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medium_divergent_branch_02261 | GAK interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation and Western blotting showed that GAK and cyclin G associate together in vivo.' Which protein, encoded by the gene interacting with GAK in this specific context, is the subject of this evidence? | Cyclin-G1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02261","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GAK interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation and Western blotting showed that GAK ... | |
medium_divergent_branch_02262 | PFKL interacts with multiple genes. One of these interaction partners is known to interact with TNFAIP3, which promotes its degradation and thereby inhibits glycolysis in hepatocellular carcinoma (HCC) cell lines. Which disease is associated with this specific interaction partner via a biomarker relationship? | myocarditis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02262","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PFKL interacts with multiple genes. One of these interaction partners is known to interact with TNFAIP3, which promotes its degradation and thereby i... | |
medium_divergent_branch_02263 | LRG1 is associated with multiple biological processes. One association is supported by evidence stating: 'We show that in the presence of transforming growth factor-β1 (TGF-β1), LRG1 is mitogenic to endothelial cells and promotes angiogenesis.' Which cell type is linked to this specific biological process via the 'enab... | circulating fibrocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02263","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRG1 is associated with multiple biological processes. One association is supported by evidence stating: 'We show that in the presence of transformin... | |
medium_divergent_branch_02266 | HSF1 interacts with multiple proteins. One of these interaction partners is a bromodomain-containing ubiquitin ligase that is recruited to the promoter through interactions with HSF1 and a TIP60-mediated acetylation mark. Which protein corresponds to this interaction partner? | E3 ubiquitin-protein ligase TRIM33 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02266","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HSF1 interacts with multiple proteins. One of these interaction partners is a bromodomain-containing ubiquitin ligase that is recruited to the promot... | |
medium_divergent_branch_02267 | RND3 interacts with multiple proteins. One of these interaction partners is described in evidence stating that it physically interacts with NICD, CSL, and MAML1 (components of the Notch transcriptional complex), promotes NICD ubiquitination, and facilitates the degradation of these cofactor proteins. Which protein is e... | Neurogenic locus notch homolog protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02267","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RND3 interacts with multiple proteins. One of these interaction partners is described in evidence stating that it physically interacts with NICD, CSL... | |
medium_divergent_branch_02269 | TBP interacts with multiple proteins. One of these interacting partners binds to TBP through both its N- and C-terminal regions, and both regions are essential for the partner's ability to inhibit p53-mediated transactivation. Which protein is encoded by the gene corresponding to this specific interacting partner? | Zinc finger protein 76 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02269","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TBP interacts with multiple proteins. One of these interacting partners binds to TBP through both its N- and C-terminal regions, and both regions are... | |
medium_divergent_branch_02270 | The protein EEF1A1 is associated with multiple cellular components via 'located_in' relationships. One specific association is supported by evidence stating: 'We discovered that the elongation factor-1α (eEF1A) inhibitor, ternatin-4, triggers the ubiquitination and degradation of eEF1A on stalled ribosomes.' Based on t... | ribosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02270","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein EEF1A1 is associated with multiple cellular components via 'located_in' relationships. One specific association is supported by evidence ... | |
medium_divergent_branch_02271 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 2.690 and an adjusted p-value of 0.000912. Which disease is associated with that selected gene? | pulmonary emphysema | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02271","source_qa_id":"medium_divergent_branch_00896","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_02272 | SMAD4 interacts with multiple proteins. One such interaction is supported by evidence stating: 'Moreover, we demonstrate that the interaction partner plays a role in the Smad-mediated signal transduction pathway, interacting with the common mediator, Smad4, in a ligand-dependent fashion.' Which disease is associated wi... | hypertensive disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02272","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD4 interacts with multiple proteins. One such interaction is supported by evidence stating: 'Moreover, we demonstrate that the interaction partner... | |
medium_divergent_branch_02273 | Langerhans cells are anatomically associated with multiple structures via a 'part of' relationship. One such association is supported by the following description: 'The layer of polyhedral cells in the epidermis found between the stratum granulosum and stratum basale; shrinkage and adhesion of these cells gives a spiny... | skin epidermis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02273","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Langerhans cells are anatomically associated with multiple structures via a 'part of' relationship. One such association is supported by the followin... | |
medium_divergent_branch_02274 | Human gammaherpesvirus 4 is reported to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of approximately -1.97 and an adjusted p-value of approximately 0.0386. Which protein is encoded by the gene corresponding to this specific downregulation event? | Arylsulfatase J | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02274","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human gammaherpesvirus 4 is reported to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of appr... | |
medium_divergent_branch_02275 | TET2 is associated with multiple biological processes. One association is supported by evidence showing that shRNA-mediated depletion of TET2 in mouse haematopoietic precursors skewed their differentiation towards monocyte/macrophage lineages in culture. Which cell type is the final result of the biological process lin... | myeloid cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02275","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TET2 is associated with multiple biological processes. One association is supported by evidence showing that shRNA-mediated depletion of TET2 in mous... | |
medium_divergent_branch_02276 | CRIPTO is associated with multiple biological processes. One specific association is supported by evidence describing a role in potentiating branching morphogenesis and modulating differentiation in the developing mammary gland. Which biological process, connected to the process supported by this evidence via an 'is a'... | cellular developmental process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02276","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CRIPTO is associated with multiple biological processes. One specific association is supported by evidence describing a role in potentiating branchin... | |
