LiteFold/GO · Datasets at Hugging Face

GO:0004591

4,591

oxoglutarate dehydrogenase (succinyl-transferring) activity

molecular_function

Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H+ = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2.

[ "RHEA:12188" ]

null

[ "2-ketoglutarate dehydrogenase activity", "2-oxoglutarate dehydrogenase activity", "2-oxoglutarate: lipoate oxidoreductase activity", "2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)", "2-oxoglutarate:lipoamide 2-oxidored...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED" ]

[]

[ "EC:1.2.4.2", "MetaCyc:2OXOGLUTDECARB-RXN", "Reactome:R-HSA-71401 \"OGDH dimer decarboxylates 2-OG\"", "RHEA:12188" ]

[ "GO:0016624" ]

[]

[ "GO:0016624" ]

[]

[ "skos:broadMatch EC:1.2.1.105", "skos:broadMatch KEGG_REACTION:R08549", "skos:broadMatch MetaCyc:2OXOGLUTARATEDEH-RXN", "skos:broadMatch RHEA:27786", "skos:exactMatch EC:1.2.4.2", "skos:exactMatch MetaCyc:2OXOGLUTDECARB-RXN", "skos:exactMatch RHEA:12188", "term_tracker_item \"https://github.com/geneon...

null

false

true

2

GO:0004592

4,592

pantoate-beta-alanine ligase activity

molecular_function

Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.

[ "EC:6.3.2.1" ]

null

[ "(R)-pantoate:beta-alanine ligase (AMP-forming)", "D-pantoate:beta-alanine ligase (AMP-forming)", "pantoate-activating enzyme activity", "pantoic-activating enzyme activity", "pantothenate synthetase activity" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:6.3.2.1", "MetaCyc:PANTOATE-BETA-ALANINE-LIG-RXN", "RHEA:10912" ]

[ "GO:0016881" ]

[]

[ "GO:0016881" ]

[]

[ "skos:exactMatch EC:6.3.2.1", "skos:exactMatch RHEA:10912", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

4

GO:0004593

4,593

pantothenase activity

molecular_function

Catalysis of the reaction: (R)-pantothenate + H2O = (R)-pantoate + beta-alanine.

[ "EC:3.5.1.22", "RHEA:12448" ]

null

[ "(R)-pantothenate amidohydrolase activity", "pantothenate amidohydrolase activity", "pantothenate hydrolase activity" ]

[ "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:3.5.1.22", "KEGG_REACTION:R02474", "MetaCyc:PANTOTHENASE-RXN", "RHEA:12448" ]

[ "GO:0016811" ]

[]

[ "GO:0016811" ]

[]

[ "skos:exactMatch EC:3.5.1.22", "skos:exactMatch RHEA:12448", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

1

GO:0004595

4,595

pantetheine-phosphate adenylyltransferase activity

molecular_function

Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate.

[ "EC:2.7.7.3", "RHEA:19801" ]

null

[ "3'-dephospho-CoA pyrophosphorylase activity", "ATP:pantetheine-4'-phosphate adenylyltransferase activity", "ATP:pantetheine-phosphate adenylyltransferase activity", "dephospho-CoA diphosphorylase activity", "dephospho-CoA pyrophosphorylase activity", "dephospho-coenzyme A pyrophosphorylase activity", "...

[ "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED" ]

[]

[ "EC:2.7.7.3", "KEGG_REACTION:R03035", "MetaCyc:PANTEPADENYLYLTRAN-RXN", "Reactome:R-HSA-196754 \"COASY transfers an adenylyl group from ATP to PPANT\"", "RHEA:19801" ]

[ "GO:0070566" ]

[]

[ "GO:0070566" ]

[]

[ "skos:exactMatch EC:2.7.7.3", "skos:exactMatch RHEA:19801", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

1

GO:0004596

4,596

protein-N-terminal amino-acid acetyltransferase activity

molecular_function

Catalysis of the reaction: acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] = CoA + H+ + N-terminal Nalpha-acetyl-L-alpha-aminoacyl-[protein].

[ "PMID:30054468", "RHEA:21028" ]

null

[ "acetyl-CoA:peptide alpha-N-acetyltransferase activity", "acetyl-CoA:peptide nalpha-acetyltransferase activity", "amino-terminal amino acid-acetylating enzyme activity", "beta-endorphin acetyltransferase activity", "N(alpha)-acetyltransferase activity", "nalpha-acetyltransferase activity", "NAT activity...

[ "EXACT", "EXACT", "RELATED", "NARROW", "RELATED", "EXACT", "RELATED", "RELATED", "EXACT", "EXACT" ]

[]

[ "EC:2.3.1.255", "Reactome:R-HSA-6814090 \"NatC acetylates ARFFRP1\"", "RHEA:21028", "RHEA:50508", "RHEA:50512", "RHEA:50516", "RHEA:57320", "RHEA:75243", "RHEA:75247" ]

[ "GO:0034212" ]

[]

[ "GO:0034212" ]

[]

[ "skos:exactMatch EC:2.3.1.255", "skos:exactMatch RHEA:21028", "skos:narrowMatch RHEA:50508", "skos:narrowMatch RHEA:50512", "skos:narrowMatch RHEA:50516", "skos:narrowMatch RHEA:57320", "skos:narrowMatch RHEA:75243", "skos:narrowMatch RHEA:75247", "term_tracker_item \"https://github.com/geneontology...

null

false

true

7

GO:0004598

4,598

peptidylamidoglycolate lyase activity

molecular_function

Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate.

[ "EC:4.3.2.5" ]

null

[ "alpha-hydroxyglycine amidating dealkylase activity", "HGAD", "PAL", "peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity", "peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)", "peptidylamidoglycolate peptidylamide-lyase activity", "PGL" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:4.3.2.5", "MetaCyc:PEPTIDYLAMIDOGLYCOLATE-LYASE-RXN", "RHEA:20924" ]

[ "GO:0016842", "GO:0140096" ]

[]

[ "GO:0016842", "GO:0140096" ]

[]

[ "skos:exactMatch EC:4.3.2.5", "skos:exactMatch RHEA:20924", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

5

GO:0004600

4,600

obsolete cyclophilin

molecular_function

OBSOLETE. A protein to which cyclosporin A (an immunosuppressant) binds. Possesses peptidyl-prolyl isomerase activity.

[ "EC:5.2.1.8", "ISBN:0198506732" ]

This term was made obsolete because it does not represent a molecular function.

[ "cyclophilin" ]

[ "EXACT" ]

[]

[ "GO:0003755", "GO:0016018" ]

[]

null

true

2

GO:0004601

4,601

peroxidase activity

molecular_function

Catalysis of the reaction: a reduced substrate + ROOH = an oxidized substrate + ROH + H2O.

[ "PMID:33992367" ]

null

[ "bacterial catalase-peroxidase activity", "donor:hydrogen-peroxide oxidoreductase activity", "eosinophil peroxidase activity", "extensin peroxidase", "guaiacol peroxidase", "heme peroxidase", "horseradish peroxidase (HRP)", "japanese radish peroxidase", "lactoperoxidase activity", "MPO", "myelop...

[ "NARROW", "RELATED", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "RELATED", "NARROW", "RELATED", "EXACT", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW" ]

[ "GO:0016685", "GO:0016686", "GO:0016687", "GO:0016693" ]

[ "goslim_metagenomics" ]

[ "EC:1.11.1.-", "KEGG_REACTION:R03532", "Reactome:R-HSA-1222346 \"AhpC reduces H2O2\"", "Reactome:R-HSA-140359 \"PGG2 is reduced to PGH2 by PTGS1\"", "Reactome:R-HSA-2309773 \"PGG2 is reduced to PGH2 by PTGS2\"", "Reactome:R-HSA-2559639 \"Collagen type IV sulfilimine cross-linking by peroxidasin\"", "Rea...

[ "GO:0016209", "GO:0016684" ]

[]

[ "GO:0016209", "GO:0016684" ]

[]

[ "skos:exactMatch EC:1.11.1.-", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23121\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25776\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", ...

null

false

true

9

GO:0004602

4,602

glutathione peroxidase activity

molecular_function

Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O.

[ "EC:1.11.1.9", "PMID:36771108" ]

null

[ "glutathione:hydrogen-peroxide oxidoreductase activity", "GSH peroxidase activity", "non-selenium glutathione peroxidase activity", "reduced glutathione peroxidase activity", "selenium-glutathione peroxidase activity" ]

[ "RELATED", "RELATED", "NARROW", "RELATED", "RELATED" ]

[ "GO:0016224" ]

[]

[ "EC:1.11.1.9", "MetaCyc:GLUTATHIONE-PEROXIDASE-RXN", "Reactome:R-HSA-2161791 \"15S-HpETE is reduced to 15S-HETE by GPX1/2/4\"", "Reactome:R-HSA-2161946 \"5S-HpETE is reduced to 5S-HETE by GPX1/2/4\"", "Reactome:R-HSA-2161959 \"12R-HpETE is reduced to 12R-HETE by GPX1/2/4\"", "Reactome:R-HSA-2161999 \"12S-...

[ "GO:0004601" ]

[]

[ "GO:0004601" ]

[]

[ "skos:exactMatch EC:1.11.1.9", "skos:exactMatch RHEA:16833", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25498\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

8

GO:0004603

4,603

phenylethanolamine N-methyltransferase activity

molecular_function

Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.

[ "EC:2.1.1.28" ]

null

[ "noradrenalin N-methyltransferase activity", "noradrenaline N-methyltransferase activity", "norepinephrine methyltransferase activity", "norepinephrine N-methyltransferase activity", "phenethanolamine methyltransferase activity", "phenethanolamine N-methyltransferase activity", "S-adenosyl-L-methionine:...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.1.1.28", "MetaCyc:2.1.1.28-RXN", "Reactome:R-HSA-209903 \"Noradrenaline is converted to adrenaline\"", "RHEA:12176" ]

[ "GO:0008170", "GO:0008757" ]

[]

[ "GO:0008170", "GO:0008757" ]

[]

[ "skos:exactMatch EC:2.1.1.28", "skos:exactMatch RHEA:12176", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

9

GO:0004604

4,604

phosphoadenylyl-sulfate reductase (thioredoxin) activity

molecular_function

Catalysis of the reaction: adenosine 3',5'-diphosphate + H+ + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS.

[ "EC:1.8.4.8", "RHEA:11724" ]

null

[ "3'-phosphoadenylylsulfate reductase activity", "adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)", "adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)", "PAdoPS reduc...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED" ]

[]

[ "EC:1.8.4.8", "KEGG_REACTION:R02021", "MetaCyc:1.8.4.8-RXN", "RHEA:11724" ]

[ "GO:0016671" ]

[]

[ "GO:0016671" ]

[]

[ "skos:exactMatch EC:1.8.4.8", "skos:exactMatch RHEA:11724", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

3

GO:0004605

4,605

phosphatidate cytidylyltransferase activity

molecular_function

Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

[ "EC:2.7.7.41" ]

null

[ "CDP diglyceride pyrophosphorylase activity", "CDP-DG", "CDP-diacylglyceride synthetase activity", "CDP-diacylglycerol synthase activity", "CDP-diglyceride diphosphorylase activity", "CDP-diglyceride pyrophosphorylase activity", "CDP-diglyceride synthase activity", "CDP-diglyceride synthetase activity...

