LiteFold/GO · Datasets at Hugging Face

GO:0004193

4,193

obsolete cathepsin E activity

molecular_function

OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity.

[ "EC:3.4.23.34" ]

This term was made obsolete because it represents a gene product.

[ "cathepsin D-like acid proteinase activity", "cathepsin D-type proteinase activity", "cathepsin E activity", "cathepsin E-like acid proteinase activity", "EMAP", "erythrocyte membrane aspartic proteinase activity", "non-pepsin proteinase activity", "slow-moving proteinase activity", "SMP" ]

[ "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "NARROW", "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:0004190" ]

[]

null

true

7

GO:0004194

4,194

obsolete pepsin A activity

molecular_function

OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin.

[ "EC:3.4.23.1" ]

This term was made obsolete because it represents a gene product.

[ "elixir lactate of pepsin", "fundus-pepsin", "lactated pepsin", "lactated pepsin elixir", "P I", "P II", "pepsin A activity", "pepsin activity", "pepsin D", "pepsin fortior", "pepsin R" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "BROAD", "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:0004190" ]

[]

null

true

8

GO:0004195

4,195

obsolete renin activity

molecular_function

OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I.

[ "EC:3.4.23.15" ]

This term was made obsolete because it represents a gene product.

[ "angiotensin-forming enzyme activity", "angiotensinogenase activity", "renin activity" ]

[ "RELATED", "RELATED", "EXACT" ]

[]

[ "GO:0004190" ]

[]

null

true

6

GO:0004196

4,196

obsolete saccharopepsin activity

molecular_function

OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24.

[ "EC:3.4.23.25" ]

This term was made obsolete because it represents a gene product.

[ "aspartic proteinase yscA", "PRA", "proteinase A", "proteinase yscA", "Saccharomyces aspartic proteinase activity", "saccharomyces aspartic proteinase activity", "saccharomyces cerevisiae aspartic proteinase A", "saccharopepsin activity", "yeast endopeptidase A activity", "yeast proteinase A" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "NARROW", "RELATED", "RELATED", "EXACT", "NARROW", "RELATED" ]

[]

[ "GO:0004190" ]

[]

null

true

1

GO:0004197

4,197

cysteine-type endopeptidase activity

molecular_function

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.

[ "GOC:mah", "https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE", "https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE" ]

null

[ "caspase activity", "lysosomal cysteine-type endopeptidase", "metacaspase activity", "thiol endopeptidase activity" ]

[ "NARROW", "NARROW", "NARROW", "EXACT" ]

[]

[ "EC:3.4.22.-", "EC:3.4.22.1", "EC:3.4.22.14", "EC:3.4.22.15", "EC:3.4.22.16", "EC:3.4.22.27", "EC:3.4.22.28", "EC:3.4.22.34", "EC:3.4.22.38", "EC:3.4.22.40", "EC:3.4.22.41", "EC:3.4.22.8", "MetaCyc:3.4.22.1-RXN", "MetaCyc:3.4.22.14-RXN", "MetaCyc:3.4.22.15-RXN", "MetaCyc:3.4.22.16-RXN"...

[ "GO:0004175", "GO:0008234" ]

[]

[ "GO:0004175", "GO:0008234" ]

[]

[ "skos:exactMatch EC:3.4.22.-", "skos:narrowMatch EC:3.4.22.1", "skos:narrowMatch EC:3.4.22.14", "skos:narrowMatch EC:3.4.22.15", "skos:narrowMatch EC:3.4.22.16", "skos:narrowMatch EC:3.4.22.27", "skos:narrowMatch EC:3.4.22.28", "skos:narrowMatch EC:3.4.22.34", "skos:narrowMatch EC:3.4.22.38", "sko...

null

false

true

1

GO:0004198

4,198

calcium-dependent cysteine-type endopeptidase activity

molecular_function

Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.

[ "GOC:mah" ]

null

[ "calpain activity" ]

[ "NARROW" ]

[]

[ "EC:3.4.22.52", "EC:3.4.22.53", "EC:3.4.22.54", "Reactome:R-HSA-8848658 \"CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins\"", "Reactome:R-HSA-8863012 \"Calpain cleaves p35 to p25\"", "Reactome:R-HSA-9855106 \"Calpain2 (m-Calpain) cleaves TLN1 (Talin-1)\"", "Reactome:R-HSA-9861485 \"Calpain2 (m-Calpain, C...

[ "GO:0004197" ]

[]

[ "GO:0004197" ]

[]

[ "skos:narrowMatch EC:3.4.22.52", "skos:narrowMatch EC:3.4.22.53", "skos:narrowMatch EC:3.4.22.54", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29635\" xsd:anyURI" ]

null

false

true

3

GO:0004200

4,200

obsolete signaling (initiator) caspase activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it includes biological process information.

[ "signaling (initiator) caspase activity", "signalling (initiator) caspase activity" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0004197" ]

[]

null

true

9

GO:0004201

4,201

obsolete caspase-1 activity

molecular_function

OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this function can also hydrolyze the terminal bond in the small-molecule substrate, Ac-Tyr-Val-Ala-Asp-NHMec.

[ "EC:3.4.22.36" ]

This term was made obsolete because it represents a gene product.

[ "caspase-1 activity", "ICE" ]

[ "EXACT", "BROAD" ]

[]

[ "GO:0004197" ]

[]

null

true

6

GO:0004202

4,202

obsolete caspase-2 activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it represents a gene product.

[ "caspase-2 activity" ]

[ "EXACT" ]

[]

[ "GO:0004197" ]

[]

null

true

6

GO:0004203

4,203

obsolete caspase-4 activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it represents a gene product.

[ "caspase-4 activity" ]

[ "EXACT" ]

[]

[ "GO:0004197" ]

[]

null

true

9

GO:0004205

4,205

obsolete caspase-8 activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it represents a gene product.

[ "caspase-8 activity" ]

[ "EXACT" ]

[]

[ "GO:0004197" ]

[]

null

true

3

GO:0004206

4,206

obsolete caspase-10 activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it represents a gene product.

[ "caspase-10 activity" ]

[ "EXACT" ]

[]

[ "GO:0004197" ]

[]

null

true

7

GO:0004207

4,207

obsolete effector caspase activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it includes biological process information.

[ "effector caspase activity" ]

[ "EXACT" ]

[]

[ "GO:0004197" ]

[]

null

true

6

GO:0004208

4,208

obsolete caspase-3 activity

molecular_function

OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis.

[ "ISBN:0120793709" ]

This term was made obsolete because it represents a gene product.

[ "caspase-3 activity" ]

[ "EXACT" ]

[]

[ "GO:0004197" ]

[]

null

true

1

GO:0004209

4,209

obsolete caspase-6 activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it represents a gene product.

[ "caspase-6 activity" ]

[ "EXACT" ]

[]

[ "GO:0004197" ]

[]

null

true

3

GO:0004210

4,210

obsolete caspase-7 activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it represents a gene product.

