id int64 225 5.32k | context stringlengths 2.88k 70.8k | question stringlengths 11 194 | answers dict | is_impossible bool 1
class |
|---|---|---|---|---|
1,635 | iNR-Drug: Predicting the Interaction of Drugs with Nuclear Receptors in Cellular Networking
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975431/
SHA: ee55aea26f816403476a7cb71816b8ecb1110329
Authors: Fan, Yue-Nong; Xiao, Xuan; Min, Jian-Liang; Chou, Kuo-Chen
Date: 2014-03-19
DOI: 10.3390/ijms15034915
License: cc-by... | What can nuclear receptors regulate? | {
"answer_start": [
2040
],
"text": [
"homeostasis, differentiation, embryonic development, and organ physiology"
]
} | false |
3,258 | iNR-Drug: Predicting the Interaction of Drugs with Nuclear Receptors in Cellular Networking
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975431/
SHA: ee55aea26f816403476a7cb71816b8ecb1110329
Authors: Fan, Yue-Nong; Xiao, Xuan; Min, Jian-Liang; Chou, Kuo-Chen
Date: 2014-03-19
DOI: 10.3390/ijms15034915
License: cc-by... | What are associated with cancer, diabetes, inflammatory disease, and osteoporosis? | {
"answer_start": [
332
],
"text": [
"Nuclear receptors (NRs)"
]
} | false |
3,259 | iNR-Drug: Predicting the Interaction of Drugs with Nuclear Receptors in Cellular Networking
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975431/
SHA: ee55aea26f816403476a7cb71816b8ecb1110329
Authors: Fan, Yue-Nong; Xiao, Xuan; Min, Jian-Liang; Chou, Kuo-Chen
Date: 2014-03-19
DOI: 10.3390/ijms15034915
License: cc-by... | What are nuclear receptors (NRs)? | {
"answer_start": [
1939
],
"text": [
"class of ligand-inducible transcription factors"
]
} | false |
3,260 | iNR-Drug: Predicting the Interaction of Drugs with Nuclear Receptors in Cellular Networking
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975431/
SHA: ee55aea26f816403476a7cb71816b8ecb1110329
Authors: Fan, Yue-Nong; Xiao, Xuan; Min, Jian-Liang; Chou, Kuo-Chen
Date: 2014-03-19
DOI: 10.3390/ijms15034915
License: cc-by... | What biological factors for nuclear receptors regulate? | {
"answer_start": [
2040
],
"text": [
"homeostasis, differentiation, embryonic development, and organ physiology"
]
} | false |
3,261 | iNR-Drug: Predicting the Interaction of Drugs with Nuclear Receptors in Cellular Networking
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975431/
SHA: ee55aea26f816403476a7cb71816b8ecb1110329
Authors: Fan, Yue-Nong; Xiao, Xuan; Min, Jian-Liang; Chou, Kuo-Chen
Date: 2014-03-19
DOI: 10.3390/ijms15034915
License: cc-by... | How many families are in the NR superfamily? | {
"answer_start": [
2172
],
"text": [
"seven"
]
} | false |
3,262 | iNR-Drug: Predicting the Interaction of Drugs with Nuclear Receptors in Cellular Networking
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975431/
SHA: ee55aea26f816403476a7cb71816b8ecb1110329
Authors: Fan, Yue-Nong; Xiao, Xuan; Min, Jian-Liang; Chou, Kuo-Chen
Date: 2014-03-19
DOI: 10.3390/ijms15034915
License: cc-by... | What is a prerequisite to make a molecular docking study feasible? | {
"answer_start": [
3102
],
"text": [
"a reliable 3D (three dimensional) structure of the target protein"
]
} | false |
3,263 | iNR-Drug: Predicting the Interaction of Drugs with Nuclear Receptors in Cellular Networking
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975431/
SHA: ee55aea26f816403476a7cb71816b8ecb1110329
Authors: Fan, Yue-Nong; Xiao, Xuan; Min, Jian-Liang; Chou, Kuo-Chen
Date: 2014-03-19
DOI: 10.3390/ijms15034915
License: cc-by... | What tool can be used to determine the 3D structure of proteins? | {
"answer_start": [
3208
],
"text": [
"X-ray crystallography"
]
} | false |
3,264 | iNR-Drug: Predicting the Interaction of Drugs with Nuclear Receptors in Cellular Networking
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975431/
SHA: ee55aea26f816403476a7cb71816b8ecb1110329
Authors: Fan, Yue-Nong; Xiao, Xuan; Min, Jian-Liang; Chou, Kuo-Chen
Date: 2014-03-19
DOI: 10.3390/ijms15034915
License: cc-by... | What are the shortcomings of X-ray crystallography? | {
"answer_start": [
3293
],
"text": [
"time-consuming and expensive"
]
} | false |
3,265 | iNR-Drug: Predicting the Interaction of Drugs with Nuclear Receptors in Cellular Networking
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975431/
SHA: ee55aea26f816403476a7cb71816b8ecb1110329
Authors: Fan, Yue-Nong; Xiao, Xuan; Min, Jian-Liang; Chou, Kuo-Chen
Date: 2014-03-19
DOI: 10.3390/ijms15034915
License: cc-by... | What types of proteins are difficult to crystallize? | {
"answer_start": [
3401
],
"text": [
"membrane proteins"
]
} | false |
3,266 | iNR-Drug: Predicting the Interaction of Drugs with Nuclear Receptors in Cellular Networking
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975431/
SHA: ee55aea26f816403476a7cb71816b8ecb1110329
Authors: Fan, Yue-Nong; Xiao, Xuan; Min, Jian-Liang; Chou, Kuo-Chen
Date: 2014-03-19
DOI: 10.3390/ijms15034915
License: cc-by... | Where were the data collected for this study? | {
"answer_start": [
6509
],
"text": [
"KEGG (Kyoto Encyclopedia of Genes and Genomes)"
]
} | false |
3,680 | Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521148/
SHA: ee14de143337eec0e9708f8139bfac2b7b8fdd27
Authors: Wang, Ning; Luo, Chuming; Liu, Haizhou; Yang, Xinglou; Hu, Ben; Zhang, Wei; Li, Bei; Zhu, Yan; Zhu, Guangj... | Who performed the sampling procedures? | {
"answer_start": [
2560
],
"text": [
"veterinarians"
]
} | false |
3,681 | Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521148/
SHA: ee14de143337eec0e9708f8139bfac2b7b8fdd27
Authors: Wang, Ning; Luo, Chuming; Liu, Haizhou; Yang, Xinglou; Hu, Ben; Zhang, Wei; Li, Bei; Zhu, Yan; Zhu, Guangj... | When were the fecal samples collected? | {
"answer_start": [
2855
],
"text": [