[ "RELATED", "RELATED", "RELATED", "EXACT", "EXACT", "EXACT", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.7.7.41", "MetaCyc:CDPDIGLYSYN-RXN", "Reactome:R-HSA-1483121 \"PA is converted to CDP-DAG by CDS1\"", "Reactome:R-HSA-1483165 \"PA is converted to CDP-DAG by CDS2\"", "RHEA:16229", "RHEA:45652", "RHEA:45664", "RHEA:45668" ]

[ "GO:0070567" ]

[]

[ "GO:0070567" ]

[]

[ "skos:exactMatch EC:2.7.7.41", "skos:exactMatch RHEA:16229", "skos:narrowMatch RHEA:45652", "skos:narrowMatch RHEA:45664", "skos:narrowMatch RHEA:45668", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

9

GO:0004607

4,607

phosphatidylcholine-sterol O-acyltransferase activity

molecular_function

Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine.

[ "EC:2.3.1.43" ]

null

[ "LCAT (lecithin-cholesterol acyltransferase)", "LCAT activity", "lecithin--cholesterol acyltransferase activity", "lecithin:cholesterol acyltransferase activity", "phosphatidylcholine:sterol O-acyltransferase activity", "phospholipid--cholesterol acyltransferase activity" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.3.1.43", "MetaCyc:2.3.1.43-RXN", "Reactome:R-HSA-264695 \"cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)\"", "RHEA:21204", "RHEA:34087" ]

[ "GO:0008374" ]

[]

[ "GO:0008374" ]

[]

[ "skos:exactMatch EC:2.3.1.43", "skos:exactMatch RHEA:21204", "skos:narrowMatch RHEA:34087", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

9

GO:0004608

4,608

phosphatidylethanolamine N-methyltransferase activity

molecular_function

Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H+ + phosphatidyl-N-methylethanolamine.

[ "EC:2.1.1.17", "RHEA:11164" ]

null

[ "lipid methyl transferase activity", "LMTase activity", "PEMT", "phosphatidylethanolamine methyltransferase activity", "phosphatidylethanolamine-N-methylase activity", "phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity", "S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltr...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.1.1.17", "KEGG_REACTION:R02056", "MetaCyc:2.1.1.17-RXN", "Reactome:R-HSA-1483174 \"PE is methylated to PC by PEMT\"", "RHEA:11164", "RHEA:70619", "RHEA:70739", "RHEA:70751", "RHEA:70763" ]

[ "GO:0008170", "GO:0008757" ]

[]

[ "GO:0008170", "GO:0008757" ]

[]

[ "skos:exactMatch EC:2.1.1.17", "skos:exactMatch RHEA:11164", "skos:narrowMatch RHEA:70619", "skos:narrowMatch RHEA:70739", "skos:narrowMatch RHEA:70751", "skos:narrowMatch RHEA:70763", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

3

GO:0004609

4,609

phosphatidylserine decarboxylase activity

molecular_function

Catalysis of the reaction: H+ + phosphatidyl-L-serine = CO2 + phosphatidylethanolamine.

[ "EC:4.1.1.65", "RHEA:20828" ]

null

[ "phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)", "phosphatidyl-L-serine carboxy-lyase activity", "PS decarboxylase activity" ]

[ "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:4.1.1.65", "KEGG_REACTION:R02055", "MetaCyc:PHOSPHASERDECARB-RXN", "Reactome:R-HSA-1483212 \"PS is decarboxylated to PE by PISD\"", "RHEA:20828" ]

[ "GO:0016831" ]

[]

[ "GO:0016831" ]

[]

[ "skos:exactMatch EC:4.1.1.65", "skos:exactMatch RHEA:20828", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

5

GO:0004610

4,610

phosphoacetylglucosamine mutase activity

molecular_function

Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.

[ "EC:5.4.2.3", "RHEA:23804" ]

null

[ "acetylaminodeoxyglucose phosphomutase activity", "acetylglucosamine phosphomutase activity", "N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity", "N-acetyl-D-glucosamine 1,6-phosphomutase activity", "N-acetylglucosamine-phosphate mutase activity", "phospho-N-acetylglucosamine mutase activity" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:5.4.2.3", "KEGG_REACTION:R08193", "MetaCyc:PHOSACETYLGLUCOSAMINEMUT-RXN", "Reactome:R-HSA-446185 \"Isomerization of GlcNAc6P to GlcNAc1P\"", "RHEA:23804" ]

[ "GO:0016868" ]

[]

[ "GO:0016868" ]

[]

[ "skos:exactMatch EC:5.4.2.3", "skos:exactMatch RHEA:23804", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

8

GO:0004611

4,611

phosphoenolpyruvate carboxykinase activity

molecular_function

Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products.

[ "GOC:curators" ]

null

[ "PEP carboxykinase activity", "PEPCK activity", "phosphopyruvate carboxylase activity" ]

[ "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:0016831" ]

[]

[ "GO:0016831" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28070\" xsd:anyURI" ]

null

false

true

6

GO:0004612

4,612

phosphoenolpyruvate carboxykinase (ATP) activity

molecular_function

Catalysis of the reaction: ATP + oxaloacetate = ADP + CO2 + H+ + phosphoenolpyruvate.

[ "EC:4.1.1.49", "RHEA:18617" ]

null

[ "ATP:oxaloacetate carboxy-lyase (transphosphorylating)", "ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)", "PEPCK (ATP)", "PEPK", "phosphoenolpyruvate carboxylase (ATP)", "phosphoenolpyruvic carboxykinase", "phosphopyruvate carboxykinase", "phosphopyruvate carboxyki...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "BROAD", "BROAD", "RELATED", "RELATED" ]

[]

[ "EC:4.1.1.49", "KEGG_REACTION:R00341", "MetaCyc:PEPCARBOXYKIN-RXN", "RHEA:18617" ]

[ "GO:0004611" ]

[]

[ "GO:0004611" ]

[]

[ "skos:exactMatch EC:4.1.1.49", "skos:exactMatch RHEA:18617", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

7

GO:0004613

4,613

phosphoenolpyruvate carboxykinase (GTP) activity

molecular_function

Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.

[ "EC:4.1.1.32" ]

null

[ "GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)", "GTP:oxaloacetate carboxy-lyase (transphosphorylating)", "phosphoenolpyruvate carboxylase (GTP)", "phosphoenolpyruvic carboxykinase", "phosphoenolpyruvic carboxykinase (GTP)", "phosphoenolpyruvic carboxylase (GTP)", "phosphopyru...

[ "RELATED", "RELATED", "EXACT", "BROAD", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:4.1.1.32", "MetaCyc:4.1.1.32-RXN", "Reactome:R-HSA-372819 \"PCK2 phosphorylates OA to yield PEP\"", "Reactome:R-HSA-70241 \"PCK1 phosphorylates OA to yield PEP\"", "RHEA:10388" ]

[ "GO:0004611" ]

[]

[ "GO:0004611" ]

[]

[ "skos:exactMatch EC:4.1.1.32", "skos:exactMatch RHEA:10388", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

5

GO:0004614

4,614

phosphoglucomutase activity

molecular_function

Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.

[ "EC:5.4.2.2" ]

null

[ "alpha-D-glucose 1,6-phosphomutase activity", "glucose phosphomutase activity", "phosphoglucose mutase activity" ]

[ "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:5.4.2.2", "MetaCyc:PHOSPHOGLUCMUT-RXN", "Reactome:R-HSA-5609939 \"Defective PGM1 does not isomerise G6P to G1P\"", "Reactome:R-HSA-9638125 \"PGM1:Mg2+ isomerises G1P to G6P\"", "Reactome:R-HSA-9638127 \"PGM1:Mg2+ isomerises G6P to G1P\"", "RHEA:23536" ]

[ "GO:0016868" ]

[]

[ "GO:0016868" ]

[]

[ "skos:exactMatch EC:5.4.2.2", "skos:exactMatch RHEA:23536", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

4

GO:0004615

4,615

phosphomannomutase activity

molecular_function

Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

[ "EC:5.4.2.8", "RHEA:11140" ]

null

[ "alpha-D-mannose 1,6-phosphomutase activity", "D-mannose 1,6-phosphomutase activity", "mannose phosphomutase activity", "phosphomannose mutase activity" ]

[ "RELATED", "RELATED", "RELATED", "RELATED" ]

[ "GO:0008971" ]

[]

[ "EC:5.4.2.8", "KEGG_REACTION:R01818", "MetaCyc:PHOSMANMUT-RXN", "Reactome:R-HSA-3781926 \"Defective PMM2 does not isomerise Man6P to Man1P\"", "Reactome:R-HSA-446201 \"PMM1,2 isomerise Man6P to Man1P\"", "RHEA:11140" ]

[ "GO:0016868" ]

[]

[ "GO:0016868" ]

[]

[ "skos:exactMatch EC:5.4.2.8", "skos:exactMatch RHEA:11140", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

3

GO:0004616

4,616

phosphogluconate dehydrogenase (decarboxylating) activity

molecular_function

Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+.

[ "EC:1.1.1.44" ]

null

[ "6-phospho-D-gluconate dehydrogenase activity", "6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)", "6-phosphogluconate dehydrogenase (decarboxylating)", "6-phosphogluconic carboxylase activity", "6-phosphogluconic dehydrogenase activity", "6PGD activity", "phosphogluconic acid dehydrogena...

[ "RELATED", "RELATED", "RELATED", "RELATED", "BROAD", "RELATED", "RELATED" ]

[]

[ "EC:1.1.1.44", "MetaCyc:RXN-9952", "Reactome:R-HSA-71299 \"PGD decarboxylates 6-phospho-D-gluconate\"", "RHEA:10116" ]

[ "GO:0016616" ]

[]

[ "GO:0016616" ]

[]

[ "skos:exactMatch EC:1.1.1.44", "skos:exactMatch RHEA:10116", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25816\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

2

GO:0004617

4,617

phosphoglycerate dehydrogenase activity

molecular_function

Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.

[ "EC:1.1.1.95" ]

null

[ "3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity", "3-phosphoglycerate dehydrogenase activity", "3-phosphoglycerate:NAD+ 2-oxidoreductase activity", "3-phosphoglyceric acid dehydrogenase activity", "3PHP reductase activity", "alpha-KG reductase activity", "alpha-phosphoglycerate dehydrogenase activ...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:1.1.1.95", "MetaCyc:PGLYCDEHYDROG-RXN", "Reactome:R-HSA-977348 \"PHGDH tetramer dehydrogenates 3PG\"", "RHEA:12641" ]

[ "GO:0016616" ]

[]

[ "GO:0016616" ]

[]

[ "skos:exactMatch EC:1.1.1.95", "skos:exactMatch RHEA:12641", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

4

GO:0004618

4,618

phosphoglycerate kinase activity

molecular_function

Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H+.

