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medium_divergent_branch_02149 | mmu-miR-140-5p regulates more than one cell type. Evidence for one of these regulatory connections states: 'Finally, we have shown that miR-140 deficiency promotes accumulation of M2 macrophages in irradiated lung tissues.' Which cell type is connected to the cell type implicated by this evidence through an 'is_a' rela... | CD4-positive, alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02149","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"mmu-miR-140-5p regulates more than one cell type. Evidence for one of these regulatory connections states: 'Finally, we have shown that miR-140 defic... | |
medium_divergent_branch_02150 | Iron interacts with multiple drugs. One of these interactions is characterized by a study showing that the plasma AUC(0-∞), Cmax, and C24 of the drug were reduced by 39%, 37%, and 39%, respectively, when co-administered with calcium carbonate while fasting, and by 54%, 57%, and 56%, respectively, when co-administered w... | HIV infectious disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02150","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Iron interacts with multiple drugs. One of these interactions is characterized by a study showing that the plasma AUC(0-∞), Cmax, and C24 of the drug... | |
medium_divergent_branch_02151 | RASSF1 interacts with multiple genes. One of these interaction partners is supported by evidence stating that 'Nore' and this partner can each efficiently homodimerize and heterodimerize with each other through their nonhomologous aminoterminal segments. Which cell type is this gene enriched in? | eosinophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02151","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RASSF1 interacts with multiple genes. One of these interaction partners is supported by evidence stating that 'Nore' and this partner can each effici... | |
medium_divergent_branch_02152 | The gene TANK interacts with multiple partners via binding. One specific interaction is supported by evidence stating: 'We found TANK formed a complex with MCPIP1 (also known as ZC3H12A) and a deubiquitinase, USP10, which was essential for the USP10-dependent deubiquitination of this interaction partner and the resolut... | TNF receptor-associated factor 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02152","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TANK interacts with multiple partners via binding. One specific interaction is supported by evidence stating: 'We found TANK formed a comple... | |
medium_divergent_branch_02153 | West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.047 and an adjusted p-value of 0.0191. For which disease is that selected gene recorded as a biomarker? | lung cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02153","source_qa_id":"medium_divergent_branch_02024","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log... | |
medium_divergent_branch_02154 | APOA1 interacts with multiple genes. One of these interacting partners has been shown to bind APOA1 through its PRY/SPRY domain and promote APOA1 polyubiquitination via its RING domain. Which cellular component is this specific interacting partner located in? | nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02154","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APOA1 interacts with multiple genes. One of these interacting partners has been shown to bind APOA1 through its PRY/SPRY domain and promote APOA1 pol... | |
medium_divergent_branch_02155 | CD274 (PD-L1) interacts with multiple proteins. One of these interacting partners is a ubiquitously expressed protein that binds PD-L1 and maintains its cell surface expression. Which gene encodes this specific interacting partner? | CD40 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02155","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD274 (PD-L1) interacts with multiple proteins. One of these interacting partners is a ubiquitously expressed protein that binds PD-L1 and maintains ... | |
medium_divergent_branch_02156 | BCL11B interacts with multiple genes. One of these interaction partners is described in literature as a C(2)H(2) zinc finger protein, specifically CTIP2 (also known as COUP TF-interacting protein 2), which is highly expressed in the brain and interacts with members of the COUP-TF subfamily of orphan nuclear receptors. ... | tarsal-carpal coalition syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02156","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL11B interacts with multiple genes. One of these interaction partners is described in literature as a C(2)H(2) zinc finger protein, specifically CT... | |
medium_divergent_branch_02157 | PCGF2 interacts with multiple proteins. One interaction is supported by evidence stating: 'A reconstituted subcomplex containing only Ring1B and Mel-18 functions as an efficient ubiquitin E3 ligase.' Which disease is associated with this specific interacting partner? | lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02157","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PCGF2 interacts with multiple proteins. One interaction is supported by evidence stating: 'A reconstituted subcomplex containing only Ring1B and Mel-... | |
medium_divergent_branch_02158 | TRAIP interacts with multiple genes. One interaction involves a partner whose binding to the LRR domain of the protein encoded by the interacting gene has been confirmed in vitro. Which protein is encoded by this specific interacting gene? | Protein flightless-1 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02158","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAIP interacts with multiple genes. One interaction involves a partner whose binding to the LRR domain of the protein encoded by the interacting gen... | |
medium_divergent_branch_02159 | SPEN interacts with multiple genes. One interaction is supported by evidence stating: 'The interaction between MINT and a ubiquitin-conjugating enzyme in mammalian cells was further proved by a series of biochemical assays including the mammalian two-hybrid assay, GST pull-down assay, and co-immunoprecipitation assay.'... | infectious mononucleosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02159","source_qa_id":"medium_divergent_branch_04659","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SPEN interacts with multiple genes. One interaction is supported by evidence stating: 'The intera... | |
medium_divergent_branch_02160 | AURKA interacts with multiple proteins. One specific interaction is characterized by the following mechanism: the interacting partner binds to Aurora A, mono-ADP-ribosylates it, and inhibits its kinase activity, thereby regulating downstream signaling. Which protein corresponds to this description? | Protein mono-ADP-ribosyltransferase PARP10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02160","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AURKA interacts with multiple proteins. One specific interaction is characterized by the following mechanism: the interacting partner binds to Aurora... | |
medium_divergent_branch_02161 | The gene OLFM1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 2.18 TPM, a z-score of 2.34, and a fold enrichment of 8.69. Which cell type corresponds to this specific statistical profile? | monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02161","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene OLFM1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 2.18 TPM, a z... | |
