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medium_divergent_branch_03061 | SPG21 interacts with multiple proteins. One of these interaction partners was identified in a two-hybrid screen using the intracellular portion of the protein, which revealed a previously unknown 33-kDa protein, ACP33 (acidic cluster protein 33), as a novel intracellular binding partner. Which protein is this interacti... | T-cell surface glycoprotein CD4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03061","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SPG21 interacts with multiple proteins. One of these interaction partners was identified in a two-hybrid screen using the intracellular portion of th... | |
medium_divergent_branch_03063 | GARS1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Interestingly, the N-terminal extension of human glycyl-tRNA synthetase containing a single motif homologous to those in the bifunctional tRNA synthetase also interacted with the C-terminal motif of the isoleucyl-tRNA synthetase ... | Isoleucine--tRNA ligase, cytoplasmic | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03063","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GARS1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Interestingly, the N-terminal extension of human glycyl-tR... | |
medium_divergent_branch_03064 | TXNIP interacts with multiple genes. One of these interactions is mediated by the PPXY motifs of TXNIP and the WW domains of the interacting partner. Which disease is associated with this specific interacting partner? | syndromic multisystem autoimmune disease due to ITCH deficiency | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03064","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TXNIP interacts with multiple genes. One of these interactions is mediated by the PPXY motifs of TXNIP and the WW domains of the interacting partner.... | |
medium_divergent_branch_03066 | The protein EBP interacts with multiple partners. One specific interaction is supported by evidence stating: 'By coimmunprecipitation and colocalisation experiments, we were able to demonstrate evidence for the interaction of these proteins.' Which protein product is encoded by the gene corresponding to this specific i... | Vitamin K epoxide reductase complex subunit 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03066","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein EBP interacts with multiple partners. One specific interaction is supported by evidence stating: 'By coimmunprecipitation and colocalisat... | |
medium_divergent_branch_03067 | SLC7A11 interacts with multiple proteins. One interaction is supported by evidence from a mechanistic study (PMID:37422058) using Affinity Capture-Western, which revealed that the interacting partner had endogenous interactions with SLC7A11 proteins. What is the full protein name encoded by this interacting partner? | E3 ubiquitin-protein ligase HECTD3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03067","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLC7A11 interacts with multiple proteins. One interaction is supported by evidence from a mechanistic study (PMID:37422058) using Affinity Capture-We... | |
medium_divergent_branch_03068 | HIST1H2BB interacts with multiple proteins. One of these interaction partners is described as binding to and protecting histone H2B from monoubiquitination by RNF20/RNF40 at DNA break-sites. Which protein is encoded by the gene corresponding to this specific interaction partner? | COMM domain-containing protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03068","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIST1H2BB interacts with multiple proteins. One of these interaction partners is described as binding to and protecting histone H2B from monoubiquiti... | |
medium_divergent_branch_03069 | The SMN1 gene interacts with multiple protein-coding genes. One such interaction is supported by evidence stating: 'Significantly, the interacting protein directly interacted with SMN protein, as determined by immunoprecipitation and immunofluorescence assays in P19 and NSC34 cells.' Which protein is encoded by the gen... | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03069","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The SMN1 gene interacts with multiple protein-coding genes. One such interaction is supported by evidence stating: 'Significantly, the interacting pr... | |
medium_divergent_branch_03070 | FYN interacts with multiple proteins. One interaction is characterized by evidence stating that Fyn associates with the partner protein, and that loss of Fyn results in reduced phosphorylation of that partner. Which protein, connected to the FYN gene via an 'encodes' relationship, fits this description? | E3 ubiquitin-protein ligase Itchy homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03070","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FYN interacts with multiple proteins. One interaction is characterized by evidence stating that Fyn associates with the partner protein, and that los... | |
medium_divergent_branch_03071 | AQP1 is associated with multiple biological processes. One association is supported by evidence stating: 'Taken together, AQP1 in human TM appears to serve a protective role by facilitating improved cell viability during conditions of mechanical strain.' Which biological process, connected to the process described by t... | homeostatic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03071","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AQP1 is associated with multiple biological processes. One association is supported by evidence stating: 'Taken together, AQP1 in human TM appears to... | |
medium_divergent_branch_03072 | DAB2IP is associated with multiple biological processes. One association is supported by evidence stating: 'Here, we show that the loss of DAB2IP expression initiates epithelial-to-mesenchymal transition (EMT), which is visualized by repression of E-cadherin and up-regulation of vimentin in both human normal prostate e... | epithelial cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03072","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DAB2IP is associated with multiple biological processes. One association is supported by evidence stating: 'Here, we show that the loss of DAB2IP exp... | |
medium_divergent_branch_03073 | The gene ADRB3 is associated with multiple biological processes. One association is supported by evidence stating: 'These results demonstrate that beta3-adrenoceptor stimulation decreases cardiac contractility through activation of an NOS pathway.' Identify the biological process that is negatively regulated by the spe... | cardiac muscle contraction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03073","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ADRB3 is associated with multiple biological processes. One association is supported by evidence stating: 'These results demonstrate that be... | |
medium_divergent_branch_03074 | The gene FANCC interacts with multiple other genes via protein-protein binding. One of these interacting partners is a protein that functions as a component of a nuclear protein complex containing both FANCA and FANCC. Which protein is encoded by this interacting gene? | Fanconi anemia group G protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03074","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FANCC interacts with multiple other genes via protein-protein binding. One of these interacting partners is a protein that functions as a co... | |
