go_id string | go_numeric_id int64 | name string | namespace string | definition string | definition_xrefs list | comment string | synonyms list | synonym_scopes list | alt_ids list | subsets list | xrefs list | is_a_ids list | relationship_edges list | relationship_types list | relationship_target_ids list | parent_ids list | intersection_of list | union_of list | disjoint_from list | replaced_by list | consider list | property_values list | created_by string | creation_date string | is_obsolete bool | in_go_basic bool | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GO:0004329 | 4,329 | formate-tetrahydrofolate ligase activity | molecular_function | Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. | [
"EC:6.3.4.3"
] | null | [
"10-formyl-THF synthetase activity",
"10-formyltetrahydrofolate synthetase activity",
"formate:tetrahydrofolate ligase (ADP-forming)",
"formyltetrahydrofolate synthetase activity",
"tetrahydrofolate formylase activity",
"tetrahydrofolic formylase activity"
] | [
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.3.4.3",
"MetaCyc:FORMATETHFLIG-RXN",
"Reactome:R-HSA-200711 \"MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG\"",
"Reactome:R-HSA-5696839 \"MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF\"",
"Reactome:R-HSA-6801456 \"MTHFD1L transforms 10-formyl-THF to HCOOH and THF\"",
"RHEA:2... | [
"GO:0016879"
] | [] | [] | [] | [
"GO:0016879"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.4.3",
"skos:exactMatch RHEA:20221",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004331 | 4,331 | fructose-2,6-bisphosphate 2-phosphatase activity | molecular_function | Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate. | [
"EC:3.1.3.46"
] | null | [
"beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity",
"D-fructose-2,6-bisphosphate 2-phosphohydrolase activity",
"fructose-2,6-bisphosphatase activity"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [
"GO:0004330"
] | [] | [
"EC:3.1.3.46",
"MetaCyc:3.1.3.46-RXN",
"Reactome:R-HSA-5628905 \"TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate\"",
"Reactome:R-HSA-70262 \"PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate\"",
"RHEA:17289"
] | [
"GO:0050308"
] | [] | [] | [] | [
"GO:0050308"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.3.46",
"skos:exactMatch RHEA:17289",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004332 | 4,332 | fructose-bisphosphate aldolase activity | molecular_function | Catalysis of the reaction: beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate. | [
"EC:4.1.2.13"
] | null | [
"1,6-diphosphofructose aldolase activity",
"aldolase activity",
"D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)",
"D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity",
"diphosphofructose aldolase activity",
"fructoaldolase activity",
"fr... | [
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.1.2.13",
"MetaCyc:F16ALDOLASE-RXN",
"Reactome:R-HSA-71495 \"Aldolase tetramers convert GA3P and DHAP to F1,6PP\"",
"Reactome:R-HSA-71496 \"Aldolase tetramer cleaves F1,6PP\"",
"RHEA:14729"
] | [
"GO:0016832"
] | [] | [] | [] | [
"GO:0016832"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.2.13",
"skos:exactMatch RHEA:14729",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27617\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004333 | 4,333 | fumarate hydratase activity | molecular_function | Catalysis of the reaction: (S)-malate = fumarate + H2O. | [
"EC:4.2.1.2",
"RHEA:12460"
] | null | [
"(S)-malate hydro-lyase (fumarate-forming)",
"(S)-malate hydro-lyase activity",
"fumarase activity",
"L-malate hydro-lyase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.2.1.2",
"KEGG_REACTION:R01082",
"MetaCyc:FUMHYDR-RXN",
"Reactome:R-HSA-70982 \"FH tetramer hydrates fumarate to L-malate\"",
"RHEA:12460"
] | [
"GO:0016836"
] | [] | [] | [] | [
"GO:0016836"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.2.1.2",
"skos:exactMatch RHEA:12460",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004334 | 4,334 | fumarylacetoacetase activity | molecular_function | Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+. | [
"EC:3.7.1.2",
"RHEA:10244"
] | null | [
"4-fumarylacetoacetate fumarylhydrolase activity",
"beta-diketonase activity",
"fumarylacetoacetate hydrolase activity"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.7.1.2",
"KEGG_REACTION:R01364",
"MetaCyc:FUMARYLACETOACETASE-RXN",
"Reactome:R-HSA-71181 \"FAH cleaves 4FAA\"",
"RHEA:10244",
"UM-BBD_reactionID:r0107"
] | [
"GO:0016823"
] | [] | [] | [] | [
"GO:0016823"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.7.1.2",
"skos:exactMatch RHEA:10244",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004335 | 4,335 | galactokinase activity | molecular_function | Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H+. | [
"EC:2.7.1.6",
"RHEA:13553"
] | null | [
"ATP:D-galactose 1-phosphotransferase activity",
"ATP:D-galactose-1-phosphotransferase activity",
"galactokinase (phosphorylating)"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.6",
"KEGG_REACTION:R01092",
"MetaCyc:GALACTOKIN-RXN",
"Reactome:R-HSA-5610026 \"Defective GALK1 does not phosphorylate Gal\"",
"Reactome:R-HSA-70355 \"GALK1 phosphorylates Gal to Gal1P\"",
"RHEA:13553"
] | [
"GO:0016773",
"GO:0019200"
] | [] | [] | [] | [
"GO:0016773",
"GO:0019200"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.6",
"skos:exactMatch RHEA:13553",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004336 | 4,336 | galactosylceramidase activity | molecular_function | Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine. | [
"EC:3.2.1.46"
] | null | [
"beta-galactocerebrosidase activity",
"beta-galactosylceramidase activity",
"ceramide galactosidase activity",
"cerebroside beta-galactosidase activity",
"cerebroside galactosidase activity",
"D-galactosyl-N-acylsphingosine galactohydrolase activity",
"galactocerebrosidase activity",
"galactocerebrosi... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.2.1.46",
"MetaCyc:GALACTOSYLCERAMIDASE-RXN",
"Reactome:R-HSA-1606564 \"GALC hydrolyzes GalCer\"",
"RHEA:14297"
] | [
"GO:0017042"
] | [] | [] | [] | [
"GO:0017042"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.46",
"skos:exactMatch MetaCyc:GALACTOSYLCERAMIDASE-RXN",
"skos:exactMatch RHEA:14297",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25793\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004337 | 4,337 | (2E,6E)-farnesyl diphosphate synthase activity | molecular_function | Catalysis of the reaction: (2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate. | [
"RHEA:19361"
] | Note that this is the second step in the formation of farnesyl diphosphate. The first step is 'dimethylallyltransferase activity ; GO:0004161'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. | [
"farnesyl diphosphate synthase activity",
"farnesyl diphosphate synthetase activity",
"farnesyl pyrophosphate synthetase activity",
"farnesyl-diphosphate synthase activity",
"farnesylpyrophosphate synthetase activity",
"FPP synthetase activity",
"geranyl transferase I",
"geranyl-diphosphate:isopenteny... | [
"EXACT",
"RELATED",
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:2.5.1.10",
"KEGG_REACTION:R02003",
"MetaCyc:FPPSYN-RXN",
"Reactome:R-HSA-191303 \"FDPS dimer transfers IPPP to GPP\"",
"Reactome:R-HSA-8870469 \"RGGT geranylgeranylates RAB proteins\"",
"Reactome:R-HSA-9717830 \"GGPS1 hexamer transfers IPPP to GPP\"",
"RHEA:19361"
] | [
"GO:0120531"
] | [] | [] | [] | [
"GO:0120531"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.5.1.10",
"skos:exactMatch RHEA:19361",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20661\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28819\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontol... | null | null | false | true | 4 |
GO:0004338 | 4,338 | glucan exo-1,3-beta-glucosidase activity | molecular_function | Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose. | [
"EC:3.2.1.58"
] | null | [
"1,3-beta-glucan glucohydrolase activity",
"beta-1,3-glucan exo-hydrolase activity",
"exo (1->3)-beta-glucanase activity",
"exo-1,3-beta-D-glucanase activity",
"exo-1,3-beta-glucanase activity",
"exo-1,3-beta-glucosidase activity",
"exo-beta-(1->3)-D-glucanase activity",
"exo-beta-(1->3)-glucanohydrol... | [
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD"
] | [] | [] | [
"EC:3.2.1.58",
"MetaCyc:3.2.1.58-RXN"
] | [
"GO:0008422"
] | [] | [] | [] | [
"GO:0008422"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.58",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004339 | 4,339 | glucan 1,4-alpha-glucosidase activity | molecular_function | Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose. | [
"EC:3.2.1.3"
] | Note that this term is not a child of 'alpha-glucosidase activity ; GO:0090599', because in the reaction represented by GO:0004339 results in the release of beta-D-glucose, whereas in GO:0090599 alpha-D-glucose is released. | [
"1,4-alpha-D-glucan glucohydrolase activity",
"amyloglucosidase activity",
"exo-1,4-alpha-glucosidase activity",
"gamma-1,4-glucan glucohydrolase activity",
"gamma-amylase activity",
"glucoamylase activity",
"glucose amylase activity",
"lysosomal alpha-glucosidase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"BROAD"
] | [] | [] | [
"EC:3.2.1.3",
"MetaCyc:3.2.1.3-RXN"
] | [
"GO:0090599"
] | [] | [] | [] | [
"GO:0090599"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.3",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28262\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004340 | 4,340 | glucokinase activity | molecular_function | Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate. | [
"EC:2.7.1.2"
] | null | [
"ATP:D-glucose 6-phosphotransferase activity",
"glucokinase (phosphorylating)",
"glucose kinase activity"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.2",
"MetaCyc:GLUCOKIN-RXN",
"Reactome:R-HSA-5621888 \"Defective HK1 does not phosphorylate Glc to form G6P\"",
"Reactome:R-HSA-5621918 \"Defective GCK does not phosphorylate Glc to form G6P\"",
"Reactome:R-HSA-70420 \"HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P\"",
"RHEA:17825",
"RHEA:3649... | [
"GO:0004396"
] | [
"part_of GO:0051156"
] | [
"part_of"
] | [
"GO:0051156"
] | [
"GO:0004396",
"GO:0051156"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.2",
"skos:exactMatch RHEA:17825",
"skos:narrowMatch RHEA:36495",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004341 | 4,341 | gluconolactonase activity | molecular_function | Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate. | [
"EC:3.1.1.17"
] | null | [
"aldonolactonase activity",
