go_id string | go_numeric_id int64 | name string | namespace string | definition string | definition_xrefs list | comment string | synonyms list | synonym_scopes list | alt_ids list | subsets list | xrefs list | is_a_ids list | relationship_edges list | relationship_types list | relationship_target_ids list | parent_ids list | intersection_of list | union_of list | disjoint_from list | replaced_by list | consider list | property_values list | created_by string | creation_date string | is_obsolete bool | in_go_basic bool | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GO:0004714 | 4,714 | transmembrane receptor protein tyrosine kinase activity | molecular_function | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. | [
"EC:2.7.10.1",
"GOC:mah"
] | null | [
"receptor protein tyrosine kinase activity",
"receptor protein-tyrosine kinase activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.10.1",
"Reactome:R-HSA-166544 \"TrkA receptor autophosphorylates\"",
"Reactome:R-HSA-167019 \"SHC, complexed with TrkA, is tyrosine-phosphorylated\"",
"Reactome:R-HSA-167683 \"TrkA phosphorylates PLCG1\"",
"Reactome:R-HSA-169905 \"ARMS is phosphorylated by active TrkA receptor\"",
"Reactome:R-HSA-... | [
"GO:0004713",
"GO:0019199"
] | [] | [] | [] | [
"GO:0004713",
"GO:0019199"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.10.1",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28176\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004715 | 4,715 | non-membrane spanning protein tyrosine kinase activity | molecular_function | Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. | [
"EC:2.7.10.2"
] | null | [
"ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity",
"ATP:protein-tyrosine O-phosphotransferase activity",
"Bruton's tyrosine kinase activity",
"cytoplasmic protein tyrosine kinase activity",
"focal adhesion kinase activity",
"janus kinase 1 activity",
"janus kinase 2 activity",
"jan... | [
"RELATED",
"BROAD",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"RELATED",
"NARROW"
] | [] | [] | [
"EC:2.7.10.2",
"Reactome:R-HSA-1112602 \"Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor\"",
"Reactome:R-HSA-1112703 \"PTPN11 is phosphorylated\"",
"Reactome:R-HSA-1168423 \"JAK2 phosphorylation of IRS-1/2\"",
"Reactome:R-HSA-1168459 \"Lyn activates ERK\"",
"Reactome:R-HSA-1168767 \"JAK2 phosphor... | [
"GO:0004713"
] | [] | [] | [] | [
"GO:0004713"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.10.2",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28176\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004716 | 4,716 | obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity | molecular_function | OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. | [
"GOC:curators"
] | This term was obsoleted because it was not clearly defined. | [
"receptor signaling protein tyrosine kinase activity",
"receptor signalling protein tyrosine kinase activity"
] | [
"EXACT",
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14232\" xsd:anyURI"
] | null | null | true | true | 7 |
GO:0004717 | 4,717 | obsolete focal adhesion kinase activity | molecular_function | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:jid"
] | This term was made obsolete because it represents a gene product, and because the gene was named after its location of action rather than after its molecular function. | [
"FAK",
"focal adhesion kinase activity"
] | [
"EXACT",
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004713"
] | [] | [] | null | null | true | true | 8 |
GO:0004719 | 4,719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity | molecular_function | Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. | [
"EC:2.1.1.77"
] | null | [
"D-aspartyl/L-isoaspartyl methyltransferase activity",
"L-aspartyl/L-isoaspartyl protein methyltransferase activity",
"L-isoaspartyl protein carboxyl methyltransferase activity",
"L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity",
"protein (D-aspartate) methyltransferase activity",
"pr... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.1.1.77",
"MetaCyc:2.1.1.77-RXN",
"Reactome:R-HSA-5676966 \"PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp\"",
"RHEA:12705"
] | [
"GO:0008757",
"GO:0051998"
] | [] | [] | [] | [
"GO:0008757",
"GO:0051998"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.1.1.77",
"skos:exactMatch RHEA:12705",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004720 | 4,720 | protein-lysine 6-oxidase activity | molecular_function | Catalysis of the reaction: L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4+. | [
"RHEA:24544"
] | null | [
"lysyl oxidase activity",
"protein-L-lysine:oxygen 6-oxidoreductase (deaminating)"
] | [
"RELATED",
"RELATED"
] | [
"GO:0018056"
] | [] | [
"EC:1.4.3.13",
"MetaCyc:PROTEIN-LYSINE-6-OXIDASE-RXN",
"Reactome:R-HSA-2002466 \"Formation of allysine by LOX\"",
"Reactome:R-HSA-2129375 \"Elastin cross-linking by lysyl oxidase\"",
"Reactome:R-HSA-2395340 \"Formation of hydroxyallysine by LOX\"",
"RHEA:24544"
] | [
"GO:0052597",
"GO:0140096"
] | [] | [] | [] | [
"GO:0052597",
"GO:0140096"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.4.3.13",
"skos:exactMatch RHEA:24544",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004721 | 4,721 | phosphoprotein phosphatase activity | molecular_function | Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. | [
"ISBN:0198547684"
] | null | [
"phosphoprotein phosphohydrolase activity",
"protein phosphatase activity",
"protein phosphatase-1 activity",
"protein phosphatase-2A activity",
"protein phosphatase-2B activity",
"protein phosphatase-2C activity"
] | [
"EXACT",
"EXACT",
"NARROW",
"NARROW",
"NARROW",
"NARROW"
] | [] | [] | [
"EC:3.1.3.55",
"Reactome:R-HSA-112383 \"Hypophosphorylation of RNA Pol II CTD by FCP1P protein\"",
"Reactome:R-HSA-113503 \"PP2A mediated localization of RB1 protein in chromatin\"",
"Reactome:R-HSA-1363274 \"Dephosphorylation of p107 (RBL1) by PP2A\"",
"Reactome:R-HSA-1363276 \"Dephosphorylation of p130 (R... | [
"GO:0016791",
"GO:0140096"
] | [] | [] | [] | [
"GO:0016791",
"GO:0140096"
] | [] | [] | [] | [] | [] | [
"skos:narrowMatch EC:3.1.3.55",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25787\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004722 | 4,722 | protein serine/threonine phosphatase activity | molecular_function | Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. | [
"GOC:bf"
] | null | [
"magnesium-dependent protein serine/threonine phosphatase activity",
"phosphatase I",
"phosphatase II",
"phosphatase III",
"protein phosphatase type 1 activity",
"protein phosphatase type 2A activity",
"protein phosphatase type 2B activity",
"protein phosphatase type 2C activity",
"protein phosphata... | [
"RELATED",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"EXACT"
] | [
"GO:0000158",
"GO:0000163",
"GO:0004724",
"GO:0008598",
"GO:0008600",
"GO:0015071",
"GO:0030357",
"GO:0030358",
"GO:0030360",
"GO:0030361",
"GO:0106306",
"GO:0106307"
] | [] | [
"EC:3.1.3.16",
"MetaCyc:3.1.3.16-RXN",
"Reactome:R-HSA-1295632 \"PPA2A dephosphorylates SPRY2\"",
"Reactome:R-HSA-163568 \"phosphorylated perilipin + H2O -> perilipin + orthophosphate\"",
"Reactome:R-HSA-163689 \"PP2A complex dephosphorylates pChREBP (MLXIPL)\"",
"Reactome:R-HSA-163750 \"PP2A complex deph... | [
"GO:0004721"
] | [] | [] | [] | [
"GO:0004721"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.3.16",
"skos:narrowMatch RHEA:20629",
"skos:narrowMatch RHEA:47004",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22458\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25787\" xsd:anyURI",
"term_tracker_item \"https:... | null | null | false | true | 4 |
GO:0004723 | 4,723 | calcium-dependent protein serine/threonine phosphatase activity | molecular_function | Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions. | [
"GOC:mah"
] | null | [
"calcineurin",
"calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity"
] | [
"NARROW",
"EXACT"
] | [
"GO:0008596"
] | [] | [
"Reactome:R-HSA-2025882 \"Calcineurin dephosphorylates NFATC1,2,3\""
] | [
"GO:0004722"
] | [] | [] | [] | [
"GO:0004722"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 9 |
GO:0004726 | 4,726 | non-membrane spanning protein tyrosine phosphatase activity | molecular_function | Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. | [
"PMID:34353440"
] | null | [] | [] | [] | [] | [
"Reactome:R-HSA-177923 \"Sustained activation of SRC kinase by SHP2\"",
"Reactome:R-HSA-177924 \"Dephosphorylation of Gab1 by SHP2\"",
"Reactome:R-HSA-177926 \"Dephosphorylation of PAG by SHP2\"",
"Reactome:R-HSA-177935 \"SHP2 dephosphorylates Tyr 992 on EGFR\"",
"Reactome:R-HSA-9635739 \"PTPN7 dephosphoryl... | [
"GO:0004725"
] | [] | [] | [] | [
"GO:0004725"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:3.1.3.48",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28324\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004727 | 4,727 | obsolete prenylated protein tyrosine phosphatase activity | molecular_function | OBSOLETE. Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate. | [
"GOC:curators"
] | This term was obsoleted because it represents a specific substrate of protein tyrosine phosphatase activity ; GO:0004725. | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004725"
] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28382\" xsd:anyURI"
] | null | null | true | true | 5 |
