go_id string | go_numeric_id int64 | name string | namespace string | definition string | definition_xrefs list | comment string | synonyms list | synonym_scopes list | alt_ids list | subsets list | xrefs list | is_a_ids list | relationship_edges list | relationship_types list | relationship_target_ids list | parent_ids list | intersection_of list | union_of list | disjoint_from list | replaced_by list | consider list | property_values list | created_by string | creation_date string | is_obsolete bool | in_go_basic bool | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GO:0004081 | 4,081 | bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity | molecular_function | Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate. | [
"EC:3.6.1.17",
"PMID:4955726"
] | null | [
"1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity",
"Ap(4)A hydrolase activity",
"Ap(4)Aase activity",
"Ap4A hydrolase activity",
"Ap4Aase activity",
"bis(5'-adenosyl)-tetraphosphatase activity",
"bis(5'-guanosyl)-tetraphosphatase activity",
"diadenosine 5',5'''-P(1),P(4)-tetrapho... | [
"RELATED",
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.6.1.17",
"MetaCyc:3.6.1.17-RXN",
"Reactome:R-HSA-5696197 \"NUDT2 hydrolyses GP4G to GTP, GMP\"",
"RHEA:22484"
] | [
"GO:0008796"
] | [] | [] | [] | [
"GO:0008796"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.6.1.17",
"skos:exactMatch RHEA:22484",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004082 | 4,082 | bisphosphoglycerate mutase activity | molecular_function | Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate. | [
"EC:5.4.2.4"
] | null | [
"2,3-bisphosphoglycerate mutase activity",
"2,3-bisphosphoglycerate synthase activity",
"2,3-diphosphoglycerate mutase activity",
"2,3-diphosphoglycerate synthase activity",
"2,3-diphosphoglyceromutase activity",
"3-phospho-D-glycerate 1,2-phosphomutase activity",
"biphosphoglycerate synthase activity",... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:5.4.2.4",
"MetaCyc:BISPHOSPHOGLYCERATE-MUTASE-RXN",
"Reactome:R-HSA-6798335 \"BPGM dimer isomerises 1,3BPG to 2,3BPG\"",
"RHEA:17765"
] | [
"GO:0016868"
] | [] | [] | [] | [
"GO:0016868"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.4.2.4",
"skos:exactMatch RHEA:17765",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004083 | 4,083 | obsolete bisphosphoglycerate 2-phosphatase activity | molecular_function | OBSOLETE. Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H2O = 3-phospho-D-glycerate + phosphate. | [
"PMID:8567632",
"PMID:9452443"
] | This term was deprecated because there is no evidence that this reaction exists. | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24905\" xsd:anyURI"
] | null | null | true | true | 1 |
GO:0004084 | 4,084 | branched-chain-amino-acid:2-oxoglutarate transaminase activity | molecular_function | Catalysis of the reaction: a branched-chain amino acid (L-leucine, L-isoleucine and L-valine) + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. | [
"EC:2.6.1.42"
] | null | [
"branched-chain amino acid aminotransferase activity",
"branched-chain amino acid-glutamate transaminase activity",
"branched-chain aminotransferase activity",
"branched-chain-amino-acid transaminase activity",
"branched-chain-amino-acid:2-oxoglutarate aminotransferase activity",
"glutamate-branched-chain... | [
"EXACT",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.6.1.42",
"Reactome:R-HSA-508179 \"a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2]\"",
"Reactome:R-HSA-508189 \"a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketogluta... | [
"GO:0140385"
] | [] | [] | [] | [
"GO:0140385"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.6.1.42",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28070\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31140\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004085 | 4,085 | obsolete butyryl-CoA dehydrogenase activity | molecular_function | OBSOLETE. Catalysis of the reaction: butanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]. | [
"GOC:curators"
] | This term was obsoleted because it represents a specific substrate of short-chain fatty acyl-CoA dehydrogenase activity; GO:0016937. | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0016937"
] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23497\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25073\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26437\" xsd:anyURI"
] | null | null | true | true | 8 |
GO:0004086 | 4,086 | obsolete carbamoyl-phosphate synthase activity | molecular_function | OBSOLETE. Catalysis of a reaction that results in the formation of carbamoyl phosphate. | [
"GOC:mah"
] | This term was made obsolete because it is a grouping term based on name, rather than on function. | [
"carbamoyl phosphate synthase activity",
"carbamoyl-phosphate synthase activity"
] | [
"EXACT",
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004087",
"GO:0004088"
] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28243\" xsd:anyURI"
] | null | null | true | true | 2 |
GO:0004087 | 4,087 | carbamoyl-phosphate synthase (ammonia) activity | molecular_function | Catalysis of the reaction: 2 ATP + hydrogencarbonate + NH4+ = 2 ADP + carbamoyl phosphate + 2 H+ + phosphate. | [
"EC:6.3.4.16",
"RHEA:18029"
] | null | [
"carbamoyl phosphate synthase (ammonia) activity",
"carbamoyl-phosphate synthetase (ammonia) activity",
"carbamoyl-phosphate synthetase I activity",
"carbamoylphosphate synthase (ammonia)",
"carbamoylphosphate synthase activity",
"carbamoylphosphate synthetase (ammonia) activity",
"carbamylphosphate syn... | [
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW"
] | [] | [] | [
"EC:6.3.4.16",
"KEGG_REACTION:R00149",
"MetaCyc:RXN-13202",
"Reactome:R-HSA-70555 \"2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]\"",
"Reactome:R-HSA-9955543 \"CPS1 variants don't synthesize carbamoyl phosphate\"",
"RHEA:18029"
] | [
"GO:0016879"
] | [] | [] | [] | [
"GO:0016879"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.4.16",
"skos:exactMatch RHEA:18029",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24338\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004088 | 4,088 | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | molecular_function | Catalysis of the reaction: hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H+. | [
"RHEA:18633"
] | null | [
"carbamoyl phosphate synthase (glutamine-hydrolyzing) activity",
"carbamoyl phosphate synthetase activity",
"carbamoyl-phosphate synthase (glutamine-hydrolysing) activity",
"carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity",
"carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity",
... | [
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.3.5.5",
"MetaCyc:CARBPSYN-RXN",
"Reactome:R-HSA-73577 \"CAD hexamer transforms L-Gln to CAP\"",
"RHEA:18633"
] | [
"GO:0016884"
] | [] | [] | [] | [
"GO:0016884"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.5.5",
"skos:exactMatch RHEA:18633",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30008\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004089 | 4,089 | carbonate dehydratase activity | molecular_function | Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. | [
"EC:4.2.1.1"
] | null | [
"anhydrase activity",
"carbonate anhydrase activity",
"carbonate hydro-lyase (carbon-dioxide-forming)",
"carbonate hydro-lyase activity",
"carbonic acid anhydrase activity",
"carbonic anhydrase A",
"carbonic anhydrase activity",
"carbonic dehydratase activity",
"carboxyanhydrase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.2.1.1",
"MetaCyc:RXN0-5224",
"Reactome:R-HSA-1237045 \"Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton\"",
"Reactome:R-HSA-1237047 \"CA4:Zn2+ hydrates CO2 to HCO3-\"",
"Reactome:R-HSA-1237059 \"CA4:Zn2+ dehydrates HCO3- to CO2\"",
"Reactome:R-HSA-1237081 \"Carbonic anhydras... | [
"GO:0016836"
] | [] | [] | [] | [
"GO:0016836"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.2.1.1",
"skos:exactMatch RHEA:10748",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25985\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004090 | 4,090 | carbonyl reductase (NADPH) activity | molecular_function | Catalysis of the reaction: a secondary alcohol + NADP+ = a ketone + H+ + NADPH. | [
"RHEA:19257"
] | null | [
"aldehyde reductase 1",
"aldehyde reductase I activity",
"ALR3",
"carbonyl reductase activity",
"NADPH-dependent carbonyl reductase activity",
"NADPH2-dependent carbonyl reductase activity",
"nonspecific NADPH-dependent carbonyl reductase activity",
"prostaglandin 9-ketoreductase activity",
"seconda... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"NARROW"
] | [] | [] | [
"EC:1.1.1.184",
"MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN",
"Reactome:R-HSA-8937419 \"CBR3 reduces DOX to DOXOL\"",
"RHEA:10724",
"RHEA:12212",
"RHEA:13829",
"RHEA:16321",
"RHEA:16817",
"RHEA:18941",
"RHEA:19257",
"RHEA:25960",
"RHEA:31891",
"RHEA:32339",
"RHEA:32619",
"RHEA:35607",
"RHEA:... | [
"GO:0008106"
] | [] | [] | [] | [
"GO:0008106"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.184",
"skos:exactMatch MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN",
"skos:exactMatch RHEA:19257",
"skos:narrowMatch RHEA:10724",
"skos:narrowMatch RHEA:12212",
"skos:narrowMatch RHEA:13829",
"skos:narrowMatch RHEA:16321",
"skos:narrowMatch RHEA:16817",
"skos:narrowMatch RHEA:1894... | null | null | false | true | 1 |
GO:0004092 | 4,092 | carnitine O-acetyltransferase activity | molecular_function | Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA. | [
"EC:2.3.1.7",
"RHEA:21136"
] | null | [
"acetyl-CoA-carnitine O-acetyltransferase activity",
"acetyl-CoA:carnitine O-acetyltransferase activity",
"acetylcarnitine transferase activity",
"carnitine acetyl coenzyme A transferase activity",
"carnitine acetylase activity",
"carnitine acetyltransferase activity",
"carnitine O-acetyltransferase I a... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"RELATED",
"RELATED"
] | [
"GO:0004093",
"GO:0004094"
] | [] | [
"EC:2.3.1.7",
"KEGG_REACTION:R02396",
"MetaCyc:CARNITINE-O-ACETYLTRANSFERASE-RXN",
"Reactome:R-HSA-390284 \"propionyl-CoA + carnitine => propionylcarnitine + CoASH\"",
