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medium_divergent_branch_02948 | BMP7 interacts with multiple proteins. One interaction is supported by evidence stating that OP-1 binds efficiently to ALK-2 and ALK-6, and less efficiently to ALK-3. Which protein, connected to BMP7 via this specific binding evidence, is encoded by the gene in question? | Bone morphogenetic protein receptor type-1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02948","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMP7 interacts with multiple proteins. One interaction is supported by evidence stating that OP-1 binds efficiently to ALK-2 and ALK-6, and less effi... | |
medium_divergent_branch_02949 | GZMK interacts with multiple proteins. One interaction is supported by evidence stating that the interacting protein is hydrolyzed by GZMK in its recombinant and native forms or in intact cells. Which protein is encoded by the gene corresponding to this interacting partner? | Protein SET | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02949","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GZMK interacts with multiple proteins. One interaction is supported by evidence stating that the interacting protein is hydrolyzed by GZMK in its rec... | |
medium_divergent_branch_02950 | The gene NINJ1 is associated with multiple biological processes. One specific association is supported by evidence describing the entity as a secreted atheroprotective protein that regulates macrophage inflammation and monocyte recruitment in atherosclerosis. Which biological process is a parent term (via an 'is a' rel... | defense response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02950","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NINJ1 is associated with multiple biological processes. One specific association is supported by evidence describing the entity as a secrete... | |
medium_divergent_branch_02951 | The semicircular duct is anatomically part of a larger structure. Evidence for this connection describes the semicircular duct as one of three loop-shaped membranous inner tubular parts that are about one-fourth the diameter of the corresponding outer bony canals, communicate at each end with the utricle, and possess a... | tube | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02951","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The semicircular duct is anatomically part of a larger structure. Evidence for this connection describes the semicircular duct as one of three loop-s... | |
medium_divergent_branch_02952 | SAMHD1 interacts with multiple proteins. One of these interaction partners is an E3 ubiquitin ligase that specifically interacts with and degrades SAMHD1 through the proteasomal pathway. Which disease is associated with this specific E3 ubiquitin ligase? | vitiligo | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02952","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SAMHD1 interacts with multiple proteins. One of these interaction partners is an E3 ubiquitin ligase that specifically interacts with and degrades SA... | |
medium_divergent_branch_02954 | TNPO1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'We show that the interaction with two of these proteins, namely XPO1 exportin and TNPO1 importin, occurs via the C-terminal region of CA IX and increases with protein phosphorylation.' Which disease is connected to the gen... | urinary bladder carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02954","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNPO1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'We show that the interaction with two of these prot... | |
medium_divergent_branch_02955 | BRF1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that a RING domain-containing ubiquitin E3 ligase, physically interacts with BRF1.' Which cell type is this interaction partner enriched in? | basophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02955","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRF1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that a RING domain-containing ubiquitin E3 ligas... | |
medium_divergent_branch_02956 | HNRNPF interacts with multiple genes. One specific interaction is characterized by evidence showing that ECD competitively binds to hnRNP F via its N-terminal STG1 domain (amino acids 13-383). This binding prevents hnRNP F from interacting with a specific partner, thereby inhibiting the partner-mediated ubiquitination ... | MAP3K14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02956","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HNRNPF interacts with multiple genes. One specific interaction is characterized by evidence showing that ECD competitively binds to hnRNP F via its N... | |
medium_divergent_branch_02957 | The gene WT1 is reported to interact with multiple partners. One specific interaction is supported by evidence stating: 'Both in vitro and in vivo assays have shown that the interaction between this partner and WT1 is specific and occurs endogenously in cells.' Which gene is this interaction partner? | WTAP | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02957","source_qa_id":"medium_divergent_branch_06299","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene WT1 is reported to interact with multiple partners. One specific interaction is supporte... | |
medium_divergent_branch_02958 | CDK5 interacts with multiple genes. One of these interaction partners is a ubiquitin ligase that is directly bound and phosphorylated by EGFR-activated CDK5 at serine 308. This phosphorylation event recruits PIN1 for cis-trans isomerization, subsequently enabling the ligase to bind importin α5 and undergo nuclear trans... | clear cell renal carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02958","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK5 interacts with multiple genes. One of these interaction partners is a ubiquitin ligase that is directly bound and phosphorylated by EGFR-activat... | |
medium_divergent_branch_02959 | The gene TENM4 is associated with multiple biological processes. One specific association is supported by evidence stating that 'processes regulating myelination in the central nervous system and axon guidance might be significant contributors to the genetic burden of this disorder.' Identify the biological process tha... | myelin assembly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02959","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TENM4 is associated with multiple biological processes. One specific association is supported by evidence stating that 'processes regulating... | |
medium_divergent_branch_02961 | Renal water absorption is associated with multiple anatomical structures. One of these structures is described as the inner portion of the kidney consisting of the renal pyramids. What is the broader anatomical category (is_a) of this specific structure? | medulla of organ | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02961","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Renal water absorption is associated with multiple anatomical structures. One of these structures is described as the inner portion of the kidney con... | |
medium_divergent_branch_02962 | NCKIPSD interacts with multiple genes. One of these interaction partners is described in evidence stating: 'We identified a new mDia-interacting protein which is expressed ubiquitously.' Which molecular function is enabled by this specific interaction partner? | cadherin binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02962","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCKIPSD interacts with multiple genes. One of these interaction partners is described in evidence stating: 'We identified a new mDia-interacting prot... | |
