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medium_divergent_branch_02495 | TRIM32 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Mechanistically, we discovered that TRIM32 directly bound to the protein encoded by this gene via mass spectrometry and co-immunoprecipitation.' What is the name of the protein encoded by the gene that interacts with TR... | Fructose-1,6-bisphosphatase isozyme 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02495","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM32 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Mechanistically, we discovered that TRIM32 direc... | |
medium_divergent_branch_02497 | MAP3K5 (ASK1) interacts with multiple genes. One interaction partner is described as a MAPKKK that serves as a signaling intermediate in the IL-1-induced NF-kappaB pathway and the TGF-beta superfamily-induced JNK/p38 pathway, and is known to directly interact with ASK1. Which disease is associated with this specific in... | cardiospondylocarpofacial syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02497","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K5 (ASK1) interacts with multiple genes. One interaction partner is described as a MAPKKK that serves as a signaling intermediate in the IL-1-ind... | |
medium_divergent_branch_02498 | The gene IER3 (also known as IEX-1) interacts with multiple partners. One specific interaction involves IEX-1 binding to B56 subunits and pERK independently, enhancing B56 phosphorylation by ERK at a conserved Ser/Pro site within this complex, and triggering dissociation from the catalytic subunit. Which protein is enc... | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02498","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IER3 (also known as IEX-1) interacts with multiple partners. One specific interaction involves IEX-1 binding to B56 subunits and pERK indepe... | |
medium_divergent_branch_02500 | TREM2 is associated with multiple biological processes. One of these processes is characterized by evidence that TREM2 signals through PLCγ2 to mediate cell survival, phagocytosis, processing of neuronal debris, and lipid metabolism. Which biological process is positively regulated by this specific TREM2-associated pro... | intracellular signal transduction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02500","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TREM2 is associated with multiple biological processes. One of these processes is characterized by evidence that TREM2 signals through PLCγ2 to media... | |
medium_divergent_branch_02501 | The gene ECD interacts with multiple partners. One specific interaction involves a protein that competitively binds to hnRNP F via its N-terminal STG1 domain (residues 13-383), thereby blocking the interaction between hnRNP F and ZFP91 and preventing the subsequent ubiquitination and proteasomal degradation of hnRNP F.... | Heterogeneous nuclear ribonucleoprotein F | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02501","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ECD interacts with multiple partners. One specific interaction involves a protein that competitively binds to hnRNP F via its N-terminal STG... | |
medium_divergent_branch_02502 | DAG1 interacts with multiple genes. One interaction is supported by evidence stating: 'The C-terminal region of the protein encoded by the interacting gene binds the cytoplasmic tail of beta-dystroglycan, in part through the interaction of its WW domain with a proline-rich motif in the tail of beta-dystroglycan.' Which... | neuromuscular disease caused by qualitative or quantitative defects of dystrophin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02502","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DAG1 interacts with multiple genes. One interaction is supported by evidence stating: 'The C-terminal region of the protein encoded by the interactin... | |
medium_divergent_branch_02503 | The transcription factor PROX1 is involved in multiple biological processes. One specific process is supported by evidence stating that in the endoderm, PROX1 serves as a marker for hepatocytes, bile ducts, and pancreatic epithelium. Which anatomical structure is the result of the development driven by this specific bi... | liver | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02503","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The transcription factor PROX1 is involved in multiple biological processes. One specific process is supported by evidence stating that in the endode... | |
medium_divergent_branch_02504 | The gene BACE2 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 48.51 TPM, a z-score of 2.14, and a fold enrichment of 9.44. Which cell type corresponds to this specific expression profile, and what is its immediate parent category in the cell type hierarchy ... | mature B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02504","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene BACE2 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 48.51 TPM, a z-score of ... | |
medium_divergent_branch_02505 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.186 and an adjusted p-value of 0.0459. Which protein does that selected gene encode? | Thymocyte nuclear protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02505","source_qa_id":"medium_divergent_branch_01939","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_02506 | BIN1 is associated with multiple biological processes. One association is supported by evidence that BIN1 overexpression in undifferentiated neuroblastoma and astrocytoma cells leads to a significant reduction in cell growth, an increase in the G(0)/G(1) cell population, and the induction of apoptosis. Which biological... | apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02506","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BIN1 is associated with multiple biological processes. One association is supported by evidence that BIN1 overexpression in undifferentiated neurobla... | |
medium_divergent_branch_02507 | SSBP2 interacts with multiple genes. Evidence for one of these interactions notes that hSSB1 and hSSB2 form separate complexes with two identical proteins, the shared interaction partner and hSSBIP1 (C9ORF80). Which gene is connected to SSBP2 through an interaction with this shared partner? | SSBP1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02507","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SSBP2 interacts with multiple genes. Evidence for one of these interactions notes that hSSB1 and hSSB2 form separate complexes with two identical pro... | |
medium_divergent_branch_02508 | KCNE1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that KCNE1 encodes beta-subunits (hminK) which co-assemble with KvLQT1 alpha-subunits to form the slowly activating delayed rectifier K+ (IKs) channel. Which molecular function... | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02508","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCNE1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that ... | |
medium_divergent_branch_02509 | RAB6A is associated with multiple biological processes. One association is supported by evidence that GCC185 binds Rab6, and that mutating residues required for this binding abolishes Golgi localization. Which broader biological process is a parent of the specific process linked by this evidence? | protein localization to organelle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02509","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB6A is associated with multiple biological processes. One association is supported by evidence that GCC185 binds Rab6, and that mutating residues r... | |
