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medium_divergent_branch_02728 | KCTD5 interacts with multiple genes. One of these interacting partners has been experimentally shown to form hetero-oligomeric complexes with KCTD5, KCTD2, and itself. Which protein is encoded by this specific interacting gene? | BTB/POZ domain-containing protein KCTD17 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02728","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCTD5 interacts with multiple genes. One of these interacting partners has been experimentally shown to form hetero-oligomeric complexes with KCTD5, ... | |
medium_divergent_branch_02729 | The MIEF2 gene, which encodes the mitochondrial dynamics protein of 49 kDa (MID49), is associated with multiple biological processes. One specific association is supported by evidence linking MIEF2 to a process involving the regulation of mitochondrial structure. Which broader biological process is this specific proces... | regulation of organelle organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02729","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The MIEF2 gene, which encodes the mitochondrial dynamics protein of 49 kDa (MID49), is associated with multiple biological processes. One specific as... | |
medium_divergent_branch_02730 | UNC13B interacts with multiple proteins. One interaction is supported by evidence stating: 'We show here that Doc2 interacts with Munc13 both in a cell-free system and in intact PC12 cells during the high K+-induced Ca2+-dependent exocytosis.' Which protein, encoded by the gene corresponding to this specific interactio... | Double C2-like domain-containing protein alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02730","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UNC13B interacts with multiple proteins. One interaction is supported by evidence stating: 'We show here that Doc2 interacts with Munc13 both in a ce... | |
medium_divergent_branch_02731 | The gene ADORA2A is associated with multiple biological processes. One of these associations is supported by evidence indicating that blood pressure and heart rate were increased, as well as platelet aggregation. Which cell type is linked to this specific biological process via an 'enabled by cell' relationship? | blood cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02731","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ADORA2A is associated with multiple biological processes. One of these associations is supported by evidence indicating that blood pressure ... | |
medium_divergent_branch_02732 | The gene ZFPM2 (also known as FOG2) is implicated in multiple biological processes. Clinical evidence supports an association between ZFPM2 and Tetralogy of Fallot (TOF) or Double Outlet Right Ventricle (DORV). One of the biological processes involving ZFPM2 is directly linked to this clinical evidence. Which parent bi... | ventricular cardiac muscle tissue morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02732","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ZFPM2 (also known as FOG2) is implicated in multiple biological processes. Clinical evidence supports an association between ZFPM2 and Tetra... | |
medium_divergent_branch_02733 | The gene XIAP interacts with multiple other genes. One specific interaction partner is characterized by the following mechanism: Upon activation of NOD2, the C-terminal proline-rich domain (PRD) of a specific phosphatase interacts with this partner, thereby disrupting its interaction with RIP2 to decrease NF-κB signali... | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02733","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene XIAP interacts with multiple other genes. One specific interaction partner is characterized by the following mechanism: Upon activation of N... | |
medium_divergent_branch_02734 | PAWR interacts with multiple genes. One of these interacting partners was identified as a novel binding partner of Par-4, with evidence showing endogenous interaction mediated by the PRY-SPRY domain. Which disease is associated with this specific interacting gene? | vitiligo | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02734","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAWR interacts with multiple genes. One of these interacting partners was identified as a novel binding partner of Par-4, with evidence showing endog... | |
medium_divergent_branch_02735 | OTUD3 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'The regulatory relationship between OTU domain-containing protein 3 and the interaction partner was verified by Co-Immunoprecipitation, ubiquitination assay, and site-specific mutation experiments.' What is the name of ... | Class E basic helix-loop-helix protein 22 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02735","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OTUD3 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'The regulatory relationship between OTU domain-c... | |
medium_divergent_branch_02736 | VPS28 interacts with multiple proteins. One specific interaction involves ESCRT-II binding to the C-terminal domain of the ESCRT-I subunit VPS28 via a helix located immediately C-terminal to the GLUE domain of the interacting partner. Which disease is associated with this interacting partner? | lipoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02736","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VPS28 interacts with multiple proteins. One specific interaction involves ESCRT-II binding to the C-terminal domain of the ESCRT-I subunit VPS28 via ... | |
medium_divergent_branch_02737 | RPL26 interacts with multiple proteins. One specific interaction is characterized by the formation of a ternary complex involving RPL26, HDM2, and a tumor suppressor protein, which stabilizes the tumor suppressor protein by inhibiting the ubiquitin ligase activity of HDM2. Which protein is encoded by the gene correspon... | Cellular tumor antigen p53 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02737","source_qa_id":"medium_divergent_branch_06714","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"RPL26 interacts with multiple proteins. One specific interaction is characterized by the formatio... | |
medium_divergent_branch_02738 | ACSL4 interacts with multiple proteins. One specific interaction is described by the following evidence: 'Our results show that [interaction partner] senses the initial lipid peroxides and amplifies lipid peroxidation linked to ferroptosis through phosphorylation and activation of ACSL4.' Based on this description, whi... | Protein kinase C beta type | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02738","source_qa_id":"medium_divergent_branch_05185","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ACSL4 interacts with multiple proteins. One specific interaction is described by the following ev... | |
medium_divergent_branch_02739 | MLLT10 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'Here we report that h[protein] interacts with AF10, an MLL (mixed lineage leukemia) fusion partner involved in acute myeloid leukemia, through the OM-LZ region of AF10 required for MLL-AF10-mediated leukemogenes... | Histone-lysine N-methyltransferase, H3 lysine-79 specific | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02739","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MLLT10 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'Here we report that h[protein] interacts... | |
