunoprecipitations demonstrate the ITAM-containing gamma subunit of Fc gamma RI is induced to form a complex with the Crkl protein, and that Crkl binds to the cytoskeletal protein Hef-1. Which dis... | Hodgkins lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02432","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CRKL interacts with multiple genes. One of these interaction partners is characterized by evidence stating that anti-Crkl immunoprecipitations demons... | |
medium_divergent_branch_02433 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.453 and an adjusted p-value of 0.0452. Which disease has a genomic-alteration link with that selected gene? | lung cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02433","source_qa_id":"medium_divergent_branch_05917","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_02434 | MIR29A is associated with multiple biological processes. One association is supported by evidence that exogenous agomiR-29a promotes, while Antagomir-29a represses, the proliferation and tube formation of HUVECs. Which biological process, connected to MIR29A via this specific evidence, is the target of a 'positively re... | vascular endothelial cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02434","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR29A is associated with multiple biological processes. One association is supported by evidence that exogenous agomiR-29a promotes, while Antagomir... | |
medium_divergent_branch_02435 | CENPV interacts with multiple proteins. One interaction is characterized by the proline-rich region of human CENP-V associating with the SH3 domains of Src family kinases (SFKs) and potently activating them. Which protein is encoded by the gene corresponding to this specific interacting partner? | Tyrosine-protein kinase Lyn | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02435","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CENPV interacts with multiple proteins. One interaction is characterized by the proline-rich region of human CENP-V associating with the SH3 domains ... | |
medium_divergent_branch_02436 | IL1R2 is associated with multiple biological processes. One association is supported by evidence stating: 'The latter include decoy receptors (IL-1RII; IL-18BP) and "receptors" with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR).' Identify the biological process connected to this specific IL1R2-associated process... | inflammatory response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02436","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL1R2 is associated with multiple biological processes. One association is supported by evidence stating: 'The latter include decoy receptors (IL-1RI... | |
medium_divergent_branch_02437 | EDARADD interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that endogenous and overexpressed [protein], [protein] and TAK1 co-immunoprecipitated with Edaradd in 293 cells.' Which protein, connected to EDARADD via an interaction, is encoded by the gene in question? | TNF receptor-associated factor 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02437","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EDARADD interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that endogenous and overexpressed [protein... | |
medium_divergent_branch_02438 | The protein FTH1P21 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 10.33 TPM, a z-score of 1.63, and a fold enrichment of 3.11. Which cell type corresponds to this specific expression profile, and what is its direct parent category in the cell type hierarch... | monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02438","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein FTH1P21 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 10.33 TPM, a z-scor... | |
medium_divergent_branch_02439 | The protein CR1 is associated with multiple biological processes. One specific association is supported by evidence stating that ATP release following CR1 ligation increases the mobility of the lipid fraction of red blood cell (RBC) membranes, facilitating CR1 clustering and enhancing the binding avidity of complement-... | membrane organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02439","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CR1 is associated with multiple biological processes. One specific association is supported by evidence stating that ATP release followin... | |
medium_divergent_branch_02440 | VPS25 interacts with multiple genes. Evidence for one of these interactions describes a complex with three lobes containing one copy each of VPS22 and the interacting partner, and two copies of VPS25. Which disease is associated with this interacting partner? | lipoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02440","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VPS25 interacts with multiple genes. Evidence for one of these interactions describes a complex with three lobes containing one copy each of VPS22 an... | |
medium_divergent_branch_02441 | RFWD2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Investigation of the underlying mechanism suggests that COP1 S387 phosphorylation is required for COP1 to bind 14-3-3σ.' Which protein, connected to RFWD2 via an interaction, is encoded by the gene associated with this specific e... | 14-3-3 protein zeta/delta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02441","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RFWD2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Investigation of the underlying mechanism suggests that CO... | |
