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medium_divergent_branch_02840 | SLC26A6 is associated with multiple molecular functions. One specific function is supported by evidence stating that SLC26A6, a plasma membrane Cl-/HCO3- exchanger with a suggested role in pancreatic HCO3- secretion, was found to bind the cytoplasmic enzyme CAII. Which molecular function, connected to this specific fun... | transmembrane transporter activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02840","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLC26A6 is associated with multiple molecular functions. One specific function is supported by evidence stating that SLC26A6, a plasma membrane Cl-/H... | |
medium_divergent_branch_02841 | ADAM8 is involved in multiple biological processes. One such process is supported by evidence that ADAM8-dependent, soluble CD23 release requires proteolytically active ADAM8, and a physical association between ADAM8 and the membrane-bound form of CD23 was observed. Which biological process is a parent term (is_a) of t... | secretion by cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02841","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAM8 is involved in multiple biological processes. One such process is supported by evidence that ADAM8-dependent, soluble CD23 release requires pro... | |
medium_divergent_branch_02843 | COL1A1 interacts with multiple genes. One interaction is supported by evidence stating: 'All radiolabeled PDGF isoforms specifically interacted with type I, II, III, IV, V, and VI collagens (preferential binding to types III, I, VI, and IV) and their constituent chains, either when immobilized on polystyrene or blotted... | classic familial adenomatous polyposis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02843","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COL1A1 interacts with multiple genes. One interaction is supported by evidence stating: 'All radiolabeled PDGF isoforms specifically interacted with ... | |
medium_divergent_branch_02844 | ACLY interacts with multiple proteins. One specific interaction involves an adaptor protein from the Kelch-like family (specifically member 25) that facilitates the ubiquitination and degradation of ACLY. Which protein, connected to ACLY via this interaction, is encoded by the gene in question? | Kelch-like protein 25 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02844","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACLY interacts with multiple proteins. One specific interaction involves an adaptor protein from the Kelch-like family (specifically member 25) that ... | |
medium_divergent_branch_02845 | The gene SCN5A is associated with multiple biological processes. One association is supported by evidence stating: 'The human cardiac sodium channel Na(v)1.5 encoded by the SCN5A gene plays a critical role in cardiac excitability and the propagation of action potentials.' Which biological process, connected to the proc... | cardiac muscle cell action potential involved in contraction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02845","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SCN5A is associated with multiple biological processes. One association is supported by evidence stating: 'The human cardiac sodium channel ... | |
medium_divergent_branch_02846 | CYTH2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation studies revealed that ARNO (a guanine nucleotide exchange factor for ARF6) and ARF6 formed complexes preferentially with activated Galpha(q) compared to non-activated Galpha(q).' Which protein product is en... | Guanine nucleotide-binding protein G(q) subunit alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02846","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CYTH2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation studies revealed that ARNO (a guani... | |
medium_divergent_branch_02847 | TNKS interacts with multiple proteins. One of these interaction partners functions as a substrate decoy that hijacks substrate binding sites on TNKS to prevent AXIN1 PARylation and degradation. Which protein is encoded by the gene corresponding to this specific interaction partner? | P antigen family member 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02847","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNKS interacts with multiple proteins. One of these interaction partners functions as a substrate decoy that hijacks substrate binding sites on TNKS ... | |
medium_divergent_branch_02848 | SUMO3 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'We show here that the protein interacts with and is covalently modified by the ubiquitin-like proteins SUMO-1 and SUMO-2/3.' What is the name of the enzyme encoded by the gene corresponding to this interaction partner? | G/T mismatch-specific thymine DNA glycosylase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02848","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SUMO3 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'We show here that the protein interacts with and... | |
medium_divergent_branch_02849 | The biological process 'regulation of sperm capacitation' is defined as any process that modulates the frequency, rate, or extent of sperm capacitation. This process is a subtype of which broader biological process? | regulation of biological process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02849","source_qa_id":"medium_divergent_branch_00022","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of sperm capacitation' is defined as any process that modulate... | |
medium_divergent_branch_02850 | IGF2 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'With a single change at these sites to the nonconserved glycine there was a notable decrease in binding. A greater reduction was seen when both L80 and L81 were substituted with glycine, and complete loss of aff... | Insulin-like growth factor-binding protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02850","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGF2 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'With a single change at these sites to t... | |
medium_divergent_branch_02851 | CDKN1B (p27) interacts with multiple proteins. One specific interaction is characterized by the finding that the phosphorylated Thr-187-Pro motif in p27(Kip1) serves as a key binding site for the interacting partner. Which disease is associated with this specific interacting partner via a biomarker relationship? | malignant pancreatic neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02851","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDKN1B (p27) interacts with multiple proteins. One specific interaction is characterized by the finding that the phosphorylated Thr-187-Pro motif in ... | |
medium_divergent_branch_02852 | IL1R1 interacts with multiple genes. One of these interacting partners is described in a study noting that its association with TAK1 and its association with the IL-1 receptor I were significantly suppressed. Which disease is associated with this specific interacting gene? | bone resorption disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02852","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL1R1 interacts with multiple genes. One of these interacting partners is described in a study noting that its association with TAK1 and its associat... | |
medium_divergent_branch_02853 | SIAH1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We also found that SIAH1 interacts with this protein and promotes ubiquitination and proteasomal degradation of this protein.' Which protein, connected to SIAH1 via this interaction, is encoded by the gene in question? | Serine/threonine-protein kinase PINK1, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02853","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIAH1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We also found that SIAH1 interacts with this prot... | |