medium_divergent_branch_02162 | The biological process 'negative regulation of extracellular matrix constituent secretion' is defined as any process that decreases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins, by a cell or a group of cells. This pro... | secretion by cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02162","source_qa_id":"medium_divergent_branch_04056","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'negative regulation of extracellular matrix constituent secretion' is def... | |
medium_divergent_branch_02163 | RNF43 interacts with multiple proteins. One specific interaction is supported by structural evidence showing the protein bound to both LGR5 and the RNF43 ectodomain, confirming their physical linkage. Which protein, encoded by the gene connected to RNF43 via this interaction, is the subject of this structural confirmat... | R-spondin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02163","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF43 interacts with multiple proteins. One specific interaction is supported by structural evidence showing the protein bound to both LGR5 and the R... | |
medium_divergent_branch_02165 | ATG3 interacts with multiple proteins. One interaction is supported by evidence stating: 'An in vitro assay showed that Gly(120) is essential for carboxyl-terminal cleavage by human Atg4B as well as for formation of the intermediates Atg7-[Protein X] (ubiquitin-activating enzyme-substrate) and Atg3-[Protein X] (ubiquit... | Microtubule-associated protein 1 light chain 3 beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02165","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATG3 interacts with multiple proteins. One interaction is supported by evidence stating: 'An in vitro assay showed that Gly(120) is essential for car... | |
medium_divergent_branch_02166 | The lacrimal drainage system is structurally linked to multiple anatomical entities. One specific connection is described as a collection of channels that connects the conjunctival sac with the target entity, encompassing the lacrimal ducts, the lacrimal sac, and the naso-lacrimal duct. Which anatomical entity is conne... | anatomical cavity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02166","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The lacrimal drainage system is structurally linked to multiple anatomical entities. One specific connection is described as a collection of channels... | |
medium_divergent_branch_02167 | HIST1H2BB interacts with multiple genes. One of these interacting partners is described as binding to and protecting histone H2B from monoubiquitination by RNF20/RNF40 at DNA break-sites. Which biological process is this specific interacting partner involved in? | endocytic recycling | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02167","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIST1H2BB interacts with multiple genes. One of these interacting partners is described as binding to and protecting histone H2B from monoubiquitinat... | |
medium_divergent_branch_02168 | IGFBP3 interacts with multiple proteins. Evidence for one of these interactions indicates that the binding was demonstrated in a cell-free biochemical assay. Which protein is encoded by the gene corresponding to this interacting partner? | Non-POU domain-containing octamer-binding protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02168","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGFBP3 interacts with multiple proteins. Evidence for one of these interactions indicates that the binding was demonstrated in a cell-free biochemica... | |
medium_divergent_branch_02169 | NFKB2 interacts with multiple proteins. One interaction is supported by evidence stating that 'Coimmunoprecipitation assays indicate that homodimers are bound to the transcriptional coactivator Bcl-3.' Which protein is connected to the gene identified by this evidence through the 'encodes' relationship? | B-cell lymphoma 3 protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02169","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFKB2 interacts with multiple proteins. One interaction is supported by evidence stating that 'Coimmunoprecipitation assays indicate that homodimers ... | |
medium_divergent_branch_02170 | Glomerular filtration is associated with multiple anatomical structures. One of these structures is described as a cup-like sac at the expanded beginning of a tubular component of a nephron that contains the glomerulus. Which anatomical structure is this, and what larger structure is it a part of? | renal corpuscle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02170","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Glomerular filtration is associated with multiple anatomical structures. One of these structures is described as a cup-like sac at the expanded begin... | |
medium_divergent_branch_02171 | MAGED1 interacts with multiple proteins. One of these interaction partners is known to co-immunoprecipitate with NRAGE, induce the phosphorylation of c-Jun N-terminal kinase (JNK), and reduce nuclear factor kappa B (NF-κB) DNA-binding activity. Which protein is encoded by the gene corresponding to this specific interac... | Tumor necrosis factor receptor superfamily member 16 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02171","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAGED1 interacts with multiple proteins. One of these interaction partners is known to co-immunoprecipitate with NRAGE, induce the phosphorylation of... | |
medium_divergent_branch_02172 | Pharyngeal arches are anatomical structures that develop as paired bulges along the lateral walls of the foregut. They receive developmental contributions from endoderm, mesoderm, and neural crest cells, and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches. Based on this description, w... | zone of organ | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02172","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Pharyngeal arches are anatomical structures that develop as paired bulges along the lateral walls of the foregut. They receive developmental contribu... | |
medium_divergent_branch_02173 | Rift Valley fever phlebovirus downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.626 and an adjusted p-value of 0.0128. Which protein does that selected gene encode? | Tumor necrosis factor receptor superfamily member 10D | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02173","source_qa_id":"medium_divergent_branch_05049","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Rift Valley fever phlebovirus downregulates several genes. In the recorded experiment, one bra... | |
medium_divergent_branch_02175 | Melanocytes are found in multiple anatomical structures. One such structure is described as the bulb region adjacent to the dermal papilla that contains rapidly proliferating matrix cells giving rise to the various cell lineages of the hair shaft and inner root sheath. Which larger anatomical structure is this specific... | bulb of hair follicle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02175","source_qa_id":"medium_divergent_branch_03412","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Melanocytes are found in multiple anatomical structures. One such structure is described as the b... | |
medium_divergent_branch_02177 | The gene IL23A is associated with multiple biological processes. One specific association is supported by evidence stating: 'Furthermore, IL-23 upregulated CD56 expression in NK-like T cells and, together with IL-18, induced proliferation of NK and NK-like T cells.' Identify the biological process that is positively re... | NK T cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02177","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IL23A is associated with multiple biological processes. One specific association is supported by evidence stating: 'Furthermore, IL-23 upreg... | |