medium_divergent_branch_02963 | DAB1 interacts with multiple genes. One interaction is supported by evidence stating: 'Using yeast 2-hybrid and protein coprecipitation approaches in vitro, we show that the neuronal adaptor proteins FE65 and mammalian Disabled bind to the cytoplasmic tails of LRP, LDL receptor, and APP, where they can potentially serv... | sitosterolemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02963","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DAB1 interacts with multiple genes. One interaction is supported by evidence stating: 'Using yeast 2-hybrid and protein coprecipitation approaches in... | |
medium_divergent_branch_02964 | NHERF2 is known to bind to multiple gene products. One specific interaction is supported by evidence stating: 'NHERFs were shown to interact directly with a receptor tyrosine kinase, and we demonstrate the assembly of a ternary complex between PTEN, NHERFs and this receptor.' Based on this description, which protein is... | Platelet-derived growth factor receptor beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02964","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NHERF2 is known to bind to multiple gene products. One specific interaction is supported by evidence stating: 'NHERFs were shown to interact directly... | |
medium_divergent_branch_02965 | CHTF18 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this report we demonstrate that in 293T cells, Flag-tagged Ctf18 forms a seven-subunit cohesion-RFC complex comprised of Ctf18, Dcc1, Ctf8, RFCp40, RFCp38, RFCp37, and RFCp36 (Ctf18-RFC).' Which protein, among those interacti... | Replication factor C subunit 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02965","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHTF18 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this report we demonstrate that in 293T cells, Flag-ta... | |
medium_divergent_branch_02966 | SIAH1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Molecularly, a yeast two-hybrid experiment indicated that Cln Three Requiring 9 was a potential interacting protein of SIAH1, which was further verified by co-immunoprecipitation assays.' What is the name of the protein encoded b... | RNA polymerase-associated protein CTR9 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02966","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIAH1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Molecularly, a yeast two-hybrid experiment indicated that ... | |
medium_divergent_branch_02967 | CNNM3 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that PRL-2 regulates intracellular magnesium levels by forming a functional heterodimer with the magnesium transporter CNNM3.' Which gene, connected to CNNM3 via an interaction, is the subject of this specific evidence,... | TUBA1B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02967","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CNNM3 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that PRL-2 regulates intracellular magnesium lev... | |
medium_divergent_branch_02968 | The biological process 'negative regulation of glycine import across plasma membrane' is defined as any process that stops, prevents, or reduces the frequency, rate, or extent of glycine import into a cell. This process is a subtype of a broader regulatory process. Which of the following broader processes is it a subty... | amino acid transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02968","source_qa_id":"medium_divergent_branch_07400","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'negative regulation of glycine import across plasma membrane' is defined ... | |
medium_divergent_branch_02970 | H2AX interacts with multiple proteins. One interaction partner is implicated in a pathway where ZNF668 knockdown, in response to ionizing radiation (IR), reduces the interaction between the protein encoded by KAT5 and this partner, thereby impairing IR-induced hyperacetylation of H2AX. Which protein, encoded by the gen... | Histone acetyltransferase KAT5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02970","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"H2AX interacts with multiple proteins. One interaction partner is implicated in a pathway where ZNF668 knockdown, in response to ionizing radiation (... | |
medium_divergent_branch_02971 | PHF8 interacts with multiple genes. One of these interacting partners is an XMR protein that binds to a subset of PHF8 target genes, including the XMR gene JARID1C. Which disease is associated with this specific interacting partner? | intellectual disability, X-linked 97 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02971","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PHF8 interacts with multiple genes. One of these interacting partners is an XMR protein that binds to a subset of PHF8 target genes, including the XM... | |
medium_divergent_branch_02972 | FADD is known to bind to multiple proteins. One specific interaction partner is described in the literature as directly interacting with TRAF2 and FADD, where these partners act as signal transducers that activate NF-kappa B and induce apoptosis, respectively. Based on this description, which gene is connected to FADD ... | TNFRSF25 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02972","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FADD is known to bind to multiple proteins. One specific interaction partner is described in the literature as directly interacting with TRAF2 and FA... | |
medium_divergent_branch_02973 | PIK3R1 interacts with multiple genes. One interaction is supported by evidence stating: 'The interaction of TbetaRI with p85 was induced by treatment with TGFbeta.' Which protein is encoded by the gene that interacts with PIK3R1 in this specific context? | TGF-beta receptor type-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02973","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIK3R1 interacts with multiple genes. One interaction is supported by evidence stating: 'The interaction of TbetaRI with p85 was induced by treatment... | |
medium_divergent_branch_02974 | PGRMC1 interacts with multiple proteins. One specific interaction is characterized by the following evidence: In cells cotransfected with CPR and the interacting partner, strong binding of CPR to the partner was observed; however, in the presence of CYP2C2, the interaction between the partner and CPR was significantly ... | NADPH--cytochrome P450 reductase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02974","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PGRMC1 interacts with multiple proteins. One specific interaction is characterized by the following evidence: In cells cotransfected with CPR and the... | |
medium_divergent_branch_02975 | The sphenoid cartilage element is classified as a type of two different anatomical structures. One of these parent structures is described in the evidence as a sphenoid endochondral element composed primarily of cartilage tissue. Which anatomical structure is the sphenoid cartilage element a subtype of, based on this d... | cranial cartilage | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02975","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The sphenoid cartilage element is classified as a type of two different anatomical structures. One of these parent structures is described in the evi... | |