"from November 2004 to November 2014"
]
} | false |
3,682 | Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521148/
SHA: ee14de143337eec0e9708f8139bfac2b7b8fdd27
Authors: Wang, Ning; Luo, Chuming; Liu, Haizhou; Yang, Xinglou; Hu, Ben; Zhang, Wei; Li, Bei; Zhu, Yan; Zhu, Guangj... | What reference genome was used in the study? | {
"answer_start": [
4900
],
"text": [
"BatCoV HKU10"
]
} | false |
3,684 | Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521148/
SHA: ee14de143337eec0e9708f8139bfac2b7b8fdd27
Authors: Wang, Ning; Luo, Chuming; Liu, Haizhou; Yang, Xinglou; Hu, Ben; Zhang, Wei; Li, Bei; Zhu, Yan; Zhu, Guangj... | What is the length of the replicase gene ORF1ab? | {
"answer_start": [
12855
],
"text": [
"20.4 kb"
]
} | false |
3,683 | Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521148/
SHA: ee14de143337eec0e9708f8139bfac2b7b8fdd27
Authors: Wang, Ning; Luo, Chuming; Liu, Haizhou; Yang, Xinglou; Hu, Ben; Zhang, Wei; Li, Bei; Zhu, Yan; Zhu, Guangj... | What type of coronavirus was detected in R. affinis and R. sinicus species? | {
"answer_start": [
11997
],
"text": [
"BtCoV/Rh/YN2012"
]
} | false |
3,675 | Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521148/
SHA: ee14de143337eec0e9708f8139bfac2b7b8fdd27
Authors: Wang, Ning; Luo, Chuming; Liu, Haizhou; Yang, Xinglou; Hu, Ben; Zhang, Wei; Li, Bei; Zhu, Yan; Zhu, Guangj... | What is a natural reservoir of coronavirus? | {
"answer_start": [
430
],
"text": [
"Bats"
]
} | false |
3,676 | Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521148/
SHA: ee14de143337eec0e9708f8139bfac2b7b8fdd27
Authors: Wang, Ning; Luo, Chuming; Liu, Haizhou; Yang, Xinglou; Hu, Ben; Zhang, Wei; Li, Bei; Zhu, Yan; Zhu, Guangj... | What is the genome size of the coronavirus? | {
"answer_start": [
1871
],
"text": [
"26-32 kb"
]
} | false |
3,677 | Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521148/
SHA: ee14de143337eec0e9708f8139bfac2b7b8fdd27
Authors: Wang, Ning; Luo, Chuming; Liu, Haizhou; Yang, Xinglou; Hu, Ben; Zhang, Wei; Li, Bei; Zhu, Yan; Zhu, Guangj... | What is the structure of the coronavirus? | {
"answer_start": [
1786
],
"text": [
"enveloped, non-segmented, positive-strand RNA viruses"
]
} | false |
3,678 | Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521148/
SHA: ee14de143337eec0e9708f8139bfac2b7b8fdd27
Authors: Wang, Ning; Luo, Chuming; Liu, Haizhou; Yang, Xinglou; Hu, Ben; Zhang, Wei; Li, Bei; Zhu, Yan; Zhu, Guangj... | What animals do gamma and delta coronavirus mainly infect? | {
"answer_start": [
2226
],
"text": [
"birds"
]
} | false |
3,679 | Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521148/
SHA: ee14de143337eec0e9708f8139bfac2b7b8fdd27
Authors: Wang, Ning; Luo, Chuming; Liu, Haizhou; Yang, Xinglou; Hu, Ben; Zhang, Wei; Li, Bei; Zhu, Yan; Zhu, Guangj... | How many types of coronaviruses are known to cause human disease? | {
"answer_start": [
2275
],
"text": [
"Six"
]
} | false |
3,685 | Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521148/
SHA: ee14de143337eec0e9708f8139bfac2b7b8fdd27
Authors: Wang, Ning; Luo, Chuming; Liu, Haizhou; Yang, Xinglou; Hu, Ben; Zhang, Wei; Li, Bei; Zhu, Yan; Zhu, Guangj... | What plays a role in regulating the immune response to a viral infection? | {
"answer_start": [
21628
],
"text": [
"NF-κB"
]
} | false |
3,686 | Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521148/
SHA: ee14de143337eec0e9708f8139bfac2b7b8fdd27
Authors: Wang, Ning; Luo, Chuming; Liu, Haizhou; Yang, Xinglou; Hu, Ben; Zhang, Wei; Li, Bei; Zhu, Yan; Zhu, Guangj... | What is the conclusion of the coronavirus long-term surveillance studies? | {
"answer_start": [
28444
],
"text": [
"Rhinolophus bats seem to harbor a wide diversity of CoVs"
]
} | false |
4,051 | In Vitro Antiviral Activity of Circular Triple Helix Forming Oligonucleotide RNA towards Feline Infectious Peritonitis Virus Replication
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950953/
SHA: f5ad2323eb387f6e271e2842bb2cc4a33504fde3
Authors: Choong, Oi Kuan; Mehrbod, Parvaneh; Tejo, Bimo Ario; Omar, Abdul Rahman... | What is the cause of Feline Infectious Peritonitis (FIP)? | {
"answer_start": [
503
],
"text": [
"FIP virus (FIPV)"
]
} | false |
4,052 | In Vitro Antiviral Activity of Circular Triple Helix Forming Oligonucleotide RNA towards Feline Infectious Peritonitis Virus Replication
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950953/
SHA: f5ad2323eb387f6e271e2842bb2cc4a33504fde3
Authors: Choong, Oi Kuan; Mehrbod, Parvaneh; Tejo, Bimo Ario; Omar, Abdul Rahman... | What is the molecular structure of Feline Infectious Peritonitis Virus? | {
"answer_start": [
1635
],
"text": [
"enveloped virus with a nonsegmented, positive sense, single-stranded RNA genome"
]
} | false |
4,053 | In Vitro Antiviral Activity of Circular Triple Helix Forming Oligonucleotide RNA towards Feline Infectious Peritonitis Virus Replication
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950953/
SHA: f5ad2323eb387f6e271e2842bb2cc4a33504fde3
Authors: Choong, Oi Kuan; Mehrbod, Parvaneh; Tejo, Bimo Ario; Omar, Abdul Rahman... | How is FECV detected in cats? | {
"answer_start": [
2578
],
"text": [
"shedding in their faeces"
]
} | false |
4,055 | In Vitro Antiviral Activity of Circular Triple Helix Forming Oligonucleotide RNA towards Feline Infectious Peritonitis Virus Replication
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950953/
SHA: f5ad2323eb387f6e271e2842bb2cc4a33504fde3
Authors: Choong, Oi Kuan; Mehrbod, Parvaneh; Tejo, Bimo Ario; Omar, Abdul Rahman... | What type of vaccine is used to protect against FIPV infection? | {
"answer_start": [
2958
],
"text": [
"an attenuated, temperature-sensitive strain of type II FIPV"
]
} | false |