medium_divergent_branch_02510 | hsa-miR-210-5p regulates more than one type of T cell. One line of evidence states: 'Here, we report that microRNA-210 (miR-210), a miR that is highly expressed in both psoriasis patients and mouse models, induces helper T (Th) 17 and Th1 cell differentiation but inhibits Th2 differentiation through repressing STAT6 an... | CD4-positive helper T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02510","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-210-5p regulates more than one type of T cell. One line of evidence states: 'Here, we report that microRNA-210 (miR-210), a miR that is highl... | |
medium_divergent_branch_02511 | FAM3C is reported to interact with multiple proteins. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation experiments established direct interaction of endogenous ILEI and this protein.' Which protein product is encoded by the gene corresponding to this interaction partner? | Ubiquitin conjugation factor E4 A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02511","source_qa_id":"medium_divergent_branch_02796","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FAM3C is reported to interact with multiple proteins. One specific interaction is supported by ev... | |
medium_divergent_branch_02513 | West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.205 and an adjusted p-value of 0.011. For which disease is that selected gene recorded as a biomarker? | intervertebral disk degenerative disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02513","source_qa_id":"medium_divergent_branch_01996","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log... | |
medium_divergent_branch_02514 | MAP1S is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that the protein 'decorates neuronal microtubules and copurifies with tubulin from brain.' Identify the molecular function linked to this specific association through the 'is_a... | cytoskeletal protein binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02514","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP1S is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that ... | |
medium_divergent_branch_02515 | PI4KB is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating that PI4KB is critical for maintaining PI4P pools in the Golgi and trans-Golgi network (TGN), although its precise targeting mechanism to these membranes remains unknown. Wh... | bounding membrane of organelle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02515","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PI4KB is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating th... | |
medium_divergent_branch_02516 | The gene CA6 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 16.11 TPM, a z-score of 3.16, and a fold enrichment of 17.64. Which cell type, identified by this specific expression profile, develops from a mature single-positive thymocyte? | mature CD8 single-positive thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02516","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CA6 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 16.11 TPM, a z-... | |
medium_divergent_branch_02518 | The protein NPC2 is associated with multiple molecular functions. One specific function is supported by evidence stating: 'Whereas NPC2 rapidly donates or accepts cholesterol from liposomes, NPC1(NTD) acts much more slowly.' Identify the parent molecular function (via an 'is_a' relationship) of the specific function de... | transporter activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02518","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein NPC2 is associated with multiple molecular functions. One specific function is supported by evidence stating: 'Whereas NPC2 rapidly donat... | |
medium_divergent_branch_02519 | SIM2 interacts with multiple proteins. One of these interaction partners is reported to bind and positively regulate the transcriptional activity of SIM1, SIM2, NPAS4, and itself, while notably not interacting with AhR, HIF1α, or ARNT. Which protein is encoded by the gene corresponding to this specific interaction part... | Melanoma-associated antigen D1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02519","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIM2 interacts with multiple proteins. One of these interaction partners is reported to bind and positively regulate the transcriptional activity of ... | |
medium_divergent_branch_02521 | UFL1 interacts with multiple genes. One of these interaction partners functions by recruiting the UFL1 ligase to the endoplasmic reticulum (ER) surface to UFMylate RPN1 and RPL26, thereby preferentially targeting ER sheets for degradation in a manner analogous to PINK1-Parkin regulation during mitophagy. Which disease ... | thrombocytopenia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02521","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UFL1 interacts with multiple genes. One of these interaction partners functions by recruiting the UFL1 ligase to the endoplasmic reticulum (ER) surfa... | |
medium_divergent_branch_02522 | The KIT gene interacts with multiple partners via binding. One specific interaction is characterized by the following evidence: 'We show that the expression of the target gene mRNA is rapidly increased in primary bone marrow-derived mast cells following exposure to Steel factor, and the target gene product inducibly bi... | Suppressor of cytokine signaling 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02522","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The KIT gene interacts with multiple partners via binding. One specific interaction is characterized by the following evidence: 'We show that the exp... | |
medium_divergent_branch_02524 | JAK1 is known to bind to multiple genes. One specific interaction is supported by evidence stating: 'In the process we found that the JH2 domain of JAK1, JAK2 or JAK3 could specifically associate with the carboxy-terminal portion of STAT5, but not with STAT3 or STAT1.' Based on this evidence, which gene connected to JA... | SOCS2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02524","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JAK1 is known to bind to multiple genes. One specific interaction is supported by evidence stating: 'In the process we found that the JH2 domain of J... | |
medium_divergent_branch_02527 | RNF43 interacts with multiple genes. One of these interactions is characterized by the requirement that suppression of Wnt/β-catenin signaling depends on the interaction between the extracellular protease-associated (PA) domain and the cysteine-rich domain (CRD) of frizzled receptors and the intracellular RING finger d... | microphthalmia/coloboma 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02527","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF43 interacts with multiple genes. One of these interactions is characterized by the requirement that suppression of Wnt/β-catenin signaling depend... | |
medium_divergent_branch_02528 | TP53BP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have used protein purification and mass spectrometry to identify the 53BP1 tumour suppressor as a novel [interacting partner]-associated protein.' Which protein product is encoded by the gene corresponding to this specific i... | Nuclear receptor coactivator 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02528","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TP53BP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have used protein purification and mass spectrometry ... | |