medium_divergent_branch_02854 | West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.415 and an adjusted p-value of 0.0461. Which disease is associated with that selected gene? | breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02854","source_qa_id":"medium_divergent_branch_03613","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log... | |
medium_divergent_branch_02855 | Human gammaherpesvirus 4 downregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of -1.415 and an adjusted p-value of 0.03107 in gamma delta T-lymphocytes. Which biological process is the gene corresponding to this specific evidence involved in? | glycosaminoglycan biosynthetic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02855","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human gammaherpesvirus 4 downregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of -1.415 and an adjus... | |
medium_divergent_branch_02856 | The gene SPAST is associated with multiple molecular functions. One specific function is supported by evidence stating: 'Using purified components, we also show that Spastin interacts directly with microtubules and is sufficient for severing.' For this specific molecular function, what is the primary input? | microtubule | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02856","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SPAST is associated with multiple molecular functions. One specific function is supported by evidence stating: 'Using purified components, w... | |
medium_divergent_branch_02857 | WNT7B is associated with multiple biological processes. One specific process is supported by evidence stating: 'However, proliferation was significantly inhibited by the Wnt signaling antagonist, secreted frizzled related protein-1 (sFRP-1). In addition, anti-Wnt1 and anti-Wnt2 antibodies attenuated MSC-CM-induced prol... | fibroblast | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02857","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT7B is associated with multiple biological processes. One specific process is supported by evidence stating: 'However, proliferation was significan... | |
medium_divergent_branch_02858 | VAV1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have used the yeast two-hybrid system to identify proteins that interact with Vav, a GDP/GTP exchange factor for the Rac-1 GTPase that plays an important role in cell signaling and oncogenic transformation.' Which protein, amon... | E3 ubiquitin-protein ligase CBL-B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02858","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VAV1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have used the yeast two-hybrid system to identify protei... | |
medium_divergent_branch_02859 | RBCK1 interacts with multiple genes. One of these interaction partners is described in literature as a protein whose stability is regulated by RBCK1 at the post-translational level via ubiquitination. Which biological process is this specific interaction partner involved in? | response to radiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02859","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RBCK1 interacts with multiple genes. One of these interaction partners is described in literature as a protein whose stability is regulated by RBCK1 ... | |
medium_divergent_branch_02860 | The gene KIFAP3 is reported to interact with multiple partners. One specific interaction is described by the following evidence: 'We show here that the gene product interacts with the kinesin superfamily (KIF) 3A-KIF3B proteins, microtubule plus-end-directed motor proteins, through an association with the kinesin super... | Adenomatous polyposis coli protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02860","source_qa_id":"medium_divergent_branch_04271","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene KIFAP3 is reported to interact with multiple partners. One specific interaction is descr... | |
medium_divergent_branch_02861 | EEF1G interacts with multiple genes. One of these interactions is supported by evidence stating: 'This peptide was responsible for the specific interaction of CRS with elongation factor-1gamma.' Which cell type is enriched in the gene corresponding to this specific interaction? | non-classical monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02861","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EEF1G interacts with multiple genes. One of these interactions is supported by evidence stating: 'This peptide was responsible for the specific inter... | |
medium_divergent_branch_02862 | The erythropoietin receptor (EPOR) interacts with multiple proteins. One specific interaction partner is characterized by the following mechanism: hydroxylation of EPOR is required for its binding to the beta domain of this partner, which subsequently leads to polyubiquitylation via an E3 ubiquitin ligase complex and i... | von Hippel-Lindau disease tumor suppressor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02862","source_qa_id":"medium_divergent_branch_00857","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The erythropoietin receptor (EPOR) interacts with multiple proteins. One specific interaction par... | |
medium_divergent_branch_02863 | The gene AP1G1 is known to interact with multiple proteins. One specific interaction is described by the following evidence: 'Recombinantly expressed [interacting protein] interacts directly with the gamma-appendage domain of AP-1, with the clathrin N-terminal domain through the peptide motif (423)LFDLM, with the gamma... | Clathrin interactor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02863","source_qa_id":"medium_divergent_branch_06207","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene AP1G1 is known to interact with multiple proteins. One specific interaction is described... | |
medium_divergent_branch_02864 | The gene CASQ2 is associated with multiple biological processes. One specific association is supported by experimental evidence stating: 'When expressed in rat myocytes, both mutants decreased the sarcoplasmic reticulum Ca2+-storing capacity and reduced the amplitude of I(Ca)-induced Ca2+ transients and of spontaneous ... | cardiac muscle tissue | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02864","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CASQ2 is associated with multiple biological processes. One specific association is supported by experimental evidence stating: 'When expres... | |
medium_divergent_branch_02865 | TP73 interacts with multiple genes. One of these interacting partners is identified by evidence stating that 'p34cdc2-cyclin B phosphorylates and associates with p73 in vivo'. Which disease is associated with this specific interacting gene through genomic alterations? | enterovirus infectious disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02865","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TP73 interacts with multiple genes. One of these interacting partners is identified by evidence stating that 'p34cdc2-cyclin B phosphorylates and ass... | |