[ "caspase-7 activity" ]

[ "EXACT" ]

[]

[ "GO:0004197" ]

[]

null

true

6

GO:0004211

4,211

obsolete caspase-9 activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it represents a gene product.

[ "caspase-9 activity" ]

[ "EXACT" ]

[]

[ "GO:0004197" ]

[]

null

true

8

GO:0004212

4,212

obsolete lysosomal cysteine-type endopeptidase

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it contains both component and function information.

[ "lysosomal cysteine-type endopeptidase" ]

[ "EXACT" ]

[]

[ "GO:0004197", "GO:0005764" ]

[]

null

true

7

GO:0004213

4,213

obsolete cathepsin B activity

molecular_function

OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.

[ "EC:3.4.22.1" ]

This term was made obsolete because it represents a gene product.

[ "cathepsin B activity", "cathepsin B1 activity", "cathepsin II" ]

[ "EXACT", "RELATED", "RELATED" ]

[]

[ "GO:0004197" ]

[]

null

true

2

GO:0004214

4,214

obsolete dipeptidyl-peptidase I activity

molecular_function

OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "dipeptidyl-peptidase I activity" ]

[ "EXACT" ]

[]

[ "GO:0008234", "GO:0008239" ]

[]

null

true

4

GO:0004215

4,215

obsolete cathepsin H activity

molecular_function

OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase.

[ "EC:3.4.22.16" ]

This term was made obsolete because it represents a gene product.

[ "aleurain activity", "benzoylarginine-naphthylamide (BANA) hydrolase activity", "cathepsin B3 activity", "cathepsin Ba", "cathepsin BA activity", "cathepsin H activity", "N-benzoylarginine-beta-naphthylamide hydrolase activity" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED" ]

[]

[ "GO:0004197" ]

[]

null

true

7

GO:0004216

4,216

obsolete cathepsin K activity

molecular_function

OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

[ "EC:3.4.22.38" ]

This term was made obsolete because it represents a gene product.

[ "cathepsin K activity", "cathepsin O activity", "cathepsin O2 activity", "cathepsin X activity" ]

[ "EXACT", "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:0004197" ]

[]

null

true

7

GO:0004217

4,217

obsolete cathepsin L activity

molecular_function

OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

[ "EC:3.4.22.15" ]

This term was made obsolete because it represents a gene product.

[ "Aldrichina grahami cysteine proteinase", "cathepsin L activity" ]

[ "NARROW", "EXACT" ]

[]

[ "GO:0004197" ]

[]

null

true

9

GO:0004218

4,218

obsolete cathepsin S activity

molecular_function

OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds.

[ "EC:3.4.22.27" ]

This term was made obsolete because it represents a gene product.

[ "cathepsin S activity" ]

[ "EXACT" ]

[]

[ "GO:0004197" ]

[]

null

true

7

GO:0004219

4,219

obsolete pyroglutamyl-peptidase I activity

molecular_function

OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "pyroglutamyl-peptidase I activity" ]

[ "EXACT" ]

[]

[ "GO:0008234", "GO:0016920" ]

[]

null

true

2

GO:0004221

4,221

obsolete ubiquitin thiolesterase activity

molecular_function

OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.

[ "EC:3.1.2.15", "GOC:jh2" ]

This term was made obsolete because this molecular function does not exist.

[ "ubiquitin C-terminal hydrolase activity", "ubiquitin carboxy-terminal esterase activity", "ubiquitin carboxy-terminal hydrolase activity", "ubiquitin thioesterase activity", "ubiquitin thiolesterase activity", "ubiquitin-C-terminal-thioester hydrolase activity", "ubiquitinyl hydrolase 1 activity" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "NARROW" ]

[ "GO:0008577" ]

[]

[ "GO:0004843" ]

[]

null

true

2

GO:0004222

4,222

metalloendopeptidase activity

molecular_function

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

[ "GOC:mah", "https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE", "https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE" ]

null

[ "metalloendoprotease activity", "metalloendoproteinase activity" ]

[ "NARROW", "NARROW" ]

[]

[ "EC:3.4.24.-", "EC:3.4.24.11", "EC:3.4.24.14", "EC:3.4.24.17", "EC:3.4.24.18", "EC:3.4.24.19", "EC:3.4.24.21", "EC:3.4.24.22", "EC:3.4.24.23", "EC:3.4.24.24", "EC:3.4.24.3", "EC:3.4.24.34", "EC:3.4.24.35", "EC:3.4.24.37", "EC:3.4.24.55", "EC:3.4.24.56", "EC:3.4.24.57", "EC:3.4.24.5...

[ "GO:0004175", "GO:0008237" ]

[]

[ "GO:0004175", "GO:0008237" ]

[]

[ "skos:exactMatch EC:3.4.24.-", "skos:narrowMatch EC:3.4.24.11", "skos:narrowMatch EC:3.4.24.14", "skos:narrowMatch EC:3.4.24.17", "skos:narrowMatch EC:3.4.24.18", "skos:narrowMatch EC:3.4.24.19", "skos:narrowMatch EC:3.4.24.21", "skos:narrowMatch EC:3.4.24.22", "skos:narrowMatch EC:3.4.24.23", "sk...

null

false

true

8

GO:0004226

4,226

obsolete Gly-X carboxypeptidase activity

molecular_function

OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa.

[ "EC:3.4.17.4" ]

This term was made obsolete because it represents a gene product.

[ "carboxypeptidase a", "carboxypeptidase S activity", "Gly-X carboxypeptidase activity", "Gly-Xaa carboxypeptidase activity", "glycine carboxypeptidase activity", "peptidase alpha", "yeast carboxypeptidase activity" ]

[ "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:0004181" ]

[]

null

true

2

GO:0004228

4,228

obsolete gelatinase A activity

molecular_function

OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "3/4 collagenase activity", "72 kDa gelatinase type A", "72-kDa gelatinase activity", "collagenase IV", "collagenase type IV", "gelatinase A activity", "matrix metalloproteinase 2 activity", "matrix metalloproteinase 5", "MMP 2", "MMP-2", "type IV collagen metalloproteinase", "type IV collagen...

[ "RELATED", "RELATED", "NARROW", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "EXACT", "BROAD", "RELATED", "RELATED" ]

[]

[ "GO:0004222" ]

[]

null

true

6

GO:0004229

4,229

obsolete gelatinase B activity

molecular_function

OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "92-kDa gelatinase activity", "92-kDa type IV collagenase activity", "95 kDa type IV collagenase/gelatinase activity", "collagenase IV", "collagenase type IV", "gelatinase B activity", "gelatinase MMP 9", "macrophage gelatinase activity", "matrix metalloproteinase 9 activity", "MMP 9", "MMP-9", ...

[ "NARROW", "NARROW", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "NARROW", "RELATED", "RELATED", "EXACT", "BROAD", "RELATED" ]

[]

[ "GO:0004222" ]

[]

null

true

1

GO:0004230

4,230

glutamyl aminopeptidase activity

molecular_function

Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide.