"D-glucono-1,5-lactone lactonohydrolase activity",
"glucono-delta-lactonase activity",
"gulonolactonase activity",
"lactonase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD"
] | [] | [] | [
"EC:3.1.1.17",
"MetaCyc:GLUCONOLACT-RXN",
"RHEA:10440"
] | [
"GO:0052689"
] | [] | [] | [] | [
"GO:0052689"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.1.17",
"skos:exactMatch RHEA:10440",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004342 | 4,342 | glucosamine-6-phosphate deaminase activity | molecular_function | Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4. | [
"EC:3.5.99.6",
"RHEA:12172"
] | null | [
"2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)",
"aminodeoxyglucosephosphate isomerase activity",
"GlcN6P deaminase activity",
"glucosamine phosphate deaminase activity",
"glucosamine-6-phosphate isomerase activity",
"glucosaminephosphate isomerase",
"phosphoglucosamine isomer... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.99.6",
"KEGG_REACTION:R00765",
"MetaCyc:GLUCOSAMINE-6-P-DEAMIN-RXN",
"Reactome:R-HSA-6799604 \"GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P\"",
"RHEA:12172"
] | [
"GO:0019239"
] | [] | [] | [] | [
"GO:0019239"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.99.6",
"skos:exactMatch RHEA:12172",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19833\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004343 | 4,343 | glucosamine 6-phosphate N-acetyltransferase activity | molecular_function | Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+. | [
"EC:2.3.1.4",
"RHEA:10292"
] | null | [
"acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity",
"aminodeoxyglucosephosphate acetyltransferase activity",
"D-glucosamine-6-P N-acetyltransferase activity",
"glucosamine 6-phosphate acetylase activity",
"glucosamine-6-phosphate acetylase activity",
"glucosamine-phosphate N-acetyltransfe... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.3.1.4",
"KEGG_REACTION:R02058",
"MetaCyc:GLUCOSAMINEPNACETYLTRANS-RXN",
"Reactome:R-HSA-449734 \"Acetylation of glucosamine 6-phosphate to GlcNAc6P\"",
"RHEA:10292"
] | [
"GO:0008080"
] | [] | [] | [] | [
"GO:0008080"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.4",
"skos:exactMatch RHEA:10292",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004344 | 4,344 | glucose dehydrogenase activity | molecular_function | Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor. | [
"PMID:22027299"
] | null | [
"glucose dehydrogenase (acceptor) activity",
"soluble glucose dehydrogenase"
] | [
"EXACT",
"EXACT"
] | [
"GO:0008708"
] | [] | [
"EC:1.1.99.35",
"RHEA:24540"
] | [
"GO:0016614"
] | [] | [] | [] | [
"GO:0016614"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.99.35",
"skos:exactMatch RHEA:24540",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22585\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004345 | 4,345 | glucose-6-phosphate dehydrogenase activity | molecular_function | Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. | [
"EC:1.1.1.49"
] | null | [
"6-phosphoglucose dehydrogenas",
"6-phosphoglucose dehydrogenase activity",
"D-glucose 6-phosphate dehydrogenase activity",
"D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity",
"Entner-doudoroff enzyme",
"G6PD activity",
"G6PDH",
"GDH",
"glucose 6-phosphate dehydrogenase (NADP) activity",
"glu... | [
"RELATED",
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:1.1.1.49",
"MetaCyc:GLU6PDEHYDROG-RXN",
"Reactome:R-HSA-70377 \"G6PD multimers dehydrogenate G6P\"",
"RHEA:15841"
] | [
"GO:0016616"
] | [] | [] | [] | [
"GO:0016616"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.49",
"skos:exactMatch RHEA:15841",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004347 | 4,347 | glucose-6-phosphate isomerase activity | molecular_function | Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate. | [
"RHEA:11816"
] | null | [
"D-glucose-6-phosphate aldose-ketose-isomerase activity",
"D-glucose-6-phosphate ketol-isomerase activity",
"glucose phosphate isomerase activity",
"hexose monophosphate isomerase activity",
"hexose phosphate isomerase activity",
"hexosephosphate isomerase activity",
"oxoisomerase activity",
"phosphog... | [
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"BROAD",
"BROAD"
] | [] | [] | [
"EC:5.3.1.9",
"MetaCyc:PGLUCISOM-RXN",
"Reactome:R-HSA-70471 \"GPI dimer isomerizes G6P\"",
"Reactome:R-HSA-70475 \"GPI dimer isomerizes Fru(6)P to G6P\"",
"RHEA:11816"
] | [
"GO:0016861"
] | [] | [] | [] | [
"GO:0016861"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.3.1.9",
"skos:exactMatch MetaCyc:PGLUCISOM-RXN",
"skos:exactMatch RHEA:11816",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29187\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004348 | 4,348 | glucosylceramidase activity | molecular_function | Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. | [
"EC:3.2.1.45"
] | null | [
"acid beta-glucosidase activity",
"beta-D-glucocerebrosidase activity",
"beta-glucocerebrosidase activity",
"beta-glucosylceramidase activity",
"ceramide glucosidase activity",
"D-glucosyl-N-acylsphingosine glucohydrolase activity",
"GlcCer-beta-glucosidase activity",
"glucocerebrosidase activity",
... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.2.1.45",
"MetaCyc:GLUCOSYLCERAMIDASE-RXN",
"Reactome:R-HSA-1605591 \"GBA1:SAPC hydrolyzes GlcCer\"",
"Reactome:R-HSA-1861788 \"GBA2 hydrolyzes GlcCer (plasma membrane)\"",
"Reactome:R-HSA-1861789 \"GBA3 hydrolyzes GlcCer (cytosol)\"",
"RHEA:13269",
"RHEA:59284"
] | [
"GO:0017042"
] | [] | [] | [] | [
"GO:0017042"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.45",
"skos:exactMatch MetaCyc:GLUCOSYLCERAMIDASE-RXN",
"skos:exactMatch RHEA:13269",
"skos:narrowMatch RHEA:59284",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25793\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004349 | 4,349 | glutamate 5-kinase activity | molecular_function | Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H+. | [
"EC:2.7.2.11",
"RHEA:14877"
] | null | [
"ATP-L-glutamate 5-phosphotransferase activity",
"ATP:gamma-L-glutamate phosphotransferase activity",
"ATP:L-glutamate 5-phosphotransferase activity",
"gamma-glutamate kinase activity",
"gamma-glutamyl kinase activity",
"glutamate kinase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.2.11",
"KEGG_REACTION:R00239",
"MetaCyc:GLUTKIN-RXN",
"RHEA:14877"
] | [
"GO:0016774",
"GO:0019202"
] | [] | [] | [] | [
"GO:0016774",
"GO:0019202"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.2.11",
"skos:exactMatch RHEA:14877",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004351 | 4,351 | glutamate decarboxylase activity | molecular_function | Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. | [
"EC:4.1.1.15"
] | null | [
"aspartic alpha-decarboxylase",
"cysteic acid decarboxylase activity",
"gamma-glutamate decarboxylase activity",
"L-aspartate-alpha-decarboxylase activity",
"L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)",
"L-glutamate 1-carboxy-lyase activity",
"L-glutamate alpha-decarboxylase activity",
"L-... | [
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.1.1.15",
"MetaCyc:GLUTDECARBOX-RXN",
"Reactome:R-HSA-888572 \"PXLP-K405-GAD1 decarboxylates L-Glu to form GABA\"",
"Reactome:R-HSA-888577 \"Synthesis of GABA by GAD2\"",
"RHEA:17785"
] | [
"GO:0016831"
] | [] | [] | [] | [
"GO:0016831"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.1.15",
"skos:exactMatch RHEA:17785",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004352 | 4,352 | L-glutamate dehydrogenase (NAD+) activity | molecular_function | Catalysis of the reaction: L-glutamate + NAD+ + H2O = 2-oxoglutarate + NH4+ + NADH + H+. | [
"RHEA:15133"
] | null | [
"glutamate dehydrogenase (NAD)",
"glutamate dehydrogenase (NAD+) activity",
"glutamate oxidoreductase activity",
"glutamic acid dehydrogenase",
"glutamic dehydrogenase activity",
"L-glutamate dehydrogenase",
"L-glutamate:NAD+ oxidoreductase (deaminating)",
"NAD-dependent glutamate dehydrogenase activi... | [
"BROAD",
"BROAD",
"RELATED",
"BROAD",
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.4.1.2",
"MetaCyc:GLUTAMATE-DEHYDROGENASE-RXN",
"RHEA:15133"
] | [
"GO:0004353"
] | [] | [] | [] | [
"GO:0004353"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.4.1.2",
"skos:exactMatch RHEA:15133",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28527\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontolo... | null | null | false | true | 8 |
GO:0004353 | 4,353 | L-glutamate dehydrogenase [NAD(P)+] activity | molecular_function | Catalysis of the reaction: L-glutamate + NAD(P)+ + H2O = 2-oxoglutarate + NH4+ + NAD(P)H + H+. | [
"EC:1.4.1.3"
] | null | [
"glutamate dehydrogenase (NAD+) activity",
"glutamic dehydrogenase activity",
"L-glutamate:NAD(P)+ oxidoreductase (deaminating)"
] | [
"RELATED",
"BROAD",
"EXACT"
] | [] | [] | [
"EC:1.4.1.3",
"MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN",
"Reactome:R-HSA-70589 \"alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)\"",
"Reactome:R-HSA-70600 \"glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)\""
] | [
"GO:0050018"
] | [] | [] | [] | [
"GO:0050018"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.4.1.3",
"skos:exactMatch MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28526\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28527\" xsd:anyURI",
"term_tracker_item \"https://gi... | null | null | false | true | 5 |
GO:0004354 | 4,354 | L-glutamate dehydrogenase (NADP+) activity | molecular_function | Catalysis of the reaction: L-glutamate + NADP+ + H2O = 2-oxoglutarate + NH4+ + NADPH + H+. | [
"RHEA:11612"
] | null | [
"dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))",
"glutamic acid dehydrogenase",
"glutamic dehydrogenase activity",
"L-glutamate dehydrogenase",
"L-glutamate:NADP+ oxidoreductase (deaminating)",
"L-glutamic acid dehydrogenase activity",
"NAD(P)-glutamate dehydrogenase activity"... | [
"RELATED",
"BROAD",
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.4.1.4",
"MetaCyc:GLUTDEHYD-RXN",
"RHEA:11612"
] | [
"GO:0004353"
] | [] | [] | [] | [
"GO:0004353"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.4.1.4",
"skos:exactMatch MetaCyc:GLUTDEHYD-RXN",
"skos:exactMatch RHEA:11612",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28526\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30646\" xsd:anyURI",
"term_tracker_item ... | null | null | false | true | 2 |
GO:0004355 | 4,355 | glutamate synthase (NADPH) activity | molecular_function | Catalysis of the reaction: 2 L-glutamate + NADP+ = 2-oxoglutarate + L-glutamine + H+ + NADPH. This is a two-step reaction: (a) L-glutamate + NH4+ = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH4+ + 2-oxoglutarate + NADPH + H+. | [