"Reactome:R-HSA-390291 \"acetyl-CoA + carnitine => acetylcarnitine + CoASH\"",
"RHEA:21136"
] | [
"GO:0016406",
"GO:0016413"
] | [] | [] | [] | [
"GO:0016406",
"GO:0016413"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.7",
"skos:exactMatch RHEA:21136",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004095 | 4,095 | carnitine O-palmitoyltransferase activity | molecular_function | Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. | [
"EC:2.3.1.21"
] | null | [
"acylcarnitine transferase activity",
"carnitine palmitoyltransferase activity",
"carnitine palmitoyltransferase I",
"carnitine palmitoyltransferase II",
"carnitine palmitoyltransferase-A",
"CPT",
"CPT I (outer membrane carnitine palmitoyl transferase)",
"CPT-A",
"CPT-B",
"CPTi",
"CPTo",
"L-ca... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.3.1.21",
"MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN",
"Reactome:R-HSA-200406 \"CPT1A transfers PALM to CAR\"",
"Reactome:R-HSA-9911362 \"CPT1B transfers PALM to CAR\"",
"RHEA:12661"
] | [
"GO:0016406",
"GO:0016416"
] | [] | [] | [] | [
"GO:0016406",
"GO:0016416"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.21",
"skos:exactMatch RHEA:12661",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004096 | 4,096 | catalase activity | molecular_function | Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. | [
"EC:1.11.1.6"
] | null | [
"bacterial catalase-peroxidase activity",
"caperase activity",
"CAT",
"catalase reaction",
"catalase-peroxidase activity",
"equilase activity",
"haem catalase activity",
"heme catalase activity",
"hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity",
"manganese catalase activity",
"optid... | [
"NARROW",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"RELATED",
"NARROW",
"RELATED"
] | [
"GO:0016952",
"GO:0016953"
] | [] | [
"EC:1.11.1.6",
"MetaCyc:CATAL-RXN",
"Reactome:R-HSA-1222704 \"KatG reduces H2O2\"",
"Reactome:R-HSA-76031 \"2 H2O2 => O2 + 2 H2O\"",
"RHEA:20309",
"UM-BBD_enzymeID:r1335"
] | [
"GO:0004601"
] | [] | [] | [] | [
"GO:0004601"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.11.1.6",
"skos:exactMatch RHEA:20309",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004097 | 4,097 | catechol oxidase activity | molecular_function | Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O. This reaction catalyzes exclusively the oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones. | [
"EC:1.10.3.1",
"PMID:22120533"
] | GO:0004097 describes oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones. For monooxygenation of monophenols, consider instead the term 'monophenol monooxygenase activity ; GO:0004503'. | [
"catecholase",
"diphenol oxidase activity",
"dopamine monooxygenase activity",
"L-DOPA monooxygenase activity",
"L-dopa oxidase activity",
"o-diphenol oxidoreductase",
"o-diphenolase activity",
"phenolase activity",
"polyphenol oxidase activity",
"pyrocatechol oxidase",
"tyrosinase activity"
] | [
"EXACT",
"EXACT",
"NARROW",
"NARROW",
"NARROW",
"EXACT",
"EXACT",
"BROAD",
"RELATED",
"BROAD",
"BROAD"
] | [
"GO:0036263",
"GO:0036264",
"GO:0102316"
] | [] | [
"EC:1.10.3.1",
"MetaCyc:CATECHOL-OXIDASE-RXN",
"MetaCyc:RXN-13061",
"Reactome:R-HSA-5662662 \"Tyrosinase oxidises tyrosine to dopaquinone\"",
"Reactome:R-HSA-5662692 \"Dopa is oxidized to dopaquinone by TYR\"",
"Reactome:R-HSA-5663050 \"DHI and DHICA polymerize forming eumelanin\"",
"Reactome:R-HSA-8878... | [
"GO:0004497",
"GO:0016682"
] | [] | [] | [] | [
"GO:0004497",
"GO:0016682"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.10.3.1",
"skos:exactMatch RHEA:21632",
"skos:narrowMatch MetaCyc:RXN-13061",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21024\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25794\" xsd:anyURI",
"term_tracker_item \"... | null | null | false | true | 8 |
GO:0004098 | 4,098 | cerebroside-sulfatase activity | molecular_function | Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate. | [
"EC:3.1.6.8"
] | null | [
"arylsulfatase A activity",
"cerebroside sulfate sulfatase activity",
"cerebroside-3-sulfate 3-sulfohydrolase activity",
"cerebroside-sulphatase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:3.1.6.8",
"MetaCyc:CEREBROSIDE-SULFATASE-RXN",
"Reactome:R-HSA-1606807 \"ARSA removes sulfate from PSAP(195-273):Sulfatide\"",
"Reactome:R-HSA-9840949 \"ARSA removes sulfate from SM3\"",
"RHEA:21300"
] | [
"GO:0008484"
] | [] | [] | [] | [
"GO:0008484"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.6.8",
"skos:exactMatch RHEA:21300",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004099 | 4,099 | chitin deacetylase activity | molecular_function | Catalysis of the reaction: chitin + H2O = chitosan + acetate. | [
"EC:3.5.1.41"
] | null | [
"chitin amidohydrolase activity"
] | [
"RELATED"
] | [] | [] | [
"EC:3.5.1.41",
"MetaCyc:CHITIN-DEACETYLASE-RXN",
"RHEA:10464"
] | [
"GO:0016811",
"GO:0019213"
] | [] | [] | [] | [
"GO:0016811",
"GO:0019213"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.1.41",
"skos:exactMatch RHEA:10464",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004100 | 4,100 | chitin synthase activity | molecular_function | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1). | [
"EC:2.4.1.16"
] | null | [
"chitin synthetase activity",
"chitin-UDP acetyl-glucosaminyl transferase activity",
"chitin-UDP N-acetylglucosaminyltransferase activity",
"chitin-uridine diphosphate acetylglucosaminyltransferase activity",
"trans-N-acetylglucosaminosylase activity",
"UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglu... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.1.16",
"MetaCyc:CHITIN-SYNTHASE-RXN",
"RHEA:16637"
] | [
"GO:0008375"
] | [] | [] | [] | [
"GO:0008375"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.16",
"skos:exactMatch RHEA:16637",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004102 | 4,102 | choline O-acetyltransferase activity | molecular_function | Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA. | [
"EC:2.3.1.6",
"RHEA:18821"
] | null | [
"acetyl-CoA:choline O-acetyltransferase activity",
"CHOACTase activity",
"choline acetylase activity",
"choline acetyltransferase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.3.1.6",
"KEGG_REACTION:R01023",
"MetaCyc:CHOLINE-O-ACETYLTRANSFERASE-RXN",
"Reactome:R-HSA-264622 \"Cho is acetylated to AcCho by CHAT\"",
"RHEA:18821"
] | [
"GO:0016413"
] | [] | [] | [] | [
"GO:0016413"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.6",
"skos:exactMatch RHEA:18821",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004103 | 4,103 | choline kinase activity | molecular_function | Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H+. | [
"EC:2.7.1.32",
"RHEA:12837"
] | null | [
"ATP:choline phosphotransferase activity",
"choline kinase (phosphorylating)",
"choline phosphokinase activity",
"choline-ethanolamine kinase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.32",
"KEGG_REACTION:R01021",
"MetaCyc:CHOLINE-KINASE-RXN",
"Reactome:R-HSA-1483004 \"Cho is phosphorylated to PCho by CHK dimer\"",
"RHEA:12837"
] | [
"GO:0016301",
"GO:0016773"
] | [
"part_of GO:0006657"
] | [
"part_of"
] | [
"GO:0006657"
] | [
"GO:0006657",
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.32",
"skos:exactMatch RHEA:12837",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004104 | 4,104 | cholinesterase activity | molecular_function | Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion. | [
"EC:3.1.1.8"
] | null | [
"acylcholine acylhydrolase activity",
"anticholineesterase activity",
"benzoylcholinesterase activity",
"BtChoEase activity",
"butyrylcholine esterase activity",
"butyrylcholinesterase activity",
"choline esterase activity",
"choline esterase II (unspecific) activity",
"non-specific cholinesterase a... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [
"goslim_chembl"
] | [
"EC:3.1.1.8",
"MetaCyc:CHOLINESTERASE-RXN",
"RHEA:21964"
] | [
"GO:0052689"
] | [] | [] | [] | [
"GO:0052689"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.1.8",
"skos:exactMatch RHEA:21964",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004105 | 4,105 | choline-phosphate cytidylyltransferase activity | molecular_function | Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline. | [
"EC:2.7.7.15"
] | null | [
"CDP-choline pyrophosphorylase activity",
"CDP-choline synthetase activity",
"choline phosphate cytidylyltransferase activity",
"CTP-phosphocholine cytidylyltransferase activity",
"CTP:choline-phosphate cytidylyltransferase activity",
"CTP:phosphocholine cytidylyltransferase activity",
"CTP:phosphorylch... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.7.15",
"MetaCyc:2.7.7.15-RXN",
"Reactome:R-HSA-1483081 \"PCho and CTP are condensed to CDP-Cho by PCYT1 dimer\"",
"RHEA:18997"
] | [
"GO:0070567"
] | [
"part_of GO:0006657"
] | [
"part_of"
] | [
"GO:0006657"
] | [
"GO:0006657",
"GO:0070567"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.7.15",
"skos:exactMatch RHEA:18997",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004106 | 4,106 | chorismate mutase activity | molecular_function | Catalysis of the reaction: chorismate = prephenate. | [
"EC:5.4.99.5",
"RHEA:13897"
] | null | [
"chorismate pyruvatemutase activity",
"hydroxyphenylpyruvate synthase activity"
] | [
"RELATED",
"BROAD"
] | [] | [] | [
"EC:5.4.99.5",
"KEGG_REACTION:R01715",
"MetaCyc:CHORISMATEMUT-RXN",
"RHEA:13897"
] | [
"GO:0016866"
] | [] | [] | [] | [
"GO:0016866"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.4.99.5",
"skos:exactMatch RHEA:13897",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004107 | 4,107 | chorismate synthase activity | molecular_function | Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. | [
"EC:4.2.3.5",
"RHEA:21020"
] | null | [
"5-enolpyruvylshikimate-3-phosphate phospholyase activity",
"5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)",
"5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.2.3.5",
"KEGG_REACTION:R01714",
"MetaCyc:CHORISMATE-SYNTHASE-RXN",
"RHEA:21020"
] | [
"GO:0016838"
] | [] | [] | [] | [
"GO:0016838"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.2.3.5",
"skos:exactMatch RHEA:21020",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004108 | 4,108 | obsolete citrate (Si)-synthase activity | molecular_function | OBSOLETE. Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group. | [