medium_divergent_branch_02178 | JOSD2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Next, a specific isoform of pyruvate kinase is identified as a novel interaction protein of JOSD2 by mass spectrometry, co-immunoprecipitation and co-immunofluorescence in HL60 cells.' Which protein, connected to JOSD2 v... | Pyruvate kinase PKM | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02178","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JOSD2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Next, a specific isoform of pyruvate kinase is id... | |
medium_divergent_branch_02179 | GRK6 interacts with multiple gene products. One of these interaction partners is characterized by lymphoid-restricted expression, and coimmunoprecipitation studies in myeloma cells demonstrate that its expression is regulated via direct association with the heat shock protein 90 (HSP90) chaperone. Which protein is enco... | Heat shock protein HSP 90-beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02179","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GRK6 interacts with multiple gene products. One of these interaction partners is characterized by lymphoid-restricted expression, and coimmunoprecipi... | |
medium_divergent_branch_02180 | The corticospinal tract is a component of a larger anatomical structure. Evidence for this relationship describes how corticospinal fibers, originating from pyramidal cells in layer V of the precentral motor area, premotor area, and postcentral gyrus, descend through the medulla to form the lateral and anterior cortico... | axon tract | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02180","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The corticospinal tract is a component of a larger anatomical structure. Evidence for this relationship describes how corticospinal fibers, originati... | |
medium_divergent_branch_02181 | The gene ITGA5 interacts with multiple proteins. One of these interacting partners is described by the following evidence: 'We found that this protein directly binds to a conserved cytoplasmic region of integrin α-subunits and inhibits recruitment of talin and kindlin to the integrin.' Which protein is encoded by the g... | Sharpin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02181","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ITGA5 interacts with multiple proteins. One of these interacting partners is described by the following evidence: 'We found that this protei... | |
medium_divergent_branch_02182 | WNT7B is implicated in multiple biological processes. One line of evidence notes that several Wnt proteins, including Wnt7b, are expressed in differentiating lens fiber cells. Based on this context, which biological process involving WNT7B is a component of a broader developmental process? | lens fiber cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02182","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT7B is implicated in multiple biological processes. One line of evidence notes that several Wnt proteins, including Wnt7b, are expressed in differe... | |
medium_divergent_branch_02183 | The gene BNIPL interacts with multiple partners. One specific interaction is supported by evidence stating: 'The interactions were confirmed by glutathione S-transferase pull-down assay in vitro and co-immunoprecipitation assay in vivo.' Identify the protein encoded by the gene that interacts with BNIPL according to th... | FAD-linked sulfhydryl oxidase ALR | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02183","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene BNIPL interacts with multiple partners. One specific interaction is supported by evidence stating: 'The interactions were confirmed by gluta... | |
medium_divergent_branch_02184 | IL17F is associated with multiple biological processes. One association is supported by evidence stating: 'We report a novel human IL-17 homolog, IL-17F, and show that it is expressed by activated T cells, can stimulate production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can ... | interleukin-6 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02184","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL17F is associated with multiple biological processes. One association is supported by evidence stating: 'We report a novel human IL-17 homolog, IL-... | |
medium_divergent_branch_02185 | CDCA8 interacts with multiple proteins. One interaction is supported by evidence stating: 'Biochemical analyses further demonstrated that the central domain of a histone methyltransferase interacted with the C-terminus of Borealin, and the interaction is essential to maintain the stability of Borealin.' Which protein, ... | Inactive histone-lysine N-methyltransferase 2E | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02185","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDCA8 interacts with multiple proteins. One interaction is supported by evidence stating: 'Biochemical analyses further demonstrated that the central... | |
medium_divergent_branch_02186 | VPS18 interacts with multiple genes. One of these interaction partners is described as a Beclin1-binding autophagic tumour suppressor that interacts with the class C Vps complex, a key component of the endosomal fusion machinery. Which disease is associated with this specific gene? | xeroderma pigmentosum | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02186","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VPS18 interacts with multiple genes. One of these interaction partners is described as a Beclin1-binding autophagic tumour suppressor that interacts ... | |
medium_divergent_branch_02187 | ING1 interacts with multiple genes. One specific interaction is supported by evidence stating that p33ING1 and the partner protein interact physically and co-localize to heterochromatin during the late S phase. Which disease is associated with this specific interacting partner via a biomarker relationship? | prostate cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02187","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ING1 interacts with multiple genes. One specific interaction is supported by evidence stating that p33ING1 and the partner protein interact physicall... | |
medium_divergent_branch_02189 | MAPK3 interacts with multiple proteins. One interaction is supported by evidence showing that ERK1 and ERK2 were detected in RSK3 (and to a lesser extent, a related kinase) immunoprecipitates, but were absent in RSK1 immunoprecipitates. Which protein, encoded by the gene corresponding to this specific interaction partn... | Ribosomal protein S6 kinase alpha-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02189","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK3 interacts with multiple proteins. One interaction is supported by evidence showing that ERK1 and ERK2 were detected in RSK3 (and to a lesser ex... | |
medium_divergent_branch_02190 | SMARCA4 interacts with multiple proteins. One interaction partner forms a complex with Brg1 and myocardin in vivo in smooth muscle cells, and Brg1 and Brm have been shown to directly bind to the N terminus of myocardin in vitro through their ATPase domains. Which protein is this interaction partner? | Serum response factor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02190","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMARCA4 interacts with multiple proteins. One interaction partner forms a complex with Brg1 and myocardin in vivo in smooth muscle cells, and Brg1 an... | |