[ "EC:3.4.11.7" ]

null

[ "aminopeptidase A", "angiotensinase A", "angiotensinase A2", "antigen BP-1/6C3 of mouse B lymphocytes", "aspartate aminopeptidase activity", "Ca2+-activated glutamate aminopeptidase activity", "glutamyl peptidase activity", "L-aspartate aminopeptidase activity", "membrane aminopeptidase II" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:3.4.11.7", "MetaCyc:3.4.11.7-RXN" ]

[ "GO:0004177" ]

[]

[ "GO:0004177" ]

[]

[ "skos:exactMatch EC:3.4.11.7", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28557\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

1

GO:0004231

4,231

obsolete insulysin activity

molecular_function

OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "IDE", "insulin protease activity", "insulin proteinase activity", "insulin-degrading enzyme activity", "insulin-degrading neutral proteinase activity", "insulin-glucagon protease activity", "insulin-specific protease activity", "insulinase activity", "insulysin activity", "metalloinsulinase activ...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED" ]

[]

[ "GO:0004222" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/789\" xsd:anyURI" ]

null

true

2

GO:0004232

4,232

obsolete interstitial collagenase activity

molecular_function

OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hyd...

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "interstitial collagenase activity", "matrix metalloproteinase 1", "MMP-1", "vertebrate collagenase activity" ]

[ "EXACT", "EXACT", "EXACT", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

6

GO:0004234

4,234

obsolete macrophage elastase activity

molecular_function

OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "macrophage elastase activity", "metalloesterase activity", "MMP-12" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0004175", "GO:0004222" ]

[]

null

true

3

GO:0004235

4,235

obsolete matrilysin activity

molecular_function

OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "matrilysin activity", "matrin activity", "matrix metalloproteinase 7 activity", "matrix metalloproteinase pump 1", "metalloproteinase pump-1", "MMP", "MMP 7", "MMP-7", "PUMP", "PUMP-1 activity", "PUMP-1 proteinase activity", "putative (or punctuated) metalloproteinase-1 activity", "putative...

[ "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "NARROW", "RELATED", "NARROW", "RELATED", "NARROW" ]

[]

[ "GO:0004222" ]

[]

null

true

6

GO:0004237

4,237

obsolete membrane dipeptidase activity

molecular_function

OBSOLETE. Catalysis of the hydrolysis of dipeptides.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "membrane dipeptidase activity" ]

[ "EXACT" ]

[]

[ "GO:0016805" ]

[]

null

true

9

GO:0004238

4,238

obsolete meprin A activity

molecular_function

OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "endopeptidase-2 activity", "meprin", "meprin A activity", "meprin-a", "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase activity", "PABA-peptide hydrolase activity", "PPH" ]

[ "BROAD", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:0004222" ]

[]

null

true

4

GO:0004239

4,239

initiator methionyl aminopeptidase activity

molecular_function

Catalysis of the release of N-terminal initiator methionine from peptides.

[ "EC:3.4.11.18" ]

This term was reinstated from obsolete

[ "L-methionine aminopeptidase activity", "MAP", "methionine aminopeptidase activity", "peptidase M activity" ]

[ "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:3.4.11.18", "MetaCyc:3.4.11.18-RXN" ]

[ "GO:0004177" ]

[]

[ "GO:0004177" ]

[]

[ "skos:exactMatch EC:3.4.11.18", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22698\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

1

GO:0004240

4,240

obsolete mitochondrial processing peptidase activity

molecular_function

OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "alpha-mitochondrial processing peptidase", "beta-mitochondrial processing peptidase", "matrix peptidase", "matrix processing peptidase", "matrix processing proteinase", "mitochondrial processing peptidase activity", "mitochondrial protein precursor-processing proteinase activity", "MPP", "processin...

[ "NARROW", "NARROW", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "EXACT", "RELATED", "NARROW" ]

[]

[ "GO:0004222" ]

[]

null

true

5

GO:0004241

4,241

obsolete alpha-mitochondrial processing peptidase

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it represents a gene product.

[ "alpha-mitochondrial processing peptidase", "alpha-MPP" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0004222", "GO:0005739" ]

[]

null

true

8

GO:0004242

4,242

obsolete beta-mitochondrial processing peptidase

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it represents a gene product.

[ "beta-mitochondrial processing peptidase", "beta-MPP" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0004222", "GO:0005739" ]

[]

null

true

1

GO:0004243

4,243

obsolete mitochondrial intermediate peptidase activity

molecular_function

OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "MIP", "mitochondrial intermediate peptidase activity", "mitochondrial intermediate precursor-processing proteinase activity" ]

[ "BROAD", "EXACT", "RELATED" ]

[]

[ "GO:0004222" ]

[]

null

true

2

GO:0004244

4,244

obsolete mitochondrial inner membrane peptidase activity

molecular_function

OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space.

[ "PMID:12191769" ]

This term was made obsolete because it represents a gene product.

[ "IMP", "mitochondrial inner membrane peptidase activity" ]

[ "BROAD", "EXACT" ]

[]

[ "GO:0004175" ]

[]

null

true

4

GO:0004246

4,246

obsolete peptidyl-dipeptidase A activity

molecular_function

OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "ACE activity", "peptidyl-dipeptidase A activity" ]

[ "BROAD", "EXACT" ]

[]

[ "GO:0008241" ]

[]

null

true

4

GO:0004247

4,247

obsolete saccharolysin activity

molecular_function

OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "oligopeptidase yscD activity", "proteinase yscD activity", "saccharolysin activity", "saccharomyces cerevisiae proteinase yscD", "yeast cysteine proteinase D activity" ]

[ "NARROW", "NARROW", "EXACT", "RELATED", "NARROW" ]

[]

[ "GO:0004222" ]

[]

null

true

8

GO:0004248

4,248

obsolete stromelysin 1 activity

molecular_function

OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "collagen-activating protein", "collagenase activating protein", "matrix metalloproteinase 3 activity", "MMP-3", "neutral proteoglycanase activity", "procollagenase activator", "proteoglycanase activity", "stromelysin", "stromelysin 1 activity", "transin activity" ]

[ "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED" ]

[]

[ "GO:0004222" ]

[]

null

true

2

GO:0004249

4,249

obsolete stromelysin 3 activity

molecular_function

OBSOLETE. Was not defined before being made obsolete.

[ "GOC:mah" ]

This term was made obsolete because it represents a gene product.

[ "matrix metalloproteinase 11", "MMP-11", "stromelysin 3 activity" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0004222" ]

[]

null

true

3

GO:0004250

4,250

obsolete aminopeptidase I activity

molecular_function

OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "aminopeptidase I activity" ]

[ "EXACT" ]

[]

[ "GO:0004177", "GO:0008235" ]

[]

null

true

4

GO:0004251

4,251

obsolete X-Pro dipeptidase activity

molecular_function

OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "X-Pro dipeptidase activity", "Xaa-Pro dipeptidase activity" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0008235", "GO:0016805" ]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28173\" xsd:anyURI" ]

null

true

4

GO:0004252

4,252

serine-type endopeptidase activity

molecular_function

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

[ "GOC:mah", "https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE" ]

null

[ "blood coagulation factor activity", "serine elastase activity" ]

[ "RELATED", "RELATED" ]

[]

[ "goslim_chembl" ]

[ "EC:3.4.21.-", "EC:3.4.21.1", "EC:3.4.21.10", "EC:3.4.21.102", "EC:3.4.21.20", "EC:3.4.21.21", "EC:3.4.21.22", "EC:3.4.21.26", "EC:3.4.21.27", "EC:3.4.21.34", "EC:3.4.21.35", "EC:3.4.21.36", "EC:3.4.21.38", "EC:3.4.21.39", "EC:3.4.21.4", "EC:3.4.21.41", "EC:3.4.21.42", "EC:3.4.21.4...