medium_divergent_branch_02277 | CLASP2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Using biochemical, molecular modeling and cell biological analyses, we have investigated the interactions between the TOG domains and αβ-tubulin and found that each domain a... | tubulin binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02277","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLASP2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Us... | |
medium_divergent_branch_02278 | RNF25 interacts with multiple genes. One interaction is supported by evidence stating: 'Unlike most RINGs, AO7 (RNF25) binds the E2 ubiquitin-conjugating enzyme, [E2 ubiquitin-conjugating enzyme], with strikingly high affinity.' Which protein is encoded by the gene that interacts with RNF25 in this specific context? | Ubiquitin-conjugating enzyme E2 D2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02278","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF25 interacts with multiple genes. One interaction is supported by evidence stating: 'Unlike most RINGs, AO7 (RNF25) binds the E2 ubiquitin-conjuga... | |
medium_divergent_branch_02280 | The IgD immunoglobulin complex is associated with multiple cell types via the plasma membrane. One such cell type is a mature B cell subset originally defined as CD45R-positive, IgM-positive, IgD-positive, and CD43-negative. Subsequent research characterized this subset as CD21-positive, CD23-negative, and CD93-negativ... | fraction E immature B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02280","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The IgD immunoglobulin complex is associated with multiple cell types via the plasma membrane. One such cell type is a mature B cell subset originall... | |
medium_divergent_branch_02281 | TAF10 interacts with multiple genes. One of these interacting partners is an enzyme whose substrate specificity was investigated by solving its structure bound to a TAF10 peptide and examining its ability to methylate histone H3, TAF10, and p53. Which disease is associated with this specific interacting partner? | infectious mononucleosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02281","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAF10 interacts with multiple genes. One of these interacting partners is an enzyme whose substrate specificity was investigated by solving its struc... | |
medium_divergent_branch_02282 | ARL2 interacts with multiple proteins. One interaction partner is described as follows: 'The ADP-ribosylation factor-like 2 (ARL2) GTPase and its binding partner [ARL2-binding protein] are ubiquitously expressed in rodent and human tissues and are most abundant in brain.' Which disease is associated with this specific ... | ductal breast carcinoma in situ | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02282","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARL2 interacts with multiple proteins. One interaction partner is described as follows: 'The ADP-ribosylation factor-like 2 (ARL2) GTPase and its bin... | |
medium_divergent_branch_02284 | RIMS1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have recently isolated a novel cytomatrix at the active zone (CAZ)-associated protein, [CAZ-associated protein], and found it directly binds another CAZ protein RIM1 and indirectly binds Munc13-1 through RIM1; RIM1 and Munc13-... | ERC protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02284","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RIMS1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have recently isolated a novel cytomatrix at the active... | |
medium_divergent_branch_02285 | RNASEH2A is known to interact with multiple proteins. One specific interaction is described by the following evidence: 'We also show that this protein directly interacts with RNase H2, mediates its localization to DSBs in the S/G2 cell-cycle phase, and controls DNA:RNA hybrid levels at DSBs.' Which protein is encoded b... | Breast cancer type 2 susceptibility protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02285","source_qa_id":"medium_divergent_branch_01152","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"RNASEH2A is known to interact with multiple proteins. One specific interaction is described by th... | |
medium_divergent_branch_02286 | TNFRSF1A interacts with multiple proteins. One interaction partner is described in a study stating: 'We show that MDC does not prevent the interaction of the p55 TNF receptor (TR55) with FAN and this protein.' Which cell type is enriched for the gene corresponding to this protein? | CD4-positive, alpha-beta memory T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02286","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNFRSF1A interacts with multiple proteins. One interaction partner is described in a study stating: 'We show that MDC does not prevent the interactio... | |
medium_divergent_branch_02287 | GNB5 is known to bind multiple partners. One specific interaction is described by the statement: 'All members of the R7 RGS form trimeric complexes with the atypical G protein β subunit, Gβ5, and membrane anchor R7BP or R9AP.' Based on this description, identify the gene that forms this complex with GNB5. Then, determi... | ACTN2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02287","source_qa_id":"medium_divergent_branch_03758","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GNB5 is known to bind multiple partners. One specific interaction is described by the statement: ... | |
medium_divergent_branch_02292 | The gene ACTL10 is enriched in multiple cell types. One specific cell type shows a mean expression of 4.08 TPM, a z-score of 2.00, and a fold enrichment of 3.68. Which cell type, defined by these statistics, is a subtype of mature T cells? | mature T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02292","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ACTL10 is enriched in multiple cell types. One specific cell type shows a mean expression of 4.08 TPM, a z-score of 2.00, and a fold enrichm... | |
medium_divergent_branch_02293 | Dendritic cells are found in multiple anatomical locations. One such location is described as a dense region demarcating the thymus medulla from the surrounding cortex, characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendrit... | anatomical junction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02293","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Dendritic cells are found in multiple anatomical locations. One such location is described as a dense region demarcating the thymus medulla from the ... | |
medium_divergent_branch_02294 | RARA interacts with multiple proteins. One of these interactions is supported by evidence from coimmunoprecipitation studies, glutathione S-transferase pull-down experiments, and mammalian two-hybrid assays, which suggest a physical interaction between RAR/RXR and the target protein. Which protein is encoded by the gen... | Transcription factor Sp1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02294","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RARA interacts with multiple proteins. One of these interactions is supported by evidence from coimmunoprecipitation studies, glutathione S-transfera... | |