"RHEA:15501"
] | null | [
"glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity",
"glutamate synthetase (NADP) activity",
"glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity",
"glutamine-ketoglutaric aminotransferase activity",
"GOGAT activity",
"L-glutamate synthase activi... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.4.1.13",
"KEGG_REACTION:R00114",
"MetaCyc:GLUTAMATESYN-RXN",
"RHEA:15501"
] | [
"GO:0015930"
] | [] | [] | [] | [
"GO:0015930"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.4.1.13",
"skos:exactMatch MetaCyc:GLUTAMATESYN-RXN",
"skos:exactMatch RHEA:15501",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28526\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31587\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004356 | 4,356 | glutamine synthetase activity | molecular_function | Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate. | [
"RHEA:16169"
] | null | [
"glutamate-ammonia ligase activity",
"L-glutamine synthetase activity"
] | [
"EXACT",
"RELATED"
] | [] | [] | [
"EC:6.3.1.2",
"KEGG_REACTION:R00253",
"MetaCyc:GLUTAMINESYN-RXN",
"Reactome:R-HSA-70606 \"glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]\"",
"RHEA:16169"
] | [
"GO:0016211"
] | [] | [] | [] | [
"GO:0016211"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.1.2",
"skos:exactMatch RHEA:16169",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25543\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004357 | 4,357 | glutamate-cysteine ligase activity | molecular_function | Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate. | [
"EC:6.3.2.2",
"RHEA:13285"
] | null | [
"gamma-glutamyl-L-cysteine synthetase activity",
"gamma-glutamylcysteine synthetase activity",
"gamma-glutamylcysteinyl synthetase activity",
"L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.3.2.2",
"KEGG_REACTION:R00894",
"MetaCyc:GLUTCYSLIG-RXN",
"Reactome:R-HSA-174367 \"GCL ligates L-Glu to L-Cys\"",
"Reactome:R-HSA-5602892 \"Defective GCLC does not ligate L-Glu to L-Cys\"",
"RHEA:13285"
] | [
"GO:0016881"
] | [] | [] | [] | [
"GO:0016881"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.2.2",
"skos:exactMatch RHEA:13285",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004358 | 4,358 | L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor | molecular_function | Catalysis of the reaction: N2-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine. | [
"RHEA:15349"
] | null | [
"2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity",
"acetyl-L-glutamate:acetyl-L-ornithine transacetylase activity",
"acetylglutamate synthetase activity",
"acetylglutamate-acetylornithine transacetylase activity",
"acetylglutamic synthetase activity",
"acetylglutamic-acetylornithine transa... | [
"EXACT",
"EXACT",
"BROAD",
"EXACT",
"BROAD",
"EXACT",
"BROAD",
"EXACT",
"EXACT",
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"EXACT",
"BROAD",
"BROAD"
] | [] | [] | [
"EC:2.3.1.35",
"KEGG_REACTION:R02282",
"MetaCyc:GLUTAMATE-N-ACETYLTRANSFERASE-RXN",
"RHEA:15349"
] | [
"GO:0140085"
] | [] | [] | [] | [
"GO:0140085"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.35",
"skos:exactMatch KEGG_REACTION:R02282",
"skos:exactMatch RHEA:15349",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30002\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004360 | 4,360 | L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity | molecular_function | Catalysis of the reaction: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. | [
"RHEA:13237"
] | null | [
"D-fructose-6-phosphate amidotransferase activity",
"GlcN6P synthase activity",
"glucosamine 6-phosphate synthase activity",
"glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity",
"glucosamine-6-phosphate isomerase (glutamine-forming) activity",
"glucosamine-6-phosphate synthase acti... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"BROAD",
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.6.1.16",
"KEGG_REACTION:R00768",
"MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-RXN",
"Reactome:R-HSA-4085027 \"Defective GFPT1 does not transfer an amino group from L-Gln to F6P to form GlcN6P\"",
"Reactome:R-HSA-449715 \"GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P\"",
"RHEA:13237"
] | [
"GO:0140385"
] | [] | [] | [] | [
"GO:0140385"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.6.1.16",
"skos:exactMatch RHEA:13237",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31140\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004361 | 4,361 | glutaryl-CoA dehydrogenase activity | molecular_function | Catalysis of the reaction: glutaryl-CoA + 2 H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]. | [
"RHEA:13389"
] | null | [
"glutaryl coenzyme A dehydrogenase activity"
] | [
"RELATED"
] | [] | [] | [
"EC:1.3.8.6",
"MetaCyc:GLUTARYL-COA-DEHYDROGENASE-RXN",
"Reactome:R-HSA-71046 \"glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2\"",
"RHEA:13389",
"UM-BBD_reactionID:r0198"
] | [
"GO:0003995"
] | [] | [] | [] | [
"GO:0003995"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.3.8.6",
"skos:exactMatch RHEA:13389",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23497\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26435\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontolo... | null | null | false | true | 9 |
GO:0004362 | 4,362 | glutathione-disulfide reductase (NADPH) activity | molecular_function | Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+. | [
"PMID:36771108",
"RHEA:11740"
] | null | [
"glutathione reductase activity",
"glutathione S-reductase activity",
"glutathione-disulfide reductase (NADP) activity",
"glutathione-disulfide reductase activity",
"glutathione-disulphide reductase activity",
"glutathione:NADP+ oxidoreductase activity",
"GSH reductase activity",
"GSSG reductase activ... | [
"EXACT",
"RELATED",
"EXACT",
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.8.1.7",
"MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN",
"Reactome:R-HSA-3323079 \"GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+\"",
"Reactome:R-HSA-71682 \"glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+\"",
"RHEA:11740"
] | [
"GO:0015038",
"GO:0016209",
"GO:0016668"
] | [] | [] | [] | [
"GO:0015038",
"GO:0016209",
"GO:0016668"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.8.1.7",
"skos:exactMatch RHEA:11740",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25461\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25498\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontolo... | null | null | false | true | 1 |
GO:0004363 | 4,363 | glutathione synthase activity | molecular_function | Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate. | [
"EC:6.3.2.3",
"RHEA:13557"
] | null | [
"gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)",
"glutathione synthetase activity",
"GSH synthetase activity"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.3.2.3",
"KEGG_REACTION:R00497",
"MetaCyc:GLUTATHIONE-SYN-RXN",
"Reactome:R-HSA-174394 \"GSS:Mg2+ dimer synthesizes GSH\"",
"Reactome:R-HSA-5602901 \"Defective GSS does not synthesize GSH\"",
"RHEA:13557"
] | [
"GO:0016881",
"GO:1904091"
] | [
"part_of GO:0006750"
] | [
"part_of"
] | [
"GO:0006750"
] | [
"GO:0006750",
"GO:0016881",
"GO:1904091"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.2.3",
"skos:exactMatch RHEA:13557",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004364 | 4,364 | glutathione transferase activity | molecular_function | Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+. | [
"RHEA:16437"
] | null | [
"glutathione conjugation reaction",
"glutathione S-alkyl transferase activity",
"glutathione S-alkyltransferase activity",
"glutathione S-aralkyltransferase activity",
"glutathione S-aryltransferase activity",
"glutathione S-transferase activity",
"RX:glutathione R-transferase activity",
"S-(hydroxyal... | [
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.5.1.18",
"MetaCyc:GSHTRAN-RXN",
"Reactome:R-HSA-176054 \"GST dimers conjugate GSH with cytosolic substrates\"",
"Reactome:R-HSA-176059 \"GST trimers transfer GS from GSH to luminal substrates\"",
"Reactome:R-HSA-3301943 \"GSTK1 dimer transfers GS from GSH to CDNB\"",
"Reactome:R-HSA-5423653 \"MGST t... | [
"GO:0016765"
] | [] | [] | [] | [
"GO:0016765"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.5.1.18",
"skos:exactMatch RHEA:16437",
"skos:narrowMatch RHEA:51220",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31085\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004365 | 4,365 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | molecular_function | Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. | [
"EC:1.2.1.12"
] | null | [
"3-phosphoglyceraldehyde dehydrogenase activity",
"D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)",
"dehydrogenase, glyceraldehyde phosphate",
"GAPDH activity",
"glyceraldehyde phosphate dehydrogenase (NAD)",
"glyceraldehyde-3-P-dehydrogenase activity",
"NAD-dependent glyceraldehyde ... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD"
] | [] | [] | [
"EC:1.2.1.12",
"MetaCyc:GAPOXNPHOSPHN-RXN",
"Reactome:R-HSA-70449 \"GADPH tetramer dehydrogenates GA3P\"",
"Reactome:R-HSA-70482 \"GAPDH tetramers reduce 1,3BPG to GA3P\"",
"RHEA:10300"
] | [
"GO:0043891"
] | [] | [] | [] | [
"GO:0043891"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.2.1.12",
"skos:exactMatch RHEA:10300",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004366 | 4,366 | glycerol-3-phosphate O-acyltransferase activity | molecular_function | Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA. | [
"RHEA:15325"
] | null | [
"3-glycerophosphate acyltransferase activity",
"ACP:sn-glycerol-3-phosphate acyltransferase activity",
"acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity",
"alpha-glycerophosphate acyltransferase activity",
"glycerol 3-phosphate acyltransferase activity",
"glycerol phosphate acyltransferase ac... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.3.1.15",
"MetaCyc:RXN-1381",
"Reactome:R-HSA-1482695 \"G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)\"",
"Reactome:R-HSA-549112 \"G3P is acylated to 1-acyl LPA by AGPAT6\"",
"Reactome:R-HSA-75886 \"glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associa... | [
"GO:0008374"
] | [] | [] | [] | [
"GO:0008374"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.15",
"skos:exactMatch RHEA:15325",
"skos:narrowMatch RHEA:35723",
"skos:narrowMatch RHEA:35727",
"skos:narrowMatch RHEA:35731",
"skos:narrowMatch RHEA:37195",