"EC:2.3.3.1"
] | null | [
"(R)-citric synthase activity",
"acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]",
"citrate condensing enzyme activity",
"citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity",
"citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)"... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED"
] | [] | [] | [
"Reactome:R-HSA-70975 \"CS acetylates OA to citrate\""
] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0036440"
] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28183\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29891\" xsd:anyURI"
] | null | null | true | true | 3 |
GO:0004109 | 4,109 | coproporphyrinogen oxidase activity | molecular_function | Catalysis of the reaction: coproporphyrinogen III + 2 H+ + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX. | [
"EC:1.3.3.3",
"RHEA:18257"
] | null | [
"coprogen oxidase activity",
"coproporphyrinogen-III oxidase activity",
"coproporphyrinogen:oxygen oxidoreductase (decarboxylating)",
"coproporphyrinogenase activity"
] | [
"EXACT",
"EXACT",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:1.3.3.3",
"KEGG_REACTION:R03220",
"MetaCyc:RXN0-1461",
"Reactome:R-HSA-189421 \"CPO transforms COPRO3 to PPGEN9\"",
"RHEA:18257"
] | [
"GO:0016634"
] | [] | [] | [] | [
"GO:0016634"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.3.3.3",
"skos:exactMatch RHEA:18257",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004110 | 4,110 | corticosteroid side-chain-isomerase activity | molecular_function | Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al. | [
"EC:5.3.1.21",
"RHEA:17861"
] | null | [
"11-deoxycorticosterone aldose-ketose-isomerase activity",
"11-deoxycorticosterone ketol-isomerase activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:5.3.1.21",
"KEGG_REACTION:R04165",
"MetaCyc:CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN",
"RHEA:17861"
] | [
"GO:0016861"
] | [] | [] | [] | [
"GO:0016861"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.3.1.21",
"skos:exactMatch RHEA:17861",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004111 | 4,111 | creatine kinase activity | molecular_function | Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H+. | [
"EC:2.7.3.2",
"RHEA:17157"
] | null | [
"adenosine triphosphate-creatine transphosphorylase activity",
"ATP:creatine N-phosphotransferase activity",
"ATP:creatine phosphotransferase activity",
"BB-CK",
"CK",
"CK-BB",
"CK-MB",
"CK-MM",
"CKMiMi",
"creatine phosphokinase activity",
"creatine phosphotransferase activity",
"MB-CK",
"Mi... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.3.2",
"KEGG_REACTION:R01881",
"MetaCyc:CREATINE-KINASE-RXN",
"Reactome:R-HSA-200318 \"creatine + ATP => phosphocreatine + ADP [CKB,CKM]\"",
"Reactome:R-HSA-200326 \"creatine + ATP => phosphocreatine + ADP [CK octamer]\"",
"RHEA:17157"
] | [
"GO:0016301",
"GO:0016775"
] | [] | [] | [] | [
"GO:0016301",
"GO:0016775"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.3.2",
"skos:exactMatch RHEA:17157",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28523\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontolo... | null | null | false | true | 7 |
GO:0004112 | 4,112 | cyclic-nucleotide phosphodiesterase activity | molecular_function | Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. | [
"GOC:mah"
] | null | [] | [] | [] | [] | [] | [
"GO:0008081"
] | [] | [] | [] | [
"GO:0008081"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 6 |
GO:0004113 | 4,113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity | molecular_function | Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate. | [
"EC:3.1.4.37"
] | null | [
"2',3'-cyclic AMP phosphodiesterase activity",
"2',3'-cyclic nucleoside monophosphate phosphodiesterase",
"2',3'-cyclic nucleotide 3'-phosphodiesterase activity",
"2',3'-cyclic nucleotide 3'-phosphohydrolase activity",
"2',3'-cyclic nucleotide phosphohydrolase",
"2':3'-CNMP-3'-ase activity",
"2':3'-cycl... | [
"RELATED",
"BROAD",
"EXACT",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"NARROW",
"RELATED"
] | [] | [] | [
"EC:3.1.4.37",
"MetaCyc:3.1.4.37-RXN",
"RHEA:14489",
"RHEA:37191",
"RHEA:37211",
"RHEA:37239",
"RHEA:41956"
] | [
"GO:0004112"
] | [] | [] | [] | [
"GO:0004112"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.4.37",
"skos:exactMatch RHEA:14489",
"skos:narrowMatch RHEA:37191",
"skos:narrowMatch RHEA:37211",
"skos:narrowMatch RHEA:37239",
"skos:narrowMatch RHEA:41956",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004114 | 4,114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | molecular_function | Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate. | [
"PMID:35216259",
"RHEA:14653"
] | null | [
"3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity",
"3',5' cyclic-nucleotide phosphodiesterase activity",
"3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity",
"3',5'-cyclonucleotide phosphodiesterase activity",
"3',5'-nucleotide phosphodiesterase activity",
"3': 5'-monophosphate pho... | [
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.1.4.17",
"MetaCyc:3.1.4.17-RXN",
"Reactome:R-HSA-162425 \"p-S295-PDE3B hydrolyses cAMP to AMP\"",
"RHEA:14653",
"RHEA:70575",
"RHEA:72675"
] | [
"GO:0004112"
] | [] | [] | [] | [
"GO:0004112"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.4.17",
"skos:exactMatch RHEA:14653",
"skos:narrowMatch RHEA:70575",
"skos:narrowMatch RHEA:72675",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004115 | 4,115 | 3',5'-cyclic-AMP phosphodiesterase activity | molecular_function | Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+. | [
"GOC:ai",
"RHEA:25277"
] | null | [
"3',5' cAMP-specific phosphodiesterase activity",
"3',5'-cAMP-specific phosphodiesterase activity",
"3',5'-cyclic-AMP-specific phosphodiesterase activity",
"adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity",
"cAMP-specific phosphodiesterase activity",
"cyclic AMP-specific phosphodiestera... | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [
"EC:3.1.4.53",
"MetaCyc:RXN0-5038",
"Reactome:R-HSA-111962 \"PDE4A,C,D hydrolyse cAMP\"",
"Reactome:R-HSA-418553 \"cAMP degradation by Phosphodiesterases\"",
"Reactome:R-HSA-9629675 \"PDE3A hydrolyses cAMP to AMP\"",
"Reactome:R-HSA-9644869 \"p-S54-PDE4B hydrolyses cAMP\"",
"Reactome:R-HSA-9705507 \"PDE... | [
"GO:0004114"
] | [] | [] | [] | [
"GO:0004114"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.4.53",
"skos:exactMatch RHEA:25277",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004117 | 4,117 | calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity | molecular_function | Catalysis of the reactions: 3',5'-cyclic AMP + H2O = AMP + H+ and 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin. | [
"PMID:8557689",
"PMID:9419816"
] | null | [
"calmodulin-activated cyclic-nucleotide dual specificity phosphodiesterase activity",
"calmodulin-dependent cyclic-nucleotide phosphodiesterase activity"
] | [
"RELATED",
"BROAD"
] | [] | [] | [
"Reactome:R-HSA-111955 \"cAMP hydrolysis by Cam-PDE 1\""
] | [
"GO:0004115",
"GO:0047555"
] | [] | [] | [] | [
"GO:0004115",
"GO:0047555"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:3.1.4.35",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22791\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004118 | 4,118 | 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | molecular_function | Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP. | [
"GOC:mah",
"PMID:15210692",
"PMID:35216259"
] | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | [] | [] | [] | [] | [] | [
"GO:0004114"
] | [] | [] | [] | [
"GO:0004114"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:3.1.4.17",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20117\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004119 | 4,119 | 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity | molecular_function | Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP. | [
"GOC:mah",
"PMID:35216259"
] | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity | [] | [] | [] | [] | [] | [
"GO:0004114"
] | [] | [] | [] | [
"GO:0004114"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:3.1.4.17",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20117\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004120 | 4,120 | obsolete photoreceptor cyclic-nucleotide phosphodiesterase activity | molecular_function | OBSOLETE. Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide. | [
"GOC:curators"
] | The reason for obsoletion is that this term represents a gene product. | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20117\" xsd:anyURI"
] | null | null | true | true | 1 |
GO:0004121 | 4,121 | obsolete cystathionine beta-lyase activity | molecular_function | OBSOLETE. Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate. | [
"GOC:curators"
] | The reason for obsoletion is that this term is equivalent to GO:0047804 cysteine-S-conjugate beta-lyase activity. | [] | [] | [
"GO:0008799"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0047804"
] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27410\" xsd:anyURI"
] | null | null | true | true | 4 |
GO:0004122 | 4,122 | cystathionine beta-synthase activity | molecular_function | Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O. | [
"EC:4.2.1.22"
] | null | [
"beta-thionase activity",
"L-serine hydro-lyase (adding homocysteine)",
"L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)",
"methylcysteine synthase activity",
"serine sulfhydrase activity",
"serine sulfhydrylase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.2.1.22",
"MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN",
"Reactome:R-HSA-1614524 \"PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine\"",
"RHEA:10112"
] | [
"GO:0016836"
] | [] | [] | [] | [
"GO:0016836"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.2.1.22",
"skos:exactMatch RHEA:10112",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004123 | 4,123 | cystathionine gamma-lyase activity | molecular_function | Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+. | [
"RHEA:14005"
] | null | [
"gamma-cystathionase activity",
"homoserine deaminase activity",
"homoserine deaminase-cystathionase activity",