[ "EC:2.7.2.3", "RHEA:14801" ]

null

[ "3-PGK", "3-phosphoglycerate kinase activity", "3-phosphoglycerate phosphokinase activity", "3-phosphoglyceric acid kinase activity", "3-phosphoglyceric acid phosphokinase activity", "3-phosphoglyceric kinase activity", "ATP-3-phospho-D-glycerate-1-phosphotransferase activity", "ATP:3-phospho-D-glycer...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.7.2.3", "KEGG_REACTION:R01512", "MetaCyc:PHOSGLYPHOS-RXN", "Reactome:R-HSA-70486 \"PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG\"", "Reactome:R-HSA-71850 \"PGK complexes dephosphorylate 1,3BPG\"", "RHEA:14801" ]

[ "GO:0016301", "GO:0016774" ]

[]

[ "GO:0016301", "GO:0016774" ]

[]

[ "skos:exactMatch EC:2.7.2.3", "skos:exactMatch RHEA:14801", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

2

GO:0004619

4,619

phosphoglycerate mutase activity

molecular_function

Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.

[ "RHEA:15901" ]

null

[ "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity", "2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity", "D-phosphoglycerate 2,3-phosphomutase activity", "PGA mutase activity", "PGAM activity", "PGM", "phosphoglycerate phosphomutase activity", "phosphoglyceromutase...

[ "NARROW", "NARROW", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED" ]

[]

[ "EC:5.4.2.11", "EC:5.4.2.12", "KEGG_REACTION:R01516", "MetaCyc:3PGAREARR-RXN", "MetaCyc:RXN-15513", "Reactome:R-HSA-71445 \"PGAM dimers isomerise 2PG to 3PG\"", "Reactome:R-HSA-71654 \"PGAM dimers isomerise 3PG to 2PG\"", "RHEA:15901" ]

[ "GO:0016868" ]

[]

[ "GO:0016868" ]

[]

[ "skos:exactMatch RHEA:15901", "skos:narrowMatch EC:5.4.2.11", "skos:narrowMatch EC:5.4.2.12", "skos:narrowMatch MetaCyc:3PGAREARR-RXN", "skos:narrowMatch MetaCyc:RXN-15513", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24905\" xsd:anyURI", "term_tracker_item \"https://github.c...

null

false

true

8

GO:0004620

4,620

glycerophospholipase activity

molecular_function

Catalysis of the hydrolysis of a glycerophospholipid.

[ "PMID:30109646" ]

null

[ "glycerophospholipid hydrolase activity", "phospholipase activity" ]

[ "EXACT", "RELATED" ]

[]

[ "goslim_chembl" ]

[ "Reactome:R-HSA-6786650 \"DDHD1,2 hydrolyse PA\"", "Reactome:R-HSA-6792445 \"LIPH, I hydrolyse PA to 2-acyl LPA\"" ]

[ "GO:0120569" ]

[]

[ "GO:0120569" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21843\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30258\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31030\" xsd:anyURI" ]

null

false

true

5

GO:0004621

4,621

GPI anchor phospholipase D activity

molecular_function

Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol, by cleavage of the second phosphodiester bond between the phosphate and phospholipid.

[ "PMID:2760042", "RHEA:86263" ]

null

[ "glycoprotein phospholipase D activity", "glycoprotein-phosphatidylinositol phosphatidohydrolase activity", "glycosylphosphatidyl inositol-anchor protein phospholipase D activity", "GPI-PLD activity" ]

[ "BROAD", "EXACT", "EXACT", "EXACT" ]

[]

[ "Reactome:R-HSA-8940388 \"GPLD1 hydrolyses GPI-anchors from proteins\"", "RHEA:86263" ]

[ "GO:0004630" ]

[]

[ "GO:0004630" ]

[]

[ "skos:broadMatch EC:3.1.4.50", "skos:exactMatch RHEA:86263", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28868\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31078\" xsd:anyURI" ]

null

false

true

3

GO:0004622

4,622

phosphatidylcholine lysophospholipase A1 activity

molecular_function

Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine.

[ "RHEA:15177" ]

null

[ "2-lysophosphatidylcholine acylhydrolase activity", "lecithinase B activity", "lecitholipase activity", "lysolecithinase activity", "lysophopholipase L2", "lysophosphatidase activity", "lysophosphatidylcholine hydrolase activity", "lysophospholipase A1", "lysophospholipase activity", "phosphatidas...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "BROAD", "RELATED", "EXACT", "RELATED" ]

[ "GO:0045126" ]

[ "goslim_chembl" ]

[ "EC:3.1.1.5", "MetaCyc:LYSOPHOSPHOLIPASE-RXN", "Reactome:R-HSA-1482545 \"2-acyl LPE is hydrolyzed to GPETA by PLA2G4C\"", "Reactome:R-HSA-1482571 \"1-acyl LPE is hydrolyzed to GPETA by PLA2G4C\"", "Reactome:R-HSA-1482612 \"2-acyl LPC is hydrolyzed to GPCho by PLA2[8]\"", "Reactome:R-HSA-1482629 \"2-acyl L...

[ "GO:0120558" ]

[]

[ "GO:0120558" ]

[]

[ "skos:exactMatch EC:3.1.1.5", "skos:exactMatch RHEA:15177", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27557\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28339\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontolo...

null

false

true

2

GO:0004623

4,623

A2-type glycerophospholipase activity

molecular_function

A glycerophospholipase activity that cleaves the fatty acid attached to the sn-2 position of the glycerol group of a glycerophospholipid. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.

[ "PMID:30109646" ]

null

[ "cytosolic phospholipase A2 activity", "lecithinase A activity", "phosphatidase activity", "phosphatidolipase activity", "phosphatidylcholine 2-acylhydrolase activity", "phospholipase A2 activity", "phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)", "phospholipase A2 activity c...

[ "NARROW", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "NARROW", "NARROW", "NARROW" ]

[ "GO:0102567", "GO:0102568" ]

[ "goslim_chembl" ]

[ "EC:3.1.1.4", "MetaCyc:PHOSPHOLIPASE-A2-RXN", "MetaCyc:RXN-15065", "MetaCyc:RXN-15067", "Reactome:R-HSA-1482604 \"PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)\"", "Reactome:R-HSA-1482656 \"PA is hydrolysed to 1-acyl LPA by PLA2[1]\"", "Reactome:R-HSA-1482679 \"PA is hydrolysed to 1-acyl LPA by PLA2G2A...

[ "GO:0004620", "GO:0052689" ]

[]

[ "GO:0004620", "GO:0052689" ]

[]

[ "skos:exactMatch EC:3.1.1.4", "skos:narrowMatch MetaCyc:RXN-15065", "skos:narrowMatch RHEA:15801", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21259\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28339\" xsd:anyURI", "term_tracker_item \"...

null

false

true

9

GO:0004624

4,624

obsolete secreted phospholipase A2 activity

molecular_function

OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion.

[ "EC:3.1.1.4" ]

This term was made obsolete because it represents component and function information.

[ "secreted phospholipase A2 activity" ]

[ "EXACT" ]

[]

[ "GO:0004623", "GO:0005576" ]

[]

null

true

2

GO:0004625

4,625

obsolete calcium-dependent secreted phospholipase A2 activity

molecular_function

OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion.

[ "EC:3.1.1.4" ]

This term was made obsolete because it represents component and function information.

[ "calcium-dependent secreted phospholipase A2 activity" ]

[ "EXACT" ]

[]

[ "GO:0004623", "GO:0005576" ]

[]

null

true

7

GO:0004626

4,626

obsolete cytosolic phospholipase A2 activity

molecular_function

OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion.

[ "EC:3.1.1.4" ]

This term was made obsolete because it represents component and function information.

[ "cytosolic phospholipase A2 activity" ]

[ "EXACT" ]

[]

[ "GO:0004623", "GO:0005829" ]

[]

null

true

7

GO:0004628

4,628

obsolete calcium-independent cytosolic phospholipase A2 activity

molecular_function

OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion.

[ "EC:3.1.1.4" ]

This term was made obsolete because it represents component and function information.

[ "calcium-independent cytosolic phospholipase A2 activity" ]

[ "EXACT" ]

[]

[ "GO:0004623", "GO:0005829" ]

[]

null

true

6

GO:0004629

4,629

C-type glycerophospholipase activity

molecular_function

A glycerophospholipase activity that cleaves the first phosphodiester bond between the phosphate and glycerol, producing a mono- or a diacylglycerol, depending on whether the substrate is a lysoglycerophospholipid or a glycerophospholipid.

[ "PMID:30109646" ]

null

[ "C-type phospholipase activity", "phosphatidase C", "phospholipase C activity" ]

[ "EXACT", "RELATED", "EXACT" ]

[ "GO:0042298" ]

[]

[ "Reactome:R-HSA-1112666 \"BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate\"", "Reactome:R-HSA-114688 \"PLC-beta hydrolyses PIP2 to DAG and IP3\"", "Reactome:R-HSA-114689 \"PLC gamma 2-mediated PIP2 hydrolysis\"", "Reactome:R-HSA-398...

[ "GO:0004620", "GO:0008081" ]

[]

[ "GO:0004620", "GO:0008081" ]

[]

[ "skos:broadMatch EC:3.1.4.3", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23316\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31049\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31078\" xsd:anyURI" ]

null

false

true

7

GO:0004630

4,630

D-type glycerophospholipase activity

molecular_function

A glycerophospholipase activity that cleaves the second phosphodiester bond between the phosphate and phospholipid, releasing a phosphatidic acid.

[ "PMID:30109646" ]

null

[ "choline phosphatase activity", "D-type phospholipase activity", "lecithinase D activity", "lipophosphodiesterase II activity", "phosphatidylcholine phosphatidohydrolase activity", "phospholipase D activity" ]

[ "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "EXACT" ]

[]

[ "goslim_chembl" ]

[ "EC:3.1.4.4", "MetaCyc:PHOSCHOL-RXN", "Reactome:R-HSA-1483142 \"PC is transphosphatidylated to PG by PLD1-4/6\"", "Reactome:R-HSA-1483182 \"PC is hydrolyzed to PA and choline by PLD1/2\"", "Reactome:R-HSA-2029471 \"Hydrolysis of PC to PA by PLD\"", "RHEA:14445" ]

[ "GO:0004620", "GO:0008081" ]

[]

[ "GO:0004620", "GO:0008081" ]

[]

[ "skos:exactMatch EC:3.1.4.4", "skos:narrowMatch RHEA:14445", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31049\" xsd:anyURI" ]

null

false

true

7

GO:0004631

4,631

phosphomevalonate kinase activity

molecular_function

Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H+.