medium_divergent_branch_03075 | The axon terminus is a type of cellular component. Evidence for one of its parent categories describes it as the 'Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters,' noting that this entity represents the whole region of thickening, of which the terminal ... | neuron projection | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03075","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The axon terminus is a type of cellular component. Evidence for one of its parent categories describes it as the 'Terminal inflated portion of the ax... | |
medium_divergent_branch_03076 | NBR1 interacts with multiple proteins. One of these interaction partners is described as binding to proteins involved in ubiquitin-mediated protein turnover and vesicle trafficking, specifically ubiquitin-specific peptidases and the endosomal transport regulator p14/Robld3. Which protein, connected to NBR1 via an inter... | Ubiquitin carboxyl-terminal hydrolase 8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03076","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NBR1 interacts with multiple proteins. One of these interaction partners is described as binding to proteins involved in ubiquitin-mediated protein t... | |
medium_divergent_branch_03077 | The gene MYB interacts with multiple partners. One specific interaction involves a protein that, together with HIPK2, binds directly to c-Myb and phosphorylates it at multiple sites, thereby inducing its ubiquitination and proteasome-dependent degradation. Which protein is encoded by the gene connected to MYB through t... | Serine/threonine-protein kinase NLK | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03077","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene MYB interacts with multiple partners. One specific interaction involves a protein that, together with HIPK2, binds directly to c-Myb and pho... | |
medium_divergent_branch_03078 | The gene ADRA2C is involved in multiple biological processes. One specific process is supported by evidence stating that both alpha2A- and alpha2C-subtypes are required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. Which biological pro... | norepinephrine secretion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03078","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ADRA2C is involved in multiple biological processes. One specific process is supported by evidence stating that both alpha2A- and alpha2C-su... | |
medium_divergent_branch_03081 | CD177 is associated with multiple biological processes. One association is supported by evidence that monoclonal antibodies against CD177 and against PECAM-1 domain 6 inhibited the adhesion of U937 cells stably expressing CD177 to immobilized PECAM-1. Which biological process, connected to the process supported by this... | cell-cell adhesion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03081","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD177 is associated with multiple biological processes. One association is supported by evidence that monoclonal antibodies against CD177 and against... | |
medium_divergent_branch_03082 | TNIP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'When overexpressed in cells, ABIN-2 bound to IKKgamma and prevented the association of IKKgamma with RIP.' Which protein product is encoded by the TNIP2-interacting partner described in this evidence? | NF-kappa-B essential modulator | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03082","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNIP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'When overexpressed in cells, ABIN-2 bound to IKKgamma and ... | |
medium_divergent_branch_03083 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.588 and an adjusted p-value of 0.0493. Which protein does that selected gene encode? | Epithelial sodium channel subunit beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03083","source_qa_id":"medium_divergent_branch_07446","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_03084 | MIR16-1 is associated with multiple biological processes. One association is supported by evidence that miR-16 overexpression reduces endothelial cell proliferation, migration, and cord formation in vitro, and impairs blood vessel formation in vivo. Which biological process is negatively regulated by the process linked... | angiogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03084","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR16-1 is associated with multiple biological processes. One association is supported by evidence that miR-16 overexpression reduces endothelial cel... | |
medium_divergent_branch_03088 | RSPO1 is known to bind to multiple proteins. One specific interaction is characterized by the following mechanism: R-spondin interacts with the extracellular domain of the target protein and induces its association with LGR4, resulting in the membrane clearance of the target protein. Which protein, connected to RSPO1 v... | E3 ubiquitin-protein ligase ZNRF3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03088","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RSPO1 is known to bind to multiple proteins. One specific interaction is characterized by the following mechanism: R-spondin interacts with the extra... | |
medium_divergent_branch_03089 | DLG1 interacts with multiple genes. One interaction is supported by evidence stating: 'In the present study, we found that 5-HT2AR interacts with synapse-associated protein 97 (SAP97; also known as DLG1) by coimmunoprecipitation in human embryonic 293 (HEK 293) cells and cortical brain lysates.' Which disease is geneti... | eclampsia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03089","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLG1 interacts with multiple genes. One interaction is supported by evidence stating: 'In the present study, we found that 5-HT2AR interacts with syn... | |
medium_divergent_branch_03090 | NOX5 is associated with multiple biological processes. One association is supported by evidence stating that NOX5 is likely involved in Ca(2+)-activated, redox-dependent processes in spermatozoa and lymphocytes, including sperm-oocyte fusion, cell proliferation, and cytokine secretion. Which biological process, connect... | cytokine production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03090","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOX5 is associated with multiple biological processes. One association is supported by evidence stating that NOX5 is likely involved in Ca(2+)-activa... | |
medium_divergent_branch_03091 | PPP4C interacts with multiple genes. One interaction is supported by evidence that PP4 physically interacted with the partner and was recruited to the TLR4 complex upon LPS stimulation. Which cell type is the partner gene enriched in? | basophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03091","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPP4C interacts with multiple genes. One interaction is supported by evidence that PP4 physically interacted with the partner and was recruited to th... | |
medium_divergent_branch_03094 | CLASRP interacts with multiple genes. One interaction is supported by evidence stating: 'In vitro protein interaction assay demonstrated that the K189R mutant of this gene product was bound to Clasp while the wild type was not.' Which gene is connected to CLASRP through this specific interaction? | UBL5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03094","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLASRP interacts with multiple genes. One interaction is supported by evidence stating: 'In vitro protein interaction assay demonstrated that the K18... | |