4,056 | In Vitro Antiviral Activity of Circular Triple Helix Forming Oligonucleotide RNA towards Feline Infectious Peritonitis Virus Replication
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950953/
SHA: f5ad2323eb387f6e271e2842bb2cc4a33504fde3
Authors: Choong, Oi Kuan; Mehrbod, Parvaneh; Tejo, Bimo Ario; Omar, Abdul Rahman... | Why is their controversy surrounding the FIPV vaccine? | {
"answer_start": [
3185
],
"text": [
"the vaccine contains type 2 strain, whereas type 1 viruses are more prevalent in the field"
]
} | false |
4,057 | In Vitro Antiviral Activity of Circular Triple Helix Forming Oligonucleotide RNA towards Feline Infectious Peritonitis Virus Replication
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950953/
SHA: f5ad2323eb387f6e271e2842bb2cc4a33504fde3
Authors: Choong, Oi Kuan; Mehrbod, Parvaneh; Tejo, Bimo Ario; Omar, Abdul Rahman... | For how long was the denatured polyacrylamide gel polymerized? | {
"answer_start": [
6326
],
"text": [
"30 minutes"
]
} | false |
4,058 | In Vitro Antiviral Activity of Circular Triple Helix Forming Oligonucleotide RNA towards Feline Infectious Peritonitis Virus Replication
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950953/
SHA: f5ad2323eb387f6e271e2842bb2cc4a33504fde3
Authors: Choong, Oi Kuan; Mehrbod, Parvaneh; Tejo, Bimo Ario; Omar, Abdul Rahman... | How was the binding strength measured? | {
"answer_start": [
7176
],
"text": [
"nano Isothermal Titration Calorimeter (ITC)"
]
} | false |
4,070 | Inhibitory Effect and Possible Mechanism of Action of Patchouli Alcohol against Influenza A (H2N2) Virus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264369/
SHA: f2d842780b9928cc70f38a4458553f2431877603
Authors: Wu, Huaxing; Li, Beili; Wang, Xue; Jin, Mingyuan; Wang, Guonian
Date: 2011-08-03
DOI: 10.3390/molecules... | What was the focus of this study? | {
"answer_start": [
376
],
"text": [
" the anti-influenza A (H2N2) virus activity of patchouli alcohol"
]
} | false |
4,071 | Inhibitory Effect and Possible Mechanism of Action of Patchouli Alcohol against Influenza A (H2N2) Virus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264369/
SHA: f2d842780b9928cc70f38a4458553f2431877603
Authors: Wu, Huaxing; Li, Beili; Wang, Xue; Jin, Mingyuan; Wang, Guonian
Date: 2011-08-03
DOI: 10.3390/molecules... | What do neuroaminidase inhibitors target? | {
"answer_start": [
2050
],
"text": [
"NA glycoproteins of influenza A and B virus"
]
} | false |
4,072 | Inhibitory Effect and Possible Mechanism of Action of Patchouli Alcohol against Influenza A (H2N2) Virus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264369/
SHA: f2d842780b9928cc70f38a4458553f2431877603
Authors: Wu, Huaxing; Li, Beili; Wang, Xue; Jin, Mingyuan; Wang, Guonian
Date: 2011-08-03
DOI: 10.3390/molecules... | What is the function of neuroaminidase in the influenza virus? | {
"answer_start": [
2227
],
"text": [
"cleave the α-ketosidic linkage between terminal sialic acid and an adjacent sugar residue"
]
} | false |
4,073 | Inhibitory Effect and Possible Mechanism of Action of Patchouli Alcohol against Influenza A (H2N2) Virus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264369/
SHA: f2d842780b9928cc70f38a4458553f2431877603
Authors: Wu, Huaxing; Li, Beili; Wang, Xue; Jin, Mingyuan; Wang, Guonian
Date: 2011-08-03
DOI: 10.3390/molecules... | What is Tamiflu? | {
"answer_start": [
2733
],
"text": [
"NA inhibitor"
]
} | false |
4,074 | Inhibitory Effect and Possible Mechanism of Action of Patchouli Alcohol against Influenza A (H2N2) Virus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264369/
SHA: f2d842780b9928cc70f38a4458553f2431877603
Authors: Wu, Huaxing; Li, Beili; Wang, Xue; Jin, Mingyuan; Wang, Guonian
Date: 2011-08-03
DOI: 10.3390/molecules... | What was the test for the level of cytotoxicity used in this study? | {
"answer_start": [
4844
],
"text": [
"CC 50"
]
} | false |
4,075 | Inhibitory Effect and Possible Mechanism of Action of Patchouli Alcohol against Influenza A (H2N2) Virus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264369/
SHA: f2d842780b9928cc70f38a4458553f2431877603
Authors: Wu, Huaxing; Li, Beili; Wang, Xue; Jin, Mingyuan; Wang, Guonian
Date: 2011-08-03
DOI: 10.3390/molecules... | What method was used to measure the inhibition of viral replication? | {
"answer_start": [
13705
],
"text": [
"MTT method"
]
} | false |
4,076 | Inhibitory Effect and Possible Mechanism of Action of Patchouli Alcohol against Influenza A (H2N2) Virus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264369/
SHA: f2d842780b9928cc70f38a4458553f2431877603
Authors: Wu, Huaxing; Li, Beili; Wang, Xue; Jin, Mingyuan; Wang, Guonian
Date: 2011-08-03
DOI: 10.3390/molecules... | What was the conclusion of this study? | {
"answer_start": [
18530
],
"text": [
" patchouli alcohol possesses anti-influenza A (H2N2) virus activity"
]
} | false |
4,434 | Isothermal Amplification Using a Chemical Heating Device for Point-of-Care Detection of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285652/
SHA: ef7110a9022bac2e50c995b0f6b826ff071e48f8
Authors: Curtis, Kelly A.; Rudolph, Donna L.; Nejad, Irene; Singleton, Jered; Beddoe, Andy; Weigl, Bernhard; LaBarre, Paul;... | Why have nucleic acid amplification tests been restricted to laboratory settings? | {
"answer_start": [
581
],
"text": [
"time, equipment, and technical expertise requirements"
]
} | false |
4,435 | Isothermal Amplification Using a Chemical Heating Device for Point-of-Care Detection of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285652/
SHA: ef7110a9022bac2e50c995b0f6b826ff071e48f8
Authors: Curtis, Kelly A.; Rudolph, Donna L.; Nejad, Irene; Singleton, Jered; Beddoe, Andy; Weigl, Bernhard; LaBarre, Paul;... | What screening method was evaluated in this study? | {