medium_divergent_branch_02529 | SOX5 interacts with multiple genes. One of these interaction partners was identified in a study reporting seven novel FOXP-interacting transcription factors (NR2F1, NR2F2, SATB1, SATB2, SOX5, YY1, and ZMYM2), noting that five of them have well-established roles in cortical development. Which disease is associated with ... | childhood apraxia of speech | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02529","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX5 interacts with multiple genes. One of these interaction partners was identified in a study reporting seven novel FOXP-interacting transcription ... | |
medium_divergent_branch_02530 | Human respirovirus 3 upregulates multiple genes. One such gene exhibits a log2 fold change of approximately 1.91 and an adjusted p-value of approximately 0.042 in non-small cell lung adenocarcinoma cell lines (study GSE147507). Which disease is associated with this specific gene via a biomarker relationship? | coronary artery disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02530","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human respirovirus 3 upregulates multiple genes. One such gene exhibits a log2 fold change of approximately 1.91 and an adjusted p-value of approxima... | |
medium_divergent_branch_02532 | MAVS interacts with multiple proteins. One of these interactors functions by removing K63-linked polyubiquitin chains from MAVS, thereby inhibiting viral-induced MAVS-TBK1-IRF3 activation and downstream inflammatory gene expression. Which protein corresponds to this specific mechanistic role? | Ubiquitin carboxyl-terminal hydrolase 35 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02532","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAVS interacts with multiple proteins. One of these interactors functions by removing K63-linked polyubiquitin chains from MAVS, thereby inhibiting v... | |
medium_divergent_branch_02533 | BAIAP2 interacts with multiple proteins. One of these interaction partners was identified as IRSp53 using a yeast two-hybrid screen that utilized the proline-rich region of the partner protein. Which protein, connected to BAIAP2 via an interaction, is the subject of this specific experimental evidence? | SH3 and multiple ankyrin repeat domains protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02533","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BAIAP2 interacts with multiple proteins. One of these interaction partners was identified as IRSp53 using a yeast two-hybrid screen that utilized the... | |
medium_divergent_branch_02534 | The biological process 'positive regulation of type 2 immune response' is enabled by multiple cell types. One of these cell types is described as a mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses. Which cell type is the developm... | activated CD4-positive type I NK T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02534","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The biological process 'positive regulation of type 2 immune response' is enabled by multiple cell types. One of these cell types is described as a m... | |
medium_divergent_branch_02535 | PCBP2 interacts with multiple proteins. One interaction is supported by experimental evidence stating: 'Furthermore, we selected several prey proteins from the interactome data and confirmed that a specific protein interacted with ancient ubiquitous protein 1 (AUP1), Fas-associated factor family member 2 (FAF2), tripar... | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02535","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PCBP2 interacts with multiple proteins. One interaction is supported by experimental evidence stating: 'Furthermore, we selected several prey protein... | |
medium_divergent_branch_02536 | The biological process 'negative regulation of dendritic cell cytokine production' is defined as any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production. This process is a subtype of a broader biological process. Which biological process is negatively regulated ... | cytokine production involved in immune response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02536","source_qa_id":"medium_divergent_branch_04920","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'negative regulation of dendritic cell cytokine production' is defined as ... | |
medium_divergent_branch_02537 | PRKN interacts with multiple proteins. One interaction is supported by evidence stating: 'Importantly, we further demonstrated that the recruitment of [E2 ubiquitin-conjugating enzyme] (an E2 that mediates K63-linked polyubiquitin chain formation exclusively) by Parkin is selectively enhanced under conditions of protea... | Ubiquitin-conjugating enzyme E2 N | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02537","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKN interacts with multiple proteins. One interaction is supported by evidence stating: 'Importantly, we further demonstrated that the recruitment o... | |
medium_divergent_branch_02538 | Desmoplakin (DSP) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In extracts from HaCaT cells, distinct soluble complexes containing PKP1a and desmoplakin I (DPI) have been identified by co-immunoprecipitation and sucrose density fractionation.' Which protein, encoded by t... | Plakophilin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02538","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Desmoplakin (DSP) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In extracts from HaCaT cells, distinc... | |
medium_divergent_branch_02539 | ARPC1B interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here we show that p41-Arc interacts with p21-activated kinase 1 both in vitro and in vivo.' Which disease is connected to this interaction partner through genomic alterations? | megalencephaly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02539","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARPC1B interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here we show that p41-Arc interacts with p21-activa... | |
medium_divergent_branch_02540 | The gene EIF2B2 is associated with multiple biological processes. One association is supported by evidence stating that autosomal recessive mutations in the eukaryotic initiation factor 2B (eIF2B) subunits cause white matter abnormalities and a spectrum of clinical signs known as eIF2B-related disorders. Which biologic... | system development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02540","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EIF2B2 is associated with multiple biological processes. One association is supported by evidence stating that autosomal recessive mutations... | |
medium_divergent_branch_02541 | COMMD1 interacts with multiple proteins. One specific interaction partner requires CCS-mediated copper incorporation for the interaction to occur. Which protein is this interaction partner? | Superoxide dismutase [Cu-Zn] | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02541","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COMMD1 interacts with multiple proteins. One specific interaction partner requires CCS-mediated copper incorporation for the interaction to occur. Wh... | |
