go_id string | go_numeric_id int64 | name string | namespace string | definition string | definition_xrefs list | comment string | synonyms list | synonym_scopes list | alt_ids list | subsets list | xrefs list | is_a_ids list | relationship_edges list | relationship_types list | relationship_target_ids list | parent_ids list | intersection_of list | union_of list | disjoint_from list | replaced_by list | consider list | property_values list | created_by string | creation_date string | is_obsolete bool | in_go_basic bool | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GO:0004459 | 4,459 | L-lactate dehydrogenase (NAD+) activity | molecular_function | Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. | [
"RHEA:23444"
] | null | [
"L-lactate dehydrogenase activity",
"L-lactic acid dehydrogenase activity",
"L-lactic dehydrogenase activity"
] | [
"BROAD",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.1.1.27",
"MetaCyc:L-LACTATE-DEHYDROGENASE-RXN",
"Reactome:R-HSA-6807826 \"LDHAL6B reduces PYR to LACT\"",
"Reactome:R-HSA-70510 \"LDH tetramer oxidises LACT to PYR\"",
"Reactome:R-HSA-71849 \"LDH tetramer reduces PYR to LACT\"",
"RHEA:23444"
] | [
"GO:0102443",
"GO:0140171"
] | [] | [] | [] | [
"GO:0102443",
"GO:0140171"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.27",
"skos:exactMatch RHEA:23444",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30132\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004460 | 4,460 | L-lactate dehydrogenase (cytochrome) activity | molecular_function | Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate. | [
"RHEA:19909"
] | null | [
"(S)-lactate:ferricytochrome-c 2-oxidoreductase activity",
"cytochrome b2",
"cytochrome b2 (flavin-free derivative of flavocytochrome b2)",
"dehydrogenase, lactate (cytochrome)",
"flavocytochrome b2",
"L(+)-lactate:cytochrome c oxidoreductase activity",
"L-lactate cytochrome c oxidoreductase activity",
... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"BROAD",
"RELATED"
] | [] | [] | [
"EC:1.1.2.3",
"MetaCyc:L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN",
"RHEA:19909"
] | [
"GO:0016898",
"GO:0140171"
] | [] | [] | [] | [
"GO:0016898",
"GO:0140171"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.2.3",
"skos:exactMatch RHEA:19909",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004461 | 4,461 | lactose synthase activity | molecular_function | Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose. | [
"EC:2.4.1.22"
] | null | [
"lactose synthetase activity",
"UDP-galactose-glucose galactosyltransferase activity",
"UDP-galactose:D-glucose 4-beta-D-galactotransferase activity",
"UDPgalactose-glucose galactosyltransferase activity",
"UDPgalactose:D-glucose 4-beta-D-galactotransferase activity",
"uridine diphosphogalactose-glucose g... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.1.22",
"MetaCyc:LACTOSE-SYNTHASE-RXN",
"Reactome:R-HSA-5653878 \"B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac\"",
"RHEA:12404"
] | [
"GO:0035250"
] | [] | [] | [] | [
"GO:0035250"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.22",
"skos:exactMatch RHEA:12404",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004462 | 4,462 | lactoylglutathione lyase activity | molecular_function | Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. | [
"EC:4.4.1.5",
"RHEA:19069"
] | null | [
"(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity",
"(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)",
"aldoketomutase activity",
"glyoxalase I activity",
"glyoxylase I",
"ketone-aldehyde mutase activity",
"methylglyoxalase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.4.1.5",
"KEGG_REACTION:R02530",
"MetaCyc:GLYOXI-RXN",
"Reactome:R-HSA-5694071 \"GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH\"",
"RHEA:19069"
] | [
"GO:0016846"
] | [] | [] | [] | [
"GO:0016846"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.4.1.5",
"skos:exactMatch RHEA:19069",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004463 | 4,463 | leukotriene-A4 hydrolase activity | molecular_function | Catalysis of the reaction: H2O + leukotriene A(4) = leukotriene B(4). | [
"EC:3.3.2.6",
"RHEA:22324"
] | null | [
"(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity",
"leukotriene A(4) hydrolase activity",
"leukotriene A4 hydrolase activity",
"LTA-4 hydrolase activity",
"LTA4 hydrolase activity",
"LTA4H"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.3.2.6",
"KEGG_REACTION:R03057",
"MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN",
"Reactome:R-HSA-266072 \"LTA4 is hydolysed to LTB4 by LTA4H\"",
"RHEA:22324"
] | [
"GO:0016803"
] | [] | [] | [] | [
"GO:0016803"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.3.2.6",
"skos:exactMatch RHEA:22324",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004465 | 4,465 | lipoprotein lipase activity | molecular_function | Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein. May also hydrolyze diacylglycerol and phospholipids present in lipoproteins. | [
"EC:3.1.1.34",
"GOC:bf"
] | null | [
"clearing factor lipase activity",
"diacylglycerol hydrolase activity",
"diacylglycerol lipase activity",
"diglyceride lipase activity",
"lipemia-clearing factor",
"postheparin esterase activity",
"postheparin lipase activity",
"triacylglycero-protein acylhydrolase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.1.1.34",
"Reactome:R-HSA-1482811 \"DAG is hydrolyzed to 2-MAG by PNPLA2/3\"",
"Reactome:R-HSA-174757 \"chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols\"",
"Reactome:R-HSA-2395768 \"LPL hydrolyses TGs from mature CMs\"",
"Reactome:R-HSA-6789310 \"LIPs hydrolyse T... | [
"GO:0004806"
] | [] | [] | [] | [
"GO:0004806"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.1.34",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28176\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28339\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004466 | 4,466 | long-chain fatty acyl-CoA dehydrogenase activity | molecular_function | Catalysis of the reaction: a long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. | [
"RHEA:17721"
] | While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). | [
"long-chain acyl-coenzyme A dehydrogenase activity",
"long-chain-acyl-CoA dehydrogenase activity",
"palmitoyl-CoA dehydrogenase activity",
"palmitoyl-coenzyme A dehydrogenase activity"
] | [
"RELATED",
"EXACT",
"NARROW",
"NARROW"
] | [] | [] | [
"EC:1.3.8.8",
"MetaCyc:LONG-CHAIN-ACYL-COA-DEHYDROGENASE-RXN",
"RHEA:17721",
"RHEA:43448",
"RHEA:47228",
"RHEA:47236",
"RHEA:47240",
"RHEA:47300",
"RHEA:47304",
"RHEA:47316",
"RHEA:47432",
"RHEA:47448",
"RHEA:48188",
"RHEA:82939",
"RHEA:83023",
"RHEA:83055",
"RHEA:83155",
"RHEA:831... | [
"GO:0003995"
] | [] | [] | [] | [
"GO:0003995"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.3.8.8",
"skos:exactMatch RHEA:17721",
"skos:narrowMatch RHEA:43448",
"skos:narrowMatch RHEA:47228",
"skos:narrowMatch RHEA:47236",
"skos:narrowMatch RHEA:47240",
"skos:narrowMatch RHEA:47300",
"skos:narrowMatch RHEA:47304",
"skos:narrowMatch RHEA:47316",
"skos:narrowMatch RHE... | null | null | false | true | 5 |
GO:0004467 | 4,467 | long-chain fatty acid-CoA ligase activity | molecular_function | Catalysis of the reaction: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. | [
"RHEA:15421"
] | While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). | [
"acyl-activating enzyme activity",
"acyl-CoA ligase activity",
"acyl-CoA synthetase activity",
"fatty acid thiokinase (long-chain) activity",
"LCFA synthetase activity",
"lignoceroyl-CoA synthase activity",
"long chain fatty acyl-CoA synthetase activity",
"long-chain acyl CoA synthetase activity",
"... | [
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"EXACT",
"NARROW",
"NARROW",
"RELATED"
] | [
"GO:0003996"
] | [] | [
"EC:6.2.1.3",
"MetaCyc:RXN-7904",
"Reactome:R-HSA-159425 \"Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)\"",
"Reactome:R-HSA-192137 \"THCA is conjugated with Coenzyme A (SLC27A5 BACS)\"",
"Reactome:R-HSA-193401 \"THCA is conjugated with Coenzyme A (SLC27A2 VLCS)\"",
... | [
"GO:0120515"
] | [
"part_of GO:0001676"
] | [
"part_of"
] | [
"GO:0001676"
] | [
"GO:0001676",
"GO:0120515"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.2.1.3",
"skos:exactMatch MetaCyc:RXN-7904",
"skos:exactMatch RHEA:15421",
"skos:narrowMatch RHEA:30751",
"skos:narrowMatch RHEA:33607",
"skos:narrowMatch RHEA:33615",
"skos:narrowMatch RHEA:33619",
"skos:narrowMatch RHEA:33635",
"skos:narrowMatch RHEA:33643",
"skos:narrowMatc... | null | null | false | true | 1 |
GO:0004468 | 4,468 | L-lysine N6-acetyltransferase activity, acting on acetyl phosphate as donor | molecular_function | Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine. | [
"RHEA:14417"
] | null | [
"acetyl-phosphate:L-lysine 6-N-acetyltransferase activity",
"acetyl-phosphate:L-lysine N6-acetyltransferase activity",
"LAT activity",
"lysine acetyltransferase activity",
"lysine N(6)-acetyltransferase activity",
"lysine N-acetyltransferase activity, acting on acetyl phosphate as donor",
"lysine N6-ace... | [
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:2.3.1.32",
"MetaCyc:LYSINE-N-ACETYLTRANSFERASE-RXN",
"Reactome:R-HSA-5618328 \"ATAT acetylates microtubules\"",
"Reactome:R-HSA-5693001 \"NAT8,8B acetylate BACE1\"",
"RHEA:14417"
] | [
"GO:0140085"
] | [] | [] | [] | [
"GO:0140085"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.32",
"skos:exactMatch RHEA:14417",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004470 | 4,470 | malic enzyme activity | molecular_function | Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. | [
"ISBN:0198506732"
] | null | [
"pyruvic-malic carboxylase activity"
] | [
"RELATED"
] | [] | [] | [] | [
"GO:0016615"
] | [] | [] | [] | [
"GO:0016615"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 3 |
GO:0004471 | 4,471 | malate dehydrogenase (decarboxylating) (NAD+) activity | molecular_function | Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. | [
"RHEA:12653"
] | For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.38), see 'oxaloacetate decarboxylase activity ; GO:0008948'. | [
"'malic' enzyme",
"(S)-malate:NAD+ oxidoreductase (decarboxylating)",
"(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)",
"malate dehydrogenase (decarboxylating) activity",
"malate dehydrogenase (oxaloacetate-decarboxylating) activity",
"NAD-linked malic enzyme",
"NAD-malic enzyme activity"... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"BROAD",
"RELATED"
] | [
"GO:0004472",
"GO:0016619"
] | [] | [
"EC:1.1.1.39",
"KEGG_REACTION:R00214",
"MetaCyc:1.1.1.39-RXN",
"Reactome:R-HSA-9012268 \"ME2 tetramer decarboxylates MAL to PYR\"",
"RHEA:12653"
] | [
"GO:0004470",
"GO:0016616"
] | [] | [] | [] | [
"GO:0004470",
"GO:0016616"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:1.1.1.38",
"skos:exactMatch EC:1.1.1.39",
"skos:exactMatch MetaCyc:1.1.1.39-RXN",