[ "EC:2.7.4.2", "RHEA:16341" ]

null

[ "5-phosphomevalonate kinase activity", "ATP:(R)-5-phosphomevalonate phosphotransferase activity", "ATP:5-phosphomevalonate phosphotransferase activity", "mevalonate phosphate kinase activity", "mevalonate-5-phosphate kinase activity", "mevalonic acid phosphate kinase activity" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.7.4.2", "KEGG_REACTION:R03245", "MetaCyc:PHOSPHOMEVALONATE-KINASE-RXN", "Reactome:R-HSA-191422 \"Mevalonate-5-phosphate is further phosphorylated\"", "RHEA:16341" ]

[ "GO:0016301", "GO:0016776" ]

[]

[ "GO:0016301", "GO:0016776" ]

[]

[ "skos:exactMatch EC:2.7.4.2", "skos:exactMatch RHEA:16341", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

3

GO:0004633

4,633

phosphopantothenoylcysteine decarboxylase activity

molecular_function

Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H+ = CO2 + pantetheine 4'-phosphate.

[ "EC:4.1.1.36", "RHEA:16793" ]

null

[ "4-phosphopantothenoyl-L-cysteine decarboxylase activity", "4-phosphopantotheoylcysteine decarboxylase activity", "N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity", "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)", "N-[(R)-4'-phosphopantothenoyl]-...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:4.1.1.36", "KEGG_REACTION:R03269", "MetaCyc:P-PANTOCYSDECARB-RXN", "Reactome:R-HSA-196840 \"3xPPCDC:3FMN decarboxylates PPC\"", "RHEA:16793" ]

[ "GO:0016831" ]

[]

[ "GO:0016831" ]

[]

[ "skos:exactMatch EC:4.1.1.36", "skos:exactMatch RHEA:16793", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

2

GO:0004634

4,634

phosphopyruvate hydratase activity

molecular_function

Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O.

[ "EC:4.2.1.11", "ISBN:0198506732" ]

null

[ "14-3-2-protein", "2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)", "2-phospho-D-glycerate hydro-lyase activity", "2-phospho-D-glycerate-hydrolase activity", "2-phosphoglycerate dehydratase activity", "2-phosphoglycerate enolase activity", "2-phosphoglyceric dehydratase activity", "en...

[ "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "NARROW", "RELATED" ]

[]

[ "EC:4.2.1.11", "MetaCyc:2PGADEHYDRAT-RXN", "Reactome:R-HSA-70494 \"Enolase dimers (ENO1,2,3) convert PEP to 2PG\"", "Reactome:R-HSA-71660 \"Enolase dimers dehydrates 2PG\"", "RHEA:10164" ]

[ "GO:0016836" ]

[]

[ "GO:0016836" ]

[]

[ "skos:exactMatch EC:4.2.1.11", "skos:exactMatch RHEA:10164", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

6

GO:0004635

4,635

phosphoribosyl-AMP cyclohydrolase activity

molecular_function

Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H2O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide.

[ "EC:3.5.4.19", "RHEA:20049" ]

null

[ "1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity", "phosphoribosyladenosine monophosphate cyclohydrolase activity", "PRAMP-cyclohydrolase activity" ]

[ "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:3.5.4.19", "KEGG_REACTION:R04037", "MetaCyc:HISTCYCLOHYD-RXN", "RHEA:20049" ]

[ "GO:0019238" ]

[]

[ "GO:0019238" ]

[]

[ "skos:exactMatch EC:3.5.4.19", "skos:exactMatch RHEA:20049", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

5

GO:0004637

4,637

phosphoribosylamine-glycine ligase activity

molecular_function

Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate.

[ "EC:6.3.4.13", "RHEA:17453" ]

null

[ "2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity", "5'-phosphoribosylglycinamide synthetase activity", "5-phospho-D-ribosylamine:glycine ligase (ADP-forming)", "GAR", "GAR synthetase activity", "GARS activity", "glycinamide ribonucleotide synthetase activity", "glycineamide ribonucleotid...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:6.3.4.13", "KEGG_REACTION:R04144", "MetaCyc:GLYRIBONUCSYN-RXN", "Reactome:R-HSA-73814 \"5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi\"", "RHEA:17453" ]

[ "GO:0016879" ]

[]

[ "GO:0016879" ]

[]

[ "skos:exactMatch EC:6.3.4.13", "skos:exactMatch RHEA:17453", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

3

GO:0004638

4,638

phosphoribosylaminoimidazole carboxylase activity

molecular_function

Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H+ = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.

[ "EC:4.1.1.21", "RHEA:10792" ]

null

[ "1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity", "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]", "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity", "5-amino-1-ribosylimidazole ...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:4.1.1.21", "KEGG_REACTION:R04209", "MetaCyc:AIRCARBOXY-RXN", "Reactome:R-HSA-73806 \"AIR + CO2 => CAIR\"", "RHEA:10792" ]

[ "GO:0016831" ]

[]

[ "GO:0016831" ]

[]

[ "skos:exactMatch EC:4.1.1.21", "skos:exactMatch RHEA:10792", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

9

GO:0004639

4,639

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

molecular_function

Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate.

[ "EC:6.3.2.6", "RHEA:22628" ]

null

[ "4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity", "4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity", "4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity", "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase ...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:6.3.2.6", "KEGG_REACTION:R04591", "MetaCyc:SAICARSYN-RXN", "Reactome:R-HSA-73805 \"CAIR + Aspartate + ATP => SAICAR + ADP + Pi\"", "RHEA:22628" ]

[ "GO:0016881" ]

[]

[ "GO:0016881" ]

[]

[ "skos:exactMatch EC:6.3.2.6", "skos:exactMatch RHEA:22628", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

7

GO:0004640

4,640

phosphoribosylanthranilate isomerase activity

molecular_function

Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

[ "RHEA:21540" ]

null

[ "IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)", "N-(5'-phosphoribosyl)anthranilate isomerase activity", "N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity", "N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity", "P...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:5.3.1.24", "KEGG_REACTION:R03509", "MetaCyc:PRAISOM-RXN", "RHEA:21540" ]

[ "GO:0016861" ]

[]

[ "GO:0016861" ]

[]

[ "skos:exactMatch EC:5.3.1.24", "skos:exactMatch RHEA:21540", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

6

GO:0004641

4,641

phosphoribosylformylglycinamidine cyclo-ligase activity

molecular_function

Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate.

[ "EC:6.3.3.1", "RHEA:23032" ]

null

[ "2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)", "2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)", "5'-aminoimidazole ribonucleotide synthetase activity", "AIR synthase activity", "AIR synthetase activity", "AIRS activity", "phosphoribosyl-aminoimi...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:6.3.3.1", "KEGG_REACTION:R04208", "MetaCyc:AIRS-RXN", "Reactome:R-HSA-73810 \"FGAM + ATP => AIR + ADP + Pi\"", "RHEA:23032" ]

[ "GO:0016882" ]

[]

[ "GO:0016882" ]

[]

[ "skos:exactMatch EC:6.3.3.1", "skos:exactMatch RHEA:23032", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

8

GO:0004642

4,642

phosphoribosylformylglycinamidine synthase activity

molecular_function

Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate.

[ "EC:6.3.5.3", "RHEA:17129" ]

null

[ "2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)", "5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)", "FGAM synthase activity", "FGAM synthetase activity", "FGAR amidotransferase activity", "FGARAT activity", "formylglycinamide ribonucloet...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:6.3.5.3", "KEGG_REACTION:R04463", "MetaCyc:FGAMSYN-RXN", "Reactome:R-HSA-73812 \"FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi\"", "RHEA:17129" ]

[ "GO:0016884" ]

[]

[ "GO:0016884" ]

[]

[ "skos:exactMatch EC:6.3.5.3", "skos:exactMatch RHEA:17129", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

2

GO:0004643

4,643

phosphoribosylaminoimidazolecarboxamide formyltransferase activity

molecular_function

Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide.

[ "EC:2.1.2.3" ]

null

[ "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity", "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity", "5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity", "5-amino-1-ribosyl...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.1.2.3", "MetaCyc:AICARTRANSFORM-RXN", "Reactome:R-HSA-73798 \"AICAR + 10-Formyl-THF => FAICAR + THF\"", "RHEA:22192" ]

[ "GO:0016742" ]

[]

[ "GO:0016742" ]

[]

[ "skos:exactMatch EC:2.1.2.3", "skos:exactMatch RHEA:22192", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

4

GO:0004645

4,645

1,4-alpha-oligoglucan phosphorylase activity

molecular_function

Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate.

[ "RHEA:41732" ]

null

[ "1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity", "1,4-alpha-glucan phosphorylase activity", "alpha-glucan phosphorylase", "amylopectin phosphorylase", "amylophosphorylase activity", "glucan phosphorylase", "glucosan phosphorylase", "granulose phosphorylase", "muscle phosphorylase...

[ "RELATED", "RELATED", "BROAD", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "RELATED", "NARROW", "NARROW" ]

[]

[ "EC:2.4.1.1", "MetaCyc:RXN0-5184", "RHEA:41732" ]

[ "GO:0016758" ]

[]

[ "GO:0016758" ]

[]

[ "skos:exactMatch EC:2.4.1.1", "skos:exactMatch RHEA:41732", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28070\" xsd:anyURI" ]

null

false

true

3

GO:0004648

4,648

O-phospho-L-serine:2-oxoglutarate transaminase activity

molecular_function

Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.

[ "RHEA:14329" ]

null

[ "3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity", "3-phosphoserine aminotransferase activity", "3PHP transaminase activity", "hydroxypyruvic phosphate--glutamic transaminase activity", "L-phosphoserine aminotransferase activity", "O-phospho-L-serine:2-oxoglutarate aminotransferase activity"...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "BROAD", "BROAD", "RELATED", "RELATED" ]

[ "GO:0004646" ]

[]

[ "EC:2.6.1.52", "MetaCyc:PSERTRANSAM-RXN", "Reactome:R-HSA-977333 \"PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA\"", "RHEA:14329" ]

[ "GO:0008483" ]

[]

[ "GO:0008483" ]

[]

[ "skos:exactMatch EC:2.6.1.52", "skos:exactMatch RHEA:14329", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31140\" xsd:anyURI" ]

null

false

true

3

GO:0004649

4,649

poly(ADP-ribose) glycohydrolase activity

molecular_function

Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.