"skos:narrowMatch RHEA:37199",
"skos:narrowMatch RHEA:37203",
"skos:narrowMatch RHEA:37463",
"term_tracker_item \... | null | null | false | true | 9 |
GO:0004368 | 4,368 | glycerol-3-phosphate dehydrogenase (quinone) activity | molecular_function | Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. | [
"EC:1.1.5.3"
] | null | [
"FAD-dependent glycerol-3-phosphate dehydrogenase",
"flavin-linked glycerol-3-phosphate dehydrogenase",
"glycerol-3-phosphate CoQ reductase",
"glycerophosphate dehydrogenase activity",
"L-glycerophosphate dehydrogenase activity",
"sn-glycerol-3-phosphate dehydrogenase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.1.5.3",
"MetaCyc:RXN-15745",
"Reactome:R-HSA-188467 \"Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)\"",
"RHEA:18977",
"RHEA:28755",
"RHEA:29219"
] | [
"GO:0016901"
] | [] | [] | [] | [
"GO:0016901"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.5.3",
"skos:exactMatch RHEA:18977",
"skos:narrowMatch RHEA:28755",
"skos:narrowMatch RHEA:29219",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25984\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"... | null | null | false | true | 5 |
GO:0004369 | 4,369 | glycerol-3-phosphate oxidase activity | molecular_function | Catalysis of the reaction: sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2. | [
"EC:1.1.3.21",
"RHEA:18369"
] | null | [
"alpha-glycerophosphate oxidase activity",
"glycerol phosphate oxidase activity",
"glycerol-1-phosphate oxidase activity",
"L-alpha-glycerol-3-phosphate oxidase activity",
"L-alpha-glycerophosphate oxidase activity",
"sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.1.3.21",
"KEGG_REACTION:R00846",
"MetaCyc:GLYCEROL-3-PHOSPHATE-OXIDASE-RXN",
"RHEA:18369"
] | [
"GO:0016899"
] | [] | [] | [] | [
"GO:0016899"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.3.21",
"skos:exactMatch RHEA:18369",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004370 | 4,370 | glycerol kinase activity | molecular_function | Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H+. | [
"EC:2.7.1.30",
"RHEA:21644"
] | null | [
"ATP:glycerol 3-phosphotransferase activity",
"ATP:glycerol-3-phosphotransferase activity",
"GK",
"glyceric kinase activity",
"glycerokinase activity",
"glycerol kinase (phosphorylating)"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.30",
"KEGG_REACTION:R00847",
"MetaCyc:GLYCEROL-KIN-RXN",
"Reactome:R-HSA-75887 \"Conversion of Glycerol to Glycerol-3-phosphate\"",
"RHEA:21644"
] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.30",
"skos:exactMatch RHEA:21644",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004371 | 4,371 | glycerone kinase activity | molecular_function | Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+. | [
"EC:2.7.1.29",
"RHEA:15773"
] | null | [
"acetol kinase (phosphorylating)",
"acetol kinase activity",
"ATP:glycerone phosphotransferase activity",
"dihydroxyacetone kinase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.29",
"KEGG_REACTION:R01011",
"MetaCyc:GLYCERONE-KINASE-RXN",
"RHEA:15773"
] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.29",
"skos:exactMatch RHEA:15773",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004372 | 4,372 | glycine hydroxymethyltransferase activity | molecular_function | Catalysis of the reaction: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine. | [
"RHEA:15481"
] | null | [
"5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity",
"allothreonine aldolase activity",
"L-serine hydroxymethyltransferase activity",
"serine aldolase activity",
"serine hydroxymethylase activity",
"serine hydroxymethyltransferase activity",
"serine transhydroxymethylase activity"... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"MetaCyc:GLYOHMETRANS-RXN",
"Reactome:R-HSA-5694137 \"PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser\"",
"RHEA:15481"
] | [
"GO:0016742"
] | [] | [] | [] | [
"GO:0016742"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:2.1.2.1",
"skos:exactMatch MetaCyc:GLYOHMETRANS-RXN",
"skos:exactMatch RHEA:15481",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30653\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004373 | 4,373 | alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity | molecular_function | Catalysis of the reaction: [(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + H+ + UDP. | [
"RHEA:18549"
] | null | [
"glycogen (starch) synthetase activity",
"glyucogen (starch) synthase activity",
"UDP-glucose-glycogen glucosyltransferase activity",
"UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity",
"UDP-glycogen synthase activity",
"UDPG-glycogen synthetase activity",
"UDPG-glycogen transglucosylase acti... | [
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.1.11",
"MetaCyc:RXN-7668",
"Reactome:R-HSA-3322001 \"GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1\"",
"Reactome:R-HSA-3322009 \"GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2\"",
"Reactome:R-HSA-3322041 \"Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1\"",
"Rea... | [
"GO:0033840",
"GO:0035251"
] | [] | [] | [] | [
"GO:0033840",
"GO:0035251"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.11",
"skos:exactMatch RHEA:18549",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28271\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004374 | 4,374 | obsolete glycine cleavage system | molecular_function | OBSOLETE. Catalysis of the reactions: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and gl... | [
"GOC:curators"
] | This term was made obsolete because it represents a process rather than a function. | [
"glycine cleavage system",
"glycine synthase"
] | [
"EXACT",
"BROAD"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0019464"
] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28243\" xsd:anyURI"
] | null | null | true | true | 9 |
GO:0004376 | 4,376 | GPI mannosyltransferase activity | molecular_function | Catalysis of the transfer of an alpha-D-mannosyl residue from dolichol-P-mannose to GlcN-acyl-PI bearing 0-3 mannoses during formation of the GPI precursor. | [
"GOC:curators"
] | null | [
"glycolipid mannosyl transferase activity",
"glycolipid mannosyltransferase activity"
] | [
"EXACT",
"BROAD"
] | [
"GO:0004580"
] | [] | [
"Reactome:R-HSA-162821 \"mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate\"",
"Reactome:R-HSA-162873 \"(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + do... | [
"GO:0000030"
] | [] | [] | [] | [
"GO:0000030"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30326\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004377 | 4,377 | GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity | molecular_function | Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNA... | [
"RHEA:29523"
] | null | [
"GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity",
"GDP-mannose-oligosaccharide-lipid mannosyltransferase activity",
"GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity",
"glycolipid 2-a... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.1.131",
"MetaCyc:RXN-5464",
"RHEA:29523"
] | [
"GO:0000026",
"GO:0120562"
] | [] | [] | [] | [
"GO:0000026",
"GO:0120562"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.131",
"skos:exactMatch RHEA:29523",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30326\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004378 | 4,378 | GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity | molecular_function | Catalysis of the reaction: a beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H+. | [
"RHEA:29515"
] | null | [
"GDP-D-mannose:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 3-alpha-mannosyltransferase activity",
"GDP-mannose-oligosaccharide-lipid mannosyltransferase II",
"GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity",
"glycolipid 3-alpha-mannosyltransferase activity",
"guanosine... | [
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.1.132",
"MetaCyc:RXN-5462",
"RHEA:29515"
] | [
"GO:0000033",
"GO:0120562"
] | [] | [] | [] | [
"GO:0000033",
"GO:0120562"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.132",
"skos:exactMatch RHEA:29515",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28212\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-onto... | null | null | false | true | 4 |
GO:0004380 | 4,380 | glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity | molecular_function | Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose. | [
"EC:2.4.1.40"
] | null | [
"A transferase activity",
"A-transferase activity",
"alpha-3-N-acetylgalactosaminyltransferase activity",
"blood-group substance A-dependent acetylgalactosaminyltransferase activity",
"blood-group substance alpha-acetyltransferase activity",
"fucosylgalactose acetylgalactosaminyltransferase activity",
"... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.1.40",
"MetaCyc:2.4.1.40-RXN",
"Reactome:R-HSA-9033959 \"ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC\"",
"Reactome:R-HSA-9034042 \"sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec\"",
"RHEA:19021",
"RHEA:84499",
"RHEA:84507",
"RHEA:84511",
"RHEA:8453... | [
"GO:0008376",
"GO:0140103"
] | [] | [] | [] | [
"GO:0008376",
"GO:0140103"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.40",
"skos:exactMatch RHEA:19021",
"skos:narrowMatch RHEA:84499",
"skos:narrowMatch RHEA:84507",
"skos:narrowMatch RHEA:84511",
"skos:narrowMatch RHEA:84535",
"skos:narrowMatch RHEA:84539",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:an... | null | null | false | true | 9 |
GO:0004381 | 4,381 | fucosylgalactoside 3-alpha-galactosyltransferase activity | molecular_function | Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose. | [
"EC:2.4.1.37"
] | null | [
"[blood group substance] alpha-galactosyltransferase activity",
"B transferase activity",
"blood-group substance B-dependent galactosyltransferase activity",
"blood-group substance beta-dependent galactosyltransferase activity",
"fucosylglycoprotein 3-alpha-galactosyltransferase activity",
"glycoprotein-f... | [
"NARROW",
"RELATED",
"NARROW",
"NARROW",
"RELATED",
"EXACT",
"NARROW",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.1.37",
"MetaCyc:2.4.1.37-RXN",
"Reactome:R-HSA-9033961 \"ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC\"",
"Reactome:R-HSA-9034053 \"sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen\"",
"RHEA:14349",
"RHEA:84519",
"RHEA:84523",
"RHEA:84527",
"RHEA:84739",
"RHE... | [
"GO:0035250"
] | [] | [] | [] | [
"GO:0035250"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.37",
"skos:exactMatch RHEA:14349",
"skos:narrowMatch RHEA:84519",
"skos:narrowMatch RHEA:84523",
"skos:narrowMatch RHEA:84527",