medium_divergent_branch_02740 | Levobupivacaine interacts with multiple drugs. One such interaction is supported by a study where patients received either normal saline, clonidine, or the interacting drug (8 mg) combined with 30 mL of 0.5% levobupivacaine. Which disease is the interacting drug indicated for? | acute otitis externa | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02740","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Levobupivacaine interacts with multiple drugs. One such interaction is supported by a study where patients received either normal saline, clonidine, ... | |
medium_divergent_branch_02743 | GOLGA2 interacts with multiple genes. One of these interaction partners was identified through co-immunoprecipitation experiments in NCI-N87 and BGC-823 cells, revealing an endogenous association with GM130. Which biological process is this specific interaction partner involved in? | regulation of DNA-templated transcription | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02743","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GOLGA2 interacts with multiple genes. One of these interaction partners was identified through co-immunoprecipitation experiments in NCI-N87 and BGC-... | |
medium_divergent_branch_02744 | SOX6 is associated with multiple biological processes. One association is supported by evidence stating: 'It is concluded that the SOX trio have a significantly lower expression in human MSCs than in chondrocytes and that the electroporation-mediated co-transfection of SOX trio enhances chondrogenesis and suppresses hy... | chondrocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02744","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX6 is associated with multiple biological processes. One association is supported by evidence stating: 'It is concluded that the SOX trio have a si... | |
medium_divergent_branch_02746 | MRGPRX2 is associated with multiple molecular functions. One of these functions is supported by evidence indicating that the receptor couples to both Gi and Gq signaling pathways in mast cells. Which molecular function, connected to this specific activity via an 'is a' relationship, is the correct target? | transmembrane signaling receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02746","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MRGPRX2 is associated with multiple molecular functions. One of these functions is supported by evidence indicating that the receptor couples to both... | |
medium_divergent_branch_02747 | LDB1 interacts with multiple proteins. One specific interaction involves a partner that, along with LMO4, binds to the ubiquitous nuclear adaptor protein LDB1 (also known as NLI or CLIM2). This adaptor associates with the LIM domains of LMO and LIM homeodomain proteins via its LIM interaction domain (LID). Which protei... | Rhombotin-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02747","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LDB1 interacts with multiple proteins. One specific interaction involves a partner that, along with LMO4, binds to the ubiquitous nuclear adaptor pro... | |
medium_divergent_branch_02748 | GLRX3 interacts with multiple genes. One of these interacting partners is described in literature as a novel 335-amino acid (37.5-kDa) protein termed PICOT (PKC-interacting cousin of thioredoxin), which interacts with PKCtheta. Which disease is associated with this specific interacting partner via a biomarker relations... | retinal detachment | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02748","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GLRX3 interacts with multiple genes. One of these interacting partners is described in literature as a novel 335-amino acid (37.5-kDa) protein termed... | |
medium_divergent_branch_02749 | The protein spartin (encoded by the SPG20 gene) interacts with multiple partners. One specific interaction is supported by co-immunoprecipitation experiments confirming that spartin binds to HSPA5, GRP75, and nucleolin. Which disease is associated with the gene encoding this specific interacting partner through genomic... | Parkinson disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02749","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein spartin (encoded by the SPG20 gene) interacts with multiple partners. One specific interaction is supported by co-immunoprecipitation exp... | |
medium_divergent_branch_02750 | WNT2B is associated with multiple biological processes. One association is supported by evidence showing that exposure to stromal cell layers expressing Wnt genes significantly increased the numbers of mixed colony-forming units (CFU-MIX), CFU-granulocyte macrophage (CFU-GM), and burst-forming units-erythroid (BFU-E) c... | stem cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02750","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT2B is associated with multiple biological processes. One association is supported by evidence showing that exposure to stromal cell layers express... | |
medium_divergent_branch_02753 | PAX6 interacts with multiple genes. One of these interacting partners has been shown to bind directly to Kap13, a finding confirmed by in vitro assays with recombinant proteins and by coimmunoprecipitation in vivo. Which disease is associated with genomic alterations in this specific interacting partner? | childhood onset asthma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02753","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAX6 interacts with multiple genes. One of these interacting partners has been shown to bind directly to Kap13, a finding confirmed by in vitro assay... | |
medium_divergent_branch_02754 | MIR15B is associated with multiple biological processes. One association is supported by evidence that overexpression of miR-15b suppresses INSR protein expression by targeting its 3' untranslated region, thereby impairing insulin signaling and glycogen synthesis in hepatocytes. Which biological process is negatively r... | cellular response to insulin stimulus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02754","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR15B is associated with multiple biological processes. One association is supported by evidence that overexpression of miR-15b suppresses INSR prot... | |
medium_divergent_branch_02755 | ABCB6 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'Here we show that ABCB6 is a glycoprotein present in the membrane of mature erythrocytes and in exosomes released from reticulocytes during the final steps of erythroid maturation.... | extracellular space | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02755","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABCB6 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'Here we s... | |
medium_divergent_branch_02756 | The gene BCL2L11 interacts with multiple partners. One interaction is supported by evidence stating: 'Herein, with the help of a specific Hsp70/Bim disruptor and Om45-GFP processing assay, we illustrated that ectopic BimEL is able to promote mitophagy through Hsp70/Bim interaction in yeast, where Bax/Bak is absent.' Wh... | Heat shock 70 kDa protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02756","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene BCL2L11 interacts with multiple partners. One interaction is supported by evidence stating: 'Herein, with the help of a specific Hsp70/Bim d... | |
medium_divergent_branch_02757 | CD274 (PD-L1) interacts with multiple genes. One of these interacting partners is described as competing with the E3 ubiquitin ligase HUWE1 to bind PD-L1, thereby inhibiting its polyubiquitination at lysine 281 within the endoplasmic reticulum. Which biological process is this specific interacting partner involved in? | ERAD pathway | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02757","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD274 (PD-L1) interacts with multiple genes. One of these interacting partners is described as competing with the E3 ubiquitin ligase HUWE1 to bind P... | |