[ "EC:3.2.1.143" ]

null

[]

[ "EC:3.2.1.143", "MetaCyc:3.2.1.143-RXN", "Reactome:R-HSA-5651828 \"PARG dePARylates PARP1,PARP2\"", "Reactome:R-HSA-8952903 \"ADPRHL2 hydrolyses poly(ADP-ribose)\"", "RHEA:52216" ]

[ "GO:0004553" ]

[]

[ "GO:0004553" ]

[]

[ "skos:exactMatch EC:3.2.1.143", "skos:exactMatch RHEA:52216", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

8

GO:0004650

4,650

polygalacturonase activity

molecular_function

Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans.

[ "EC:3.2.1.15" ]

null

[ "endo-D-galacturonase activity", "endo-polygalacturonase activity", "endogalacturonase activity", "endopolygalacturonase activity", "pectin depolymerase activity", "pectin hydrolase activity", "pectin polygalacturonase activity", "pectinase activity", "pectolase activity", "poly(1,4-alpha-D-galact...

[ "EXACT", "EXACT", "EXACT", "EXACT", "NARROW", "RELATED", "RELATED", "NARROW", "RELATED", "EXACT", "EXACT" ]

[]

[ "EC:3.2.1.15", "MetaCyc:RXN-2103" ]

[ "GO:0004553" ]

[]

[ "GO:0004553" ]

[]

[ "skos:exactMatch EC:3.2.1.15", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

4

GO:0004651

4,651

polynucleotide 5'-phosphatase activity

molecular_function

Catalysis of the reaction: a 5'-phosphopolynucleotide + H2O = a polynucleotide + phosphate.

[ "EC:3.1.3.33" ]

null

[ "5'-polynucleotidase activity", "polynucleotide 5'-phosphohydrolase activity", "polynucleotide 5'-triphosphatase activity" ]

[ "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:3.1.3.33", "MetaCyc:RXN-21861", "Reactome:R-HSA-77078 \"Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme\"", "Reactome:R-HSA-9923980 \"NS3 cleaves triphosphate moiety of genomic +ssRNA\"", "RHEA:67772", "RHEA:67776" ]

[ "GO:0016791" ]

[]

[ "GO:0016791" ]

[]

[ "skos:exactMatch EC:3.1.3.33", "skos:narrowMatch RHEA:67772", "skos:narrowMatch RHEA:67776", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25810\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26595\" xsd:anyURI", "term_tracker_item \"https:...

null

false

true

5

GO:0004652

4,652

obsolete polynucleotide adenylyltransferase activity

molecular_function

OBSOLETE. Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.

[ "EC:2.7.7.19" ]

This term was obsoleted because it represents the same activity as RNA adenylyltransferase activity ; GO:1990817.

[ "adenosine triphosphate:ribonucleic acid adenylyltransferase activity", "AMP polynucleotidylexotransferase activity", "ATP-polynucleotide adenylyltransferase activity", "ATP:polynucleotide adenylyltransferase activity", "ATP:polynucleotidylexotransferase activity", "NTP polymerase activity", "poly(A) hy...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:1990817" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24859\" xsd:anyURI" ]

null

true

1

GO:0004653

4,653

polypeptide N-acetylgalactosaminyltransferase activity

molecular_function

Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is th...

[ "EC:2.4.1.41", "ISBN:0879695595" ]

null

[ "glycoprotein acetylgalactosaminyltransferase activity", "polypeptide-N-acetylgalactosamine transferase activity", "protein-UDP acetylgalactosaminyltransferase activity", "UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity", "UDP-acetylgalactosamine:peptide-N-galactosaminyltransfe...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.4.1.41", "MetaCyc:2.4.1.41-RXN", "Reactome:R-HSA-5096532 \"Defective GALNT12 does not transfer GalNAc to mucins\"", "Reactome:R-HSA-5096537 \"Defective GALNT3 does not transfer GalNAc to mucins\"", "Reactome:R-HSA-8851619 \"GALNT3 transfers GalNAc to FGF23\"", "Reactome:R-HSA-913675 \"GALNTs transfe...

[ "GO:0008376", "GO:0140096" ]

[]

[ "GO:0008376", "GO:0140096" ]

[]

[ "skos:exactMatch EC:2.4.1.41", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

1

GO:0004654

4,654

polyribonucleotide nucleotidyltransferase activity

molecular_function

Catalysis of the reaction: RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.

[ "EC:2.7.7.8" ]

null

[ "nucleoside diphosphate:polynucleotidyl transferase activity", "polynucleotide phosphorylase activity", "polyribonucleotide phosphorylase activity", "polyribonucleotide:phosphate nucleotidyltransferase activity" ]

[ "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.7.7.8", "MetaCyc:2.7.7.8-RXN", "RHEA:22096" ]

[ "GO:0016779" ]

[]

[ "GO:0016779" ]

[]

[ "skos:exactMatch EC:2.7.7.8", "skos:exactMatch RHEA:22096", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

7

GO:0004655

4,655

porphobilinogen synthase activity

molecular_function

Catalysis of the reaction: 2 5-aminolevulinate = 2 H2O + H+ + porphobilinogen.

[ "EC:4.2.1.24", "RHEA:24064" ]

null

[ "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)", "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)", "5-levulinic acid dehydratase activity", "aminolevulinate dehydratase activity", "aminolevulinic dehydratase activity", "delta-aminol...

[ "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED" ]

[]

[ "EC:4.2.1.24", "KEGG_REACTION:R00036", "MetaCyc:PORPHOBILSYNTH-RXN", "Reactome:R-HSA-189439 \"ALAD condenses 2 dALAs to form PBG\"", "RHEA:24064" ]

[ "GO:0016836" ]

[]

[ "GO:0016836" ]

[]

[ "skos:exactMatch EC:4.2.1.24", "skos:exactMatch RHEA:24064", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

8

GO:0004656

4,656

procollagen-proline 4-dioxygenase activity

molecular_function

Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.

[ "EC:1.14.11.2" ]

null

[ "collagen proline hydroxylase activity", "hydroxylase, collagen proline activity", "peptidyl proline hydroxylase activity", "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity", "procollagen-proline,2-oxoglutarate-4-dioxygenase activity", "proline hydroxylase activity", ...

[ "RELATED", "RELATED", "BROAD", "RELATED", "EXACT", "BROAD", "RELATED", "BROAD", "BROAD", "BROAD", "BROAD", "BROAD", "RELATED", "RELATED", "BROAD", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:1.14.11.2", "KEGG_REACTION:R03219", "MetaCyc:1.14.11.2-RXN", "Reactome:R-HSA-1650808 \"Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines\"", "RHEA:18945" ]

[ "GO:0019798", "GO:0031545" ]

[]

[ "GO:0019798", "GO:0031545" ]

[]

[ "skos:exactMatch EC:1.14.11.2", "skos:exactMatch RHEA:18945", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

9

GO:0004657

4,657

proline dehydrogenase activity

molecular_function

Catalysis of the reaction: L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H+.

[ "RHEA:23784" ]

null

[ "L-proline dehydrogenase activity", "proline oxidase activity" ]

[ "RELATED", "EXACT" ]

[]

[ "EC:1.5.5.2", "MetaCyc:RXN-14903", "Reactome:R-HSA-6784224 \"PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate\"", "Reactome:R-HSA-8955817 \"PRODH2 oxidises HPRO to 1PYR-3OH-5COOH\"", "RHEA:23784" ]

[ "GO:0016649" ]

[]

[ "GO:0016649" ]

[]

[ "skos:exactMatch EC:1.5.5.2", "skos:exactMatch RHEA:23784", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23335\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29588\" xsd:anyURI" ]

null

false

true

6

GO:0004658

4,658

propionyl-CoA carboxylase activity

molecular_function

Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.

[ "EC:6.4.1.3" ]

null

[ "PCCase activity", "propanoyl-CoA:carbon-dioxide ligase (ADP-forming)", "propionyl coenzyme A carboxylase activity" ]

[ "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:6.4.1.3", "MetaCyc:PROPIONYL-COA-CARBOXY-RXN", "Reactome:R-HSA-71031 \"propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate\"", "RHEA:23720" ]

[ "GO:0016421" ]

[]

[ "GO:0016421" ]

[]

[ "skos:exactMatch EC:6.4.1.3", "skos:exactMatch RHEA:23720", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

5

GO:0004659

4,659

prenyltransferase activity

molecular_function

Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor).

[ "GOC:mah" ]

null

[]

[ "Reactome:R-HSA-6806674 \"UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)\"" ]

[ "GO:0016765" ]

[]

[ "GO:0016765" ]

[]

[ "skos:broadMatch EC:2.5.1.-", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25785\" xsd:anyURI" ]

null

false

true

4

GO:0004660

4,660

protein farnesyltransferase activity

molecular_function

Catalysis of the reaction: L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate.

[ "PMID:8621375", "RHEA:13345" ]

The catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. There is no relationship between this activity and farnesyltransferase activity, GO:0004311, where the catalyzed reaction forms (free) geranylgeranyl diphosphate.

[ "CAAX farnesyltransferase activity", "farnesyl-diphosphate:protein-cysteine farnesyltransferase activity", "FTase activity", "protein-cysteine farnesyltransferase activity" ]

[ "NARROW", "RELATED", "RELATED", "EXACT" ]

[ "GO:0018223" ]

[]

[ "EC:2.5.1.58", "MetaCyc:RXN-17573", "Reactome:R-HSA-2530501 \"FNTA:FNTB transfers FARN to GNGT1\"", "Reactome:R-HSA-9647978 \"pro-RAS proteins are farnesylated\"", "Reactome:R-HSA-9948016 \"FNTA:FNTB transfers farnesyl to GBP1\"", "RHEA:13345" ]

[ "GO:0008318" ]

[]

[ "GO:0008318" ]

[]

[ "skos:exactMatch EC:2.5.1.58", "skos:exactMatch RHEA:13345" ]

null

false

true

7

GO:0004661

4,661

protein geranylgeranyltransferase activity

molecular_function

Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.

[ "PMID:8621375" ]

null

[ "protein-cysteine geranylgeranyltransferase activity" ]

[ "EXACT" ]

[ "GO:0018224" ]

[]

[ "RHEA:21240" ]

[ "GO:0008318" ]

[]

[ "GO:0008318" ]

[]

[ "skos:exactMatch RHEA:21240", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26829\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

9

GO:0004662

4,662

CAAX-protein geranylgeranyltransferase activity

molecular_function

Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-te...

[ "EC:2.5.1.59", "PMID:8621375" ]

null

[ "geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity", "geranylgeranyltransferase type I activity", "GGTase-I activity", "GGTaseI activity", "protein geranylgeranyltransferase type I", "type I protein geranyl-geranyltransferase activity" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "RELATED", "RELATED" ]

[]

[ "EC:2.5.1.59", "MetaCyc:RXN-3701", "Reactome:R-HSA-9947999 \"FNTA:PGGT1B geranylgeranylates GBP2\"", "Reactome:R-HSA-9954195 \"FNTA:PGGT1B geranylgeranylates GBP5\"" ]

[ "GO:0004661" ]

[]

[ "GO:0004661" ]

[]

[ "skos:exactMatch EC:2.5.1.59", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25798\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

6

GO:0004663

4,663

Rab geranylgeranyltransferase activity

molecular_function

Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known subs...