"homoserine dehydratase activity",
"L-cystathionine cysteine-lyase (deaminating)",
"L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)"
] | [
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED"
] | [
"GO:0016225"
] | [] | [
"KEGG_REACTION:R01001",
"MetaCyc:RXN-15130",
"Reactome:R-HSA-1614583 \"PXLP-K212-CTH cleaves L-Cystathionine\"",
"RHEA:14005"
] | [
"GO:0016846"
] | [] | [] | [] | [
"GO:0016846"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:4.4.1.1",
"skos:exactMatch RHEA:14005",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28011\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004124 | 4,124 | cysteine synthase activity | molecular_function | Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate. | [
"EC:2.5.1.47"
] | null | [
"3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity",
"acetylserine sulfhydrylase activity",
"cysteine synthase activity, acting on O-acetyl-L-serine",
"cysteine synthetase activity",
"O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity",
"O-acetyl-L-serine s... | [
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.5.1.47",
"MetaCyc:ACSERLY-RXN",
"RHEA:14829"
] | [
"GO:0016765"
] | [
"part_of GO:0019344"
] | [
"part_of"
] | [
"GO:0019344"
] | [
"GO:0016765",
"GO:0019344"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.5.1.47",
"skos:exactMatch RHEA:14829",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004125 | 4,125 | L-seryl-tRNA(Sec) selenium transferase activity | molecular_function | Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate. | [
"RHEA:22728"
] | null | [
"cysteinyl-tRNA(Sec)-selenium transferase activity",
"cysteinyl-tRNA(Sel)-selenium transferase activity",
"cysteinyl-tRNA(Ser) selenium transferase activity",
"cysteinyl-tRNASec-selenium transferase activity",
"cysteinyl-tRNASel-selenium transferase activity",
"L-selenocysteinyl-tRNA(Sec) synthase activit... | [
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"EXACT",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:2.9.1.1",
"MetaCyc:2.9.1.1-RXN",
"RHEA:22728"
] | [
"GO:0016785",
"GO:0140101"
] | [] | [] | [] | [
"GO:0016785",
"GO:0140101"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.9.1.1",
"skos:exactMatch RHEA:22728",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004126 | 4,126 | cytidine deaminase activity | molecular_function | Catalysis of the reaction: cytidine + H+ + H2O = uridine + NH4 and deoxycytidine + H+ + H2O = deoxyuridine + NH4+. | [
"EC:3.5.4.5"
] | null | [
"(deoxy)cytidine deaminase activity",
"cytidine aminohydrolase activity",
"cytosine nucleoside deaminase activity",
"deoxycytidine deaminase activity"
] | [
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.4.5",
"MetaCyc:CYTIDEAM-RXN",
"MetaCyc:CYTIDEAM2-RXN",
"Reactome:R-HSA-73608 \"(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)\"",
"Reactome:R-HSA-83677 \"C4 deamination of cytidine\"",
"Reactome:R-HSA-9817513 \"AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidi... | [
"GO:0016814",
"GO:0019239"
] | [] | [] | [] | [
"GO:0016814",
"GO:0019239"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.4.5",
"skos:narrowMatch MetaCyc:CYTIDEAM-RXN",
"skos:narrowMatch MetaCyc:CYTIDEAM2-RXN",
"skos:narrowMatch RHEA:13433",
"skos:narrowMatch RHEA:16069",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27410\" xsd:anyURI",
"term_tracker_item \"https://github.... | null | null | false | true | 3 |
GO:0004127 | 4,127 | obsolete (d)CMP kinase activity | molecular_function | OBSOLETE. Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP. | [
"GOC:rynl"
] | The reason for obsoletion is that this term was an unnecessary grouping term. | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0036430",
"GO:0036431"
] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25991\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29533\" xsd:anyURI"
] | null | null | true | true | 9 |
GO:0004128 | 4,128 | cytochrome-b5 reductase activity, acting on NAD(P)H | molecular_function | Catalysis of the reaction: 2 Fe(III)-[cytochrome b5] + NAD(P)H = 2 Fe(II)-[cytochrome b5] + NAD(P)+ + H+. | [
"GOC:curators"
] | null | [] | [] | [] | [] | [
"Reactome:R-HSA-198824 \"CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme\"",
"Reactome:R-HSA-6806831 \"CYB5Rs reduce MetHb to HbA\""
] | [
"GO:0016653"
] | [] | [] | [] | [
"GO:0016653"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30105\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004129 | 4,129 | cytochrome-c oxidase activity | molecular_function | Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out). | [
"RHEA:11436"
] | The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment. | [
"aa3-type cytochrome c oxidase",
"ba3-type cytochrome c oxidase",
"caa3-type cytochrome c oxidase",
"cbb3-type cytochrome c oxidase",
"complex IV (mitochondrial electron transport) activity",
"cytochrome a3 activity",
"cytochrome aa3 activity",
"cytochrome c oxidase activity",
"cytochrome oxidase ac... | [
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"RELATED",
"NARROW",
"NARROW",
"EXACT",
"RELATED",
"NARROW",
"NARROW",
"RELATED"
] | [] | [] | [
"EC:7.1.1.9",
"MetaCyc:CYTOCHROME-C-OXIDASE-RXN",
"Reactome:R-HSA-163214 \"Electron transfer from reduced cytochrome c to molecular oxygen\"",
"RHEA:11436"
] | [
"GO:0009055",
"GO:0015078",
"GO:0015453",
"GO:0022853"
] | [
"has_part GO:0016675"
] | [
"has_part"
] | [
"GO:0016675"
] | [
"GO:0009055",
"GO:0015078",
"GO:0015453",
"GO:0016675",
"GO:0022853"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:7.1.1.9",
"skos:exactMatch RHEA:11436",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20924\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21275\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontolo... | null | null | false | true | 5 |
GO:0004130 | 4,130 | cytochrome-c peroxidase activity | molecular_function | Catalysis of the reaction: 2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O. | [
"EC:1.11.1.5"
] | null | [
"apocytochrome c peroxidase activity",
"cytochrome c peroxidase activity",
"cytochrome c-551 peroxidase activity",
"cytochrome c-H2O oxidoreductase activity",
"cytochrome peroxidase activity",
"ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity",
"mesocytochrome c peroxidase azide",
"mesocyto... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.11.1.5",
"MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN",
"RHEA:16581"
] | [
"GO:0004601"
] | [] | [] | [] | [
"GO:0004601"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.11.1.5",
"skos:exactMatch RHEA:16581",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004131 | 4,131 | cytosine deaminase activity | molecular_function | Catalysis of the reaction: cytosine + H2O = uracil + NH4+. | [
"RHEA:20605"
] | null | [
"cytosine aminohydrolase activity",
"isocytosine deaminase activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.4.1",
"MetaCyc:CYTDEAM-RXN",
"RHEA:20605"
] | [
"GO:0016814",
"GO:0019239"
] | [] | [] | [] | [
"GO:0016814",
"GO:0019239"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.4.1",
"skos:exactMatch RHEA:20605",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004132 | 4,132 | dCMP deaminase activity | molecular_function | Catalysis of the reaction: dCMP + H2O = dUMP + NH4+. | [
"RHEA:22924"
] | null | [
"dCMP aminohydrolase activity",
"deoxy-CMP-deaminase activity",
"deoxycytidine monophosphate deaminase activity",
"deoxycytidine-5'-monophosphate aminohydrolase activity",
"deoxycytidine-5'-phosphate deaminase activity",
"deoxycytidylate aminohydrolase activity",
"deoxycytidylate deaminase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.4.12",
"MetaCyc:DCMP-DEAMINASE-RXN",
"Reactome:R-HSA-73596 \"dCMP + H2O => dUMP + NH4+\"",
"RHEA:22924"
] | [
"GO:0016814",
"GO:0019239"
] | [] | [] | [] | [
"GO:0016814",
"GO:0019239"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.4.12",
"skos:exactMatch RHEA:22924",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004133 | 4,133 | obsolete glycogen debranching enzyme activity | molecular_function | OBSOLETE. Catalysis of the cleavage of branch points in branched glycogen polymers. | [
"ISBN:0198506732"
] | This term was obsoleted because it represents a gene product. | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004134",
"GO:0004135",
"GO:0120549"
] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29864\" xsd:anyURI"
] | null | null | true | true | 3 |
GO:0004134 | 4,134 | 4-alpha-glucanotransferase activity | molecular_function | Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan. | [
"EC:2.4.1.25"
] | null | [
"1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity",
"amylomaltase activity",
"D-enzyme activity",
"debranching enzyme maltodextrin glycosyltransferase activity",
"dextrin glycosyltransferase activity",
"dextrin transglycosylase activity",
"disproportionating enzyme activity",... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.1.25",
"MetaCyc:AMYLOMALT-RXN",
"MetaCyc:RXN-1828",
"MetaCyc:RXN-9023",
"Reactome:R-HSA-71552 \"limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin\""
] | [
"GO:0016758"
] | [] | [] | [] | [
"GO:0016758"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.25",
"skos:narrowMatch MetaCyc:AMYLOMALT-RXN",
"skos:narrowMatch MetaCyc:RXN-1828",
"skos:narrowMatch MetaCyc:RXN-9023",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28526\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004135 | 4,135 | amylo-alpha-1,6-glucosidase activity | molecular_function | Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages ... | [
"EC:3.2.1.33"
] | null | [
"amylo-1,6-glucosidase activity",
"amylopectin 1,6-glucosidase activity",
"dextrin 6-alpha-D-glucosidase activity",
"dextrin-1,6-glucosidase activity",
"glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity"
] | [
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.2.1.33",
"MetaCyc:3.2.1.33-RXN",
"Reactome:R-HSA-71593 \"((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose\""
] | [
"GO:0090599"
] | [] | [] | [] | [
"GO:0090599"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.33",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004136 | 4,136 | deoxyadenosine kinase activity | molecular_function | Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H+. | [