medium_divergent_branch_02976 | MARCH5 interacts with multiple proteins. Evidence for one specific interaction indicates that MARCH5 binds the target protein, and that MARCH5-dependent ubiquitylation of this target is significantly elevated under mitochondrial stress conditions, accompanied by an increase in the acetylation of the target. Which prote... | Mitofusin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02976","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MARCH5 interacts with multiple proteins. Evidence for one specific interaction indicates that MARCH5 binds the target protein, and that MARCH5-depend... | |
medium_divergent_branch_02977 | POLD3 interacts with multiple genes. One interaction partner is described by the following evidence: 'Interestingly, a specific protein binds to replicative DNA polymerase POLD3 and PDIP1 under normal conditions but preferentially associates with TLS polymerase η (POLH) upon UV damage.' Which disease is associated with... | progeroid features-hepatocellular carcinoma predisposition syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02977","source_qa_id":"medium_divergent_branch_02841","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"POLD3 interacts with multiple genes. One interaction partner is described by the following eviden... | |
medium_divergent_branch_02978 | An astrocyte-restricted precursor is a type of cell in the central nervous system that differentiates exclusively into astrocytes. This cell type expresses CD44 and S100 calcium-binding protein B. Which broader cell category is the astrocyte-restricted precursor a subtype of? | neuron associated cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02978","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"An astrocyte-restricted precursor is a type of cell in the central nervous system that differentiates exclusively into astrocytes. This cell type exp... | |
medium_divergent_branch_02979 | CUL2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Recently, the VHL-Elongin BC complex was found to interact with a module composed of Cullin family member Cul2 and RING-H2 finger protein Rbx1 to reconstitute a novel E3 ubiquitin ligase that activates ubiquitylation by the E2 ubi... | Elongin-C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02979","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CUL2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Recently, the VHL-Elongin BC complex was found to interact ... | |
medium_divergent_branch_02980 | ICAM3 is reported to interact with multiple proteins. One specific interaction is supported by evidence stating: 'Protein-protein binding assays demonstrated a phosphatidylinositol 4,5-bisphosphate-induced association between ICAM-3 and the amino-terminal domain of ERM proteins.' Which protein is encoded by the gene co... | Ezrin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02980","source_qa_id":"medium_divergent_branch_04069","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ICAM3 is reported to interact with multiple proteins. One specific interaction is supported by ev... | |
medium_divergent_branch_02981 | The gene WT1 is associated with multiple biological processes. One specific association is supported by evidence that WT1 isoforms strongly activate the promoter of SRY (the sex-determining region of the Y chromosome). Identify the biological process linked to this specific WT1 function that is a parent term (is_a) of ... | developmental process involved in reproduction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02981","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene WT1 is associated with multiple biological processes. One specific association is supported by evidence that WT1 isoforms strongly activate ... | |
medium_divergent_branch_02982 | MAP1LC3C interacts with multiple proteins. One of these interaction partners is described in evidence stating: 'Strikingly, in addition to ULK1 and ULK2, this protein and FIP200 interacted with human ATG8 proteins, all with strong preference for the GABARAP subfamily.' Which protein, connected to MAP1LC3C via an intera... | Autophagy-related protein 13 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02982","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP1LC3C interacts with multiple proteins. One of these interaction partners is described in evidence stating: 'Strikingly, in addition to ULK1 and U... | |
medium_divergent_branch_02983 | PHIP interacts with multiple genes. One specific interaction involves a partner that is recognized by RepID (DCAF14/PHIP), a member of the CRL4 complex. This partner is a kinetochore-localizing protein that serves as a CRL4 substrate, and RepID recruits the CRL4 complex to chromatin or chromosomes using its WD40 domain... | aneuploidy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02983","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PHIP interacts with multiple genes. One specific interaction involves a partner that is recognized by RepID (DCAF14/PHIP), a member of the CRL4 compl... | |
medium_divergent_branch_02984 | POGZ interacts with multiple genes. One of these interaction partners is reported to be found in a complex with the heterochromatin-binding chromobox homologue 1 (CBX1) and Pogo transposable element with ZNF domain (POGZ). Which gene is this interaction partner? | MACROH2A1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02984","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"POGZ interacts with multiple genes. One of these interaction partners is reported to be found in a complex with the heterochromatin-binding chromobox... | |
medium_divergent_branch_02985 | West Nile virus downregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of -1.345 and an adjusted p-value of 0.01125. Which cell type is the gene associated with this specific statistical evidence enriched in? | peripheral blood mononuclear cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02985","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"West Nile virus downregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of -1.345 and an adjusted p-val... | |
medium_divergent_branch_02986 | BCL2L13 interacts with multiple proteins. One of these interaction partners is described as binding to proapoptotic ceramide synthases 2 and 6 via a unique C-terminal 250-amino acid sequence located between its Bcl-2 homology and membrane anchor domains, thereby blocking homo- and heteromeric complex formation and acti... | Ceramide synthase 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02986","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL2L13 interacts with multiple proteins. One of these interaction partners is described as binding to proapoptotic ceramide synthases 2 and 6 via a ... | |
medium_divergent_branch_02987 | The gene AP3S2 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here, we report an interdomain interaction involving the ear domain of the delta subunit and the sigma3 subunit of AP-3.' Which protein is encoded by the gene that interacts with AP3S2 in this specific context? | AP-3 complex subunit delta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02987","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AP3S2 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here, we report an interdomain interacti... | |
medium_divergent_branch_02988 | The gene AIF1 is associated with multiple biological processes. One specific association is supported by evidence showing that MOLT-4 cells overexpressing AIF-1 migrated 95% more rapidly than empty vector controls. Identify the biological process that is positively regulated by the process linked to AIF1 via this speci... | T cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02988","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AIF1 is associated with multiple biological processes. One specific association is supported by evidence showing that MOLT-4 cells overexpre... | |