[ "EC:2.5.1.60", "GOC:mah", "PMID:8621375" ]

null

[ "geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity", "GGTase-II activity", "GGTaseII activity", "protein geranylgeranyltransferase type II activity", "Rab-protein geranylgeranyltransferase activity", "RabGGTase activity", "type II protein geranyl-geranylt...

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "RELATED" ]

[]

[ "EC:2.5.1.60", "MetaCyc:RXN-19995", "MetaCyc:RXN-19996", "MetaCyc:RXN-19997" ]

[ "GO:0004661" ]

[]

[ "GO:0004661" ]

[]

[ "skos:exactMatch EC:2.5.1.60", "skos:narrowMatch MetaCyc:RXN-19995", "skos:narrowMatch MetaCyc:RXN-19996", "skos:narrowMatch MetaCyc:RXN-19997", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25798\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/iss...

null

false

true

1

GO:0004664

4,664

prephenate dehydratase activity

molecular_function

Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2.

[ "EC:4.2.1.51" ]

null

[ "prephenate hydro-lyase (decarboxylating)", "prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)" ]

[ "RELATED", "RELATED" ]

[]

[ "EC:4.2.1.51", "MetaCyc:PREPHENATEDEHYDRAT-RXN", "RHEA:21648" ]

[ "GO:0016836" ]

[]

[ "GO:0016836" ]

[]

[ "skos:exactMatch EC:4.2.1.51", "skos:exactMatch RHEA:21648", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

4

GO:0004665

4,665

prephenate dehydrogenase (NADP+) activity

molecular_function

Catalysis of the reaction: NADP+ + prephenate = (4-hydroxyphenyl)pyruvate + CO2 + NADPH.

[ "EC:1.3.1.13", "RHEA:21640" ]

null

[ "prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity", "prephenate:NADP+ oxidoreductase (decarboxylating)" ]

[ "RELATED", "RELATED" ]

[]

[ "EC:1.3.1.13", "KEGG_REACTION:R01730", "MetaCyc:PREPHENATE-DEHYDROGENASE-NADP+-RXN", "RHEA:21640" ]

[ "GO:0016628" ]

[]

[ "GO:0016628" ]

[]

[ "skos:exactMatch EC:1.3.1.13", "skos:exactMatch RHEA:21640", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

8

GO:0004666

4,666

prostaglandin-endoperoxide synthase activity

molecular_function

Catalysis of the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2.

[ "RHEA:23728" ]

null

[ "(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity", "(PG)H synthase activity", "fatty acid cyclooxygenase activity", "PG synthetase activity", "prostaglandin endoperoxide synthetase activity", "prostaglandin G/H synthase activity", "prostaglandin synthase activit...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:1.14.99.1", "MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN", "Reactome:R-HSA-140355 \"Arachidonate is oxidised to PGG2 by PTGS1\"", "Reactome:R-HSA-2309787 \"Arachidonate is oxidised to PGG2 by PTGS2\"", "RHEA:23728" ]

[ "GO:0016705" ]

[]

[ "GO:0016705" ]

[]

[ "skos:exactMatch EC:1.14.99.1", "skos:exactMatch RHEA:23728", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

6

GO:0004667

4,667

prostaglandin-D synthase activity

molecular_function

Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2).

[ "EC:5.3.99.2", "RHEA:10600" ]

null

[ "(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity", "PGD2 synthase activity", "PGH-PGD isomerase activity", "prostaglandin D2 synthase activity", "prostaglandin-H2 D-isomerase activity", "prostaglandin-R-prostaglandin D isomerase activity" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:5.3.99.2", "KEGG_REACTION:R02266", "MetaCyc:PROSTAGLANDIN-D-SYNTHASE-RXN", "Reactome:R-HSA-2161620 \"PGH2 is isomerised to PGD2 by PTGDS\"", "Reactome:R-HSA-2161701 \"PGH2 is isomerised to PGD2 by HPGDS\"", "RHEA:10600" ]

[ "GO:0016860" ]

[]

[ "GO:0016860" ]

[]

[ "skos:exactMatch EC:5.3.99.2", "skos:exactMatch RHEA:10600", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

9

GO:0004668

4,668

protein-arginine deiminase activity

molecular_function

Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent.

[ "PMID:27393304" ]

null

[ "peptidylarginine deiminase activity", "protein-L-arginine iminohydrolase activity" ]

[ "RELATED", "RELATED" ]

[]

[ "EC:3.5.3.15", "MetaCyc:PROTEIN-ARGININE-DEIMINASE-RXN", "Reactome:R-HSA-1183128 \"PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins\"", "Reactome:R-HSA-3247569 \"PADI4 deiminates Histones\"", "RHEA:18089" ]

[ "GO:0016813" ]

[]

[ "GO:0016813" ]

[]

[ "skos:exactMatch EC:3.5.3.15", "skos:exactMatch RHEA:18089", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18666\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

3

GO:0004671

4,671

protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity

molecular_function

Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.

[ "EC:2.1.1.100" ]

null

[ "farnesyl cysteine C-terminal methyltransferase activity", "farnesyl-protein carboxymethyltransferase activity", "farnesylated protein C-terminal O-methyltransferase activity", "isoprenylated protein methyltransferase activity", "isoprenylcysteine carboxylmethyltransferase activity", "prenylated protein c...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED" ]

[ "GO:0018225" ]

[]

[ "EC:2.1.1.100", "KEGG_REACTION:R04496", "MetaCyc:2.1.1.100-RXN", "Reactome:R-HSA-6788650 \"ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins\"", "Reactome:R-HSA-9647977 \"ICMT methylates S-Farn RAS proteins\"", "RHEA:21672" ]

[ "GO:0003880", "GO:0008757" ]

[]

[ "GO:0003880", "GO:0008757" ]

[]

[ "skos:exactMatch EC:2.1.1.100", "skos:exactMatch RHEA:21672", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

4

GO:0004672

4,672

protein kinase activity

molecular_function

Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

[ "PMID:25399640" ]

Note that triphosphate is used as a phosphate donor by at least one kinase.

[ "protamine kinase activity" ]

[ "NARROW" ]

[ "GO:0050222" ]

[ "goslim_candida" ]

[ "Reactome:R-HSA-156832 \"INF-gamma induced phosphorylation of L13a\"", "Reactome:R-HSA-5693148 \"BCKDK phosphorylates BCKDH\"", "Reactome:R-HSA-937034 \"IRAK1 phosphorylates Pellino\"", "Reactome:R-HSA-9604606 \"Unknown kinase phosphorylates NICD4\"", "Reactome:R-HSA-9673284 \"GTP-bound RAC1 contributes to ...

[ "GO:0016301", "GO:0016773", "GO:0140096" ]

[]

[ "GO:0016301", "GO:0016773", "GO:0140096" ]

[]

null

false

true

2

GO:0004674

4,674

protein serine/threonine kinase activity

molecular_function

Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

[ "EC:2.7.11.-", "GOC:bf", "PMID:2956925" ]

null

[ "protein serine kinase activity", "protein serine-threonine kinase activity", "protein threonine kinase activity", "protein-serine kinase activity", "serine kinase activity", "serine protein kinase activity", "serine(threonine) protein kinase activity", "serine-specific protein kinase activity", "se...

[ "NARROW", "RELATED", "NARROW", "NARROW", "NARROW", "NARROW", "RELATED", "NARROW", "RELATED", "NARROW" ]

[ "GO:0004695", "GO:0004696", "GO:0004700", "GO:0106311" ]

[]

[ "EC:2.7.11.-", "EC:2.7.11.1", "EC:2.7.11.28", "EC:2.7.11.29", "EC:2.7.11.3", "EC:2.7.11.9", "MetaCyc:PROTEIN-KINASE-RXN", "Reactome:R-HSA-109702 \"PDPK1 phosphorylates AKT2\"", "Reactome:R-HSA-109822 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1\"", "Reactome:R-HSA-109823 \"MAPK3,(MAPK1) ...

[ "GO:0004672" ]

[]

[ "GO:0004672" ]

[]

[ "skos:exactMatch EC:2.7.11.-", "skos:exactMatch MetaCyc:PROTEIN-KINASE-RXN", "skos:narrowMatch EC:2.7.11.1", "skos:narrowMatch EC:2.7.11.28", "skos:narrowMatch EC:2.7.11.29", "skos:narrowMatch EC:2.7.11.3", "skos:narrowMatch EC:2.7.11.9", "term_tracker_item \"https://github.com/geneontology/go-ontolog...

null

false

true

7

GO:0004675

4,675

transmembrane receptor protein serine/threonine kinase activity

molecular_function

Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

[ "RHEA:18673" ]

null

[ "receptor protein serine/threonine kinase activity", "receptor serine/threonine protein kinase activity" ]

[ "RELATED", "RELATED" ]

[]

[ "EC:2.7.11.30", "MetaCyc:2.7.11.30-RXN", "Reactome:R-HSA-170868 \"Activated type I receptor phosphorylates SMAD2/3 directly\"", "Reactome:R-HSA-198732 \"STAT3 activation\"", "Reactome:R-HSA-201476 \"Activated type I receptor phosphorylates R-Smad1/5/8 directly\"", "RHEA:18673" ]

[ "GO:0004674", "GO:0019199" ]

[ "part_of GO:0007178" ]

[ "part_of" ]

[ "GO:0007178" ]

[ "GO:0004674", "GO:0007178", "GO:0019199" ]

[]

[ "skos:exactMatch EC:2.7.11.30", "skos:exactMatch RHEA:18673" ]

null

false

true

7

GO:0004676

4,676

3-phosphoinositide-dependent protein kinase activity

molecular_function

Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.

[ "GOC:mah" ]

This reaction requires the presence of a phosphatidylinositol-3-phosphate.

[ "PDK activity", "phosphatidylinositol-3-phosphate protein kinase activity" ]

[ "RELATED", "EXACT" ]

[]

[ "Reactome:R-HSA-437195 \"PDPK1 activates PRKCZ\"" ]

[ "GO:0004674" ]

[]

[ "GO:0004674" ]

[]

[ "skos:broadMatch EC:2.7.11.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]

null

false

true

2

GO:0004677

4,677

DNA-dependent protein kinase activity

molecular_function

DNA dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.

[ "GOC:mah" ]

This reaction requires the presence of DNA.

[]

[ "GO:0004674" ]

[]

[ "GO:0004674" ]

[]

[ "skos:broadMatch EC:2.7.11.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]

null

false

true

8

GO:0004679

4,679

AMP-activated protein kinase activity

molecular_function

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.