"skos:narrowMatch RHEA:84739",
"skos:narrowMatch RHEA:84743",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:an... | null | null | false | true | 6 |
GO:0004382 | 4,382 | GDP phosphatase activity | molecular_function | Catalysis of the reaction: GDP + H2O = GMP + phosphate. | [
"PMID:2989286",
"RHEA:22156"
] | null | [
"GDP diphosphatase activity",
"GDP phosphohydrolase activity",
"GDPase activity",
"guanosine 5'-diphosphatase activity",
"guanosine diphosphatase activity",
"guanosine-diphosphatase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"EXACT"
] | [] | [] | [
"EC:3.6.1.42",
"MetaCyc:GUANOSINE-DIPHOSPHATASE-RXN",
"Reactome:R-HSA-9947887 \"GBP1 hydrolyzes GDP\"",
"RHEA:22156"
] | [
"GO:0017110"
] | [] | [] | [] | [
"GO:0017110"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.6.1.42",
"skos:exactMatch RHEA:22156",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004383 | 4,383 | guanylate cyclase activity | molecular_function | Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. | [
"EC:4.6.1.2"
] | null | [
"GTP diphosphate-lyase (cyclizing) activity",
"GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity",
"guanyl cyclase activity",
"guanylyl cyclase activity",
"receptor guanylate cyclase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"NARROW"
] | [] | [] | [
"EC:4.6.1.2",
"MetaCyc:GUANYLCYC-RXN",
"Reactome:R-HSA-392152 \"Soluble guanylate cyclase converts GTP to cGMP\"",
"Reactome:R-HSA-74885 \"GUCYs converts GTP to cGMP\"",
"RHEA:13665"
] | [
"GO:0009975",
"GO:0016849"
] | [
"part_of GO:0006182"
] | [
"part_of"
] | [
"GO:0006182"
] | [
"GO:0006182",
"GO:0009975",
"GO:0016849"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.6.1.2",
"skos:exactMatch RHEA:13665",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004384 | 4,384 | obsolete membrane-associated guanylate kinase | molecular_function | OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane. | [
"EC:2.7.4.8"
] | This term was made obsolete because it represents a gene product and not a function. | [
"MAGUK",
"membrane-associated guanylate kinase"
] | [
"EXACT",
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004385",
"GO:0005102",
"GO:0007155",
"GO:0050839"
] | [] | null | null | true | true | 4 |
GO:0004385 | 4,385 | GMP kinase activity | molecular_function | Catalysis of the reaction: ATP + GMP = ADP + GDP. | [
"RHEA:20780"
] | null | [
"5'-GMP kinase activity",
"ATP:(d)GMP phosphotransferase activity",
"ATP:GMP phosphotransferase activity",
"deoxyguanylate kinase activity",
"guanosine monophosphate kinase activity",
"guanylate kinase activity",
"membrane-associated guanylate kinase"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW"
] | [] | [] | [
"EC:2.7.4.8",
"MetaCyc:GUANYL-KIN-RXN",
"Reactome:R-HSA-110133 \"(d)GDP + ADP <=> (d)GMP + ATP (GUK1)\"",
"Reactome:R-HSA-73788 \"(d)GMP + ATP <=> (d)GDP + ADP (GUK1)\"",
"Reactome:R-HSA-9748949 \"GUK1 phosphorylates 6TGMP to 6TGDP\"",
"Reactome:R-HSA-9748963 \"GUK1 phosphorylates 6TdGMP to 6TdGDP\"",
"... | [
"GO:0050145"
] | [
"part_of GO:0046037",
"part_of GO:0046710"
] | [
"part_of",
"part_of"
] | [
"GO:0046037",
"GO:0046710"
] | [
"GO:0046037",
"GO:0046710",
"GO:0050145"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.4.8",
"skos:exactMatch MetaCyc:GUANYL-KIN-RXN",
"skos:exactMatch RHEA:20780",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27917\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29533\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004386 | 4,386 | helicase activity | molecular_function | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. | [
"GOC:jl"
] | Note that most helicases catalyze processive duplex unwinding. | [
"ATP-dependent helicase activity"
] | [
"EXACT"
] | [
"GO:0008026"
] | [
"goslim_candida",
"goslim_chembl",
"goslim_pir",
"goslim_yeast"
] | [
"Reactome:R-HSA-169461 \"MCM8 mediated fork unwinding\"",
"Reactome:R-HSA-169468 \"MCM2-7 mediated fork unwinding\"",
"Reactome:R-HSA-5686410 \"BLM mediates dissolution of double Holliday junction\"",
"Reactome:R-HSA-5690996 \"ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA\"",
"R... | [
"GO:0120545",
"GO:0140640",
"GO:0140657"
] | [] | [] | [] | [
"GO:0120545",
"GO:0140640",
"GO:0140657"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21393\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29690\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004394 | 4,394 | heparan sulfate 2-sulfotransferase activity | molecular_function | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate. | [
"PMID:9153262"
] | null | [
"heparan sulfate 2-O-sulfotransferase activity",
"heparan-sulfate 2-O-sulphotransferase activity",
"heparin 2-sulfotransferase activity",
"heparin-sulphate 2-sulphotransferase activity"
] | [
"EXACT",
"EXACT",
"RELATED",
"RELATED"
] | [] | [] | [
"MetaCyc:RXN-11558",
"Reactome:R-HSA-2076508 \"HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate\""
] | [
"GO:0034483"
] | [] | [] | [] | [
"GO:0034483"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24749\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28380\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004395 | 4,395 | obsolete hexaprenyldihydroxybenzoate methyltransferase activity | molecular_function | OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate. | [
"GOC:curators"
] | This term was obsoleted because it represents a specific substrate of 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity ; GO:0010420 | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0010420"
] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26632\" xsd:anyURI"
] | null | null | true | true | 3 |
GO:0004396 | 4,396 | hexokinase activity | molecular_function | Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. | [
"EC:2.7.1.1"
] | null | [
"ATP-dependent hexokinase activity",
"ATP:D-hexose 6-phosphotransferase activity",
"glucose ATP phosphotransferase activity",
"hexokinase (phosphorylating)",
"hexokinase D",
"hexokinase type I activity",
"hexokinase type II activity",
"hexokinase type III activity",
"hexokinase type IV",
"hexokina... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"NARROW",
"RELATED",
"NARROW",
"RELATED"
] | [] | [] | [
"EC:2.7.1.1",
"MetaCyc:HEXOKINASE-RXN",
"RHEA:22740"
] | [
"GO:0016773",
"GO:0019200"
] | [] | [] | [] | [
"GO:0016773",
"GO:0019200"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.1",
"skos:exactMatch RHEA:22740",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004398 | 4,398 | histidine decarboxylase activity | molecular_function | Catalysis of the reaction: L-histidine = histamine + CO2. | [
"EC:4.1.1.22"
] | null | [
"L-histidine carboxy-lyase (histamine-forming)",
"L-histidine carboxy-lyase activity",
"L-histidine decarboxylase activity"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.1.1.22",
"MetaCyc:HISTIDINE-DECARBOXYLASE-RXN",
"Reactome:R-HSA-977301 \"Histidine is decarboxylated to histamine\"",
"RHEA:20840"
] | [
"GO:0016831"
] | [] | [] | [] | [
"GO:0016831"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.1.22",
"skos:exactMatch RHEA:20840",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004400 | 4,400 | L-histidinol-phosphate:2-oxoglutarate transaminase activity | molecular_function | Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. | [
"RHEA:23744"
] | null | [
"glutamic-imidazoleacetol phosphate transaminase activity",
"histidine:imidazoleacetol phosphate transaminase activity",
"histidinol phosphate aminotransferase activity",
"histidinol-phosphate aminotransferase activity",
"histidinol-phosphate transaminase activity",
"IAP transaminase activity",
"imidazo... | [
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.6.1.9",
"MetaCyc:HISTAMINOTRANS-RXN",
"RHEA:23744"
] | [
"GO:0140385"
] | [] | [] | [] | [
"GO:0140385"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.6.1.9",
"skos:exactMatch RHEA:23744",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31140\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004402 | 4,402 | histone acetyltransferase activity | molecular_function | Catalysis of the reaction: L-lysyl-[histone] + acetyl-CoA = N6-acetyl-L-lysyl-[histone] + CoA + H+. | [
"PMID:19056256",
"RHEA:21992"
] | null | [
"acetyl-CoA:histone acetyltransferase activity",
"H2A/H2B histone acetyltransferase activity",
"H3/H4 histone acetyltransferase activity",
"H4/H2 histone acetyltransferase activity",
"H4/H2A acetyltransferase activity",
"histone acetokinase activity",
"histone acetylase activity",
"histone lysine acet... | [
"RELATED",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"RELATED",
"EXACT",
"EXACT",
"RELATED",
"RELATED"
] | [
"GO:0004403",
"GO:0004404",
"GO:0004405",
"GO:0004406",
"GO:0043166",
"GO:0046971"
] | [] | [
"MetaCyc:HISTONE-ACETYLTRANSFERASE-RXN",
"Reactome:R-HSA-3301237 \"KAT2 complexes acetylate histone H3\"",
"Reactome:R-HSA-3301345 \"Elongator complex acetylates replicative histone H3, H4\"",
"Reactome:R-HSA-3318413 \"KAT7-containing ING4/5 complexes acetylate Me3K-histone H3\"",
"Reactome:R-HSA-3318415 \"... | [
"GO:0061733",
"GO:0140993"
] | [] | [] | [] | [
"GO:0061733",
"GO:0140993"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch RHEA:21992",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28368\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30180\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004407 | 4,407 | histone deacetylase activity | molecular_function | Removal of an acetyl group from a lysine residue in a histone. | [
"PMID:24691964",
"PMID:9893272"
] | Histone deacytylase (HDAC) enzymes are divided into four classes: the Class I Rpd3-like proteins (in human: HDAC1, HDAC2, HDAC3, and HDAC8); the Class II Hda1-like proteins (in human: HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10); the Class III Sir2-like proteins (in human: SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, an... | [
"histone deacetylase activity (NAD-independent)"
] | [
"EXACT"
] | [] | [] | [
"Reactome:R-HSA-2545203 \"Deacetylation of cleaved cohesin\"",
"Reactome:R-HSA-2545253 \"Deacetylation of cohesin\"",
"Reactome:R-HSA-3769447 \"HDAC1:2-containing complex deacetylate histones\"",
"Reactome:R-HSA-3777129 \"HDAC3 containing complexes deacetylate histone\"",
"Reactome:R-HSA-3782637 \"HDAC8 dea... | [
"GO:0033558",
"GO:0140993"
] | [] | [] | [] | [
"GO:0033558",
"GO:0140993"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:2.3.1.-",
"skos:broadMatch EC:3.5.1.-",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22295\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004408 | 4,408 | holocytochrome-c synthase activity | molecular_function | Catalysis of the reaction: holocytochrome c = apocytochrome c + heme. | [