medium_divergent_branch_02191 | LMO2 interacts with multiple genes. One interaction is supported by evidence stating: 'Using the RBTN2 LIM domain region as bait, the retinoblastoma-binding protein 2 (RBP2) was identified as a partner for RBTN2.' Which disease is associated with the gene identified in this specific interaction via a biomarker relation... | childhood leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02191","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LMO2 interacts with multiple genes. One interaction is supported by evidence stating: 'Using the RBTN2 LIM domain region as bait, the retinoblastoma-... | |
medium_divergent_branch_02194 | HMGB1 is associated with multiple biological processes. One association is supported by evidence that silencing HMGB1 in cord blood ECFC-derived cells confirmed its role in regulating vascular function. Which biological process, connected to the process supported by this vascular evidence, is the target of a 'positivel... | vascular endothelial cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02194","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HMGB1 is associated with multiple biological processes. One association is supported by evidence that silencing HMGB1 in cord blood ECFC-derived cell... | |
medium_divergent_branch_02195 | The gene DRG1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Our data reveal that potassium strongly stimulates the GTPase activity, without changing the monomeric status of Drg1.' Which molecular function, connected to the fun... | alkali metal ion binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02195","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DRG1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stati... | |
medium_divergent_branch_02196 | ESRRG interacts with multiple proteins. One interaction is supported by evidence stating: 'Pull-down analyses demonstrated a direct interaction of the receptor with the newly identified full-length proteins.' Which protein product is encoded by the gene corresponding to this specific interacting partner? | Proline-rich nuclear receptor coactivator 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02196","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ESRRG interacts with multiple proteins. One interaction is supported by evidence stating: 'Pull-down analyses demonstrated a direct interaction of th... | |
medium_divergent_branch_02197 | FOXM1 is associated with multiple biological processes. One association is supported by evidence stating: 'We identify a negative feedback loop involving FOXM1 that regulates reactive oxygen species (ROS) in proliferating cells.' Which biological process is connected to the process implicated by this evidence through t... | reactive oxygen species metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02197","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXM1 is associated with multiple biological processes. One association is supported by evidence stating: 'We identify a negative feedback loop invol... | |
medium_divergent_branch_02198 | DOCK9 interacts with multiple proteins. One of these interaction partners is specifically noted in experimental evidence as interacting with the Cdc42 guanine nucleotide exchange factor Zizimin1, a connection validated by co-immunoprecipitation. Which protein, among those interacting with DOCK9, is the subject of this ... | SMAD family member 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02198","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DOCK9 interacts with multiple proteins. One of these interaction partners is specifically noted in experimental evidence as interacting with the Cdc4... | |
medium_divergent_branch_02199 | CXCL14 is associated with multiple biological processes. One association is supported by evidence stating: 'In this study, we report that the chemokine CXCL14 is a broad-spectrum AMP with killing activity for cutaneous gram-positive bacteria and Candida albicans as well as the gram-negative enterobacterium Escherichia ... | antimicrobial humoral response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02199","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CXCL14 is associated with multiple biological processes. One association is supported by evidence stating: 'In this study, we report that the chemoki... | |
medium_divergent_branch_02200 | USP7 interacts with multiple proteins. One interaction partner is described in evidence stating that MUL and this partner are capable of binding in vitro via their TRAF domains (TDs) to all previously identified TRAF family proteins (TRAF1, TRAF2, TRAF3, the partner, TRAF5, and TRAF6), whereas the TD of SPOP interacts ... | TNF receptor-associated factor 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02200","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP7 interacts with multiple proteins. One interaction partner is described in evidence stating that MUL and this partner are capable of binding in v... | |
medium_divergent_branch_02202 | The gene ABCD1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Both interact with peroxisomal ABC transporters (ALDP, ALDRP, PMP70) and with full-length PEX3 as shown by in vitro protein interaction studies.' Identify the disease associated with this interacting gene via a ... | Zellweger spectrum disorders | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02202","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ABCD1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Both interact with peroxisomal ABC trans... | |
medium_divergent_branch_02204 | NFKB1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'The physical association of NF-kappa B with SF-1 was shown by yeast two-hybrid protein interaction, glutathione S-transferase pull-down, and coimmunoprecipitation (ChIP) analyses.' Which disease is associated with the gene ... | atherosclerosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02204","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFKB1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'The physical association of NF-kappa B with SF-1 was... | |
medium_divergent_branch_02205 | MCM6 interacts with multiple genes. One of these interacting partners is reported to directly interact with MCM2, MCM3, itself, and MCM7 in JeKo cells. Which disease is associated with this specific interacting partner through genomic alterations? | Seckel syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02205","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCM6 interacts with multiple genes. One of these interacting partners is reported to directly interact with MCM2, MCM3, itself, and MCM7 in JeKo cell... | |
medium_divergent_branch_02206 | The gene ID2 interacts with multiple partners. One specific interaction is supported by evidence stating: 'All three Ids bound with high affinity to E proteins, but a much broader range of interactions was observed between Ids and the class B factors.' Identify the gene that is connected to this specific interaction pa... | TLE1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02206","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ID2 interacts with multiple partners. One specific interaction is supported by evidence stating: 'All three Ids bound with high affinity to ... | |