[ "GO:0004175", "GO:0008236" ]

[]

[ "GO:0004175", "GO:0008236" ]

[]

[ "skos:exactMatch EC:3.4.21.-", "skos:narrowMatch EC:3.4.21.1", "skos:narrowMatch EC:3.4.21.10", "skos:narrowMatch EC:3.4.21.102", "skos:narrowMatch EC:3.4.21.20", "skos:narrowMatch EC:3.4.21.21", "skos:narrowMatch EC:3.4.21.22", "skos:narrowMatch EC:3.4.21.26", "skos:narrowMatch EC:3.4.21.27", "sk...

null

false

true

5

GO:0004253

4,253

obsolete gamma-renin activity

molecular_function

OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "gamma-renin activity" ]

[ "EXACT" ]

[]

[ "GO:0004252" ]

[]

null

true

4

GO:0004254

4,254

obsolete acylaminoacyl-peptidase activity

molecular_function

OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide.

[ "GOC:curators" ]

null

[ "acylamino-acid-releasing enzyme activity", "acylaminoacyl-peptidase activity", "N-acylpeptide hydrolase activity", "N-formylmethionine (fMet) aminopeptidase activity" ]

[ "RELATED", "EXACT", "RELATED", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

3

GO:0004258

4,258

obsolete vacuolar carboxypeptidase Y

molecular_function

OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity.

[ "EC:3.4.16.5" ]

This term was made obsolete because it contains both component and function information.

[ "vacuolar carboxypeptidase Y" ]

[ "EXACT" ]

[]

[ "GO:0004185", "GO:0005773" ]

[]

null

true

1

GO:0004261

4,261

obsolete cathepsin G activity

molecular_function

OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "cathepsin G activity", "chymotrypsin-like proteinase activity", "neutral proteinase activity" ]

[ "EXACT", "RELATED", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

9

GO:0004262

4,262

obsolete cerevisin activity

molecular_function

OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "baker's yeast proteinase B", "brewer's yeast proteinase", "cerevisin activity", "peptidase beta", "proteinase yscB activity", "yeast proteinase B activity" ]

[ "RELATED", "NARROW", "EXACT", "RELATED", "NARROW", "NARROW" ]

[]

[ "GO:0004252" ]

[]

null

true

6

GO:0004263

4,263

obsolete chymotrypsin activity

molecular_function

OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa.

[ "ISBN:0198506732" ]

This term was made obsolete because it represents a gene product.

[ "alpha-chymar", "alpha-chymar ophth", "alpha-chymotrypsin A", "alpha-chymotrypsin activity", "avazyme", "chymar", "chymotest", "chymotrypsin A activity", "chymotrypsin activity", "chymotrypsin B activity", "chymotrypsins A and B", "enzeon", "quimar", "quimotrase activity" ]

[ "RELATED", "RELATED", "RELATED", "NARROW", "RELATED", "RELATED", "RELATED", "NARROW", "EXACT", "NARROW", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

6

GO:0004274

4,274

obsolete dipeptidyl-peptidase IV activity

molecular_function

OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "dipeptidyl-peptidase IV activity" ]

[ "EXACT" ]

[]

[ "GO:0008236", "GO:0008239" ]

[]

null

true

8

GO:0004275

4,275

obsolete enteropeptidase activity

molecular_function

OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "enterokinase activity", "enteropeptidase activity" ]

[ "RELATED", "EXACT" ]

[]

[ "GO:0004252" ]

[]

null

true

9

GO:0004276

4,276

obsolete furin activity

molecular_function

OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "dibasic processing enzyme activity", "furin activity", "PACE", "paired basic amino acid cleaving enzyme", "paired basic amino acid converting enzyme", "paired basic amino acid residue cleaving enzyme activity", "prohormone convertase activity", "serine proteinase PACE", "SPC3" ]

[ "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "NARROW", "RELATED", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

2

GO:0004277

4,277

obsolete granzyme A activity

molecular_function

OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "CTLA3", "cytotoxic T lymphocyte serine protease", "cytotoxic T-lymphocyte proteinase 1 activity", "granzyme A activity", "HuTPS", "T-cell associated protease 1", "T-cell derived serine proteinase", "TSP-1" ]

[ "RELATED", "NARROW", "NARROW", "EXACT", "RELATED", "RELATED", "NARROW", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

4

GO:0004278

4,278

obsolete granzyme B activity

molecular_function

OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "CCP1 proteinase", "CCPII", "CTLA1", "cytotoxic cell proteinase-1", "cytotoxic t-lymphocyte proteinase 2 activity", "granzyme B activity", "granzyme G", "granzyme H" ]

[ "NARROW", "RELATED", "RELATED", "RELATED", "NARROW", "EXACT", "RELATED", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

8

GO:0004281

4,281

obsolete pancreatic elastase II activity

molecular_function

OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "pancreatic elastase 2", "pancreatic elastase II activity" ]

[ "RELATED", "EXACT" ]

[]

[ "GO:0004252" ]

[]

null

true

9

GO:0004283

4,283

obsolete plasmin activity

molecular_function

OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "actase activity", "fibrinase activity", "fibrinolysin activity", "plasmin activity", "serum tryptase activity", "thrombolysin" ]

[ "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

2

GO:0004284

4,284

obsolete acrosin activity

molecular_function

OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "acrosin activity", "acrosin amidase activity", "acrosomal protease activity", "acrosomal proteinase activity", "acrozonase activity", "alpha-acrosin", "beta-acrosin", "psi-acrosin" ]

[ "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

9

GO:0004285

4,285

obsolete proprotein convertase 1 activity

molecular_function

OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "NEC 1 activity", "neuroendocrine convertase 1 activity", "PC1 activity", "prohormone convertase 3", "prohormone convertase I activity", "proprotein convertase 1 activity" ]

[ "NARROW", "NARROW", "NARROW", "RELATED", "NARROW", "EXACT" ]

[]

[ "GO:0004252" ]

[]

null

true

7

GO:0004286

4,286

obsolete proprotein convertase 2 activity

molecular_function

OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "NEC 2 activity", "neuroendocrine convertase 2 activity", "PC2 activity", "prohormone convertase II activity", "proprotein convertase 2 activity" ]

[ "NARROW", "NARROW", "NARROW", "NARROW", "EXACT" ]

[]

[ "GO:0004252" ]

[]

null

true

2

GO:0004287

4,287

obsolete prolyl oligopeptidase activity

molecular_function

OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "endoprolylpeptidase activity", "post-proline cleaving enzyme activity", "post-proline endopeptidase activity", "proline endopeptidase activity", "proline-specific endopeptidase activity", "prolyl endopeptidase activity", "prolyl oligopeptidase activity" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT" ]

[]

[ "GO:0004252" ]

[]

null

true

7

GO:0004289

4,289

obsolete subtilase activity

molecular_function

OBSOLETE. Was not defined before being made obsolete.