GO:0004728 | 4,728 | obsolete signal transducer, downstream of receptor, with protein tyrosine phosphatase activity | molecular_function | OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. | [
"EC:3.1.3.48"
] | This term was obsoleted because it was not clearly defined. | [
"receptor signaling protein tyrosine phosphatase activity",
"receptor signalling protein tyrosine phosphatase activity"
] | [
"EXACT",
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14232\" xsd:anyURI"
] | null | null | true | true | 2 |
GO:0004729 | 4,729 | oxygen-dependent protoporphyrinogen oxidase activity | molecular_function | Catalysis of the reaction: 3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX. | [
"RHEA:25576"
] | null | [
"protoporphyrinogen-IX:oxygen oxidoreductase activity"
] | [
"RELATED"
] | [] | [] | [
"EC:1.3.3.4",
"KEGG_REACTION:R03222",
"MetaCyc:PROTOPORGENOXI-RXN",
"Reactome:R-HSA-189423 \"PPO oxidises PPGEN9 to PRIN9\"",
"RHEA:25576"
] | [
"GO:0016634",
"GO:0070818"
] | [] | [] | [] | [
"GO:0016634",
"GO:0070818"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.3.3.4",
"skos:exactMatch KEGG_REACTION:R03222",
"skos:exactMatch MetaCyc:PROTOPORGENOXI-RXN",
"skos:exactMatch RHEA:25576",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28776\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004731 | 4,731 | purine-nucleoside phosphorylase activity | molecular_function | Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. | [
"EC:2.4.2.1"
] | null | [
"inosine phosphorylase activity",
"inosine-guanosine phosphorylase activity",
"PNPase activity",
"PUNPI",
"PUNPII",
"purine deoxynucleoside phosphorylase activity",
"purine deoxyribonucleoside phosphorylase activity",
"purine nucleoside phosphorylase activity",
"purine ribonucleoside phosphorylase a... | [
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.2.1",
"MetaCyc:PNP-RXN",
"Reactome:R-HSA-112033 \"PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine\"",
"Reactome:R-HSA-112034 \"PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine\"",
"Reactome:R-HSA-74242 \"PNP catalyzes the conversion of (d... | [
"GO:0016763"
] | [] | [] | [] | [
"GO:0016763"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.2.1",
"skos:exactMatch RHEA:19805",
"skos:narrowMatch RHEA:27638",
"skos:narrowMatch RHEA:27642",
"skos:narrowMatch RHEA:27646",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004732 | 4,732 | pyridoxal oxidase activity | molecular_function | Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + H+ + H2O2. | [
"RHEA:23724"
] | null | [
"pyridoxal:oxygen 4-oxidoreductase activity"
] | [
"RELATED"
] | [] | [] | [
"EC:1.2.3.8",
"MetaCyc:PYRIDOXAL-OXIDASE-RXN",
"RHEA:23724"
] | [
"GO:0004031"
] | [] | [] | [] | [
"GO:0004031"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.2.3.8",
"skos:exactMatch RHEA:23724",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24731\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004734 | 4,734 | pyrimidodiazepine synthase activity | molecular_function | Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione. | [
"EC:1.5.4.1"
] | null | [
"PDA synthase activity",
"pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.5.4.1",
"MetaCyc:1.5.4.1-RXN",
"RHEA:10720"
] | [
"GO:0016648"
] | [] | [] | [] | [
"GO:0016648"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.5.4.1",
"skos:exactMatch RHEA:10720",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004735 | 4,735 | pyrroline-5-carboxylate reductase activity | molecular_function | Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. | [
"EC:1.5.1.2"
] | null | [
"1-pyrroline-5-carboxylate reductase activity",
"L-proline oxidase activity",
"L-proline-NAD(P)+ 5-oxidoreductase activity",
"L-proline:NAD(P)+ 5-oxidoreductase activity",
"NADPH-L-delta1-pyrroline carboxylic acid reductase activity",
"P5CR activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.5.1.2",
"MetaCyc:PYRROLINECARBREDUCT-RXN",
"Reactome:R-HSA-6783939 \"PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro\"",
"Reactome:R-HSA-6783955 \"PYCR3 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro\"",
"Reactome:R-HSA-70664 \"PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate t... | [
"GO:0016646"
] | [] | [] | [] | [
"GO:0016646"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.5.1.2",
"skos:exactMatch RHEA:14109",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004736 | 4,736 | pyruvate carboxylase activity | molecular_function | Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H+ + oxaloacetate + phosphate. | [
"EC:6.4.1.1",
"RHEA:20844"
] | null | [
"pyruvate:carbon-dioxide ligase (ADP-forming)",
"pyruvic carboxylase activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.4.1.1",
"KEGG_REACTION:R00344",
"MetaCyc:PYRUVATE-CARBOXYLASE-RXN",
"Reactome:R-HSA-70501 \"PC carboxylates PYR to OA\"",
"RHEA:20844"
] | [
"GO:0016885"
] | [] | [] | [] | [
"GO:0016885"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.4.1.1",
"skos:exactMatch RHEA:20844",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004737 | 4,737 | pyruvate decarboxylase activity | molecular_function | Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2. | [
"EC:4.1.1.1"
] | null | [
"2-oxo-acid carboxy-lyase (aldehyde-forming)",
"2-oxo-acid carboxy-lyase activity",
"alpha-carboxylase activity",
"alpha-ketoacid carboxylase activity",
"pyruvic decarboxylase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.1.1.1",
"MetaCyc:PYRUVATE-DECARBOXYLASE-RXN",
"RHEA:11628",
"RHEA:45484",
"RHEA:50312",
"RHEA:54356",
"RHEA:54360",
"RHEA:55072"
] | [
"GO:0016831"
] | [] | [] | [] | [
"GO:0016831"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.1.1",
"skos:exactMatch RHEA:11628",
"skos:narrowMatch RHEA:45484",
"skos:narrowMatch RHEA:50312",
"skos:narrowMatch RHEA:54356",
"skos:narrowMatch RHEA:54360",
"skos:narrowMatch RHEA:55072",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:any... | null | null | false | true | 2 |
GO:0004738 | 4,738 | obsolete pyruvate dehydrogenase activity | molecular_function | OBSOLETE. Catalysis of the oxidative decarboxylation of pyruvate. | [
"ISBN:0716720094"
] | This term was obsoleted because it is an unnecessary grouping term. | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24350\" xsd:anyURI"
] | null | null | true | true | 5 |
GO:0004739 | 4,739 | pyruvate dehydrogenase (acetyl-transferring) activity | molecular_function | Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H+ = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2. | [
"RHEA:19189"
] | null | [
"MtPDC (mitochondrial pyruvate dehydogenase complex) activity",
"PDH",
"pyruvate dehydrogenase (lipoamide) activity",
"pyruvate dehydrogenase complex activity",
"pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)",
"pyruvate:lipoami... | [
"NARROW",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.2.4.1",
"MetaCyc:RXN0-1134",
"Reactome:R-HSA-9861734 \"PDH E1 decarboxylates PYR, transferring acetyl to DLAT\"",
"RHEA:19189"
] | [
"GO:0016624"
] | [] | [] | [] | [
"GO:0016624"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:1.2.1.104",
"skos:broadMatch RHEA:28042",
"skos:exactMatch EC:1.2.4.1",
"skos:exactMatch RHEA:19189",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24350\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004741 | 4,741 | [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity | molecular_function | Catalysis of the reaction: O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + H2O = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate. | [
"EC:3.1.3.43"
] | null | [
"[pyruvate dehydrogenase (lipoamide)] phosphatase activity",
"[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity",
"pyruvate dehydrogenase (lipoamide) phosphatase activity"
] | [
"EXACT",
"EXACT",
"EXACT"
] | [
"GO:0019906"
] | [] | [
"EC:3.1.3.43",
"MetaCyc:3.1.3.43-RXN",
"Reactome:R-HSA-204169 \"PDP1,2 dephosphorylate p-lipo-PDH\"",
"RHEA:12669"
] | [
"GO:0004722"
] | [] | [] | [] | [
"GO:0004722"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.3.43",
"skos:exactMatch RHEA:12669",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26194\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004742 | 4,742 | dihydrolipoyllysine-residue acetyltransferase activity | molecular_function | Catalysis of the reaction: N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA. | [
"RHEA:17017"
] | The only observed direction catalyzed by this activity is that where the acetyl group is passed to coenzyme A - that is, the right-to-left direction of that shown in the definition. | [
"acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity",
"acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity",
"acetyl-CoA:dihydrolipoamide S-acetyltransferase activity",
"dihydrolipoamide S-acetyltransferase activity",
"dihydrolipoamide S-acyltransferase activity",... | [
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"NARROW"
] | [
"GO:0030523"
] | [] | [
"EC:2.3.1.12",
"Reactome:R-HSA-9861667 \"DLAT trimer transfers acetyl to CoA\"",
"RHEA:17017"
] | [
"GO:0016418",
"GO:0140096"
] | [] | [] | [] | [
"GO:0016418",
"GO:0140096"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:1.2.1.104",
"skos:broadMatch RHEA:28042",
"skos:exactMatch EC:2.3.1.12",
"skos:exactMatch RHEA:17017",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17835\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24350\" xsd:anyURI... | null | null | false | true | 5 |