medium_divergent_branch_02543 | SERTAD1 interacts with multiple proteins. One interaction partner is an E3 ubiquitin ligase that, in complex with TRIP-Br1, promotes the degradation of IGF1R via the ubiquitin-proteasome system. Which gene encodes this specific E3 ubiquitin ligase? | E3 ubiquitin-protein ligase NEDD4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02543","source_qa_id":"medium_divergent_branch_07102","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SERTAD1 interacts with multiple proteins. One interaction partner is an E3 ubiquitin ligase that,... | |
medium_divergent_branch_02544 | SPOP interacts with multiple proteins. One specific interaction involves an adaptor protein of the Cullin 3 family E3 ligase that promotes the poly-ubiquitination and subsequent degradation of its binding partner in a degron-dependent manner. Which protein, connected to SPOP through this specific interaction, is encode... | Cell division cycle protein 20 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02544","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SPOP interacts with multiple proteins. One specific interaction involves an adaptor protein of the Cullin 3 family E3 ligase that promotes the poly-u... | |
medium_divergent_branch_02545 | AZI2 interacts with multiple proteins. One of these interaction partners is described in evidence stating that SINTBAD constitutively binds TBK1 and a specific kinase, but not related kinases. Which protein is encoded by the gene corresponding to this specific interaction partner? | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02545","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AZI2 interacts with multiple proteins. One of these interaction partners is described in evidence stating that SINTBAD constitutively binds TBK1 and ... | |
medium_divergent_branch_02546 | MAGEH1 is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'Here we identify two MAGE proteins, necdin and MAGE-H1, as interactors for the intracellular domain of p75 and show that the interaction is enhanced by ligand stimulation.' Based on this evidence, which prote... | Tumor necrosis factor receptor superfamily member 16 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02546","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAGEH1 is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'Here we identify two MAGE proteins, n... | |
medium_divergent_branch_02547 | The NF2 gene interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified the cyclin B-binding protein and cell cycle regulator [protein encoded by CCNB1IP1] as a novel merlin-binding partner.' Which protein, encoded by the gene interacting with NF2 in this specific context, is the... | E3 ubiquitin-protein ligase CCNB1IP1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02547","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The NF2 gene interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified the cyclin B-binding protein and cell... | |
medium_divergent_branch_02548 | MIR26A1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'In summary, miRNA-26a promotes vascular SMC proliferation while inhibiting cellular differentiation and apoptosis, and alters TGF-β pathway signaling.' Which biological process, connected to the process... | vascular associated smooth muscle cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02548","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR26A1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'In summary, miRNA-26a promotes ... | |
medium_divergent_branch_02549 | PRKCD interacts with multiple proteins. One interaction is supported by evidence stating: 'After neutrophil activation, PKC-delta was the only PKC isotype that associated with p60TNFR within the correct time frame for receptor phosphorylation.' Which protein is encoded by the gene that interacts with PRKCD in this spec... | Tumor necrosis factor receptor superfamily member 1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02549","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKCD interacts with multiple proteins. One interaction is supported by evidence stating: 'After neutrophil activation, PKC-delta was the only PKC is... | |
medium_divergent_branch_02550 | West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.067 and an adjusted p-value of 0.0472. In which cellular component is that selected gene located? | cytoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02550","source_qa_id":"medium_divergent_branch_04560","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log... | |
medium_divergent_branch_02551 | The gene FBXW11 interacts with multiple other genes. One of these interactions is supported by evidence stating: 'One central step controlling p100 processing consists in the interaction of the E3 ubiquitin ligase β-TrCP with p100, thereby leading to its ubiquitinylation and subsequent either complete degradation or pa... | Nuclear factor NF-kappa-B p100 subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02551","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FBXW11 interacts with multiple other genes. One of these interactions is supported by evidence stating: 'One central step controlling p100 p... | |
medium_divergent_branch_02552 | Interleukin-4 production is enabled by more than one cell type. One of these cell types is described as a mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses. What is the parent class (is_a) of this specific cell type? | CD4-positive type I NK T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02552","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Interleukin-4 production is enabled by more than one cell type. One of these cell types is described as a mature NK T cell that predominantly secrete... | |
medium_divergent_branch_02553 | LYN interacts with multiple genes. One of these interaction partners is described in a study stating: 'We found that both Lyn and inositol 1,4,5-trisphosphate receptor (IP(3)R) associate with the distinct regions of a specific gene and that this gene promotes Lyn-mediated tyrosine phosphorylation of IP(3)R.' Which dise... | systemic lupus erythematosus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02553","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LYN interacts with multiple genes. One of these interaction partners is described in a study stating: 'We found that both Lyn and inositol 1,4,5-tris... | |
medium_divergent_branch_02555 | AMFR interacts with multiple proteins. One interaction partner is a transmembrane metastasis suppressor known as CD82, which is targeted for degradation by gp78. Which protein is encoded by the gene corresponding to this CD82 protein? | CD82 antigen | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02555","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AMFR interacts with multiple proteins. One interaction partner is a transmembrane metastasis suppressor known as CD82, which is targeted for degradat... | |
medium_divergent_branch_02556 | PPIB interacts with multiple genes. One interaction was identified through a yeast two-hybrid screen performed to delineate the mechanism of retrotranslocation, revealing an interaction between the target gene and cyclophilin B (CypB). Which disease is associated with this specific interacting partner? | hepatic encephalopathy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02556","source_qa_id":"medium_divergent_branch_05910","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PPIB interacts with multiple genes. One interaction was identified through a yeast two-hybrid scr... | |