medium_divergent_branch_02866 | TAF12 interacts with multiple genes. One specific interaction is supported by evidence describing the crystal structure of a complex formed by the interacting domains of two subunits of the general transcription factor TFIID: the human TATA binding protein-associated factors hTAF(II)135 and hTAF(II)20. Which disease is... | intellectual developmental disorder, autosomal dominant 73 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02866","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAF12 interacts with multiple genes. One specific interaction is supported by evidence describing the crystal structure of a complex formed by the in... | |
medium_divergent_branch_02867 | MAP4K1 interacts with multiple proteins. One interaction is supported by evidence stating: 'While KHS bound exclusively to Crk family proteins, HPK1 also interacted with both SH3 domains of this protein and weakly with Nck, but not with more than 25 other SH3 domains tested.' What is the name of the protein encoded by ... | Growth factor receptor-bound protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02867","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP4K1 interacts with multiple proteins. One interaction is supported by evidence stating: 'While KHS bound exclusively to Crk family proteins, HPK1 ... | |
medium_divergent_branch_02868 | SRSF1 interacts with multiple proteins. One interaction partner is characterized by the finding that deleting its N-terminal 174 amino acids abolishes binding to SF2/ASF and kinase activity, while ATP binding remains intact. This suggests that distinct domains are required for these functions. Which protein is encoded ... | DNA topoisomerase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02868","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SRSF1 interacts with multiple proteins. One interaction partner is characterized by the finding that deleting its N-terminal 174 amino acids abolishe... | |
medium_divergent_branch_02869 | UHRF2 interacts with multiple proteins. One specific interaction is characterized by evidence stating: 'Moreover, immunofluorescence staining and co-immunoprecipitation assay indicated that UHRF2 co-localized and interacted with H3K9ac in L02 and HepG2 cells and the plant homeodomain (PHD) finger domain was the key dom... | squamous cell lung carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02869","source_qa_id":"medium_divergent_branch_07089","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"UHRF2 interacts with multiple proteins. One specific interaction is characterized by evidence sta... | |
medium_divergent_branch_02870 | BMPR1B interacts with multiple proteins. One interaction partner is described as a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in association with type I receptors including BMPR-IB. Which protein, connected to BMPR1B via this interaction, is encoded by the gene in question? | Bone morphogenetic protein receptor type-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02870","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMPR1B interacts with multiple proteins. One interaction partner is described as a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 i... | |
medium_divergent_branch_02871 | ERICH6 is enriched in multiple cell types. One of these cell types shows a mean expression of 4.52 TPM, a z-score of 1.65, and a fold enrichment of 3.49. Which cell type is the precursor to the cell type matching these expression statistics? | pro-NK cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02871","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERICH6 is enriched in multiple cell types. One of these cell types shows a mean expression of 4.52 TPM, a z-score of 1.65, and a fold enrichment of 3... | |
medium_divergent_branch_02872 | IRF4 is associated with multiple biological processes. One association is supported by evidence stating: 'We demonstrate that stable expression of IRF-4 in Jurkat T cells not only leads to a strong enhancement in the synthesis of interleukin (IL)-2.' Identify the biological process that is positively regulated by the p... | interleukin-2 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02872","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRF4 is associated with multiple biological processes. One association is supported by evidence stating: 'We demonstrate that stable expression of IR... | |
medium_divergent_branch_02873 | MIR29B1 is associated with multiple biological processes. One association is supported by evidence that miR-29b acts as a potent suppressor of type I collagen at both mRNA and protein levels through direct binding to the Col1A1 3'UTR. Which biological process is negatively regulated by the specific process linked to th... | collagen biosynthetic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02873","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR29B1 is associated with multiple biological processes. One association is supported by evidence that miR-29b acts as a potent suppressor of type I... | |
medium_divergent_branch_02874 | Interplexiform cells are a subtype of a specific retinal neuron type. Evidence indicates this neuron type resides in the retinal inner nuclear layer and carries information from both the inner plexiform layer and the outer plexiform layer. Which anatomical structure is this neuron type part of? | central nervous system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02874","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Interplexiform cells are a subtype of a specific retinal neuron type. Evidence indicates this neuron type resides in the retinal inner nuclear layer ... | |
medium_divergent_branch_02875 | RFC2 interacts with multiple proteins. One interaction is supported by evidence describing the isolation of a stable complex composed of the p40, p37, and p36 subunits of hRFC from baculovirus-infected insect cells. Which protein, connected to RFC2 via this specific interaction, is encoded by the gene in question? | Replication factor C subunit 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02875","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RFC2 interacts with multiple proteins. One interaction is supported by evidence describing the isolation of a stable complex composed of the p40, p37... | |
medium_divergent_branch_02876 | PTK2 interacts with multiple proteins. One interaction is supported by evidence stating that expression of the Cas-binding proline-rich region 1 of FAK hindered the association of Cas with FAK and impaired the structural stability of sarcomeres. Which protein, connected to PTK2 via this specific interaction, is encoded... | Paxillin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02876","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTK2 interacts with multiple proteins. One interaction is supported by evidence stating that expression of the Cas-binding proline-rich region 1 of F... | |
medium_divergent_branch_02877 | The gene ZNF710 is enriched in multiple cell types. One specific cell type shows a mean expression of 5.83 TPM, a z-score of 2.03, and a fold enrichment of 4.17 for this gene. Which cell type does this specific cell develop from? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02877","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ZNF710 is enriched in multiple cell types. One specific cell type shows a mean expression of 5.83 TPM, a z-score of 2.03, and a fold enrichm... | |
medium_divergent_branch_02878 | SUV39H1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Coimmunoprecipitation experiments indicated that SUV39H1 can physically interact with HDAC1, -2 and -3, therefore suggesting that transcriptional repression by SUV39H1 could be the consequence of histone deacetylases recruitmen... | Histone deacetylase 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02878","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SUV39H1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Coimmunoprecipitation experiments indicated that SUV39H1... | |