"skos:exactMatch RHEA:12653",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28245\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28514\" x... | null | null | false | true | 5 |
GO:0004473 | 4,473 | malate dehydrogenase (decarboxylating) (NADP+) activity | molecular_function | Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH. | [
"RHEA:18253"
] | For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.40), see 'oxaloacetate decarboxylase activity ; GO:0008948'. | [
"'malic' enzyme",
"(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)",
"L-malate:NADP oxidoreductase activity",
"malate dehydrogenase (decarboxylating, NADP)",
"malate dehydrogenase (NADP, decarboxylating)",
"NADP-linked decarboxylating malic enzyme",
"NADP-malic enzyme activity",
"NADP-s... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.1.1.40",
"KEGG_REACTION:R00216",
"MetaCyc:MALIC-NADP-RXN",
"Reactome:R-HSA-9012036 \"ME1 tetramer decarboxylates MAL to PYR\"",
"Reactome:R-HSA-9012349 \"ME3 tetramer decarboxylates MAL to PYR\"",
"RHEA:18253"
] | [
"GO:0004470",
"GO:0016616"
] | [] | [] | [] | [
"GO:0004470",
"GO:0016616"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.40",
"skos:exactMatch MetaCyc:MALIC-NADP-RXN",
"skos:exactMatch RHEA:18253",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28245\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004474 | 4,474 | malate synthase activity | molecular_function | Catalysis of the reaction: acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H+. | [
"RHEA:18181"
] | null | [
"acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)",
"glyoxylate transacetase activity",
"glyoxylate transacetylase activity",
"glyoxylic transacetase activity",
"L-malate glyoxylate-lyase (CoA-acetylating) activity",
"malate condensing enzyme activity",
"malate sy... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.3.3.9",
"KEGG_REACTION:R00472",
"MetaCyc:MALSYN-RXN",
"RHEA:18181"
] | [
"GO:0046912"
] | [] | [] | [] | [
"GO:0046912"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.3.9",
"skos:exactMatch RHEA:18181",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004475 | 4,475 | mannose-1-phosphate guanylyltransferase (GTP) activity | molecular_function | Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose. | [
"RHEA:15229"
] | null | [
"GDP-mannose pyrophosphorylase activity",
"GTP-mannose-1-phosphate guanylyltransferase activity",
"GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity",
"GTP:mannose-1-phosphate guanylyltransferase activity",
"guanosine 5'-diphospho-D-mannose pyrophosphorylase activity",
"guanosine diphosphomanno... | [
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED"
] | [] | [] | [
"EC:2.7.7.13",
"KEGG_REACTION:R00885",
"MetaCyc:2.7.7.13-RXN",
"Reactome:R-HSA-446221 \"GMPPB converts Mannose-1-phosphate to GDP-Mannose\"",
"RHEA:15229"
] | [
"GO:0070568"
] | [] | [] | [] | [
"GO:0070568"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.7.13",
"skos:exactMatch RHEA:15229",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23283\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004476 | 4,476 | mannose-6-phosphate isomerase activity | molecular_function | Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. | [
"RHEA:12356"
] | null | [
"D-mannose-6-phosphate aldose-ketose-isomerase activity",
"D-mannose-6-phosphate ketol-isomerase activity",
"mannose phosphate isomerase activity",
"phosphohexoisomerase activity",
"phosphohexomutase activity",
"phosphomannoisomerase activity",
"phosphomannose isomerase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:5.3.1.8",
"MetaCyc:MANNPISOM-RXN",
"Reactome:R-HSA-3781832 \"Defective MPI does not isomerize Fru6P to Man6P\"",
"Reactome:R-HSA-532549 \"MPI isomerises Fru6P to Man6P\"",
"RHEA:12356"
] | [
"GO:0016861"
] | [] | [] | [] | [
"GO:0016861"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.3.1.8",
"skos:exactMatch RHEA:12356",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004477 | 4,477 | methenyltetrahydrofolate cyclohydrolase activity | molecular_function | Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. | [
"EC:3.5.4.9"
] | null | [
"5,10-methenyl-THF cyclohydrolase activity",
"5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)",
"citrovorum factor cyclodehydrase activity",
"formyl-methenyl-methylenetetrahydrofolate synthetase (combined)"
] | [
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.4.9",
"MetaCyc:METHENYLTHFCYCLOHYDRO-RXN",
"Reactome:R-HSA-200661 \"MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG\"",
"Reactome:R-HSA-200740 \"5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate\"",
"Reactome:R-HSA-6801328 \"MTHFD2, D2L oxidise 5,10-methylene-THF to ... | [
"GO:0019238"
] | [] | [] | [] | [
"GO:0019238"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.4.9",
"skos:exactMatch RHEA:23700",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004478 | 4,478 | methionine adenosyltransferase activity | molecular_function | Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. | [
"EC:2.5.1.6"
] | null | [
"adenosylmethionine synthetase activity",
"AdoMet synthetase activity",
"ATP-methionine adenosyltransferase activity",
"ATP:L-methionine S-adenosyltransferase activity",
"methionine S-adenosyltransferase activity",
"methionine-activating enzyme",
"S-adenosyl-L-methionine synthetase activity",
"S-adeno... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.5.1.6",
"MetaCyc:S-ADENMETSYN-RXN",
"Reactome:R-HSA-174391 \"MAT1A multimers transfer Ado from ATP to L-Met\"",
"Reactome:R-HSA-5603087 \"Defective MAT1A does not transfer Ado from ATP to L-Met\"",
"Reactome:R-HSA-5603114 \"MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met\"",
"RHEA:21080"
] | [
"GO:0016765"
] | [] | [] | [] | [
"GO:0016765"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.5.1.6",
"skos:exactMatch RHEA:21080",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004479 | 4,479 | methionyl-tRNA formyltransferase activity | molecular_function | Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA. | [
"EC:2.1.2.9"
] | null | [
"10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity",
"conversion of met-tRNAf to fmet-tRNA",
"conversion of mitochondrial met-tRNAf to fmet-tRNA",
"formylmethionyl-transfer ribonucleic synthetase activity",
"methionyl ribonucleic formyltransferase activity",
"methionyl-transfer ribon... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [
"GO:0001718",
"GO:0070128"
] | [] | [
"EC:2.1.2.9",
"MetaCyc:METHIONYL-TRNA-FORMYLTRANSFERASE-RXN",
"Reactome:R-HSA-5389841 \"MTFMT formylates methionyl-tRNA\"",
"RHEA:24380"
] | [
"GO:0016742",
"GO:0140101"
] | [
"part_of GO:0006413",
"part_of GO:0071951"
] | [
"part_of",
"part_of"
] | [
"GO:0006413",
"GO:0071951"
] | [
"GO:0006413",
"GO:0016742",
"GO:0071951",
"GO:0140101"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.1.2.9",
"skos:exactMatch RHEA:24380",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004481 | 4,481 | methylene-fatty-acyl-phospholipid synthase activity | molecular_function | Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid. | [
"EC:2.1.1.16"
] | null | [
"cyclopropane synthetase activity",
"S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)",
"unsaturated-phospholipid methyltransferase activity"
] | [
"BROAD",
"RELATED",
"BROAD"
] | [] | [] | [
"EC:2.1.1.16",
"MetaCyc:2.1.1.16-RXN",
"RHEA:17549"
] | [
"GO:0008757"
] | [] | [] | [] | [
"GO:0008757"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.1.1.16",
"skos:exactMatch RHEA:17549",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004482 | 4,482 | mRNA 5'-cap (guanine-N7-)-methyltransferase activity | molecular_function | Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine. | [
"EC:2.1.1.56"
] | null | [
"guanine-7-methyltransferase activity",
"messenger ribonucleate guanine 7-methyltransferase activity",
"messenger RNA guanine 7-methyltransferase activity",
"S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity",
"S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.1.1.56",
"MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN",
"Reactome:R-HSA-77090 \"Methylation of GMP-cap by RNA Methyltransferase\"",
"Reactome:R-HSA-9684016 \"nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs\"",
"Reactome:R-HSA-9684017 \"nsp14 acts as a cap N7 methyltransferase to... | [
"GO:0008170",
"GO:0008174"
] | [
"part_of GO:0006370",
"part_of GO:0106005"
] | [
"part_of",
"part_of"
] | [
"GO:0006370",
"GO:0106005"
] | [
"GO:0006370",
"GO:0008170",
"GO:0008174",
"GO:0106005"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.1.1.56",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25788\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004483 | 4,483 | methyltransferase cap1 activity | molecular_function | Catalysis of the reaction: a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA or snRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA or snRNA + S-adenosyl-L-homocysteine + H+. This activity catalyzes the methylation of the ribose on the ... | [
"EC:2.1.1.57"
] | null | [
"messenger ribonucleate nucleoside 2'-methyltransferase activity",
"messenger RNA (nucleoside-2'-)-methyltransferase activity",
"mRNA (adenosine-2'-O-)-methyltransferase activity",
"mRNA (nucleoside-2'-O-)-methyltransferase activity",
"S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activi... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.1.1.57",
"MetaCyc:2.1.1.57-RXN",
"Reactome:R-HSA-9684030 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)\"",
"Reactome:R-HSA-9684032 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)\"",
"Reactome:R-HSA-9684033 \"nsp16... | [
"GO:0008171",
"GO:0008173"
] | [] | [] | [] | [
"GO:0008171",
"GO:0008173"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.1.1.57",
"skos:narrowMatch RHEA:67020",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27387\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004484 | 4,484 | mRNA guanylyltransferase activity | molecular_function | Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. | [
"EC:2.7.7.50"
] | null | [
"GTP--RNA guanylyltransferase activity",
"GTP:mRNA guanylyltransferase activity",
"messenger RNA guanylyltransferase activity",
"mRNA capping enzyme activity",
"protein lambda2"
] | [
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.7.50",
"MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN",
"Reactome:R-HSA-77081 \"Formation of the CE:GMP intermediate complex\"",
"Reactome:R-HSA-77083 \"Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA\"",
"Reactome:R-HSA-9815529 \"nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgeno... | [
"GO:0008192"
] | [] | [] | [] | [
"GO:0008192"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.7.50",
"skos:exactMatch RHEA:54592",
"skos:narrowMatch RHEA:60836",