medium_divergent_branch_02296 | hsa-miR-17-5p regulates more than one cell type. One line of evidence indicates that the miR-17-92 cluster facilitates the secretion of CXCL9 and CXCL10 from keratinocytes by inhibiting SOCS1, thereby enhancing chemotaxis for T lymphocytes. Which cell type, connected to hsa-miR-17-5p via a 'regulates' relationship, is ... | pro-T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02296","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-17-5p regulates more than one cell type. One line of evidence indicates that the miR-17-92 cluster facilitates the secretion of CXCL9 and CXC... | |
medium_divergent_branch_02298 | EEF1G interacts with multiple genes. One interaction is supported by evidence stating: 'Among the 80 tested pairs, leucyl- and histidyl-tRNA synthetases were found to make strong and specific interaction with the EF-1gamma and beta while glu-proly-, glutaminyl-, alanyl-, aspartyl-, lysyl-, phenylalanyl-, glycyl-, and t... | ovarian neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02298","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EEF1G interacts with multiple genes. One interaction is supported by evidence stating: 'Among the 80 tested pairs, leucyl- and histidyl-tRNA syntheta... | |
medium_divergent_branch_02300 | CRADD interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that activation of caspase-2 occurs in a complex that contains the death domain-containing protein [protein A], whose expression is induced by p53, and the adaptor protein RAIDD.' Which protein, connected to CRADD via thi... | p53-induced death domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02300","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CRADD interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that activation of caspase-2 occurs in a complex t... | |
medium_divergent_branch_02301 | The esophagus is classified as a type of anatomy. One classification path describes it as a tube connecting the pharynx to the stomach, noting that in mammals, it connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity continues through the pharynx into t... | digestive tract | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02301","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The esophagus is classified as a type of anatomy. One classification path describes it as a tube connecting the pharynx to the stomach, noting that i... | |
medium_divergent_branch_02302 | FOXM1 interacts with multiple proteins. One specific interaction is characterized by the binding of the carboxy-terminal domain of the partner protein to FOXM1, where phosphorylation of two key residues in this domain by Cdk1 is essential for the interaction. Which cell type is enriched for the gene encoding this speci... | regulatory T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02302","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXM1 interacts with multiple proteins. One specific interaction is characterized by the binding of the carboxy-terminal domain of the partner protei... | |
medium_divergent_branch_02303 | SUV39H1 is involved in multiple biological processes. One such process is supported by evidence stating that in vivo, deregulated SUV39H1 or disrupted Suv39h activity modulates H3 serine 10 phosphorylation in native chromatin and induces aberrant mitotic divisions. Which biological process is a parent term (is_a) of th... | cellular component organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02303","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SUV39H1 is involved in multiple biological processes. One such process is supported by evidence stating that in vivo, deregulated SUV39H1 or disrupte... | |
medium_divergent_branch_02304 | SHANK2 interacts with multiple proteins. One specific interaction is described as being mediated by the PDZ domain of Shank and the C-terminal leucine zipper domain and the PDZ domain-binding motif at the extreme C terminus of a protein encoded by ARHGEF7. Which protein, encoded by the gene involved in this specific in... | Rho guanine nucleotide exchange factor 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02304","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SHANK2 interacts with multiple proteins. One specific interaction is described as being mediated by the PDZ domain of Shank and the C-terminal leucin... | |
medium_divergent_branch_02305 | APOB interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a co-immunoprecipitation approach we observed that newly synthesized APOB associates with CN and CR.' Which disease is causally linked to the protein referred to as CR in this context? | premature aging syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02305","source_qa_id":"medium_divergent_branch_01461","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"APOB interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a... | |
medium_divergent_branch_02306 | GLI3 interacts with multiple genes. One of these interaction partners is a substrate adaptor that binds linear motifs through its MATH (meprin and TRAF homology) domain and forms higher-order oligomers through its oligomerization domains, rendering it multivalent for its substrates. Which gene is this interaction partn... | SPOPL | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02306","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GLI3 interacts with multiple genes. One of these interaction partners is a substrate adaptor that binds linear motifs through its MATH (meprin and TR... | |
medium_divergent_branch_02307 | NFE2L2 interacts with multiple proteins. One specific interaction is characterized by the following mechanism: in response to the onset of colitis, the interacting partner (referred to as a specific E3 ubiquitin ligase in the evidence) directly binds to NRF2 and promotes its ubiquitin-proteasome degradation via increas... | E3 ubiquitin-protein ligase TRIM41 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02307","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFE2L2 interacts with multiple proteins. One specific interaction is characterized by the following mechanism: in response to the onset of colitis, t... | |
medium_divergent_branch_02308 | CDK9 is associated with multiple biological processes. One association is supported by evidence stating: 'While ectopic expression of cdk2 together with its regulatory subunits (cyclins E and A) inhibits myogenic transcription, overproduction of CDK9 and its associated cyclin (cyclin T2a) strengthens MyoD-dependent tra... | muscle cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02308","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK9 is associated with multiple biological processes. One association is supported by evidence stating: 'While ectopic expression of cdk2 together w... | |
medium_divergent_branch_02309 | CCL21 is associated with multiple biological processes. One specific association is supported by evidence stating that CCL19/CCL21-induced intracellular calcium mobilization in monocyte-derived dendritic cells (MoDCs) occurred only when PGE2 was present during maturation. Which biological process, connected to this spe... | calcium ion transmembrane import into cytosol | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02309","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCL21 is associated with multiple biological processes. One specific association is supported by evidence stating that CCL19/CCL21-induced intracellu... | |