medium_divergent_branch_02758 | BVES is associated with multiple biological processes. One of these processes is linked to POPDC1, which is described as an essential regulator of the structure and function of cardiac and skeletal muscle. Which biological process is a part of the process associated with POPDC1? | skeletal muscle organ development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02758","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BVES is associated with multiple biological processes. One of these processes is linked to POPDC1, which is described as an essential regulator of th... | |
medium_divergent_branch_02759 | KLHL8 interacts with multiple genes. One of these interaction partners is supported by evidence showing that mammalian rapsyn was ubiquitinated by a CUL3/KLHL8-containing E3 ligase in vitro, and that knockdown of KLHL-8 (a mammalian KEL-8 homolog) inhibited rapsyn ubiquitination in vivo, implying evolutionary conservat... | 43 kDa receptor-associated protein of the synapse | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02759","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KLHL8 interacts with multiple genes. One of these interaction partners is supported by evidence showing that mammalian rapsyn was ubiquitinated by a ... | |
medium_divergent_branch_02760 | TLE1 interacts with multiple genes. One of these interacting partners is described as recruiting both the Groucho-related corepressor TLE1 and the N-CoR/Sin3/HDAC complex on distinct domains, with its in vivo repressor functions requiring specific recruitment of TLE1, which shows a spatial and temporal pattern of coexp... | Homeobox expressed in ES cells 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02760","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TLE1 interacts with multiple genes. One of these interacting partners is described as recruiting both the Groucho-related corepressor TLE1 and the N-... | |
medium_divergent_branch_02762 | USP36 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating that USP36 localizes to nucleoli through its C-terminal region, which contains basic amino acid stretches. Which cellular component is connected to this specific localizatio... | nuclear lumen | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02762","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP36 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating th... | |
medium_divergent_branch_02763 | KLHL3 interacts with multiple genes. One specific interaction is characterized by the determination of the crystal structure of the KLHL3 Kelch domain in complex with a peptide from the interacting partner. Which disease is associated with this specific interacting partner? | Prieto syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02763","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KLHL3 interacts with multiple genes. One specific interaction is characterized by the determination of the crystal structure of the KLHL3 Kelch domai... | |
medium_divergent_branch_02764 | CTCFL interacts with multiple genes. One interaction is supported by evidence stating: 'This work identifies SET1A, an H3K4 methyltransferase, and a cochaperone recruiter, as binding partners for BORIS, and these proteins bind to the upstream promoter regions of two well-characterized procarcinogenic genes, Myc and BRC... | B-cell chronic lymphocytic leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02764","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CTCFL interacts with multiple genes. One interaction is supported by evidence stating: 'This work identifies SET1A, an H3K4 methyltransferase, and a ... | |
medium_divergent_branch_02765 | Human mastadenovirus C downregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of -1.223 and an adjusted p-value of 0.03813. Which biological process is the gene associated with this specific statistical evidence involved in? | endothelial cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02765","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human mastadenovirus C downregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of -1.223 and an adjuste... | |
medium_divergent_branch_02766 | FHL3 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show here that a Kruppel-like factor also recruits the four and a half LIM domain protein FHL3.' Which protein, connected to FHL3 via this specific interaction evidence, is encoded by the gene in question? | Krueppel-like factor 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02766","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FHL3 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show here that a Kruppel-like factor also recruits the f... | |
medium_divergent_branch_02768 | UBE2B interacts with multiple proteins. One interaction is supported by evidence stating: 'Using yeast two-hybrid analysis we identified HHR6 as a protein binding partner and confirmed this using immunoprecipitation studies.' Which protein, connected to UBE2B via this specific evidence, is encoded by the gene in questi... | Zinc finger MYM-type protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02768","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2B interacts with multiple proteins. One interaction is supported by evidence stating: 'Using yeast two-hybrid analysis we identified HHR6 as a pr... | |
medium_divergent_branch_02769 | The gene POLN interacts with multiple proteins. One interaction is supported by evidence stating that a mutant of the interacting protein, harboring a Serine to Alanine substitution at position 409, was compromised for Polη association and did not efficiently redistribute Polη to nuclear foci or promote the interaction... | E3 ubiquitin-protein ligase RAD18 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02769","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene POLN interacts with multiple proteins. One interaction is supported by evidence stating that a mutant of the interacting protein, harboring ... | |
medium_divergent_branch_02770 | HES1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that Hrt2 and Hes1 interact with RBP-Jkappa to negatively regulate Notch-dependent activation of Hrt and Hes expression.' What is the full protein name encoded by the gene corresponding to RBP-Jkappa? | Recombining binding protein suppressor of hairless | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02770","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HES1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that Hrt2 and Hes1 interact with RBP-Jkappa to... | |
medium_divergent_branch_02771 | RAB11A is associated with multiple biological processes. One association is supported by evidence stating: 'The closely related GTPases Rab11 and Rab25 promote cell migration by regulating vesicular transport and recycling of surface receptors.' Identify the biological process connected to the process supported by this... | vesicle-mediated transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02771","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB11A is associated with multiple biological processes. One association is supported by evidence stating: 'The closely related GTPases Rab11 and Rab... | |
medium_divergent_branch_02772 | The gene ATG3 is reported to interact with multiple partners. One specific interaction is supported by evidence stating: 'Furthermore, hApg3p coimmunoprecipitates with hApg12p, and the overexpression of hApg3p facilitates the formation of the GFPhApg12p.thApg5p conjugate, suggesting that hApg3p cross-talks with the hAp... | Ubiquitin-like protein ATG12 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02772","source_qa_id":"medium_divergent_branch_06512","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene ATG3 is reported to interact with multiple partners. One specific interaction is support... | |