"skos:narrowMatch RHEA:60844",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004485 | 4,485 | methylcrotonoyl-CoA carboxylase activity | molecular_function | Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H+ + phosphate. | [
"EC:6.4.1.4",
"RHEA:13589"
] | null | [
"3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)",
"beta-methylcrotonyl CoA carboxylase activity",
"beta-methylcrotonyl coenzyme A carboxylase activity",
"beta-methylcrotonyl-CoA carboxylase activity",
"MCCC activity",
"methylcrotonyl coenzyme A carboxylase activity",
"methylcrotonyl-CoA carbo... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.4.1.4",
"KEGG_REACTION:R04138",
"MetaCyc:METHYLCROTONYL-COA-CARBOXYLASE-RXN",
"Reactome:R-HSA-508308 \"beta-methylglutaconyl-CoA + ADP + orthophosphate <=> beta-methylcrotonyl-CoA + ATP + HCO3- (MCCA)\"",
"Reactome:R-HSA-70773 \"beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP... | [
"GO:0016421"
] | [] | [] | [] | [
"GO:0016421"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.4.1.4",
"skos:exactMatch RHEA:13589",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004486 | 4,486 | obsolete methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity | molecular_function | OBSOLETE. Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+. | [
"GOC:vw"
] | This term was obsoleted because it is an unnecessary grouping term. | [
"5,10-methylene-THF dehydrogenase activity",
"N5,N10-methylenetetrahydrofolate dehydrogenase activity"
] | [
"EXACT",
"RELATED"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004487",
"GO:0004488"
] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28070\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30105\" xsd:anyURI"
] | null | null | true | true | 2 |
GO:0004487 | 4,487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity | molecular_function | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH. | [
"RHEA:22892"
] | null | [
"5,10-methylenetetrahydrofolate dehydrogenase activity",
"5,10-methylenetetrahydrofolate:NAD+ oxidoreductase"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.5.1.15",
"KEGG_REACTION:R01218",
"MetaCyc:1.5.1.15-RXN",
"Reactome:R-HSA-6801462 \"MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF\"",
"RHEA:22892"
] | [
"GO:0016646"
] | [] | [] | [] | [
"GO:0016646"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.5.1.15",
"skos:exactMatch RHEA:22892",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004488 | 4,488 | methylenetetrahydrofolate dehydrogenase (NADP+) activity | molecular_function | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH. | [
"EC:1.5.1.5",
"RHEA:22812"
] | null | [
"5,10-methylenetetrahydrofolate:NADP oxidoreductase activity",
"5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.5.1.5",
"KEGG_REACTION:R01220",
"MetaCyc:METHYLENETHFDEHYDROG-NADP-RXN",
"Reactome:R-HSA-200644 \"5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+\"",
"Reactome:R-HSA-200718 \"MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG\"",
"RHEA:228... | [
"GO:0016646"
] | [] | [] | [] | [
"GO:0016646"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.5.1.5",
"skos:exactMatch RHEA:22812",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004489 | 4,489 | methylenetetrahydrofolate reductase [NAD(P)H] activity | molecular_function | Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+. | [
"EC:1.5.1.20",
"PMID:26872964"
] | null | [
"5,10-CH(2)-H(4)folate reductase activity",
"5,10-CH2-H4folate reductase activity",
"5,10-methylenetetrahydrofolate reductase (FADH(2)) activity",
"5,10-methylenetetrahydrofolate reductase (FADH) activity",
"5,10-methylenetetrahydrofolate reductase (FADH2) activity",
"5,10-methylenetetrahydrofolate reduct... | [
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"EXACT",
"RELATED",
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"BROAD",
"BROA... | [
"GO:0008702"
] | [] | [
"EC:1.5.1.20",
"KEGG_REACTION:R01224",
"KEGG_REACTION:R07168",
"MetaCyc:1.5.1.20-RXN",
"Reactome:R-HSA-200676 \"MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG\""
] | [
"GO:0016646"
] | [] | [] | [] | [
"GO:0016646"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.5.1.20",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004490 | 4,490 | methylglutaconyl-CoA hydratase activity | molecular_function | Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O. | [
"EC:4.2.1.18",
"RHEA:21536"
] | null | [
"(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)",
"(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity",
"3-methylglutaconyl CoA hydratase activity",
"methylglutaconase activity",
"methylglutaconyl coenzyme A hydratase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.2.1.18",
"KEGG_REACTION:R02085",
"MetaCyc:METHYLGLUTACONYL-COA-HYDRATASE-RXN",
"Reactome:R-HSA-70785 \"beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA\"",
"Reactome:R-HSA-9914271 \"AUH mutants don't synthesize 3-hydroxy-methylglutaryl-CoA\"",
"RHEA:21536"
] | [
"GO:0016836"
] | [] | [] | [] | [
"GO:0016836"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.2.1.18",
"skos:exactMatch RHEA:21536",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004491 | 4,491 | methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity | molecular_function | Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + hydrogencarbonate + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product. | [
"EC:1.2.1.27",
"PMID:2768248"
] | null | [
"methylmalonate-semialdehyde dehydrogenase (acylating) activity",
"MMSA dehydrogenase activity",
"MSDH activity"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.2.1.27",
"MetaCyc:1.2.1.27-RXN",
"Reactome:R-HSA-70893 \"methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+\"",
"RHEA:20804",
"RHEA:76615"
] | [
"GO:0016620"
] | [] | [] | [] | [
"GO:0016620"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.2.1.27",
"skos:narrowMatch RHEA:20804",
"skos:narrowMatch RHEA:76615",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25638\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https:... | null | null | false | true | 4 |
GO:0004492 | 4,492 | methyl/ethyl malonyl-CoA decarboxylase activity | molecular_function | Catalysis of the reaction: (S)-methylmalonyl-CoA + H+ = CO2 + propanoyl-CoA or (2S)-ethylmalonyl-CoA + H+ = butanoyl-CoA + CO2. | [
"PMID:22016388"
] | null | [
"(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity",
"(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)",
"(S)-methylmalonyl-CoA carboxy-lyase activity",
"ethylmalonyl-CoA decarboxylase activity",
"methylmalonyl-coenzyme A decarboxylase activity"
] | [
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW"
] | [] | [] | [
"EC:4.1.1.94",
"MetaCyc:METHYLMALONYL-COA-DECARBOXYLASE-RXN",
"RHEA:27666",
"RHEA:32131",
"RHEA:59540",
"RHEA:61340"
] | [
"GO:0016831"
] | [] | [] | [] | [
"GO:0016831"
] | [] | [] | [] | [] | [] | [
"skos:narrowMatch EC:4.1.1.94",
"skos:narrowMatch RHEA:27666",
"skos:narrowMatch RHEA:32131",
"skos:narrowMatch RHEA:59540",
"skos:narrowMatch RHEA:61340",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21629\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004493 | 4,493 | methylmalonyl-CoA epimerase activity | molecular_function | Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA. | [
"EC:5.1.99.1",
"RHEA:20553"
] | null | [
"2-methyl-3-oxopropanoyl-CoA 2-epimerase activity",
"DL-methylmalonyl-CoA racemase activity",
"methylmalonyl coenzyme A racemase activity",
"methylmalonyl-CoA 2-epimerase activity",
"methylmalonyl-CoA racemase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:5.1.99.1",
"KEGG_REACTION:R02765",
"MetaCyc:METHYLMALONYL-COA-EPIM-RXN",
"Reactome:R-HSA-71020 \"D-methylmalonyl-CoA <=> L-methylmalonyl-CoA\"",
"RHEA:20553"
] | [
"GO:0016854"
] | [] | [] | [] | [
"GO:0016854"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.1.99.1",
"skos:exactMatch RHEA:20553",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004494 | 4,494 | methylmalonyl-CoA mutase activity | molecular_function | Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA. | [
"EC:5.4.99.2",
"RHEA:22888"
] | null | [
"(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity",
"(R)-methylmalonyl-CoA CoA-carbonylmutase activity",
"(S)-methylmalonyl-CoA mutase activity",
"methylmalonyl coenzyme A carbonylmutase activity",
"methylmalonyl coenzyme A mutase activity",
"methylmalonyl-CoA CoA-carbonyl mutase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:5.4.99.2",
"KEGG_REACTION:R00833",
"MetaCyc:METHYLMALONYL-COA-MUT-RXN",
"Reactome:R-HSA-3322971 \"Defective MUT does not isomerise L-MM-CoA to SUCC-CoA\"",
"Reactome:R-HSA-71010 \"MUT isomerises L-MM-CoA to SUCC-CoA\"",
"RHEA:22888",
"UM-BBD_reactionID:r0922"
] | [
"GO:0016866"
] | [] | [] | [] | [
"GO:0016866"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.4.99.2",
"skos:exactMatch RHEA:22888",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004495 | 4,495 | obsolete mevaldate reductase activity | molecular_function | OBSOLETE. Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor. | [
"GOC:curators"
] | The reason for obsoletion is that this term was an unnecessary grouping term. | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27410\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28243\" xsd:anyURI"
] | null | null | true | true | 8 |
GO:0004496 | 4,496 | mevalonate kinase activity | molecular_function | Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H+. | [
"EC:2.7.1.36",
"RHEA:17065"
] | null | [
"ATP:(R)-mevalonate 5-phosphotransferase activity",
"ATP:mevalonate 5-phosphotransferase activity",
"mevalonate 5-phosphotransferase activity",
"mevalonate kinase (phosphorylating)",
"mevalonate phosphokinase activity",
"mevalonic acid kinase activity",
"mevalonic kinase activity",
"MVA kinase activit... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.36",
"KEGG_REACTION:R02245",
"MetaCyc:MEVALONATE-KINASE-RXN",
"Reactome:R-HSA-191380 \"Mevalonate is phosphorylated to mevalonate-5-phosphate\"",
"RHEA:17065"
] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.36",
"skos:exactMatch RHEA:17065",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004497 | 4,497 | monooxygenase activity | molecular_function | Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water. | [
"PMID:1444267"
] | null | [
"hydroxylase activity",
"mixed-function oxidase"
] | [
"RELATED",
"RELATED"
] | [] | [
"goslim_pir"
] | [
"Reactome:R-HSA-143468 \"MEOS oxidizes ethanol to acetaldehyde\"",
"Reactome:R-HSA-156526 \"CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO\"",
"Reactome:R-HSA-211882 \"CYP3A7 can 6beta-hydroxylate testosterone\"",
"Reactome:R-HSA-211904 \"CYP4F12 18-hydroxylates ARA\"",
"Reactome:R-HSA-211910 \"CYP2C8 inactivate... | [
"GO:0016491"
] | [] | [] | [] | [
"GO:0016491"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:1.-.-.-",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30165\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004498 | 4,498 | calcidiol 1-monooxygenase activity | molecular_function | Catalysis of the reaction: calcidiol + H+ + NADPH + O2 = calcitriol + H2O + NADP+. | [