"answer_start": [
1334
],
"text": [
"HIV-1 RT-LAMP assay"
]
} | false |
4,436 | Isothermal Amplification Using a Chemical Heating Device for Point-of-Care Detection of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285652/
SHA: ef7110a9022bac2e50c995b0f6b826ff071e48f8
Authors: Curtis, Kelly A.; Rudolph, Donna L.; Nejad, Irene; Singleton, Jered; Beddoe, Andy; Weigl, Bernhard; LaBarre, Paul;... | What was used to measure the performance of the NINA heaters? | {
"answer_start": [
1751
],
"text": [
"whole blood specimens"
]
} | false |
4,437 | Isothermal Amplification Using a Chemical Heating Device for Point-of-Care Detection of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285652/
SHA: ef7110a9022bac2e50c995b0f6b826ff071e48f8
Authors: Curtis, Kelly A.; Rudolph, Donna L.; Nejad, Irene; Singleton, Jered; Beddoe, Andy; Weigl, Bernhard; LaBarre, Paul;... | What percentage of HIV-infected people go undetected in the United States? | {
"answer_start": [
2416
],
"text": [
"20%"
]
} | false |
4,438 | Isothermal Amplification Using a Chemical Heating Device for Point-of-Care Detection of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285652/
SHA: ef7110a9022bac2e50c995b0f6b826ff071e48f8
Authors: Curtis, Kelly A.; Rudolph, Donna L.; Nejad, Irene; Singleton, Jered; Beddoe, Andy; Weigl, Bernhard; LaBarre, Paul;... | What percentage of patients do not return for followup after HIV testing? | {
"answer_start": [
2553
],
"text": [
"35 to 50%"
]
} | false |
5,211 | Viral and bacterial co-infection in severe pneumonia triggers innate immune responses and specifically enhances IP-10: a translational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138590/
SHA: ef3d6cabc804e5eb587b34249b539c1b5efa4cc4
Authors: Hoffmann, Jonathan; Machado, Daniela; Terrier, Olivier; Pouzol, Ste... | What statistical tests were used to compare categorical variables? | {
"answer_start": [
29985
],
"text": [
"Chi-square test and Fisher's exact test"
]
} | false |
5,212 | Viral and bacterial co-infection in severe pneumonia triggers innate immune responses and specifically enhances IP-10: a translational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138590/
SHA: ef3d6cabc804e5eb587b34249b539c1b5efa4cc4
Authors: Hoffmann, Jonathan; Machado, Daniela; Terrier, Olivier; Pouzol, Ste... | What was a severe limitation of this study? | {
"answer_start": [
23550
],
"text": [
"unable to evaluate the levels of immunomodulators in the serum samples of a control group"
]
} | false |
5,213 | Viral and bacterial co-infection in severe pneumonia triggers innate immune responses and specifically enhances IP-10: a translational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138590/
SHA: ef3d6cabc804e5eb587b34249b539c1b5efa4cc4
Authors: Hoffmann, Jonathan; Machado, Daniela; Terrier, Olivier; Pouzol, Ste... | What followup is needed to confirm the results of the current study? | {
"answer_start": [
23800
],
"text": [
"a larger, longitudinal study on the etiology and severity of pneumonia"
]
} | false |
5,214 | Viral and bacterial co-infection in severe pneumonia triggers innate immune responses and specifically enhances IP-10: a translational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138590/
SHA: ef3d6cabc804e5eb587b34249b539c1b5efa4cc4
Authors: Hoffmann, Jonathan; Machado, Daniela; Terrier, Olivier; Pouzol, Ste... | What is the conclusion of this study? | {
"answer_start": [
23964
],
"text": [
"mixed respiratory infections and IP-10 may play major, interconnected roles in the pathogenesis of pneumonia"
]
} | false |
5,215 | Viral and bacterial co-infection in severe pneumonia triggers innate immune responses and specifically enhances IP-10: a translational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138590/
SHA: ef3d6cabc804e5eb587b34249b539c1b5efa4cc4
Authors: Hoffmann, Jonathan; Machado, Daniela; Terrier, Olivier; Pouzol, Ste... | What suggests that IP-10 plays a significant role on the pathogenesis of pneumonia? | {
"answer_start": [
22018
],
"text": [
"highest serum IP-10 levels"
]
} | false |
5,216 | Viral and bacterial co-infection in severe pneumonia triggers innate immune responses and specifically enhances IP-10: a translational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138590/
SHA: ef3d6cabc804e5eb587b34249b539c1b5efa4cc4
Authors: Hoffmann, Jonathan; Machado, Daniela; Terrier, Olivier; Pouzol, Ste... | What cell types help prevent pneumococcal and influenza infection in the lungs? | {
"answer_start": [
2714
],
"text": [
"airway epithelial cells 19 , resident alveolar macrophages (AMs) and blood monocytes-derived macrophages"
]
} | false |
5,226 | In Vitro Bactericidal Activity of 4- and 5-Chloro-2-hydroxy-N-[1-oxo-1-(phenylamino)alkan-2-yl]benzamides against MRSA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321674/
SHA: f0e6cef57dbae030aea2f324e21e00945ac659cf
Authors: Zadrazilova, Iveta; Pospisilova, Sarka; Pauk, Karel; Imramovsky, Ales; Vinsova, Jarmila; ... | What is the most common, clinically-relevant multiresistant pathogen in both healthcare and community acquired infections? | {
"answer_start": [
1919
],
"text": [
"Methicillin-resistant Staphylococcus aureus (MRSA)"
]
} | false |
5,227 | In Vitro Bactericidal Activity of 4- and 5-Chloro-2-hydroxy-N-[1-oxo-1-(phenylamino)alkan-2-yl]benzamides against MRSA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321674/
SHA: f0e6cef57dbae030aea2f324e21e00945ac659cf
Authors: Zadrazilova, Iveta; Pospisilova, Sarka; Pauk, Karel; Imramovsky, Ales; Vinsova, Jarmila; ... | What is the treatment of choice for MRSA infections? | {
"answer_start": [
2785
],
"text": [
"vancomycin"
]