medium_divergent_branch_02557 | MAP3K1 interacts with multiple genes. One interaction is supported by evidence stating that 14-3-3 proteins also interacted with MEKK1 and MEKK2, but not MEKK4. Which disease is associated with the gene identified by this specific evidence? | renal cell carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02557","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K1 interacts with multiple genes. One interaction is supported by evidence stating that 14-3-3 proteins also interacted with MEKK1 and MEKK2, but... | |
medium_divergent_branch_02558 | KIRREL1 forms binding interactions with multiple genes. One specific interaction is supported by evidence stating: 'Both native and recombinant Neph1 associate with each other as dimers and multimers and interact with nephrin via their extracellular segments.' Identify the gene that KIRREL1 binds to in this context, an... | CANX | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02558","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KIRREL1 forms binding interactions with multiple genes. One specific interaction is supported by evidence stating: 'Both native and recombinant Neph1... | |
medium_divergent_branch_02559 | The endomembrane system consists of multiple cellular components linked by part-whole relationships. One such component is described as a collection of membranous structures involved in intracellular transport, with main constituents including the endoplasmic reticulum, Golgi bodies, vesicles, the cell membrane, and th... | cell periphery | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02559","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The endomembrane system consists of multiple cellular components linked by part-whole relationships. One such component is described as a collection ... | |
medium_divergent_branch_02560 | GATA1 interacts with multiple proteins. One specific interaction involves a protein that, upon p38-dependent phosphorylation, translocates to the nucleus, binds to GATA-1, and triggers its ubiquitination and proteasomal degradation. Which protein corresponds to this description? | Heat shock protein beta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02560","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA1 interacts with multiple proteins. One specific interaction involves a protein that, upon p38-dependent phosphorylation, translocates to the nuc... | |
medium_divergent_branch_02561 | Tracheobronchial chondrocytes are components of specific anatomical structures. One such structure is characterized by hyaline cartilaginous supports that form irregular rings in larger bronchi and small plates in smaller bronchi, with the amount of cartilage decreasing until it is absent in the smallest bronchioles. W... | lower respiratory tract cartilage | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02561","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Tracheobronchial chondrocytes are components of specific anatomical structures. One such structure is characterized by hyaline cartilaginous supports... | |
medium_divergent_branch_02562 | DLGAP4 interacts with multiple genes. One specific interaction is supported by evidence showing that nArgBP2 binds to the proline-rich region of SAPAP via its third SH3 domain and was co-immunoprecipitated with SAPAP from rat brain extracts. Which disease is associated with the gene involved in this specific interactio... | breast fibrocystic disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02562","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLGAP4 interacts with multiple genes. One specific interaction is supported by evidence showing that nArgBP2 binds to the proline-rich region of SAPA... | |
medium_divergent_branch_02563 | RPS6KB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'When inactive, S6K1 associates with the eIF3 complex, while the S6K1 activator mTOR/raptor does not.' Which protein, connected to RPS6KB1 via this specific interaction, is the gene that encodes the protein product described in ... | Eukaryotic translation initiation factor 3 subunit B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02563","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPS6KB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'When inactive, S6K1 associates with the eIF3 complex, wh... | |
medium_divergent_branch_02564 | The gene MYO18A is associated with multiple biological processes. One specific association is supported by evidence stating: 'We report that the Rac/Cdc42-binding kinase MRCK and myosin II-related MYO18A linked by the adaptor protein LRAP35a form a functional tripartite complex, which is responsible for the assembly of... | actin cytoskeleton organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02564","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene MYO18A is associated with multiple biological processes. One specific association is supported by evidence stating: 'We report that the Rac/... | |
medium_divergent_branch_02565 | MIR9-1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Increased expression of miR-9-5p abrogates TGF-β1-dependent myofibroblast phenotypic transformation.' Identify the biological process that is negatively regulated by the process linked to MIR9-1 via this... | myofibroblast differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02565","source_qa_id":"medium_divergent_branch_02062","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MIR9-1 is associated with multiple biological processes. One specific association is supported by... | |
medium_divergent_branch_02566 | SIM1 interacts with multiple genes. One of these interaction partners is reported to bind and positively regulate the transcriptional activity of SIM1, SIM2, NPAS4, and itself, while not interacting with AhR, HIF1α, or ARNT. Which cellular component is this specific interaction partner located in? | protein-containing complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02566","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIM1 interacts with multiple genes. One of these interaction partners is reported to bind and positively regulate the transcriptional activity of SIM... | |
medium_divergent_branch_02567 | CLASP2 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Together, these results provide evidence for involvement of the microtubule plus-end tracking protein CLASP2 in cytoskeleton-related mechanisms underlying neuronal polarity and interplay between microtub... | presynaptic cytoskeleton | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02567","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLASP2 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Together, these results provide ... | |
medium_divergent_branch_02568 | HSF1 interacts with multiple proteins. One interaction is characterized by the finding that 'Our experiments further show that HSF1 is physically associated with this partner in the cell and that such binding is enhanced by heat shock.' What is the name of the protein encoded by the gene corresponding to this interacti... | Heat shock factor protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02568","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HSF1 interacts with multiple proteins. One interaction is characterized by the finding that 'Our experiments further show that HSF1 is physically ass... | |
medium_divergent_branch_02569 | XIST regulates more than one cell type. Evidence for one of these regulatory connections states: 'The expression of lncRNA XIST in THP-1-differentiated macrophages was significantly increased in M2 macrophages than M1.' Which cell type, connected to XIST via a 'regulates' relationship, is described by this evidence? Id... | CD4-positive, alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02569","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"XIST regulates more than one cell type. Evidence for one of these regulatory connections states: 'The expression of lncRNA XIST in THP-1-differentiat... | |