medium_divergent_branch_02442 | AP2A2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Immunoblot analysis with anti-alpha-adaptin antibody revealed that alpha-adaptin was coimmunoprecipitated with a specific adaptor protein from PC12, KB, and COS cell lysates, suggesting a specific interaction of this adapto... | malignant pancreatic neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02442","source_qa_id":"medium_divergent_branch_01984","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"AP2A2 interacts with multiple genes. One specific interaction is supported by evidence stating: '... | |
medium_divergent_branch_02443 | FGF7 is associated with multiple biological processes via the 'involved in' relationship. One piece of evidence states: 'We next demonstrated that FGF7 and FGF10 were able to induce the proliferation of the epithelial cells in vitro.' Which biological process, connected to the process supported by this evidence, is lin... | epithelial cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02443","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF7 is associated with multiple biological processes via the 'involved in' relationship. One piece of evidence states: 'We next demonstrated that FG... | |
medium_divergent_branch_02444 | MAP3K7 interacts with multiple genes. One of these interacting partners is described in a study where, in response to a high-fat diet (HFD), hepatocyte expression of this partner leads to binding with TGF-β-activated kinase 1 (TAK1). This interaction induces TAK1 ubiquitination and autophosphorylation, enhancing downst... | plasma cell myeloma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02444","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K7 interacts with multiple genes. One of these interacting partners is described in a study where, in response to a high-fat diet (HFD), hepatocy... | |
medium_divergent_branch_02445 | GIGYF1 interacts with multiple genes. One of these interacting partners is described as harboring three proline-rich motifs that bind the GYF domain of GIGYF1, a feature noted as being similar to a paralog. Which disease is associated with this specific interacting gene via a biomarker relationship? | adult lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02445","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GIGYF1 interacts with multiple genes. One of these interacting partners is described as harboring three proline-rich motifs that bind the GYF domain ... | |
medium_divergent_branch_02446 | GATA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Glutathione-S-transferase interaction studies showed that MED220 or GATA-2 each bound the homeodomain of Pit-1, whereas MED220 interacted independently with each zinc finger of GATA-2 but not with either terminus.' Which protein,... | Mediator of RNA polymerase II transcription subunit 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02446","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Glutathione-S-transferase interaction studies showed that ... | |
medium_divergent_branch_02447 | ING4 interacts with multiple proteins. One interaction is supported by evidence stating: 'The family of proteins inhibitors of growth (ING) contains a PHD finger that bind to histone-3 trimethylated at lysine 4, and those of ING1 and ING2 also act as nuclear phosphoinositide receptors.' Which protein, connected to ING4... | Histone H3.1t | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02447","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ING4 interacts with multiple proteins. One interaction is supported by evidence stating: 'The family of proteins inhibitors of growth (ING) contains ... | |
medium_divergent_branch_02448 | The humerus cartilage element is classified as a type of anatomy. One such classification describes the entity as a humerus endochondral element composed primarily of cartilage tissue. Which anatomical structure is this specific entity a part of? | forelimb stylopod | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02448","source_qa_id":"medium_divergent_branch_07331","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The humerus cartilage element is classified as a type of anatomy. One such classification describ... | |
medium_divergent_branch_02449 | GPSM1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Each GPR motif binds to the alpha subunit of Gi/Go (Gialpha > Goalpha) stabilizing the GDP-bound conformation of Galpha and apparently competing with Gbetagamma for GalphaGDP binding.' Which protein, connected to GPSM1 via this s... | Guanine nucleotide-binding protein G(i) subunit alpha-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02449","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GPSM1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Each GPR motif binds to the alpha subunit of Gi/Go (Gialph... | |
medium_divergent_branch_02450 | COPG1 interacts with multiple genes. One of these interaction partners was identified in a study that reported, for the first time, members of the coatomer I (COPI) complex as interaction partners of hSAC1. Which biological process is the gene identified in this specific study involved in? | phosphatidylinositol dephosphorylation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02450","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COPG1 interacts with multiple genes. One of these interaction partners was identified in a study that reported, for the first time, members of the co... | |
medium_divergent_branch_02451 | SRSF6 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by the following evidence: 'Here, we identify the splicing factor SRSF6 as a regulator of wound healing and tissue homeostasis in skin.' Based on this evidence, which biological process is th... | regulation of response to wounding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02451","source_qa_id":"medium_divergent_branch_03831","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SRSF6 is associated with multiple biological processes via the 'involved in' relationship. One sp... | |