GO:0004743 | 4,743 | pyruvate kinase activity | molecular_function | Catalysis of the reaction: ADP + H+ + phosphoenolpyruvate = ATP + pyruvate. | [
"RHEA:18157"
] | null | [
"ATP:pyruvate 2-O-phosphotransferase activity",
"phosphoenol transphosphorylase activity",
"phosphoenolpyruvate kinase activity"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.40",
"MetaCyc:PEPDEPHOS-RXN",
"Reactome:R-HSA-71670 \"Pyruvate kinase dephosphorylates PEP to PYR\"",
"RHEA:18157"
] | [
"GO:0016773"
] | [
"part_of GO:0006096"
] | [
"part_of"
] | [
"GO:0006096"
] | [
"GO:0006096",
"GO:0016773"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.40",
"skos:exactMatch MetaCyc:PEPDEPHOS-RXN",
"skos:exactMatch RHEA:18157",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30815\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004744 | 4,744 | obsolete retinal isomerase activity | molecular_function | OBSOLETE. Catalysis of the reaction: all-trans-retinal = 11-cis-retinal. | [
"PMID:21447403"
] | The Enzyme Commission has deleted the EC correspondingj to this term because it is now known to be catalysed by a pathway involving multiple enzymes. | [
"all-trans-retinal 11-cis-trans-isomerase activity",
"retinene isomerase activity",
"retinoid isomerase activity"
] | [
"RELATED",
"RELATED",
"BROAD"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0106434"
] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23098\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23669\" xsd:anyURI"
] | null | null | true | true | 8 |
GO:0004745 | 4,745 | all-trans-retinol dehydrogenase (NAD+) activity | molecular_function | Catalysis of the reaction: all-trans-retinol--[retinol-binding protein] + NAD+ = all-trans-retinal--[retinol-binding protein] + H+ + NADH. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form. | [
"RHEA:48488"
] | null | [
"all-trans retinol dehydrogenase activity",
"retinal reductase activity",
"retinene reductase activity",
"retinol (vitamin A1) dehydrogenase activity",
"retinol dehydrogenase activity"
] | [
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"BROAD"
] | [] | [] | [
"EC:1.1.1.105",
"MetaCyc:RETINOL-DEHYDROGENASE-RXN",
"Reactome:R-HSA-2454081 \"RDH5 oxidises 11cROL to 11cRAL\"",
"Reactome:R-HSA-2466832 \"Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA\"",
"Reactome:R-HSA-5362518 \"RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL\"",
"Reactome:R-HSA-5362564 ... | [
"GO:0004022"
] | [] | [] | [] | [
"GO:0004022"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.105",
"skos:exactMatch RHEA:48488",
"skos:narrowMatch RHEA:21284",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20980\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27136\" xsd:anyURI",
"term_tracker_item \"https:... | null | null | false | true | 9 |
GO:0004747 | 4,747 | ribokinase activity | molecular_function | Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. | [
"EC:2.7.1.15"
] | null | [
"ATP:D-ribose 5-phosphotransferase activity",
"D-ribokinase activity",
"deoxyribokinase activity",
"ribokinase (phosphorylating)"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.15",
"MetaCyc:RIBOKIN-RXN",
"Reactome:R-HSA-8955844 \"RBKS phosphorylates ribose to R5P\"",
"RHEA:13697"
] | [
"GO:0016773",
"GO:0019200"
] | [] | [] | [] | [
"GO:0016773",
"GO:0019200"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.15",
"skos:exactMatch RHEA:13697",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004749 | 4,749 | ribose phosphate diphosphokinase activity | molecular_function | Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H+. | [
"RHEA:15609"
] | null | [
"5-phosphoribose pyrophosphorylase activity",
"5-phosphoribosyl-1-pyrophosphate synthetase activity",
"5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity",
"ATP:D-ribose-5-phosphate diphosphotransferase activity",
"phosphoribosyl diphosphate synthetase activity",
"phosphoribosyl pyrophosphate synt... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:2.7.6.1",
"KEGG_REACTION:R01049",
"MetaCyc:PRPPSYN-RXN",
"Reactome:R-HSA-111215 \"PRPS1 dimer pyrophosphorylates R5P using dATP\"",
"Reactome:R-HSA-73580 \"PRPS dimers pyrophosphorylate R5P using ATP\"",
"RHEA:15609"
] | [
"GO:0016778"
] | [] | [] | [] | [
"GO:0016778"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.6.1",
"skos:exactMatch KEGG_REACTION:R01049",
"skos:exactMatch MetaCyc:PRPPSYN-RXN",
"skos:exactMatch RHEA:15609",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28526\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31... | null | null | false | true | 3 |
GO:0004750 | 4,750 | D-ribulose-phosphate 3-epimerase activity | molecular_function | Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. | [
"EC:5.1.3.1",
"RHEA:13677"
] | null | [
"D-ribulose 5-phosphate epimerase activity",
"D-ribulose phosphate-3-epimerase activity",
"D-ribulose-5-P 3-epimerase activity",
"D-ribulose-5-phosphate 3-epimerase activity",
"D-ribulose-5-phosphate epimerase activity",
"D-xylulose-5-phosphate 3-epimerase activity",
"erythrose-4-phosphate epimerase act... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:5.1.3.1",
"KEGG_REACTION:R01529",
"MetaCyc:RIBULP3EPIM-RXN",
"Reactome:R-HSA-199803 \"RPE dimers isomerize XY5P to RU5P\"",
"Reactome:R-HSA-71303 \"RPE dimers isomerise RU5P to XY5P\"",
"RHEA:13677"
] | [
"GO:0016857"
] | [] | [] | [] | [
"GO:0016857"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.1.3.1",
"skos:exactMatch RHEA:13677",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004751 | 4,751 | ribose-5-phosphate isomerase activity | molecular_function | Catalysis of the reaction: aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate. | [
"RHEA:14657"
] | null | [
"5-phosphoribose isomerase activity",
"D-ribose 5-phosphate isomerase activity",
"D-ribose-5-phosphate aldose-ketose-isomerase activity",
"D-ribose-5-phosphate ketol-isomerase activity",
"pentose phosphate isomerase (PPI)",
"phosphopentoseisomerase activity",
"phosphopentosisomerase activity",
"phosph... | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [
"EC:5.3.1.6",
"KEGG_REACTION:R01056",
"MetaCyc:RIB5PISOM-RXN",
"Reactome:R-HSA-177784 \"RPIA isomerizes ribose 5-phosphate to D-ribulose 5-phosphate\"",
"Reactome:R-HSA-5660013 \"Defective RPIA does not isomerize RU5P to R5P\"",
"Reactome:R-HSA-5660015 \"Defective RPIA does not isomerize R5P to RU5P\"",
... | [
"GO:0016861"
] | [] | [] | [] | [
"GO:0016861"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.3.1.6",
"skos:exactMatch RHEA:14657",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004753 | 4,753 | saccharopine dehydrogenase activity | molecular_function | Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor. | [
"GOC:mah"
] | null | [
"lysine-2-oxoglutarate reductase activity",
"lysine-ketoglutarate reductase activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [] | [
"GO:0016646"
] | [] | [] | [] | [
"GO:0016646"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 1 |
GO:0004754 | 4,754 | saccharopine dehydrogenase (NAD+, L-lysine-forming) activity | molecular_function | Catalysis of the reaction: L-saccharopine + H2O + NAD+ = 2-oxoglutarate + L-lysine + H+ + NADH. | [
"EC:1.5.1.7",
"RHEA:12440"
] | null | [
"6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)",
"dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)",
"epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)",
"N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)",
"N6-... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.5.1.7",
"KEGG_REACTION:R00715",
"MetaCyc:1.5.1.7-RXN",
"RHEA:12440"
] | [
"GO:0004753"
] | [] | [] | [] | [
"GO:0004753"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.5.1.7",
"skos:exactMatch RHEA:12440",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004755 | 4,755 | saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity | molecular_function | Catalysis of the reaction: L-saccharopine + H2O + NADP+ = L-allysine + L-glutamate + H+ + NADPH. | [
"EC:1.5.1.10",
"RHEA:10020"
] | null | [
"6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)",
"aminoadipate semialdehyde-glutamate reductase activity",
"aminoadipic semialdehyde-glutamate reductase activity",
"aminoadipic semialdehyde-glutamic reductase activity",
"epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreduct... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.5.1.10",
"KEGG_REACTION:R02315",
"MetaCyc:RXN3O-127",
"RHEA:10020"
] | [
"GO:0004753"
] | [] | [] | [] | [
"GO:0004753"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.5.1.10",
"skos:exactMatch RHEA:10020",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004756 | 4,756 | selenide, water dikinase activity | molecular_function | Catalysis of the reaction: ATP + H2O + hydrogen selenide = AMP + 3 H+ + phosphate + selenophosphorate. | [
"EC:2.7.9.3",
"RHEA:18737"
] | null | [
"ATP:selenide, water phosphotransferase activity",
"selenide,water dikinase activity",
"selenium donor protein activity",
"selenophosphate synthase activity",
"selenophosphate synthetase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:2.7.9.3",
"KEGG_REACTION:R03595",
"MetaCyc:2.7.9.3-RXN",
"Reactome:R-HSA-8959510 \"SEPHS2 phosphorylates H2Se to form SELP\"",
"RHEA:18737",
"UM-BBD_reactionID:r0833"
] | [
"GO:0016301",
"GO:0016781"
] | [] | [] | [] | [
"GO:0016301",