medium_divergent_branch_03095 | RAB4A interacts with multiple proteins. One interaction is supported by evidence stating: 'We have identified a novel 80-kDa protein that interacts specifically with the GTP-bound conformation of Rab4, and subsequent work has shown that it also interacts strongly with Rab11.' Which protein, connected to RAB4A via this ... | Rab11 family-interacting protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03095","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB4A interacts with multiple proteins. One interaction is supported by evidence stating: 'We have identified a novel 80-kDa protein that interacts s... | |
medium_divergent_branch_03096 | The gene CCT3 is reported to interact with multiple proteins. One specific interaction is described by the following evidence: 'pVHL formed a complex with the cytosolic chaperonin containing TCP-1 (CCT or TRiC) en route to assembly with elongin B/C and the subsequent formation of the VCB-Cul2 ubiquitin ligase.' Based o... | von Hippel-Lindau disease tumor suppressor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03096","source_qa_id":"medium_divergent_branch_01612","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene CCT3 is reported to interact with multiple proteins. One specific interaction is describ... | |
medium_divergent_branch_03097 | NACC1 interacts with multiple proteins. One interaction involves a partner that forms an E3 ubiquitin ligase complex with NAC1 to promote the ubiquitination and degradation of Cyclin B1, thereby facilitating mitotic exit and leading to cellular resistance to docetaxel. Which protein is encoded by the gene corresponding... | Cullin-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03097","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NACC1 interacts with multiple proteins. One interaction involves a partner that forms an E3 ubiquitin ligase complex with NAC1 to promote the ubiquit... | |
medium_divergent_branch_03100 | The MYOCD gene is associated with multiple biological processes. One specific association is supported by evidence stating that Myocardin is a transcriptional regulator of cardiac and smooth muscle development. Considering this evidence, which biological process linked to MYOCD via 'involved in' leads to the acquisitio... | smooth muscle cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03100","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The MYOCD gene is associated with multiple biological processes. One specific association is supported by evidence stating that Myocardin is a transc... | |
medium_divergent_branch_03101 | PPARG interacts with multiple genes. One specific interaction is supported by evidence stating that IL-4 signaling augmented PPARγ activity through an interaction between PPARγ and signal transducer and activators of transcription 6 on promoters of PPARγ target genes, including FABP4. Which disease is connected to this... | scleroderma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03101","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPARG interacts with multiple genes. One specific interaction is supported by evidence stating that IL-4 signaling augmented PPARγ activity through a... | |
medium_divergent_branch_03102 | USP22 interacts with multiple genes. One of these interaction partners forms a complex with ENY2 that, unlike the ATXN7L3 DUB complex, cannot efficiently deubiquitinate H2Bub1 in vitro. Which cellular component is the gene encoding this specific interaction partner located in? | cytoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03102","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP22 interacts with multiple genes. One of these interaction partners forms a complex with ENY2 that, unlike the ATXN7L3 DUB complex, cannot efficie... | |
medium_divergent_branch_03103 | SIRPA interacts with multiple genes. One interaction is supported by evidence stating: 'Using a yeast two-hybrid screen, we identified a protein tyrosine kinase, Csk-homologous kinase, as an SHPS-1-interacting protein.' Which disease is associated with the gene identified in this specific interaction? | malaria | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03103","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIRPA interacts with multiple genes. One interaction is supported by evidence stating: 'Using a yeast two-hybrid screen, we identified a protein tyro... | |
medium_divergent_branch_03104 | The gene NR5A1 is involved in multiple biological processes. One of these processes is linked to evidence stating that mutations in NR5A1 in 46,XX women are associated with primary ovarian insufficiency, characterized by a lack of ovary formation, primary and secondary amenorrhea, and early menopause. Which biological ... | development of primary female sexual characteristics | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03104","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NR5A1 is involved in multiple biological processes. One of these processes is linked to evidence stating that mutations in NR5A1 in 46,XX wo... | |
medium_divergent_branch_03106 | MID2 interacts with multiple proteins. One of these interaction partners is an E3 ubiquitin ligase, for which experimental evidence confirms interactions with MID2, TRIM1, and TRIM27. Which protein, encoded by the gene corresponding to this specific E3 ligase partner, is connected to MID2? | E3 ubiquitin-protein ligase LNX | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03106","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MID2 interacts with multiple proteins. One of these interaction partners is an E3 ubiquitin ligase, for which experimental evidence confirms interact... | |
medium_divergent_branch_03107 | The gene IFT54 (also known as TRAF3IP1) interacts with multiple partners. One specific interaction partner is identified in a study stating: 'Three MIP-T3-interacted proteins - actin, this protein and tubulin - were further confirmed by reciprocal coimmunoprecipitations and colocalization analysis.' Which disease is as... | carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03107","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IFT54 (also known as TRAF3IP1) interacts with multiple partners. One specific interaction partner is identified in a study stating: 'Three M... | |
medium_divergent_branch_03108 | SHANK1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'By using the yeast two-hybrid system we identified a novel protein from the human brain interacting with the C terminus of somatostatin receptor subtype 2.' Which protein is encoded by the gene that interacts with SHANK1 ... | Somatostatin receptor type 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03108","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SHANK1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'By using the yeast two-hybrid system we identified... | |
medium_divergent_branch_03109 | SLC9A1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In a genetic screen, NHE1 interacted with a specific kinase at a site N-terminal (amino acids 407-502) to the Nck-binding domain, and this site is critical for its association with NHE1 in vivo.' Which protein, connected to SLC9... | Mitogen-activated protein kinase kinase kinase 14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03109","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLC9A1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In a genetic screen, NHE1 interacted with a specific kina... | |
medium_divergent_branch_03110 | GSDMD is associated with multiple biological processes. One specific association is supported by evidence stating that mutation of the acidic residues of GSDMD compromises a preference, thereby hindering the intracellular retention of the precursor and the secretion of the mature cytokine. Which cell type is linked to ... | protein secreting cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03110","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GSDMD is associated with multiple biological processes. One specific association is supported by evidence stating that mutation of the acidic residue... | |