medium_divergent_branch_02989 | USP20 interacts with multiple proteins. One of these interaction partners is phosphorylated by ATR, an event that causes the dissociation of an E3 ubiquitin ligase from USP20 and leads to the stabilization of USP20. Which protein, encoded by the gene interacting with USP20, corresponds to this E3 ubiquitin ligase? | E3 ubiquitin-protein ligase HERC2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02989","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP20 interacts with multiple proteins. One of these interaction partners is phosphorylated by ATR, an event that causes the dissociation of an E3 ub... | |
medium_divergent_branch_02990 | RNF115 interacts with multiple proteins. One of these interaction partners is constitutively bound by RNF115 in uninfected cells, where RNF115 induces its K48-linked ubiquitination and subsequent proteasomal degradation to maintain homeostasis. Which protein is encoded by the gene corresponding to this specific interac... | Mitochondrial antiviral-signaling protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02990","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF115 interacts with multiple proteins. One of these interaction partners is constitutively bound by RNF115 in uninfected cells, where RNF115 induce... | |
medium_divergent_branch_02991 | The gene SAFB interacts with multiple partners. One specific interaction is characterized by direct binding through a C-terminal domain, which results in additive repression activity. Which protein is encoded by the gene involved in this specific interaction? | Scaffold attachment factor B2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02991","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SAFB interacts with multiple partners. One specific interaction is characterized by direct binding through a C-terminal domain, which result... | |
medium_divergent_branch_02992 | Primate erythroparvovirus 1 upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.865 and an adjusted p-value of 0.0488. Which disease has a causal relation with that selected gene? | disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02992","source_qa_id":"medium_divergent_branch_04472","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Primate erythroparvovirus 1 upregulates several genes. In the recorded experiment, one branch ... | |
medium_divergent_branch_02993 | IL13 interacts with multiple proteins. One interaction partner is described in a context where its function remains unclear despite binding IL-13 with high affinity. Which protein is encoded by the gene corresponding to this specific interaction partner? | Interleukin-13 receptor subunit alpha-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02993","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL13 interacts with multiple proteins. One interaction partner is described in a context where its function remains unclear despite binding IL-13 wit... | |
medium_divergent_branch_02994 | AQP1 is associated with multiple biological processes. One association is supported by evidence stating: 'our data suggest that AQP1 is involved in hypoxia-inducible angiogenesis in retinal vascular endothelial cells.' Which cell type is linked to this specific biological process via the 'enabled by cell' relationship? | circulating fibrocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02994","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AQP1 is associated with multiple biological processes. One association is supported by evidence stating: 'our data suggest that AQP1 is involved in h... | |
medium_divergent_branch_02995 | RAB10 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 403.33 TPM, a z-score of 2.26, and a fold enrichment of 2.96. Which cell type does this specific RAB10-enriched cell develop from? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02995","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB10 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 403.33 TPM, a z-score of 2.26, and a fold enrichment ... | |
medium_divergent_branch_02996 | LUZP1 is associated with multiple cellular components via 'located in' relationships. One piece of evidence states: 'We further show that LUZP1 localizes to both actin filaments and the centrosome/basal body.' Based on this evidence, which specific cellular component is linked to LUZP1, and what is the parent term in t... | microtubule organizing center | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02996","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LUZP1 is associated with multiple cellular components via 'located in' relationships. One piece of evidence states: 'We further show that LUZP1 local... | |
medium_divergent_branch_02997 | The SBDS protein interacts with multiple partners. One specific interaction was confirmed using GST-pull down assays with recombinant proteins and co-immunoprecipitation in HEK293T cells overexpressing the interacting partner. Which protein, encoded by the gene connected to SBDS via this specific interaction, is the su... | E3 ubiquitin-protein ligase RING2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02997","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The SBDS protein interacts with multiple partners. One specific interaction was confirmed using GST-pull down assays with recombinant proteins and co... | |
medium_divergent_branch_02998 | ZMYND11 interacts with multiple proteins. One of these interaction partners is described in experimental evidence as a negative regulator of NF-kappaB activation, with which a compound named BS69 was found to directly interact. Which protein, encoded by the gene connected to ZMYND11 via this specific interaction, is th... | TNF receptor-associated factor 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_02998","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZMYND11 interacts with multiple proteins. One of these interaction partners is described in experimental evidence as a negative regulator of NF-kappa... | |
medium_divergent_branch_03000 | Apoptotic cell clearance is enabled by more than one cell type. One of these cells is described as a splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen, participating in the phagocytosis of apoptotic B cells, with Mertk as a positive marker. Which anatomical structure... | spleen lymphoid follicle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03000","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Apoptotic cell clearance is enabled by more than one cell type. One of these cells is described as a splenic white pulp macrophage found in and aroun... | |
medium_divergent_branch_03001 | CSK interacts with multiple genes. One of these interactions is supported by evidence stating: 'We have found that a major interaction also exists between beta-arrestin1 and the catalytic or kinase domain (SH1) of c-SRC.' Which disease is associated with the gene identified by this evidence via a biomarker relationship... | renal fibrosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03001","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CSK interacts with multiple genes. One of these interactions is supported by evidence stating: 'We have found that a major interaction also exists be... | |