"EC:1.14.15.18",
"RHEA:20573"
] | null | [
"1-hydroxylase-25-hydroxyvitamin D3 activity",
"25-hydroxy D3-1alpha-hydroxylase activity",
"25-hydroxy vitamin D3 1-alpha-hydroxylase activity",
"25-hydroxycholecalciferol 1-hydroxylase activity",
"25-hydroxycholecalciferol 1-monooxygenase activity",
"25-hydroxycholecalciferol 1alpha-hydroxylase activity... | [
"RELATED",
"RELATED",
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"NARROW"
] | [] | [] | [
"EC:1.14.15.18",
"KEGG_REACTION:R03610",
"MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN",
"Reactome:R-HSA-209868 \"CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D\"",
"Reactome:R-HSA-5602186 \"Defective CYP27B1 does not hydroxylate CDL\"",
"RHEA:20573"
] | [
"GO:0016709"
] | [
"part_of GO:0036378"
] | [
"part_of"
] | [
"GO:0036378"
] | [
"GO:0016709",
"GO:0036378"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.14.15.18",
"skos:exactMatch RHEA:20573",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004499 | 4,499 | N,N-dimethylaniline monooxygenase activity | molecular_function | Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. | [
"RHEA:24468"
] | null | [
"1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity",
"dimethylaniline monooxygenase (N-oxide-forming) activity",
"dimethylaniline N-oxidase activity",
"dimethylaniline oxidase activity",
"DMA oxidase activity",
"FAD-containing monooxygenase activity",
"flavin mixed function o... | [
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [
"GO:0047076"
] | [] | [
"MetaCyc:1.14.13.8-RXN",
"Reactome:R-HSA-139970 \"FMO3:FAD N-oxidises TMA to TMAO\"",
"Reactome:R-HSA-217255 \"FMO1:FAD N-oxidises TAM\"",
"Reactome:R-HSA-5602966 \"Defective FMO3 does not N-oxidise TMA\"",
"RHEA:24468"
] | [
"GO:0016709"
] | [] | [] | [] | [
"GO:0016709"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:1.14.13.8",
"skos:exactMatch RHEA:24468",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27695\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28070\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004500 | 4,500 | dopamine beta-monooxygenase activity | molecular_function | Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O. | [
"EC:1.14.17.1",
"RHEA:19117"
] | null | [
"(3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity",
"3,4-dihydroxyphenethylamine beta-oxidase activity",
"3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)",
"4-(2-aminoethyl)pyrocatechol beta-oxidase activity",
"dopa beta-hydroxylase activity",
"dopamine b-hydroxyl... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.14.17.1",
"KEGG_REACTION:R02535",
"MetaCyc:DOPAMINE-BETA-MONOOXYGENASE-RXN",
"Reactome:R-HSA-209891 \"Dopamine is oxidised to noradrenaline\"",
"RHEA:19117"
] | [
"GO:0016715"
] | [] | [] | [] | [
"GO:0016715"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.14.17.1",
"skos:exactMatch RHEA:19117",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004502 | 4,502 | kynurenine 3-monooxygenase activity | molecular_function | Catalysis of the reaction: L-kynurenine + H+ + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP+. | [
"EC:1.14.13.9",
"RHEA:20545"
] | null | [
"kynurenine 3-hydroxylase activity",
"kynurenine hydroxylase activity",
"L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)",
"L-kynurenine-3-hydroxylase activity"
] | [
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.14.13.9",
"KEGG_REACTION:R01960",
"MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN",
"Reactome:R-HSA-71200 \"kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O\"",
"RHEA:20545"
] | [
"GO:0016709"
] | [] | [] | [] | [
"GO:0016709"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.14.13.9",
"skos:exactMatch RHEA:20545",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004503 | 4,503 | tyrosinase activity | molecular_function | Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates. | [
"PMID:4965136",
"RHEA:18117"
] | In mammals, L-DOPA can act as a cofactor for the catalyzed reaction; therefore in some resources L-DOPA is shown on both sides of the reaction. GO:0004503 describes the monooxygenation of the monophenol, L-tyrosine. For oxidation of diphenols (including L-DOPA and dopamine), consider instead the term 'catechol oxidase ... | [
"catecholase",
"chlorogenic acid oxidase activity",
"chlorogenic oxidase activity",
"cresolase activity",
"dopa oxidase",
"L-tyrosine monooxygenase activity",
"monophenol monooxidase activity",
"monophenol monooxygenase activity",
"monophenol oxidase activity",
"monophenol oxygenase",
"monopheno... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"EXACT",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"BROAD",
"RELATED"
] | [] | [] | [
"EC:1.14.18.1",
"MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN",
"RHEA:18117"
] | [
"GO:0016716"
] | [] | [] | [] | [
"GO:0016716"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.14.18.1",
"skos:narrowMatch RHEA:18117",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21024\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004505 | 4,505 | phenylalanine 4-monooxygenase activity | molecular_function | Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin. | [
"PMID:4004813",
"RHEA:20273"
] | null | [
"L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)",
"PAH activity",
"phenylalaninase activity",
"phenylalanine 4-hydroxylase activity",
"phenylalanine hydroxylase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:1.14.16.1",
"MetaCyc:RXN66-569",
"Reactome:R-HSA-5649483 \"Defective PAH does not hydroxylate L-Phe to L-Tyr\"",
"Reactome:R-HSA-71118 \"PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr\"",
"RHEA:20273"
] | [
"GO:0016714"
] | [
"part_of GO:0006571"
] | [
"part_of"
] | [
"GO:0006571"
] | [
"GO:0006571",
"GO:0016714"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.14.16.1",
"skos:exactMatch RHEA:20273",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20583\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004506 | 4,506 | squalene monooxygenase activity | molecular_function | Catalysis of the reaction: H+ + NADPH + O2 + squalene = (S)-2,3-epoxysqualene + H2O + NADP+. | [
"RHEA:25282"
] | null | [
"squalene 2,3-oxidocyclase activity",
"squalene epoxidase activity",
"squalene hydroxylase activity",
"squalene oxydocyclase activity",
"squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity",
"squalene-2,3-epoxidase activity",
"squalene-2,3-epoxide cyclase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.14.14.17",
"KEGG_REACTION:R02874",
"MetaCyc:SQUALENE-MONOOXYGENASE-RXN",
"Reactome:R-HSA-191299 \"Squalene is oxidized to its epoxide\"",
"RHEA:25282"
] | [
"GO:0016709"
] | [] | [] | [] | [
"GO:0016709"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.14.14.17",
"skos:exactMatch RHEA:25282",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004507 | 4,507 | steroid 11-beta-monooxygenase activity | molecular_function | Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O. | [
"EC:1.14.15.4"
] | null | [
"cytochrome P450 CYP11B1",
"cytochrome P450 CYP11B2",
"cytochrome p450 XIB1 activity",
"oxygenase, steroid 11beta -mono-",
"steroid 11-beta-hydroxylase activity",
"steroid 11-beta/18-hydroxylase activity",
"steroid 11beta-hydroxylase activity",
"steroid 11beta-monooxygenase activity",
"steroid 11bet... | [
"NARROW",
"NARROW",
"NARROW",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.14.15.4",
"MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN",
"Reactome:R-HSA-193997 \"CYP11B1 oxidises 11DCORT\"",
"Reactome:R-HSA-194017 \"CYP11B2 oxidises 11DCORST to CORST\"",
"Reactome:R-HSA-5580292 \"Defective CYP11B1 does not oxidise 11DCORT\"",
"Reactome:R-HSA-5600598 \"Defective CYP11B2 does not o... | [
"GO:0008395",
"GO:0016713"
] | [] | [] | [] | [
"GO:0008395",
"GO:0016713"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.14.15.4",
"skos:exactMatch RHEA:15629",
"skos:narrowMatch RHEA:46100",
"skos:narrowMatch RHEA:46104",
"skos:narrowMatch RHEA:84067",
"skos:narrowMatch RHEA:84071",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004509 | 4,509 | steroid 21-monooxygenase activity | molecular_function | Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O. | [
"RHEA:65612"
] | null | [
"21-hydroxylase activity",
"cytochrome P450 CYP21A1",
"cytochrome p450 XXIA1 activity",
"steroid 21-hydroxylase activity",
"steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)"
] | [
"RELATED",
"NARROW",
"NARROW",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:1.14.14.16",
"MetaCyc:STEROID-21-MONOOXYGENASE-RXN",
"Reactome:R-HSA-5601976 \"Defective CYP21A2 does not 21-hydroxylate PROG\"",
"RHEA:65612"
] | [
"GO:0008395",
"GO:0016712"
] | [] | [] | [] | [
"GO:0008395",
"GO:0016712"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.14.14.16",
"skos:exactMatch RHEA:65612",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29041\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004510 | 4,510 | tryptophan 5-monooxygenase activity | molecular_function | Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O. | [
"EC:1.14.16.4"
] | null | [
"indoleacetic acid-5-hydroxylase activity",
"L-tryptophan hydroxylase activity",
"L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)",
"tryptophan 5-hydroxylase activity",
"tryptophan hydroxylase activity"
] | [
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.14.16.4",
"MetaCyc:TRYPTOPHAN-5-MONOOXYGENASE-RXN",
"Reactome:R-HSA-209828 \"Tryptophan is hydroxylated\"",
"RHEA:16709"
] | [
"GO:0016714"
] | [] | [] | [] | [
"GO:0016714"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.14.16.4",
"skos:exactMatch RHEA:16709",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004511 | 4,511 | tyrosine 3-monooxygenase activity | molecular_function | Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. | [
"EC:1.14.16.2"
] | null | [
"L-tyrosine hydroxylase activity",
"L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)",
"tyrosine 3-hydroxylase activity",
"tyrosine hydroxylase activity"
] | [
"RELATED",
"RELATED",
"EXACT",
"EXACT"
] | [] | [] | [
"EC:1.14.16.2",
"MetaCyc:TYROSINE-3-MONOOXYGENASE-RXN",
"Reactome:R-HSA-209823 \"Tyrosine is hydroxylated to dopa\"",
"RHEA:18201"
] | [
"GO:0016714"
] | [] | [] | [] | [
"GO:0016714"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.14.16.2",
"skos:exactMatch RHEA:18201",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004512 | 4,512 | inositol-3-phosphate synthase activity | molecular_function | Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the ... | [
"EC:5.5.1.4",
"RHEA:10716"
] | null | [
"1L-myo-inositol-1-phosphate lyase (isomerizing)",
"D-glucose 6-phosphate cycloaldolase activity",
"glucocycloaldolase activity",
"glucose 6-phosphate cyclase activity",