medium_divergent_branch_03111 | The gene NR2C1 is reported to interact with multiple proteins. One specific interaction is supported by evidence stating: 'Using GST pull-downs, both HDACs 3 and 4 were found to interact directly with the core DBD from each receptor.' Identify the protein encoded by the gene that interacts with NR2C1 according to this ... | Histone deacetylase 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03111","source_qa_id":"medium_divergent_branch_02533","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene NR2C1 is reported to interact with multiple proteins. One specific interaction is suppor... | |
medium_divergent_branch_03112 | TPX2 is associated with multiple biological processes. One specific association is supported by evidence stating that human TPX2 directly stabilizes growing microtubule ends and stimulates the process by stabilizing early intermediates. Which biological process is a parent term (is_a) of this specific process? | microtubule cytoskeleton organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03112","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TPX2 is associated with multiple biological processes. One specific association is supported by evidence stating that human TPX2 directly stabilizes ... | |
medium_divergent_branch_03113 | ATF3 interacts with multiple gene products. One specific interaction is supported by evidence stating: 'As confirmed by the GST pull-down assay, ATF3 bound to the DNA-binding domain of a p53 family member, resulting in the activation of p21 or Bax transcription, a downstream target of this protein.' Which protein is en... | Tumor protein p73 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03113","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATF3 interacts with multiple gene products. One specific interaction is supported by evidence stating: 'As confirmed by the GST pull-down assay, ATF3... | |
medium_divergent_branch_03114 | The gene ESAM is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 15.80 TPM, a z-score of 2.45, and a fold enrichment of 9.41. Which anatomical structure is the cell type associated with these specific statistics a part of? | blood | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03114","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ESAM is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 15.80 TPM, a z... | |
medium_divergent_branch_03115 | Perivascular macrophages are anatomically associated with multiple structures via a 'part of' relationship. One such structure is described as a dense region demarcating the thymus medulla from the surrounding cortex, characterized by numerous blood vessels (predominantly arterioles), perivascular connective tissue, ma... | arteriole | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03115","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Perivascular macrophages are anatomically associated with multiple structures via a 'part of' relationship. One such structure is described as a dens... | |
medium_divergent_branch_03116 | GADD45A interacts with multiple genes. One of these interaction partners is a protein that interacts with elongation factor 1alpha (EF-1alpha), a microtubule-severing protein crucial for cytoskeletal stability. This partner inhibits EF-1alpha-mediated microtubule bundling, thereby disrupting cytoskeletal stability. Whi... | Lyme disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03116","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GADD45A interacts with multiple genes. One of these interaction partners is a protein that interacts with elongation factor 1alpha (EF-1alpha), a mic... | |
medium_divergent_branch_03117 | MORF4L1 interacts with multiple proteins. One of these interaction partners was identified, along with MORF4L1, as being among the most up-regulated proteins following NEDD8 inhibition in multiple human cell lines. Which protein is encoded by the gene corresponding to this specific interaction partner? | MORF4 family-associated protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03117","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MORF4L1 interacts with multiple proteins. One of these interaction partners was identified, along with MORF4L1, as being among the most up-regulated ... | |
medium_divergent_branch_03118 | The transcription factor SRF interacts with multiple genes. One specific interaction is supported by evidence stating that the C-terminal region of a nuclear receptor corepressor directly interacted with SRF, as well as AP-1 components (c-Jun, c-Fos) and NF-kappaB components (p50, p65), demonstrated via yeast/mammalian... | polyarticular arthritis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03118","source_qa_id":"medium_divergent_branch_05005","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The transcription factor SRF interacts with multiple genes. One specific interaction is supported... | |
medium_divergent_branch_03119 | PRUNE1 is associated with multiple biological processes. One association is supported by evidence stating: 'Together these studies define PRUNE as a molecule fundamental for normal human cortical development and define cellular and clinical consequences associated with PRUNE mutation.' Which biological process, connect... | neurogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03119","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRUNE1 is associated with multiple biological processes. One association is supported by evidence stating: 'Together these studies define PRUNE as a ... | |
medium_divergent_branch_03120 | JMJD1C interacts with multiple proteins. One of these interaction partners is characterized by evidence showing that JMJD1C was stabilized by the interaction, recruited to DNA double-strand breaks (DSBs), and required for local ubiquitylations and the recruitment of the RAP80-BRCA1 complex, but not 53BP1. Which protein... | E3 ubiquitin-protein ligase RNF8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03120","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JMJD1C interacts with multiple proteins. One of these interaction partners is characterized by evidence showing that JMJD1C was stabilized by the int... | |
medium_divergent_branch_03121 | PRKACA interacts with multiple proteins. One interaction is supported by evidence stating: 'We interrogated compound libraries using this assay in combination with a counter-screen based on luciferase complementation by the two subunits of protein kinase A (PKA).' Which protein, connected to PRKACA via this specific ev... | cAMP-dependent protein kinase type II-alpha regulatory subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03121","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKACA interacts with multiple proteins. One interaction is supported by evidence stating: 'We interrogated compound libraries using this assay in co... | |
medium_divergent_branch_03122 | RAB31 interacts with multiple proteins. One specific interaction is supported by evidence from yeast two-hybrid assays, GST pull-down experiments, and co-immunoprecipitation using oligodendrocyte culture lysates. Which protein, connected to RAB31 via this specific interaction evidence, is encoded by the gene in questio... | Inositol polyphosphate 5-phosphatase OCRL | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03122","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB31 interacts with multiple proteins. One specific interaction is supported by evidence from yeast two-hybrid assays, GST pull-down experiments, an... | |