medium_divergent_branch_02879 | TGFB3 interacts with multiple proteins. One interaction is supported by evidence stating: 'All three TGF-beta isoforms had rapid and similar association rates, but different dissociation rates, which resulted in the equilibrium dissociation constants being approximately 5pM for the TGF-beta1 and -beta3 isoforms, and 5n... | nervous system disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02879","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TGFB3 interacts with multiple proteins. One interaction is supported by evidence stating: 'All three TGF-beta isoforms had rapid and similar associat... | |
medium_divergent_branch_02880 | SASH1 is associated with multiple biological processes. One association is supported by evidence stating: 'This interaction fosters ubiquitination of TRAF6 and TAK1 and promotes LPS-induced NF-κB, JNK, and p38 activation, culminating in increased production of proinflammatory cytokines and increased LPS-induced endothe... | endothelial cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02880","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SASH1 is associated with multiple biological processes. One association is supported by evidence stating: 'This interaction fosters ubiquitination of... | |
medium_divergent_branch_02881 | Acetylcholinesterase (ACHE) is associated with multiple molecular functions. One specific function is supported by evidence stating: 'The results demonstrate that residue Trp-86 is the anionic site which binds, through cation-pi interactions, the quaternary ammonium of choline, and that of active center inhibitors such... | cation binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02881","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Acetylcholinesterase (ACHE) is associated with multiple molecular functions. One specific function is supported by evidence stating: 'The results dem... | |
medium_divergent_branch_02882 | ITGB2 interacts with multiple proteins. One interaction is supported by evidence stating: 'When leukocyte extracts were subjected to affinity chromatography on agarose to which residues 751-761 of the CD18 chain phosphorylated at Thr-758 were bound covalently, the only proteins that bound specifically were identified a... | 14-3-3 protein zeta/delta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02882","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITGB2 interacts with multiple proteins. One interaction is supported by evidence stating: 'When leukocyte extracts were subjected to affinity chromat... | |
medium_divergent_branch_02884 | RUNX1 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Immunoprecipitation analysis indicates that this region is required for AML1-MTG8 to form a stable complex with the interaction partner.' Which disease is associated with this specific interaction partner through g... | polycythemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02884","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RUNX1 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Immunoprecipitation analysis indicates that... | |
medium_divergent_branch_02885 | mmu-miR-486-5p regulates more than one cell type. Evidence indicates that miR-486-5p is highly expressed in mouse erythroid precursors. Which cell type, connected to the one supported by this expression evidence, is linked via the 'develops from' relationship? | reticulocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02885","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"mmu-miR-486-5p regulates more than one cell type. Evidence indicates that miR-486-5p is highly expressed in mouse erythroid precursors. Which cell ty... | |
medium_divergent_branch_02886 | The muscular coat of the vas deferens is classified as a specific type of anatomical structure. Evidence indicates that this entity is part of the vas deferens. Which broader anatomical category is the muscular coat of the vas deferens a subtype of? | layer of muscle tissue | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02886","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The muscular coat of the vas deferens is classified as a specific type of anatomical structure. Evidence indicates that this entity is part of the va... | |
medium_divergent_branch_02887 | CDK4 interacts with multiple genes. One specific interaction partner is supported by evidence stating that a zinc finger protein interacted with both Vav-1 and cyclin-dependent kinase 4 through two independent domains. Which molecular function is enabled by this specific interaction partner? | protein binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02887","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK4 interacts with multiple genes. One specific interaction partner is supported by evidence stating that a zinc finger protein interacted with both... | |
medium_divergent_branch_02888 | NR4A1 interacts with multiple proteins. One interaction is supported by evidence that Celastrol promotes Nur77 translocation from the nucleus to mitochondria, where it interacts with tumor necrosis factor receptor-associated factor 2, a scaffold protein and E3 ubiquitin ligase important for inflammatory signaling. Whic... | TNF receptor-associated factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02888","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NR4A1 interacts with multiple proteins. One interaction is supported by evidence that Celastrol promotes Nur77 translocation from the nucleus to mito... | |
medium_divergent_branch_02889 | PGAM1 interacts with multiple genes. One of these interacting partners has been shown to enhance the protein stability of phosphoglycerate mutase 1 (PGAM1) via direct interaction. Which gene is this interacting partner? | WDR20 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02889","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PGAM1 interacts with multiple genes. One of these interacting partners has been shown to enhance the protein stability of phosphoglycerate mutase 1 (... | |
medium_divergent_branch_02890 | PER1 interacts with multiple proteins. One specific interaction involves the nuclear translocation of mPER1 and mPER2, which requires physical binding to a partner protein. Which disease is associated with this partner protein through genomic alterations? | sleep-wake disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02890","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PER1 interacts with multiple proteins. One specific interaction involves the nuclear translocation of mPER1 and mPER2, which requires physical bindin... | |
medium_divergent_branch_02891 | NXF1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The Tap-RNA complex was shown to bind to three nucleoporins, Nup98, p62, and this protein, and these interactions were enhanced by Nxt1.' Which protein product is encoded by the gene corresponding to this interaction part... | E3 SUMO-protein ligase RanBP2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02891","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NXF1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The Tap-RNA complex was shown to bind to three nuc... | |
medium_divergent_branch_02893 | TICAM2 is associated with multiple molecular functions. One specific function is supported by evidence stating that TICAM-2 acts as a scaffold protein and activates TIR domain-containing adaptor molecule-1 (TICAM-1)/TRIF. Which of the candidate molecular functions is a parent term (via 'is_a') of the function described... | molecular_function | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02893","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TICAM2 is associated with multiple molecular functions. One specific function is supported by evidence stating that TICAM-2 acts as a scaffold protei... | |