medium_divergent_branch_02310 | BRD2 interacts with multiple genes. One of these interacting partners is described by the following evidence: 'These breaks were reliant on topoisomerase II, and BRD2 directly bound and activated topoisomerase I, a known restrainer of R-loops.' Which disease is associated with this specific interacting gene through gen... | adult medulloblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02310","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRD2 interacts with multiple genes. One of these interacting partners is described by the following evidence: 'These breaks were reliant on topoisome... | |
medium_divergent_branch_02311 | The gene EIF3H interacts with multiple partners. One specific interaction is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Identify the protein product encoded by the gene that corresponds to the partner described in this evidence. | Eukaryotic translation initiation factor 3 subunit M | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02311","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EIF3H interacts with multiple partners. One specific interaction is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactiva... | |
medium_divergent_branch_02312 | TNKS2 interacts with multiple genes. One of these interacting partners is described in structural and biochemical studies as acting as an optimal substrate decoy that potently hijacks substrate binding sites on TNKS1 to prevent AXIN1 PARylation and degradation. Which disease is associated with this specific interacting... | arteriovenous hemangioma/malformation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02312","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNKS2 interacts with multiple genes. One of these interacting partners is described in structural and biochemical studies as acting as an optimal sub... | |
medium_divergent_branch_02313 | BAZ1B is a component of the WICH complex. Evidence from a study on this complex states: 'We show here that the WICH complex (WSTF-SNF2h) interacts with several nuclear proteins as follows: a splicing factor subunit, RNA helicase II/Gualpha, Myb-binding protein 1a, CSB, the proto-oncogene Dek, and nuclear myosin 1 in a ... | Splicing factor 3B subunit 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02313","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BAZ1B is a component of the WICH complex. Evidence from a study on this complex states: 'We show here that the WICH complex (WSTF-SNF2h) interacts wi... | |
medium_divergent_branch_02315 | The biological process 'regulation of fatty acid metabolic process' is defined as any process that modulates the frequency, rate, or extent of the chemical reactions and pathways involving fatty acids. This process is a subtype of a broader biological process. Which broader biological process is 'regulation of fatty ac... | regulation of primary metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02315","source_qa_id":"medium_divergent_branch_00726","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of fatty acid metabolic process' is defined as any process tha... | |
medium_divergent_branch_02316 | The gene CHRNB2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that the de novo I312M mutation in CHRNB2 markedly increases the receptor's sensitivity to acetylcholine. Which molecular function, connected to the function supporte... | cation binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02316","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CHRNB2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence sta... | |
medium_divergent_branch_02317 | Human polyomavirus 2 upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.035 and an adjusted p-value of 8.23e-10. Which disease has a genomic-alteration link with that selected gene? | obesity disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02317","source_qa_id":"medium_divergent_branch_01619","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human polyomavirus 2 upregulates several genes. In the recorded experiment, one branch showed ... | |
medium_divergent_branch_02319 | The gene CDKN2C interacts with multiple proteins. One interaction partner is characterized by evidence stating that p18 directly interacted with this entity in response to DNA damage. Which protein is encoded by the gene corresponding to this interaction partner? | Serine/threonine-protein kinase ATR | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02319","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CDKN2C interacts with multiple proteins. One interaction partner is characterized by evidence stating that p18 directly interacted with this... | |
medium_divergent_branch_02320 | Gastric acid secretion is associated with multiple anatomical structures. One of these structures is described as an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ, and is lined, in whole or in part, by a glandular epithelium. Which anatomical structure ... | foregut | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02320","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Gastric acid secretion is associated with multiple anatomical structures. One of these structures is described as an expanded region of the vertebrat... | |
medium_divergent_branch_02321 | The gene KISS1 is associated with multiple biological processes. One association is supported by evidence stating that hypothalamic neurons producing kisspeptin and neurokinin B stimulate GnRH release. Identify the biological process that is positively regulated by the specific process linked to this evidence. | gonadotropin secretion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02321","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene KISS1 is associated with multiple biological processes. One association is supported by evidence stating that hypothalamic neurons producing... | |
medium_divergent_branch_02322 | The gene SCN3B is associated with multiple biological processes. One association is supported by evidence stating that 'All three SCN3B mutations caused a functionally reduced sodium channel current.' Which specific biological process, linked to SCN3B via an 'involved in' relationship, is the parent of the process desc... | cardiac muscle cell action potential involved in contraction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02322","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SCN3B is associated with multiple biological processes. One association is supported by evidence stating that 'All three SCN3B mutations cau... | |
medium_divergent_branch_02323 | The NBN gene interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show that NBS1 (mutated in Nijmegen breakage syndrome) binds to this protein after UV irradiation and mediates its recruitment to sites of DNA damage.' What is the full protein name encoded by the gene correspo... | E3 ubiquitin-protein ligase RAD18 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02323","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The NBN gene interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show that NBS1 (mutated in Nijmegen bre... | |
medium_divergent_branch_02324 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Human respirovirus 3 infection was found to upregulate a specific gene with a log2 fold change of approximately 1.24 and an adjusted p-value of approximately 0.049. What molecular function is enabled by this upregulated gene? | protein binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02324","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Human respirovirus 3 infection was found to upregulate a specific gene with ... | |