"EC:2.7.1.76",
"RHEA:23452"
] | null | [
"ATP:deoxyadenosine 5'-phosphotransferase activity",
"deoxyadenosine kinase (phosphorylating)",
"purine-deoxyribonucleoside kinase activity"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.76",
"KEGG_REACTION:R02089",
"MetaCyc:DEOXYADENOSINE-KINASE-RXN",
"RHEA:23452"
] | [
"GO:0019136"
] | [
"part_of GO:0006170"
] | [
"part_of"
] | [
"GO:0006170"
] | [
"GO:0006170",
"GO:0019136"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.76",
"skos:exactMatch RHEA:23452",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004137 | 4,137 | deoxycytidine kinase activity | molecular_function | Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP. | [
"EC:2.7.1.74"
] | null | [
"2'-deoxycytidine kinase activity",
"Ara-C kinase activity",
"arabinofuranosylcytosine kinase activity",
"deoxycytidine kinase (phosphorylating)",
"deoxycytidine-cytidine kinase activity",
"NTP:deoxycytidine 5'-phosphotransferase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.74",
"MetaCyc:DEOXYCYTIDINE-KINASE-RXN",
"RHEA:20061",
"RHEA:46036",
"RHEA:46040"
] | [
"GO:0019136"
] | [] | [] | [] | [
"GO:0019136"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.74",
"skos:exactMatch RHEA:20061",
"skos:narrowMatch RHEA:46036",
"skos:narrowMatch RHEA:46040",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004138 | 4,138 | deoxyguanosine kinase activity | molecular_function | Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H+. | [
"EC:2.7.1.113",
"RHEA:19201"
] | null | [
"(dihydroxypropoxymethyl)guanine kinase activity",
"2'-deoxyguanosine kinase activity",
"ATP:deoxyguanosine 5'-phosphotransferase activity",
"deoxyguanosine kinase (phosphorylating)",
"NTP-deoxyguanosine 5'-phosphotransferase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.113",
"KEGG_REACTION:R01967",
"MetaCyc:DEOXYGUANOSINE-KINASE-RXN",
"RHEA:19201"
] | [
"GO:0019136"
] | [] | [] | [] | [
"GO:0019136"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.113",
"skos:exactMatch RHEA:19201",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004139 | 4,139 | deoxyribose-phosphate aldolase activity | molecular_function | Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. | [
"EC:4.1.2.4",
"RHEA:12821"
] | null | [
"2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)",
"2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity",
"2-deoxyribose-5-phosphate aldolase activity",
"deoxyriboaldolase activity",
"deoxyribose-5-phosphate aldolase activity",
"phosphodeoxyriboaldolase activity... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.1.2.4",
"KEGG_REACTION:R01066",
"MetaCyc:DEOXYRIBOSE-P-ALD-RXN",
"Reactome:R-HSA-6787321 \"DERA cleaves dR5P to GA3P and CH3CHO\"",
"RHEA:12821"
] | [
"GO:0016832"
] | [] | [] | [] | [
"GO:0016832"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.2.4",
"skos:exactMatch RHEA:12821",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004140 | 4,140 | dephospho-CoA kinase activity | molecular_function | Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+. | [
"EC:2.7.1.24",
"RHEA:18245"
] | null | [
"3'-dephospho-CoA kinase activity",
"ATP:dephospho-CoA 3'-phosphotransferase activity",
"dephosphocoenzyme A kinase (phosphorylating)",
"dephosphocoenzyme A kinase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.24",
"KEGG_REACTION:R00130",
"MetaCyc:DEPHOSPHOCOAKIN-RXN",
"Reactome:R-HSA-196773 \"COASY phosphorylates DP-CoA\"",
"Reactome:R-HSA-9837337 \"DCAKD phosphorylates DP-CoA\"",
"RHEA:18245"
] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.24",
"skos:exactMatch RHEA:18245",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004141 | 4,141 | dethiobiotin synthase activity | molecular_function | Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO2 = ADP + dethiobiotin + 4 H+ + phosphate. | [
"EC:6.3.3.3",
"RHEA:15805"
] | null | [
"7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)",
"desthiobiotin synthase activity",
"DTB synthetase activity"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.3.3.3",
"KEGG_REACTION:R03182",
"MetaCyc:DETHIOBIOTIN-SYN-RXN",
"RHEA:15805"
] | [
"GO:0016882"
] | [] | [] | [] | [
"GO:0016882"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.3.3",
"skos:exactMatch RHEA:15805",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004142 | 4,142 | diacylglycerol cholinephosphotransferase activity | molecular_function | Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine. | [
"EC:2.7.8.2",
"RHEA:32939"
] | null | [
"1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity",
"1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity",
"1-alkyl-2-acetylglycerol cholinephosphotransferase activity",
"alkylacylglycerol choline phosphotransferase activity",
"alkylacylglycerol cholinephosphotransferas... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.8.2",
"MetaCyc:RXN-5781",
"Reactome:R-HSA-1482961 \"CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane\"",
"Reactome:R-HSA-1482973 \"CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane\"",
"RHEA:32939",
"RHEA:54232",
"RHEA:54236",
"RHEA:54240",
"RHEA:54244",
"RH... | [
"GO:0017169"
] | [
"part_of GO:0006657"
] | [
"part_of"
] | [
"GO:0006657"
] | [
"GO:0006657",
"GO:0017169"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.8.2",
"skos:exactMatch RHEA:32939",
"skos:narrowMatch RHEA:54232",
"skos:narrowMatch RHEA:54236",
"skos:narrowMatch RHEA:54240",
"skos:narrowMatch RHEA:54244",
"skos:narrowMatch RHEA:54332",
"skos:narrowMatch RHEA:54336",
"skos:narrowMatch RHEA:54344",
"term_tracker_item \"... | null | null | false | true | 8 |
GO:0004143 | 4,143 | ATP-dependent diacylglycerol kinase activity | molecular_function | Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+. | [
"GOC:elh",
"RHEA:10272"
] | null | [
"DGK activity",
"diacylglycerol kinase activity",
"diacylglycerol kinase activity (ATP)",
"diglyceride kinase activity"
] | [
"RELATED",
"BROAD",
"EXACT",
"BROAD"
] | [] | [] | [
"EC:2.7.1.107",
"MetaCyc:DIACYLGLYKIN-RXN",
"Reactome:R-HSA-426240 \"DAG kinase produces phosphatidic acid from DAG\"",
"RHEA:10272",
"RHEA:40323",
"RHEA:40327",
"RHEA:40335",
"RHEA:40359",
"RHEA:43416",
"RHEA:43424",
"RHEA:43428",
"RHEA:63324"
] | [
"GO:0001727",
"GO:0016773"
] | [] | [] | [] | [
"GO:0001727",
"GO:0016773"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.107",
"skos:exactMatch RHEA:10272",
"skos:narrowMatch RHEA:40323",
"skos:narrowMatch RHEA:40327",
"skos:narrowMatch RHEA:40335",
"skos:narrowMatch RHEA:40359",
"skos:narrowMatch RHEA:43416",
"skos:narrowMatch RHEA:43424",
"skos:narrowMatch RHEA:43428",
"skos:narrowMatch R... | null | null | false | true | 9 |
GO:0004144 | 4,144 | diacylglycerol O-acyltransferase activity | molecular_function | Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. | [
"EC:2.3.1.20"
] | null | [
"1,2-diacylglycerol acyltransferase activity",
"acyl-CoA:1,2-diacylglycerol O-acyltransferase activity",
"diacylglycerol acyltransferase activity",
"diglyceride acyltransferase activity",
"diglyceride O-acyltransferase activity",
"palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.3.1.20",
"MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN",
"Reactome:R-HSA-1482889 \"DAG is acylated to TAG by DGAT1/2\"",
"Reactome:R-HSA-549192 \"1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]\"",
"Reactome:R-HSA-75900 \"1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGA... | [
"GO:0016411"
] | [] | [] | [] | [
"GO:0016411"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.20",
"skos:exactMatch RHEA:10868",
"skos:narrowMatch RHEA:38163",
"skos:narrowMatch RHEA:38219",
"skos:narrowMatch RHEA:38299",
"skos:narrowMatch RHEA:38307",
"skos:narrowMatch RHEA:56536",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:an... | null | null | false | true | 7 |
GO:0004145 | 4,145 | diamine N-acetyltransferase activity | molecular_function | Catalysis of the reaction: an alkane-alpha,omega-diamine + acetyl-CoA = an N-acetylalkane-alpha,omega-diamine + CoA + H+. | [
"RHEA:11116"
] | null | [
"acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity",
"acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity",
"diamine acetyltransferase activity",
"putrescine (diamine)-acetylating enzyme activity",
"putrescine acetylase activity",
"putrescine acetyltransferase activity",
"p... | [
"RELATED",
"NARROW",
"EXACT",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"RELATED"
] | [] | [] | [
"EC:2.3.1.57",
"MetaCyc:DIAMACTRANS-RXN",
"Reactome:R-HSA-351207 \"Spermine => N-acetylated spermine\"",
"Reactome:R-HSA-351208 \"Spermidine => N-acetylated spermidine\"",
"RHEA:11116",
"RHEA:25181",
"RHEA:28150",
"RHEA:28270",
"RHEA:79547",
"RHEA:79551"
] | [
"GO:0008080"
] | [] | [] | [] | [
"GO:0008080"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.57",
"skos:exactMatch RHEA:11116",
"skos:narrowMatch RHEA:25181",
"skos:narrowMatch RHEA:28150",
"skos:narrowMatch RHEA:28270",
"skos:narrowMatch RHEA:79547",
"skos:narrowMatch RHEA:79551",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30342\" xsd:an... | null | null | false | true | 6 |
GO:0004146 | 4,146 | dihydrofolate reductase activity | molecular_function | Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. | [
"EC:1.5.1.3"
] | null | [
"5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity",
"7,8-dihydrofolate reductase activity",
"DHFR",
"dihydrofolate reductase:thymidylate synthase activity",
"dihydrofolate reduction",
"dihydrofolic acid reductase activity",
"dihydrofolic reductase activity",
"folic acid reductase activity",
"f... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.5.1.3",
"MetaCyc:DIHYDROFOLATEREDUCT-RXN",
"Reactome:R-HSA-1497794 \"Salvage - BH2 is reduced to BH4 by DHFR\"",
"RHEA:15009"
] | [
"GO:0016646"
] | [] | [] | [] | [
"GO:0016646"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.5.1.3",
"skos:exactMatch RHEA:15009",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004148 | 4,148 | dihydrolipoyl dehydrogenase (NADH) activity | molecular_function | Catalysis of the reaction: N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD+ = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H+. | [
"RHEA:15045"
] | null | [
"dehydrolipoate dehydrogenase activity",
"diaphorase activity",