medium_divergent_branch_02207 | NKX3-1 is associated with multiple biological processes. One specific association is supported by evidence that NKX3.1 is necessary for T-ALL proliferation, can partially restore proliferation in TAL1 knockdown cells, and directly regulates miR-17-92. Which biological process is positively regulated by the process link... | cell division | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02207","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NKX3-1 is associated with multiple biological processes. One specific association is supported by evidence that NKX3.1 is necessary for T-ALL prolife... | |
medium_divergent_branch_02208 | STX2 interacts with multiple proteins. One interaction partner is distinguished by evidence stating that Munc18a binds to syntaxin 2 alone and does not associate with other members of the core SNARE complex. Which protein is encoded by the gene corresponding to this specific interaction partner? | Syntaxin-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02208","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STX2 interacts with multiple proteins. One interaction partner is distinguished by evidence stating that Munc18a binds to syntaxin 2 alone and does n... | |
medium_divergent_branch_02209 | The tibia is defined as the major preaxial endochondral bone in the posterior zeugopod. Based on this definition, which anatomical structure is the tibia a part of? | hindlimb zeugopod | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02209","source_qa_id":"medium_divergent_branch_01159","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The tibia is defined as the major preaxial endochondral bone in the posterior zeugopod. Based on ... | |
medium_divergent_branch_02210 | IGFALS interacts with multiple proteins. One of these interaction partners is distinguished by its unique ability, among the six well-characterized IGFBPs, to form a complex with the acid-labile subunit. Which protein product is encoded by the gene corresponding to this specific interaction partner? | Insulin-like growth factor-binding protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02210","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGFALS interacts with multiple proteins. One of these interaction partners is distinguished by its unique ability, among the six well-characterized I... | |
medium_divergent_branch_02211 | USP19 interacts with multiple proteins. One of these interaction partners is characterized by the following mechanism: in response to hypoxia, it binds to USP19 and is deubiquitinated at ER-mitochondria contact sites, a process that facilitates Drp1 oligomerization and GTP-binding/hydrolysis activities, thereby promoti... | FUN14 domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02211","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP19 interacts with multiple proteins. One of these interaction partners is characterized by the following mechanism: in response to hypoxia, it bin... | |
medium_divergent_branch_02212 | PDPK1 interacts with multiple genes. One interaction is supported by evidence identifying PKC-zeta, PKC-delta, and a third protein kinase as interactors of PDK1. Which disease is associated with the gene identified in this specific evidence? | carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02212","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDPK1 interacts with multiple genes. One interaction is supported by evidence identifying PKC-zeta, PKC-delta, and a third protein kinase as interact... | |
medium_divergent_branch_02213 | The gene CDC16 interacts with multiple partners via protein-protein binding. One specific interaction is supported by evidence stating: 'In extracts prepared from M phase, but not from interphase HeLa cells, a protein encoded by the gene CDC20 coimmunoprecipitates with three important elements of the M phase checkpoint... | Cell division cycle protein 20 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02213","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CDC16 interacts with multiple partners via protein-protein binding. One specific interaction is supported by evidence stating: 'In extracts ... | |
medium_divergent_branch_02214 | GTF2I interacts with multiple genes. One interaction is supported by evidence stating: 'We found that G-kinase I beta interacted specifically with TFII-I, an unusual transcriptional regulator that associates with multiple proteins to modulate both basal and signal-induced transcription.' Which cell type is the gene ide... | basophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02214","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GTF2I interacts with multiple genes. One interaction is supported by evidence stating: 'We found that G-kinase I beta interacted specifically with TF... | |
medium_divergent_branch_02215 | IGFBP3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Multiple methodologies showed that IGFBP-3 and a nuclear receptor bind each other within the nucleus.' Which protein is encoded by the gene corresponding to the interacting partner described in this specific evidence? | Retinoic acid receptor RXR-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02215","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGFBP3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Multiple methodologies showed that IGFBP-3 and a nuclear ... | |
medium_divergent_branch_02216 | GZMB interacts with multiple proteins. One interaction is supported by evidence stating: 'The serine protease granzyme B was uncovered as the 32-kDa Hsp70-interacting protein using matrix-assisted laser desorption ionization time-of-flight mass peptide fingerprinting.' Which protein, encoded by the gene connected to GZ... | Heat shock 70 kDa protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02216","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GZMB interacts with multiple proteins. One interaction is supported by evidence stating: 'The serine protease granzyme B was uncovered as the 32-kDa ... | |
medium_divergent_branch_02217 | ATXN1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Using the yeast two-hybrid system and co-immunoprecipitation experiments, we have found that a coiled body-specific protein binds to ataxin-1.' Which disease is associated with this interacting gene via a biomarker relation... | adult lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02217","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATXN1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Using the yeast two-hybrid system and co-immunopreci... | |
medium_divergent_branch_02218 | MSL1 interacts with multiple proteins. One interaction is characterized by an extended chain forming an extensive hydrophobic interface, whereas the interaction with MOF involves electrostatic interactions between the HAT domain and a long helix of MSL1. Which protein, connected to MSL1 via a binding interaction, match... | MSL complex subunit 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02218","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MSL1 interacts with multiple proteins. One interaction is characterized by an extended chain forming an extensive hydrophobic interface, whereas the ... | |
medium_divergent_branch_02219 | NELL1 is associated with multiple biological processes. One association is supported by evidence that NELL-1 significantly inhibited the proliferation of osteoblasts co-transfected with APR3 through the further down-regulation of Cyclin D1. Which biological process is negatively regulated by the process linked to this ... | osteoblast proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02219","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NELL1 is associated with multiple biological processes. One association is supported by evidence that NELL-1 significantly inhibited the proliferatio... | |