medium_divergent_branch_02894 | NOD2 is involved in multiple biological processes. One of these processes is supported by evidence showing that co-expression of the NACHT domain of CLAN with Nod1 or Nod2 inhibits the ability of these proteins to generate active IL-1beta. Which biological process is positively regulated by this specific NOD2-associate... | interleukin-1 beta production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02894","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOD2 is involved in multiple biological processes. One of these processes is supported by evidence showing that co-expression of the NACHT domain of ... | |
medium_divergent_branch_02895 | DLGAP2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using the PDZ domains of ProSAP1 and 2 as bait in the yeast two-hybrid system, we isolated several clones of the SAPAP/GKAP (SAP90/PSD-95-associated protein/guanylate kinase-associated protein) family.' Which protein, e... | SH3 and multiple ankyrin repeat domains protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02895","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLGAP2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using the PDZ domains of ProSAP1 and 2 as bait i... | |
medium_divergent_branch_02896 | ADAM10 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating that ADAM10 resides in the postsynaptic densities (PSDs) of excitatory synapses. Which cellular component, linked to ADAM10 by this specific evidence, is itself a part of a... | synapse | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02896","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAM10 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating t... | |
medium_divergent_branch_02897 | Nitroprusside interacts with multiple agents. One of these agents belongs to a class of drugs (gliflozins) that produced little inhibitory effect on agonist-induced aggregation, an effect that was greatly potentiated by approximately 10-fold in the presence of SNP and ILO. Which disease is the selected drug indicated f... | type 2 diabetes mellitus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02897","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Nitroprusside interacts with multiple agents. One of these agents belongs to a class of drugs (gliflozins) that produced little inhibitory effect on ... | |
medium_divergent_branch_02898 | The protein IL17RB is associated with multiple biological processes. One specific association is supported by evidence that IL-17B signaling through IL-17RB directly promotes cancer cell survival, proliferation, and migration. Which biological process, connected to IL17RB via an 'involved in' relationship, is the one d... | cell growth | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02898","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein IL17RB is associated with multiple biological processes. One specific association is supported by evidence that IL-17B signaling through ... | |
medium_divergent_branch_02899 | The protein ABCB6 is associated with multiple cellular components. One specific localization evidence states: 'We show that ABCB6 localizes to the membrane of early melanosomes and lysosomes of the human melanocytic cell line MNT-1.' Based on this evidence, which cellular component is ABCB6 located in, and what is the ... | chitosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02899","source_qa_id":"medium_divergent_branch_04838","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein ABCB6 is associated with multiple cellular components. One specific localization evid... | |
medium_divergent_branch_02900 | RNF213 interacts with multiple genes. One interaction is supported by evidence stating: 'we identified an E2 ubiquitin-conjugating enzyme for RNF213 E3 ubiquitin ligase by yeast two-hybrid screening with a fragment containing the RNF213 RING domain as bait, and the immunocomplex of RNF213 and this enzyme was detected.'... | fetal alcohol syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02900","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF213 interacts with multiple genes. One interaction is supported by evidence stating: 'we identified an E2 ubiquitin-conjugating enzyme for RNF213 ... | |
medium_divergent_branch_02901 | JAG1 is associated with multiple biological processes. One association is supported by evidence that Jagged1 is a DSL family ligand for Notch receptors, which control the proliferation and differentiation of various cell lineages. Which biological process, connected to the process supported by this evidence via an 'is ... | regulation of cellular process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02901","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JAG1 is associated with multiple biological processes. One association is supported by evidence that Jagged1 is a DSL family ligand for Notch recepto... | |
medium_divergent_branch_02902 | MIR98 is associated with multiple biological processes. One association is supported by evidence stating: 'The expression of miR-98 was downregulated in PBMCs of SLE patients, and its expression is negatively associated with IL-6 levels.' Which biological process, connected to the process supported by this evidence, is... | interleukin-6 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02902","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR98 is associated with multiple biological processes. One association is supported by evidence stating: 'The expression of miR-98 was downregulated... | |
medium_divergent_branch_02903 | Type I pneumocytes are structural components of specific lung anatomies. One such connection is supported by evidence describing the distinguishing cell types of lung alveolar tissue, which include pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts), and alve... | alveolus of lung | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02903","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Type I pneumocytes are structural components of specific lung anatomies. One such connection is supported by evidence describing the distinguishing c... | |
medium_divergent_branch_02904 | The gene PTRF (encoding CAVIN1) interacts with multiple proteins. One specific interaction is described by the following evidence: 'For example, we have demonstrated that the interaction with cavin-1, a core component of caveolae essential for their formation, is required for effective inhibition of interleukin (IL)-6 ... | Suppressor of cytokine signaling 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02904","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PTRF (encoding CAVIN1) interacts with multiple proteins. One specific interaction is described by the following evidence: 'For example, we h... | |
medium_divergent_branch_02905 | POC1B interacts with multiple proteins. One of these interaction partners is a luminal centriole protein that binds to A-microtubules and interacts with POC1B, affecting centriole structure and centriole conversion, even in the presence of CEP295 binding to centrioles. Which protein is encoded by the gene corresponding... | Centrosomal protein of 44 kDa | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02905","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"POC1B interacts with multiple proteins. One of these interaction partners is a luminal centriole protein that binds to A-microtubules and interacts w... | |