medium_divergent_branch_03123 | JUP (plakoglobin) interacts with multiple genes. One interaction is supported by evidence stating: 'However, when plakoglobin was overexpressed, it readily associated with beta-TrCP, efficiently competed with beta-catenin for binding to beta-TrCP and became polyubiquitinated.' Which disease is connected to the gene ide... | diabetic kidney disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03123","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JUP (plakoglobin) interacts with multiple genes. One interaction is supported by evidence stating: 'However, when plakoglobin was overexpressed, it r... | |
medium_divergent_branch_03125 | MYO6 interacts with multiple proteins. One specific interaction is described by the following evidence: 'we found that MVI-the interaction partner interaction takes also place in other cell lines and demonstrated that MVI cargo domain via its RRL motif binds to the interaction partner C-terminal M2 and DHR2 domains.' W... | Dedicator of cytokinesis protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03125","source_qa_id":"medium_divergent_branch_06921","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MYO6 interacts with multiple proteins. One specific interaction is described by the following evi... | |
medium_divergent_branch_03126 | GJA1 interacts with multiple genes. One of these interacting partners is reported to deubiquitinate Cx43 by directly binding to its C-terminal tyrosine residue. Which disease is associated with this specific interacting gene via a biomarker relationship? | multiple evanescent white dot syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03126","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GJA1 interacts with multiple genes. One of these interacting partners is reported to deubiquitinate Cx43 by directly binding to its C-terminal tyrosi... | |
medium_divergent_branch_03127 | DYNLT1 interacts with multiple genes. One of these interaction partners is documented to interact in vivo with the dynein light chain Tctex-1 and the heat-shock protein peptide-binding protein 74 (PBP74)/mitochondrial heat-shock protein 70 (mtHSP70)/glucose-regulated protein 75 (GRP75)/mortalin. Which disease is associ... | amyloidosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03127","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DYNLT1 interacts with multiple genes. One of these interaction partners is documented to interact in vivo with the dynein light chain Tctex-1 and the... | |
medium_divergent_branch_03128 | CDH1 interacts with multiple proteins. One interaction is supported by evidence stating: 'However, UCS15A was unable to disrupt the non-SH3-mediated protein-protein interactions of beta-catenin, with E-cadherin and alpha-catenin.' Which protein, connected to CDH1 via a binding interaction, is described in this context?... | Catenin alpha-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03128","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDH1 interacts with multiple proteins. One interaction is supported by evidence stating: 'However, UCS15A was unable to disrupt the non-SH3-mediated ... | |
medium_divergent_branch_03129 | SOX11 is involved in multiple biological processes. One such process is supported by evidence stating that Gene Chip analysis identified cell cycle regulatory pathways, including Rb-E2F, to be associated with SOX11-induced growth reduction. Which biological process is negatively regulated by this specific SOX11-associa... | lymphocyte proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03129","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX11 is involved in multiple biological processes. One such process is supported by evidence stating that Gene Chip analysis identified cell cycle r... | |
medium_divergent_branch_03132 | OGT interacts with multiple proteins. One interaction is supported by evidence stating: 'Proteomic analyses identified HCF-1, a potent transcriptional coactivator and cell cycle regulator, and O-GlcNAc transferase (OGT), the enzyme that catalyzes the addition of O-GlcNAc, as major cellular partners of this protein.' Wh... | THAP domain-containing protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03132","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OGT interacts with multiple proteins. One interaction is supported by evidence stating: 'Proteomic analyses identified HCF-1, a potent transcriptiona... | |
medium_divergent_branch_03133 | MAP2K7 interacts with multiple proteins. One interaction is supported by evidence stating: 'Both DLK and a related mitogen-activated protein kinase kinase kinase associated with, phosphorylated, and activated MKK7 in vitro.' Which disease is associated with the gene identified in this specific evidence statement? | Aarskog-Scott syndrome, X-linked | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03133","source_qa_id":"medium_divergent_branch_04094","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MAP2K7 interacts with multiple proteins. One interaction is supported by evidence stating: 'Both ... | |
medium_divergent_branch_03134 | GOLGA2 interacts with multiple proteins. One interaction is supported by evidence stating that a specific Golgi reassembly-stacking protein exists in a complex with the vesicle docking protein receptor GM130, to which it binds directly, and the membrane tethering protein p115, which also functions in the stacking of Go... | Golgi reassembly-stacking protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03134","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GOLGA2 interacts with multiple proteins. One interaction is supported by evidence stating that a specific Golgi reassembly-stacking protein exists in... | |
medium_divergent_branch_03135 | RPH3A interacts with multiple genes. One interaction is supported by evidence stating: 'By a yeast two-hybrid approach, we identified an interaction between the GUK domain of this protein and the C2B domain of rabphilin3a, a presynaptic protein involved in synaptic vesicle exocytosis.' Which disease is connected to thi... | isolated cleft palate | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03135","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPH3A interacts with multiple genes. One interaction is supported by evidence stating: 'By a yeast two-hybrid approach, we identified an interaction ... | |
medium_divergent_branch_03136 | The gene DLST interacts with multiple partners. One specific interaction involves a RING finger ubiquitin-protein isopeptide ligase that binds to and targets OGDHC-E2 for ubiquitination-dependent degradation. Which disease is associated with this specific interacting partner via a biomarker relationship? | gastric cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03136","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DLST interacts with multiple partners. One specific interaction involves a RING finger ubiquitin-protein isopeptide ligase that binds to and... | |
medium_divergent_branch_03137 | The ejaculatory duct epithelium is classified as a specific type of anatomical structure. Evidence for this classification notes that the tissue is composed of cuboidal to columnar cells, between or through which project the terminal parts of the ducts of the unicellular prostate glands. Based on this histological desc... | epithelial tube | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03137","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The ejaculatory duct epithelium is classified as a specific type of anatomical structure. Evidence for this classification notes that the tissue is c... | |