"glucose-6-phosphate inositol monophosphate cycloaldolase activity",
"inositol 1-phosphate synthatase activity",
"inositol 1-phosphate... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:5.5.1.4",
"KEGG_REACTION:R07324",
"MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN",
"Reactome:R-HSA-1855178 \"Glc6P is isomerised to I3P by ISYNA1 in the cytosol\"",
"RHEA:10716"
] | [
"GO:0016872"
] | [] | [] | [] | [
"GO:0016872"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.5.1.4",
"skos:exactMatch RHEA:10716",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004514 | 4,514 | nicotinate-nucleotide diphosphorylase (carboxylating) activity | molecular_function | Catalysis of the reaction: CO2 + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate. | [
"EC:2.4.2.19",
"RHEA:12733"
] | null | [
"NAD pyrophosphorylase activity",
"nicotinate mononucleotide pyrophosphorylase (carboxylating)",
"nicotinate-nucleotide pyrophosphorylase (carboxylating) activity",
"nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)",
"QAPRTase activity",
"quinolinate phosphoribosyltrans... | [
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.2.19",
"KEGG_REACTION:R03348",
"MetaCyc:QUINOPRIBOTRANS-RXN",
"Reactome:R-HSA-197268 \"QPRT transfers PRIB to QUIN to form NAMN\"",
"RHEA:12733"
] | [
"GO:0016763"
] | [] | [] | [] | [
"GO:0016763"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.2.19",
"skos:exactMatch RHEA:12733",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004515 | 4,515 | nicotinate-nucleotide adenylyltransferase activity | molecular_function | Catalysis of the reaction: nicotinate beta-D-ribonucleotide + ATP + H+ = deamido-NAD+ + diphosphate. | [
"RHEA:22860"
] | null | [
"ATP:nicotinate-nucleotide adenylyltransferase activity",
"ATP:nicotinate-ribonucleotide adenylyltransferase activity",
"deamido-NAD(+) diphosphorylase activity",
"deamido-NAD(+) pyrophosphorylase activity",
"deamido-NAD+ pyrophosphorylase activity",
"deamidonicotinamide adenine dinucleotide pyrophosphory... | [
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW"
] | [] | [] | [
"EC:2.7.7.18",
"MetaCyc:NICONUCADENYLYLTRAN-RXN",
"Reactome:R-HSA-197235 \"NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD\"",
"Reactome:R-HSA-200474 \"NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD\"",
"Reactome:R-HSA-200512 \"NMNAT1 transfers an adenylyl group from ATP... | [
"GO:0070566"
] | [] | [] | [] | [
"GO:0070566"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.7.18",
"skos:exactMatch MetaCyc:NICONUCADENYLYLTRAN-RXN",
"skos:exactMatch RHEA:22860",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29467\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004517 | 4,517 | nitric-oxide synthase activity | molecular_function | Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. | [
"EC:1.14.13.39",
"RHEA:19897"
] | null | [
"endothelium-derived relaxation factor-forming enzyme activity",
"endothelium-derived relaxing factor synthase activity",
"L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity",
"NADPH-diaphorase activity",
"nitric oxide synthase activity",
"nitric oxide synthetase activity",
"nitric-o... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.14.13.39",
"MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN",
"Reactome:R-HSA-202127 \"eNOS synthesizes NO\"",
"Reactome:R-HSA-418436 \"Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)\"",
"RHEA:19897"
] | [
"GO:0016709"
] | [] | [] | [] | [
"GO:0016709"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.14.13.39",
"skos:exactMatch RHEA:19897",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004519 | 4,519 | endonuclease activity | molecular_function | Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. | [
"GOC:mah",
"ISBN:0198547684"
] | null | [] | [] | [] | [] | [
"Reactome:R-HSA-5358512 \"MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more\"",
"Reactome:R-HSA-5358518 \"MLH1:PMS2 makes single strand incision near 1-2 base mismatch\"",
"Reactome:R-HSA-5690990 \"5'- incision of DNA by ERCC1:ERCC4 in GG-NER\"",
"Reactome:R-HSA-5693533 \... | [
"GO:0004518"
] | [] | [] | [] | [
"GO:0004518"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24408\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004522 | 4,522 | ribonuclease A activity | molecular_function | Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. | [
"EC:4.6.1.18"
] | null | [
"alkaline ribonuclease activity",
"ceratitis capitata alkaline ribonuclease activity",
"endoribonuclease I",
"gene S glycoproteins",
"gene S locus-specific glycoproteins",
"pancreatic ribonuclease activity",
"pancreatic RNase activity",
"ribonuclease I activity",
"ribonucleate 3'-pyrimidino-oligonuc... | [
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"EXACT",
"EXACT",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.6.1.18",
"MetaCyc:RXN-19932",
"MetaCyc:RXN-19933",
"Wikipedia:Ribonuclease_A"
] | [
"GO:0004521",
"GO:0016849"
] | [] | [] | [] | [
"GO:0004521",
"GO:0016849"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.6.1.18",
"skos:narrowMatch MetaCyc:RXN-19932",
"skos:narrowMatch MetaCyc:RXN-19933",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24408\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28183\" xsd:anyURI",
"term_tracker... | null | null | false | true | 6 |
GO:0004523 | 4,523 | RNA-DNA hybrid ribonuclease activity | molecular_function | Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. | [
"EC:3.1.26.4"
] | Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species. | [
"calf thymus ribonuclease H activity",
"endoribonuclease H",
"endoribonuclease H (calf thymus)",
"endoribonuclease0 H activity",
"hybrid nuclease activity",
"hybrid ribonuclease activity",
"hybridase (ribonuclease H)",
"hybridase activity",
"ribonuclease H activity",
"ribonuclease H1 activity",
... | [
"EXACT",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"NARROW",
"NARROW",
"NARROW",
"RELATED",
"EXACT",
"NARROW",
"NARROW",
"NARROW"
] | [
"GO:0004524"
] | [] | [
"EC:3.1.26.4",
"MetaCyc:3.1.26.4-RXN",
"Reactome:R-HSA-164519 \"RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex\"",
"Reactome:R-HSA-164528 \"RNase H-mediated cleavage of the template strand\"",
"Reactome:R-HSA-173769 \"RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers\"",
... | [
"GO:0016891"
] | [] | [] | [] | [
"GO:0016891"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.26.4",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004526 | 4,526 | ribonuclease P activity | molecular_function | Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. | [
"EC:3.1.26.5"
] | null | [
"RNase P",
"tRNA 5' leader endonuclease activity"
] | [
"EXACT",
"EXACT"
] | [] | [] | [
"EC:3.1.26.5",
"MetaCyc:3.1.26.5-RXN",
"Reactome:R-HSA-5696810 \"RNase P cleaves the 5' end of pre-tRNA\"",
"Wikipedia:RNase_P"
] | [
"GO:0004549",
"GO:0016891"
] | [] | [] | [] | [
"GO:0004549",
"GO:0016891"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.26.5",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004527 | 4,527 | exonuclease activity | molecular_function | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. | [
"GOC:mah",
"ISBN:0198547684"
] | null | [
"exonuclease IX activity"
] | [
"NARROW"
] | [
"GO:0008857"
] | [] | [] | [
"GO:0004518",
"GO:0016788"
] | [] | [] | [] | [
"GO:0004518",
"GO:0016788"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 3 |
GO:0004528 | 4,528 | phosphodiesterase I activity | molecular_function | Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. | [
"EC:3.1.4.1"
] | null | [
"5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity",
"5'-exonuclease activity",
"5'-NPDase activity",
"5'-nucleotide phosphodiesterase activity",
"5'-PDase activity",
"5'-PDE activity",
"5'-phosphodiesterase activity",
"5'NPDE activity",
"alkaline phosphodiesterase activity",
"... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD"
] | [] | [] | [
"EC:3.1.4.1",
"MetaCyc:3.1.4.1-RXN"
] | [
"GO:0004527",
"GO:0008081"
] | [] | [] | [] | [
"GO:0004527",
"GO:0008081"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.4.1",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004529 | 4,529 | DNA exonuclease activity | molecular_function | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. | [
"GOC:mah",
"ISBN:0198547684"
] | null | [] | [] | [] | [] | [] | [
"GO:0004527",
"GO:0004536"
] | [] | [] | [] | [
"GO:0004527",
"GO:0004536"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 7 |
GO:0004530 | 4,530 | deoxyribonuclease I activity | molecular_function | Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products. | [
"EC:3.1.21.1"
] | null | [
"alkaline deoxyribonuclease activity",
"alkaline DNase activity",
"deoxyribonuclease (pancreatic)",
"deoxyribonuclease A",
"deoxyribonucleic phosphatase activity",
"DNA depolymerase activity",
"DNA endonuclease activity",
"DNA nuclease activity",
"DNAase activity",
"DNase activity",
"DNase I",
... | [
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"RELATED"
] | [] | [] | [
"EC:3.1.21.1",
"MetaCyc:3.1.21.1-RXN"
] | [
"GO:0016888"
] | [] | [] | [] | [
"GO:0016888"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.21.1",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004531 | 4,531 | deoxyribonuclease II activity | molecular_function | Catalysis of the endonucleolytic cleavage of DNA to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products. | [
"EC:3.1.22.1"
] | null | [
"acid deoxyribonuclease activity",
"acid DNase activity",
"deoxyribonucleate 3'-nucleotidohydrolase activity",
"DNase II activity",
"lysosomal DNase II activity",
"pancreatic DNase II"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"RELATED"
] | [] | [] | [
"EC:3.1.22.1",
"MetaCyc:3.1.22.1-RXN"
] | [
"GO:0016889"
] | [] | [] | [] | [
"GO:0016889"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.22.1",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30976\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004532 | 4,532 | RNA exonuclease activity | molecular_function | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. | [
"GOC:mah",
"ISBN:0198547684"
] | null | [
"exoribonuclease activity"
] | [
"EXACT"
] | [] | [] | [
"Reactome:R-HSA-429961 \"DCPS scavenges the 7-methylguanosine cap of mRNA\""
] | [
"GO:0004527",
"GO:0004540"
] | [] | [] | [] | [
"GO:0004527",
"GO:0004540"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24408\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004533 | 4,533 | exoribonuclease H activity | molecular_function | Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions. | [
"EC:3.1.13.2"
] | null | [
"retroviral reverse transcriptase RNaseH"
] | [
"RELATED"
] | [] | [] | [
"EC:3.1.13.2",
"MetaCyc:3.1.13.2-RXN"
] | [
"GO:0016896"
] | [] | [] | [] | [
"GO:0016896"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.13.2",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004534 | 4,534 | 5'-3' RNA exonuclease activity | molecular_function | Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule. | [