medium_divergent_branch_02220 | NAT10 interacts with multiple genes. One of these interaction partners is an E3 ubiquitin ligase containing a zinc finger SWIM domain. Evidence indicates that RNPS1 inhibits the ubiquitination-mediated degradation of NAT10 by this ligase through direct protein interaction. Which disease is associated with this specific... | neurodevelopmental disorder with movement abnormalities, abnormal gait, and autistic features | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02220","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NAT10 interacts with multiple genes. One of these interaction partners is an E3 ubiquitin ligase containing a zinc finger SWIM domain. Evidence indic... | |
medium_divergent_branch_02221 | The gene GRM3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Follow-up co-immunoprecipitation studies demonstrated that both mGluR2 and mGluR3 can associate with a specific regulatory cofactor and another related protein in a cellular context.' Which protein, encoded by the gene co... | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02221","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene GRM3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Follow-up co-immunoprecipitation studies demonstra... | |
medium_divergent_branch_02222 | The kainate selective glutamate receptor complex is a type of cellular component. Evidence indicates that this complex is an assembly of four or five subunits forming a structure with an extracellular N-terminus and a large loop that together constitute the ligand binding domain, while the C-terminus is intracellular. ... | sodium channel activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02222","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The kainate selective glutamate receptor complex is a type of cellular component. Evidence indicates that this complex is an assembly of four or five... | |
medium_divergent_branch_02223 | HUS1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we show that each subunit of the human 9-1-1 complex physically interacts with hMSH2, hMSH3, and hMSH6.' Which protein, connected to HUS1 via an interaction, is the subject of this specific evidence? Identify the pr... | DNA mismatch repair protein Msh2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02223","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HUS1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we show that each subunit of the human 9-1-1... | |
medium_divergent_branch_02225 | PALLD interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here, we show by in vivo and in vitro methods that palladin's amino-terminal poly-proline sequences directly interact with the first carboxy-terminal SH3 domain of the protein encoded by SORBS2.' Which protein, encoded b... | Sorbin and SH3 domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02225","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PALLD interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here, we show by in vivo and in vitro methods tha... | |
medium_divergent_branch_02226 | LRP6 interacts with multiple proteins. One of these interactions was identified using IP-MS to screen for proteins interacting with LRP6. Which protein, connected to LRP6 via this interaction, is encoded by the gene in question? | Peroxiredoxin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02226","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRP6 interacts with multiple proteins. One of these interactions was identified using IP-MS to screen for proteins interacting with LRP6. Which prote... | |
medium_divergent_branch_02228 | TSPAN18 is associated with multiple biological processes. One association is supported by evidence stating: 'These findings identify TSPAN18 as a novel regulator of endothelial cell Orai1/Ca2+ signaling and von Willebrand factor release in response to inflammatory stimuli.' Which biological process, connected to TSPAN1... | intracellular signaling cassette | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02228","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TSPAN18 is associated with multiple biological processes. One association is supported by evidence stating: 'These findings identify TSPAN18 as a nov... | |
medium_divergent_branch_02229 | GABARAP interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Quantitative yeast two-hybrid assays were used to identify the interaction domain in the gamma2 subunit for GABARAP binding, and to identify the interaction domain in GABARAP for GABA(A) receptor binding.' Which protei... | Gamma-aminobutyric acid receptor subunit gamma-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02229","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GABARAP interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Quantitative yeast two-hybrid assays were used ... | |
medium_divergent_branch_02230 | NUP62 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We demonstrated physical interaction between this protein and p62 both by a glutathione S-transferase (GST) pull-down assay in vitro and by a two-hybrid assay in K562 cells.' Which protein corresponds to the gene linked ... | Heat shock factor protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02230","source_qa_id":"medium_divergent_branch_04400","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"NUP62 interacts with multiple proteins. One specific interaction is supported by evidence stating... | |
medium_divergent_branch_02231 | ZUFSP interacts with multiple components of the replication protein A (RPA) complex. Evidence indicates that ZUFSP interacts with and modulates the ubiquitination of this complex. Which protein, encoded by one of the genes interacting with ZUFSP, is the 70 kDa DNA-binding subunit of the RPA complex? | Replication protein A 70 kDa DNA-binding subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02231","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZUFSP interacts with multiple components of the replication protein A (RPA) complex. Evidence indicates that ZUFSP interacts with and modulates the u... | |
medium_divergent_branch_02232 | RAD51 interacts with multiple proteins. One interaction is supported by evidence stating: 'In several cell lines, a specific protein appeared in the immunoprecipitates of RAD51, whereas LC3, Ulk1 and this same protein interacted with PARP-1, another protein involved in DNA repair and genomic stability.' Which protein i... | Sequestosome-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02232","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD51 interacts with multiple proteins. One interaction is supported by evidence stating: 'In several cell lines, a specific protein appeared in the ... | |
medium_divergent_branch_02233 | Paxillin (PXN) interacts with multiple proteins. One of these interaction partners is described in the following evidence: 'Here, we identify this protein, a member of the tripartite motif protein family, as a paxillin-interacting factor and a component of focal adhesions.' Which protein is encoded by the gene correspo... | E3 ubiquitin-protein ligase TRIM15 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02233","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Paxillin (PXN) interacts with multiple proteins. One of these interaction partners is described in the following evidence: 'Here, we identify this pr... | |
medium_divergent_branch_02234 | FZR1 interacts with multiple proteins. One of these interaction partners contains a KEN box sequence in its C-terminal region, which is required for its mitotic degradation and its interaction with Cdh1. Which protein is encoded by the gene corresponding to this interaction partner? | Thymidine kinase, cytosolic | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02234","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FZR1 interacts with multiple proteins. One of these interaction partners contains a KEN box sequence in its C-terminal region, which is required for ... | |