"GO:0016781"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.9.3",
"skos:exactMatch RHEA:18737",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004757 | 4,757 | sepiapterin reductase (NADP+) activity | molecular_function | Catalysis of the reactions: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H+ + 2 NADPH. | [
"EC:1.1.1.153"
] | null | [
"7,8-dihydrobiopterin:NADP+ oxidoreductase activity"
] | [
"RELATED"
] | [] | [] | [
"EC:1.1.1.153",
"MetaCyc:SEPIAPTERIN-REDUCTASE-RXN",
"Reactome:R-HSA-1475414 \"PTHP is reduced to BH4 by sepiapterin reductase (SPR)\"",
"Reactome:R-HSA-1497869 \"Salvage - Sepiapterin is reduced to q-BH2\"",
"RHEA:18953",
"RHEA:32627"
] | [
"GO:0016616"
] | [] | [] | [] | [
"GO:0016616"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.153",
"skos:narrowMatch RHEA:18953",
"skos:narrowMatch RHEA:32627",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28011\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004758 | 4,758 | serine C-palmitoyltransferase activity | molecular_function | Catalysis of the reaction: L-serine + H+ + palmitoyl-CoA = 3-dehydrosphinganine + CO2 + CoA. | [
"EC:2.3.1.50",
"RHEA:14761"
] | null | [
"3-oxosphinganine synthetase activity",
"serine palmitoyltransferase",
"SPT"
] | [
"RELATED",
"BROAD",
"RELATED"
] | [] | [] | [
"EC:2.3.1.50",
"KEGG_REACTION:R01281",
"MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN",
"Reactome:R-HSA-428127 \"SPTLC complexes transfer acyl-CoA onto serine\"",
"RHEA:14761"
] | [
"GO:0016454"
] | [] | [] | [] | [
"GO:0016454"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.50",
"skos:exactMatch RHEA:14761",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004760 | 4,760 | L-serine:pyruvate transaminase activity | molecular_function | Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine. | [
"RHEA:22852"
] | null | [
"hydroxypyruvate:L-alanine transaminase activity",
"L-serine-pyruvate transaminase activity",
"L-serine:pyruvate aminotransferase activity",
"serine--pyruvate aminotransferase activity",
"serine-pyruvate aminotransferase activity",
"serine-pyruvate aminotransferase, type 1",
"serine-pyruvate aminotransf... | [
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"EXACT",
"NARROW",
"NARROW",
"NARROW",
"RELATED"
] | [
"GO:0004761",
"GO:0004762",
"GO:0004763"
] | [] | [
"EC:2.6.1.51",
"KEGG_REACTION:R00585",
"MetaCyc:SERINE--PYRUVATE-AMINOTRANSFERASE-RXN",
"RHEA:22852"
] | [
"GO:0047635"
] | [] | [] | [] | [
"GO:0047635"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.6.1.51",
"skos:exactMatch RHEA:22852",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31140\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004764 | 4,764 | shikimate 3-dehydrogenase (NADP+) activity | molecular_function | Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+. | [
"EC:1.1.1.25"
] | null | [
"5-dehydroshikimate reductase activity",
"5-dehydroshikimic reductase activity",
"dehydroshikimic reductase activity",
"DHS reductase activity",
"shikimate oxidoreductase activity",
"shikimate:NADP(+) 5-oxidoreductase activity",
"shikimate:NADP(+) oxidoreductase activity"
] | [
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"BROAD",
"RELATED",
"BROAD"
] | [] | [] | [
"EC:1.1.1.25",
"KEGG_REACTION:R02413",
"MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN",
"RHEA:17737"
] | [
"GO:0016616"
] | [] | [] | [] | [
"GO:0016616"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:1.1.1.282",
"skos:exactMatch EC:1.1.1.25",
"skos:exactMatch RHEA:17737",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28133\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004765 | 4,765 | shikimate kinase activity | molecular_function | Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H+. | [
"EC:2.7.1.71",
"RHEA:13121"
] | null | [
"ATP:shikimate 3-phosphotransferase activity",
"shikimate kinase (phosphorylating)",
"shikimate kinase II"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.71",
"KEGG_REACTION:R02412",
"MetaCyc:SHIKIMATE-KINASE-RXN",
"RHEA:13121"
] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.71",
"skos:exactMatch RHEA:13121",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004766 | 4,766 | spermidine synthase activity | molecular_function | Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine. | [
"EC:2.5.1.16"
] | null | [
"aminopropyltransferase activity",
"putrescine aminopropyltransferase activity",
"S-adenosylmethioninamine:putrescine 3-aminopropyltransferase activity",
"SpeE",
"spermidine synthetase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.5.1.16",
"MetaCyc:SPERMIDINESYN-RXN",
"Reactome:R-HSA-351215 \"Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine\"",
"RHEA:12721"
] | [
"GO:0016765"
] | [] | [] | [] | [
"GO:0016765"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.5.1.16",
"skos:exactMatch RHEA:12721",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004767 | 4,767 | sphingomyelin phosphodiesterase activity | molecular_function | Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+. | [
"EC:3.1.4.12",
"RHEA:19253"
] | null | [
"sphingomyelin cholinephosphohydrolase activity",
"sphingomyelinase activity"
] | [
"RELATED",
"EXACT"
] | [
"GO:0030230",
"GO:0030231"
] | [
"goslim_chembl"
] | [
"EC:3.1.4.12",
"KEGG_REACTION:R02541",
"MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN",
"Reactome:R-HSA-1605797 \"SMPD1 hydrolyzes SPHM\"",
"Reactome:R-HSA-1606273 \"SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)\"",
"Reactome:R-HSA-1606288 \"SMPD4 hydrolyzes sphingomyelin (ER membrane)\"",
"Reacto... | [
"GO:0008081",
"GO:0120570"
] | [] | [] | [] | [
"GO:0008081",
"GO:0120570"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.4.12",
"skos:exactMatch RHEA:19253",
"skos:narrowMatch RHEA:45324",
"skos:narrowMatch RHEA:54284",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31030\" xsd:anyURI... | null | null | false | true | 3 |
GO:0004768 | 4,768 | stearoyl-CoA 9-desaturase activity | molecular_function | Catalysis of the reaction: 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. | [
"RHEA:19721"
] | null | [
"acyl-CoA desaturase",
"delta(9)-desaturase activity",
"delta9-desaturase",
"fatty acid desaturase",
"stearoyl-CoA desaturase activity"
] | [
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"BROAD"
] | [
"GO:0016214",
"GO:0043735"
] | [] | [
"EC:1.14.19.1",
"MetaCyc:1.14.19.1-RXN",
"Reactome:R-HSA-5690565 \"SCD desaturates ST-CoA to OLE-CoA\"",
"Reactome:R-HSA-8847579 \"SCD5 desaturates ST-CoA to OLE-CoA\"",
"RHEA:19721"
] | [
"GO:0016215"
] | [] | [] | [] | [
"GO:0016215"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.14.19.1",
"skos:exactMatch RHEA:19721",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24103\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004771 | 4,771 | sterol ester esterase activity | molecular_function | Catalysis of the reaction: a sterol ester + H2O = a fatty acid + a sterol + H+. | [
"RHEA:10100"
] | null | [
"acylcholesterol lipase activity",
"cholesterase activity",
"cholesterol ester hydrolase activity",
"cholesterol ester synthase activity",
"cholesterol esterase activity",
"cholesteryl ester hydrolase activity",
"cholesteryl ester synthase activity",
"cholesteryl esterase activity",
"sterol ester hy... | [
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED"
] | [] | [
"goslim_chembl"
] | [
"EC:3.1.1.13",
"MetaCyc:STEROL-ESTERASE-RXN",
"Reactome:R-HSA-192417 \"Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)\"",
"Reactome:R-HSA-6813720 \"NCEH1 hydrolyzes cholesterol esters\"",
"Reactome:R-HSA-8865667 \"LIPA hydrolyses sterol esters to sterols and fatty acids\""... | [
"GO:0016298",
"GO:0052689"
] | [] | [] | [] | [
"GO:0016298",
"GO:0052689"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.1.13",
"skos:exactMatch MetaCyc:STEROL-ESTERASE-RXN",
"skos:exactMatch RHEA:10100",
"skos:narrowMatch RHEA:33543",
"skos:narrowMatch RHEA:33547",
"skos:narrowMatch RHEA:36403",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28339\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004772 | 4,772 | sterol O-acyltransferase activity | molecular_function | Catalysis of the reaction: a long-chain fatty acyl-CoA + a sterol = a sterol ester + CoA. | [
"RHEA:59816"
] | null | [
"sterol-ester synthase activity",
"sterol-ester synthetase activity"
] | [
"RELATED",
"RELATED"
] | [
"GO:0017066"
] | [] | [
"EC:2.3.1.26",
"MetaCyc:RXN-20233",
"RHEA:59816"
] | [
"GO:0008374"
] | [] | [] | [] | [
"GO:0008374"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.26",
"skos:exactMatch MetaCyc:RXN-20233",
"skos:exactMatch RHEA:59816",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28776\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004773 | 4,773 | steryl-sulfatase activity | molecular_function | Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate. | [
"EC:3.1.6.2"
] | null | [
"3-beta-hydroxysteroid sulfate sulfatase activity",
"arylsulfatase C activity",
"dehydroepiandrosterone sulfatase activity",
"dehydroepiandrosterone sulfate sulfatase activity",
"phenolic steroid sulfatase activity",
"pregnenolone sulfatase activity",
"steroid 3-sulfatase activity",
"steroid sulfatase... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:3.1.6.2",
"MetaCyc:STERYL-SULFATASE-RXN",
"Reactome:R-HSA-1606839 \"ARSC hydrolyzes steroid sulfates\"",
"RHEA:19873"
] | [
"GO:0008484"
] | [] | [] | [] | [
"GO:0008484"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.6.2",