"dihydrolipoamide dehydrogenase activity",
"dihydrolipoamide reduction",
"dihydrolipoamide:NAD+ oxidoreductase",
"dihydrolipoic dehydrogenase activity",
"dihydrolipoylprotein reduction",
"dihydrothioctic dehydrogenase activity",
"E3 com... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.8.1.4",
"MetaCyc:1.8.1.4-RXN",
"Reactome:R-HSA-1222412 \"LpdC dimer reactivates DlaT\"",
"Reactome:R-HSA-5694018 \"DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate\"",
"Reactome:R-HSA-9853499 \"DLD dimer dehydrogenates dihydrolipoyl\"",
"Reactome:R-HSA-9858589 \"DLD dimer dehydrogenates dihydrolip... | [
"GO:0016668"
] | [] | [] | [] | [
"GO:0016668"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:1.2.1.104",
"skos:broadMatch EC:1.2.1.105",
"skos:broadMatch EC:1.2.1.25",
"skos:broadMatch EC:1.4.1.27",
"skos:broadMatch KEGG_REACTION:R08549",
"skos:broadMatch MetaCyc:1.2.1.25-RXN",
"skos:broadMatch MetaCyc:2OXOGLUTARATEDEH-RXN",
"skos:broadMatch MetaCyc:GCVMULTI-RXN",
"skos:... | null | null | false | true | 6 |
GO:0004149 | 4,149 | dihydrolipoyllysine-residue succinyltransferase activity | molecular_function | Catalysis of the reaction: N(6)-[(R)-dihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA. | [
"RHEA:15213"
] | null | [
"dihydrolipoamide S-succinyltransferase activity",
"dihydrolipoamide succinyltransferase activity",
"dihydrolipoic transsuccinylase activity",
"dihydrolipolyl transsuccinylase activity",
"dihydrolipoyl transsuccinylase activity",
"enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity",
... | [
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.3.1.61",
"Reactome:R-HSA-9853512 \"DLST transfers succinyl to CoA\"",
"RHEA:15213"
] | [
"GO:0016751",
"GO:0140096"
] | [] | [] | [] | [
"GO:0016751",
"GO:0140096"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:1.2.1.105",
"skos:broadMatch KEGG_REACTION:R08549",
"skos:broadMatch MetaCyc:2OXOGLUTARATEDEH-RXN",
"skos:broadMatch RHEA:27786",
"skos:exactMatch EC:2.3.1.61",
"skos:exactMatch RHEA:15213",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29951\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004150 | 4,150 | dihydroneopterin aldolase activity | molecular_function | Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde. | [
"EC:4.1.2.25"
] | null | [
"2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)",
"2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.1.2.25",
"MetaCyc:H2NEOPTERINALDOL-RXN",
"RHEA:10540"
] | [
"GO:0016832"
] | [] | [] | [] | [
"GO:0016832"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.2.25",
"skos:exactMatch RHEA:10540",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004151 | 4,151 | dihydroorotase activity | molecular_function | Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H+. | [
"EC:3.5.2.3",
"RHEA:24296"
] | null | [
"(S)-dihydroorotate amidohydrolase activity",
"carbamoylaspartic dehydrase activity",
"DHOase activity",
"dihydroorotate hydrolase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.2.3",
"KEGG_REACTION:R01993",
"MetaCyc:DIHYDROOROT-RXN",
"Reactome:R-HSA-73571 \"CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO\"",
"RHEA:24296"
] | [
"GO:0016812"
] | [] | [] | [] | [
"GO:0016812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.2.3",
"skos:exactMatch RHEA:24296",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004152 | 4,152 | dihydroorotate dehydrogenase activity | molecular_function | Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate. | [
"RHEA:18073"
] | null | [] | [] | [] | [] | [
"KEGG_REACTION:R01868",
"MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN",
"Reactome:R-HSA-73569 \"DHODH:FMN oxidises (S)-DHO to orotate\"",
"RHEA:18073"
] | [
"GO:0016627"
] | [] | [] | [] | [
"GO:0016627"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch RHEA:18073",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23786\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004153 | 4,153 | dihydropterin deaminase activity | molecular_function | Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH4+. | [
"GOC:jl",
"PMID:19567870",
"PMID:38786926"
] | null | [] | [] | [] | [] | [
"MetaCyc:RXN-15261"
] | [
"GO:0016814",
"GO:0019239"
] | [] | [] | [] | [
"GO:0016814",
"GO:0019239"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19833\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28340\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004154 | 4,154 | dihydropterin oxidase activity | molecular_function | Catalysis of the reaction: a 7,8-dihydropteridine compound + O2 = an oxidized 7,8-dihydropteridine compound + H2O2. Specific substrates and their fully oxidized products include: 7,8-dihydropteridin/pterin, 7,8-dihydrobiopterin/biopterin, 7,8-dihydroxanthopterin/xanthopterin and sepiapterin/oxidized sepiapterin. | [
"GOC:sjm",
"PMID:1745247",
"PMID:38786926",
"PMID:6815189"
] | null | [] | [] | [] | [] | [
"MetaCyc:RXN-15269"
] | [
"GO:0016647"
] | [] | [] | [] | [
"GO:0016647"
] | [] | [] | [] | [] | [] | [
"skos:narrowMatch MetaCyc:RXN-15269",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28340\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29654\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004155 | 4,155 | 6,7-dihydropteridine reductase activity | molecular_function | Catalysis of the reaction: NAD(P)+ + 5,6,7,8-tetrahydropteridine = NAD(P)H + H+ + 6,7-dihydropteridine. | [
"EC:1.5.1.34"
] | null | [
"5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity",
"5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity",
"6,7-dihydropteridine:NAD(P)H oxidoreductase activity",
"DHPR activity",
"dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity",
"dihydropteridine reduc... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.5.1.34",
"MetaCyc:1.5.1.34-RXN",
"Reactome:R-HSA-71130 \"q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+\"",
"RHEA:17865",
"RHEA:17869"
] | [
"GO:0016646"
] | [] | [] | [] | [
"GO:0016646"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.5.1.34",
"skos:exactMatch MetaCyc:1.5.1.34-RXN",
"skos:narrowMatch RHEA:17865",
"skos:narrowMatch RHEA:17869",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29460\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004156 | 4,156 | dihydropteroate synthase activity | molecular_function | Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. | [
"EC:2.5.1.15"
] | null | [
"(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity",
"2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity",
"7,8-dihydropt... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.5.1.15",
"MetaCyc:H2PTEROATESYNTH-RXN",
"RHEA:19949"
] | [
"GO:0016765"
] | [] | [] | [] | [
"GO:0016765"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.5.1.15",
"skos:exactMatch RHEA:19949",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004157 | 4,157 | dihydropyrimidinase activity | molecular_function | Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate. | [
"EC:3.5.2.2"
] | null | [
"5,6-dihydropyrimidine amidohydrolase activity",
"D-hydantoinase activity",
"hydantoin peptidase activity",
"hydantoinase activity",
"hydropyrimidine hydrase activity",
"pyrimidine hydrase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.2.2",
"MetaCyc:DIHYDROPYRIMIDINASE-RXN",
"Reactome:R-HSA-73589 \"5,6-dihydrouracil + H2O => beta-ureidopropionate\"",
"Reactome:R-HSA-73618 \"5,6-dihydrothymine + H2O => beta-ureidoisobutyrate\"",
"RHEA:16121"
] | [
"GO:0016812"
] | [] | [] | [] | [
"GO:0016812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.2.2",
"skos:exactMatch RHEA:16121",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004158 | 4,158 | obsolete dihydroorotate oxidase activity | molecular_function | OBSOLETE. Catalysis of the reaction: (S)-dihydroorotate + O2 = H2O2 + orotate. | [
"GOC:curators"
] | There appears to be no evidence for this reaction. The original EC used for this reaction was not appropriate. | [
"(S)-dihydroorotate:oxygen oxidoreductase activity",
"4,5-L-dihydroorotate:oxygen oxidoreductase activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23786\" xsd:anyURI"
] | null | null | true | true | 5 |
GO:0004159 | 4,159 | dihydropyrimidine dehydrogenase (NAD+) activity | molecular_function | Catalysis of the reaction: a 5,6-dihydropyrimidine (5,6-dihydrouracil or 5,6-dihydrothymine) + NAD+ = a pyrimidine (uracil or thymine) + NADH + H+. | [
"PMID:23150645"
] | null | [
"5,6-dihydrouracil:NAD+ oxidoreductase activity",
"dihydrothymine dehydrogenase (NAD+) activity",
"dihydrouracil dehydrogenase (NAD+) activity",
"pyrimidine reductase activity",
"thymine reductase activity",
"uracil reductase activity"
] | [
"RELATED",
"NARROW",
"NARROW",
"RELATED",
"NARROW",
"NARROW"
] | [] | [] | [
"EC:1.3.1.1",
"MetaCyc:DIHYDROURACIL-DEHYDROGENASE-NAD+-RXN",
"RHEA:20189",
"RHEA:28791"
] | [
"GO:0016628"
] | [] | [] | [] | [
"GO:0016628"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.3.1.1",
"skos:narrowMatch RHEA:20189",
"skos:narrowMatch RHEA:28791",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21891\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004161 | 4,161 | dimethylallyltranstransferase activity | molecular_function | Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = (2E)-geranyl diphosphate + diphosphate. | [
"RHEA:22408"
] | Note that this is the first step in the formation of farnesyl diphosphate. The second step is 'geranyltranstransferase activity ; GO:0004337'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. | [
"(2E,6E)-farnesyl diphosphate synthetase activity",
"dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity",
"dimethylallyltransferase activity",
"diprenyltransferase activity",
"DMAPP:IPP-dimethylallyltransferase activity",
"geranyl diphosphate synthase activity",
"ge... | [
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.5.1.1",
"MetaCyc:GPPSYN-RXN",
"Reactome:R-HSA-191322 \"FDPS dimer transfers IPPP to DMAPP\"",
"Reactome:R-HSA-9717834 \"GGPS1 hexamer transfers IPPP to DMAPP\"",
"RHEA:22408"
] | [
"GO:0120531"
] | [] | [] | [] | [
"GO:0120531"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.5.1.1",
"skos:exactMatch RHEA:22408",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20661\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28819\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontolo... | null | null | false | true | 7 |