[ "GOC:mah" ]

null

[ "5'-AMP-activated protein kinase activity", "AMPK activity", "protein kinase A activity", "SNF1A/AMP-activated protein kinase activity" ]

[ "EXACT", "RELATED", "EXACT", "NARROW" ]

[]

[ "Reactome:R-HSA-1592244 \"AMPK phosphorylates PPARGC1A\"", "Reactome:R-HSA-163691 \"Phosphorylation of ChREBP at Serine 556 by AMPK\"", "Reactome:R-HSA-200423 \"pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis\"", "Reactome:R-HSA-380927 \"p-AMPK phosphorylates TSC1:TSC2\"", "Reactome:R-HSA-447074 \...

[ "GO:0004674" ]

[ "has_part GO:0016208" ]

[ "has_part" ]

[ "GO:0016208" ]

[ "GO:0004674", "GO:0016208" ]

[]

[ "skos:broadMatch EC:2.7.11.1" ]

null

false

true

7

GO:0004680

4,680

obsolete casein kinase activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it represents a gene product.

[ "casein kinase activity" ]

[ "EXACT" ]

[]

[ "GO:0004674" ]

[]

null

true

7

GO:0004681

4,681

obsolete casein kinase I activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it represents a gene product.

[ "casein kinase I activity" ]

[ "EXACT" ]

[]

[ "GO:0004674" ]

[]

null

true

2

GO:0004682

4,682

obsolete protein kinase CK2 activity

molecular_function

OBSOLETE. Catalysis of the reaction: casein + ATP = phosphocasein + ADP.

[ "EC:2.7.11.1" ]

This term was made obsolete because it represents a gene product.

[ "casein kinase II activity", "casein kinase II, catalytic activity", "protein kinase CK2 activity", "protein kinase CK2, intrinsic catalyst activity" ]

[ "RELATED", "EXACT", "EXACT", "EXACT" ]

[ "GO:0008604" ]

[]

[ "GO:0004674" ]

[]

null

true

6

GO:0004683

4,683

calcium/calmodulin-dependent protein kinase activity

molecular_function

Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. This activity require the presence of calcium-bound calmodulin.

[ "GOC:mah", "PMID:11264466" ]

null

[ "ATP:caldesmon O-phosphotransferase activity", "ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity", "Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity", "Ca2+/calmodulin-dependent protein kinase 1 activity", "Ca2+/calmodulin-dependent protein kinase activity", "C...

[ "NARROW", "RELATED", "NARROW", "NARROW", "RELATED", "NARROW", "NARROW", "NARROW", "NARROW", "EXACT", "EXACT", "NARROW", "NARROW", "EXACT", "NARROW", "EXACT", "NARROW", "RELATED", "NARROW", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", ...

[ "GO:0004684", "GO:0004685", "GO:0004688" ]

[]

[ "EC:2.7.11.17", "Reactome:R-HSA-111912 \"CaMK4 phosphorylates CREB1\"", "Reactome:R-HSA-111915 \"CAMK4 autophosphorylates\"", "Reactome:R-HSA-416320 \"Trafficking of GluR1-containing AMPA receptors\"", "Reactome:R-HSA-442749 \"CaMKK autophosphorylates in the nucleus\"", "Reactome:R-HSA-9006992 \"MECP2 is...

[ "GO:0004674" ]

[]

[ "GO:0004674" ]

[]

[ "skos:exactMatch EC:2.7.11.17", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

8

GO:0004686

4,686

elongation factor-2 kinase activity

molecular_function

Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate.

[ "EC:2.7.11.20", "MetaCyc:2.7.11.20-RXN" ]

null

[ "ATP:elongation factor 2 phosphotransferase activity", "Ca/CaM-kinase III activity", "calmodulin-dependent protein kinase III activity", "CaM kinase III activity", "eEF-2 kinase activity", "eEF2 kinase activity", "eEF2K", "EF2K", "elongation factor 2 kinase activity", "eukaryotic elongation factor...

[ "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.7.11.20", "MetaCyc:2.7.11.20-RXN", "RHEA:21436" ]

[ "GO:0004683" ]

[]

[ "GO:0004683" ]

[]

[ "skos:exactMatch EC:2.7.11.20", "skos:exactMatch RHEA:21436", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30980\" xsd:anyURI" ]

null

false

true

6

GO:0004689

4,689

phosphorylase kinase activity

molecular_function

Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a.

[ "EC:2.7.11.19" ]

null

[ "ATP:phosphorylase-b phosphotransferase activity", "dephosphophosphorylase kinase activity", "glycogen phosphorylase kinase activity", "PHK", "phosphorylase B kinase activity", "phosphorylase kinase (phosphorylating) activity", "phosphorylase kinase, intrinsic catalyst activity", "STK17" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED" ]

[ "GO:0008606" ]

[]

[ "EC:2.7.11.19", "MetaCyc:2.7.11.19-RXN", "Reactome:R-HSA-453337 \"glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP\"", "Reactome:R-HSA-71541 \"glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP\"", "Reactome:R-HSA-7158...

[ "GO:0004683" ]

[]

[ "GO:0004683" ]

[]

[ "skos:exactMatch EC:2.7.11.19", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

2

GO:0004690

4,690

cyclic nucleotide-dependent protein kinase activity

molecular_function

cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.

[ "GOC:mah" ]

This reaction requires the presence of a cyclic nucleotide.

[]

[ "GO:0004674" ]

[ "has_part GO:0030551" ]

[ "has_part" ]

[ "GO:0030551" ]

[ "GO:0004674", "GO:0030551" ]

[]

null

false

true

4

GO:0004691

4,691

cAMP-dependent protein kinase activity

molecular_function

cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.

[ "PMID:32935175", "PMID:35053423", "PMID:35805104" ]

This reaction requires the presence of cAMP.

[ "3',5' cAMP-dependent protein kinase activity", "3',5'-cAMP-dependent protein kinase activity", "adenosine 3',5'-cyclophosphate-dependent protein kinase activity", "AMPK", "ATP:protein phosphotransferase (cAMP-dependent) activity", "cAMP-dependent protein kinase, intrinsic catalyst activity", "cyclic AM...

[ "EXACT", "EXACT", "EXACT", "RELATED", "RELATED", "EXACT", "EXACT", "RELATED", "RELATED", "BROAD", "RELATED" ]

[ "GO:0008602" ]

[]

[ "EC:2.7.11.11", "Reactome:R-HSA-163672 \"Phosphorylation of ChREBP at Thr(653) by PKA\"", "Reactome:R-HSA-163676 \"Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA\"", "Reactome:R-HSA-163773 \"PKA tetramer:cAMP phosphorylates PF2K-Pase\"", "Reactome:R-HSA-177275 \"PKA phosphorylates DARPP-32 on Thr34...

[ "GO:0004690" ]

[ "has_part GO:0030552" ]

[ "has_part" ]

[ "GO:0030552" ]

[ "GO:0004690", "GO:0030552" ]

[]

[ "skos:exactMatch EC:2.7.11.11" ]

null

false

true

9

GO:0004692

4,692

cGMP-dependent protein kinase activity

molecular_function

cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.

[ "GOC:mah" ]

This reaction requires the presence of cGMP.

[ "3':5'-cyclic GMP-dependent protein kinase activity", "ATP:protein phosphotransferase (cGMP-dependent) activity", "cGMP-dependent protein kinase ibeta activity", "guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity", "PKG", "PKG 1alpha", "PKG 1beta", "PKG II", "STK23" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.7.11.12", "Reactome:R-HSA-1475422 \"PTPS is phosphorylated by cGMP-dependant protein kinase II\"", "Reactome:R-HSA-1497853 \"Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II\"", "Reactome:R-HSA-418442 \"PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated ...

[ "GO:0004690" ]

[ "has_part GO:0030553" ]

[ "has_part" ]

[ "GO:0030553" ]

[ "GO:0004690", "GO:0030553" ]

[]

[ "skos:exactMatch EC:2.7.11.12", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

8

GO:0004693

4,693

cyclin-dependent protein serine/threonine kinase activity

molecular_function

Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

[ "GOC:pr", "GOC:rn", "PMID:7877684", "PMID:9841670" ]

This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).

[ "ATP:cyclin phosphotransferase activity", "cdc2 kinase activity", "CDK", "CDK activity", "CDK, catalytic subunit activity", "cdk-activating kinase activity", "Cdk-activating protein kinase activity", "cyclin D-cdk6 kinase activity", "cyclin D-dependent kinase activity", "cyclin E kinase activity",...

[ "RELATED", "NARROW", "RELATED", "EXACT", "EXACT", "RELATED", "RELATED", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "BROAD", "NARROW", "NARROW", "BROAD", "EXACT", "NARROW", "NARROW" ]

[ "GO:0016537" ]

[]

[ "EC:2.7.11.22", "Reactome:R-HSA-1226094 \"Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex\"", "Reactome:R-HSA-1226095 \"Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1...

[ "GO:0004674", "GO:0097472" ]

[]

[ "GO:0004674", "GO:0097472" ]

[]

[ "skos:exactMatch EC:2.7.11.22", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

5

GO:0004694

4,694

eukaryotic translation initiation factor 2alpha kinase activity

molecular_function

Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate.

[ "GOC:mah", "InterPro:IPR015516" ]

null

[]

[ "GO:0004674" ]

[ "part_of GO:0010998" ]

[ "part_of" ]

[ "GO:0010998" ]

[ "GO:0004674", "GO:0010998" ]

[]

[ "skos:broadMatch EC:2.7.11.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]

null

false

true

1

GO:0004697

4,697

diacylglycerol-dependent serine/threonine kinase activity

molecular_function

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.

[ "EC:2.7.11.13" ]

null

[ "ATP:protein phosphotransferase (diacylglycerol-dependent) activity", "cPKC", "cPKCalpha", "cPKCbeta", "cPKCgamma", "diacylglycerol-activated phospholipid-dependent PKC activity", "diacylglycerol-activated phospholipid-dependent protein kinase C activity", "nPKC", "nPKCdelta", "nPKCepsilon", "nP...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "NARROW", "RELATED" ]

[ "GO:0004701" ]

[]

[ "EC:2.7.11.13", "Reactome:R-HSA-5218805 \"PKC autophosphorylates\"", "Reactome:R-HSA-751040 \"PKC phosphorylates G alpha (z)\"", "Reactome:R-HSA-9626817 \"PKC phosphorylates NCF1\"" ]

[ "GO:0004674" ]

[]

[ "GO:0004674" ]

[]

[ "skos:exactMatch EC:2.7.11.13", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25457\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

4

GO:0004698

4,698

calcium,diacylglycerol-dependent serine/threonine kinase activity

molecular_function

Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction is activated in the presence of diacylglycerol and calcium.