"skos:exactMatch RHEA:19873",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004774 | 4,774 | succinate-CoA ligase activity | molecular_function | Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA. | [
"GOC:ai"
] | null | [] | [] | [] | [] | [] | [
"GO:0016405"
] | [] | [] | [] | [
"GO:0016405"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 2 |
GO:0004775 | 4,775 | succinate-CoA ligase (ADP-forming) activity | molecular_function | Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. | [
"PMID:9874242",
"RHEA:17661"
] | null | [
"succinate thiokinase activity",
"succinic thiokinase",
"succinyl coenzyme A synthetase",
"succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity",
"succinyl-CoA synthetase (ADP-forming) activity",
"succinyl-CoA synthetase activity"
] | [
"RELATED",
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.2.1.5",
"KEGG_REACTION:R00405",
"MetaCyc:SUCCCOASYN-RXN",
"Reactome:R-HSA-70997 \"SUCLG1/A2 cleaves succinyl-CoA\"",
"RHEA:17661"
] | [
"GO:0004774"
] | [] | [] | [] | [
"GO:0004774"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.2.1.5",
"skos:exactMatch RHEA:17661",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004776 | 4,776 | succinate-CoA ligase (GDP-forming) activity | molecular_function | Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate. | [
"RHEA:22120"
] | null | [
"succinate:CoA ligase (GDP-forming) activity",
"succinyl CoA synthetase activity",
"succinyl coenzyme A synthetase",
"succinyl coenzyme A synthetase (GDP-forming) activity",
"succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity",
"succinyl-CoA synthetase (GDP-forming) activity"
] | [
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.2.1.4",
"KEGG_REACTION:R00432",
"MetaCyc:SUCCINATE--COA-LIGASE-GDP-FORMING-RXN",
"Reactome:R-HSA-71775 \"SUCLG1/G2 cleaves succinyl-CoA\"",
"RHEA:22120"
] | [
"GO:0004774"
] | [] | [] | [] | [
"GO:0004774"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.2.1.4",
"skos:exactMatch RHEA:22120",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004777 | 4,777 | succinate-semialdehyde dehydrogenase (NAD+) activity | molecular_function | Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+. | [
"RHEA:13217"
] | null | [
"succinate semialdehyde dehydrogenase activity",
"succinate semialdehyde:NAD+ oxidoreductase activity",
"succinate-semialdehyde dehydrogenase activity",
"succinate-semialdehyde:NAD+ oxidoreductase activity",
"succinic semialdehyde dehydrogenase activity",
"succinyl semialdehyde dehydrogenase activity"
] | [
"BROAD",
"RELATED",
"BROAD",
"RELATED",
"BROAD",
"RELATED"
] | [
"GO:0008952"
] | [] | [
"EC:1.2.1.24",
"MetaCyc:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN",
"Reactome:R-HSA-888548 \"ALDH5A1 dehydrogenates SUCCSA to SUCCA\"",
"RHEA:13217"
] | [
"GO:0009013"
] | [] | [] | [] | [
"GO:0009013"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.2.1.24",
"skos:exactMatch RHEA:13217",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004778 | 4,778 | succinyl-CoA hydrolase activity | molecular_function | Catalysis of the reaction: H2O + succinyl-CoA = CoA + H+ + succinate. | [
"EC:3.1.2.3",
"RHEA:11516"
] | null | [
"succinyl coenzyme A deacylase activity",
"succinyl coenzyme A hydrolase activity",
"succinyl-CoA acylase activity"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.1.2.3",
"KEGG_REACTION:R00407",
"MetaCyc:SUCCINYL-COA-HYDROLASE-RXN",
"RHEA:11516"
] | [
"GO:0016289"
] | [] | [] | [] | [
"GO:0016289"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.2.3",
"skos:exactMatch RHEA:11516",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004780 | 4,780 | sulfate adenylyltransferase (ADP) activity | molecular_function | Catalysis of the reaction: ADP + H+ + sulfate = 5'-adenylyl sulfate + phosphate. | [
"EC:2.7.7.5",
"RHEA:16529"
] | null | [
"adenosine diphosphate sulfurylase activity",
"ADP-sulfurylase activity",
"ADP:sulfate adenylyltransferase activity",
"sulfate (adenosine diphosphate) adenylyltransferase activity",
"sulphate adenylyltransferase (ADP) activity"
] | [
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:2.7.7.5",
"KEGG_REACTION:R00530",
"MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN",
"RHEA:16529"
] | [
"GO:0004779"
] | [] | [] | [] | [
"GO:0004779"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.7.5",
"skos:exactMatch RHEA:16529",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004781 | 4,781 | sulfate adenylyltransferase (ATP) activity | molecular_function | Catalysis of the reaction: ATP + H+ + sulfate = adenosine 5'-phosphosulfate + diphosphate. | [
"EC:2.7.7.4"
] | null | [
"adenosine-5'-triphosphate sulfurylase activity",
"adenosinetriphosphate sulfurylase activity",
"adenylylsulfate pyrophosphorylase activity",
"ATP sulfurylase activity",
"ATP-sulfurylase activity",
"ATP:sulfate adenylyltransferase activity",
"sulfate adenylate transferase activity",
"sulfurylase activ... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:2.7.7.4",
"MetaCyc:SULFATE-ADENYLYLTRANS-RXN",
"Reactome:R-HSA-174392 \"PAPSS1,2 transfer SO4(2-) group to ATP to form APS\"",
"Reactome:R-HSA-3560794 \"Defective PAPSS2 does not transfer SO4(2-) group to ATP to form APS\"",
"RHEA:18133"
] | [
"GO:0004779"
] | [] | [] | [] | [
"GO:0004779"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.7.4",
"skos:exactMatch RHEA:18133",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28907\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004782 | 4,782 | sulfinoalanine decarboxylase activity | molecular_function | Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2. | [
"EC:4.1.1.29"
] | null | [
"3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)",
"3-sulfino-L-alanine carboxy-lyase activity",
"CADCase/CSADCase activity",
"CSAD",
"CSADCase activity",
"cysteic decarboxylase activity",
"cysteine-sulfinate decarboxylase activity",
"cysteinesulfinate decarboxylase activity",
"cysteinesulfi... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:4.1.1.29",
"MetaCyc:SULFINOALANINE-DECARBOXYLASE-RXN",
"Reactome:R-HSA-1655443 \"PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine\"",
"RHEA:16877"
] | [
"GO:0016831"
] | [] | [] | [] | [
"GO:0016831"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.1.29",
"skos:exactMatch RHEA:16877",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004786 | 4,786 | obsolete Mn, Fe superoxide dismutase | molecular_function | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:curators"
] | This term was made obsolete because the function is covered by an existing term. | [
"Mn, Fe superoxide dismutase"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004784"
] | [] | null | null | true | true | 3 |
GO:0004787 | 4,787 | thiamine diphosphate phosphatase activity | molecular_function | Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate. | [
"GOC:ai",
"RHEA:27998"
] | null | [
"thiamin pyrophosphatase activity",
"thiamin-pyrophosphatase activity",
"thiamine diphosphatase activity",
"thiamine pyrophosphatase activity",
"thiamine-diphosphatase activity",
"thiaminpyrophosphatase activity",
"TPPase activity"
] | [
"EXACT",
"EXACT",
"BROAD",
"EXACT",
"EXACT",
"RELATED",
"EXACT"
] | [] | [] | [
"RHEA:27998"
] | [
"GO:0016462"
] | [] | [] | [] | [
"GO:0016462"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch RHEA:27998",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23401\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004788 | 4,788 | thiamine diphosphokinase activity | molecular_function | Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate. | [
"RHEA:11576"
] | null | [
"ATP:thiamin pyrophosphotransferase activity",
"ATP:thiamine diphosphotransferase activity",
"thiamin diphosphokinase activity",
"thiamin pyrophosphokinase activity",
"thiamin pyrophosphotransferase activity",
"thiamin:ATP pyrophosphotransferase activity",
"thiamine pyrophosphokinase activity",
"thiam... | [
"RELATED",
"RELATED",
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.6.2",
"MetaCyc:THIAMIN-PYROPHOSPHOKINASE-RXN",
"Reactome:R-HSA-196761 \"2xTPK1:Mg2+ phosphorylates THMN\"",
"RHEA:11576"
] | [
"GO:0016778"
] | [] | [] | [] | [
"GO:0016778"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.6.2",
"skos:exactMatch RHEA:11576",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004789 | 4,789 | thiamine-phosphate diphosphorylase activity | molecular_function | Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H+ = diphosphate + thiamine phosphate. | [
"EC:2.5.1.3",
"RHEA:22328"
] | null | [
"2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase activity",
"thiamin-phosphate diphosphorylase activity",
"thiamin-phosphate pyrophosphorylase activity",
"thiamine monophosphate pyrophosphorylase activity",
"thiamine... | [
"RELATED",
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.5.1.3",
"KEGG_REACTION:R03223",
"MetaCyc:THI-P-SYN-RXN",
"RHEA:22328"
] | [
"GO:0016765"
] | [] | [] | [] | [
"GO:0016765"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.5.1.3",
"skos:exactMatch RHEA:22328",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004790 | 4,790 | thioether S-methyltransferase activity | molecular_function | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium. | [
"EC:2.1.1.96",
"RHEA:19613"
] | null | [
"S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase activity",
"S-adenosyl-L-methionine:thioether S-methyltransferase activity",