GO:0004163 | 4,163 | diphosphomevalonate decarboxylase activity | molecular_function | Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO2 + H+ + isopentenyl diphosphate + phosphate. | [
"EC:4.1.1.33",
"RHEA:23732"
] | null | [
"5-pyrophosphomevalonate decarboxylase activity",
"ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)",
"ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)",
"mevalonate 5-diphosphate decarboxylase activity",
"mevalonate diphosphate decarboxylase activity",
"m... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.1.1.33",
"KEGG_REACTION:R01121",
"MetaCyc:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN",
"Reactome:R-HSA-191414 \"MVD decarboxylates MVA5PP to IPPP\"",
"RHEA:23732"
] | [
"GO:0016831"
] | [] | [] | [] | [
"GO:0016831"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.1.33",
"skos:exactMatch RHEA:23732",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004164 | 4,164 | diphthine synthase activity | molecular_function | Catalysis of the reaction: 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H+ + 3 S-adenosyl-L-homocysteine. | [
"PMID:15485916",
"PMID:20873788",
"PMID:3042777",
"RHEA:36415"
] | This activity is present in archae and produces the trimethylated product diphthine, which is converted into diphthamide by diphthine-ammonia ligase activity ; GO:0017178 (EC:6.3.1.14). Note that this is different from the eukaryotic enzyme diphthine methyl ester synthase activity ; GO:0141133 (EC:2.1.1.314), which pro... | [
"diphthine methyltransferase activity",
"S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity",
"S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.1.1.98",
"MetaCyc:RXN-14326",
"RHEA:36415"
] | [
"GO:0008276",
"GO:0008757"
] | [] | [] | [] | [
"GO:0008276",
"GO:0008757"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.1.1.98",
"skos:exactMatch RHEA:36415",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25281\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25795\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontol... | null | null | false | true | 7 |
GO:0004165 | 4,165 | delta(3)-delta(2)-enoyl-CoA isomerase activity | molecular_function | Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA. | [
"RHEA:45900"
] | null | [
"3,2-trans-enoyl-CoA isomerase activity",
"acetylene-allene isomerase activity",
"delta(3),delta(2)-enoyl-CoA isomerase activity",
"delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase activity",
"delta3,delta2-enoyl-CoA isomerase activity",
"delta3-cis-delta2-trans-enoyl-CoA isomerase",
"delta3-delta2 enoyl... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"EXACT",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"RELATED"
] | [
"GO:0008461"
] | [] | [
"EC:5.3.3.8",
"MetaCyc:ENOYL-COA-DELTA-ISOM-RXN",
"MetaCyc:RXN-7836",
"MetaCyc:RXN-7931",
"Reactome:R-HSA-109338 \"Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA\"",
"Reactome:R-HSA-6809808 \"ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA\"",
"RHEA:23716",
"RHEA:2... | [
"GO:0016863"
] | [] | [] | [] | [
"GO:0016863"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.3.3.8",
"skos:exactMatch RHEA:45900",
"skos:narrowMatch MetaCyc:ENOYL-COA-DELTA-ISOM-RXN",
"skos:narrowMatch MetaCyc:RXN-7836",
"skos:narrowMatch MetaCyc:RXN-7931",
"skos:narrowMatch RHEA:23716",
"skos:narrowMatch RHEA:29847",
"skos:narrowMatch RHEA:45228",
"skos:narrowMatch RH... | null | null | false | true | 2 |
GO:0004166 | 4,166 | dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity | molecular_function | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate. | [
"EC:2.4.1.153"
] | null | [
"dolichyl phosphate acetylglucosaminyltransferase activity",
"dolichyl phosphate N-acetylglucosaminyltransferase activity",
"dolichyl-phosphate acetylglucosaminyltransferase activity",
"dolichyl-phosphate N-acetylglucosaminyltransferase activity",
"UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acety... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [
"GO:0004101"
] | [] | [
"EC:2.4.1.153",
"MetaCyc:2.4.1.153-RXN",
"RHEA:14693"
] | [
"GO:0008375"
] | [] | [] | [] | [
"GO:0008375"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.153",
"skos:exactMatch RHEA:14693",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004167 | 4,167 | dopachrome isomerase activity | molecular_function | Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate. | [
"EC:5.3.3.12",
"RHEA:13041"
] | null | [
"DCF activity",
"DCT activity",
"dopachrome conversion activity",
"dopachrome conversion factor activity",
"dopachrome Delta(7),Delta(2)-isomerase activity",
"dopachrome delta-isomerase activity",
"dopachrome delta7,Delta2-isomerase activity",
"dopachrome keto-enol isomerase activity",
"dopachrome o... | [
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [
"GO:0048059"
] | [] | [
"EC:5.3.3.12",
"KEGG_REACTION:R03673",
"MetaCyc:DOPACHROME-DELTA-ISOMERASE-RXN",
"Reactome:R-HSA-5662660 \"Dopachrome is transformed to DHICA by DCT\"",
"RHEA:13041"
] | [
"GO:0016863"
] | [] | [] | [] | [
"GO:0016863"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.3.3.12",
"skos:exactMatch RHEA:13041",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004168 | 4,168 | dolichol kinase activity | molecular_function | Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate. | [
"EC:2.7.1.108"
] | null | [
"CTP:dolichol O-phosphotransferase activity",
"dolichol phosphokinase activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.108",
"MetaCyc:DOLICHOL-KINASE-RXN",
"Reactome:R-HSA-446195 \"DOLK phosphorylates DCHOL to DOLP\"",
"Reactome:R-HSA-4755600 \"Defective DOLK does not phosphorylate DCHOL\"",
"RHEA:13133"
] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.108",
"skos:exactMatch RHEA:13133",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004169 | 4,169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity | molecular_function | Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein. | [
"EC:2.4.1.109",
"GOC:pr"
] | Note that this activity has never been observed in green plants. However, N- and C-mannosylation may occur in these species; see figure 1 in PMID:21558543. | [
"dolichol phosphomannose-protein mannosyltransferase activity",
"dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity",
"dolichyl-phosphate-mannose-protein O-mannosyltransferase activity",
"O-glycoside mannosyltransferase",
"protein O-D-mannosyltransferase activity",
"protein O-mannosyltr... | [
"RELATED",
"RELATED",
"EXACT",
"BROAD",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:2.4.1.109",
"MetaCyc:2.4.1.109-RXN",
"Reactome:R-HSA-5615556 \"Defective POMT2 does not transfer Man from Dol-P-Man to DAG1\"",
"Reactome:R-HSA-5615604 \"Defective POMT1 does not transfer Man from Dol-P-Man to DAG1\"",
"Reactome:R-HSA-5615637 \"POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653)\""... | [
"GO:0000030",
"GO:0140096"
] | [
"part_of GO:0035269"
] | [
"part_of"
] | [
"GO:0035269"
] | [
"GO:0000030",
"GO:0035269",
"GO:0140096"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.109",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004170 | 4,170 | dUTP diphosphatase activity | molecular_function | Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate. | [
"RHEA:10248"
] | null | [
"deoxyuridine-triphosphatase activity",
"desoxyuridine 5'-triphosphatase activity",
"desoxyuridine 5'-triphosphate nucleotidohydrolase activity",
"dUTP nucleotidohydrolase activity",
"dUTP pyrophosphatase activity",
"dUTPase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED"
] | [] | [
"goslim_chembl"
] | [
"EC:3.6.1.23",
"KEGG_REACTION:R02100",
"MetaCyc:DUTP-PYROP-RXN",
"Reactome:R-HSA-73666 \"dUTP + H2O => dUMP + pyrophosphate\"",
"RHEA:10248"
] | [
"GO:0047429"
] | [] | [] | [] | [
"GO:0047429"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.6.1.23",
"skos:exactMatch RHEA:10248",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004171 | 4,171 | obsolete deoxyhypusine synthase activity | molecular_function | OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. | [
"EC:2.5.1.46"
] | This term was made obsolete because it represents a multistep reaction. | [
"[eIF-5A]-deoxyhypusine synthase",
"deoxyhypusine synthase activity"
] | [
"RELATED",
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0008612",
"GO:0034038"
] | [] | null | null | true | true | 5 |
GO:0004172 | 4,172 | obsolete ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity | molecular_function | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:ai"
] | This term was made obsolete because it represents two molecular functions. | [
"ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0050488"
] | [] | null | null | true | true | 9 |
GO:0004174 | 4,174 | electron-transferring-flavoprotein dehydrogenase activity | molecular_function | Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein]. | [
"RHEA:24052"
] | null | [
"electron transfer flavoprotein dehydrogenase activity",
"electron transfer flavoprotein Q oxidoreductase activity",
"electron transfer flavoprotein reductase activity",
"electron transfer flavoprotein-ubiquinone oxidoreductase activity",
"electron-transferring-flavoprotein:ubiquinone oxidoreductase activit... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.5.5.1",
"MetaCyc:RXN66-550",
"Reactome:R-HSA-169270 \"ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2\"",
"RHEA:24052"
] | [
"GO:0009055",
"GO:0016649"
] | [
"part_of GO:0022904"
] | [
"part_of"
] | [
"GO:0022904"
] | [
"GO:0009055",
"GO:0016649",
"GO:0022904"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.5.5.1",
"skos:exactMatch RHEA:24052"
] | null | null | false | true | 5 |
GO:0004175 | 4,175 | endopeptidase activity | molecular_function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. | [
"http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE"
] | null | [
"elastase activity",
"endoprotease activity",
"proteasome endopeptidase activity",
"proteinase"
] | [
"RELATED",
"NARROW",
"NARROW",
"NARROW"
] | [
"GO:0016809"
] | [] | [
"EC:3.4.99.-",
"Reactome:R-HSA-1168640 \"Ubiquitinated IkB is degraded\"",
"Reactome:R-HSA-1234159 \"Proteasome proteolyzes ub-HIF-alpha\"",