[ "GOC:mah" ]

This term was made obsolete because it represents a gene product.

[ "subtilase activity" ]

[ "EXACT" ]

[]

[ "GO:0004252" ]

[]

null

true

6

GO:0004290

4,290

obsolete kexin activity

molecular_function

OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "andrenorphin-Gly-generating enzyme", "endoproteinase Kex2p", "gene KEX2 dibasic proteinase", "Kex 2p proteinase", "Kex2 endopeptidase", "Kex2 endoprotease", "Kex2 endoproteinase", "Kex2 protease", "Kex2 proteinase", "Kex2-like endoproteinase", "Kex2-like precursor protein processing endoproteas...

[ "RELATED", "RELATED", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "EXACT", "RELATED", "RELATED", "NARROW", "RELATED", "RELATED", "RELATED", "NARROW", "RELATED", "NARROW" ]

[]

[ "GO:0004252" ]

[]

null

true

7

GO:0004293

4,293

obsolete tissue kallikrein activity

molecular_function

OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at t...

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "bradykininogenase", "callicrein", "depot-padutin", "dilminal D", "glandular kallikrein activity", "glumorin", "kallidinogenase", "kidney kallikrein", "kininogenase", "kininogenin activity", "onokrein P", "padreatin", "padutin", "pancreatic kallikrein", "salivary kallikrein", "submandi...

[ "BROAD", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "BROAD", "RELATED", "BROAD", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED" ]

[ "GO:0004279" ]

[]

[ "GO:0004252" ]

[]

null

true

3

GO:0004294

4,294

obsolete tripeptidyl-peptidase II activity

molecular_function

OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "tripeptidyl-peptidase II activity" ]

[ "EXACT" ]

[]

[ "GO:0008240" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28173\" xsd:anyURI" ]

null

true

7

GO:0004295

4,295

obsolete trypsin activity

molecular_function

OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "alpha-trypsin activity", "beta-trypsin activity", "cocoonase activity", "parenzyme", "parenzymol", "pseudotrypsin", "sperm receptor hydrolase activity", "tripcellim", "trypsin activity", "tryptar", "trypure" ]

[ "NARROW", "NARROW", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

6

GO:0004298

4,298

threonine-type endopeptidase activity

molecular_function

Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.

[ "GOC:mah", "https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE", "https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE" ]

null

[ "26S protease", "alkaline protease", "ingensin", "large multicatalytic protease", "lens neutral proteinase", "MCP", "multicatalytic endopeptidase complex", "multicatalytic proteinase", "multicatalytic proteinase (complex)", "prosome", "proteasome endopeptidase complex", "threonine endopeptidas...

[ "RELATED", "RELATED", "RELATED", "NARROW", "NARROW", "RELATED", "RELATED", "NARROW", "NARROW", "RELATED", "NARROW", "EXACT", "NARROW", "NARROW" ]

[]

[ "EC:3.4.25.-", "Reactome:R-HSA-9818574 \"TASP1 cleaves KMT2A\"", "Reactome:R-HSA-9818577 \"TASP1 cleaves KMT2B\"" ]

[ "GO:0004175", "GO:0070003" ]

[]

[ "GO:0004175", "GO:0070003" ]

[]

[ "skos:exactMatch EC:3.4.25.-", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

3

GO:0004299

4,299

obsolete proteasome endopeptidase activity

molecular_function

OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity.

[ "EC:3.4.25.1" ]

This term was made obsolete because it mentions a component term in the text string.

[ "multicatalytic endopeptidase", "proteasome", "proteasome endopeptidase activity", "proteasome endopeptidase complex" ]

[ "RELATED", "RELATED", "EXACT", "RELATED" ]

[]

[ "GO:0004175", "GO:0008233" ]

[]

null

true

4

GO:0004300

4,300

enoyl-CoA hydratase activity

molecular_function

Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3...

[ "EC:4.2.1.17" ]

null

[ "(3S)-3-hydroxyacyl-CoA hydro-lyase activity", "2-enoyl-CoA hydratase activity", "2-octenoyl coenzyme A hydrase activity", "3-hydroxy-fatty acyl-CoA dehydratase", "3-hydroxyacyl-CoA dehydratase", "acyl coenzyme A hydrase activity", "beta-hydroxyacid dehydrase activity", "beta-hydroxyacyl-CoA dehydrase...

[ "RELATED", "RELATED", "RELATED", "EXACT", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED" ]

[ "GO:0016510" ]

[]

[ "EC:4.2.1.17", "Reactome:R-HSA-70830 \"tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA\"", "Reactome:R-HSA-70870 \"ECHS1 hydrates methacrylyl-CoA\"", "Reactome:R-HSA-77256 \"2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA\"", "Reactome:R-HSA-77277 \"trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-...

[ "GO:0016836" ]

[]

[ "GO:0016836" ]

[]

[ "skos:exactMatch EC:4.2.1.17", "skos:narrowMatch RHEA:20724", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29788\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

1

GO:0004303

4,303

estradiol 17-beta-dehydrogenase [NAD(P)+] activity

molecular_function

Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor.

[ "EC:1.1.1.62" ]

null

[ "17-beta-estradiol dehydrogenase activity", "17-beta-HSD activity", "17-beta-hydroxysteroid dehydrogenase activity", "17beta,20alpha-hydroxysteroid dehydrogenase activity", "17beta-estradiol dehydrogenase activity", "17beta-HSD", "17beta-hydroxysteroid dehydrogenase activity", "20alpha-hydroxysteroid ...

[ "RELATED", "BROAD", "BROAD", "RELATED", "RELATED", "RELATED", "RELATED", "BROAD", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:1.1.1.62", "MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN", "Reactome:R-HSA-5693390 \"HSD17B11 dehydrogenates EST17b to E1\"", "Reactome:R-HSA-5696822 \"AKR1B15 reduces EST17b to E1\"", "Reactome:R-HSA-6810594 \"HSD17B14 tetramer oxidises estradiol (EST17b) to estrone (E1)\"", "Reactome:R-HSA-804969 \"H...

[ "GO:0033764" ]

[]

[ "GO:0033764" ]

[]

[ "skos:exactMatch EC:1.1.1.62", "skos:narrowMatch RHEA:24612", "skos:narrowMatch RHEA:24616", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19811\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21791\" xsd:anyURI", "term_tracker_item \"https:...

null

false

true

5

GO:0004304

4,304

estrone sulfotransferase activity

molecular_function

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate.