medium_divergent_branch_02773 | The gene PROC interacts with multiple partners via binding. One specific interaction involves the inhibition of activated protein C (APC) by a serine protease inhibitor, a process accompanied by the formation of enzyme-inhibitor complexes. Which protein is encoded by the gene that binds to PROC in this specific inhibit... | Plasma serine protease inhibitor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02773","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PROC interacts with multiple partners via binding. One specific interaction involves the inhibition of activated protein C (APC) by a serine... | |
medium_divergent_branch_02774 | ZBTB2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Intriguingly, we identified all the subunits of the NuRD complex among the ZBTB2 interactors.' Which protein, connected to ZBTB2 via this specific interaction, is the gene that encodes the protein product associated with this con... | Histone-binding protein RBBP4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02774","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZBTB2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Intriguingly, we identified all the subunits of the NuRD c... | |
medium_divergent_branch_02775 | HTRA2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Yeast two-hybrid analysis revealed that the C-terminus of the interacting partner interacts with high temperature requirement A2 (HTRA2), a serine protease with a critical role in apoptosis.' Based on this specific evidence... | cell surface | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02775","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HTRA2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Yeast two-hybrid analysis revealed that the C-termin... | |
medium_divergent_branch_02776 | SIK2 interacts with multiple proteins. One specific interaction is distinguished by the fact that SIK2 is the only AMP-activated kinase (AMPK) family member known to interact with protein phosphatase 2 (PP2A). Which protein, connected to SIK2 via this specific interaction, is encoded by the gene in question? | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02776","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIK2 interacts with multiple proteins. One specific interaction is distinguished by the fact that SIK2 is the only AMP-activated kinase (AMPK) family... | |
medium_divergent_branch_02777 | LIPE interacts with multiple genes. One of these interactions is specifically supported by evidence stating that HSL closely, if not directly, interacts with a perilipin family protein, as indicated by fluorescence resonance energy transfer (FRET) and bimolecular fluorescence complementation (BiFC) experiments. Which d... | adult liposarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02777","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LIPE interacts with multiple genes. One of these interactions is specifically supported by evidence stating that HSL closely, if not directly, intera... | |
medium_divergent_branch_02778 | The gene AGTR1 interacts with multiple partners. One interaction is supported by evidence showing that in HEK-293 cells expressing hemagglutinin-tagged AT1aR, angiotensin stimulation triggered binding to the receptor and internalization of AT1aR-beta-arrestin complexes. Which disease is associated with the gene identif... | leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02778","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AGTR1 interacts with multiple partners. One interaction is supported by evidence showing that in HEK-293 cells expressing hemagglutinin-tagg... | |
medium_divergent_branch_02779 | MIR92A1 is associated with multiple biological processes. One association is supported by evidence that forced overexpression of miR-92a in endothelial cells blocked angiogenesis in vitro and in vivo. Which biological process, connected to the process supported by this evidence, is the target of a 'negatively regulates... | blood vessel endothelial cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02779","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR92A1 is associated with multiple biological processes. One association is supported by evidence that forced overexpression of miR-92a in endotheli... | |
medium_divergent_branch_02780 | APPL1 interacts with multiple genes. One of these interaction partners is known to interact with adiponectin receptors in mammalian cells, an interaction that is stimulated by adiponectin. Which disease is associated with this specific interaction partner through genomic alterations? | coronary artery disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02780","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APPL1 interacts with multiple genes. One of these interaction partners is known to interact with adiponectin receptors in mammalian cells, an interac... | |
medium_divergent_branch_02781 | The gene C12orf57 is associated with multiple biological processes. One association is supported by evidence stating: 'Our data strongly implicate mutations in C12orf57 in the pathogenesis of a clinically distinct autosomal-recessive syndromic form of colobomatous microphthalmia.' Which biological process, connected to... | camera-type eye development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02781","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene C12orf57 is associated with multiple biological processes. One association is supported by evidence stating: 'Our data strongly implicate mu... | |
medium_divergent_branch_02783 | TCF7L2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this report we reveal that the evolutionary conserved [protein] functions as a TCF-4 interacting partner.' Which protein, encoded by the gene connected to TCF7L2 via this specific interaction, is the subject of this statement... | DAZ-associated protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02783","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TCF7L2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this report we reveal that the evolutionary conserved ... | |
medium_divergent_branch_02784 | GNG2 interacts with multiple proteins. One of these interaction partners is described as a member of the WD40 repeat protein family that directly binds free Gβγ in vitro and forms a complex with endogenous Gβγ in Jurkat T cells stimulated by the chemokine SDF1α. Which protein is encoded by the gene corresponding to thi... | WD repeat-containing protein 26 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02784","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNG2 interacts with multiple proteins. One of these interaction partners is described as a member of the WD40 repeat protein family that directly bin... | |
medium_divergent_branch_02785 | USP11 interacts with multiple proteins. One specific interaction is supported by evidence stating that the partner protein is cleaved by USP11 when monoubiquitinated, both in cells and in vitro. Which protein corresponds to this interaction partner? | DNA-dependent metalloprotease SPRTN | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02785","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP11 interacts with multiple proteins. One specific interaction is supported by evidence stating that the partner protein is cleaved by USP11 when m... | |