medium_divergent_branch_02235 | SIMC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We isolated SIMC1 from the proteomic environment of SMC5/6 within polyomavirus large T antigen (LT)-induced subnuclear compartments.' Which protein, connected to SIMC1 via an interaction, is described by this evidence? Provide th... | Structural maintenance of chromosomes protein 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02235","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIMC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We isolated SIMC1 from the proteomic environment of SMC5/6... | |
medium_divergent_branch_02236 | CLK2 interacts with multiple proteins. One of these interaction partners is known to directly bind to and phosphorylate CLK2 on serine 34 and threonine 127, both in vitro and in vivo. Which protein corresponds to this specific interaction partner? | RAC-alpha serine/threonine-protein kinase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02236","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLK2 interacts with multiple proteins. One of these interaction partners is known to directly bind to and phosphorylate CLK2 on serine 34 and threoni... | |
medium_divergent_branch_02237 | BIRC2 interacts with multiple genes. One of these interaction partners is described in the context as being localized on midbody microtubules at telophase and interacting with cIAP1 during mitosis. Which disease is connected to this specific interaction partner through genomic alterations? | asthma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02237","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BIRC2 interacts with multiple genes. One of these interaction partners is described in the context as being localized on midbody microtubules at telo... | |
medium_divergent_branch_02238 | CASP6 is associated with multiple biological processes. One association is supported by evidence stating that Caspase-6 plays an important role in axonal degeneration during neuronal apoptosis. Which biological process, connected to the process supported by this evidence via an 'is a' relationship, represents the broad... | regulation of cellular process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02238","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CASP6 is associated with multiple biological processes. One association is supported by evidence stating that Caspase-6 plays an important role in ax... | |
medium_divergent_branch_02239 | RMI1 is known to interact with multiple proteins. One specific interaction is described by the evidence: 'MM2 interacts with RM1 and topoisomerase IIIalpha, components of the BS complex.' Identify the disease associated with the gene mentioned in this specific evidence statement through genomic alterations. | microcephaly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02239","source_qa_id":"medium_divergent_branch_01338","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"RMI1 is known to interact with multiple proteins. One specific interaction is described by the ev... | |
medium_divergent_branch_02240 | MIR34A is associated with multiple biological processes. One association is supported by evidence stating: 'Mechanistically, we identified PNUTS (also known as PPP1R10) as a novel direct miR-34a target, which reduces telomere shortening, DNA damage responses and cardiomyocyte apoptosis, and improves functional recovery... | cardiac muscle cell apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02240","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR34A is associated with multiple biological processes. One association is supported by evidence stating: 'Mechanistically, we identified PNUTS (als... | |
medium_divergent_branch_02241 | Cytochrome c (CYCS) interacts with multiple proteins. One specific interaction partner was identified as an interacting partner of cytochrome c through Co-immunoprecipitation (CO-IP) assays combined with mass spectrometry (MS) and gene set enrichment analysis (GSEA). Which disease is associated with this specific inter... | cholestasis, progressive familial intrahepatic, 7, with or without hearing loss | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02241","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Cytochrome c (CYCS) interacts with multiple proteins. One specific interaction partner was identified as an interacting partner of cytochrome c throu... | |
medium_divergent_branch_02242 | ERCC8 interacts with multiple proteins. One interaction is supported by evidence stating: 'After cell irradiation with UV light, CSA triggers the dissociation of the CSA-[protein]-CSB-RNAP1-RPs complex from the chromatin while it stabilizes its binding to [protein].' Which protein, connected to ERCC8 via an interaction... | Ferrochelatase, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02242","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERCC8 interacts with multiple proteins. One interaction is supported by evidence stating: 'After cell irradiation with UV light, CSA triggers the dis... | |
medium_divergent_branch_02243 | DNM1 interacts with multiple genes. One interaction is supported by evidence stating: 'For example, SH3 domains from c-Src, Grb2, and intersectin bound only to the C-terminal half of dynamin-2 PRD but to both the N- and C-terminal portions of dynamin-1 PRD.' Which disease is causally linked to the gene involved in this... | malignant glioma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02243","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNM1 interacts with multiple genes. One interaction is supported by evidence stating: 'For example, SH3 domains from c-Src, Grb2, and intersectin bou... | |
medium_divergent_branch_02245 | PLCB2 interacts with multiple proteins. One specific interaction was identified using the yeast two-hybrid technique to screen a leukocyte library, which revealed a specific mitogen-activated protein kinase kinase as a partner of PLC-beta 2. Which protein is encoded by the gene corresponding to this identified partner? | Dual specificity mitogen-activated protein kinase kinase 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02245","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLCB2 interacts with multiple proteins. One specific interaction was identified using the yeast two-hybrid technique to screen a leukocyte library, w... | |
medium_divergent_branch_02246 | FHL1 is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'A physical and direct interaction of both proteins was observed in vitro.' Which protein product is encoded by the gene corresponding to this specific interacting partner? | Potassium voltage-gated channel subfamily A member 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02246","source_qa_id":"medium_divergent_branch_00062","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FHL1 is known to interact with multiple proteins. One specific interaction is supported by eviden... | |
medium_divergent_branch_02248 | RNF4 interacts with multiple genes. One specific interaction is supported by structural evidence reporting the RING-domain dimer of rat RNF4 in complex with a human partner protein, a Ub conjugate, and Ube2V2. Which disease is associated with this specific interacting partner? | fetal alcohol syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02248","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF4 interacts with multiple genes. One specific interaction is supported by structural evidence reporting the RING-domain dimer of rat RNF4 in compl... | |