medium_divergent_branch_02325 | ATM interacts with multiple genes. One of these interacting partners binds to the N-terminal region of ATM, accelerates ATM activation, and hastens the formation of γH2AX. Which gene is this interacting partner? | TOP1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02325","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATM interacts with multiple genes. One of these interacting partners binds to the N-terminal region of ATM, accelerates ATM activation, and hastens t... | |
medium_divergent_branch_02327 | GABARAPL2 interacts with multiple proteins. One of these interaction partners is part of a group that employs ATG8 family-interacting motifs to bind preferentially to GABARAP proteins. Which protein is connected to GABARAPL2 through this specific interaction? | Kelch repeat and BTB domain-containing protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02327","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GABARAPL2 interacts with multiple proteins. One of these interaction partners is part of a group that employs ATG8 family-interacting motifs to bind ... | |
medium_divergent_branch_02328 | CDK1 interacts with multiple genes. One of these interacting partners is described in experimental evidence stating that the wild-type form of the protein binds to cyclin-dependent kinase 1, whereas a specific mutant variant (TV) does not. Which disease is associated with this specific interacting gene? | Meier-Gorlin syndrome 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02328","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK1 interacts with multiple genes. One of these interacting partners is described in experimental evidence stating that the wild-type form of the pr... | |
medium_divergent_branch_02329 | BCOR interacts with multiple genes. One interaction is supported by evidence stating: 'We show that BCOR coimmunoprecipitates isoforms of a gene encoding a protein with a JmjC domain that recently has been determined to have histone H3K36 demethylase activity.' Which disease is connected to this interaction partner thr... | urinary bladder carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02329","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCOR interacts with multiple genes. One interaction is supported by evidence stating: 'We show that BCOR coimmunoprecipitates isoforms of a gene enco... | |
medium_divergent_branch_02330 | Human gammaherpesvirus 4 downregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of -2.398 and an adjusted p-value of 0.04148. Which molecular function is enabled by the gene corresponding to this specific evidence? | protein binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02330","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human gammaherpesvirus 4 downregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of -2.398 and an adjus... | |
medium_divergent_branch_02332 | RPGRIP1 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating: 'We identified several alternatively spliced gene products, some with retina-restricted expression, that interact specifically with this protein in vivo and in vitro.' Which protein is encoded by the gene c... | X-linked retinitis pigmentosa GTPase regulator | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02332","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPGRIP1 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating: 'We identified several alternativel... | |
medium_divergent_branch_02333 | Gephyrin (GPHN) interacts with multiple proteins. One interaction is supported by evidence stating: 'In mammalian cells a protein kinase interacted with gephyrin, a widely expressed protein necessary for the clustering of glycine receptors at the cell membrane of neurons.' Which protein is encoded by the gene that inte... | Serine/threonine-protein kinase mTOR | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02333","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Gephyrin (GPHN) interacts with multiple proteins. One interaction is supported by evidence stating: 'In mammalian cells a protein kinase interacted w... | |
medium_divergent_branch_02334 | EIF4E interacts with multiple genes. One of these interacting partners is specifically noted to be associated with EIF4E in both cell compartments. Which gene is this interacting partner? | EIF4E2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02334","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF4E interacts with multiple genes. One of these interacting partners is specifically noted to be associated with EIF4E in both cell compartments. W... | |
medium_divergent_branch_02336 | ARFGEF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Interestingly, we have found that a specific protein interacts with BIG2 and BIG1, both of which are high molecular weight guanine-nucleotide exchange factors for ADP-ribosylation factors (ARFs) and mainly localize to the TGN.'... | c-Myc-binding protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02336","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARFGEF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Interestingly, we have found that a specific protein int... | |
medium_divergent_branch_02337 | ARL6IP5 interacts with multiple proteins. One of these interaction partners is described as localizing to the cell membrane and cytoplasm, and specifically interacting with the carboxy-terminal intracellular domain of a glutamate transporter. Which protein corresponds to this description? | Excitatory amino acid transporter 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02337","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARL6IP5 interacts with multiple proteins. One of these interaction partners is described as localizing to the cell membrane and cytoplasm, and specif... | |
medium_divergent_branch_02338 | ABCC2 (MRP2) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The phosphorylation-mimicking MRP2 mutant and a phosphorylated C-terminal MRP2 peptide showed significantly increased binding to IKEPP, a specific PDZ-domain-containing scaffolding protein, and both individual PDZ... | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02338","source_qa_id":"medium_divergent_branch_00309","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ABCC2 (MRP2) interacts with multiple proteins. One specific interaction is supported by evidence ... | |
medium_divergent_branch_02339 | DSCC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that hCTF18, hCTF8, and hDCC1 interact with each other as well as with the p38 subunit of RFC.' Which protein, connected to DSCC1 via this interaction, is encoded by the gene in question? | Replication factor C subunit 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02339","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DSCC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that hCTF18, hCTF8, and hDCC1 interact with... | |
medium_divergent_branch_02340 | MTOR is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'Using a proteomic strategy, we show that 5-HT(6) receptors physically interact with several proteins of the mammalian target of rapamycin (mTOR) pathway, including mTOR.' Based on this evidence, which gene enco... | 5-hydroxytryptamine receptor 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02340","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MTOR is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'Using a proteomic strategy, we show tha... | |