medium_divergent_branch_03003 | The insulin receptor (INSR) interacts with multiple proteins. One interaction is supported by evidence stating: 'The regulatory subunit N + C (amino plus carboxyl) SH2 domains were demonstrated to associate with the autophosphorylated beta-subunit.' Which protein, encoded by the gene involved in this specific interacti... | Phosphatidylinositol 3-kinase regulatory subunit alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03003","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The insulin receptor (INSR) interacts with multiple proteins. One interaction is supported by evidence stating: 'The regulatory subunit N + C (amino ... | |
medium_divergent_branch_03005 | ARRB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our study demonstrates that beta-Arrestins physically associate with C-terminal domain of [interacting partner].' Which protein product is encoded by the gene corresponding to this interacting partner? | Mitogen-activated protein kinase kinase kinase 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03005","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARRB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our study demonstrates that beta-Arrestins physically asso... | |
medium_divergent_branch_03006 | The macrophage dendritic cell progenitor is a subtype of two distinct cell categories. One of these categories is defined by its capacity to give rise to plasmacytoid and myeloid dendritic cells, as well as to monocytes and macrophages. Which cell type does this specific progenitor develop from? | hematopoietic multipotent progenitor cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03006","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The macrophage dendritic cell progenitor is a subtype of two distinct cell categories. One of these categories is defined by its capacity to give ris... | |
medium_divergent_branch_03007 | ANGPT1 is associated with multiple biological processes. One specific association is supported by evidence showing that Ang1/Tie-2 signaling, via the ERK1/2 pathway, decreases muscle progenitor cell (MPC) proliferation and differentiation, increases the number of cells in G0, upregulates regenerative cell-associated ma... | skeletal muscle satellite cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03007","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANGPT1 is associated with multiple biological processes. One specific association is supported by evidence showing that Ang1/Tie-2 signaling, via the... | |
medium_divergent_branch_03008 | FBXO32 interacts with multiple genes. One of these interaction partners was identified as an FBXO32-interacting protein through yeast two-hybrid screening and microarray analysis, alongside KHDRBS3. Which cellular component is this specific interaction partner located in? | cytoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03008","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO32 interacts with multiple genes. One of these interaction partners was identified as an FBXO32-interacting protein through yeast two-hybrid scre... | |
medium_divergent_branch_03009 | The gene CHUK interacts with multiple partners. One specific interaction partner is supported by evidence stating: 'We demonstrate that endogenous this protein interacted with IKKα and IKKβ in THP-1 cells and recombinant this protein bound to purified IKKα or IKKβ directly in vitro.' Which disease is associated with th... | chilblain lupus 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03009","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CHUK interacts with multiple partners. One specific interaction partner is supported by evidence stating: 'We demonstrate that endogenous th... | |
medium_divergent_branch_03010 | PARP1 is involved in multiple biological processes. One specific process is supported by evidence stating that mitochondrial PARP1, in contrast to nuclear PARP1, exerts a negative effect on several mitochondrial-specific transactions, including the repair of mitochondrial DNA. Which broader biological process is this s... | DNA metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03010","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PARP1 is involved in multiple biological processes. One specific process is supported by evidence stating that mitochondrial PARP1, in contrast to nu... | |
medium_divergent_branch_03011 | ADAM8 is associated with multiple biological processes via the 'involved in' relationship. One specific piece of evidence states: 'Remarkably, the presence of ADAM-8 both on the cell surface and in suspension increased the ectodomain shedding of membrane-bound L-selectin in mammalian cells.' Identify the biological pro... | regulation of cell adhesion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03011","source_qa_id":"medium_divergent_branch_05896","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ADAM8 is associated with multiple biological processes via the 'involved in' relationship. One sp... | |
medium_divergent_branch_03012 | BAP1 interacts with multiple proteins. One interaction involves a partner that, along with another transcription factor, binds to BAP1, yet the mechanism by which BAP1 controls gene expression through this interaction remains unclear. Which protein is encoded by the gene corresponding to this specific interaction partn... | Forkhead box protein K1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03012","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BAP1 interacts with multiple proteins. One interaction involves a partner that, along with another transcription factor, binds to BAP1, yet the mecha... | |
medium_divergent_branch_03013 | PAFAH1B1 interacts with multiple proteins. One of these interaction partners is characterized by the following evidence: 'While its phosphorylation triggers chromatin exclusion, it promotes binding to actin regulators and to two previously unrecognized specific substrate receptors (DCAFs), LIS1 and WDR1.' Which protein... | Cullin-4B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03013","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAFAH1B1 interacts with multiple proteins. One of these interaction partners is characterized by the following evidence: 'While its phosphorylation t... | |
medium_divergent_branch_03014 | TRIM38 interacts with multiple proteins. One interaction is characterized by the following mechanism: the interacting partner directly binds to galectin-3-binding protein (LGALS3BP) and forms a complex with the E3 ubiquitin ligase TRIM38, facilitating the ubiquitination-mediated degradation of LGALS3BP at the K104 resi... | Ubiquitin-conjugating enzyme E2 G2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03014","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM38 interacts with multiple proteins. One interaction is characterized by the following mechanism: the interacting partner directly binds to galec... | |
medium_divergent_branch_03015 | The SKI protein interacts with multiple partners. One interaction is characterized by the following evidence: 'This stimulation of MDM2 sumoylation is accomplished through a direct interaction of SKI with SUMO-conjugating enzyme E2, [REDACTED], resulting in enhanced thioester bond formation and mono-sumoylation of [RED... | SUMO-conjugating enzyme UBC9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03015","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The SKI protein interacts with multiple partners. One interaction is characterized by the following evidence: 'This stimulation of MDM2 sumoylation i... | |