medium_divergent_branch_02570 | The gene LACTB is associated with multiple biological processes. One association is supported by evidence stating: 'Its mechanism of action involves alteration of mitochondrial lipid metabolism and differentiation of breast cancer cells.' Identify the biological process linked to this specific association via an 'is a'... | regulation of primary metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02570","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene LACTB is associated with multiple biological processes. One association is supported by evidence stating: 'Its mechanism of action involves ... | |
medium_divergent_branch_02571 | DSG2 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence showing that knockdown of DSG2 in a human bone marrow endothelial cell line leads to reduced in vitro angiogenesis and the relocalization of actin and VE-cadherin away from cell ju... | protein localization to cell-cell junction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02571","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DSG2 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence showing t... | |
medium_divergent_branch_02573 | NFKBIA interacts with multiple proteins. One interaction partner is a cytoplasmic protein that specifically recognizes a sequence in the N-terminal domain of IkappaBalpha responsible for its cytoplasmic retention, and this partner interacts with both IkappaBalpha and IkappaBalpha/NF-kappaB complexes. Which protein is e... | Ras GTPase-activating protein-binding protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02573","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFKBIA interacts with multiple proteins. One interaction partner is a cytoplasmic protein that specifically recognizes a sequence in the N-terminal d... | |
medium_divergent_branch_02574 | The gene CACNA1C interacts with multiple partners. Experimental evidence, specifically coimmunoprecipitation and colocalization assays in cardiomyocytes and transfected cell lines, indicates that the Cav1.2 protein physically interacts with one of these partners. Which protein is encoded by the gene that interacts with... | Potassium voltage-gated channel subfamily E member 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02574","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CACNA1C interacts with multiple partners. Experimental evidence, specifically coimmunoprecipitation and colocalization assays in cardiomyocy... | |
medium_divergent_branch_02575 | RACK1 is associated with multiple biological processes. One association is supported by evidence that RACK1 promotes migration through interaction with RhoA and activation of the RhoA/Rho kinase pathway. Which biological process is positively regulated by the process linked to this specific evidence? | cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02575","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RACK1 is associated with multiple biological processes. One association is supported by evidence that RACK1 promotes migration through interaction wi... | |
medium_divergent_branch_02576 | IQGAP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Second, some effectors of Rac/Cdc42 (IQGAP2, MLK-3, PLD1), but not others (e.g. PAKs, POSH, WASP, Par-6, IRSp53), interacted with this protein in a GTP-dependent manner.' What is the name of the protein encoded by the gene corre... | Rho-related GTP-binding protein RhoG | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02576","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IQGAP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Second, some effectors of Rac/Cdc42 (IQGAP2, MLK-3, PLD1)... | |
medium_divergent_branch_02578 | The protein THTPA is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by experimental evidence stating: 'Transformed bacteria had a high isopropyl-beta-d-thiogalactopyranoside-inducible ThTPase activity.' Which molecular function, connected to the functi... | catalytic activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02578","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein THTPA is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by experiment... | |
medium_divergent_branch_02579 | GATAD2A interacts with multiple genes. One of these interaction partners was identified in a study using Affinity Capture-MS and Affinity Capture-Western, where researchers noted that all subunits of the NuRD complex were found among its interactors. Which biological process is this gene involved in? | negative regulation of transcription by RNA polymerase II | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02579","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATAD2A interacts with multiple genes. One of these interaction partners was identified in a study using Affinity Capture-MS and Affinity Capture-Wes... | |
medium_divergent_branch_02580 | RC3H2 interacts with multiple genes. One interaction partner is characterized by the following evidence: 'Degradation of roquin2 is dependent on B-cell receptor activation, and requires the integrity of the Tyr691 residue in roquin2 that is essential for its interaction with this partner.' Which biological process is t... | proteasome-mediated ubiquitin-dependent protein catabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02580","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RC3H2 interacts with multiple genes. One interaction partner is characterized by the following evidence: 'Degradation of roquin2 is dependent on B-ce... | |
medium_divergent_branch_02581 | DERL1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that a signal peptide peptidase forms a complex with the ERAD factor Derlin1 and the E3 ubiquitin ligase TRC8 to cleave the unfolded protein response (UPR) regulator XBP1u.' Which protein, encoded by the gene intera... | Signal peptide peptidase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02581","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DERL1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that a signal peptide peptidase forms a comp... | |
medium_divergent_branch_02582 | UBA52 interacts with multiple proteins. One interaction is supported by mass spectrometric and coimmunoprecipitation data indicating a profound association with a mitochondrial outer membrane channel protein in wild-type and Myc-α-synuclein overexpressed neuronal cells, as well as in the substantia nigra and striatal r... | Non-selective voltage-gated ion channel VDAC1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02582","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBA52 interacts with multiple proteins. One interaction is supported by mass spectrometric and coimmunoprecipitation data indicating a profound assoc... | |
medium_divergent_branch_02583 | Parathyroid hormone (PTH) interacts with multiple receptor proteins. One specific interaction is supported by evidence stating: 'The analog photocrosslinks specifically to the recombinant hPTH/PTHrP receptor stably transfected into human embryonic kidney cells (HEK-293/C-21 cells, approximately 400,000 receptors per ce... | Parathyroid hormone/parathyroid hormone-related peptide receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02583","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Parathyroid hormone (PTH) interacts with multiple receptor proteins. One specific interaction is supported by evidence stating: 'The analog photocros... | |