medium_divergent_branch_02452 | West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.100 and an adjusted p-value of 0.0226. Which disease is associated with that selected gene? | thrombocytopenia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02452","source_qa_id":"medium_divergent_branch_04672","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log... | |
medium_divergent_branch_02453 | S100A9 is associated with multiple biological processes. One association is supported by evidence stating that 'these studies ... strongly suggest that these proteins are involved in neutrophil migration to inflammatory sites.' Identify the biological process linked to this specific association via an 'is a' relationsh... | leukocyte migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02453","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"S100A9 is associated with multiple biological processes. One association is supported by evidence stating that 'these studies ... strongly suggest th... | |
medium_divergent_branch_02455 | The gene DLD interacts with multiple partners. One specific interaction is supported by evidence stating: 'Moreover, a high affinity interaction has been demonstrated between the homodimeric E1 and E3 components, which form a stable subcomplex comprising single copies of these two enzymes.' Which protein is encoded by ... | 2-oxoglutarate dehydrogenase complex component E1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02455","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DLD interacts with multiple partners. One specific interaction is supported by evidence stating: 'Moreover, a high affinity interaction has ... | |
medium_divergent_branch_02457 | WNK3 is associated with multiple biological processes. One association is supported by evidence showing that coexpression of WNK3 leads to an 82.7 +/- 7.1% increase in TRPV5-mediated Ca2+ uptake. Which broader biological process is a parent term (via 'is a') of the specific process linked to this calcium uptake evidenc... | regulation of calcium ion transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02457","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNK3 is associated with multiple biological processes. One association is supported by evidence showing that coexpression of WNK3 leads to an 82.7 +/... | |
medium_divergent_branch_02458 | PES1 interacts with multiple proteins. One specific interaction is supported by evidence showing that mutant M1 and M5 proteins associate with large pre-ribosomal complexes and co-immunoprecipitate with Bop1 and the target protein, indicating their proper incorporation into the PeBoW complex. Which protein is encoded b... | Ribosome biogenesis protein WDR12 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02458","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PES1 interacts with multiple proteins. One specific interaction is supported by evidence showing that mutant M1 and M5 proteins associate with large ... | |
medium_divergent_branch_02459 | ATG9A interacts with multiple proteins. One specific interaction involves mAtg9 binding to adaptor protein-1 (AP1) and the cation-independent mannose-6-phosphate receptor, a process that facilitates AP1 polymerization and the transport of cathepsin D from the trans-Golgi network. Which protein, encoded by the gene invo... | AP-1 complex subunit mu-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02459","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATG9A interacts with multiple proteins. One specific interaction involves mAtg9 binding to adaptor protein-1 (AP1) and the cation-independent mannose... | |
medium_divergent_branch_02460 | MIR146A is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'Of all identified miRNAs, miR-146a-5p was one of the most significantly changed miRNAs with high expression in exosomes from T. pallidum-stimulated macrophages.' Which c... | extracellular vesicle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02460","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR146A is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating:... | |
medium_divergent_branch_02461 | The gene GCNT4 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 15.49 TPM, a z-score of 1.65, and a fold enrichment of 4.71. Which cell type corresponds to this specific expression profile, and what is its immediate parent category in the cell type... | mature T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02461","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene GCNT4 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 15.49 TPM, a ... | |
medium_divergent_branch_02462 | MKI67 interacts with multiple proteins. One specific interaction was identified using a two-hybrid screening in yeast, where a novel protein was shown to interact with the forkhead-associated (FHA) domain of pKi-67. Which disease is linked to this specific interacting protein by the relation 'biomarker'? | urinary bladder neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02462","source_qa_id":"medium_divergent_branch_05351","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MKI67 interacts with multiple proteins. One specific interaction was identified using a two-hybri... | |
medium_divergent_branch_02463 | PRMT5 is associated with multiple cellular components. One association is supported by evidence stating that Protein arginine methyltransferase 5 targets nuclear and cytoplasmic proteins. Which cell type is connected to the cellular component implied by this specific evidence through a 'part of cell' relationship? | erythroblast | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02463","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRMT5 is associated with multiple cellular components. One association is supported by evidence stating that Protein arginine methyltransferase 5 tar... | |