medium_divergent_branch_03016 | KRT18 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have now identified human TNF receptor type 1 (TNFR1)-associated death domain protein to be the K18-interacting protein.' Which protein is encoded by the gene corresponding to this interaction partner? | Tumor necrosis factor receptor type 1-associated DEATH domain protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03016","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KRT18 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have now identified human TNF receptor type 1 (TNFR1)-a... | |
medium_divergent_branch_03017 | hsa-miR-17-3p is reported to regulate more than one cell type. One specific regulatory context involves miRNAs from the miR-17-92 paralog clusters being upregulated by a specific cell type during the germinal center (GC) differentiation stage. Which anatomical domain is that specific cell type part of? | B cell domain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03017","source_qa_id":"medium_divergent_branch_02053","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"hsa-miR-17-3p is reported to regulate more than one cell type. One specific regulatory context in... | |
medium_divergent_branch_03018 | NDC80 interacts with multiple proteins. One of these interaction partners is reported to interact with HEC1 (the human homolog of yeast Ndc80) throughout the cell cycle and localize to kinetochores during mitosis. Which protein, encoded by the gene corresponding to this interaction partner, is the target of the 'encode... | Kinetochore protein Spc25 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03018","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NDC80 interacts with multiple proteins. One of these interaction partners is reported to interact with HEC1 (the human homolog of yeast Ndc80) throug... | |
medium_divergent_branch_03019 | FBXO7 interacts with multiple genes. One of these interaction partners is described as participating in mitochondrial maintenance through direct interaction with FBXO7 and Parkin, acting in Parkin-mediated mitophagy. Which disease is connected to this specific interaction partner through a biomarker relationship? | Ischemic stroke | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03019","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO7 interacts with multiple genes. One of these interaction partners is described as participating in mitochondrial maintenance through direct inte... | |
medium_divergent_branch_03020 | E2F4 interacts with multiple proteins. One specific interaction is characterized by an extensive protein-protein interface where structural features suggest a preference for heterodimers over homodimers in DNA binding. Which protein, encoded by the gene linked to E2F4 via this specific interaction, is the subject of th... | Transcription factor Dp-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03020","source_qa_id":"medium_divergent_branch_03255","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"E2F4 interacts with multiple proteins. One specific interaction is characterized by an extensive ... | |
medium_divergent_branch_03021 | ULK4 is associated with multiple biological processes. One association is supported by evidence stating that knockdown of ULK4 disrupts microtubule composition and compromises neuritogenesis and cell motility. Which broader biological process is a parent term (via an 'is a' relationship) of the specific process linked ... | regulation of cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03021","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ULK4 is associated with multiple biological processes. One association is supported by evidence stating that knockdown of ULK4 disrupts microtubule c... | |
medium_divergent_branch_03022 | UCHL1 interacts with multiple proteins. One of these interaction partners protects BCL6 from ubiquitin-mediated proteasomal degradation by the E3-ubiquitin ligase FBXO11 by binding to the deubiquitinase UCHL1, thereby helping to maintain BCL6 expression. Which protein is encoded by the gene corresponding to this specif... | AH receptor-interacting protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03022","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UCHL1 interacts with multiple proteins. One of these interaction partners protects BCL6 from ubiquitin-mediated proteasomal degradation by the E3-ubi... | |
medium_divergent_branch_03025 | EPHB3 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'We found that rasGAP, Crk and Fyn bind in a SH2-dependent manner to autophosphorylated HEK2.' Which protein is encoded by the gene corresponding to this specific interaction partner? | Ras GTPase-activating protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03025","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EPHB3 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'We found that rasGAP, Crk and Fyn bind in a... | |
medium_divergent_branch_03026 | PTPRB is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Quantitative BiFC analysis, using a VE-PTP construct expressing only the ectodomain and transmembrane domain, revealed a specific interaction with VE-cadherin.' Which molecul... | cell adhesion molecule binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03026","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTPRB is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Qua... | |
medium_divergent_branch_03027 | PDGFRB interacts with multiple proteins. One interaction is supported by evidence stating: 'Our data provide the first evidence that this protein is physically associated with platelet-derived growth factor (PDGF) receptor and that PDGF causes its dissociation from the receptor.' What is the full name of the protein en... | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03027","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDGFRB interacts with multiple proteins. One interaction is supported by evidence stating: 'Our data provide the first evidence that this protein is ... | |
medium_divergent_branch_03028 | MAPK1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'In this study, we demonstrated interactions between ERK2 and topoisomerase IIalpha proteins by coimmunoprecipitation from mixtures of purified enzymes and from nuclear extracts.' Which protein is encoded by the gene that i... | DNA topoisomerase 2-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03028","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'In this study, we demonstrated interactions between... | |
medium_divergent_branch_03030 | The innate immune response is mediated by multiple cell types. One such cell type is described as a T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation. Which broader cell category does this specific cell type belong to? | effector T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03030","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The innate immune response is mediated by multiple cell types. One such cell type is described as a T cell with a receptor of limited diversity that ... | |
medium_divergent_branch_03033 | GJA1 interacts with multiple proteins. One specific interaction is described as occurring between Cx43 and a tight junction scaffolding protein, mediated by the extreme carboxyl terminus of Cx43 and the second PDZ domain of that scaffolding protein. Which protein, encoded by the gene corresponding to this specific inte... | Tight junction protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03033","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GJA1 interacts with multiple proteins. One specific interaction is described as occurring between Cx43 and a tight junction scaffolding protein, medi... | |