"thioether methyltransferase activity"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.1.1.96",
"KEGG_REACTION:R02572",
"MetaCyc:THIOETHER-S-METHYLTRANSFERASE-RXN",
"RHEA:19613"
] | [
"GO:0008172",
"GO:0008757"
] | [] | [] | [] | [
"GO:0008172",
"GO:0008757"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.1.1.96",
"skos:exactMatch RHEA:19613",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004791 | 4,791 | thioredoxin-disulfide reductase (NADPH) activity | molecular_function | Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH. | [
"RHEA:20345"
] | null | [
"NADPH:oxidized thioredoxin oxidoreductase activity",
"thioredoxin disulfide reductase activity",
"thioredoxin reductase (NADPH) activity",
"thioredoxin-disulfide reductase (NADP) activity",
"thioredoxin-disulfide reductase activity",
"thioredoxin-disulphide reductase activity"
] | [
"EXACT",
"BROAD",
"EXACT",
"EXACT",
"BROAD",
"BROAD"
] | [] | [] | [
"EC:1.8.1.9",
"KEGG_REACTION:R02016",
"MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN",
"Reactome:R-HSA-1222485 \"TrxB reactivates TrxA\"",
"Reactome:R-HSA-3323050 \"TXNRD2 catalyzes the reduction of TXN2 by NADPH\"",
"Reactome:R-HSA-73646 \"thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+\"",
"... | [
"GO:0016209",
"GO:0047134"
] | [] | [] | [] | [
"GO:0016209",
"GO:0047134"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.8.1.9",
"skos:exactMatch RHEA:20345",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22101\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25459\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontolo... | null | null | false | true | 3 |
GO:0004792 | 4,792 | thiosulfate-cyanide sulfurtransferase activity | molecular_function | Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+. | [
"RHEA:16881"
] | null | [
"rhodanase activity",
"rhodanese activity",
"thiosulfate cyanide transsulfurase activity",
"thiosulfate sulfurtransferase activity",
"thiosulfate thiotransferase activity",
"thiosulfate:cyanide sulfurtransferase activity",
"thiosulphate sulphurtransferase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"BROAD"
] | [] | [] | [
"EC:2.8.1.1",
"KEGG_REACTION:R01931",
"MetaCyc:THIOSULFATE-SULFURTRANSFERASE-RXN",
"Reactome:R-HSA-9013198 \"TST transfers sulfur from S2O3(2-) to HCN to form HSCN\"",
"RHEA:16881"
] | [
"GO:0016783"
] | [] | [] | [] | [
"GO:0016783"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.8.1.1",
"skos:exactMatch RHEA:16881",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004793 | 4,793 | threonine aldolase activity | molecular_function | Catalysis of the reaction: L-threonine = glycine + acetaldehyde. | [
"RHEA:19625"
] | null | [
"L-threonine acetaldehyde-lyase (glycine-forming)",
"L-threonine acetaldehyde-lyase activity",
"L-threonine aldolase activity"
] | [
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:4.1.2.5",
"MetaCyc:THREONINE-ALDOLASE-RXN",
"RHEA:19625"
] | [
"GO:0016832"
] | [] | [] | [] | [
"GO:0016832"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:2.1.2.1",
"skos:broadMatch EC:4.1.2.48",
"skos:exactMatch EC:4.1.2.5",
"skos:exactMatch MetaCyc:THREONINE-ALDOLASE-RXN",
"skos:exactMatch RHEA:19625",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30653\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004794 | 4,794 | threonine deaminase activity | molecular_function | Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH4. | [
"EC:4.3.1.19"
] | null | [
"L-serine dehydratase activity",
"L-threonine ammonia-lyase (2-oxobutanoate-forming)",
"L-threonine ammonia-lyase activity",
"L-threonine deaminase activity",
"L-threonine dehydratase activity",
"L-threonine hydro-lyase (deaminating) activity",
"serine deaminase activity",
"threonine ammonia-lyase act... | [
"RELATED",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"BROAD",
"EXACT",
"BROAD"
] | [] | [] | [
"EC:4.3.1.19",
"MetaCyc:THREDEHYD-RXN",
"Reactome:R-HSA-9014627 \"SDS dimers:PXLP convert L-Thr to 2OBUTA\"",
"RHEA:22108",
"UM-BBD_reactionID:r0433"
] | [
"GO:0016841"
] | [] | [] | [] | [
"GO:0016841"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.3.1.19",
"skos:exactMatch RHEA:22108",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004795 | 4,795 | threonine synthase activity | molecular_function | Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate. | [
"EC:4.2.3.1"
] | null | [
"O-phospho-L-homoserine phospho-lyase (adding water)",
"O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)",
"threonine synthetase activity"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.2.3.1",
"MetaCyc:THRESYN-RXN",
"RHEA:10840"
] | [
"GO:0016838"
] | [] | [] | [] | [
"GO:0016838"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.2.3.1",
"skos:exactMatch RHEA:10840",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004796 | 4,796 | thromboxane-A synthase activity | molecular_function | Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2). | [
"EC:5.3.99.5",
"RHEA:17137"
] | null | [
"(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity",
"(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity",
"cytochrome P450 CYP5",
"thromboxane synthase activity",
"thromboxane synthetase activity"
] | [
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"RELATED"
] | [
"GO:0008400"
] | [] | [
"EC:5.3.99.5",
"KEGG_REACTION:R02268",
"MetaCyc:THROMBOXANE-A-SYNTHASE-RXN",
"Reactome:R-HSA-5603275 \"Defective TBXAS1 does not isomerise PGH2 to TXA2\"",
"Reactome:R-HSA-76500 \"TBXAS1 isomerises PGH2 to TXA2\"",
"RHEA:17137"
] | [
"GO:0016860"
] | [] | [] | [] | [
"GO:0016860"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.3.99.5",
"skos:exactMatch RHEA:17137",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004797 | 4,797 | thymidine kinase activity | molecular_function | Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. | [
"EC:2.7.1.21"
] | null | [
"2'-deoxythymidine kinase activity",
"ATP:thymidine 5'-phosphotransferase activity",
"deoxythymidine kinase (phosphorylating)",
"thymidine kinase (phosphorylating)"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.21",
"MetaCyc:THYKI-RXN",
"RHEA:19129"
] | [
"GO:0019136"
] | [] | [] | [] | [
"GO:0019136"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.21",
"skos:exactMatch RHEA:19129",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004798 | 4,798 | dTMP kinase activity | molecular_function | Catalysis of the reaction: dTMP + ATP = dTDP + ADP. | [
"RHEA:13517"
] | null | [
"ATP:dTMP phosphotransferase activity",
"deoxythymidine 5'-monophosphate kinase activity",
"thymidine 5'-monophosphate kinase activity",
"thymidine monophosphate kinase activity",
"thymidylate kinase activity",
"thymidylate monophosphate kinase activity",
"thymidylic acid kinase activity",
"thymidylic... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.4.9",
"MetaCyc:DTMPKI-RXN",
"RHEA:13517"
] | [
"GO:0047507"
] | [] | [] | [] | [
"GO:0047507"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:2.7.4.12",
"skos:exactMatch EC:2.7.4.9",
"skos:exactMatch MetaCyc:DTMPKI-RXN",
"skos:exactMatch RHEA:13517",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29533\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004799 | 4,799 | thymidylate synthase activity | molecular_function | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. | [
"EC:2.1.1.45",
"RHEA:12104"
] | null | [
"5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity",
"dTMP synthase activity",
"methylenetetrahydrofolate:dUMP C-methyltransferase activity",
"thymidylate synthetase activity",
"TMP synthetase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.1.1.45",
"KEGG_REACTION:R02101",
"MetaCyc:THYMIDYLATESYN-RXN",
"Reactome:R-HSA-73605 \"dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate\"",
"RHEA:12104"
] | [
"GO:0042083"
] | [] | [] | [] | [
"GO:0042083"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.1.1.45",
"skos:exactMatch RHEA:12104",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004800 | 4,800 | thyroxine 5'-deiodinase activity | molecular_function | Catalysis of the reaction: 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + acceptor-H2. | [
"RHEA:19745"
] | null | [
"acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)",
"diiodothyronine 5'-deiodinase activity",
"iodothyronine 5'-deiodinase activity",
"iodothyronine outer ring monodeiodinase activity",
"L-thyroxine iodohydrolase (reducing) activity",
"outer ring-deiodinating pathway",
"thyroxine 5' deiod... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"EXACT",
"BROAD",
"NARROW",
"NARROW"
] | [] | [] | [
"EC:1.21.99.4",
"MetaCyc:THYROXINE-DEIODINASE-RXN",
"Reactome:R-HSA-209772 \"Thyroxine is deiodinated to triiodothyronine\"",
"RHEA:19745"
] | [
"GO:0046992"
] | [] | [] | [] | [
"GO:0046992"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.21.99.4",
"skos:exactMatch RHEA:19745",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29701\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004801 | 4,801 | transaldolase activity | molecular_function | Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. | [
"PMID:7592346",
"RHEA:17053"
] | null | [
"dihydroxyacetone transferase activity",
"dihydroxyacetonetransferase activity",
"glycerone transferase activity",
"sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity"
] | [
"BROAD",
"BROAD",
"BROAD",
"EXACT"
] | [] | [] | [
"EC:2.2.1.2",
"MetaCyc:TRANSALDOL-RXN",