medium_divergent_branch_02906 | SCUBE1 is associated with multiple biological processes. One association is supported by evidence stating that SCUBE1 and SCUBE2 form a family of secreted proteins expressed in vascular endothelium, potentially playing roles in development, inflammation, and thrombosis. Which biological process, connected to the proces... | wound healing | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02906","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SCUBE1 is associated with multiple biological processes. One association is supported by evidence stating that SCUBE1 and SCUBE2 form a family of sec... | |
medium_divergent_branch_02907 | SLC7A5 is associated with multiple biological processes. One specific association is supported by evidence stating that SLC7A5, a large neutral amino acid transporter localized at the blood-brain barrier (BBB), plays an essential role in maintaining normal levels of brain BCAAs. Which biological process, connected to t... | vascular transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02907","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLC7A5 is associated with multiple biological processes. One specific association is supported by evidence stating that SLC7A5, a large neutral amino... | |
medium_divergent_branch_02908 | The gene GTF3C1 interacts with multiple other genes. One specific interaction partner is supported by evidence stating that the protein hTFIIIC90 interacts with the hTFIIIC220, hTFIIIC110, and hTFIIIC63 subunits of TFIIIC, the hTFIIIB90 subunit of TFIIIB, and the human RPC39 (hRPC39) and hRPC62 subunits of an initiatio... | General transcription factor 3C polypeptide 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02908","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene GTF3C1 interacts with multiple other genes. One specific interaction partner is supported by evidence stating that the protein hTFIIIC90 int... | |
medium_divergent_branch_02909 | UFC1 interacts with multiple genes. One interaction partner is described by the following evidence: 'Activated [the partner] is then transferred to its cognate E2-like enzyme, UFC1, in a similar thioester linkage.' Which disease is associated with this specific interaction partner? | leukodystrophy, hypomyelinating, 14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02909","source_qa_id":"medium_divergent_branch_02110","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"UFC1 interacts with multiple genes. One interaction partner is described by the following evidenc... | |
medium_divergent_branch_02910 | GSK3B is associated with multiple biological processes. One specific association is supported by evidence stating: 'After high-frequency stimulation (HFS), the presynaptic release of glutamate and the expression/clustering of synapsin I, a synaptic vesicle protein playing an important role in neurotransmitter release, ... | presynapse | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02910","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GSK3B is associated with multiple biological processes. One specific association is supported by evidence stating: 'After high-frequency stimulation ... | |
medium_divergent_branch_02911 | CRKL interacts with multiple genes. One of these interacting partners forms a complex with a tyrosine kinase gene, as demonstrated by coimmunoprecipitation, and is capable of direct interaction in a yeast two-hybrid assay. Which disease is connected to this specific interacting partner through genomic alterations? | T-cell childhood acute lymphocytic leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02911","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CRKL interacts with multiple genes. One of these interacting partners forms a complex with a tyrosine kinase gene, as demonstrated by coimmunoprecipi... | |
medium_divergent_branch_02912 | KRT14 interacts with multiple genes. One interaction is supported by evidence stating: 'Among interactions between trichoplein and various IF proteins that we tested using two-hybrid methods, trichoplein interacted significantly with K16 and K18, and to some extent with K5, K6a, K8 and K14.' Which disease is associated... | breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02912","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KRT14 interacts with multiple genes. One interaction is supported by evidence stating: 'Among interactions between trichoplein and various IF protein... | |
medium_divergent_branch_02914 | CPEB2 interacts with multiple proteins. One specific interaction involves an elongation factor that reduces GTP hydrolysis triggered by the factor/ribosome complex in vitro and slows peptide elongation of CPEB2-bound RNA in vivo. Which protein is encoded by the gene corresponding to this interacting elongation factor? | Elongation factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02914","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CPEB2 interacts with multiple proteins. One specific interaction involves an elongation factor that reduces GTP hydrolysis triggered by the factor/ri... | |
medium_divergent_branch_02915 | FBXL16 interacts with multiple proteins. One specific interaction is described by the following evidence: 'In our experiments, FBXL16 binds PP2A to promote the dephosphorylation of Thr286 site of cyclin D1 via AKT1/GSK3'. Which protein, encoded by the gene corresponding to the regulatory subunit of PP2A involved in thi... | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02915","source_qa_id":"medium_divergent_branch_03763","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FBXL16 interacts with multiple proteins. One specific interaction is described by the following e... | |
medium_divergent_branch_02916 | The gene CENPW is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 17.14 TPM, a z-score of 1.57, and a fold enrichment of 2.89. Which cell type corresponds to this specific expression profile, and what is its direct parent category in the cell type hi... | dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02916","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CENPW is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 17.14 TPM, a ... | |
medium_divergent_branch_02917 | Decorin (DCN) interacts with multiple TGF-beta family members. Experimental evidence indicates that proteoglycan core proteins, when expressed as fusion proteins, specifically bound TGF-beta 1. Which protein is encoded by the gene corresponding to this specific binding partner? | Transforming growth factor beta-1 proprotein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02917","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Decorin (DCN) interacts with multiple TGF-beta family members. Experimental evidence indicates that proteoglycan core proteins, when expressed as fus... | |
medium_divergent_branch_02918 | NFATC1 interacts with multiple genes. One of these interaction partners is identified in a study reporting unknown interaction partners of NFATc1 and NFATc2 in T cells, specifically listing the gene encoding the regulatory-associated protein of mTOR, CHEK1, CREB1, RUNX1, SATB1, Ikaros, and Helios. Which disease is conn... | kwashiorkor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02918","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFATC1 interacts with multiple genes. One of these interaction partners is identified in a study reporting unknown interaction partners of NFATc1 and... | |