"GOC:mah",
"ISBN:0198547684"
] | null | [
"5'-3' exoribonuclease activity"
] | [
"EXACT"
] | [] | [] | [
"Reactome:R-HSA-429845 \"5' to 3' exoribonuclease hydrolyzes decapped mRNA\"",
"Reactome:R-HSA-6791227 \"47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA\"",
"Reactome:R-HSA-9915442 \"EXOG cleaves RNA dinucleotide from nascent mitochondrial DNA\"",
... | [
"GO:0008409",
"GO:0016896"
] | [] | [] | [] | [
"GO:0008409",
"GO:0016896"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28062\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004535 | 4,535 | poly(A)-specific ribonuclease activity | molecular_function | Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. | [
"EC:3.1.13.4",
"ISBN:0198547684"
] | null | [
"2',3'-exoribonuclease activity",
"3'-exoribonuclease activity",
"poly(A)-specific RNase activity"
] | [
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:3.1.13.4",
"MetaCyc:3.1.13.4-RXN",
"Reactome:R-HSA-429955 \"CCR4-NOT complex deadenylates mRNA\"",
"Reactome:R-HSA-429992 \"PARN deadenylates mRNA\"",
"Reactome:R-HSA-430021 \"PAN2-PAN3 complex partially deadenylates mRNA\"",
"Reactome:R-HSA-9009950 \"PDE12 cleaves 2'-5' oligoadenylates\"",
"Reactom... | [
"GO:0000175"
] | [] | [] | [] | [
"GO:0000175"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.13.4",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004536 | 4,536 | DNA nuclease activity | molecular_function | Catalysis of the cleavage of ester linkages within deoxyribonucleic acid. | [
"GOC:mah",
"ISBN:0198547684"
] | null | [
"caspase-activated deoxyribonuclease activity",
"deoxyribonuclease activity"
] | [
"NARROW",
"EXACT"
] | [
"GO:0004537"
] | [] | [
"Reactome:R-HSA-211247 \"Cleavage of DNA by DFF40\"",
"Reactome:R-HSA-5685994 \"Long-range resection of DNA DSBs by EXO1 or DNA2\"",
"Reactome:R-HSA-6785986 \"DNA nucleases unhook the interstrand crosslink (ICL)\""
] | [
"GO:0004518",
"GO:0140097"
] | [] | [] | [] | [
"GO:0004518",
"GO:0140097"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24408\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004540 | 4,540 | RNA nuclease activity | molecular_function | Catalysis of the cleavage of phosphodiester bonds in chains of RNA. | [
"GOC:mah",
"ISBN:0198547684"
] | null | [
"ribonuclease activity"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0004518",
"GO:0140098"
] | [] | [] | [] | [
"GO:0004518",
"GO:0140098"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24408\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004550 | 4,550 | nucleoside diphosphate kinase activity | molecular_function | Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. | [
"EC:2.7.4.6"
] | null | [
"ATP:nucleoside-diphosphate phosphotransferase activity",
"NDK activity",
"nucleoside 5'-diphosphate kinase activity",
"nucleoside 5'-diphosphate phosphotransferase activity",
"nucleoside diphosphate (UDP) kinase activity",
"nucleoside diphosphokinase activity",
"nucleoside-diphosphate kinase activity",... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.4.6",
"MetaCyc:NUCLEOSIDE-DIP-KIN-RXN",
"Reactome:R-HSA-2162096 \"carbovir diphosphate + ATP => carbovir triphosphate + ADP\"",
"Reactome:R-HSA-482619 \"(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)\"",
"Reactome:R-HSA-482621 \"(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)\"",
"Reactome:R-HSA-482804 \"(d)ND... | [
"GO:0016776",
"GO:0019205"
] | [] | [] | [] | [
"GO:0016776",
"GO:0019205"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.4.6",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004551 | 4,551 | dinucleotide phosphatase activity | molecular_function | Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides. | [
"PMID:2848456",
"PMID:4405504"
] | null | [
"dinucleotide nucleotidohydrolase activity",
"nucleotide diphosphatase activity",
"nucleotide pyrophosphatase activity"
] | [
"RELATED",
"BROAD",
"EXACT"
] | [] | [] | [
"Reactome:R-HSA-196955 \"2xENPP1 hydrolyzes FAD to FMN\""
] | [
"GO:0016462"
] | [] | [] | [] | [
"GO:0016462"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23401\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28183\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004552 | 4,552 | octanol dehydrogenase (NAD+) activity | molecular_function | Catalysis of the reaction: 1-octanol + NAD+ = 1-octanal + H+ + NADH. | [
"EC:1.1.1.73",
"RHEA:24620"
] | null | [
"1-octanol dehydrogenase activity",
"octanol dehydrogenase activity",
"octanol:NAD+ oxidoreductase activity"
] | [
"RELATED",
"BROAD",
"RELATED"
] | [] | [] | [
"EC:1.1.1.73",
"KEGG_REACTION:R02878",
"MetaCyc:OCTANOL-DEHYDROGENASE-RXN",
"RHEA:24620"
] | [
"GO:0004022"
] | [] | [] | [] | [
"GO:0004022"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.73",
"skos:exactMatch RHEA:24620",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27136\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004553 | 4,553 | hydrolase activity, hydrolyzing O-glycosyl compounds | molecular_function | Catalysis of the hydrolysis of any O-glycosyl bond. | [
"GOC:mah"
] | null | [
"O-glucosyl hydrolase activity"
] | [
"EXACT"
] | [
"GO:0016800"
] | [] | [
"EC:3.2.1.-",
"Reactome:R-HSA-5694563 \"ABHD10 hydrolyses MPAG\"",
"Reactome:R-HSA-6786652 \"CHIT1 hydrolyses CHIT to 3xADGP\"",
"Reactome:R-HSA-9661820 \"Bacterial GUSB hydrolyses BDG to BIL\""
] | [
"GO:0016798"
] | [] | [] | [] | [
"GO:0016798"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.-",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004555 | 4,555 | alpha,alpha-trehalase activity | molecular_function | Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose. | [
"PMID:19897915",
"RHEA:32675"
] | null | [
"alpha,alpha-trehalose glucohydrolase activity"
] | [
"RELATED"
] | [] | [] | [
"EC:3.2.1.28",
"MetaCyc:TREHALA-RXN",
"Reactome:R-HSA-188985 \"trehalose + H2O => 2 D-glucose\"",
"RHEA:32675"
] | [
"GO:0015927"
] | [] | [] | [] | [
"GO:0015927"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.28",
"skos:exactMatch RHEA:32675",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004556 | 4,556 | alpha-amylase activity | molecular_function | Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units. | [
"PMID:12527308"
] | null | [
"1,4-alpha-D-glucan glucanohydrolase activity",
"alpha amylase activity",
"alpha-amylase activity (releasing maltohexaose)",
"endoamylase activity",
"glycogenase activity",
"taka-amylase A"
] | [
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"BROAD",
"RELATED"
] | [
"GO:0103025"
] | [] | [
"EC:3.2.1.1",
"MetaCyc:ALPHA-AMYL-RXN",
"MetaCyc:RXN-1823",
"MetaCyc:RXN-1825",
"MetaCyc:RXN0-5181",
"Reactome:R-HSA-188979 \"Digestion of linear starch (amylose) by extracellular amylase\"",
"Reactome:R-HSA-191114 \"Digestion of branched starch (amylopectin) by extracellular amylase\""
] | [
"GO:0016160"
] | [] | [] | [] | [
"GO:0016160"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.1",
"skos:exactMatch MetaCyc:ALPHA-AMYL-RXN",
"skos:narrowMatch MetaCyc:RXN-1823",
"skos:narrowMatch MetaCyc:RXN-1825",
"skos:narrowMatch MetaCyc:RXN0-5181",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22621\" xsd:anyURI",
"term_tracker_item \"https:... | null | null | false | true | 6 |
GO:0004557 | 4,557 | alpha-galactosidase activity | molecular_function | Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids. | [
"EC:3.2.1.22"
] | null | [
"alpha-D-galactosidase activity",
"melibiase activity"
] | [
"RELATED",
"EXACT"
] | [] | [] | [
"EC:3.2.1.22",
"MetaCyc:ALPHAGALACTOSID-RXN",
"Reactome:R-HSA-1605736 \"GLA hydrolyzes PSAP(195-273):Gb3Cer:PE\"",
"Reactome:R-HSA-9841189 \"GLA hydrolyzes PSAP(195-273):Gal2Cer:PE\"",
"RHEA:21112",
"RHEA:28663"
] | [
"GO:0015925"
] | [] | [] | [] | [
"GO:0015925"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.22",
"skos:narrowMatch RHEA:21112",
"skos:narrowMatch RHEA:28663",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24117\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25227\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004558 | 4,558 | alpha-1,4-glucosidase activity | molecular_function | Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. | [
"EC:3.2.1.20"
] | null | [
"acid maltase activity",
"alpha-D-glucosidase activity",
"alpha-D-glucoside glucohydrolase activity",
"alpha-glucopyranosidase activity",
"alpha-glucoside hydrolase activity",
"glucoinvertase activity",
"glucosidoinvertase activity",
"glucosidosucrase activity",
"lysosomal alpha-glucosidase activity... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED"
] | [
"GO:0004562",
"GO:0016982"
] | [] | [
"EC:3.2.1.20",
"MetaCyc:MALTODEXGLUCOSID-RXN",
"Reactome:R-HSA-189053 \"Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose\"",
"Reactome:R-HSA-189102 \"maltose + H2O => 2 D-glucose (maltase-glucoamylase)\"",
"Reactome:R-HSA-191101 \"maltotriose + H2O =>... | [
"GO:0090599"
] | [] | [] | [] | [
"GO:0090599"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.20",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24984\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004559 | 4,559 | alpha-mannosidase activity | molecular_function | Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. | [
"EC:3.2.1.24"
] | null | [
"1,2-alpha-D-mannosidase activity",
"1,2-alpha-mannosidase",
"alpha-D-mannopyranosidase activity",
"alpha-D-mannosidase activity",
"alpha-D-mannoside mannohydrolase activity",
"exo-alpha-mannosidase activity",
"p-nitrophenyl-alpha-mannosidase activity"
] | [
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW"
] | [] | [] | [
"EC:3.2.1.24",
"MetaCyc:3.2.1.24-RXN",
"Reactome:R-HSA-6799545 \"MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5\"",
"Reactome:R-HSA-8853686 \"MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3\"",
"Reactome:R-HSA-9694656 \"Spike trimer glycoside chains are extended\""
] | [
"GO:0015923"
] | [] | [] | [] | [
"GO:0015923"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.24",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004560 | 4,560 | alpha-L-fucosidase activity | molecular_function | Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose. | [
"EC:3.2.1.51"
] | null | [
"alpha-fucosidase activity",
"alpha-L-fucoside fucohydrolase activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.2.1.51",
"MetaCyc:ALPHA-L-FUCOSIDASE-RXN",
"Reactome:R-HSA-5693807 \"FUCA1 hydrolyses NGP:1,6-GlcNAc\"",
"RHEA:12288"
] | [
"GO:0015928"
] | [] | [] | [] | [
"GO:0015928"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.51",
"skos:exactMatch RHEA:12288",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004561 | 4,561 | alpha-N-acetylglucosaminidase activity | molecular_function | Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. | [
"EC:3.2.1.50"
] | null | [
"alpha-acetylglucosaminidase activity",
"alpha-D-2-acetamido-2-deoxyglucosidase activity",
"alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity",
"N-acetyl-alpha-D-glucosaminidase activity",
"N-acetyl-alpha-glucosaminidase activity",
"NAG activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.2.1.50",
"MetaCyc:3.2.1.50-RXN",
"Reactome:R-HSA-1678742 \"NAGLU hydrolyses Heparan sulfate chain(4)\"",
"Reactome:R-HSA-2090038 \"NAGLU hydrolyses heparan chain(2)\"",
"Reactome:R-HSA-2263496 \"Defective NAGLU does not hydrolyse Heparan sulfate chain(4)\"",
"Reactome:R-HSA-9036052 \"Defective NAGLU... | [
"GO:0015929"
] | [] | [] | [] | [
"GO:0015929"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.50",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004563 | 4,563 | beta-N-acetylhexosaminidase activity | molecular_function | Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. | [
"EC:3.2.1.52"
] | null | [
"beta-acetylaminodeoxyhexosidase activity",
"beta-acetylhexosaminidinase activity",
"beta-D-hexosaminidase activity",
"beta-D-N-acetylhexosaminidase activity",
"beta-hexosaminidase activity",
"beta-N-acetyl-D-hexosaminidase activity",
"beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity",
... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.2.1.52",
"MetaCyc:3.2.1.52-RXN",
"Reactome:R-HSA-1605595 \"bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3\"",
"Reactome:R-HSA-1605632 \"bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE\"",
"Reactome:R-HSA-1638053 \"HEXA cleaves the terminal GlcNAc from keratan sulfate\"",
"Reactome:R-HSA-2105001 \"HEXA cleaves ... | [
"GO:0015929"
] | [] | [] | [] | [
"GO:0015929"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.52",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28183\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004565 | 4,565 | beta-galactosidase activity | molecular_function | Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. | [
"EC:3.2.1.23"
] | null | [
"beta-D-galactanase activity",
"beta-D-galactoside galactohydrolase activity",
"beta-D-lactosidase activity",
"beta-lactosidase activity",
"exo-(1->4)-beta-D-galactanase activity",
"hydrolact"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.2.1.23",
"MetaCyc:3.2.1.23-RXN",
"Reactome:R-HSA-1605624 \"Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2\"",
"Reactome:R-HSA-1606312 \"GLB1 hydrolyzes SapB/C:LacCer\"",
"Reactome:R-HSA-1630306 \"GLB1 hydrolyses a glycosaminoglycan\"",
"Reactome:R-HSA-1793217 \"Unknown endo--galactosid... | [
"GO:0015925"
] | [] | [] | [] | [
"GO:0015925"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.23",
"skos:exactMatch MetaCyc:3.2.1.23-RXN",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28526\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31587\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004566 | 4,566 | beta-glucuronidase activity | molecular_function | Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate. | [
"EC:3.2.1.31"
] | null | [
"beta-D-glucuronoside glucuronosohydrolase activity",
"beta-glucuronide glucuronohydrolase activity",
"exo-beta-D-glucuronidase activity",
"glucuronidase activity",
"ketodase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.2.1.31",
"MetaCyc:BETA-GLUCURONID-RXN",
"Reactome:R-HSA-1678854 \"GUSB tetramer hydrolyses CS/HS precursor\"",
"Reactome:R-HSA-2162226 \"GUSB tetramer hydrolyzes GlcA-1,3-GlcNAc\"",
"Reactome:R-HSA-2162227 \"GUSB tetramer hydrolyses (HA)2\"",
"Reactome:R-HSA-2318373 \"Defective GUSB does not hydroly... | [
"GO:0046574"
] | [] | [] | [] | [
"GO:0046574"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.31",
"skos:exactMatch RHEA:17633",
"skos:narrowMatch RHEA:28326",
"skos:narrowMatch RHEA:30475",
"skos:narrowMatch RHEA:76111",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-o... | null | null | false | true | 3 |
GO:0004567 | 4,567 | beta-mannosidase activity | molecular_function | Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. | [
"EC:3.2.1.25"
] | null | [
"beta-D-mannosidase activity",
"beta-D-mannoside mannohydrolase activity",
"beta-mannoside mannohydrolase activity",
"exo-beta-D-mannanase activity",
"mannanase activity",
"mannase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.2.1.25",
"MetaCyc:3.2.1.25-RXN",
"Reactome:R-HSA-8853710 \"MANBA hydrolyses GlcNAc:Man\""
] | [
"GO:0015923"
] | [] | [] | [] | [
"GO:0015923"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.25",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004568 | 4,568 | chitinase activity | molecular_function | Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. | [
"GOC:bf",
"GOC:kah",
"GOC:pde",
"PMID:11468293"
] | null | [] | [] | [] | [] | [
"Reactome:R-HSA-6786421 \"CHIA hydrolyses chitin\""
] | [
"GO:0004553"
] | [] | [] | [] | [
"GO:0004553"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28722\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004571 | 4,571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | molecular_function | Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide. | [
"GOC:bf",
"PMID:25092655"
] | null | [
"1,2-alpha-mannosidase",
"1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity",
"exo-alpha-1,2-mannanase activity",
"glycoprotein processing mannosidase I",
"Man9-mannosidase activity",
"ManI activity",
"mannose-9 processing alpha-mannosidase activity",
"mannosidase 1A activity",
"man... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"RELATED"
] | [] | [] | [
"EC:3.2.1.113",
"KEGG_REACTION:R12479",
"MetaCyc:RXN-18910",
"MetaCyc:RXN-18911",
"Reactome:R-HSA-4793949 \"Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch)\"",
"Reactome:R-HSA-6782685 \"EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5\"",
"Reactome:R-HSA-901024 \"MAN1B1 hydrolys... | [
"GO:0015924"
] | [] | [] | [] | [
"GO:0015924"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.113",
"skos:narrowMatch MetaCyc:RXN-18910",
"skos:narrowMatch MetaCyc:RXN-18911",
"skos:narrowMatch RHEA:56008",
"skos:narrowMatch RHEA:56028",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28133\" xsd:anyURI",
"term_tracker_item \"https://github.com/g... | null | null | false | true | 8 |
GO:0004572 | 4,572 | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity | molecular_function | Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3). | [
"EC:3.2.1.114"
] | null | [
"1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity",
"alpha-(1,3/6)-mannosidase activity",
"alpha-D-mannosidase II",
"alpha-mannosidase II",
"exo-1,3-1,6-alpha-mannosidase activity",
"GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity",
"Golgi alpha-mannosidase II",
... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [
"EC:3.2.1.114",
"MetaCyc:3.2.1.114-RXN",
"Reactome:R-HSA-975814 \"Trimming of mannoses on the alpha1,6 arm by MAN2A1\"",
"RHEA:56052"
] | [
"GO:0015924"
] | [] | [] | [] | [
"GO:0015924"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.114",
"skos:exactMatch RHEA:56052",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004573 | 4,573 | Glc3Man9GlcNAc2 oligosaccharide glucosidase activity | molecular_function | Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2). | [
"EC:3.2.1.106"
] | null | [
"mannosyl-oligosaccharide glucohydrolase activity",
"mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity",
"mannosyl-oligosaccharide glucosidase activity",
"processing A-glucosidase I activity",
"trimming glucosidase I"
] | [
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:3.2.1.106",
"MetaCyc:3.2.1.106-RXN",
"Reactome:R-HSA-4793947 \"Defective MOGS does not cleave glucose from an N-glycosylated protein\"",
"Reactome:R-HSA-532678 \"Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase\"",
"Reactome:R-HSA-9694364 \"N-glycan glucose trimming of Spike\"",
... | [
"GO:0090599"
] | [] | [] | [] | [
"GO:0090599"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.106",
"skos:exactMatch RHEA:55988",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24984\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004574 | 4,574 | oligo-1,6-glucosidase activity | molecular_function | Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose. | [
"EC:3.2.1.10"
] | null | [
"alpha-limit dextrinase activity",
"alpha-methylglucosidase activity",
"dextrin 6-glucanohydrolase activity",
"dextrin 6alpha-glucanohydrolase activity",
"exo-oligo-1,6-glucosidase activity",
"isomaltase activity",
"limit dextrinase",
"oligosaccharide alpha-1,6-glucohydrolase activity",
"oligosaccha... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.2.1.10",
"MetaCyc:3.2.1.10-RXN",
"RHEA:68864"
] | [
"GO:0090599"
] | [] | [] | [] | [
"GO:0090599"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.10",
"skos:narrowMatch MetaCyc:3.2.1.10-RXN",
"skos:narrowMatch RHEA:68864",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28199\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004575 | 4,575 | sucrose alpha-glucosidase activity | molecular_function | Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose. | [
"RHEA:33795"
] | null | [
"alpha-D-glucopyranosyl beta-D-fructofuranoside hydrolysis",
"beta-D-fructofuranosyl alpha-D-glucopyranoside hydrolysis",
"intestinal sucrase activity",
"sucrase activity",
"sucrase(invertase)",
"sucrase-isomaltase activity",
"sucrose alpha-D-glucohydrolase activity",
"sucrose alpha-glucohydrolase act... | [
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"BROAD",
"RELATED"
] | [] | [] | [
"EC:3.2.1.48",
"KEGG_REACTION:R00802",
"MetaCyc:3.2.1.48-RXN",
"Reactome:R-HSA-189069 \"sucrose + H2O => glucose + fructose\"",
"Reactome:R-HSA-5659926 \"Defective SI does not hydrolyze Suc\"",
"RHEA:33795"
] | [
"GO:0004564",
"GO:0090599"
] | [] | [] | [] | [
"GO:0004564",
"GO:0090599"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.48",
"skos:exactMatch RHEA:33795",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004576 | 4,576 | oligosaccharyl transferase activity | molecular_function | Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid. | [
"GOC:ai"
] | null | [
"oligosaccharide transferase activity"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0016758"
] | [] | [] | [] | [
"GO:0016758"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 1 |
GO:0004577 | 4,577 | N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity | molecular_function | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol. | [
"EC:2.4.1.141"
] | null | [
"N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity",
"UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity",
"UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity",
"uridine diphosphoacetylglucosamine-dolichylacetylglu... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.1.141",
"MetaCyc:2.4.1.141-RXN",
"Reactome:R-HSA-446207 \"ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP\"",
"Reactome:R-HSA-5633241 \"Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP\"",
"RHEA:23380"
] | [
"GO:0008375"
] | [] | [] | [] | [