medium_divergent_branch_02786 | PTGES3 is reported to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We have identified the molecular chaperones p23 and Hsp90 as proteins that bind to the catalytic subunit of telomerase.' Which gene, linked to PTGES3 by this interaction, encodes the protein described in t... | Telomerase reverse transcriptase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02786","source_qa_id":"medium_divergent_branch_01700","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PTGES3 is reported to interact with multiple proteins. One specific interaction is supported by e... | |
medium_divergent_branch_02787 | IMPA1 interacts with multiple genes. One specific interaction is supported by in vitro studies using purified proteins, which demonstrated that the interacting partner bound to and activated IMPA1. Which disease is associated with this specific interacting partner through genomic alterations? | Crohn disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02787","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IMPA1 interacts with multiple genes. One specific interaction is supported by in vitro studies using purified proteins, which demonstrated that the i... | |
medium_divergent_branch_02788 | SSTR4 is associated with multiple molecular functions. One association is supported by evidence stating: 'We have previously shown that cytotoxicity leading to apoptosis was signaled solely via human (h) SSTR subtype 3, whereas the other four hSSTR subtypes initiated a cytostatic response that led to growth inhibition.... | neuropeptide receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02788","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SSTR4 is associated with multiple molecular functions. One association is supported by evidence stating: 'We have previously shown that cytotoxicity ... | |
medium_divergent_branch_02789 | TBX5 is associated with multiple biological processes. One of these processes is supported by evidence stating that the TBX5 transcription factor is expressed not only in the myocardium, but also throughout the embryonic epicardium and coronary vasculature. Which broader biological category, defined by an 'is a' relati... | animal organ development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02789","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TBX5 is associated with multiple biological processes. One of these processes is supported by evidence stating that the TBX5 transcription factor is ... | |
medium_divergent_branch_02790 | BCL2 is associated with multiple biological processes. One specific association is supported by evidence stating that Bcl-2 and related family members inhibit the death of neurons and other cells in response to pathogenic stimuli. Which cellular location is linked to this specific biological process via the 'occurs in'... | neuron | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02790","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL2 is associated with multiple biological processes. One specific association is supported by evidence stating that Bcl-2 and related family member... | |
medium_divergent_branch_02791 | The gene NSFL1C interacts with multiple partners. One interaction is supported by evidence stating: 'Now we have identified a novel essential factor for p97/p47-mediated membrane fusion, named [a specific protein], and show that it binds to the p97/p47/syntaxin5 complex and dissociates it via p97 catalyzed ATP hydrolys... | Deubiquitinating protein VCPIP1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02791","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NSFL1C interacts with multiple partners. One interaction is supported by evidence stating: 'Now we have identified a novel essential factor ... | |
medium_divergent_branch_02792 | STX1A interacts with multiple proteins. One interaction partner is characterized by evidence stating that Complexins bind weakly to syntaxin alone and not at all to synaptobrevin and SNAP-25, but strongly to the SNAP receptor-core complex composed of these three molecules. Which disease is associated with this specific... | intellectual disability | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02792","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STX1A interacts with multiple proteins. One interaction partner is characterized by evidence stating that Complexins bind weakly to syntaxin alone an... | |
medium_divergent_branch_02793 | ARHGAP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using glutathione S-transferase recombinant proteins, immunoprecipitation studies, and yeast two-hybrid assays, it was found that a specific protein and Cdc42GAP could form homo and hetero complexes via their conserved BCH doma... | BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02793","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARHGAP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using glutathione S-transferase recombinant proteins, im... | |
medium_divergent_branch_02794 | The gene CTTN interacts with multiple other genes. One specific interaction is supported by evidence showing that co-immunoprecipitation of the interacting partner with cortactin occurred at endogenous expression levels, was transiently induced by epidermal growth factor (EGF) treatment, and required the cortactin Src ... | CD2-associated protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02794","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CTTN interacts with multiple other genes. One specific interaction is supported by evidence showing that co-immunoprecipitation of the inter... | |
medium_divergent_branch_02795 | CCND1 interacts with multiple genes. One interaction is supported by evidence stating: 'Pulldown of ectopically expressed Cul1, the scaffold protein of the Skp-Cullin-F-box E3 ligase, in STG28-treated cells revealed an increased association of cyclin D1 with beta-TrCP, whereas no specific binding was noted with other F... | diabetic kidney disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02795","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCND1 interacts with multiple genes. One interaction is supported by evidence stating: 'Pulldown of ectopically expressed Cul1, the scaffold protein ... | |
medium_divergent_branch_02796 | NUDCD2 interacts with multiple genes. One of these interaction partners is stabilized by NudCL2. Which disease is associated with this specific interaction partner through genomic alterations? | T-cell prolymphocytic leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02796","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUDCD2 interacts with multiple genes. One of these interaction partners is stabilized by NudCL2. Which disease is associated with this specific inter... | |
medium_divergent_branch_02797 | SKP1 interacts with multiple genes. One such interaction is supported by evidence stating: 'Interestingly, inhibition of adipogenesis does not require the JmjC demethylase domain of a specific F-box protein, but it does require the F-box and leucine-rich repeat domains, which we show recruit a noncanonical polycomb rep... | neurodevelopmental disorder with congenital cardiac defects and variable renal and ocular abnormalities | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02797","source_qa_id":"medium_divergent_branch_06422","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SKP1 interacts with multiple genes. One such interaction is supported by evidence stating: 'Inter... | |