"Reactome:R-HSA-163764 \"D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate\"",
"Reactome:R-HSA-5659989 \"Defective TALDO1 does not transform SH7P, GA3P to Fru(6)P, E4P\"",
"Reactome:R-HSA-5659998 \"Defectiv... | [
"GO:0016744"
] | [] | [] | [] | [
"GO:0016744"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.2.1.2",
"skos:exactMatch RHEA:17053",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20486\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004802 | 4,802 | transketolase activity | molecular_function | Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor. | [
"EC:2.2.1.1",
"GOC:fmc"
] | null | [
"fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity",
"glycoaldehyde transferase activity",
"glycolaldehydetransferase activity",
"sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity"
] | [
"NARROW",
"RELATED",
"RELATED",
"NARROW"
] | [] | [] | [
"EC:2.2.1.1",
"MetaCyc:1TRANSKETO-RXN",
"MetaCyc:2TRANSKETO-RXN",
"Reactome:R-HSA-163741 \"D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate\"",
"Reactome:R-HSA-163751 \"D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-ery... | [
"GO:0016744"
] | [] | [] | [] | [
"GO:0016744"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.2.1.1",
"skos:narrowMatch MetaCyc:1TRANSKETO-RXN",
"skos:narrowMatch MetaCyc:2TRANSKETO-RXN",
"skos:narrowMatch RHEA:10508",
"skos:narrowMatch RHEA:27626",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29091\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004803 | 4,803 | transposase activity | molecular_function | Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. | [
"GOC:bm",
"ISBN:0198506732"
] | null | [
"P-element encoded transposase activity"
] | [
"NARROW"
] | [
"GO:0004804"
] | [
"goslim_metagenomics",
"goslim_pir"
] | [] | [
"GO:0140097"
] | [] | [] | [] | [
"GO:0140097"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 8 |
GO:0004805 | 4,805 | trehalose-phosphatase activity | molecular_function | Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate. | [
"EC:3.1.3.12",
"RHEA:23420"
] | null | [
"trehalose 6-phosphatase activity",
"trehalose 6-phosphate phosphatase activity",
"trehalose phosphatase activity",
"trehalose-6-phosphate phosphohydrolase activity"
] | [
"RELATED",
"RELATED",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:3.1.3.12",
"MetaCyc:TREHALOSEPHOSPHA-RXN",
"RHEA:23420"
] | [
"GO:0050308"
] | [] | [] | [] | [
"GO:0050308"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.3.12",
"skos:exactMatch RHEA:23420",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26845\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004806 | 4,806 | triacylglycerol lipase activity | molecular_function | Catalysis of the reaction: a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+. | [
"RHEA:12044"
] | null | [
"amano AP",
"amano B",
"amano CE",
"amano CES",
"amano P",
"amno N-AP",
"butyrinase activity",
"cacordase activity",
"capalase L",
"GA 56",
"GEH",
"glycerol ester hydrolase activity",
"glycerol-ester hydrolase activity",
"heparin releasable hepatic lipase",
"hepatic lipase",
"hepatic m... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"NARROW",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"NARROW",
"RELATED",
"EXACT",
... | [] | [
"goslim_chembl"
] | [
"EC:3.1.1.3",
"MetaCyc:RXN-19278",
"Reactome:R-HSA-1482777 \"TAG is hydrolyzed to DAG by PNPLA2/3\"",
"Reactome:R-HSA-163551 \"triacylglycerol + H2O -> diacylglycerol + fatty acid\"",
"Reactome:R-HSA-5694109 \"LIPC dimer hydrolyses TAG to DAG and FA\"",
"Reactome:R-HSA-8848338 \"PNPLA4 hydrolyzes TAG\"",
... | [
"GO:0016298",
"GO:0052689"
] | [] | [] | [] | [
"GO:0016298",
"GO:0052689"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:3.1.1.79",
"skos:exactMatch EC:3.1.1.3",
"skos:exactMatch MetaCyc:RXN-19278",
"skos:exactMatch RHEA:12044",
"skos:narrowMatch RHEA:35667",
"skos:narrowMatch RHEA:38495",
"skos:narrowMatch RHEA:38575",
"skos:narrowMatch RHEA:40475",
"skos:narrowMatch RHEA:47864",
"skos:narrowMat... | null | null | false | true | 3 |
GO:0004807 | 4,807 | triose-phosphate isomerase activity | molecular_function | Catalysis of the reaction: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate. | [
"RHEA:18585"
] | null | [
"D-glyceraldehyde-3-phosphate aldose-ketose-isomerase activity",
"D-glyceraldehyde-3-phosphate ketol-isomerase activity",
"phosphotriose isomerase activity",
"triose phosphate mutase activity",
"triose phosphoisomerase activity",
"triosephosphate isomerase activity",
"triosephosphate mutase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:5.3.1.1",
"KEGG_REACTION:R01015",
"MetaCyc:TRIOSEPISOMERIZATION-RXN",
"Reactome:R-HSA-70454 \"TPI1 dimer isomerizes DHAP to GA3P\"",
"Reactome:R-HSA-70481 \"TPI1 dimer isomerizes GA3P to DHAP\"",
"RHEA:18585"
] | [
"GO:0016861"
] | [] | [] | [] | [
"GO:0016861"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.3.1.1",
"skos:exactMatch RHEA:18585",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004808 | 4,808 | tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity | molecular_function | Catalysis of the reaction: 5-aminomethyl-2-thiouridine34 in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine34 in tRNA + H+ + S-adenosyl-L-homocysteine. This enzyme specifically adds the terminal methyl group of 5-[(methylamino)methyl]-2-thiouridylate. | [
"RHEA:19569"
] | null | [
"tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity",
"tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity"
] | [
"EXACT",
"RELATED"
] | [
"GO:0016425"
] | [] | [
"EC:2.1.1.61",
"KEGG_REACTION:R00601",
"MetaCyc:RXN0-5144",
"RHEA:19569"
] | [
"GO:0008757",
"GO:0016300"
] | [] | [] | [] | [
"GO:0008757",
"GO:0016300"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.1.1.61",
"skos:exactMatch RHEA:19569",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26144\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004810 | 4,810 | CCA tRNA nucleotidyltransferase activity | molecular_function | Catalysis of the reaction: a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate. | [
"PMID:2247609",
"RHEA:14433"
] | null | [
"ATP(CTP)-tRNA nucleotidyltransferase",
"ATP(CTP):tRNA nucleotidyltransferase activity",
"CCA-adding enzyme activity",
"CTP(ATP):tRNA nucleotidyltransferase",
"CTP:tRNA cytidylyltransferase activity",
"ribonucleic cytidylic cytidylic adenylic pyrophosphorylase",
"ribonucleic cytidylyltransferase",
"tr... | [
"BROAD",
"BROAD",
"RELATED",
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"RELATED",
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"BROAD"
] | [
"GO:0016437"
] | [] | [
"EC:2.7.7.72",
"MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN",
"RHEA:14433"
] | [
"GO:0070567",
"GO:0140101"
] | [] | [] | [] | [
"GO:0070567",
"GO:0140101"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.7.72",
"skos:exactMatch RHEA:14433",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19854\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004814 | 4,814 | arginine-tRNA ligase activity | molecular_function | Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). | [
"EC:6.1.1.19"
] | null | [
"arginine translase activity",
"arginine-tRNA synthetase activity",
"arginyl transfer ribonucleic acid synthetase activity",
"arginyl-transfer ribonucleate synthetase activity",
"arginyl-transfer RNA synthetase activity",
"arginyl-tRNA synthetase activity",
"L-arginine:tRNAArg ligase (AMP-forming)"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:6.1.1.19",
"MetaCyc:ARGININE--TRNA-LIGASE-RXN",
"Reactome:R-HSA-379993 \"arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380224 \"arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate\"",
"RHEA:20301"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.19",
"skos:exactMatch RHEA:20301",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004815 | 4,815 | aspartate-tRNA ligase activity | molecular_function | Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). | [
"EC:6.1.1.12"
] | null | [
"aspartic acid translase activity",
"aspartyl ribonucleate synthetase activity",
"aspartyl ribonucleic synthetase activity",
"aspartyl-transfer ribonucleic acid synthetase activity",
"aspartyl-transfer RNA synthetase activity",
"aspartyl-tRNA synthetase activity",
"L-aspartate:tRNAAsp ligase (AMP-formin... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:6.1.1.12",
"MetaCyc:ASPARTATE--TRNA-LIGASE-RXN",
"Reactome:R-HSA-379867 \"aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380229 \"aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate\"",
"RHEA:19649"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.12",
"skos:exactMatch RHEA:19649",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004817 | 4,817 | cysteine-tRNA ligase activity | molecular_function | Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). | [
"EC:6.1.1.16"
] | null | [
"cysteine translase activity",
"cysteinyl-transfer ribonucleate synthetase activity",
"cysteinyl-transferRNA synthetase activity",
"cysteinyl-tRNA synthetase activity",
"L-cysteine:tRNACys ligase (AMP-forming)"
] | [
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:6.1.1.16",
"MetaCyc:CYSTEINE--TRNA-LIGASE-RXN",
"Reactome:R-HSA-379887 \"cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380158 \"cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate\"",
"RHEA:17773"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.16",