medium_divergent_branch_03138 | DLG1 interacts with multiple genes. One interaction is supported by evidence showing the in vivo association of hDlg with a voltage-gated potassium channel subfamily A member 3, expressed in T lymphocytes as an epitope-tagged protein using a vaccinia virus expression system. Which biological process is connected to thi... | potassium ion transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03138","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLG1 interacts with multiple genes. One interaction is supported by evidence showing the in vivo association of hDlg with a voltage-gated potassium c... | |
medium_divergent_branch_03139 | The protein COG7 is associated with multiple biological processes. One association is supported by evidence stating that 'All of these abnormalities were normalized in COG7-corrected patient fibroblasts.' Which biological process is a parent term (via an 'is a' relationship) of the process linked to COG7 by this specif... | protein localization to organelle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03139","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein COG7 is associated with multiple biological processes. One association is supported by evidence stating that 'All of these abnormalities ... | |
medium_divergent_branch_03140 | The gene HMG20A interacts with multiple other genes. One of these interacting partners is supported by evidence stating: 'We characterized the beta-dystrobrevin-iBRAF interaction by in vitro and in vivo association assays, localized the binding region of one protein to the other, and assessed the kinetics of the intera... | Dystrobrevin beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03140","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HMG20A interacts with multiple other genes. One of these interacting partners is supported by evidence stating: 'We characterized the beta-d... | |
medium_divergent_branch_03142 | CHEK2 interacts with multiple genes. One interaction is supported by evidence stating: 'In vitro GST-Chk2 pulldowns demonstrated that B'gamma isoforms bound to Chk2 with the strongest apparent affinity.' Which disease is associated with the gene identified by this specific evidence, via a biomarker relationship? | breast cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03142","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHEK2 interacts with multiple genes. One interaction is supported by evidence stating: 'In vitro GST-Chk2 pulldowns demonstrated that B'gamma isoform... | |
medium_divergent_branch_03143 | MEF2B interacts with multiple genes. One of these interacting partners is a corepressor; mutations in this partner have been shown to enhance the transcriptional activity of MEF2B, either by disrupting their physical interaction or by rendering MEF2B insensitive to inhibitory signaling events mediated by phosphorylatio... | NF2-related schwannomatosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03143","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MEF2B interacts with multiple genes. One of these interacting partners is a corepressor; mutations in this partner have been shown to enhance the tra... | |
medium_divergent_branch_03144 | The gene PPP2R5D interacts with multiple partners. One specific interaction is supported by evidence stating: 'The PP2A targeting-subunit B56delta specifically interacts with HAND1 and -2, but not other bHLH proteins.' Based on this evidence, which protein is encoded by the gene that interacts with PPP2R5D? | Heart- and neural crest derivatives-expressed protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03144","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PPP2R5D interacts with multiple partners. One specific interaction is supported by evidence stating: 'The PP2A targeting-subunit B56delta sp... | |
medium_divergent_branch_03145 | MLH1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we identified human MLH1, an essential component of mismatch repair (MMR), as a Poleta-interacting protein.' Which cellular component is the interacting partner located in? | nucleoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03145","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MLH1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we identified human MLH1, an essential component of mism... | |
medium_divergent_branch_03146 | MAP3K5 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we report that apoptosis signal-regulating kinase 1 (ASK1), a representative stress kinase, interacts with both GAPDH and this protein and is likely able to phosphorylate this protein at specific amino acid residue... | E3 ubiquitin-protein ligase SIAH1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03146","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K5 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we report that apoptosis signal-regulating ... | |
medium_divergent_branch_03147 | CCND1 interacts with multiple genes. One interaction is supported by evidence stating: 'In co-immunoprecipitation and pull-down assays, cyclin D1 was found to associate with the activation domain of this partner upon interleukin-6 stimulation.' Which cell type is the gene involved in this specific interaction enriched ... | neutrophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03147","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCND1 interacts with multiple genes. One interaction is supported by evidence stating: 'In co-immunoprecipitation and pull-down assays, cyclin D1 was... | |
medium_divergent_branch_03148 | GIPC1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The alpha(6) integrin and TIP-2/GIPC co-localize in retraction fibers in carcinoma cells plated on laminin, a finding suggesting a functional interaction in vivo.' Which disease is associated with the gene encoding this ... | benign prostatic hyperplasia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03148","source_qa_id":"medium_divergent_branch_05121","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GIPC1 interacts with multiple proteins. One specific interaction is supported by evidence stating... | |
medium_divergent_branch_03149 | The protein CIB1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'An enzyme-linked immunosorbent assay performed using either immobilized recombinant CIB or monoclonal antibody-captured alphaIIbbeta3 indicates a specific interaction between CIB and intact alphaIIbbeta3.' Whi... | Integrin alpha-IIb | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03149","source_qa_id":"medium_divergent_branch_01138","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein CIB1 interacts with multiple partners. One specific interaction is supported by evide... | |
medium_divergent_branch_03150 | MSH2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Previous biochemical and physical studies have shown that hMSH2 forms specific mispair binding complexes with hMSH3 and hMSH6.' Which protein, connected to MSH2 via this interaction, is encoded by the gene in question? | DNA mismatch repair protein Msh3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03150","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MSH2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Previous biochemical and physical studies have shown that h... | |
medium_divergent_branch_03151 | NAA50 interacts with multiple proteins. One interaction is supported by evidence stating: 'This verified the expression of endogenous hNAT5 protein in human cells and also identified hNAT5 as a NATH and hARD1 interacting partner.' Which protein, encoded by the gene connected to NAA50 via this specific interaction, is t... | N-alpha-acetyltransferase 10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03151","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NAA50 interacts with multiple proteins. One interaction is supported by evidence stating: 'This verified the expression of endogenous hNAT5 protein i... | |