medium_divergent_branch_02341 | DNM1 interacts with multiple proteins. One interaction is supported by evidence that a specific protein and dynamin co-immunoprecipitated and colocalized intracellularly, and that overexpression of dynamin counteracted the inhibitory effect mediated by this protein on the endocytosis of Tf, LDL, CD59, and MHC-I. Which ... | Ubiquitin-associated and SH3 domain-containing protein A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02341","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNM1 interacts with multiple proteins. One interaction is supported by evidence that a specific protein and dynamin co-immunoprecipitated and colocal... | |
medium_divergent_branch_02343 | ACSL3 interacts with multiple proteins. One interaction is characterized by the following evidence: 'We show here that the C-lobe of the [protein] kinase domain is associated with long-chain acyl-CoA synthetase 3 (ACSL3) on the Golgi in a manner that is dependent on [protein] conformation but is independent of its kina... | Tyrosine-protein kinase Lyn | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02343","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACSL3 interacts with multiple proteins. One interaction is characterized by the following evidence: 'We show here that the C-lobe of the [protein] ki... | |
medium_divergent_branch_02344 | hsa-miR-590-5p regulates more than one cell type. Evidence indicates that hsa-miR-590-5p plays a role in opioid-induced immunosuppression in a specific cell type by targeting the CREB1/CREB5-NF-κB signaling pathway. Which cell type, connected to hsa-miR-590-5p via the 'regulates' relation, is the one described in this ... | promonocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02344","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-590-5p regulates more than one cell type. Evidence indicates that hsa-miR-590-5p plays a role in opioid-induced immunosuppression in a specif... | |
medium_divergent_branch_02345 | RCC1 interacts with multiple gene products. One interaction is supported by evidence describing the 1.8 A crystal structure of a complex between the interacting partner and RCC1 in the absence of nucleotide, representing an intermediate in the multistep GEF reaction. Which protein is encoded by the gene corresponding t... | GTP-binding nuclear protein Ran | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02345","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RCC1 interacts with multiple gene products. One interaction is supported by evidence describing the 1.8 A crystal structure of a complex between the ... | |
medium_divergent_branch_02346 | Skeletal muscle fiber differentiation is a subtype of two distinct biological processes. One of these processes is characterized by the following description: 'The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts... | myotube | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02346","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Skeletal muscle fiber differentiation is a subtype of two distinct biological processes. One of these processes is characterized by the following des... | |
medium_divergent_branch_02347 | The protein LYN is associated with multiple cellular components. One specific association is supported by evidence stating that LYN was definitely detected in purified nuclei via immunofluorescence and immunoblotting analyses. Which cell type is connected to this specific cellular component (the one supported by the nu... | erythroblast | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02347","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein LYN is associated with multiple cellular components. One specific association is supported by evidence stating that LYN was definitely de... | |
medium_divergent_branch_02348 | The gene EIF3J interacts with multiple partners. One specific interaction is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Identify the cellular component where the gene corresponding to this specific interaction is located. | eukaryotic translation initiation factor 3 complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02348","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EIF3J interacts with multiple partners. One specific interaction is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactiva... | |
medium_divergent_branch_02349 | HAX1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here, we demonstrated that HAX1 directly interacted with cellular Inhibitor of Apoptosis Proteins (cIAPs), ubiquitin E3 ligases which regulate the abundance of cellular proteins, via ubiquitin-dependent proteasomal degrad... | Baculoviral IAP repeat-containing protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02349","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HAX1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here, we demonstrated that HAX1 directly interacte... | |
medium_divergent_branch_02350 | PPARGC1A interacts with multiple genes. One of these interactions is supported by evidence stating that 'Recombinant PGC-1 directly interacted with both PXR and HNF-4 in vitro.' Which protein is encoded by the gene connected to PPARGC1A through this specific interaction? | Hepatocyte nuclear factor 4-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02350","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPARGC1A interacts with multiple genes. One of these interactions is supported by evidence stating that 'Recombinant PGC-1 directly interacted with b... | |
medium_divergent_branch_02351 | GPR37 is associated with multiple molecular functions. One association is supported by evidence stating: 'Electrophysiological recordings in frog oocytes and in mammalian cell lines as well as Ca(2+) mobilisation assays revealed nanomolar affinities of HA to GPR37.' Which molecular function, linked to GPR37 via an 'ena... | G protein-coupled peptide receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02351","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GPR37 is associated with multiple molecular functions. One association is supported by evidence stating: 'Electrophysiological recordings in frog ooc... | |
medium_divergent_branch_02352 | TRAF1 interacts with multiple genes. One interaction partner is characterized by evidence stating that MUL and this entity are capable of binding in vitro via their TRAF-binding domains (TDs) to all previously identified TRAF family proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, and TRAF6), whereas the TD of SPOP interac... | intellectual disability | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02352","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF1 interacts with multiple genes. One interaction partner is characterized by evidence stating that MUL and this entity are capable of binding in ... | |
medium_divergent_branch_02353 | FXR1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'In addition, the binding between FXR1 and the interaction partner was verified by RNA-immunoprecipitation and RNA pull-down assays, and FXR1-dependent mRNA degradation of the interaction partner was determined.' Which prote... | Kelch-like ECH-associated protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02353","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FXR1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'In addition, the binding between FXR1 and the intera... | |