medium_divergent_branch_02249 | PRAME interacts with multiple genes. One interaction is supported by evidence stating: 'We applied protein-complex purification strategies and identified PRAME as a substrate recognition subunit of a Cullin2-based E3 ubiquitin ligase.' Which disease is associated with the gene identified in this specific context? | ulcerative colitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02249","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRAME interacts with multiple genes. One interaction is supported by evidence stating: 'We applied protein-complex purification strategies and identi... | |
medium_divergent_branch_02250 | The protein NUMA1 is associated with multiple molecular functions via the 'enables' relationship. One specific function is supported by evidence stating: 'We show here that NuMA can bind to microtubules independently of dynein/dynactin.' Identify the cellular component that serves as the primary input for this specific... | microtubule | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02250","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein NUMA1 is associated with multiple molecular functions via the 'enables' relationship. One specific function is supported by evidence stat... | |
medium_divergent_branch_02251 | DISC1 interacts with multiple genes. One of these interaction partners is characterized by experimental evidence (yeast two-hybrid, mammalian two-hybrid, and co-immunoprecipitation) showing it interacts with proteins of the centrosome and cytoskeletal system (including MIPT3, MAP1A, and NUDEL), proteins that localize r... | neurodevelopmental disorder with hypotonia, neuropathy, and deafness | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02251","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DISC1 interacts with multiple genes. One of these interaction partners is characterized by experimental evidence (yeast two-hybrid, mammalian two-hyb... | |
medium_divergent_branch_02252 | NDC80 interacts with multiple proteins. One of these interaction partners is described in the following context: 'Here, we show that Cdk1 phosphorylates this protein to promote its direct binding to the Ndc80 complex (Ndc80C), a core outer kinetochore component.' Which protein, encoded by the gene corresponding to this... | Spindle and kinetochore-associated protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02252","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NDC80 interacts with multiple proteins. One of these interaction partners is described in the following context: 'Here, we show that Cdk1 phosphoryla... | |
medium_divergent_branch_02253 | SIAH1 interacts with multiple proteins. One of these interaction partners is described in experimental evidence where SHP binds to it and disrupts its interaction with the E3 ubiquitin ligase SIAH1. Which protein corresponds to this interaction partner? | E3 SUMO-protein ligase PIAS1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02253","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIAH1 interacts with multiple proteins. One of these interaction partners is described in experimental evidence where SHP binds to it and disrupts it... | |
medium_divergent_branch_02254 | The gene CDH23 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 27.13 TPM, a z-score of 1.96, and a fold enrichment of 6.22. Identify the cell type that corresponds to this statistical profile, and then determine which cell type it develops from. | classical monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02254","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CDH23 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 27.13 TPM, a z-score of ... | |
medium_divergent_branch_02255 | CEP55 interacts with multiple proteins. One specific interaction partner is characterized by evidence stating that it and ALIX concentrate at centrosomes and are recruited to the midbodies of dividing cells through direct interactions between the central CEP55 'hinge' region and GPP-based motifs within the partner prot... | Tumor susceptibility gene 101 protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02255","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CEP55 interacts with multiple proteins. One specific interaction partner is characterized by evidence stating that it and ALIX concentrate at centros... | |
medium_divergent_branch_02256 | Positive T cell selection involves multiple cell types. One participant is described as a double-positive thymocyte undergoing positive selection, characterized by high expression of the alpha-beta T cell receptor, CD69 positivity, and the active downregulation of the CD4 co-receptor. Which cell type does this specific... | CD69-positive double-positive thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02256","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Positive T cell selection involves multiple cell types. One participant is described as a double-positive thymocyte undergoing positive selection, ch... | |
medium_divergent_branch_02257 | The gene ADRA1B is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence showing that MURC/Cavin-4 binds to α1A- and α1B-adrenergic receptors (ARs) as well as ERK1/2 within caveolae. Given this context, which cellular component is connected to ... | cell periphery | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02257","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ADRA1B is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence ... | |
medium_divergent_branch_02258 | WWTR1 interacts with multiple genes. One of these interaction partners is described as a PDZ domain-containing protein that uses a specific motif to bind TAZ and functions to tether plasma membrane ion channels and receptors to cytoskeletal actin. Which disease is associated with this specific interaction partner? | colitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02258","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WWTR1 interacts with multiple genes. One of these interaction partners is described as a PDZ domain-containing protein that uses a specific motif to ... | |
medium_divergent_branch_02259 | The growth hormone secretagogue receptor (GHSR) is associated with multiple biological processes. One association is supported by evidence stating: 'Although pharmacological studies have demonstrated that its endogenous ligand--ghrelin--stimulates, through the GHSR, GH secretion and appetite...' Identify the biological... | peptide hormone secretion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02259","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The growth hormone secretagogue receptor (GHSR) is associated with multiple biological processes. One association is supported by evidence stating: '... | |
medium_divergent_branch_02260 | The gene HTT interacts with multiple proteins. One interaction is supported by evidence stating: 'Consistent with its role as an E3 for httN, we demonstrate that the protein encoded by the gene associated with this specific evidence interacts with and ubiquitinates httN.' Which protein, connected to HTT via an interact... | E3 ubiquitin-protein ligase synoviolin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02260","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HTT interacts with multiple proteins. One interaction is supported by evidence stating: 'Consistent with its role as an E3 for httN, we demo... |
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