[ "EC:2.8.2.4" ]

null

[ "3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity", "3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity", "3'-phosphoadenylylsulfate:oestrone sulfotransferase activity", "estrogen sulfotransferase", "estrogen sulphotransferase activity", "estrone sulphotransferase activity", "o...

[ "RELATED", "RELATED", "RELATED", "BROAD", "RELATED", "EXACT", "RELATED" ]

[]

[ "EC:2.8.2.4", "MetaCyc:ESTRONE-SULFOTRANSFERASE-RXN", "Reactome:R-HSA-176664 \"estrone + PAPS => estrone 3-sulfate + PAP\"", "RHEA:15973" ]

[ "GO:0008146" ]

[]

[ "GO:0008146" ]

[]

[ "skos:exactMatch EC:2.8.2.4", "skos:exactMatch RHEA:15973", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

9

GO:0004305

4,305

ethanolamine kinase activity

molecular_function

Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H+ + phosphoethanolamine.

[ "EC:2.7.1.82", "RHEA:13069" ]

null

[ "ATP:ethanolamine O-phosphotransferase activity", "ethanolamine kinase (phosphorylating)", "ethanolamine phosphokinase activity" ]

[ "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.7.1.82", "KEGG_REACTION:R01468", "MetaCyc:ETHANOLAMINE-KINASE-RXN", "Reactome:R-HSA-1483222 \"ETA is phosphorylated to PETA by CHK/ETNK\"", "RHEA:13069" ]

[ "GO:0016301", "GO:0016773" ]

[]

[ "GO:0016301", "GO:0016773" ]

[]

[ "skos:exactMatch EC:2.7.1.82", "skos:exactMatch RHEA:13069", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

2

GO:0004306

4,306

ethanolamine-phosphate cytidylyltransferase activity

molecular_function

Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine.

[ "EC:2.7.7.14" ]

null

[ "CTP-phosphoethanolamine cytidylyltransferase activity", "CTP:ethanolamine-phosphate cytidylyltransferase activity", "CTP:phosphoethanolamine cytidylyltransferase activity", "ET", "ethanolamine phosphate cytidylyltransferase activity", "phosphoethanolamine cytidylyltransferase activity", "phosphoryletha...

[ "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "EXACT", "BROAD" ]

[]

[ "EC:2.7.7.14", "MetaCyc:2.7.7.14-RXN", "Reactome:R-HSA-1483190 \"PETA and CTP are condensed to CDP-ETA by PCY2\"", "RHEA:24592" ]

[ "GO:0070567" ]

[]

[ "GO:0070567" ]

[]

[ "skos:exactMatch EC:2.7.7.14", "skos:exactMatch RHEA:24592", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

4

GO:0004307

4,307

ethanolaminephosphotransferase activity

molecular_function

Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine.

[ "EC:2.7.8.1", "RHEA:32943" ]

null

[ "CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity", "CDPethanolamine diglyceride phosphotransferase activity", "diacylglycerol ethanolaminephosphotransferase activity", "EPT", "phosphorylethanolamine-glyceride transferase activity" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.7.8.1", "MetaCyc:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN", "Reactome:R-HSA-1482962 \"CDP-ETA and DAG are converted to PE by CEPT1/EPT1\"", "RHEA:32943", "RHEA:54248", "RHEA:54252", "RHEA:54340", "RHEA:80247" ]

[ "GO:0017169" ]

[]

[ "GO:0017169" ]

[]

[ "skos:exactMatch EC:2.7.8.1", "skos:exactMatch RHEA:32943", "skos:narrowMatch RHEA:54248", "skos:narrowMatch RHEA:54252", "skos:narrowMatch RHEA:54340", "skos:narrowMatch RHEA:80247", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

7

GO:0004308

4,308

exo-alpha-sialidase activity

molecular_function

Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

[ "EC:3.2.1.18" ]

null

[ "acetylneuraminidase activity", "acetylneuraminyl hydrolase activity", "alpha-neuraminidase activity", "N-acylneuraminate glycohydrolase activity", "neuraminidase activity", "sialidase activity" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:3.2.1.18", "MetaCyc:3.2.1.18-RXN", "Reactome:R-HSA-1605723 \"NEU2 cleaves GM3 to form LacCer (cytosol)\"", "Reactome:R-HSA-1605724 \"NEU1,4 hydrolyze PSAP(195-273):GM3:PE\"", "Reactome:R-HSA-1605768 \"NEU3 cleaves GM3 to form LacCer (plasma membrane)\"", "Reactome:R-HSA-168870 \"Neuraminidase enzymati...

[ "GO:0016997" ]

[]

[ "GO:0016997" ]

[]

[ "skos:exactMatch EC:3.2.1.18", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

6

GO:0004309

4,309

exopolyphosphatase activity

molecular_function

Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate.

[ "EC:3.6.1.11" ]

null

[ "acid phosphoanhydride phosphohydrolase activity", "exopolypase activity", "Gra-Pase activity", "metaphosphatase activity", "polyphosphate phosphohydrolase activity" ]

[ "RELATED", "RELATED", "RELATED", "BROAD", "RELATED" ]

[]

[ "EC:3.6.1.11", "MetaCyc:EXOPOLYPHOSPHATASE-RXN", "RHEA:21528" ]

[ "GO:0016462" ]

[]

[ "GO:0016462" ]

[]

[ "skos:exactMatch EC:3.6.1.11", "skos:exactMatch RHEA:21528", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

2

GO:0004310

4,310

obsolete farnesyl-diphosphate farnesyltransferase activity

molecular_function

OBSOLETE. Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.

[ "GOC:curators" ]

This term was obsoleted because it represents a subreaction of squalene synthase activity ; GO:0051996.

[]

[ "GO:0051996" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28819\" xsd:anyURI" ]

null

true

5

GO:0004311

4,311

geranylgeranyl diphosphate synthase activity

molecular_function

Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate.

[ "RHEA:17653" ]

The catalyzed reaction forms (free) geranylgeranyl diphosphate. There is no relationship between this activity and protein farnesyltransferase activity, GO:0004660, where the catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein.

[ "farnesyltranstransferase activity", "geranylgeranyl pyrophosphate synthase activity", "geranylgeranyl pyrophosphate synthetase activity", "geranylgeranyl-diphosphate synthase activity", "geranylgeranyl-PP synthetase activity", "trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransfe...

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "RELATED" ]

[]

[ "EC:2.5.1.29", "KEGG_REACTION:R02061", "MetaCyc:FARNESYLTRANSTRANSFERASE-RXN", "RHEA:17653" ]

[ "GO:0120531" ]

[]

[ "GO:0120531" ]

[]

[ "skos:exactMatch EC:2.5.1.29", "skos:exactMatch RHEA:17653", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20661\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28430\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontol...

null

false

true

4

GO:0004312

4,312

fatty acid synthase activity

molecular_function

Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.