} | false |
5,228 | In Vitro Bactericidal Activity of 4- and 5-Chloro-2-hydroxy-N-[1-oxo-1-(phenylamino)alkan-2-yl]benzamides against MRSA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321674/
SHA: f0e6cef57dbae030aea2f324e21e00945ac659cf
Authors: Zadrazilova, Iveta; Pospisilova, Sarka; Pauk, Karel; Imramovsky, Ales; Vinsova, Jarmila; ... | What enzyme is essential for the metabolism of fatty acids? | {
"answer_start": [
5196
],
"text": [
"isocitrate lyase"
]
} | false |
5,229 | In Vitro Bactericidal Activity of 4- and 5-Chloro-2-hydroxy-N-[1-oxo-1-(phenylamino)alkan-2-yl]benzamides against MRSA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321674/
SHA: f0e6cef57dbae030aea2f324e21e00945ac659cf
Authors: Zadrazilova, Iveta; Pospisilova, Sarka; Pauk, Karel; Imramovsky, Ales; Vinsova, Jarmila; ... | What was the purpose of this research? | {
"answer_start": [
6207
],
"text": [
"to assess the overall in vitro bactericidal activity of nine newly synthesized diamides"
]
} | false |
5,230 | Exploring the Innate Immunological Response of an Alternative Nonhuman Primate Model of Infectious Disease; the Common Marmoset
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129158/
SHA: f4c43e4ae49ca69dbac32620bd0a73ecbb683b91
Authors: Nelson, M.; Loveday, M.
Date: 2014-07-22
DOI: 10.1155/2014/913632
License: cc-by... | What is the conclusion of the study? | {
"answer_start": [
19511
],
"text": [
"the marmoset an appropriate animal model for biodefense-related pathogens"
]
} | false |
5,231 | Exploring the Innate Immunological Response of an Alternative Nonhuman Primate Model of Infectious Disease; the Common Marmoset
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129158/
SHA: f4c43e4ae49ca69dbac32620bd0a73ecbb683b91
Authors: Nelson, M.; Loveday, M.
Date: 2014-07-22
DOI: 10.1155/2014/913632
License: cc-by... | Why makes the marmoset an appropriate animal model for pathogen research? | {
"answer_start": [
19325
],
"text": [
"the small size of marmosets, their immune response to infection that is comparable to humans, and the ability to house more statistically relevant numbers within high containment"
]
} | false |
3,895 | Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112080/
SHA: f01ad3545245b4f884b48aa2b69c9deb942c3e77
Authors: Aldunate, Fabián; Echeverría, Natalia; Chiodi, Daniela; López, Pablo; Sánchez-Cicerón, Ad... | How can the efficacy of DAAs be diminished? | {
"answer_start": [
655
],
"text": [
"the presence of resistance-associated substitutions"
]
} | false |
3,896 | Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112080/
SHA: f01ad3545245b4f884b48aa2b69c9deb942c3e77
Authors: Aldunate, Fabián; Echeverría, Natalia; Chiodi, Daniela; López, Pablo; Sánchez-Cicerón, Ad... | Was is the response rate of the Hepatitis C virus to direct-acting antiviral treatments? | {
"answer_start": [
2043
],
"text": [
"up to 98%"
]
} | false |
3,897 | Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112080/
SHA: f01ad3545245b4f884b48aa2b69c9deb942c3e77
Authors: Aldunate, Fabián; Echeverría, Natalia; Chiodi, Daniela; López, Pablo; Sánchez-Cicerón, Ad... | How do nonnucleoside NS5B polymerase inhibitors work? | {
"answer_start": [
2755
],
"text": [
"inhibit polymerase activity by allosteric mechanisms"
]
} | false |
3,898 | Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112080/
SHA: f01ad3545245b4f884b48aa2b69c9deb942c3e77
Authors: Aldunate, Fabián; Echeverría, Natalia; Chiodi, Daniela; López, Pablo; Sánchez-Cicerón, Ad... | How many patients were studied? | {
"answer_start": [
4443
],
"text": [
"31"
]
} | false |
3,899 | Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112080/
SHA: f01ad3545245b4f884b48aa2b69c9deb942c3e77
Authors: Aldunate, Fabián; Echeverría, Natalia; Chiodi, Daniela; López, Pablo; Sánchez-Cicerón, Ad... | Was written consent obtained? | {
"answer_start": [
4871
],
"text": [
"was obtained"
]
} | false |
3,900 | Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112080/
SHA: f01ad3545245b4f884b48aa2b69c9deb942c3e77
Authors: Aldunate, Fabián; Echeverría, Natalia; Chiodi, Daniela; López, Pablo; Sánchez-Cicerón, Ad... | How much of the RNA template was in the reverse transcription reaction mixture? | {
"answer_start": [
5473
],
"text": [
"5 μl"
]
} | false |
3,901 | Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112080/
SHA: f01ad3545245b4f884b48aa2b69c9deb942c3e77
Authors: Aldunate, Fabián; Echeverría, Natalia; Chiodi, Daniela; López, Pablo; Sánchez-Cicerón, Ad... | How many RASs to NS5A inhibitors were identified? | {
"answer_start": [
11338
],
"text": [
"2 strains out of 25 (8%)"
]
} | false |
3,902 | Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112080/
SHA: f01ad3545245b4f884b48aa2b69c9deb942c3e77
Authors: Aldunate, Fabián; Echeverría, Natalia; Chiodi, Daniela; López, Pablo; Sánchez-Cicerón, Ad... | Why is the substitution E62D important in drug resistance? | {
"answer_start": [
11896
],
"text": [
"confers a higher level of resistance than the one achieved by the RAS alone"
]
} | false |
3,903 | Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112080/
SHA: f01ad3545245b4f884b48aa2b69c9deb942c3e77
Authors: Aldunate, Fabián; Echeverría, Natalia; Chiodi, Daniela; López, Pablo; Sánchez-Cicerón, Ad... | What are the key factors preventing the elimination of HCV infection in some patients? | {
"answer_start": [
14415
],
"text": [
"baseline and emergent resistance variants"
]
} | false |
5,242 | Efficient generation of recombinant RNA viruses using targeted recombination-mediated mutagenesis of bacterial artificial chromosomes containing full-length cDNA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840674/
SHA: ef38ed2f4cc96e16ce011623cc5d15d2d8ca58c3