medium_divergent_branch_02584 | ERCC1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here we show that XPF/ERCC1 is stably associated with hRad52, a recombinational repair protein, in human cell-free extracts and that these factors interact directly via the N-terminal domain of hRad52 and the XPF protein.' ... | SUMO1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02584","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERCC1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here we show that XPF/ERCC1 is stably associated wit... | |
medium_divergent_branch_02585 | TAF12 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The results demonstrate the indispensability of the histone fold motifs of these two TAFs for mutual interaction.' Which protein, connected to TAF12 via this interaction, is encoded by the gene in question? | Transcription initiation factor TFIID subunit 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02585","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAF12 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The results demonstrate the indispensability of t... | |
medium_divergent_branch_02586 | The gene IKBKG interacts with multiple partners. One specific interaction is supported by evidence describing mutational analyses of the complex between the NZF1 domain of a specific E3 ubiquitin ligase and NEMO CC2-LZ domains, where NEMO mutations impaired linear ubiquitin recognition and suppressed NF-κB activation. ... | E3 ubiquitin-protein ligase RNF31 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02586","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IKBKG interacts with multiple partners. One specific interaction is supported by evidence describing mutational analyses of the complex betw... | |
medium_divergent_branch_02587 | VEGFC interacts with multiple proteins. One specific interaction is supported by evidence describing the crystal structure of VEGF-C bound to the high-affinity-binding site of a receptor tyrosine kinase, which consists of immunoglobulin homology domains D2 and D3. Which protein, encoded by the gene corresponding to thi... | Vascular endothelial growth factor receptor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02587","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VEGFC interacts with multiple proteins. One specific interaction is supported by evidence describing the crystal structure of VEGF-C bound to the hig... | |
medium_divergent_branch_02588 | The gene ACTN1 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stating that ACTN1 encodes α-actinin-1, a member of the actin-crosslinking protein superfamily that participates in the organization of the cytoskeleton. Which cellular co... | intracellular anatomical structure | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02588","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ACTN1 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence ... | |
medium_divergent_branch_02589 | RIG-I (DDX58) interacts with multiple genes. One interaction is supported by evidence stating: 'Mechanistically, RIG-I could compete with Speckle Type POZ protein (SPOP) to bind the target protein, leading to attenuation of the polyubiquitination and proteasomal degradation of the target protein.' Which disease is asso... | breast cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02589","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RIG-I (DDX58) interacts with multiple genes. One interaction is supported by evidence stating: 'Mechanistically, RIG-I could compete with Speckle Typ... | |
medium_divergent_branch_02590 | CARD11 interacts with multiple proteins. One specific interaction involves a region functioning as an inhibitory domain that controls the association of CARD11 with signaling cofactors, including Bcl10, a MAP3K family member, IKKgamma, and caspase-8, requiring both the caspase recruitment domain (CARD) and the coiled-c... | cardiospondylocarpofacial syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02590","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CARD11 interacts with multiple proteins. One specific interaction involves a region functioning as an inhibitory domain that controls the association... | |
medium_divergent_branch_02591 | TRIM13 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'The interaction between a nuclear receptor and Trim13 was confirmed by co-immunoprecipitation.' Which protein, connected to TRIM13 via this interaction, is encoded by the gene in question? | Nuclear receptor subfamily 4immunitygroup A member 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02591","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM13 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'The interaction between a nuclear receptor and ... | |
medium_divergent_branch_02592 | MIR182 is associated with multiple biological processes. One association is supported by evidence stating that 'miR‑182 overexpression potently inhibited SMC proliferation and migration under both basal conditions and under platelet-derived growth factor-BB stimulation.' Identify the biological process linked to this s... | vascular associated smooth muscle cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02592","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR182 is associated with multiple biological processes. One association is supported by evidence stating that 'miR‑182 overexpression potently inhib... | |
medium_divergent_branch_02593 | ATF6 interacts with multiple genes. One of these interaction partners is reported to interact with ATF6 and, in Tg-treated cells, can enhance ATF6 activity. Which disease is connected to this specific interacting gene through a biomarker relationship? | carcinoma of esophagus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02593","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATF6 interacts with multiple genes. One of these interaction partners is reported to interact with ATF6 and, in Tg-treated cells, can enhance ATF6 ac... | |
medium_divergent_branch_02594 | The gene ITGA3 interacts with multiple proteins. One of these interacting partners was identified through Western blotting analysis of affinity-purified proteins, which confirmed its association with integrins beta(1), alpha(3), and alpha(6) in the human endometrium. Which protein is encoded by the gene corresponding t... | CD9 antigen | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02594","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ITGA3 interacts with multiple proteins. One of these interacting partners was identified through Western blotting analysis of affinity-purif... | |
medium_divergent_branch_02595 | The gene CRYAB interacts with multiple other genes. One of these interacting partners is supported by evidence stating: 'Interaction between these two chaperones and formation of a complex are also indicated by NMR spectroscopy, size-exclusion chromatography and mass spectrometry.' Which protein is encoded by the gene ... | Alpha-synuclein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02595","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CRYAB interacts with multiple other genes. One of these interacting partners is supported by evidence stating: 'Interaction between these tw... | |