"EC:4.4.1.17"
] | null | [
"cytochrome c heme-lyase activity",
"cytochrome c synthase activity",
"holocytochrome c synthetase activity",
"holocytochrome-c apocytochrome-c-lyase (heme-forming)",
"holocytochrome-c apocytochrome-c-lyase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.4.1.17",
"MetaCyc:HOLOCYTOCHROME-C-SYNTHASE-RXN",
"Reactome:R-HSA-9866217 \"HCCS inserts heme into cytochrome c\"",
"RHEA:22648"
] | [
"GO:0016846",
"GO:0140096"
] | [] | [] | [] | [
"GO:0016846",
"GO:0140096"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.4.1.17",
"skos:exactMatch RHEA:22648",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004409 | 4,409 | homoaconitate hydratase activity | molecular_function | Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H2O. | [
"EC:4.2.1.36",
"RHEA:15485"
] | null | [
"(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]",
"2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity",
"cis-homoaconitase activity",
"HACN activity",
"homoaconitase activity",
"Lys4",
"LysF"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.2.1.36",
"KEGG_REACTION:R04371",
"MetaCyc:HOMOACONITATE-HYDRATASE-RXN",
"RHEA:15485"
] | [
"GO:0016836"
] | [] | [] | [] | [
"GO:0016836"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.2.1.36",
"skos:exactMatch RHEA:15485",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004410 | 4,410 | homocitrate synthase activity | molecular_function | Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H2O = CoA + H+ + homocitrate. | [
"RHEA:12929"
] | null | [
"2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity",
"2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)",
"acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)",
"acetyl-coenzyme A:2-ketoglutarate C-acetyl tr... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.3.3.14",
"KEGG_REACTION:R00271",
"MetaCyc:HOMOCITRATE-SYNTHASE-RXN",
"RHEA:12929"
] | [
"GO:0046912"
] | [] | [] | [] | [
"GO:0046912"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.3.14",
"skos:exactMatch RHEA:12929",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004412 | 4,412 | homoserine dehydrogenase activity | molecular_function | Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+. | [
"EC:1.1.1.3"
] | null | [] | [] | [] | [] | [
"EC:1.1.1.3",
"MetaCyc:HOMOSERDEHYDROG-RXN",
"RHEA:15761"
] | [
"GO:0016616"
] | [] | [] | [] | [
"GO:0016616"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.3",
"skos:exactMatch RHEA:15761",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004413 | 4,413 | homoserine kinase activity | molecular_function | Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+. | [
"EC:2.7.1.39",
"RHEA:13985"
] | null | [
"ATP:L-homoserine O-phosphotransferase activity",
"homoserine kinase (phosphorylating)",
"HSK"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.39",
"KEGG_REACTION:R01771",
"MetaCyc:HOMOSERKIN-RXN",
"RHEA:13985"
] | [
"GO:0016773",
"GO:0019202"
] | [] | [] | [] | [
"GO:0016773",
"GO:0019202"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.39",
"skos:exactMatch RHEA:13985",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004414 | 4,414 | homoserine O-acetyltransferase activity | molecular_function | Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA. | [
"EC:2.3.1.31",
"RHEA:13701"
] | null | [
"acetyl-CoA:L-homoserine O-acetyltransferase activity",
"homoserine acetyltransferase activity",
"homoserine O-trans-acetylase activity",
"homoserine transacetylase activity",
"homoserine-O-transacetylase activity",
"L-homoserine O-acetyltransferase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.3.1.31",
"KEGG_REACTION:R01776",
"MetaCyc:HOMOSERINE-O-ACETYLTRANSFERASE-RXN",
"RHEA:13701"
] | [
"GO:0016413"
] | [] | [] | [] | [
"GO:0016413"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.31",
"skos:exactMatch RHEA:13701",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004416 | 4,416 | hydroxyacylglutathione hydrolase activity | molecular_function | Catalysis of the reaction: an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H+. | [
"RHEA:21864"
] | null | [
"acetoacetylglutathione hydrolase activity",
"glyoxalase II activity",
"S-(2-hydroxyacyl)glutathione hydrolase activity",
"S-2-hydroxylacylglutathione hydrolase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.1.2.6",
"MetaCyc:RXN-7919",
"Reactome:R-HSA-6783221 \"HAGH hydrolyses (R)-S-LGSH to GSH and LACT\"",
"RHEA:21864",
"RHEA:25245"
] | [
"GO:0016790"
] | [] | [] | [] | [
"GO:0016790"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.2.6",
"skos:exactMatch RHEA:21864",
"skos:narrowMatch RHEA:25245",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30176\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004417 | 4,417 | hydroxyethylthiazole kinase activity | molecular_function | Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H+. | [
"EC:2.7.1.50",
"RHEA:24212"
] | null | [
"4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity",
"ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity",
"hydroxyethylthiazole kinase (phosphorylating)"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.50",
"KEGG_REACTION:R04448",
"MetaCyc:THIAZOLSYN3-RXN",
"RHEA:24212"
] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.50",
"skos:exactMatch RHEA:24212",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004418 | 4,418 | hydroxymethylbilane synthase activity | molecular_function | Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4. | [
"EC:2.5.1.61",
"RHEA:13185"
] | null | [
"(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity",
"(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)",
"HMB-synthase activity",
"porphobilinogen ammonia-lyase (polymerizing)",
"porphobilinogen deaminase activity",
"porphobilinogen:(... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.5.1.61",
"KEGG_REACTION:R00084",
"MetaCyc:OHMETHYLBILANESYN-RXN",
"Reactome:R-HSA-189406 \"4 PBGs bind to form HMB\"",
"RHEA:13185"
] | [
"GO:0016765"
] | [] | [] | [] | [
"GO:0016765"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.5.1.61",
"skos:exactMatch RHEA:13185",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004419 | 4,419 | hydroxymethylglutaryl-CoA lyase activity | molecular_function | Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA. | [
"EC:4.1.3.4",
"RHEA:24404"
] | null | [
"(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)",
"(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity",
"3-hydroxy-3-methylglutarate-CoA lyase activity",
"3-hydroxy-3-methylglutaryl CoA cleaving enzyme",
"3-hydroxy-3-methylglutaryl coenzyme A lyase activity",
"3-hyd... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.1.3.4",
"KEGG_REACTION:R01360",
"MetaCyc:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN",
"Reactome:R-HSA-6788597 \"HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA\"",
"Reactome:R-HSA-74180 \"HMG CoA => acetoacetic acid + acetyl CoA\"",
"RHEA:24404"
] | [
"GO:0016833"
] | [] | [] | [] | [
"GO:0016833"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.3.4",
"skos:exactMatch RHEA:24404",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004420 | 4,420 | hydroxymethylglutaryl-CoA reductase (NADPH) activity | molecular_function | Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH. | [
"PMID:29224355",
"RHEA:15989"
] | null | [
"3-hydroxy-3-methylglutaryl-coenzyme A reductase activity",
"HMG-CoA reductase activity",
"hydroxymethylglutaryl-CoA reductase activity"
] | [
"BROAD",
"BROAD",
"RELATED"
] | [
"GO:0042282"
] | [] | [
"EC:1.1.1.34",
"KEGG_REACTION:R02082",
"MetaCyc:1.1.1.34-RXN",
"Reactome:R-HSA-191352 \"HMGCR dimer reduces bHMG-CoA to MVA\"",
"RHEA:15989"
] | [
"GO:0016616"
] | [] | [] | [] | [
"GO:0016616"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.34",
"skos:exactMatch RHEA:15989",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21411\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004422 | 4,422 | hypoxanthine phosphoribosyltransferase activity | molecular_function | Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. | [
"RHEA:17973"
] | null | [
"6-hydroxypurine phosphoribosyltransferase activity",
"6-mercaptopurine phosphoribosyltransferase activity",
"guanine-hypoxanthine phosphoribosyltransferase activity",
"HGPRTase activity",
"HPRT",
"hypoxanthine-guanine phosphoribosyltransferase activity",
"IMP diphosphorylase activity",
"IMP pyrophosp... | [
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD"
] | [] | [] | [
"KEGG_REACTION:R01132",
"MetaCyc:HYPOXANPRIBOSYLTRAN-RXN",
"RHEA:17973"
] | [
"GO:0106130"
] | [] | [] | [] | [
"GO:0106130"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:2.4.2.8",
"skos:exactMatch RHEA:17973"
] | null | null | false | true | 4 |
GO:0004423 | 4,423 | iduronate-2-sulfatase activity | molecular_function | Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin. | [
"EC:3.1.6.13"
] | null | [
"2-sulfo-L-iduronate 2-sulfatase activity",
"chondroitinsulfatase",
"iduronate sulfatase activity",
"iduronate sulfate sulfatase activity",
"iduronate-2-sulfate sulfatase activity",
"iduronate-2-sulphatase activity",
"iduronide-2-sulfate sulfatase activity",
"idurono-2-sulfatase activity",
"L-iduron... | [
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.1.6.13",
"MetaCyc:3.1.6.13-RXN",
"Reactome:R-HSA-1678650 \"IDS hydrolyses Heparan sulfate chain(5)\"",
"Reactome:R-HSA-1793182 \"IDS hydrolyses dermatan sulfate (Chebi:63517 chain)\"",
"Reactome:R-HSA-2262743 \"Defective IDS does not hydrolyse dermatan sulfate (Chebi:63517 chain)\"",
"Reactome:R-HSA... | [
"GO:0008484"
] | [] | [] | [] | [
"GO:0008484"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.6.13",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004424 | 4,424 | imidazoleglycerol-phosphate dehydratase activity | molecular_function | Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. | [
"EC:4.2.1.19",
"RHEA:11040"
] | null | [
"D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]",
"D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity",
"IGP dehydratase activity",
"imidazoleglycerol phosphate dehydratase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:4.2.1.19",
"KEGG_REACTION:R03457",
"MetaCyc:IMIDPHOSDEHYD-RXN",
"RHEA:11040"
] | [
"GO:0016836"
] | [] | [] | [] | [
"GO:0016836"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.2.1.19",
"skos:exactMatch RHEA:11040",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004425 | 4,425 | indole-3-glycerol-phosphate synthase activity | molecular_function | Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O. | [