medium_divergent_branch_02465 | PRKDC interacts with multiple proteins. One interaction is characterized by the following evidence: 'The DNA-dependent protein kinase (DNA-PK) controls the repair of double-stranded DNA breaks in mammalian cells. The protein kinase subunit of DNA-PK (DNA-PKcs) is targeted to DNA breaks by association with the Ku DNA-bi... | male infertility | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02465","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKDC interacts with multiple proteins. One interaction is characterized by the following evidence: 'The DNA-dependent protein kinase (DNA-PK) contro... | |
medium_divergent_branch_02466 | HIPK2 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we identify the homeodomain-interacting protein kinase 2 (HIPK2) as a kinase that binds the target protein and phosphorylates it at Ser 80 in vitro and in vivo.' Which disease is causally linked to the gene identified in this ... | hypogonadism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02466","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIPK2 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we identify the homeodomain-interacting protein kinase ... | |
medium_divergent_branch_02468 | VPS28 interacts with multiple proteins. One specific interaction involves ESCRT-II binding to the C-terminal domain of the ESCRT-I subunit VPS28 via a helix located immediately C-terminal to the GLUE domain of the interacting partner. Which protein, encoded by the gene connected to VPS28 through this specific binding i... | Vacuolar protein-sorting-associated protein 36 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02468","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VPS28 interacts with multiple proteins. One specific interaction involves ESCRT-II binding to the C-terminal domain of the ESCRT-I subunit VPS28 via ... | |
medium_divergent_branch_02469 | PRKCA interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation studies using tsA201 cells reveal that a specific protein and PKC associate with each other in cells.' Which protein, connected to PRKCA via this specific interaction evidence, is the subject of the 'encode... | E3 ubiquitin-protein ligase TRIM41 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02469","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKCA interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation studies using tsA201 cells reveal t... | |
medium_divergent_branch_02470 | BNIP1 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stating: 'This modification promotes BNip1 transportation to mitochondria but has no influence on its protein level.' Which cellular component is connected to the BNIP1-associated ... | mitochondrial envelope | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02470","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BNIP1 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stating: ... | |
medium_divergent_branch_02471 | TBC1D10A interacts with multiple proteins. One of these interaction partners is described in literature as a 64- or 65-kD differentially phosphorylated polypeptide that binds preferentially to the first PDZ domain of a specific PDZ-domain-containing scaffolding protein and to E3KARP, and is referred to as EPI64. Which ... | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02471","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TBC1D10A interacts with multiple proteins. One of these interaction partners is described in literature as a 64- or 65-kD differentially phosphorylat... | |
medium_divergent_branch_02472 | RTN4 interacts with multiple genes. One of these interaction partners is supported by evidence showing that RTN-XS interacts with both a Bcl-2 family member and Bcl-2, increases their localization to the endoplasmic reticulum, and reduces their anti-apoptotic activity. Which cell type is enriched in the gene correspond... | gamma-delta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02472","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RTN4 interacts with multiple genes. One of these interaction partners is supported by evidence showing that RTN-XS interacts with both a Bcl-2 family... | |
medium_divergent_branch_02473 | GRK2 is involved in multiple biological processes. One of these processes is supported by evidence stating: 'we demonstrated that GRK2 plays a crucial role in GPR161 export.' Which biological process is negatively regulated by this specific GRK2-associated process? | protein localization to ciliary membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02473","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GRK2 is involved in multiple biological processes. One of these processes is supported by evidence stating: 'we demonstrated that GRK2 plays a crucia... | |
medium_divergent_branch_02474 | CXCR2 is associated with multiple biological processes. One association is supported by evidence stating: 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).' Identify the b... | granulocyte activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02474","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CXCR2 is associated with multiple biological processes. One association is supported by evidence stating: 'The G protein-coupled CXC-chemokine recept... | |
medium_divergent_branch_02475 | VAPB interacts with multiple proteins. One specific interaction is supported by evidence stating that 'hVAP-A and hVAP-B associated with each other through their respective TMDs.' Which protein corresponds to this interaction partner? | Vesicle-associated membrane protein-associated protein A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02475","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VAPB interacts with multiple proteins. One specific interaction is supported by evidence stating that 'hVAP-A and hVAP-B associated with each other t... | |