Authors: Rasmussen, Thomas Bruun; Risager, Peter Christ... | What is needed to direct genetic mutations in RNA viruses? | {
"answer_start": [
509
],
"text": [
"Infectious cDNA clones"
]
} | false |
5,243 | Efficient generation of recombinant RNA viruses using targeted recombination-mediated mutagenesis of bacterial artificial chromosomes containing full-length cDNA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840674/
SHA: ef38ed2f4cc96e16ce011623cc5d15d2d8ca58c3
Authors: Rasmussen, Thomas Bruun; Risager, Peter Christ... | What is the structure of the pestivirus? | {
"answer_start": [
2921
],
"text": [
"single stranded positive sense RNA genomes"
]
} | false |
5,244 | Efficient generation of recombinant RNA viruses using targeted recombination-mediated mutagenesis of bacterial artificial chromosomes containing full-length cDNA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840674/
SHA: ef38ed2f4cc96e16ce011623cc5d15d2d8ca58c3
Authors: Rasmussen, Thomas Bruun; Risager, Peter Christ... | What sequences are critical for the autonomous replication of the pestivirus genome? | {
"answer_start": [
3080
],
"text": [
"5′ and 3′ untranslated regions (UTRs)"
]
} | false |
5,245 | Efficient generation of recombinant RNA viruses using targeted recombination-mediated mutagenesis of bacterial artificial chromosomes containing full-length cDNA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840674/
SHA: ef38ed2f4cc96e16ce011623cc5d15d2d8ca58c3
Authors: Rasmussen, Thomas Bruun; Risager, Peter Christ... | What are the 4 structural proteins of the pestivirus polyprotein? | {
"answer_start": [
3278
],
"text": [
"nucleocapsid protein C, envelope glycoproteins E rns , E1 and E2"
]
} | false |
5,246 | Efficient generation of recombinant RNA viruses using targeted recombination-mediated mutagenesis of bacterial artificial chromosomes containing full-length cDNA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840674/
SHA: ef38ed2f4cc96e16ce011623cc5d15d2d8ca58c3
Authors: Rasmussen, Thomas Bruun; Risager, Peter Christ... | The BAC differed from the parental cDNA sequence by what amino acid substitutions? | {
"answer_start": [
26501
],
"text": [
"aa"
]
} | false |
5,247 | Which Kind of Provider’s Operation Volumes Matters? Associations between CABG Surgical Site Infection Risk and Hospital and Surgeon Operation Volumes among Medical Centers in Taiwan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459823/
SHA: f3cbc0503581249a834895fc94cd3bae24714a0d
Authors: Yu, Tsung-Hsien; Tung, Yu-... | What is the purpose of this research study? | {
"answer_start": [
793
],
"text": [
"to examine whether a relationship exists between operation volumes and SSIs"
]
} | false |
5,248 | Which Kind of Provider’s Operation Volumes Matters? Associations between CABG Surgical Site Infection Risk and Hospital and Surgeon Operation Volumes among Medical Centers in Taiwan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459823/
SHA: f3cbc0503581249a834895fc94cd3bae24714a0d
Authors: Yu, Tsung-Hsien; Tung, Yu-... | Why are SSIs important to the overall burden on the healthcare system? | {
"answer_start": [
2903
],
"text": [
"The total length of stay and expenditure for patients with SSIs after CABG surgery is significantly longer and higher than those without SSIs"
]
} | false |
5,249 | Which Kind of Provider’s Operation Volumes Matters? Associations between CABG Surgical Site Infection Risk and Hospital and Surgeon Operation Volumes among Medical Centers in Taiwan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459823/
SHA: f3cbc0503581249a834895fc94cd3bae24714a0d
Authors: Yu, Tsung-Hsien; Tung, Yu-... | What is the "Never Event" policy? | {
"answer_start": [
3176
],
"text": [
"hospitals would no longer receive higher payments for the additional costs associated with treating patients for certain healthcare-acquired infections"
]
} | false |
5,250 | Which Kind of Provider’s Operation Volumes Matters? Associations between CABG Surgical Site Infection Risk and Hospital and Surgeon Operation Volumes among Medical Centers in Taiwan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459823/
SHA: f3cbc0503581249a834895fc94cd3bae24714a0d
Authors: Yu, Tsung-Hsien; Tung, Yu-... | Patients from how many medical centers were studied? | {
"answer_start": [
9132
],
"text": [
"19"
]
} | false |
5,251 | Which Kind of Provider’s Operation Volumes Matters? Associations between CABG Surgical Site Infection Risk and Hospital and Surgeon Operation Volumes among Medical Centers in Taiwan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459823/
SHA: f3cbc0503581249a834895fc94cd3bae24714a0d
Authors: Yu, Tsung-Hsien; Tung, Yu-... | Which patients were excluded from the study? | {
"answer_start": [
9250
],
"text": [
"CABG patients under the age of 18 years or over 85 years"
]
} | false |
5,255 | The influenza pandemic preparedness planning tool InfluSim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1832202/
SHA: f3f471d10a36a7a28e9050c10bd4dfd680cba17b
Authors: Eichner, Martin; Schwehm, Markus; Duerr, Hans-Peter; Brockmann, Stefan O
Date: 2007-03-13
DOI: 10.1186/1471-2334-7-17
License: cc-by
Abstract: BACKG... | What are the limitations of a deterministic model? | {
"answer_start": [
10476
],
"text": [
"cannot reliably represent effects originating from stochasticity, from effects in small populations, or from heterogeneities"
]
} | false |
5,266 | Genome Sequences of Porcine Epidemic Diarrhea Virus: In Vivo and In Vitro Phenotypes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056290/
SHA: f6d6d7efc1686a7d219ecfc55f9a48ce72d4fb00
Authors: Lawrence, Paulraj K.; Bumgardner, Eric; Bey, Russell F.; Stine, Douglas; Bumgarner, Roger E.