medium_divergent_branch_03152 | NET1 interacts with multiple genes. One interaction is characterized by the finding that NET1 binds directly to the first two PDZ domains of the partner protein, and both PDZ domains are required for maximal interaction in cells. Which disease is associated with this specific interacting partner via a biomarker relatio... | Huntington disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03152","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NET1 interacts with multiple genes. One interaction is characterized by the finding that NET1 binds directly to the first two PDZ domains of the part... | |
medium_divergent_branch_03153 | BNIP3 is associated with multiple biological processes. One association is supported by evidence stating: 'We propose that BNIP3 is a gene that mediates a necrosis-like cell death through PT pore opening and mitochondrial dysfunction.' Identify the biological process that is positively regulated by the process linked t... | programmed cell death | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03153","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BNIP3 is associated with multiple biological processes. One association is supported by evidence stating: 'We propose that BNIP3 is a gene that media... | |
medium_divergent_branch_03154 | DNM1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Ash SH3 domains bind to the proline-rich region of dynamin.' Identify the disease associated with the protein described in this evidence via genomic alterations. | schizophrenia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03154","source_qa_id":"medium_divergent_branch_03687","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"DNM1 interacts with multiple proteins. One specific interaction is supported by evidence stating:... | |
medium_divergent_branch_03155 | MIR203A is associated with multiple biological processes. One association is supported by evidence that MiR-203 suppresses IL-8 mRNA and protein expression in primary human keratinocytes under both resting conditions and after TNF-α treatment. Which biological process is negatively regulated by the process linked to th... | interleukin-8 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03155","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR203A is associated with multiple biological processes. One association is supported by evidence that MiR-203 suppresses IL-8 mRNA and protein expr... | |
medium_divergent_branch_03156 | RMDN3 interacts with multiple genes. One of these interaction partners is an endoplasmic reticulum protein that forms a tether with the mitochondrial membrane protein PTPIP51. Which disease is associated with this specific interaction partner through genomic alterations? | amyotrophic lateral sclerosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03156","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RMDN3 interacts with multiple genes. One of these interaction partners is an endoplasmic reticulum protein that forms a tether with the mitochondrial... | |
medium_divergent_branch_03157 | The gene FAS interacts with multiple proteins via binding. One specific interaction involves a ligand that, upon binding to the FAS receptor (also known as CD95, a member of the tumor necrosis factor receptor family), triggers programmed cell death (apoptosis) and regulates immune responses. Which protein is encoded by... | Tumor necrosis factor ligand superfamily member 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03157","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FAS interacts with multiple proteins via binding. One specific interaction involves a ligand that, upon binding to the FAS receptor (also kn... | |
medium_divergent_branch_03158 | The biological process 'regulation of polysaccharide metabolic process' is defined as any process that modulates the frequency, rate, or extent of the chemical reactions and pathways involving polysaccharides. This process is a subtype of a broader biological process. Which broader biological process is 'regulation of ... | regulation of primary metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03158","source_qa_id":"medium_divergent_branch_05418","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of polysaccharide metabolic process' is defined as any process... | |
medium_divergent_branch_03159 | GH1 is known to interact with multiple genes. One specific interaction is characterized by the binding of Arg43 in the receptor to Asp171 of hGH. Which disease is associated with this specific receptor gene via a biomarker relationship? | autism spectrum disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03159","source_qa_id":"medium_divergent_branch_00129","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GH1 is known to interact with multiple genes. One specific interaction is characterized by the bi... | |
medium_divergent_branch_03160 | The gene BMX interacts with multiple proteins. One of these interaction partners is known to bind Etk via its SH3 and SH2 domains. Which protein is encoded by the gene that interacts with BMX in this specific manner? | RUN and FYVE domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03160","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene BMX interacts with multiple proteins. One of these interaction partners is known to bind Etk via its SH3 and SH2 domains. Which protein is e... | |
medium_divergent_branch_03161 | The entity 'respiratory system arterial endothelium' is a subtype of two distinct anatomical structures. One of these parent structures is defined as an entity that is part of the respiratory system. Which anatomical structure is the parent of 'respiratory system arterial endothelium' that satisfies this definition? | artery | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03161","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The entity 'respiratory system arterial endothelium' is a subtype of two distinct anatomical structures. One of these parent structures is defined as... | |
medium_divergent_branch_03162 | COL1A2 interacts with multiple proteins. One interaction is supported by evidence stating: 'All radiolabeled PDGF isoforms specifically interacted with type I, II, III, IV, V, and VI collagens (preferential binding to types III, I, VI, and IV) and their constituent chains, either when immobilized on polystyrene or blot... | Platelet-derived growth factor subunit B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03162","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COL1A2 interacts with multiple proteins. One interaction is supported by evidence stating: 'All radiolabeled PDGF isoforms specifically interacted wi... | |
medium_divergent_branch_03164 | BMPR1A interacts with multiple proteins. One interaction partner is described as associating directly with BMP type I (ALK2, ALK3, and ALK6) and type II (ActRII and ActRIIB) receptors, with its signaling reduced by dominant negative Smad1 and ALK3 or -6 receptors. Which protein, connected to BMPR1A through this interac... | Repulsive guidance molecule B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03164","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMPR1A interacts with multiple proteins. One interaction partner is described as associating directly with BMP type I (ALK2, ALK3, and ALK6) and type... | |
medium_divergent_branch_03166 | Olfactory receptor cells are anatomical components of two distinct higher-order structures. One of these structures is defined by the functional capacity of its constituent neurons to detect chemical stimuli involved in the sensory perception of smell. Which higher-order structure, connected to the olfactory receptor c... | chemosensory system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03166","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Olfactory receptor cells are anatomical components of two distinct higher-order structures. One of these structures is defined by the functional capa... | |