[ "PMID:34834162" ]

null

[ "calcium-dependent PKC activity", "conventional protein kinase C activity" ]

[ "EXACT", "EXACT" ]

[]

[ "Reactome:R-HSA-114683 \"Phosphorylation of Platelet Sec-1\"", "Reactome:R-HSA-114684 \"Phosphorylation of Syntaxin-4\"", "Reactome:R-HSA-1433508 \"PKC alpha interacts with and phosphorylates KIT\"", "Reactome:R-HSA-2179413 \"Activated PKC-alpha activate MMP3\"", "Reactome:R-HSA-416639 \"Trafficking of Glu...

[ "GO:0004697", "GO:0009931" ]

[]

[ "GO:0004697", "GO:0009931" ]

[]

[ "skos:broadMatch EC:2.7.11.13", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25457\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]

null

false

true

9

GO:0004699

4,699

diacylglycerol-dependent, calcium-independent serine/threonine kinase activity

molecular_function

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction is activated by diacylglycerol but not by calcium.

[ "PMID:34834162" ]

null

[ "atypical protein kinase C activity", "calcium-independent PKC activity", "novel protein kinase C activity" ]

[ "RELATED", "EXACT", "EXACT" ]

[]

[ "Reactome:R-HSA-198314 \"DAG stimulates protein kinase C-delta\"", "Reactome:R-HSA-2730863 \"Phosphorylation of CARMA1 by PKC-theta\"", "Reactome:R-HSA-374664 \"Phosphorylation and activation of Ezrin\"", "Reactome:R-HSA-429698 \"PRKD1,2,3 phosphorylates CERT1-2\"", "Reactome:R-HSA-450533 \"PKCdelta phospho...

[ "GO:0004697" ]

[]

[ "GO:0004697" ]

[]

[ "skos:broadMatch EC:2.7.11.13", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25457\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]

null

false

true

5

GO:0004702

4,702

obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity

molecular_function

OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

[ "GOC:bf", "GOC:mah" ]

This term was obsoleted because it was not clearly defined.

[ "receptor signaling protein serine/threonine kinase activity", "receptor signalling protein serine/threonine kinase activity" ]

[ "EXACT", "EXACT" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14232\" xsd:anyURI" ]

null

true

9

GO:0004703

4,703

G protein-coupled receptor kinase activity

molecular_function

Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate.

[ "GOC:dph" ]

null

[ "ATP:G-protein-coupled receptor phosphotransferase activity", "G protein coupled receptor phosphorylating protein kinase activity", "G-protein coupled receptor kinase activity", "G-protein-coupled receptor phosphorylating protein kinase activity", "GPCR kinase activity", "GPCR phosphorylating protein kina...

[ "RELATED", "EXACT", "RELATED", "EXACT", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[ "GO:0004678" ]

[]

[ "EC:2.7.11.16", "RHEA:12008" ]

[ "GO:0004674" ]

[]

[ "GO:0004674" ]

[]

[ "skos:exactMatch EC:2.7.11.16", "skos:exactMatch RHEA:12008", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

8

GO:0004704

4,704

obsolete NF-kappaB-inducing kinase activity

molecular_function

OBSOLETE. Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK).

[ "PMID:20685151" ]

This terms was obsoleted because it represents a specific gene product and it was instantiated as an enzyme regulator, but it is actually a protein kinase)This

[ "NIK" ]

[ "EXACT" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24418\" xsd:anyURI" ]

null

true

4

GO:0004705

4,705

JUN kinase activity

molecular_function

Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors.

[ "GOC:bf", "ISBN:0198506732" ]

null

[ "c-Jun N-terminal kinase activity", "JNK", "JNK3alpha1", "SAPK1" ]

[ "NARROW", "EXACT", "RELATED", "NARROW" ]

[]

[ "Reactome:R-HSA-168136 \"Activated JNKs phosphorylate c-JUN\"", "Reactome:R-HSA-204949 \"NRIF and TRAF6 may activate JNK\"", "Reactome:R-HSA-205075 \"JNK phosphorylates BIM, BAD and other targets\"", "Reactome:R-HSA-205132 \"NRAGE activates JNK\"", "Reactome:R-HSA-9673789 \"Activated JNK phosphorylates c-JU...

[ "GO:0004707" ]

[ "part_of GO:0007254" ]

[ "part_of" ]

[ "GO:0007254" ]

[ "GO:0004707", "GO:0007254" ]

[]

[ "skos:broadMatch EC:2.7.11.24", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]

null

false

true

2

GO:0004706

4,706

JUN kinase kinase kinase activity

molecular_function

Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).

[ "GOC:bf" ]

null

[ "JNK kinase kinase activity", "JNKKK" ]

[ "RELATED", "EXACT" ]

[]

[ "GO:0004709" ]

[]

[ "GO:0004709" ]

[]

[ "skos:broadMatch EC:2.7.11.25", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]

null

false

true

8

GO:0004707

4,707

MAP kinase activity

molecular_function

Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation...

[ "GOC:ma", "ISBN:0198547684" ]

null

[ "ATP:protein phosphotransferase (MAPKK-activated) activity", "ERK", "ERK1", "ERK2", "extracellular signal-regulated kinase activity", "MAP kinase 1 activity", "MAP kinase 2 activity", "MAPK", "MBP kinase I activity", "MBP kinase II activity", "mitogen activated kinase activity", "mitogen-activ...

[ "RELATED", "RELATED", "EXACT", "RELATED", "NARROW", "NARROW", "NARROW", "RELATED", "NARROW", "NARROW", "EXACT", "RELATED", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW" ]

[ "GO:0008338", "GO:0008339", "GO:0016908", "GO:0016909" ]

[]

[ "EC:2.7.11.24", "KEGG_REACTION:R00162", "MetaCyc:2.7.11.24-RXN", "Reactome:R-HSA-111898 \"Phosphorylation of cPLA2 by ERK-2\"", "Reactome:R-HSA-198733 \"ERK5 is activated\"", "Reactome:R-HSA-445079 \"Phosphorylation of L1 by ERK\"", "Reactome:R-HSA-5654560 \"Activated ERK1/2 threonine-phosphorylates FGF...

[ "GO:0004674" ]

[ "part_of GO:0000165" ]

[ "part_of" ]

[ "GO:0000165" ]

[ "GO:0000165", "GO:0004674" ]

[]

[ "skos:exactMatch EC:2.7.11.24", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

8

GO:0004708

4,708

MAP kinase kinase activity

molecular_function

Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a T-X-Y motif in the activation loop of a MAP kinase (MAPK) substrate.

[ "PMID:12623839", "PMID:38270553" ]

null

[ "ATP:protein phosphotransferase (MAPKKK-activated) activity", "ERK activator kinase activity", "MAP kinase kinase 4 activity", "MAP kinase kinase 7 activity", "MAP kinase or ERK kinase activity", "MAP2K", "MAPK activator activity", "MAPKK", "MAPKK activity", "MAPKK1", "MEK activity", "MEK1", ...

[ "RELATED", "EXACT", "NARROW", "NARROW", "RELATED", "RELATED", "EXACT", "RELATED", "EXACT", "RELATED", "BROAD", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.7.12.2", "MetaCyc:2.7.12.2-RXN", "Reactome:R-HSA-1247960 \"Activation of p38 MAPK\"", "Reactome:R-HSA-3238999 \"Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5\"", "Reactome:R-HSA-448951 \"Activation of p38 alpha/beta MAPK\"", "Reactome:R-HSA-450333 \"Activated human MKK3/M...

[ "GO:0004712" ]

[ "part_of GO:0000165" ]

[ "part_of" ]

[ "GO:0000165" ]

[ "GO:0000165", "GO:0004712" ]

[]

[ "skos:exactMatch EC:2.7.12.2", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27856\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

8

GO:0004709

4,709

MAP kinase kinase kinase activity

molecular_function

Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.

[ "PMID:9561267" ]

null

[ "ATP:protein phosphotransferase (MAPKKKK-activated) activity", "cMos", "cRaf", "MAP3K", "MAPK/ERK kinase kinase activity", "MAPKKK activity", "MEK kinase activity", "MEKK", "MEKK activity", "MEKK1", "MEKK2", "MEKK3", "Mil/Raf", "mitogen-activated protein kinase kinase kinase activity", "...

[ "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "NARROW", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[ "GO:0004710" ]

[]

[ "EC:2.7.11.25", "MetaCyc:2.7.11.25-RXN", "Reactome:R-HSA-2730887 \"Autophosphorylation and activation of MEKK1\"", "Reactome:R-HSA-392530 \"p-S400-Cot phosphorylates NIK\"", "Reactome:R-HSA-451649 \"TPL2 phosphorylates MEK1, SEK1\"", "Reactome:R-HSA-727819 \"TAK1 phosphorylates MKK6\"", "Reactome:R-HSA-...

[ "GO:0004674" ]

[ "part_of GO:0000165" ]

[ "part_of" ]

[ "GO:0000165" ]

[ "GO:0000165", "GO:0004674" ]

[]

[ "skos:exactMatch EC:2.7.11.25", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

1

GO:0004711

4,711

ribosomal protein S6 kinase activity

molecular_function

Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.

[ "GOC:mah", "PMID:9822608" ]

null

[]

[ "GO:0004674" ]

[]

[ "GO:0004674" ]

[]

[ "skos:broadMatch EC:2.7.11.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]

null

false

true

5

GO:0004712

4,712

protein serine/threonine/tyrosine kinase activity

molecular_function

Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

[ "GOC:mah" ]

null

[ "dual-specificity kinase activity", "dual-specificity protein kinase", "protein threonine/tyrosine kinase activity" ]

[ "EXACT", "EXACT", "NARROW" ]

[]

[ "EC:2.7.12.1", "Reactome:R-HSA-5672969 \"Phosphorylation of RAF\"", "Reactome:R-HSA-5674373 \"MAP2Ks phosphorylate MAPK at the Golgi membrane\"", "Reactome:R-HSA-6802910 \"Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants\"", "Reactome:R-HSA-6802916 \"RAF is phosphorylated...

[ "GO:0004672" ]

[]

[ "GO:0004672" ]

[]

[ "skos:exactMatch EC:2.7.12.1" ]

null

false

true

7

GO:0004713

4,713

protein tyrosine kinase activity

molecular_function

Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

[ "RHEA:10596" ]

null

[ "protein-tyrosine kinase activity" ]

[ "EXACT" ]

[ "GO:0004718" ]

[]

[ "EC:2.7.10.-", "MetaCyc:2.7.10.1-RXN", "Reactome:R-HSA-112333 \"SRC autophosphorylation is positively regulated by InlA-bound CDH1\"", "Reactome:R-HSA-114600 \"Fyn/Lyn-mediated phosphorylation of FcR1 gamma\"", "Reactome:R-HSA-1168394 \"STAT5 tyrosine phosphorylation\"", "Reactome:R-HSA-1169421 \"Trans-au...

[ "GO:0004672" ]

[]

[ "GO:0004672" ]

[]

[ "skos:exactMatch EC:2.7.10.-", "skos:exactMatch RHEA:10596" ]

null

false

true

9