Date: 2014-06-12
DOI: 10.1128/... | How does PEDV spread? | {
"answer_start": [
1335
],
"text": [
"fecal-oral contact"
]
} | false |
5,267 | Genome Sequences of Porcine Epidemic Diarrhea Virus: In Vivo and In Vitro Phenotypes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056290/
SHA: f6d6d7efc1686a7d219ecfc55f9a48ce72d4fb00
Authors: Lawrence, Paulraj K.; Bumgardner, Eric; Bey, Russell F.; Stine, Douglas; Bumgarner, Roger E.
Date: 2014-06-12
DOI: 10.1128/... | How does PEDV cause illness? | {
"answer_start": [
1398
],
"text": [
"destroys the lining of piglets' intestines"
]
} | false |
5,268 | Genome Sequences of Porcine Epidemic Diarrhea Virus: In Vivo and In Vitro Phenotypes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056290/
SHA: f6d6d7efc1686a7d219ecfc55f9a48ce72d4fb00
Authors: Lawrence, Paulraj K.; Bumgardner, Eric; Bey, Russell F.; Stine, Douglas; Bumgarner, Roger E.
Date: 2014-06-12
DOI: 10.1128/... | What is the size of the PEDV genome? | {
"answer_start": [
1745
],
"text": [
"26 to 32 kb"
]
} | false |
5,271 | Serological Assays Based on Recombinant Viral Proteins for the Diagnosis of Arenavirus Hemorrhagic Fevers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497043/
SHA: f1d308db379b3c293bcfc8fe251c043fe8842358
Authors: Fukushi, Shuetsu; Tani, Hideki; Yoshikawa, Tomoki; Saijo, Masayuki; Morikawa, Shigeru
Date: 2012-10-12... | Which viruses are part of the Old World complex of Arenaviridae? | {
"answer_start": [
514
],
"text": [
"Lassa and Lujo viruses"
]
} | false |
5,272 | Serological Assays Based on Recombinant Viral Proteins for the Diagnosis of Arenavirus Hemorrhagic Fevers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497043/
SHA: f1d308db379b3c293bcfc8fe251c043fe8842358
Authors: Fukushi, Shuetsu; Tani, Hideki; Yoshikawa, Tomoki; Saijo, Masayuki; Morikawa, Shigeru
Date: 2012-10-12... | How can Old World and New World Arenaviruses be differentiated? | {
"answer_start": [
2565
],
"text": [
"through the use of serological assays"
]
} | false |
5,273 | Serological Assays Based on Recombinant Viral Proteins for the Diagnosis of Arenavirus Hemorrhagic Fevers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497043/
SHA: f1d308db379b3c293bcfc8fe251c043fe8842358
Authors: Fukushi, Shuetsu; Tani, Hideki; Yoshikawa, Tomoki; Saijo, Masayuki; Morikawa, Shigeru
Date: 2012-10-12... | What is the incubation period for arenavirus? | {
"answer_start": [
4195
],
"text": [
"1-3 weeks"
]
} | false |
5,274 | Serological Assays Based on Recombinant Viral Proteins for the Diagnosis of Arenavirus Hemorrhagic Fevers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497043/
SHA: f1d308db379b3c293bcfc8fe251c043fe8842358
Authors: Fukushi, Shuetsu; Tani, Hideki; Yoshikawa, Tomoki; Saijo, Masayuki; Morikawa, Shigeru
Date: 2012-10-12... | What is the structure of the Arenavirus? | {
"answer_start": [
9282
],
"text": [
"bisegmented, negative-sense, single stranded RNA genome"
]
} | false |
5,275 | Serological Assays Based on Recombinant Viral Proteins for the Diagnosis of Arenavirus Hemorrhagic Fevers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497043/
SHA: f1d308db379b3c293bcfc8fe251c043fe8842358
Authors: Fukushi, Shuetsu; Tani, Hideki; Yoshikawa, Tomoki; Saijo, Masayuki; Morikawa, Shigeru
Date: 2012-10-12... | What proteins does the Arenavirus produce? | {
"answer_start": [
9418
],
"text": [
"a glycoprotein, a nucleoprotein (NP), a matrix protein (Z), and a polymerase (L)"
]
} | false |
5,276 | Serological Assays Based on Recombinant Viral Proteins for the Diagnosis of Arenavirus Hemorrhagic Fevers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497043/
SHA: f1d308db379b3c293bcfc8fe251c043fe8842358
Authors: Fukushi, Shuetsu; Tani, Hideki; Yoshikawa, Tomoki; Saijo, Masayuki; Morikawa, Shigeru
Date: 2012-10-12... | What diagnostic test has been show to have excellent sensitivity in detecting viral infections? | {
"answer_start": [
16937
],
"text": [
"PCR assays"
]
} | false |
5,236 | Glycyrrhizin Exerts Antioxidative Effects in H5N1 Influenza A Virus-Infected Cells and Inhibits Virus Replication and Pro-Inflammatory Gene Expression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096629/
SHA: f3b7f4469ac01f1ce916d24172570c43c537627e
Authors: Michaelis, Martin; Geiler, Janina; Naczk, Patrizia; Sithi... | What is the effect of oseltamivir and zanamivir? | {
"answer_start": [
2189
],
"text": [
"neuraminidase inhibitors"
]
} | false |
5,237 | Glycyrrhizin Exerts Antioxidative Effects in H5N1 Influenza A Virus-Infected Cells and Inhibits Virus Replication and Pro-Inflammatory Gene Expression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096629/
SHA: f3b7f4469ac01f1ce916d24172570c43c537627e
Authors: Michaelis, Martin; Geiler, Janina; Naczk, Patrizia; Sithi... | What is Glycyrrhizin? | {
"answer_start": [
3358
],
"text": [
"a triterpene saponine"
]
} | false |
5,238 | Glycyrrhizin Exerts Antioxidative Effects in H5N1 Influenza A Virus-Infected Cells and Inhibits Virus Replication and Pro-Inflammatory Gene Expression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096629/
SHA: f3b7f4469ac01f1ce916d24172570c43c537627e
Authors: Michaelis, Martin; Geiler, Janina; Naczk, Patrizia; Sithi... | What is the effect of Glycyrrhizin in viral infections? | {
"answer_start": [
3437
],
"text": [
"interfere with replication and/or cytopathogenic effect (CPE) induction of many viruses"
]
} | false |
5,239 | Glycyrrhizin Exerts Antioxidative Effects in H5N1 Influenza A Virus-Infected Cells and Inhibits Virus Replication and Pro-Inflammatory Gene Expression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096629/
SHA: f3b7f4469ac01f1ce916d24172570c43c537627e
Authors: Michaelis, Martin; Geiler, Janina; Naczk, Patrizia; Sithi... | What is another word for hypercytokinaemia? | {
"answer_start": [
3853
],
"text": [
"cytokine storm'"
]
} | false |
5,240 | Glycyrrhizin Exerts Antioxidative Effects in H5N1 Influenza A Virus-Infected Cells and Inhibits Virus Replication and Pro-Inflammatory Gene Expression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096629/
SHA: f3b7f4469ac01f1ce916d24172570c43c537627e