medium_divergent_branch_02354 | Cangrelor interacts with multiple drugs. One of these interacting partners, when combined with the P2Y12 inhibitor cangrelor, was shown to additively inhibit thrombus formation under arterial shear. Which disease is this specific interacting drug indicated for? | mantle cell lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02354","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Cangrelor interacts with multiple drugs. One of these interacting partners, when combined with the P2Y12 inhibitor cangrelor, was shown to additively... | |
medium_divergent_branch_02355 | ARID2 interacts with multiple genes. One of these interacting partners has been shown to demonstrate protein-protein interaction and overlapping localization with ARID2 in cancer cell models. Which disease is associated with this specific interacting gene? | cervical cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02355","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARID2 interacts with multiple genes. One of these interacting partners has been shown to demonstrate protein-protein interaction and overlapping loca... | |
medium_divergent_branch_02356 | The gene SUGP2 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 8.68 TPM, a z-score of 1.95, and a fold enrichment of 2.58. Which cell type corresponds to this specific expression profile, and what is its immediate parent category in the cell type ... | group 1 innate lymphoid cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02356","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SUGP2 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 8.68 TPM, a z... | |
medium_divergent_branch_02357 | SRSF1 interacts with multiple proteins. One interaction is characterized by the finding that a docking motif in ASF/SF2 specifically binds to a groove in the partner protein, an interaction required for processive phosphorylation. Which protein corresponds to this partner? | SRSF protein kinase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02357","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SRSF1 interacts with multiple proteins. One interaction is characterized by the finding that a docking motif in ASF/SF2 specifically binds to a groov... | |
medium_divergent_branch_02358 | PTPN13 interacts with multiple proteins. One specific interaction was identified using the yeast two-hybrid system between the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E and a novel protein, named for its sequence similarity to the Zyxin protein family. Which protein is encoded by the gene c... | Thyroid receptor-interacting protein 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02358","source_qa_id":"medium_divergent_branch_05513","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PTPN13 interacts with multiple proteins. One specific interaction was identified using the yeast ... | |
medium_divergent_branch_02359 | BCL6 interacts with multiple genes. One of these interaction partners is an orphan F-box protein that forms part of a SKP1–CUL1–F-box protein (SCF) ubiquitin ligase complex, which targets BCL6 for ubiquitylation and proteasomal degradation. Which disease is associated with this specific interaction partner through geno... | chronic otitis media | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02359","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL6 interacts with multiple genes. One of these interaction partners is an orphan F-box protein that forms part of a SKP1–CUL1–F-box protein (SCF) u... | |
medium_divergent_branch_02360 | The gene CRYAA is known to interact with multiple partner genes. One specific interaction is supported by evidence stating: 'The results showed that the motifs III and IV of betaA3-crystallin were interactive with alphaA-crystallin, and motifs II and III of betaA3-crystallin primarily interacted with alphaB-crystallin.... | cataract 10 multiple types | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02360","source_qa_id":"medium_divergent_branch_03174","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene CRYAA is known to interact with multiple partner genes. One specific interaction is supp... | |
medium_divergent_branch_02361 | PRDX4 interacts with multiple genes. One interaction is supported by evidence stating: 'We identified peroxiredoxin-4 (Prx-4) as a protein interacting with the beta isoform of the thromboxane A(2) receptor (TPbeta) by yeast two-hybrid analysis.' Which disease is therapeutically linked to the gene identified in this spe... | kidney failure | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02361","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRDX4 interacts with multiple genes. One interaction is supported by evidence stating: 'We identified peroxiredoxin-4 (Prx-4) as a protein interactin... | |
medium_divergent_branch_02362 | VPS16 interacts with multiple proteins. One specific interaction is characterized by evidence stating: 'We show that HOPS subunit Vps16 recruits [the interacting partner] to the human HOPS complex and that residues 642-736 are necessary and sufficient for this interaction, and we present the crystal structure of [the i... | mucopolysaccharidosis-plus syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02362","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VPS16 interacts with multiple proteins. One specific interaction is characterized by evidence stating: 'We show that HOPS subunit Vps16 recruits [the... | |
medium_divergent_branch_02363 | GORASP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we find that TMP21, p24a, and gp25L, members of the p24 cargo receptor family, are present in complexes with GRASP55 and GRASP65 in vivo.' Which protein, connected to GORASP1 via this specific evidence, is encoded by the g... | Transmembrane emp24 domain-containing protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02363","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GORASP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we find that TMP21, p24a, and gp25L, members of the... | |
medium_divergent_branch_02364 | DDX6 interacts with multiple proteins. One interaction is supported by evidence stating: 'We also determined the crystal structure of LSM14 bound to the C-terminal RecA-like domain of DDX6.' Which protein, encoded by the gene interacting with DDX6 in this specific context, is the subject of this structural determinatio... | Protein LSM14 homolog A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02364","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDX6 interacts with multiple proteins. One interaction is supported by evidence stating: 'We also determined the crystal structure of LSM14 bound to ... | |
medium_divergent_branch_02365 | The gene NECTIN2 (PVRL2) interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that the scaffold molecule PICK-1, involved in the clustering of junctional receptors in synaptic junctions, interacts directly with Nectins in a PSD-95/Dlg/ZO-1 domain-dependent manner and is lo... | PRKCA-binding protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02365","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NECTIN2 (PVRL2) interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that the scaffold molecu... | |
medium_divergent_branch_02366 | TRIM59 interacts with multiple proteins. One specific interaction is characterized by the following mechanism: EGFR signaling leads to the upregulation of the interacting partner through SOX9 and enhances the interaction between this partner and its nuclear form, which prevents the partner's dephosphorylation by the nu... | Signal transducer and activator of transcription 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02366","source_qa_id":"medium_divergent_branch_02776","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"TRIM59 interacts with multiple proteins. One specific interaction is characterized by the followi... | |