medium_divergent_branch_02920 | GTF2I interacts with multiple genes. One specific interaction involves a tripartite motif protein that was found to be constitutively associated with the HIV-1 LTR alongside TFII-I. Which disease is connected to this interacting gene through genomic alterations? | thyroid gland papillary carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02920","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GTF2I interacts with multiple genes. One specific interaction involves a tripartite motif protein that was found to be constitutively associated with... | |
medium_divergent_branch_02921 | IGHMBP2 is associated with multiple molecular functions. One line of evidence states: 'Our data reveal that IGHMBP2 is an ATP-dependent 5' --> 3' helicase, which unwinds RNA and DNA duplices in vitro.' Which molecular function, connected to the function described by this evidence via an 'is_a' relationship, is the corr... | nucleic acid binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02921","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGHMBP2 is associated with multiple molecular functions. One line of evidence states: 'Our data reveal that IGHMBP2 is an ATP-dependent 5' --> 3' hel... | |
medium_divergent_branch_02922 | RNF31 interacts with multiple proteins. One interaction is supported by evidence that TNFα induces the recruitment of a serine/threonine-protein kinase to the TNF receptor signaling complex (TNF-RSC) and its subsequent interaction with HOIP, the catalytic component of the linear ubiquitin assembly complex (LUBAC). Whic... | Serine/threonine-protein kinase 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02922","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF31 interacts with multiple proteins. One interaction is supported by evidence that TNFα induces the recruitment of a serine/threonine-protein kina... | |
medium_divergent_branch_02923 | MEF2C interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The interaction was confirmed by a glutathione S-transferase-pull down assay and a co-immunoprecipitation study indicating that endogenous [protein encoded by MAPK7] and MEF2 interact with each other in vivo.' Which prot... | Mitogen-activated protein kinase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02923","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MEF2C interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The interaction was confirmed by a glutathione S-... | |
medium_divergent_branch_02924 | The gene IL1R1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'IL-1 treatment of cells induces the formation of a complex containing both IL-1RI and a partner protein.' Which protein is encoded by the gene corresponding to the partner mentioned in this evidence? | Interleukin-1 receptor accessory protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02924","source_qa_id":"medium_divergent_branch_07431","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene IL1R1 interacts with multiple partners. One specific interaction is supported by evidenc... | |
medium_divergent_branch_02925 | EIF1 is associated with multiple biological processes. One association is supported by evidence stating that interactions among translation initiation factors, including EIF1 and eIF5, govern start codon selection. Which broader biological process is the parent of this specific process in the ontology hierarchy? | regulation of translation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02925","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF1 is associated with multiple biological processes. One association is supported by evidence stating that interactions among translation initiatio... | |
medium_divergent_branch_02927 | CDK5 interacts with multiple proteins. One interaction is supported by evidence stating that 'Both hAATYKs and a specific protein bound to and were phosphorylated by Cdk5/p35.' Which protein, connected to CDK5 via this specific interaction evidence, is encoded by the gene in question? | Serine/threonine-protein kinase LMTK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02927","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK5 interacts with multiple proteins. One interaction is supported by evidence stating that 'Both hAATYKs and a specific protein bound to and were p... | |
medium_divergent_branch_02928 | The gene WAS interacts with multiple partners. One specific interaction partner is characterized by the following evidence: 'Importantly, ectopically overexpressed [this partner] binds tightly with N-WASP, thus inactivating the fibronectin/integrin/FAK pathway, which in turn leads to the suppression of F-actin dynamics... | glioma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02928","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene WAS interacts with multiple partners. One specific interaction partner is characterized by the following evidence: 'Importantly, ectopically... | |
medium_divergent_branch_02930 | The gene F2R interacts with multiple partners. One specific interaction is characterized by the following mechanism: in gastric epithelial cells (GECs), the interacting protein directly binds to PAR1 and negatively regulates it via lysosomal degradation. This process abrogates the suppression of CXCL2 production and su... | Arrestin domain-containing protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02930","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene F2R interacts with multiple partners. One specific interaction is characterized by the following mechanism: in gastric epithelial cells (GEC... | |
medium_divergent_branch_02931 | HCFC1 interacts with multiple genes. One of these interaction partners is described in proteomic analyses as having HCF-1 and O-GlcNAc transferase (OGT) as major cellular partners. Which biological process is this specific interaction partner involved in? | positive regulation of transcription by RNA polymerase II | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02931","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HCFC1 interacts with multiple genes. One of these interaction partners is described in proteomic analyses as having HCF-1 and O-GlcNAc transferase (O... | |
medium_divergent_branch_02932 | EMP2 is associated with multiple biological processes. One specific association is supported by evidence stating: 'We showed that EMP2 exclusively localized to glomeruli in the kidney.' Which biological process is regulated by the process linked to EMP2 via this specific evidence? | glomerular filtration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02932","source_qa_id":"medium_divergent_branch_02906","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"EMP2 is associated with multiple biological processes. One specific association is supported by e... | |
medium_divergent_branch_02933 | COPB1 interacts with multiple genes. One of these interaction partners was identified in a study that reported, for the first time, members of the coatomer I (COPI) complex as interaction partners of hSAC1. Which biological process is the gene identified in this specific study involved in? | phosphatidylinositol dephosphorylation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02933","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COPB1 interacts with multiple genes. One of these interaction partners was identified in a study that reported, for the first time, members of the co... | |
medium_divergent_branch_02934 | PIK3R1 interacts with multiple genes. One interaction partner is described as a member of the ADAM family of transmembrane metalloprotease-disintegrins, implicated in the differentiation of skeletal myoblasts, with its cytoplasmic tail shown to interact with the Src homology 3 domain of the p85alpha regulatory subunit ... | plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02934","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIK3R1 interacts with multiple genes. One interaction partner is described as a member of the ADAM family of transmembrane metalloprotease-disintegri... | |