[ "EC:2.3.1.85" ]

null

[ "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)", "fatty-acid synthase activity" ]

[ "RELATED", "EXACT" ]

[]

[ "EC:2.3.1.85", "MetaCyc:FATTY-ACID-SYNTHASE-RXN", "Reactome:R-HSA-163756 \"Formation of fatty acid synthase (FAS) dimer\"", "Reactome:R-HSA-75872 \"Conversion of malonyl-CoA and acetyl-CoA to palmitate\"", "RHEA:14993" ]

[ "GO:0016747" ]

[]

[ "GO:0016747" ]

[]

[ "skos:exactMatch EC:2.3.1.85", "skos:exactMatch RHEA:14993", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

6

GO:0004313

4,313

[acyl-carrier-protein] S-acetyltransferase activity

molecular_function

Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein].

[ "RHEA:41788" ]

null

[ "[acyl-carrier protein] S-acetyltransferase activity", "ACAT activity", "acetyl coenzyme A-acyl-carrier-protein transacylase activity", "acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity", "ACP acetyltransferase activity", "ACP S-acetyltransferase activity", "ACPacetyltransferase activity", ...

[ "EXACT", "BROAD", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.3.1.38", "MetaCyc:ACP-S-ACETYLTRANSFER-RXN", "RHEA:41788" ]

[ "GO:0016418" ]

[]

[ "GO:0016418" ]

[]

[ "skos:exactMatch EC:2.3.1.38", "skos:exactMatch RHEA:41788", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

3

GO:0004314

4,314

[acyl-carrier-protein] S-malonyltransferase activity

molecular_function

Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein].

[ "EC:2.3.1.39" ]

null

[ "[acyl-carrier protein] S-malonyltransferase activity", "ACP S-malonyltransferase activity", "acyl carrier protein malonyltransferase activity", "acyl carrier proteinmalonyltransferase activity", "acyl-carrier-protein S-malonyltransferase activity", "FabD", "malonyl coenzyme A-acyl carrier protein trans...

[ "EXACT", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "BROAD", "BROAD", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.3.1.39", "MetaCyc:MALONYL-COA-ACP-TRANSACYL-RXN", "Reactome:R-HSA-8933547 \"MCAT transfers Mal from Mal-CoA to NDUFAB1\"" ]

[ "GO:0016419" ]

[]

[ "GO:0016419" ]

[]

[ "skos:exactMatch EC:2.3.1.39", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

1

GO:0004315

4,315

3-oxoacyl-[acyl-carrier-protein] synthase activity

molecular_function

Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein].

[ "RHEA:22836" ]

Note that this activity is responsible for the chain-elongation step of dissociated (type II) fatty-acid biosynthesis, i.e. the addition of two C atoms to the fatty-acid chain. Can use fatty acyl thioesters of ACP (C2 to C16) as substrates, as well as fatty acyl thioesters of Co-A (C4 to C16).

[ "3-ketoacyl-acyl carrier protein synthase activity", "3-oxoacyl-[acyl-carrier protein] synthase activity", "3-oxoacyl-ACP synthase activity", "3-oxoacyl-acyl carrier protein synthase I activity", "3-oxoacyl-acyl-carrier-protein synthase activity", "acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-...

[ "RELATED", "EXACT", "EXACT", "NARROW", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "NARROW", "NARROW", "RELATED", "RELATED", "RELATED", "NARROW", "NARROW", "RELATED", "BROAD", "BROAD", "EXACT" ]

[ "GO:0033817" ]

[]

[ "EC:2.3.1.179", "EC:2.3.1.41", "MetaCyc:2.3.1.179-RXN", "MetaCyc:3-OXOACYL-ACP-SYNTH-RXN", "RHEA:14565", "RHEA:22836", "RHEA:41800", "RHEA:41820", "RHEA:41836", "RHEA:41852", "RHEA:41868", "RHEA:41884", "RHEA:41900", "RHEA:41916", "RHEA:42248", "RHEA:42252", "RHEA:42260", "RHEA:422...

[ "GO:0016747" ]

[]

[ "GO:0016747" ]

[]

[ "skos:exactMatch EC:2.3.1.41", "skos:exactMatch MetaCyc:3-OXOACYL-ACP-SYNTH-RXN", "skos:exactMatch RHEA:22836", "skos:narrowMatch EC:2.3.1.179", "skos:narrowMatch MetaCyc:2.3.1.179-RXN", "skos:narrowMatch RHEA:14565", "skos:narrowMatch RHEA:41800", "skos:narrowMatch RHEA:41820", "skos:narrowMatch RH...

null

false

true

4

GO:0004316

4,316

3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity

molecular_function

Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+.

[ "RHEA:17397" ]

null

[ "(3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity", "3-ketoacyl acyl carrier protein reductase activity", "3-oxoacyl-[acyl-carrier protein] reductase activity", "3-oxoacyl-ACP reductase activity", "3-oxoacyl-ACPreductase activity", "3-oxoacyl-acyl-carrier-protein reductase activity", ...

[ "RELATED", "RELATED", "EXACT", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:1.1.1.100", "MetaCyc:3-OXOACYL-ACP-REDUCT-RXN", "MetaCyc:RXN-10659", "MetaCyc:RXN-11476", "MetaCyc:RXN-11480", "Reactome:R-HSA-8862152 \"2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP\"", "RHEA:17397" ]

[ "GO:0016616" ]

[]

[ "GO:0016616" ]

[]

[ "skos:exactMatch EC:1.1.1.100", "skos:exactMatch RHEA:17397", "skos:narrowMatch MetaCyc:RXN-10659", "skos:narrowMatch MetaCyc:RXN-11476", "skos:narrowMatch MetaCyc:RXN-11480", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21876\" xsd:anyURI" ]

null

false

true

3

GO:0004317

4,317

obsolete (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity

molecular_function

OBSOLETE. Catalysis of the reaction: (3R)-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O.

[ "PMID:8088535" ]

This term was obsoleted because it represents a specific substrate of (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity ; GO:0019171.

[ "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)", "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity", "(3R)-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity", "3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity",...

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0019171" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28163\" xsd:anyURI" ]

null

true

6

GO:0004318

4,318

enoyl-[acyl-carrier-protein] reductase (NADH) activity

molecular_function

Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NAD+ = a (2E)-enoyl-[ACP] + H+ + NADH.

[ "RHEA:10240" ]

null

[ "acyl-acyl-carrier-protein:NAD+ oxidoreductase", "enoyl-[acyl-carrier protein] reductase (NADH) activity", "enoyl-ACP reductase (NADH) activity", "enoyl-acyl-carrier-protein reductase (NADH)", "NADH-enoyl acyl carrier protein reductase activity", "NADH-specific enoyl-ACP reductase activity" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:1.3.1.9", "MetaCyc:ENOYL-ACP-REDUCT-NADH-RXN", "RHEA:10240" ]

[ "GO:0016631" ]

[]

[ "GO:0016631" ]

[]

[ "skos:exactMatch EC:1.3.1.9", "skos:exactMatch RHEA:10240", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25307\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

5

GO:0004319

4,319

obsolete enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity

molecular_function

OBSOLETE. Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+.