medium_divergent_branch_02367 | BRAT1 is associated with multiple biological processes. One association is supported by evidence stating: 'By taking advantage of BRAT1 knockdown cancer cell lines, we found that loss of BRAT1 expression significantly decreases cell proliferation and tumorigenecity both in vitro and in vivo.' Which cell type is a parti... | double-positive blast | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02367","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRAT1 is associated with multiple biological processes. One association is supported by evidence stating: 'By taking advantage of BRAT1 knockdown can... | |
medium_divergent_branch_02368 | HDAC10 interacts with multiple proteins. One of these interaction partners is reported to associate with HDAC2 and a silencing mediator for retinoid and thyroid hormone receptors in coimmunoprecipitation experiments. Which protein product is encoded by the gene corresponding to this specific interaction partner? | Nuclear receptor corepressor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02368","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HDAC10 interacts with multiple proteins. One of these interaction partners is reported to associate with HDAC2 and a silencing mediator for retinoid ... | |
medium_divergent_branch_02369 | HOXA9 interacts with multiple proteins. One specific interaction is characterized by the formation of heterodimeric binding complexes on a DNA target containing a TGACAG site and an AbdB-like Hox site (TTTTACGAC). Which protein, connected to HOXA9 via this specific interaction, is the subject of the 'encodes' relation ... | Homeobox protein Meis1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02369","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HOXA9 interacts with multiple proteins. One specific interaction is characterized by the formation of heterodimeric binding complexes on a DNA target... | |
medium_divergent_branch_02370 | PJA1 interacts with multiple genes. One of these interactions involves a partner that is part of the SMC5/6 complex, which is essential for chromosome maintenance and HBV restriction, facilitating the binding of this complex to viral and episomal DNAs in the cell nucleus. Which gene is connected to PJA1 through this sp... | PWWP3A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02370","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PJA1 interacts with multiple genes. One of these interactions involves a partner that is part of the SMC5/6 complex, which is essential for chromosom... | |
medium_divergent_branch_02371 | MTOR interacts with multiple proteins. One interaction is supported by evidence stating that amino acids stimulate the GTP binding of the interacting protein and its interaction with mTORC1 and Rheb in the Golgi apparatus. Which protein, encoded by the gene connected to MTOR via this specific interaction, is the subjec... | Ras-related protein Rab-1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02371","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MTOR interacts with multiple proteins. One interaction is supported by evidence stating that amino acids stimulate the GTP binding of the interacting... | |
medium_divergent_branch_02372 | HIF1A interacts with multiple proteins. One interaction involves a ubiquitin-specific protease that rescues HIF-1α from degradation independent of its catalytic activity. Which protein is encoded by the gene corresponding to this interacting partner? | Ubiquitin carboxyl-terminal hydrolase 19 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02372","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIF1A interacts with multiple proteins. One interaction involves a ubiquitin-specific protease that rescues HIF-1α from degradation independent of it... | |
medium_divergent_branch_02373 | DDX39A interacts with multiple genes. One specific interaction partner is supported by evidence stating: 'The interactions between this partner and 8 of these SG components (PABPC1, YBX1, KHSRP, SYNCRIP, DDX39, ELAV1, EIF4A1 and EIF3F) were confirmed by anti-tag immunoprecipitation.' Which disease is associated with th... | benign neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02373","source_qa_id":"medium_divergent_branch_01726","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"DDX39A interacts with multiple genes. One specific interaction partner is supported by evidence s... | |
medium_divergent_branch_02374 | PSMA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which protein, encoded by the gene connected to PSMA2 via t... | Proteasome subunit alpha type-4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02374","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In the present study, we demonstrate that the 20S proteaso... | |
medium_divergent_branch_02375 | PDCD6IP interacts with multiple genes. One of these interaction partners is characterized by the following evidence: 'While Alix associated with both ALG-2 and TSG101 in a Ca2+-dependent manner, HD-PTP interacted with ALG-2 Ca2+-dependently but with TSG101 Ca2+-independently.' Identify the cell type in which this speci... | plasmacytoid dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02375","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDCD6IP interacts with multiple genes. One of these interaction partners is characterized by the following evidence: 'While Alix associated with both... | |
medium_divergent_branch_02376 | MAP3K8 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Through proximity-dependent biotin identification (BioID), we uncovered an E3 ligase that binds and degrades TPL2 by polyubiquitination of lysines 415 and 439.' Which protein is encoded by the gene corresponding to this... | E3 ubiquitin-protein ligase TRIM4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02376","source_qa_id":"medium_divergent_branch_01188","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MAP3K8 interacts with multiple proteins. One specific interaction is supported by evidence statin... | |
medium_divergent_branch_02377 | The protein STBD1 is associated with multiple molecular functions. One specific function is supported by evidence stating that mutation of a conserved tryptophan residue (W293) abolishes the ability of STBD1 to bind to the carbohydrate amylose. Which molecular function, connected to this amylose-binding function via an... | carbohydrate binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02377","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein STBD1 is associated with multiple molecular functions. One specific function is supported by evidence stating that mutation of a conserve... | |
medium_divergent_branch_02378 | BACE2 is associated with multiple biological processes. One association is supported by evidence that BACE2 cleaves the integral membrane form of PMEL within the juxtamembrane domain, releasing the PMEL luminal domain into endosomal precursors for the formation of amyloid fibrils and downstream melanosome morphogenesis... | pigment granule organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02378","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BACE2 is associated with multiple biological processes. One association is supported by evidence that BACE2 cleaves the integral membrane form of PME... |
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