medium_divergent_branch_02935 | The gene QPRT interacts with multiple other genes. One of these interacting partners has been experimentally validated in human neuroblastoma cells or brain tissues, specifically in studies reporting interactions with a subset of candidates including EEF1A1, FLNA, ITPRIP, CYP11A1, MT-CO2, GPR175, and ACOT2. Which prote... | Neuroligin-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02935","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene QPRT interacts with multiple other genes. One of these interacting partners has been experimentally validated in human neuroblastoma cells o... | |
medium_divergent_branch_02936 | AGAP1 interacts with multiple proteins. One of these interactions is supported by evidence stating that coimmunoprecipitation confirmed AGAP1 and AGAP2 can bind to the target protein. Which protein is encoded by the gene corresponding to this target protein? | Transforming protein RhoA | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02936","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AGAP1 interacts with multiple proteins. One of these interactions is supported by evidence stating that coimmunoprecipitation confirmed AGAP1 and AGA... | |
medium_divergent_branch_02937 | FTH1 interacts with multiple genes. One specific interaction is characterized by the following evidence: 'Through analysis of the [partner]-FTH1 interaction, we demonstrate that direct association via a key surface arginine in FTH1 and a C-terminal element in the [partner] is required for delivery of ferritin to the ly... | androgenetic alopecia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02937","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FTH1 interacts with multiple genes. One specific interaction is characterized by the following evidence: 'Through analysis of the [partner]-FTH1 inte... | |
medium_divergent_branch_02938 | ATN1 interacts with multiple genes. One interaction is supported by evidence stating: 'Using the yeast two-hybrid system, we identified a component of nuclear receptor corepressor complexes, as an atrophin-1-interacting protein.' Which cellular component is the gene identified in this specific evidence located in? | nuclear matrix | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02938","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATN1 interacts with multiple genes. One interaction is supported by evidence stating: 'Using the yeast two-hybrid system, we identified a component o... | |
medium_divergent_branch_02939 | MIS18A interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that the N-terminal region of this protein spanning amino acid residues 20-130 directly interacts with Mis18α/β to form the Mis18 complex.' Which protein, connected to MIS18A via a binding interaction, is described by th... | Mis18-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02939","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIS18A interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that the N-terminal region of this protein spanni... | |
medium_divergent_branch_02941 | SGK1 interacts with multiple genes. One of these interacting partners is characterized by evidence stating: 'The N termini of the WNKs also have the capacity to interact with SGK1.' Which disease is associated with this interacting partner via a biomarker relationship? | pseudohypoaldosteronism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02941","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SGK1 interacts with multiple genes. One of these interacting partners is characterized by evidence stating: 'The N termini of the WNKs also have the ... | |
medium_divergent_branch_02942 | PTCH1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, it was mechanistically determined that [Protein X], essential for mammalian autophagy, physically interacts with the CTD of PTCH1 and connects it to the ULK complex, which stimulates the autophagy machinery in resp... | Autophagy-related protein 101 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02942","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTCH1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, it was mechanistically determined that [Pro... | |
medium_divergent_branch_02943 | MAD2L2 is reported to interact with multiple proteins. One specific interaction is supported by evidence stating: 'In addition, we have identified an interaction between hREV7 and hMAD2 but not hMAD1.' Which protein, linked to MAD2L2 by this interaction, is encoded by the gene corresponding to the interacting partner m... | DNA polymerase zeta catalytic subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02943","source_qa_id":"medium_divergent_branch_05318","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MAD2L2 is reported to interact with multiple proteins. One specific interaction is supported by e... | |
medium_divergent_branch_02944 | The pre-T cell receptor complex is associated with multiple thymocyte stages via plasma membrane localization. One specific stage is characterized by a phenotype that is CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive. Which cell type does this specific thymocyte stage develop from? | DN3 thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02944","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The pre-T cell receptor complex is associated with multiple thymocyte stages via plasma membrane localization. One specific stage is characterized by... | |
medium_divergent_branch_02945 | MDM2 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'We have established that full-length [protein] associates with Mdm2 in cells where it can deubiquitinate Mdm2 while demonstrating no deubiquitinating activity towards p53.' Which protein, encoded by the gene con... | Ubiquitin carboxyl-terminal hydrolase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02945","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MDM2 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'We have established that full-length [pr... | |
medium_divergent_branch_02946 | PTPN22 is associated with multiple biological processes. One association is supported by evidence stating: 'The current study shows that the T variant of the rs2476601 SNP could alter NK vs T-cell balance in vitro and suggests that the PTPN22 gene might have an important immune regulatory role in NK cell function which... | innate immune response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02946","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTPN22 is associated with multiple biological processes. One association is supported by evidence stating: 'The current study shows that the T varian... | |
medium_divergent_branch_02947 | UBR4 interacts with multiple proteins. One of these interaction partners is characterized by evidence showing that its C-terminus binds directly to RAD6, while its N-terminal domains interact with UBR4 and other intracellular vesicle- and mitochondria-associated proteins. Which protein is this interaction partner? | E3 ubiquitin-protein ligase KCMF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02947","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBR4 interacts with multiple proteins. One of these interaction partners is characterized by evidence showing that its C-terminus binds directly to R... |
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