medium_divergent_branch_02798 | RSPO2 interacts with multiple proteins. One interaction is characterized by binding affinities measured in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay, where the affinity order for the leucine-rich repeat domains (LRR1-14) of the binding partner was reported as RSPO4 > the partner > RSPO3 > R... | Leucine-rich repeat-containing G-protein coupled receptor 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02798","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RSPO2 interacts with multiple proteins. One interaction is characterized by binding affinities measured in a time-resolved fluorescence resonance ene... | |
medium_divergent_branch_02799 | WNT4 is associated with multiple biological processes. One association is supported by evidence stating: 'These results indicated that Wnt-4 and Wnt-5a are oppositely affected by EMT, and down-regulation of Wnt-4 and up-regulation of Wnt-5a are possible markers of the malignant phenotype of human SCC.' Identify the bio... | mesenchymal cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02799","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT4 is associated with multiple biological processes. One association is supported by evidence stating: 'These results indicated that Wnt-4 and Wnt-... | |
medium_divergent_branch_02800 | MARCH5 is reported to interact with multiple genes. One specific interaction partner is distinguished by the following evidence: MITOL interacts with and ubiquitinates the mitochondrial form of this entity, but does not interact with its ER-associated form. Which gene is this interaction partner? | MFN2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02800","source_qa_id":"medium_divergent_branch_04802","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MARCH5 is reported to interact with multiple genes. One specific interaction partner is distingui... | |
medium_divergent_branch_02801 | ERCC3 (XPB) interacts with multiple proteins. One interaction partner is distinguished by evidence showing it interacts with XPB but not with other core TFIIH subunits in a two-hybrid assay. Which protein product is encoded by this specific interaction partner? | 26S proteasome regulatory subunit 8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02801","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERCC3 (XPB) interacts with multiple proteins. One interaction partner is distinguished by evidence showing it interacts with XPB but not with other c... | |
medium_divergent_branch_02802 | TXNIP interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we report that thioredoxin interacting protein (TXNIP), a member of the tumor suppressor family, interacts with hEcd and decreases MDM2-mediated p53 ubiquitination, leading to p53 stabilization and an increase in p53 activity.... | gout | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02802","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TXNIP interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we report that thioredoxin interacting protein (TXNIP),... | |
medium_divergent_branch_02803 | PRDX4 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified peroxiredoxin-4 (Prx-4) as a protein interacting with the beta isoform of the thromboxane A(2) receptor (TPbeta) by yeast two-hybrid analysis.' Which protein product is encoded by the gene corresponding to this spec... | Thromboxane A2 receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02803","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRDX4 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified peroxiredoxin-4 (Prx-4) as a protein interac... | |
medium_divergent_branch_02804 | EML4 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stating that EML4 is a protein that promotes the stability of the component in question. Which cellular component, connected to this specific component via the 'part of' relationshi... | microtubule cytoskeleton | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02804","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EML4 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stating th... | |
medium_divergent_branch_02805 | TTI2 interacts with multiple genes. One of these interaction partners is part of a complex that, in addition to the partner and TTI2, contains the Hsp90 chaperone; furthermore, inhibition of Hsp90 interferes with the interaction of Tel2 with PIKKs. Which disease is associated with this specific interaction partner? | neurodevelopmental disorder with microcephaly and movement abnormalities | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02805","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TTI2 interacts with multiple genes. One of these interaction partners is part of a complex that, in addition to the partner and TTI2, contains the Hs... | |
medium_divergent_branch_02806 | Titin (TTN) interacts with multiple proteins. One specific interaction is characterized by binding between the N-terminal Z-repeat region of titin and the C-terminal region of alpha-actinin. Which gene encodes the protein that engages in this specific interaction with titin? | Alpha-actinin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02806","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Titin (TTN) interacts with multiple proteins. One specific interaction is characterized by binding between the N-terminal Z-repeat region of titin an... | |
medium_divergent_branch_02807 | HCFC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show here that HCF-1 directly binds to the Myc-interacting protein Miz-1, a transcription factor that induces cell cycle arrest at G(1), in part by directly stimulating expression of the cyclin-dependent kinase inhibitor p15(I... | Zinc finger and BTB domain-containing protein 17 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02807","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HCFC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show here that HCF-1 directly binds to the Myc-interact... | |
medium_divergent_branch_02808 | The protein RHAG is associated with multiple molecular functions. One specific function is supported by evidence stating: 'Our results are the first evidence that the human erythroid RhAG increases the transport of both NH3 and NH4+.' Which molecular function, connected to this specific activity via an 'is_a' relations... | channel activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02808","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein RHAG is associated with multiple molecular functions. One specific function is supported by evidence stating: 'Our results are the first ... | |
medium_divergent_branch_02809 | COL17A1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In this study, we have delineated the molecular interaction between these two proteins utilizing the yeast two-hybrid system, which was confirmed by an in vitro protein-protein interaction assay.' Which protein product... | Catenin delta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02809","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COL17A1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'In this study, we have delineated the molecular... | |
medium_divergent_branch_02810 | The protein RECQL5 is associated with multiple biological processes. One association is supported by evidence stating: 'These results predict that RecQ5beta may have an important role in DNA metabolism and may also be related to a distinct genetic disease.' Identify the biological process described by this evidence. Th... | nucleic acid metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02810","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein RECQL5 is associated with multiple biological processes. One association is supported by evidence stating: 'These results predict that Re... | |