medium_divergent_branch_02476 | ING5 interacts with multiple proteins. One specific interaction involves a complex where the enhancer of polycomb (EPc) homology domain in the middle part binds to ING5 and a partner protein. Which protein, connected to ING5 through this specific binding evidence, is encoded by the gene in question? | Chromatin modification-related protein MEAF6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02476","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ING5 interacts with multiple proteins. One specific interaction involves a complex where the enhancer of polycomb (EPc) homology domain in the middle... | |
medium_divergent_branch_02477 | The gene ITK interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we report a TCR/CD3-regulated association between Emt and PLC gamma 1 in both normal and leukemic T cells.' Which protein, encoded by the gene connected to ITK via this specific interaction, is the subject of... | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02477","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ITK interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we report a TCR/CD3-regulated associa... | |
medium_divergent_branch_02478 | ZNF703 is associated with multiple biological processes. One association is supported by evidence that overexpression of ZNF703 in normal human breast epithelial cells enhanced the frequency of in vitro colony-forming cells from luminal progenitors. Which biological process, connected to the process supported by this e... | epithelial cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02478","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZNF703 is associated with multiple biological processes. One association is supported by evidence that overexpression of ZNF703 in normal human breas... | |
medium_divergent_branch_02479 | The NBN gene interacts with multiple partners. One specific interaction is supported by evidence stating that mutations in the nibrin FHA and BRCT domains did not affect the interaction with Mre11 or the nuclear localization of the complex. Which cell type is enriched for the gene corresponding to this specific interac... | natural killer cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02479","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The NBN gene interacts with multiple partners. One specific interaction is supported by evidence stating that mutations in the nibrin FHA and BRCT do... | |
medium_divergent_branch_02480 | CXCR1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Recent evidence indicates that a direct physical association occurs between IL-8 receptors and the alpha subunit of guanine nucleotide regulatory protein (Gi(alpha)2) upon stimulation of human neutrophils by IL-8.' Which protein ... | Guanine nucleotide-binding protein G(i) subunit alpha-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02480","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CXCR1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Recent evidence indicates that a direct physical associati... | |
medium_divergent_branch_02481 | EIF4B interacts with multiple proteins. One interaction is supported by evidence stating: 'Affinity chromatography demonstrates that mammalian eIF4B interacts with the poly(A)-binding protein and that a region consisting of the N-terminal 80 amino acids of eIF4B is both necessary and sufficient for such binding.' Which... | Polyadenylate-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02481","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF4B interacts with multiple proteins. One interaction is supported by evidence stating: 'Affinity chromatography demonstrates that mammalian eIF4B ... | |
medium_divergent_branch_02482 | SNX27 interacts with multiple proteins. One specific interaction is characterized by the association of the C-terminal PDZ-binding motif (PDZbm) of the interacting partner with the cargo-binding site in the PDZ domain of SNX27. Which protein corresponds to this specific interaction partner? | Ubiquitin thioesterase otulin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02482","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SNX27 interacts with multiple proteins. One specific interaction is characterized by the association of the C-terminal PDZ-binding motif (PDZbm) of t... | |
medium_divergent_branch_02483 | The gene FLNB interacts with multiple partners. One specific interaction is supported by evidence stating: 'We report here that the loop regions of [Protein A] and [Protein B] interact with nonmuscle filamin (actin-binding protein 280, ABP280) and a structurally related protein (filamin homolog 1, Fh1).' Based on this ... | Presenilin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02483","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FLNB interacts with multiple partners. One specific interaction is supported by evidence stating: 'We report here that the loop regions of [... | |
medium_divergent_branch_02484 | Orthohepevirus A upregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of 1.239 and an adjusted p-value of 0.04818. Which disease is associated with this specific upregulated gene via a biomarker relationship? | colorectal carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02484","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Orthohepevirus A upregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of 1.239 and an adjusted p-value... | |
medium_divergent_branch_02485 | SETD1A interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunoprecipitation and mass spectrometry reveal that Set1B associates with a approximately 450 kDa complex that contains all five non-catalytic components of the Set1A complex, including CFP1, Rbbp5, Ash2, Wdr5, and the protein... | WD repeat-containing protein 82 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02485","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SETD1A interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunoprecipitation and mass spectrometry reveal that Set... | |