medium_divergent_branch_03034 | MEF2C interacts with multiple proteins. One specific interaction is characterized by evidence from Glutathione S-transferase pulldown and immunoprecipitation experiments, which demonstrate that the repression mechanism involves direct interactions between MEF2 proteins and the target protein. This interaction is associ... | Histone deacetylase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03034","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MEF2C interacts with multiple proteins. One specific interaction is characterized by evidence from Glutathione S-transferase pulldown and immunopreci... | |
medium_divergent_branch_03035 | PSEN1 interacts with multiple proteins. One interaction is characterized by a highly conserved binding site (PxExxAr/Ac) in presenilin-1 that mediates nerve growth factor (NGF)-induced association between PS1 and the interacting protein. Which protein, connected to PSEN1 via an interaction, is encoded by the gene in qu... | TNF receptor-associated factor 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03035","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSEN1 interacts with multiple proteins. One interaction is characterized by a highly conserved binding site (PxExxAr/Ac) in presenilin-1 that mediate... | |
medium_divergent_branch_03037 | DNTTIP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We isolated human cDNA clone encoding a gene with a product that binds to TdT interacting factor 1 (TdIF1) using a yeast two-hybrid system.' Which protein, connected to DNTTIP1 via this specific evidence, is encoded by the gene... | Ankyrin repeat and BTB/POZ domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03037","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNTTIP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We isolated human cDNA clone encoding a gene with a prod... | |
medium_divergent_branch_03038 | WNT2 is associated with multiple biological processes. One specific association is supported by evidence stating that purified Wnt2 increases progenitor proliferation and the number of dopaminergic neurons in ventral midbrain precursor cultures. Which biological process, connected to this specific WNT2-associated proce... | neural precursor cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03038","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT2 is associated with multiple biological processes. One specific association is supported by evidence stating that purified Wnt2 increases progeni... | |
medium_divergent_branch_03039 | The protein CFAP69 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Our experimental findings elucidate that homozygous loss-of-function mutations in CFAP69 can lead to asthenoteratospermia with MMAF in humans and mice.' Identify the cell type that enables th... | flagellated sperm cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03039","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CFAP69 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Our experimental fin... | |
medium_divergent_branch_03040 | PRKAR1A interacts with multiple proteins. One interaction is supported by evidence stating: 'Both RIalpha- and RIbeta homodimers as well as an RIalpha:RIbeta heterodimer were observed.' Which protein, connected to PRKAR1A via this specific interaction, encodes a regulatory subunit? | cAMP-dependent protein kinase type I-beta regulatory subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03040","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKAR1A interacts with multiple proteins. One interaction is supported by evidence stating: 'Both RIalpha- and RIbeta homodimers as well as an RIalph... | |
medium_divergent_branch_03041 | MXD1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that like Mad1, the HBP1 transrepression domain binds through a helical structure to the hydrophobic cleft of mSin3A PAH2.' Which disease is associated with the protein described in this evidence via a biomarker relationsh... | leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03041","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MXD1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that like Mad1, the HBP1 transrepression domain bin... | |
medium_divergent_branch_03042 | hsa-miR-199b-5p regulates more than one cell type. Evidence for one of these regulatory connections notes that the increase of miR-199b-5p in erythroid cells occurred in a GATA-1- and NF-E2-dependent manner during the maturation of a specific red blood cell type. Which cell type, connected to the cell indicated by this... | reticulocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03042","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-199b-5p regulates more than one cell type. Evidence for one of these regulatory connections notes that the increase of miR-199b-5p in erythro... | |
medium_divergent_branch_03043 | AP1G1 is involved in multiple biological processes. One of these processes is supported by evidence stating that disruption of the AP-1 sorting complex (a LAMP1 binding partner) causes retention of perforin in transport vesicles and inhibits cytotoxicity. Which biological process is positively regulated by this specifi... | natural killer cell mediated cytotoxicity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03043","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AP1G1 is involved in multiple biological processes. One of these processes is supported by evidence stating that disruption of the AP-1 sorting compl... | |
medium_divergent_branch_03044 | The gene EED interacts with multiple partners. One interaction is supported by evidence stating: 'Although three subunits, EZH1/2, the shared gene, and EED, form the catalytic core of PRC2, a wider group of proteins associate with low stoichiometry.' Which protein is encoded by the gene that binds to EED and is mention... | Polycomb protein SUZ12 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03044","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EED interacts with multiple partners. One interaction is supported by evidence stating: 'Although three subunits, EZH1/2, the shared gene, a... | |
medium_divergent_branch_03045 | MDM4 interacts with multiple proteins. One interaction is supported by evidence stating: 'This degradation appears to be mediated by the 26S proteasome, as MDMX and p21 bound to a specific subunit of the 19S component of the 26S proteasome, in vivo.' Which protein, encoded by the gene connected to MDM4 via this specifi... | 26S proteasome non-ATPase regulatory subunit 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03045","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MDM4 interacts with multiple proteins. One interaction is supported by evidence stating: 'This degradation appears to be mediated by the 26S proteaso... | |
medium_divergent_branch_03046 | Clusterin (CLU) interacts with multiple proteins. One interaction partner is associated with vesicular components involved in red blood cell senescence, such as Band 3, CD59, hemoglobin, and carbonylated membrane proteins. Which protein, encoded by a gene that interacts with CLU, corresponds to this description? | Band 3 anion transport protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03046","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Clusterin (CLU) interacts with multiple proteins. One interaction partner is associated with vesicular components involved in red blood cell senescen... | |