[ "EC:1.3.1.10" ]

This term was obsoleted because it captures the stereospecificity of the NADPH cofactor, which is outside the scope of GO. Consider annotating to enoyl-[acyl-carrier-protein] reductase (NADPH) activity ; GO:0141148.

[ "acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)", "enoyl acyl-carrier-protein reductase activity", "enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity", "enoyl-ACP reductase (NADPH, B-specific) activity", "enoyl-acyl-carrier-protein reductase (NADPH, B-specific)", "enoyl-acyl...

[ "RELATED", "RELATED", "EXACT", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:0141148" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25699\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28173\" xsd:anyURI" ]

null

true

1

GO:0004320

4,320

obsolete oleoyl-[acyl-carrier-protein] hydrolase activity

molecular_function

OBSOLETE. Catalysis of the reaction: (9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H+ + holo-[ACP].

[ "GOC:curators" ]

This term was obsoleted because it represents a specific substrate of fatty acyl-[ACP] hydrolase activity ; GO:0016297.

[ "oleoyl-[acyl-carrier protein] hydrolase activity", "oleoyl-ACP hydrolase activity", "oleoyl-ACP thioesterase activity", "oleoyl-acyl carrier protein thioesterase activity", "oleoyl-acyl-carrier-protein hydrolase" ]

[ "EXACT", "EXACT", "RELATED", "RELATED", "BROAD" ]

[]

[ "GO:0016297" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25677\" xsd:anyURI" ]

null

true

8

GO:0004321

4,321

fatty-acyl-CoA synthase activity

molecular_function

Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.

[ "EC:2.3.1.86" ]

null

[ "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)", "fatty acyl CoA synthase activity", "yeast fatty acid synthase activity" ]

[ "RELATED", "EXACT", "NARROW" ]

[]

[ "EC:2.3.1.86", "MetaCyc:FATTY-ACYL-COA-SYNTHASE-RXN", "RHEA:22896" ]

[ "GO:0016408" ]

[]

[ "GO:0016408" ]

[]

[ "skos:exactMatch EC:2.3.1.86", "skos:exactMatch RHEA:22896", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

7

GO:0004322

4,322

ferroxidase activity

molecular_function

Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

[ "RHEA:11148" ]

null

[ "caeruloplasmin", "ceruloplasmin", "Fe(II):oxygen oxidoreductase activity", "ferro:O2 oxidoreductase activity", "ferroxidase I", "ferroxidase, iron II:oxygen oxidoreductase activity", "HEPH", "hephaestin", "iron(II): oxygen oxidoreductase activity", "multicopper ferroxidase iron transport mediator...

[ "NARROW", "NARROW", "RELATED", "RELATED", "RELATED", "RELATED", "NARROW", "NARROW", "RELATED", "NARROW" ]

[]

[ "EC:1.16.3.1", "MetaCyc:RXN0-1483", "Reactome:R-HSA-1562603 \"BfrB stores iron\"", "Reactome:R-HSA-1562604 \"BfrA stores iron\"", "Reactome:R-HSA-1562626 \"Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)\"", "Reactome:R-HSA-5621402 \"Defective CP does not oxidise Fe2+ to Fe3+\"", "Reactome:R-HSA-5691107 ...

[ "GO:0016724" ]

[]

[ "GO:0016724" ]

[]

[ "skos:exactMatch EC:1.16.3.1", "skos:exactMatch RHEA:11148", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20675\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

5

GO:0004323

4,323

obsolete multicopper ferroxidase iron transport mediator activity

molecular_function

OBSOLETE. Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

[ "EC:1.16.3.1" ]

This term was made obsolete because it represents a multifunctional gene product.

[ "multicopper ferroxidase iron transport mediator activity" ]

[ "EXACT" ]

[]

[ "GO:0004322", "GO:0005381" ]

[]

null

true

5

GO:0004325

4,325

protoporphyrin ferrochelatase activity

molecular_function

Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX.

[ "RHEA:22584" ]

null

[ "ferro-protoporphyrin chelatase activity", "ferrochelatase activity", "heme synthase activity", "heme synthetase activity", "iron chelatase activity", "protoheme ferro-lyase (protoporphyrin-forming)", "protoheme ferro-lyase activity", "protoheme ferrolyase activity" ]

[ "EXACT", "BROAD", "BROAD", "BROAD", "BROAD", "EXACT", "EXACT", "EXACT" ]

[]

[ "EC:4.98.1.1", "KEGG_REACTION:R00310", "MetaCyc:PROTOHEMEFERROCHELAT-RXN", "Reactome:R-HSA-189465 \"FECH binds Fe2+ to PRIN9 to form heme\"", "RHEA:22584" ]

[ "GO:0016829" ]

[]

[ "GO:0016829" ]

[]

[ "skos:exactMatch EC:4.98.1.1", "skos:exactMatch RHEA:22584", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23371\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontol...

null

false

true

2

GO:0004326

4,326

tetrahydrofolylpolyglutamate synthase activity

molecular_function

Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).

[ "EC:6.3.2.17" ]

null

[ "folate polyglutamate synthetase activity", "folylpoly(gamma-glutamate) synthase activity", "folylpoly-gamma-glutamate synthase activity", "folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity", "folylpolyglutamate synthase activity", "folylpolyglutamate synthetase activity", "folylpol...

[ "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:6.3.2.17", "MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN", "Reactome:R-HSA-197958 \"FPGS-2 transforms THF to THFPG\"", "Reactome:R-HSA-200681 \"FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG\"", "Reactome:R-HSA-200682 \"Mitochondrial FPGS-1 transforms THF to THFPG\"", "RHEA:10580" ]

[ "GO:0016881" ]

[ "part_of GO:0046901" ]

[ "part_of" ]

[ "GO:0046901" ]

[ "GO:0016881", "GO:0046901" ]

[]

[ "skos:exactMatch EC:6.3.2.17", "skos:exactMatch RHEA:10580", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

4

GO:0004327

4,327

obsolete formaldehyde dehydrogenase (glutathione) activity

molecular_function

OBSOLETE. Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+.

[ "EC:1.2.1.1" ]

This term was made obsolete because it was derived from an EC entry (1.2.1.1) that has since been split into two entries.

[ "formaldehyde dehydrogenase (glutathione) activity" ]

[ "EXACT" ]

[]

[ "GO:0051903", "GO:0051907" ]

[]

null

true

8

GO:0004328

4,328

formamidase activity

molecular_function

Catalysis of the reaction: formamide + H2O = formate + NH4.

[ "RHEA:21948" ]

null

[ "formamide amidohydrolase activity", "formamide hydrolase activity" ]

[ "RELATED", "EXACT" ]

[ "GO:0034566" ]

[]

[ "EC:3.5.1.49", "KEGG_REACTION:R00524", "MetaCyc:FORMAMIDASE-RXN", "RHEA:21948", "UM-BBD_reactionID:r0873" ]

[ "GO:0004040" ]

[]

[ "GO:0004040" ]

[]

[ "skos:exactMatch EC:3.5.1.49", "skos:exactMatch RHEA:21948", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28070\" xsd:anyURI" ]

null

false

true

1