medium_divergent_branch_02811 | Interleukin-10 (IL10) is associated with multiple biological processes. One association is supported by structural evidence showing that IL-10 and IL-10Rα form a composite surface to engage the shared signaling receptor IL-10Rβ, enabling the design of partial agonists. Which biological process, connected to the process... | cellular response to cytokine stimulus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02811","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Interleukin-10 (IL10) is associated with multiple biological processes. One association is supported by structural evidence showing that IL-10 and IL... | |
medium_divergent_branch_02812 | TRIM31 interacts with multiple genes. One of these interactions is characterized by the partner protein interfering with TRIM31's binding to MAVS. Which gene is this partner? | USP14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02812","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM31 interacts with multiple genes. One of these interactions is characterized by the partner protein interfering with TRIM31's binding to MAVS. Wh... | |
medium_divergent_branch_02813 | MEF2D interacts with multiple proteins. One interaction is supported by evidence stating: 'It has been shown that nuclear factor of activated T cells (NFAT) interacts with MEF2D and enhances its transcriptional activity, offering a plausible mechanism of activation of MEF2D by calcineurin.' What is the name of the prot... | Nuclear factor of activated T-cells, cytoplasmic 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02813","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MEF2D interacts with multiple proteins. One interaction is supported by evidence stating: 'It has been shown that nuclear factor of activated T cells... | |
medium_divergent_branch_02814 | The gene GRIN2B interacts with multiple partners. One interaction is supported by evidence showing that a specific protein isoform, designated as entity 695, co-immunoprecipitated with assembled NR1-1a/NR2A and NR1-1a/NR2B NMDA receptors following expression in mammalian cells. Which protein is encoded by the gene corr... | Amyloid-beta precursor protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02814","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene GRIN2B interacts with multiple partners. One interaction is supported by evidence showing that a specific protein isoform, designated as ent... | |
medium_divergent_branch_02815 | PIP5K1C interacts with multiple proteins. One interaction is supported by evidence stating: 'However, binding of E-cadherin to Type I gamma phosphatidylinositol phosphate kinase (PIPKIγ), a protein required for recruitment of E-cadherin to adhesion sites, was blocked by O-GlcNAc glycosylation (O-GlcNAcylation).' Which ... | Cadherin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02815","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIP5K1C interacts with multiple proteins. One interaction is supported by evidence stating: 'However, binding of E-cadherin to Type I gamma phosphati... | |
medium_divergent_branch_02817 | FGF10 is implicated in multiple biological processes. One specific process is linked to clinical evidence stating that mutations in FGF10 are associated with ALSG and lacrimo-auriculo-dento-digital (LADD) syndrome, which are overlapping clinical entities. Identify the broader biological category that this specific proc... | gland development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02817","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF10 is implicated in multiple biological processes. One specific process is linked to clinical evidence stating that mutations in FGF10 are associa... | |
medium_divergent_branch_02818 | The gene EIF3F interacts with multiple partners. One specific interaction is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Identify the protein product encoded by the gene that corresponds to the CIF-1 protein mentioned in this evidence. | Eukaryotic translation initiation factor 3 subunit M | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02818","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EIF3F interacts with multiple partners. One specific interaction is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactiva... | |
medium_divergent_branch_02819 | HSF1 interacts with multiple genes. One of these interaction partners is described by the following evidence: 'In stressed cells, a heat shock protein enters the nucleus and, in the form of large oligomers, binds to HSF1 and induces its modification by SUMO-2/3 on lysine 298.' Which disease is associated with this inte... | lung carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02819","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HSF1 interacts with multiple genes. One of these interaction partners is described by the following evidence: 'In stressed cells, a heat shock protei... | |
medium_divergent_branch_02821 | The gene LPAR1 is associated with multiple biological processes. One association is supported by evidence stating that LPA signals via the ubiquitously expressed G protein-coupled receptors (GPCRs), LPA(1) and LPA(2), which are specific for LPA. Which biological process is a parent term (via an 'is a' relationship) of ... | signal transduction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02821","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene LPAR1 is associated with multiple biological processes. One association is supported by evidence stating that LPA signals via the ubiquitous... | |
medium_divergent_branch_02823 | RAB32 is associated with multiple cellular components via 'located in' relationships. One association is supported by evidence stating that silencing the BLOC-3 subunits Hps1 and Hps4 leads to the mislocalization of RAB32 and Rab38, along with reduced pigmentation. Which cellular component is connected to this specific... | chitosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02823","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB32 is associated with multiple cellular components via 'located in' relationships. One association is supported by evidence stating that silencing... | |
medium_divergent_branch_02824 | PPARG interacts with multiple genes. One specific interaction involves a partner whose binding to PPARG is reduced by Thiazolidinedione treatment, a mechanism suggested to explain how this partner represses PPARγ activity. Which disease is associated with this specific interacting partner through genomic alterations? | osteosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02824","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPARG interacts with multiple genes. One specific interaction involves a partner whose binding to PPARG is reduced by Thiazolidinedione treatment, a ... | |
medium_divergent_branch_02825 | CXCL8 is associated with multiple biological processes. One specific association is supported by evidence stating: 'We showed that PaCa-derived CXCL8 and fibroblast-derived CXCL12 cooperatively induced angiogenesis in vitro by promoting HUVEC proliferation, invasion, and tube formation.' Based on this evidence, which b... | circulating fibrocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02825","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CXCL8 is associated with multiple biological processes. One specific association is supported by evidence stating: 'We showed that PaCa-derived CXCL8... | |
medium_divergent_branch_02826 | GAB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In contrast, Gab1 activation depends on recruitment and phosphorylation by the tyrosine kinase receptor [REDACTED], with which it is constitutively associated.' Which protein, connected to GAB1 via this specific interaction eviden... | Macrophage-stimulating protein receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02826","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GAB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In contrast, Gab1 activation depends on recruitment and pho... | |