"Reactome:R-HSA-1236935 \"Proteasomal cleavage of substrate (26S proteasome catalyst)\"",
"Reactome:R-HSA-1236970 \"Proteasomal clevage of exogenous antigen (26S prote... | [
"GO:0008233"
] | [] | [] | [] | [
"GO:0008233"
] | [] | [] | [] | [] | [] | [
"skos:narrowMatch EC:3.4.99.-",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25813\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004176 | 4,176 | ATP-dependent peptidase activity | molecular_function | Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. | [
"GOC:mah"
] | null | [
"ATP-dependent proteolysis"
] | [
"RELATED"
] | [
"GO:0004280"
] | [] | [
"Reactome:R-HSA-9698929 \"pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex\"",
"Reactome:R-HSA-9838004 \"LONP1 degrades mitochondrial inner membrane proteins\"",
"Reactome:R-HSA-9838081 \"LONP1 degrades mitochondrial matrix proteins\"",
"Reactome:R-HSA-9838289 \"CLPXP degrades mitochondrial matrix proteins\"",
... | [
"GO:0008233",
"GO:0140657"
] | [] | [] | [] | [
"GO:0008233",
"GO:0140657"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21612\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30980\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004178 | 4,178 | obsolete leucyl aminopeptidase activity | molecular_function | OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro. | [
"GOC:curators"
] | This term was made obsolete because it represents a gene product. | [
"leucyl aminopeptidase activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004177",
"GO:0008235"
] | [] | null | null | true | true | 7 |
GO:0004179 | 4,179 | obsolete membrane alanyl aminopeptidase activity | molecular_function | OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide. | [
"GOC:curators"
] | This term was made obsolete because it represents a gene product. | [
"membrane alanyl aminopeptidase activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004177",
"GO:0008235"
] | [] | null | null | true | true | 4 |
GO:0004180 | 4,180 | carboxypeptidase activity | molecular_function | Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. | [
"https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE"
] | null | [] | [] | [] | [] | [
"EC:3.4.17.11",
"MetaCyc:3.4.17.11-RXN",
"Reactome:R-HSA-1247910 \"CNDP2:2Mn2+ dimer hydrolyses CysGly\"",
"Reactome:R-HSA-9753632 \"CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly\"",
"RHEA:28783"
] | [
"GO:0008238"
] | [] | [] | [] | [
"GO:0008238"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch RHEA:28783",
"skos:narrowMatch EC:3.4.17.11",
"skos:narrowMatch MetaCyc:3.4.17.11-RXN",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19681\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004181 | 4,181 | metallocarboxypeptidase activity | molecular_function | Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. | [
"https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE"
] | null | [] | [] | [] | [] | [
"EC:3.4.17.-",
"EC:3.4.17.1",
"EC:3.4.17.10",
"EC:3.4.17.16",
"EC:3.4.17.2",
"EC:3.4.17.21",
"EC:3.4.17.22",
"EC:3.4.17.3",
"EC:3.4.17.4",
"EC:3.4.17.6",
"MetaCyc:3.4.17.17-RXN",
"MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN",
"MetaCyc:CARBOXYPEPTIDASE-A-RXN",
"MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN",... | [
"GO:0004180",
"GO:0008235"
] | [] | [] | [] | [
"GO:0004180",
"GO:0008235"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.4.17.-",
"skos:narrowMatch EC:3.4.17.1",
"skos:narrowMatch EC:3.4.17.10",
"skos:narrowMatch EC:3.4.17.16",
"skos:narrowMatch EC:3.4.17.2",
"skos:narrowMatch EC:3.4.17.21",
"skos:narrowMatch EC:3.4.17.22",
"skos:narrowMatch EC:3.4.17.3",
"skos:narrowMatch EC:3.4.17.4",
"skos:n... | null | null | false | true | 7 |
GO:0004182 | 4,182 | obsolete carboxypeptidase A activity | molecular_function | OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. | [
"EC:3.4.17.1"
] | This term was made obsolete because it represents a gene product. | [
"carboxypeptidase A activity",
"carboxypolypeptidase activity",
"pancreatic carboxypeptidase A",
"tissue carboxypeptidase A"
] | [
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [
"GO:0008731"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004181"
] | [] | [] | null | null | true | true | 4 |
GO:0004183 | 4,183 | obsolete carboxypeptidase E activity | molecular_function | OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents. | [
"EC:3.4.17.10"
] | This term was made obsolete because it represents a gene product. | [
"carboxypeptidase E activity",
"carboxypeptidase H activity",
"cobalt-stimulated chromaffin granule carboxypeptidase activity",
"enkephalin convertase activity",
"enkephalin precursor carboxypeptidase activity",
"enkephalin-precursor endopeptidase activity",
"insulin granule-associated carboxypeptidase ... | [
"EXACT",
"EXACT",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004181"
] | [] | [] | null | null | true | true | 3 |
GO:0004185 | 4,185 | serine-type carboxypeptidase activity | molecular_function | Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (... | [
"https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE"
] | null | [
"serine carboxypeptidase activity"
] | [
"EXACT"
] | [] | [] | [
"EC:3.4.16.-",
"EC:3.4.16.2",
"EC:3.4.16.5",
"EC:3.4.16.6",
"MetaCyc:3.4.16.2-RXN",
"MetaCyc:3.4.16.5-RXN",
"Reactome:R-HSA-158251 \"prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer\""
] | [
"GO:0004180",
"GO:0070008"
] | [] | [] | [] | [
"GO:0004180",
"GO:0070008"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.4.16.-",
"skos:narrowMatch EC:3.4.16.2",
"skos:narrowMatch EC:3.4.16.5",
"skos:narrowMatch EC:3.4.16.6",
"skos:narrowMatch MetaCyc:3.4.16.2-RXN",
"skos:narrowMatch MetaCyc:3.4.16.5-RXN",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19681\" xsd:anyURI",
... | null | null | false | true | 5 |
GO:0004186 | 4,186 | obsolete carboxypeptidase C activity | molecular_function | OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity. | [
"EC:3.4.16.5"
] | This term was made obsolete because it represents a gene product. | [
"carboxypeptidase C activity",
"carboxypeptidase Y activity",
"cathepsin A activity",
"deamidase",
"lysosomal carboxypeptidase A",
"lysosomal protective protein activity",
"serine carboxypeptidase I activity",
"serine-type carboxypeptidase I activity",
"vacuolar carboxypeptidase Y"
] | [
"EXACT",
"RELATED",
"NARROW",
"RELATED",
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"NARROW"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004185"
] | [] | [] | null | null | true | true | 7 |
GO:0004187 | 4,187 | obsolete carboxypeptidase D activity | molecular_function | OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents. | [
"EC:3.4.16.6"
] | This term was made obsolete because it represents a gene product. | [
"carboxypeptidase D activity",
"carboxypeptidase Kex1",
"carboxypeptidase KEX1 activity",
"carboxypeptidase S1 activity",
"cereal serine carboxypeptidase II",
"CPDW-II",
"gene KEX1 serine carboxypeptidase",
"KEX1 carboxypeptidase activity",
"KEX1 proteinase activity",
"KEX1DELTAp",
"saccharomyce... | [
"EXACT",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004185"
] | [] | [] | null | null | true | true | 1 |
GO:0004188 | 4,188 | obsolete serine-type Pro-X carboxypeptidase activity | molecular_function | OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid. | [
"EC:3.4.16.2"
] | This term was made obsolete because it represents a gene product. | [
"aminoacylproline carboxypeptidase activity",
"angiotensinase C activity",
"lysosomal carboxypeptidase C activity",
"lysosomal Pro-X carboxypeptidase activity",
"lysosomal Pro-Xaa carboxypeptidase activity",
"PCP",
"peptidylprolylamino acid carboxypeptidase activity",
"proline carboxypeptidase activit... | [
"RELATED",
"NARROW",
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [
"GO:0008323"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004185"
] | [] | [] | null | null | true | true | 2 |
GO:0004189 | 4,189 | obsolete tubulinyl-Tyr carboxypeptidase activity | molecular_function | OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr. | [
"EC:3.4.17.17"
] | This term was made obsolete because it represents a gene product. | [
"brain I carboxypeptidase activity",
"carboxypeptidase-tubulin activity",
"soluble carboxypeptidase activity",
"TTCPase activity",
"tubulin carboxypeptidase activity",
"tubulin-tyrosine carboxypeptidase activity",
"tubulinyl-Tyr carboxypeptidase activity",
"tubulinyl-tyrosine carboxypeptidase activity... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004181"
] | [] | [] | null | null | true | true | 4 |
GO:0004190 | 4,190 | aspartic-type endopeptidase activity | molecular_function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. | [
"ISBN:0198506732"
] | null | [
"aspartate protease activity",
"aspartic endopeptidase activity",
"aspartic protease activity",
"aspartyl protease activity",
"carboxyl protease activity"
] | [
"NARROW",
"EXACT",
"NARROW",
"NARROW",
"NARROW"
] | [] | [] | [
"EC:3.4.23.-",
"EC:3.4.23.1",
"EC:3.4.23.15",
"EC:3.4.23.20",
"EC:3.4.23.25",
"EC:3.4.23.32",
"EC:3.4.23.34",
"EC:3.4.23.35",
"EC:3.4.23.36",
"EC:3.4.23.4",
"EC:3.4.23.43",
"EC:3.4.23.49",
"EC:3.4.23.5",
"MetaCyc:3.4.23.1-RXN",
"MetaCyc:3.4.23.15-RXN",
"MetaCyc:3.4.23.20-RXN",
"MetaC... | [
"GO:0004175",
"GO:0070001"
] | [] | [] | [] | [
"GO:0004175",
"GO:0070001"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.4.23.-",
"skos:narrowMatch EC:3.4.23.1",
"skos:narrowMatch EC:3.4.23.15",
"skos:narrowMatch EC:3.4.23.20",
"skos:narrowMatch EC:3.4.23.25",
"skos:narrowMatch EC:3.4.23.32",
"skos:narrowMatch EC:3.4.23.34",
"skos:narrowMatch EC:3.4.23.35",
"skos:narrowMatch EC:3.4.23.36",
"sko... | null | null | false | true | 3 |
GO:0004191 | 4,191 | obsolete barrierpepsin activity | molecular_function | OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor. | [
"EC:3.4.23.35"
] | This term was made obsolete because it represents a gene product. | [
"Bar proteinase activity",
"barrier proteinase activity",
"barrierpepsin activity",
"extracellular 'barrier' protein activity"
] | [
"NARROW",
"RELATED",
"EXACT",
"RELATED"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004190"
] | [] | [] | null | null | true | true | 6 |
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