"GO:0008375"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.141",
"skos:exactMatch RHEA:23380",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004578 | 4,578 | chitobiosyldiphosphodolichol beta-mannosyltransferase activity | molecular_function | Catalysis of the reaction: an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = a beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H+. | [
"RHEA:13865"
] | null | [
"GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity",
"GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity",
"guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.1.142",
"MetaCyc:2.4.1.142-RXN",
"Reactome:R-HSA-446218 \"Addition of the first mannose to the N-glycan precursor by ALG1\"",
"Reactome:R-HSA-4549382 \"Defective ALG1 does not transfer the first Man to the N-glycan precursor\"",
"RHEA:13865"
] | [
"GO:0019187",
"GO:0120562"
] | [] | [] | [] | [
"GO:0019187",
"GO:0120562"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.142",
"skos:exactMatch RHEA:13865",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30326\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004579 | 4,579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity | molecular_function | Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. | [
"RHEA:22980"
] | null | [
"asparagine N-glycosyltransferase activity",
"dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity",
"dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity",
"dolichyldiphosphooligosaccharide-protein glycosyltransferase activity",
"dolichyldiphospho... | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:2.4.99.18",
"MetaCyc:RXN-16761",
"Reactome:R-HSA-446209 \"Transfer of N-glycan to the protein\"",
"Reactome:R-HSA-9694793 \"Spike protein gets N-glycosylated\"",
"Reactome:R-HSA-9816276 \"CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum\"",
"Reactome:R-HSA-9918962 \"E is N-glycos... | [
"GO:0004576"
] | [] | [] | [] | [
"GO:0004576"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.99.18",
"skos:exactMatch RHEA:22980",
"skos:narrowMatch RHEA:50348",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26808\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004581 | 4,581 | dolichyl-phosphate beta-glucosyltransferase activity | molecular_function | Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate. | [
"EC:2.4.1.117"
] | null | [
"polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity",
"UDP-glucose dolichyl-phosphate glucosyltransferase activity",
"UDP-glucose:dolichol phosphate glucosyltransferase activity",
"UDP-glucose:dolicholphosphoryl glucosyltransferase activity",
"UDP-glucose:dolichyl monophosphate glucosyltransfer... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.1.117",
"MetaCyc:2.4.1.117-RXN",
"Reactome:R-HSA-446214 \"Synthesis of dolichyl-phosphate-glucose\"",
"RHEA:15401"
] | [
"GO:0035251"
] | [] | [] | [] | [
"GO:0035251"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.117",
"skos:exactMatch RHEA:15401",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004582 | 4,582 | dolichyl-phosphate beta-D-mannosyltransferase activity | molecular_function | Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate. | [
"EC:2.4.1.83"
] | null | [
"dolichol phosphate mannose synthase activity",
"dolichol-phosphate mannose synthase activity",
"dolichol-phosphate mannosyltransferase activity",
"dolichol-phosphate-mannose synthase activity",
"dolichyl mannosyl phosphate synthase activity",
"dolichyl phosphate mannosyltransferase activity",
"dolichyl... | [
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.1.83",
"MetaCyc:2.4.1.83-RXN",
"Reactome:R-HSA-162721 \"dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose\"",
"Reactome:R-HSA-4717406 \"Defective DPM1 does not transfer mannose to DOLP to form DOLPman\"",
"Reactome:R-HSA-4719354 \"Defective DPM3 does not transfer mannose to DO... | [
"GO:0000030"
] | [] | [] | [] | [
"GO:0000030"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.83",
"skos:exactMatch RHEA:21184",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004583 | 4,583 | dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity | molecular_function | Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide. | [
"GOC:mah"
] | null | [] | [] | [] | [] | [
"Reactome:R-HSA-446189 \"Addition of a second glucose to the N-glycan precursor by ALG8\"",
"Reactome:R-HSA-446194 \"Addition of a third glucose to the N-glycan precursor by an ALG10 homologue\"",
"Reactome:R-HSA-446202 \"Addition of the first glucose to the N-glycan precursor by ALG6\"",
"Reactome:R-HSA-4724... | [
"GO:0046527"
] | [] | [] | [] | [
"GO:0046527"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28029\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004584 | 4,584 | obsolete dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity | molecular_function | OBSOLETE. Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide. | [
"EC:2.4.1.130"
] | The reason for obsoletion is that this activity has been replaced by 4 activities in EC, EC:2.4.1.258, EC:2.4.1.259, EC:2.4.1.260, and EC:2.4.1.261. | [
"dolichol phosphomannose-oligosaccharide-lipid mannosyltransferase activity",
"dolichyl-phosphate-D-mannose:glycolipid alpha-D-mannosyltransferase activity",
"oligomannosylsynthase activity"
] | [
"RELATED",
"RELATED",
"BROAD"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0052917",
"GO:0052918",
"GO:0052925",
"GO:0052926"
] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/16022\" xsd:anyURI"
] | null | null | true | true | 5 |
GO:0004585 | 4,585 | ornithine carbamoyltransferase activity | molecular_function | Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. | [
"EC:2.1.3.3"
] | null | [
"carbamoyl-phosphate:L-ornithine carbamoyltransferase activity",
"carbamylphosphate-ornithine transcarbamylase activity",
"citrulline phosphorylase activity",
"L-ornithine carbamoyltransferase activity",
"L-ornithine carbamyltransferase activity",
"L-ornithine transcarbamylase activity",
"ornithine carb... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.1.3.3",
"MetaCyc:ORNCARBAMTRANSFER-RXN",
"Reactome:R-HSA-70560 \"carbamoyl phosphate + ornithine => citrulline + orthophosphate\"",
"Reactome:R-HSA-9956527 \"OTC variants don't synthesize L-citrulline\"",
"RHEA:19513"
] | [
"GO:0016743"
] | [
"part_of GO:0006591"
] | [
"part_of"
] | [
"GO:0006591"
] | [
"GO:0006591",
"GO:0016743"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.1.3.3",
"skos:exactMatch RHEA:19513",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004586 | 4,586 | ornithine decarboxylase activity | molecular_function | Catalysis of the reaction: L-ornithine + H+ = CO2 + putrescine. | [
"EC:4.1.1.17",
"RHEA:22964"
] | null | [
"L-ornithine carboxy-lyase (putrescine-forming)",
"L-ornithine carboxy-lyase activity",
"SpeC"
] | [
"RELATED",
"NARROW",
"RELATED"
] | [] | [] | [
"EC:4.1.1.17",
"KEGG_REACTION:R00670",
"MetaCyc:ORNDECARBOX-RXN",
"Reactome:R-HSA-70692 \"ornithine => putrescine + CO2\"",
"RHEA:22964"
] | [
"GO:0016831"
] | [] | [] | [] | [
"GO:0016831"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.1.17",
"skos:exactMatch RHEA:22964",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004587 | 4,587 | L-ornithine transaminase activity | molecular_function | Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid. | [
"RHEA:13877"
] | null | [
"GabT",
"L-ornithine 5-aminotransferase activity",
"L-ornithine aminotransferase activity",
"L-ornithine:2-oxo-acid aminotransferase activity",
"L-ornithine:alpha-ketoglutarate delta-aminotransferase activity",
"OAT",
"ornithine 5-aminotransferase activity",
"ornithine aminotransferase activity",
"o... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.6.1.13",
"MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN",
"Reactome:R-HSA-70654 \"ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]\"",
"Reactome:R-HSA-70666 \"glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]\"",
"RHEA:13877",
... | [
"GO:0008483"
] | [] | [] | [] | [
"GO:0008483"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.6.1.13",
"skos:exactMatch MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN",
"skos:exactMatch RHEA:13877",
"skos:narrowMatch RHEA:25160",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25975\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/... | null | null | false | true | 7 |
GO:0004588 | 4,588 | orotate phosphoribosyltransferase activity | molecular_function | Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. | [
"EC:2.4.2.10"
] | null | [
"OPRT activity",
"OPRTase activity",
"orotate phosphoribosyl pyrophosphate transferase activity",
"orotic acid phosphoribosyltransferase activity",
"orotidine 5'-monophosphate pyrophosphorylase activity",
"orotidine monophosphate pyrophosphorylase activity",
"orotidine phosphoribosyltransferase activity... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.2.10",
"MetaCyc:OROPRIBTRANS-RXN",
"Reactome:R-HSA-73567 \"UMPS dimer transfers phosphoribosyl group to ORO to form OMP\"",
"RHEA:10380"
] | [
"GO:0016763"
] | [] | [] | [] | [
"GO:0016763"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.2.10",
"skos:exactMatch RHEA:10380",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004589 | 4,589 | dihydroorotate dehydrogenase (NAD+) activity | molecular_function | Catalysis of the reaction: (S)-dihydroorotate + NAD+ = H+ + NADH + orotate. | [
"RHEA:13513"
] | null | [
"(S)-dihydroorotate:NAD+ oxidoreductase activity",
"orotate reductase (NADH) activity"
] | [
"RELATED",
"EXACT"
] | [] | [] | [
"EC:1.3.1.14",
"KEGG_REACTION:R01869",
"MetaCyc:OROTATE-REDUCTASE-NADH-RXN",
"RHEA:13513"
] | [
"GO:0004152",
"GO:0016628"
] | [] | [] | [] | [
"GO:0004152",
"GO:0016628"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.3.1.14",
"skos:exactMatch RHEA:13513",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23786\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27180\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontol... | null | null | false | true | 9 |
GO:0004590 | 4,590 | orotidine-5'-phosphate decarboxylase activity | molecular_function | Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP. | [
"EC:4.1.1.23",
"RHEA:11596"
] | null | [
"ODCase activity",
"OMP decarboxylase activity",
"OMP-DC",
"OMPdcase activity",
"orotate decarboxylase activity",
"orotate monophosphate decarboxylase activity",
"orotic decarboxylase activity",
"orotidine 5'-phosphate decarboxylase activity",
"orotidine monophosphate decarboxylase activity",
"oro... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.1.1.23",
"KEGG_REACTION:R00965",
"MetaCyc:OROTPDECARB-RXN",
"Reactome:R-HSA-73564 \"UMPS dimer decarboxylates OMP to UMP\"",
"RHEA:11596"
] | [
"GO:0016831"
] | [] | [] | [] | [
"GO:0016831"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.1.23",
"skos:exactMatch RHEA:11596",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.