"EC:4.1.1.48"
] | null | [
"1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)",
"1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]",
"indole-3-glycerophosphate synthase activity",
"indoleglycerol phosphate synthase activity",
... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.1.1.48",
"MetaCyc:IGPSYN-RXN",
"RHEA:23476"
] | [
"GO:0016831"
] | [] | [] | [] | [
"GO:0016831"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.1.48",
"skos:exactMatch RHEA:23476",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004427 | 4,427 | inorganic diphosphate phosphatase activity | molecular_function | Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate. | [
"EC:3.6.1.1",
"RHEA:24576"
] | null | [
"diphosphate phosphohydrolase activity",
"inorganic diphosphatase activity",
"inorganic pyrophosphatase activity",
"pyrophosphate phosphohydrolase activity"
] | [
"RELATED",
"EXACT",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.6.1.1",
"KEGG_REACTION:R00004",
"MetaCyc:INORGPYROPHOSPHAT-RXN",
"Reactome:R-HSA-449937 \"pyrophosphate + H2O => 2 orthophosphate [mitochondrial]\"",
"Reactome:R-HSA-6788912 \"LHPP:Mg2+ dimer hydrolyses PPi\"",
"Reactome:R-HSA-71732 \"PPA1 hydrolyzes pyrophosphate to orthophosphate\"",
"RHEA:24576... | [
"GO:0016462"
] | [] | [] | [] | [
"GO:0016462"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.6.1.1",
"skos:exactMatch RHEA:24576",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23401\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004428 | 4,428 | obsolete inositol or phosphatidylinositol kinase activity | molecular_function | OBSOLETE. Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. | [
"GOC:hb"
] | This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids. | [
"inositol or phosphatidylinositol kinase activity",
"inositol/phosphatidylinositol kinase activity"
] | [
"EXACT",
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0019140",
"GO:0052742"
] | [] | null | null | true | true | 2 |
GO:0004430 | 4,430 | 1-phosphatidylinositol 4-kinase activity | molecular_function | Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+. | [
"EC:2.7.1.67",
"RHEA:19877"
] | null | [
"phosphatidylinositol 4-kinase activity",
"phosphatidylinositol kinase (phosphorylating) activity",
"phosphatidylinositol kinase activity",
"PI 4-kinase activity",
"PI kinase activity",
"PI4-kinase activity",
"PI4K",
"PI4K-alpha activity",
"PtdIns-4-kinase activity",
"type II phosphatidylinositol ... | [
"EXACT",
"BROAD",
"BROAD",
"EXACT",
"BROAD",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:2.7.1.67",
"KEGG_REACTION:R03361",
"MetaCyc:1-PHOSPHATIDYLINOSITOL-KINASE-RXN",
"Reactome:R-HSA-1675780 \"PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane\"",
"Reactome:R-HSA-1675813 \"PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane\"",
"Reactome:R-HSA-1675883 \"PI is phosph... | [
"GO:0052742"
] | [] | [] | [] | [
"GO:0052742"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.67",
"skos:exactMatch RHEA:19877",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28336\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004433 | 4,433 | obsolete 1-phosphatidylinositol-4-phosphate kinase, class IB | molecular_function | OBSOLETE. A class I PI3K activated via heterotrimeric G-proteins. | [
"PMID:11050418"
] | This term was made obsolete because it is not a valid molecular function. | [
"1-phosphatidylinositol-4-phosphate kinase, class IB"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0016308"
] | [] | null | null | true | true | 3 |
GO:0004435 | 4,435 | phosphatidylinositol-4,5-bisphosphate phospholipase C activity | molecular_function | Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+. | [
"RHEA:33179"
] | null | [
"1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity",
"1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity",
"1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity",
"monophosphatidylinositol phosphodiesterase activity",
"phosp... | [
"RELATED",
"RELATED",
"EXACT",
"BROAD",
"BROAD",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"BROAD"
] | [] | [] | [
"EC:3.1.4.11",
"KEGG_REACTION:R03435",
"MetaCyc:3.1.4.11-RXN",
"Reactome:R-HSA-111879 \"PIP2 hydrolysis\"",
"Reactome:R-HSA-167686 \"Active PLCG1 hydrolyses PIP2\"",
"Reactome:R-HSA-1855177 \"PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane\"",
"Reactome:R-HSA-185... | [
"GO:0004629"
] | [] | [] | [] | [
"GO:0004629"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.4.11",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29643\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30949\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004436 | 4,436 | phosphatidylinositol diacylglycerol-lyase activity | molecular_function | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol. | [
"EC:4.6.1.13"
] | null | [
"1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)",
"1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)",
"1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)",
"1-phosphatidylinositol phosphodi... | [
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"BROAD"
] | [] | [] | [
"EC:4.6.1.13",
"MetaCyc:3.1.4.10-RXN",
"RHEA:17093"
] | [
"GO:0016849"
] | [] | [] | [] | [
"GO:0016849"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.6.1.13",
"skos:exactMatch RHEA:17093",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004437 | 4,437 | obsolete inositol or phosphatidylinositol phosphatase activity | molecular_function | OBSOLETE. Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. | [
"GOC:hb"
] | This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids. | [
"inositol or phosphatidylinositol phosphatase activity",
"inositol/phosphatidylinositol phosphatase activity"
] | [
"EXACT",
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0034593",
"GO:0034594",
"GO:0052744",
"GO:0052745"
] | [] | null | null | true | true | 8 |
GO:0004438 | 4,438 | phosphatidylinositol-3-phosphate phosphatase activity | molecular_function | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate. | [
"EC:3.1.3.64"
] | Note that this function includes EC:3.1.3.65. | [
"1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity",
"D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity",
"inositol 1,3-bisphosphate phosphatase activity",
"inositol-1,3-bisphosphate 3-phosphatase activity",
"inositol-polyphosphate 3-phosphatase activity",
"phosphatidyl-3-ph... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [
"GO:0016315"
] | [] | [
"EC:3.1.3.64",
"MetaCyc:PHOSPHATIDYLINOSITOL-3-PHOSPHATASE-RXN",
"Reactome:R-HSA-1675795 \"PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane\"",
"Reactome:R-HSA-1675994 \"PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane\"",
"Reactome:R-HSA-1676114 \"PI3P is depho... | [
"GO:0052744"
] | [] | [] | [] | [
"GO:0052744"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.3.64",
"skos:exactMatch RHEA:12316",
"skos:narrowMatch RHEA:42328",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24252\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004439 | 4,439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | molecular_function | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. | [
"RHEA:22764"
] | null | [
"phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity",
"phosphatidylinositol 4,5-bisphosphate phosphatase activity",
"phosphatidylinositol-bisphosphatase activity",
"PI(4,5)P2 5-phosphatase activity",
"PtdIns(4,5)P(2) 5-phosphatase activity",
"PtdIns(4,5)P2 5-phosphatase activity",
"triphosp... | [
"RELATED",
"BROAD",
"BROAD",
"EXACT",
"RELATED",
"RELATED",
"BROAD",
"BROAD"
] | [
"GO:0001668"
] | [] | [
"EC:3.1.3.36",
"KEGG_REACTION:R04404",
"MetaCyc:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN",
"Reactome:R-HSA-1675824 \"PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane\"",
"Reactome:R-HSA-1676177 \"PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane\"",
"Re... | [
"GO:0034595",
"GO:0106019"
] | [] | [] | [] | [
"GO:0034595",
"GO:0106019"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.3.36",
"skos:exactMatch RHEA:22764",
"skos:narrowMatch RHEA:43576",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004441 | 4,441 | inositol-1,4-bisphosphate 1-phosphatase activity | molecular_function | Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate. | [
"EC:3.1.3.57",
"GOC:hb"
] | null | [
"1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity",
"inositol polyphosphate 1-phosphatase activity",
"inositol-polyphosphate 1-phosphatase activity"
] | [
"RELATED",
"BROAD",
"RELATED"
] | [] | [] | [
"EC:3.1.3.57",
"MetaCyc:3.1.3.57-RXN",
"Reactome:R-HSA-1855208 \"I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol\"",
"RHEA:15553"
] | [
"GO:0016312"
] | [] | [] | [] | [
"GO:0016312"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.3.57",
"skos:exactMatch RHEA:15553",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004442 | 4,442 | obsolete inositol-1,4,-bisphosphate 3-phosphatase | molecular_function | OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate. | [
"EC:3.1.3.65",
"GOC:curators"
] | null | [
"inositol-1,4,-bisphosphate 3-phosphatase"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004438"
] | [] | null | null | true | true | 3 |
GO:0004443 | 4,443 | obsolete inositol-1,4,-bisphosphate 4-phosphatase | molecular_function | OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate. | [
"EC:3.1.3.66",
"GOC:curators"
] | null | [
"inositol-1,4,-bisphosphate 4-phosphatase"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0016316"
] | [] | null | null | true | true | 6 |
GO:0004444 | 4,444 | obsolete inositol-1,4,5-trisphosphate 1-phosphatase | molecular_function | OBSOLETE. The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate. | [
"EC:3.1.3.61",
"GOC:hb"
] | This term was made obsolete because the existence of this function has not been established. | [
"inositol-1,4,5-trisphosphate 1-phosphatase"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0046030"
] | [] | null | null | true | true | 3 |
GO:0004445 | 4,445 | inositol-polyphosphate 5-phosphatase activity | molecular_function | Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. | [
"EC:3.1.3.56"
] | Note that this is a compound function and should be replaced by 'GO:0052659 : inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity' and 'GO:0052658 : inositol-1,4,5-trisphosphate 5-phosphatase activity'. | [
"1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity",
"5PTase activity",
"D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity",
"D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity",