medium_divergent_branch_02486 | E2F6 is known to bind to multiple gene products. One specific interaction is supported by evidence stating: 'We showed that, both in vitro and in vivo, E2F6, DP1, and this partner form a stable core complex with repressive activity.' Based on this description, which gene product forms this complex with E2F6 and DP1, an... | HOPX | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02486","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"E2F6 is known to bind to multiple gene products. One specific interaction is supported by evidence stating: 'We showed that, both in vitro and in viv... | |
medium_divergent_branch_02487 | The biological process 'regulation of neuron maturation' is defined as any process that modulates the frequency, rate, or extent of neuron maturation, which is the process leading to the attainment of the full functional capacity of a neuron and is independent of morphogenetic change. This process is a subtype of anoth... | cell maturation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02487","source_qa_id":"medium_divergent_branch_04160","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of neuron maturation' is defined as any process that modulates... | |
medium_divergent_branch_02488 | PIN1 interacts with multiple proteins. One interaction partner is characterized by evidence showing that it associates with PIN1 following phosphorylation at Serine 194, a process induced by simultaneous IL-5 and anti-Fas treatment (which also modestly reduced peptidyl isomerase activity). Which protein is encoded by t... | FAS-associated death domain protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02488","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIN1 interacts with multiple proteins. One interaction partner is characterized by evidence showing that it associates with PIN1 following phosphoryl... | |
medium_divergent_branch_02489 | COPS5 interacts with multiple proteins. One interaction is supported by evidence describing the purification of the human CSN complex from a stable 293 cell line expressing N-terminal HBTH-tagged CSN5, achieved via high-affinity streptavidin binding and TEV cleavage elution. Which protein, connected to COPS5 through th... | COP9 signalosome complex subunit 8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02489","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COPS5 interacts with multiple proteins. One interaction is supported by evidence describing the purification of the human CSN complex from a stable 2... | |
medium_divergent_branch_02490 | EFEMP1 interacts with multiple genes. One of these interaction partners is part of a set of eight interactions (including ERdj5 and PDIA6) that were verified at the western blotting level. Which disease is associated with this specific interacting gene? | gastritis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02490","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EFEMP1 interacts with multiple genes. One of these interaction partners is part of a set of eight interactions (including ERdj5 and PDIA6) that were ... | |
medium_divergent_branch_02491 | The gene NR5A1 (encoding the transcription factor SF-1) interacts with multiple partner genes. One specific interaction is characterized by the binding of SF-1 to a coregulator protein via its activation function-2 (AF-2) domain. Which protein is encoded by the gene that corresponds to this specific interaction partner... | Nuclear receptor-interacting protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02491","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NR5A1 (encoding the transcription factor SF-1) interacts with multiple partner genes. One specific interaction is characterized by the bindi... | |
medium_divergent_branch_02492 | The gene CACNA1A interacts with multiple proteins. One specific interaction partner is characterized by evidence showing it binds to the CaM-binding domain, co-immunoprecipitates with the alpha12.1 subunit from transfected cells and brain extracts, and colocalizes with alpha12.1 in discrete microdomains of neurons in t... | Calcium-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02492","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CACNA1A interacts with multiple proteins. One specific interaction partner is characterized by evidence showing it binds to the CaM-binding ... | |
medium_divergent_branch_02493 | PDS5B interacts with multiple genes. One of these interaction partners is identified in a study reporting that APRIN interacts directly with RAD51, the partner gene, and BRCA2. Which biological process is this partner gene involved in? | double-strand break repair via homologous recombination | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02493","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDS5B interacts with multiple genes. One of these interaction partners is identified in a study reporting that APRIN interacts directly with RAD51, t... | |
medium_divergent_branch_02494 | SOX18 is associated with multiple biological processes. One association is supported by evidence that SOX18 mutations in humans cause hypotrichosis-lymphedema-telangiectasia, indicating that this transcription factor plays a role in the development and/or maintenance of lymphatic vessels, in addition to its established... | lymph vessel morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02494","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX18 is associated with multiple biological processes. One association is supported by evidence that SOX18 mutations in humans cause hypotrichosis-l... |
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