medium_divergent_branch_03047 | SHC1 interacts with multiple genes. One interaction is supported by evidence stating: 'The interaction of a MAPKAPK2 alias with the 66 kDa isoform of ShcA, p66(ShcA), and HPH2 was confirmed using co-immunoprecipitation.' Which disease is associated with the gene identified in this specific interaction via a biomarker r... | Alzheimer disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03047","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SHC1 interacts with multiple genes. One interaction is supported by evidence stating: 'The interaction of a MAPKAPK2 alias with the 66 kDa isoform of... | |
medium_divergent_branch_03048 | UBE2O interacts with multiple proteins. One interaction is supported by evidence stating: 'Our study also identified a protein, also known as Caveolin-associated Protein-2, interacted with both UBE2O and PTRF.' Which protein is encoded by the gene corresponding to this interaction partner? | Caveolae-associated protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03048","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2O interacts with multiple proteins. One interaction is supported by evidence stating: 'Our study also identified a protein, also known as Caveoli... | |
medium_divergent_branch_03049 | CECR2 is associated with multiple biological processes. One association is supported by evidence that GFP-tagged CECR2 is strictly nuclear and colocalizes with condensed DNA in apoptotic cells. Which biological process, connected to the process supported by this evidence via an 'is a' relationship, is the correct answe... | DNA catabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03049","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CECR2 is associated with multiple biological processes. One association is supported by evidence that GFP-tagged CECR2 is strictly nuclear and coloca... | |
medium_divergent_branch_03050 | The gene DUSP16 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 4.31 TPM, a z-score of 2.54, and a fold enrichment of 7.67. Which cell type, connected to DUSP16 via this specific enrichment evidence, is a subtype of mature T cells? | mature T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03050","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DUSP16 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 4.31 TPM, a ... | |
medium_divergent_branch_03052 | GATA1 interacts with multiple proteins. One specific interaction involves a protein isoform that, unlike other detected isoforms of the same gene, directly binds GATA-1 and recruits it into nuclear bodies associated with that protein. Which protein is encoded by the gene corresponding to this interacting partner? | Protein PML | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03052","source_qa_id":"medium_divergent_branch_05084","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GATA1 interacts with multiple proteins. One specific interaction involves a protein isoform that,... | |
medium_divergent_branch_03053 | The gene EFCAB15P is enriched in multiple cell types. One specific enrichment profile is characterized by a mean expression of 9.85 TPM, a z-score of 1.89, and a fold enrichment of 4.86. Identify the precursor cell type from which the cell exhibiting this specific expression profile develops. | mature CD8 single-positive thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03053","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EFCAB15P is enriched in multiple cell types. One specific enrichment profile is characterized by a mean expression of 9.85 TPM, a z-score of... | |
medium_divergent_branch_03054 | BIN1 is associated with multiple biological processes. One association is supported by evidence stating: 'Our studies suggest that Bin1 overexpression in neuroblastoma and astrocytoma cells can result in one of the following pathways: (1) suppressed cell proliferation, (2) induced differentiation, or (3) apoptosis.' Wh... | neuron differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03054","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BIN1 is associated with multiple biological processes. One association is supported by evidence stating: 'Our studies suggest that Bin1 overexpressio... | |
medium_divergent_branch_03055 | Ivabradine has a documented interaction with a specific drug. Evidence regarding this interaction notes that 'The most significant changes for inhibition and induction were observed with rolapitant, a moderate inhibitor of CYP2D6 and this drug, a strong inducer of CYP3A.' Which disease is this drug indicated for? | cystic fibrosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03055","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Ivabradine has a documented interaction with a specific drug. Evidence regarding this interaction notes that 'The most significant changes for inhibi... | |
medium_divergent_branch_03056 | SDC2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report the identification of a protein that binds to the cytoplasmic domains of the syndecans in yeast two-hybrid screens, surface plasmon resonance experiments, and ligand-overlay assays.' Which protein product is encoded... | Syntenin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03056","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SDC2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report the identification of a protein that binds t... | |
medium_divergent_branch_03057 | TNFRSF13C (BAFF-R) interacts with multiple proteins. One specific interaction is supported by evidence stating that coimmunoprecipitation experiments indicated BAFF-R interacts with this partner in B lymphoma cells, and this interaction is stimulated by TALL-1 treatment. Which disease is associated with this interactio... | plasma cell myeloma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03057","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNFRSF13C (BAFF-R) interacts with multiple proteins. One specific interaction is supported by evidence stating that coimmunoprecipitation experiments... | |
medium_divergent_branch_03058 | CCAR2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Mechanistically, hypoxia promoted DBC1 to interact with this protein but not OTUD5, resulting in the ubiquitination and subsequent degradation of DBC1 through the ubiquitin-proteasome pathway.' What is the name of the pr... | E3 ubiquitin-protein ligase SIAH2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03058","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCAR2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Mechanistically, hypoxia promoted DBC1 to interac... | |
medium_divergent_branch_03059 | RHOA is associated with multiple biological processes. One association is supported by evidence that ODAM-mediated RhoA signaling resulted in actin filament rearrangement. Which biological process, connected to the process supported by this evidence, is linked via a 'regulates' relationship? | actin cytoskeleton organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03059","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RHOA is associated with multiple biological processes. One association is supported by evidence that ODAM-mediated RhoA signaling resulted in actin f... | |
medium_divergent_branch_03060 | MAPK14 interacts with multiple proteins. One interaction is supported by evidence stating: 'Remarkably, exchange of two amino acids in this site of ERK2 for corresponding residues of p38 converted the docking specificity for a specific kinase target, which is a dominant target of p38, from the ERK2 type to the p38 type... | MAP kinase-activated protein kinase 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03060","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK14 interacts with multiple proteins. One interaction is supported by evidence stating: 'Remarkably, exchange of two amino acids in this site of E... |
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