"D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity",
"inosine triphosphatase act... | [
"NARROW",
"RELATED",
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"NARROW",
"NARROW",
"RELATED",
"NARROW",
"NARROW",
"BROAD",
"NARROW",
"RELATED",
"RELATED",
"NARROW"
] | [] | [] | [
"EC:3.1.3.56"
] | [
"GO:0046030"
] | [] | [] | [] | [
"GO:0046030"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.3.56",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28070\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004446 | 4,446 | inositol hexakisphosphate phosphatase activity | molecular_function | Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate + phosphate. | [
"GOC:curators"
] | null | [] | [] | [] | [] | [] | [
"GO:0052745"
] | [] | [] | [] | [
"GO:0052745"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25949\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004447 | 4,447 | iodide peroxidase activity | molecular_function | Catalysis of the reactions: (1) 2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O; (2) [thyroglobulin]-L-tyrosine + iodide + H2O2 + H+ = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O; (3) [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 + H+ = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O; (4) 2 [thyroglobulin]-3,5-diiodo-L-tyros... | [
"EC:1.11.1.8",
"PMID:8651700"
] | null | [
"iodinase activity",
"thyroid peroxidase activity",
"thyroperoxidase activity",
"TPO activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.11.1.8",
"MetaCyc:IODIDE-PEROXIDASE-RXN",
"RHEA:23336",
"RHEA:48956",
"RHEA:48960",
"RHEA:48964",
"RHEA:48968"
] | [
"GO:0140905"
] | [] | [] | [] | [
"GO:0140905"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.11.1.8",
"skos:narrowMatch RHEA:23336",
"skos:narrowMatch RHEA:48956",
"skos:narrowMatch RHEA:48960",
"skos:narrowMatch RHEA:48964",
"skos:narrowMatch RHEA:48968",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21027\" xsd:anyURI",
"term_tracker_item \"ht... | null | null | false | true | 4 |
GO:0004448 | 4,448 | isocitrate dehydrogenase [NAD(P)+] activity | molecular_function | Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H. | [
"GOC:curators"
] | null | [
"IDH activity",
"IDP activity",
"isocitrate dehydrogenase activity",
"isocitric acid dehydrogenase activity",
"isocitric dehydrogenase activity",
"oxalosuccinate carboxylase activity",
"oxalosuccinate decarboxylase activity",
"oxalosuccinic decarboxylase activity"
] | [
"RELATED",
"RELATED",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [
"gocheck_do_not_annotate"
] | [] | [
"GO:0016616"
] | [] | [] | [] | [
"GO:0016616"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23235\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004449 | 4,449 | isocitrate dehydrogenase (NAD+) activity | molecular_function | Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH. | [
"RHEA:23632"
] | null | [
"isocitrate dehydrogenase (NAD) activity",
"isocitrate:NAD+ oxidoreductase (decarboxylating)",
"NAD dependent isocitrate dehydrogenase activity",
"NAD isocitrate dehydrogenase activity",
"NAD isocitric dehydrogenase activity",
"NAD-linked isocitrate dehydrogenase activity",
"NAD-specific isocitrate dehy... | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [
"EC:1.1.1.41",
"Reactome:R-HSA-70967 \"IDH3 complex decarboxylates isocitrate\"",
"RHEA:23632"
] | [
"GO:0004448"
] | [] | [] | [] | [
"GO:0004448"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch MetaCyc:ISOCITRATE-DEHYDROGENASE-NAD+-RXN",
"skos:exactMatch EC:1.1.1.41",
"skos:exactMatch RHEA:23632",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23235\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28176\" xsd:anyURI",
... | null | null | false | true | 1 |
GO:0004450 | 4,450 | isocitrate dehydrogenase (NADP+) activity | molecular_function | Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. | [
"RHEA:19629"
] | null | [
"dual-cofactor-specific isocitrate dehydrogenase activity",
"isocitrate (NADP) dehydrogenase activity",
"isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity",
"isocitrate dehydrogenase (NADP) activity",
"isocitrate dehydrogenase (NADP-dependent) activity",
"isocitrate:NADP+ oxi... | [
"RELATED",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [
"EC:1.1.1.42",
"MetaCyc:ISOCITDEH-RXN",
"Reactome:R-HSA-389540 \"isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+\"",
"Reactome:R-HSA-389550 \"isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+\"",
"Reactome:R-HSA-450984 \"IDH2 dimer decarboxylates isocitrate\"",
"RHEA:19629"
] | [
"GO:0004448"
] | [] | [] | [] | [
"GO:0004448"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.42",
"skos:exactMatch RHEA:19629",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23235\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004451 | 4,451 | isocitrate lyase activity | molecular_function | Catalysis of the reaction: isocitrate = glyoxylate + succinate. | [
"EC:4.1.3.1",
"RHEA:13245"
] | null | [
"ICL activity",
"isocitrase activity",
"isocitratase activity",
"isocitrate glyoxylate-lyase (succinate-forming)",
"isocitrate glyoxylate-lyase activity",
"isocitritase activity",
"threo-DS-isocitrate glyoxylate-lyase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.1.3.1",
"KEGG_REACTION:R00479",
"MetaCyc:ISOCIT-CLEAV-RXN",
"RHEA:13245"
] | [
"GO:0016833"
] | [] | [] | [] | [
"GO:0016833"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.3.1",
"skos:exactMatch RHEA:13245",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004452 | 4,452 | isopentenyl-diphosphate delta-isomerase activity | molecular_function | Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate. | [
"RHEA:23284"
] | null | [
"IPP isomerase activity",
"isopentenyl-diphosphate D-isomerase activity",
"isopentenyl-diphosphate delta3-delta2-isomerase activity",
"isopentenylpyrophosphate delta-isomerase activity",
"isopentenylpyrophosphate isomerase activity",
"methylbutenylpyrophosphate isomerase activity"
] | [
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:5.3.3.2",
"KEGG_REACTION:R01123",
"MetaCyc:IPPISOM-RXN",
"Reactome:R-HSA-191382 \"Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate\"",
"RHEA:23284"
] | [
"GO:0016863"
] | [] | [] | [] | [
"GO:0016863"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.3.3.2",
"skos:exactMatch RHEA:23284",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004453 | 4,453 | juvenile-hormone esterase activity | molecular_function | Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone. | [
"PMID:11267890",
"RHEA:16393"
] | null | [
"JH esterase activity",
"JH-esterase activity",
"juvenile hormone analog esterase activity",
"juvenile hormone carboxyesterase activity",
"methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [
"goslim_chembl"
] | [
"EC:3.1.1.59",
"MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN",
"RHEA:16393"
] | [
"GO:0052689"
] | [] | [] | [] | [
"GO:0052689"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.1.59",
"skos:exactMatch RHEA:16393",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004454 | 4,454 | ketohexokinase activity | molecular_function | Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate. | [
"EC:2.7.1.3"
] | null | [
"ATP:D-fructose 1-phosphotransferase activity",
"hepatic fructokinase activity",
"ketohexokinase (phosphorylating)"
] | [
"RELATED",
"NARROW",
"RELATED"
] | [] | [] | [
"EC:2.7.1.3",
"MetaCyc:KETOHEXOKINASE-RXN",
"Reactome:R-HSA-5656459 \"Defective KHK does not phosphorylate beta-D-fructose\"",
"Reactome:R-HSA-70333 \"KHK dimer phosphorylates Fru to Fru 1-P\"",
"RHEA:18145"
] | [
"GO:0016773",
"GO:0019200"
] | [] | [] | [] | [
"GO:0016773",
"GO:0019200"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.3",
"skos:exactMatch RHEA:18145",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004455 | 4,455 | ketol-acid reductoisomerase activity | molecular_function | Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. | [
"EC:1.1.1.86"
] | null | [
"(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)",
"2-hydroxy-3-keto acid reductoisomerase activity",
"acetohydroxy acid isomeroreductase activity",
"acetohydroxy acid reductoisomerase activity",
"acetolactate reductoisomerase activity",
"alpha-keto-beta-hydroxylacyl reductoisomeras... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.1.1.86",
"MetaCyc:ACETOLACTREDUCTOISOM-RXN",
"RHEA:22068"
] | [
"GO:0016616"
] | [] | [] | [] | [
"GO:0016616"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.86",
"skos:exactMatch RHEA:22068",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004456 | 4,456 | phosphogluconate dehydratase activity | molecular_function | Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O. | [
"EC:4.2.1.12",
"RHEA:17277"
] | null | [
"6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)",
"6-phospho-D-gluconate hydro-lyase activity",
"6-phosphogluconate dehydrase activity",
"6-phosphogluconate dehydratase activity",
"6-phosphogluconic dehydrase activity",
"gluconate 6-phosphate dehydratase activity",
"... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.2.1.12",
"KEGG_REACTION:R02036",
"MetaCyc:PGLUCONDEHYDRAT-RXN",
"RHEA:17277"
] | [
"GO:0016836"
] | [] | [] | [] | [
"GO:0016836"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.2.1.12",
"skos:exactMatch RHEA:17277",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004457 | 4,457 | lactate dehydrogenase activity | molecular_function | Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate. | [
"GOC:ai",
"GOC:bf"
] | null | [] | [] | [] | [] | [] | [
"GO:0016614"
] | [] | [] | [] | [
"GO:0016614"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 3 |
GO:0004458 | 4,458 | D-lactate dehydrogenase (cytochrome) activity | molecular_function | Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate. | [
"RHEA:13521"
] | null | [
"(R)-lactate:ferricytochrome-c 2-oxidoreductase activity",
"cytochrome-dependent D-(-)-lactate dehydrogenase activity",
"D-(-)-lactic cytochrome c reductase activity",
"D-lactate (cytochrome) dehydrogenase activity",
"D-lactate dehydrogenase activity",
"D-lactate ferricytochrome c oxidoreductase activity"... | [
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"BROAD"
] | [] | [] | [
"EC:1.1.2.4",
"MetaCyc:D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN",
"RHEA:13521"
] | [
"GO:0016898",
"GO:0047809"
] | [] | [] | [] | [
"GO:0016898",
"GO:0047809"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.2.4",
"skos:exactMatch RHEA:13521",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
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