medium_divergent_branch_03167 | AKT1 interacts with multiple proteins. One interaction involves a protein that is phosphorylated by Akt at a highly conserved serine residue in its regulatory domain in vivo. Which protein is encoded by the gene corresponding to this interacting partner? | RAF proto-oncogene serine/threonine-protein kinase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03167","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKT1 interacts with multiple proteins. One interaction involves a protein that is phosphorylated by Akt at a highly conserved serine residue in its r... | |
medium_divergent_branch_03168 | The survival of motor neurons protein (SMN1) interacts with multiple Sm core proteins. One specific interaction is characterized by the fact that symmetrical dimethylation of the partner protein (along with LSm4, D1, and D3) is required for binding to the Tudor domain of SMN; inhibition of this dimethylation by S-adeno... | adenocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03168","source_qa_id":"medium_divergent_branch_06977","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The survival of motor neurons protein (SMN1) interacts with multiple Sm core proteins. One specif... | |
medium_divergent_branch_03169 | ABCC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that ATP synthase α binds to ABCC1 in plasma membranes with a ratio of 2:1.' Which protein, connected to ABCC1 via an interaction, is encoded by the gene associated with this specific binding evidence? | ATP synthase F(1) complex subunit alpha, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03169","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABCC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that ATP synthase α binds to ABCC1 in plasma memb... | |
medium_divergent_branch_03170 | GFM2 is associated with multiple biological processes. One of these associations is supported by evidence stating that EF-G2mt mediates ribosome recycling with human mitochondrial RRF but lacks translocation activity. Which biological process is a parent term (is_a) of the process linked to GFM2 by this specific eviden... | translation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03170","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GFM2 is associated with multiple biological processes. One of these associations is supported by evidence stating that EF-G2mt mediates ribosome recy... | |
medium_divergent_branch_03171 | EIF5A interacts with multiple proteins. One interaction is supported by evidence stating: 'We are able to show that eIF-5A interacts with the general nuclear export receptor, [interaction partner].' Which protein is encoded by the gene corresponding to this specific interaction partner? | Exportin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03171","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF5A interacts with multiple proteins. One interaction is supported by evidence stating: 'We are able to show that eIF-5A interacts with the general... | |
medium_divergent_branch_03172 | BMP7 interacts with multiple proteins. One interaction partner is described as a transmembrane serine/threonine kinase that binds BMP-7 in association with type I receptors such as BMPR-IA, BMPR-IB, and ActR-I. Which protein is encoded by the gene corresponding to this specific interaction partner? | Bone morphogenetic protein receptor type-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03172","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMP7 interacts with multiple proteins. One interaction partner is described as a transmembrane serine/threonine kinase that binds BMP-7 in associatio... | |
medium_divergent_branch_03173 | GSDMD is associated with multiple biological processes. One association is supported by evidence stating that cleaved GSDMD forms transmembrane pores to enable the release of IL-1 and drive cell lysis through pyroptosis. Which cell type is linked to this specific biological process via an 'enabled by cell' relationship... | CD8-alpha-positive CD11b-negative dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03173","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GSDMD is associated with multiple biological processes. One association is supported by evidence stating that cleaved GSDMD forms transmembrane pores... | |
medium_divergent_branch_03174 | CPSF6 interacts with multiple proteins. One interaction is supported by evidence stating: 'We validated one complex in detail, showing that WW domains of the [E3 ubiquitin-protein ligase] bind directly to a PPXY motif in the p68 subunit of pre-mRNA cleavage and polyadenylation factor Im in a manner that promotes p68 ub... | E3 ubiquitin-protein ligase Itchy homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03174","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CPSF6 interacts with multiple proteins. One interaction is supported by evidence stating: 'We validated one complex in detail, showing that WW domain... | |
medium_divergent_branch_03176 | HSD17B10 interacts with multiple genes. One of these interacting partners is described by evidence stating: 'Confocal and Förster resonance energy transfer (FRET) microscopy revealed that HSD17B10 recruited the interacting partner to the translocase of the outer membrane (TOM), close to PINK1, both in functional mitoch... | autosomal recessive juvenile Parkinson disease 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03176","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HSD17B10 interacts with multiple genes. One of these interacting partners is described by evidence stating: 'Confocal and Förster resonance energy tr... | |
medium_divergent_branch_03177 | VPS4A interacts with multiple proteins. One interaction partner is distinguished by evidence showing that the SKD1(E235Q) mutant associates with it on the endosomal membrane, whereas wild-type SKD1 associates with it only under conditions of cellular cholesterol depletion. Which protein is this interaction partner? | NPC intracellular cholesterol transporter 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03177","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VPS4A interacts with multiple proteins. One interaction partner is distinguished by evidence showing that the SKD1(E235Q) mutant associates with it o... | |
medium_divergent_branch_03178 | POLD1 interacts with multiple genes. One interaction is supported by evidence stating: 'Coimmunoprecipitation experiments using cell cycle synchronized cells revealed that p125 and pRb form a complex predominantly during G1 phase, the phase during which pRb is mostly unphosphorylated.' Which cell type is the gene ident... | naive B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03178","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"POLD1 interacts with multiple genes. One interaction is supported by evidence stating: 'Coimmunoprecipitation experiments using cell cycle synchroniz... | |
medium_divergent_branch_03179 | CCNE1 interacts with multiple proteins. One specific interaction is characterized by the observation that, in vitro, the interacting partner specifically binds to a cyclin E peptide containing phosphorylated-Thr380 but does not bind to a cognate nonphosphorylated peptide. Which cellular component is the interacting par... | SCF ubiquitin ligase complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03179","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCNE1 interacts with multiple proteins. One specific interaction is characterized by the observation that, in vitro, the interacting partner specific... |
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