Authors: Michaelis, Martin; Geiler, Janina; Naczk, Patrizia; Sithi... | What has been correlated with the pathogenicity of the H5N1 infection? | {
"answer_start": [
15524
],
"text": [
"caspase-dependent apoptosis in airway cells"
]
} | false |
5,241 | Glycyrrhizin Exerts Antioxidative Effects in H5N1 Influenza A Virus-Infected Cells and Inhibits Virus Replication and Pro-Inflammatory Gene Expression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096629/
SHA: f3b7f4469ac01f1ce916d24172570c43c537627e
Authors: Michaelis, Martin; Geiler, Janina; Naczk, Patrizia; Sithi... | What is the conclusion of the study? | {
"answer_start": [
18948
],
"text": [
"glycyrrhizin might also serve as lead structure for the development of novel anti-influenza drugs"
]
} | false |
3,240 | Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243941/
SHA: f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0
Authors: Sun, Bing; He, Hangyong; Wang, Zheng; Qu, Jiuxin; Li, Xuya... | What is the mean duration of time from single lobe consolidation to bilateral multilobar lung infiltrates in human adenovirus type 55 (HAdV-55)? | {
"answer_start": [
1760
],
"text": [
"2 days"
]
} | false |
3,241 | Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243941/
SHA: f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0
Authors: Sun, Bing; He, Hangyong; Wang, Zheng; Qu, Jiuxin; Li, Xuya... | What is the mean duration of time from first positive chest x-ray to bilateral multilobar lung infiltrates in human adenovirus type 55 (HAdV-55)? | {
"answer_start": [
1771
],
"text": [
"4.8 days"
]
} | false |
3,242 | Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243941/
SHA: f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0
Authors: Sun, Bing; He, Hangyong; Wang, Zheng; Qu, Jiuxin; Li, Xuya... | What are the most frequent clinical manifestations of human adenovirus type 55 (HAdV-55) induced ARDS? | {
"answer_start": [
2285
],
"text": [
"Persistent high fever, dyspnea and rapid progression to respiratory failure within 2 weeks, together with bilateral consolidations and infiltrates"
]
} | false |
3,243 | Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243941/
SHA: f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0
Authors: Sun, Bing; He, Hangyong; Wang, Zheng; Qu, Jiuxin; Li, Xuya... | What do we know about the genomics of human adenovirus type 55 (HAdV-55)? | {
"answer_start": [
3601
],
"text": [
"This pathogen was fully characterized by whole-genome sequencing"
]
} | false |
3,244 | Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243941/
SHA: f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0
Authors: Sun, Bing; He, Hangyong; Wang, Zheng; Qu, Jiuxin; Li, Xuya... | What are the clinical symptoms of human adenovirus type 55 (HAdV-55)? | {
"answer_start": [
8509
],
"text": [
"Flulike symptoms, such as fever, cough and little sputum, were commonly observed at the onset of illness"
]
} | false |
3,245 | Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243941/
SHA: f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0
Authors: Sun, Bing; He, Hangyong; Wang, Zheng; Qu, Jiuxin; Li, Xuya... | What is the mean time from onset of symptoms to dyspnea in human adenovirus type 55 (HAdV-55)? | {
"answer_start": [
8958
],
"text": [
"5 days"
]
} | false |
3,246 | Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243941/
SHA: f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0
Authors: Sun, Bing; He, Hangyong; Wang, Zheng; Qu, Jiuxin; Li, Xuya... | What is the mean time of onset of symptoms to ICU admission in human adenovirus type 55 (HAdV-55)? | {
"answer_start": [
9127
],
"text": [
"9.6 days"
]
} | false |
3,247 | Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243941/
SHA: f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0
Authors: Sun, Bing; He, Hangyong; Wang, Zheng; Qu, Jiuxin; Li, Xuya... | What is the mean rate of respiration upon admission to the ICU when admitted for human adenovirus type 55 (HAdV-55)? | {
"answer_start": [
9244
],
"text": [
"43 breaths per minute"
]
} | false |
3,248 | Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243941/
SHA: f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0
Authors: Sun, Bing; He, Hangyong; Wang, Zheng; Qu, Jiuxin; Li, Xuya... | What is the white blood cell count in severe cases of human adenovirus type 55 (HAdV-55)? | {
"answer_start": [
9441
],
"text": [
" low or in the normal range"
]
} | false |
3,249 | Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243941/
SHA: f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0
Authors: Sun, Bing; He, Hangyong; Wang, Zheng; Qu, Jiuxin; Li, Xuya... | What does a chest x-ray look like for a patient with a severe case of human adenovirus type 55 (HAdV-55)? | {
"answer_start": [
9825
],
"text": [
"CXRs revealed multiple bilateral lobar or segment consolidation in the lungs of all five patients, and radiographic lesions progressed rapidly after ICU admission"
]
} | false |
3,250 | Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243941/
SHA: f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0
Authors: Sun, Bing; He, Hangyong; Wang, Zheng; Qu, Jiuxin; Li, Xuya... | What are the high resolution pulmonary CT scan findings for patients with severe cases of human adenovirus type 55 (HAdV-55)? | {
"answer_start": [
10189
],
"text": [
"Consolidations within a single lobe or several lobes with a clear border and air bronchogram were the most common findings on HRCT scans. Nodules, patches, pleural effusion, abscess and a cavity were also seen visualized by HRCT"
]
} | false |
3,251 | Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243941/
SHA: f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0
Authors: Sun, Bing; He, Hangyong; Wang, Zheng; Qu, Jiuxin; Li, Xuya... | Where could a clinician acquire a positive viral sample in severe cases of human adenovirus type 55 (HAdV-55)? | {
"answer_start": [
10659
],
"text": [
"All patients had HAdV-55 viremia. In four of the five patients, it was first detected in endotracheal aspirate (ETA) samples"
]
} | false |
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