medium_divergent_branch_02827 | PLCG1 interacts with multiple genes. One specific interaction is supported by evidence that PLC-gamma is bound to CAIR-1/BAG-3 in unstimulated cells. Which disease is connected to this specific interacting partner through genomic alterations? | cardiomyopathy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02827","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLCG1 interacts with multiple genes. One specific interaction is supported by evidence that PLC-gamma is bound to CAIR-1/BAG-3 in unstimulated cells.... | |
medium_divergent_branch_02828 | PPARG interacts with multiple genes. One interaction is characterized by the statement: 'The requirements for TNIP1-PPAR interaction are characteristic for coactivators; however, TNIP1 partially decreases PPAR activity.' Which disease is associated with the gene described in this statement via a biomarker relationship? | arthritic joint disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02828","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPARG interacts with multiple genes. One interaction is characterized by the statement: 'The requirements for TNIP1-PPAR interaction are characterist... | |
medium_divergent_branch_02829 | DDX27 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Applying a mass spectrometric analysis, we identified the DEAD-box helicase DDX27 as stably associated factor of the PeBoW-complex.' Which gene, connected to DDX27 via this specific interaction, is subsequently linked to a... | WDR18 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02829","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDX27 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Applying a mass spectrometric analysis, we identifi... | |
medium_divergent_branch_02830 | ARHGEF12 interacts with multiple proteins. One interaction involves a complex that targets a PDZ-Rho guanine nucleotide exchange factor (RhoGEF), which is abundantly expressed in the brain, for ubiquitin-dependent proteolysis. This process restricts RhoA activity and facilitates growth cone spreading and neurite outgro... | Cullin-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02830","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARHGEF12 interacts with multiple proteins. One interaction involves a complex that targets a PDZ-Rho guanine nucleotide exchange factor (RhoGEF), whi... | |
medium_divergent_branch_02831 | DAZ1 interacts with multiple proteins. One of these interaction partners is supported by evidence stating that DAZAP1 and DAZAP2 bind similarly to both DAZ and this partner through the DAZ repeats. Which protein is encoded by the gene corresponding to this interaction partner? | Deleted in azoospermia-like | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02831","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DAZ1 interacts with multiple proteins. One of these interaction partners is supported by evidence stating that DAZAP1 and DAZAP2 bind similarly to bo... | |
medium_divergent_branch_02833 | PRKACA interacts with multiple proteins. One interaction is supported by evidence stating: 'Although neither VCP nor p47 interact directly with PKA, we found that this protein binds and phosphorylates the catalytic subunit of PKA at T197.' What is the name of the mitochondrial serine/threonine-protein kinase encoded by... | Serine/threonine-protein kinase PINK1, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02833","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKACA interacts with multiple proteins. One interaction is supported by evidence stating: 'Although neither VCP nor p47 interact directly with PKA, ... | |
medium_divergent_branch_02834 | The gene ACTR6 is associated with multiple biological processes. One of these associations is supported by evidence that the protein ARP6 influences the structure and function of the nucleolus. Which broader biological category, defined by an 'is a' relationship, encompasses the specific process linked to this nucleola... | nucleus organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02834","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ACTR6 is associated with multiple biological processes. One of these associations is supported by evidence that the protein ARP6 influences ... | |
medium_divergent_branch_02835 | FBXW4 interacts with multiple proteins. One interaction is supported by evidence stating: 'To begin to characterize the biochemical function of Fbxw4, we used proteomic analysis to demonstrate that Fbxw4 interacts with Skp1 (SKP1), Cullin1 (CUL1), Ring-box1 (RBX1) and all components of the COP9 signalosome.' Which prot... | COP9 signalosome complex subunit 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02835","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXW4 interacts with multiple proteins. One interaction is supported by evidence stating: 'To begin to characterize the biochemical function of Fbxw4... | |
medium_divergent_branch_02836 | VPS33B interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Instead, we identified that VPS33B interacts directly with this protein, a member of the CCC complex.' Which protein, connected to VPS33B via this interaction, is encoded by the gene in question? | Coiled-coil domain-containing protein 22 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02836","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VPS33B interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Instead, we identified that VPS33B interacts dir... | |
medium_divergent_branch_02837 | ST7 interacts with multiple proteins. One specific interaction evidence states: 'Use of the yeast two-hybrid system to identify proteins that associate with ST7's cytoplasmic domain revealed that this domain interacts with three proteins involved in signal transduction and/or endocytosis, viz., receptor for activated p... | Zinc finger FYVE domain-containing protein 9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02837","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ST7 interacts with multiple proteins. One specific interaction evidence states: 'Use of the yeast two-hybrid system to identify proteins that associa... | |
medium_divergent_branch_02838 | KEAP1 interacts with multiple proteins. One of these interaction partners is described as assembling into a functional E3 ubiquitin ligase complex alongside Cul3 and the partner itself, a complex that targets multiple lysine residues in the N-terminal Neh2 domain of Nrf2 for ubiquitin conjugation both in vivo and in vi... | E3 ubiquitin-protein ligase RBX1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02838","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KEAP1 interacts with multiple proteins. One of these interaction partners is described as assembling into a functional E3 ubiquitin ligase complex al... | |
medium_divergent_branch_02839 | RBBP8 interacts with multiple genes. One of these interacting partners has been shown to interact with and ubiquitinate CtIP at its N-terminal lysine residues. Which disease is associated with this specific interacting partner? | cerebral infarction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02839","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RBBP8 interacts with multiple genes. One of these interacting partners has been shown to interact with and ubiquitinate CtIP at its N-terminal lysine... |
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