medium_divergent_branch_02596 | The gene FAS interacts with multiple partners. One specific interaction is supported by evidence stating: 'Herein, we identify a novel interaction partner of CD95, Kip1 ubiquitination-promoting complex protein 2 (KPC2), using an unbiased proteomic approach.' Identify the disease associated with the gene identified in t... | depressive disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02596","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FAS interacts with multiple partners. One specific interaction is supported by evidence stating: 'Herein, we identify a novel interaction pa... | |
medium_divergent_branch_02597 | STAM2 interacts with multiple proteins. One of these interaction partners is known to bind STAM2 at defined phosphotyrosine sites, a mechanism associated with the activity of a specific protein tyrosine phosphatase. Which protein, encoded by the gene connected to STAM2 via this specific interaction, is the subject of t... | Tyrosine-protein phosphatase non-receptor type 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02597","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STAM2 interacts with multiple proteins. One of these interaction partners is known to bind STAM2 at defined phosphotyrosine sites, a mechanism associ... | |
medium_divergent_branch_02598 | PARP1 is involved in multiple biological processes. One connection is supported by evidence stating: 'Our data suggest an induced fit mechanism via a multi-domain assembly cascade that drives SSB sensing and stimulates an interplay with the scaffold protein XRCC1 orchestrating subsequent DNA repair events.' Which biolo... | establishment of protein localization to chromosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02598","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PARP1 is involved in multiple biological processes. One connection is supported by evidence stating: 'Our data suggest an induced fit mechanism via a... | |
medium_divergent_branch_02599 | Angiotensinogen (AGT) interacts with multiple proteins. One specific interaction is supported by structural evidence describing a 4.4 Å crystal structure of the complex between human angiotensinogen and a specific protease, which reveals a conformational rearrangement making a cleavage site accessible. Which protein is... | Renin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02599","source_qa_id":"medium_divergent_branch_07298","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Angiotensinogen (AGT) interacts with multiple proteins. One specific interaction is supported by ... | |
medium_divergent_branch_02600 | ADAP1 interacts with multiple genes. One of these interaction partners is a member of the protein kinase C (PKC) family, characterized by the fact that all groups of PKC associate directly through their cysteine-rich domains. Which disease is associated with this specific gene via genomic alterations? | adult acute lymphoblastic leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02600","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAP1 interacts with multiple genes. One of these interaction partners is a member of the protein kinase C (PKC) family, characterized by the fact th... | |
medium_divergent_branch_02602 | ADRM1 interacts with multiple genes. One interaction is supported by evidence stating: 'In our attempt to further elucidate the function of the gene PRKN, we have identified the proteasomal ubiquitin receptor Rpn13/ADRM1 as a PRKN-interacting protein.' Which disease is connected to the gene identified in this specific ... | autosomal recessive juvenile Parkinson disease 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02602","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADRM1 interacts with multiple genes. One interaction is supported by evidence stating: 'In our attempt to further elucidate the function of the gene ... | |
medium_divergent_branch_02603 | MAP1LC3B interacts with multiple proteins. One of these interaction partners is described in evidence stating: 'Strikingly, in addition to ULK1 and ULK2, this protein and FIP200 interacted with human ATG8 proteins, all with strong preference for the GABARAP subfamily.' What is the name of the protein encoded by this in... | Autophagy-related protein 13 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02603","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP1LC3B interacts with multiple proteins. One of these interaction partners is described in evidence stating: 'Strikingly, in addition to ULK1 and U... | |
medium_divergent_branch_02604 | The gene TBCB interacts with multiple tubulin-related genes. One specific interaction is supported by evidence stating: 'Second, there is a failure of CCT-generated folding intermediates to stably interact with TBCB, one of the five tubulin chaperones (TBCA-E) that participate in the pathway leading to the de novo asse... | Tubulin alpha-1A chain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02604","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TBCB interacts with multiple tubulin-related genes. One specific interaction is supported by evidence stating: 'Second, there is a failure o... | |
medium_divergent_branch_02605 | NPHP1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We demonstrated the interaction of the protein encoded by NPHP4 with nephrocystin suggesting that these two proteins participate in a common signaling pathway.' Which disease is associated with the gene encoding the prot... | normal pressure hydrocephalus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02605","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NPHP1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We demonstrated the interaction of the protein en... | |
medium_divergent_branch_02606 | CFLAR interacts with multiple proteins. One interaction partner is described as a kinase that, along with Raf-1 and TNF-receptor associated factors 1 and 2, is recruited by Fas-recruited FLIP to activate NF-kappaB and Erk signaling pathways. Which protein is this interaction partner? | Receptor-interacting serine/threonine-protein kinase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02606","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CFLAR interacts with multiple proteins. One interaction partner is described as a kinase that, along with Raf-1 and TNF-receptor associated factors 1... | |
medium_divergent_branch_02607 | ERBIN interacts with multiple genes. One interaction partner is described as the protein kinase breakpoint cluster region, a known negative regulator of cell proliferation and oncogenic transformation, identified as an ERBIN ligand. Which cell type is enriched for this specific interaction partner? | gamma-delta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02607","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERBIN interacts with multiple genes. One interaction partner is described as the protein kinase breakpoint cluster region, a known negative regulator... | |
medium_divergent_branch_02609 | ESRRA interacts with multiple genes. One of these interacting partners has been shown to interact directly with ERRalpha in vivo and to deacetylate ERRalpha, thereby increasing its DNA binding affinity in vitro. Which cell type is enriched for this specific interacting partner? | eosinophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02609","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ESRRA interacts with multiple genes. One of these interacting partners has been shown to interact directly with ERRalpha in vivo and to deacetylate E... |
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