"skos:exactMatch RHEA:17773",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004818 | 4,818 | glutamate-tRNA ligase activity | molecular_function | Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). | [
"EC:6.1.1.17"
] | null | [
"glutamate-tRNA synthetase activity",
"glutamic acid translase activity",
"glutamyl-transfer ribonucleate synthetase activity",
"glutamyl-transfer ribonucleic acid synthetase activity",
"glutamyl-transfer RNA synthetase activity",
"glutamyl-tRNA synthetase activity",
"L-glutamate:tRNAGlu ligase (AMP-for... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:6.1.1.17",
"MetaCyc:GLURS-RXN",
"Reactome:R-HSA-379861 \"glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380216 \"glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate\"",
"RHEA:23540"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.17",
"skos:exactMatch RHEA:23540",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004819 | 4,819 | glutamine-tRNA ligase activity | molecular_function | Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). | [
"EC:6.1.1.18"
] | null | [
"GlnRS",
"glutamine translase activity",
"glutamine-tRNA synthetase activity",
"glutaminyl ribonucleic acid",
"glutaminyl-transfer ribonucleate synthetase activity",
"glutaminyl-transfer RNA synthetase activity",
"glutaminyl-tRNA synthetase activity",
"L-glutamine:tRNAGln ligase (AMP-forming)"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:6.1.1.18",
"MetaCyc:GLUTAMINE--TRNA-LIGASE-RXN",
"Reactome:R-HSA-379982 \"glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380241 \"glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate\"",
"RHEA:20121"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.18",
"skos:exactMatch RHEA:20121",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004821 | 4,821 | histidine-tRNA ligase activity | molecular_function | Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). | [
"EC:6.1.1.21"
] | null | [
"histidine translase activity",
"histidyl-transfer ribonucleate synthetase activity",
"histidyl-tRNA synthetase activity",
"L-histidine:tRNAHis ligase (AMP-forming)"
] | [
"RELATED",
"RELATED",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:6.1.1.21",
"MetaCyc:HISTIDINE--TRNA-LIGASE-RXN",
"Reactome:R-HSA-379844 \"histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380234 \"histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate\"",
"RHEA:17313"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.21",
"skos:exactMatch RHEA:17313",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004822 | 4,822 | isoleucine-tRNA ligase activity | molecular_function | Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+. | [
"EC:6.1.1.5",
"RHEA:11060"
] | null | [
"isoleucine translase activity",
"isoleucine-transfer RNA ligase activity",
"isoleucine-tRNA synthetase activity",
"isoleucyl-transfer ribonucleate synthetase activity",
"isoleucyl-transfer RNA synthetase activity",
"isoleucyl-tRNA synthetase activity",
"L-isoleucine:tRNAIle ligase (AMP-forming)"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:6.1.1.5",
"KEGG_REACTION:R03656",
"MetaCyc:ISOLEUCINE--TRNA-LIGASE-RXN",
"Reactome:R-HSA-379893 \"isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380176 \"isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate\"",
"RHEA:11060"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.5",
"skos:exactMatch RHEA:11060",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004823 | 4,823 | leucine-tRNA ligase activity | molecular_function | Catalysis of the reaction: leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H+ + Leu-tRNA(Leu). | [
"RHEA:11688"
] | null | [
"leucine translase activity",
"leucine-tRNA synthetase activity",
"leucine:tRNALeu ligase (AMP-forming)",
"leucyl-transfer ribonucleate synthetase activity",
"leucyl-transfer ribonucleic acid synthetase activity",
"leucyl-transfer RNA synthetase activity",
"leucyl-tRNA synthetase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:6.1.1.4",
"KEGG_REACTION:R03657",
"MetaCyc:LEUCINE--TRNA-LIGASE-RXN",
"Reactome:R-HSA-379974 \"leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380200 \"leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate\"",
"RHEA:11688"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.4",
"skos:exactMatch RHEA:11688",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004824 | 4,824 | lysine-tRNA ligase activity | molecular_function | Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). | [
"EC:6.1.1.6"
] | null | [
"L-lysine-transfer RNA ligase activity",
"L-lysine:tRNALys ligase (AMP-forming)",
"lysine translase activity",
"lysine-tRNA synthetase activity",
"lysyl-transfer ribonucleate synthetase activity",
"lysyl-transfer RNA synthetase activity",
"lysyl-tRNA synthetase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:6.1.1.6",
"MetaCyc:LYSINE--TRNA-LIGASE-RXN",
"Reactome:R-HSA-380008 \"lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380233 \"lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate\"",
"RHEA:20792"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.6",
"skos:exactMatch RHEA:20792",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004825 | 4,825 | methionine-tRNA ligase activity | molecular_function | Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). | [
"EC:6.1.1.10"
] | null | [
"L-methionine:tRNAMet ligase (AMP-forming)",
"methionine translase activity",
"methionyl-transfer ribonucleate synthetase activity",
"methionyl-transfer ribonucleic acid synthetase activity",
"methionyl-transfer RNA synthetase activity",
"methionyl-tRNA synthetase activity",
"MetRS activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:6.1.1.10",
"MetaCyc:METHIONINE--TRNA-LIGASE-RXN",
"Reactome:R-HSA-379994 \"methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380157 \"methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate\"",
"RHEA:13481"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.10",
"skos:exactMatch RHEA:13481",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004826 | 4,826 | phenylalanine-tRNA ligase activity | molecular_function | Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). | [
"EC:6.1.1.20"
] | null | [
"L-phenylalanine:tRNAPhe ligase (AMP-forming) activity",
"L-phenylalanyl-tRNA synthetase activity",
"phenylalanine translase activity",
"phenylalanine-tRNA synthetase activity",
"phenylalanyl-transfer ribonucleate synthetase activity",
"phenylalanyl-transfer RNA ligase activity",
"phenylalanyl-transfer ... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:6.1.1.20",
"MetaCyc:PHENYLALANINE--TRNA-LIGASE-RXN",
"Reactome:R-HSA-379848 \"phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380203 \"phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate\"",
"RHEA:19413"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.20",
"skos:exactMatch RHEA:19413",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004827 | 4,827 | proline-tRNA ligase activity | molecular_function | Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). | [
"EC:6.1.1.15"
] | null | [
"L-proline:tRNAPro ligase (AMP-forming)",
"proline translase activity",
"prolinyl-tRNA ligase activity",
"prolyl-s-RNA synthetase activity",
"prolyl-transfer ribonucleate synthetase activity",
"prolyl-transfer ribonucleic acid synthetase activity",
"prolyl-transferRNA synthetase activity",
"prolyl-tRN... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:6.1.1.15",
"MetaCyc:PROLINE--TRNA-LIGASE-RXN",
"Reactome:R-HSA-379865 \"proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380198 \"proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate\"",
"RHEA:14305"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.15",
"skos:exactMatch RHEA:14305",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004828 | 4,828 | serine-tRNA ligase activity | molecular_function | Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). Also catalyzes the formation of L-seryl-tRNA(Sec) from tRNA(Sec), the special tRNA for selenocysteine. | [
"EC:6.1.1.11"
] | null | [
"L-serine:tRNASer ligase (AMP-forming)",
"serine translase activity",
"SerRS activity",
"seryl-transfer ribonucleate synthetase activity",
"seryl-transfer ribonucleic acid synthetase activity",
"seryl-transfer RNA synthetase activity",
"seryl-tRNA synthetase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:6.1.1.11",
"MetaCyc:SERINE--TRNA-LIGASE-RXN",
"Reactome:R-HSA-379992 \"serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380239 \"serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate\"",
"RHEA:12292",
"RHEA:42580"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.11",
"skos:narrowMatch RHEA:12292",
"skos:narrowMatch RHEA:42580",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28011\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004829 | 4,829 | threonine-tRNA ligase activity | molecular_function | Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). | [
"EC:6.1.1.3"
] | null | [
"L-threonine:tRNAThr ligase (AMP-forming)",
"threonine translase activity",
"threonine-transfer ribonucleate synthetase activity",
"threonyl ribonucleic synthetase activity",
"threonyl-transfer ribonucleate synthetase activity",
"threonyl-transfer ribonucleic acid synthetase activity",
"threonyl-transfe... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED"
] | [] | [] | [
"EC:6.1.1.3",
"MetaCyc:THREONINE--TRNA-LIGASE-RXN",
"Reactome:R-HSA-380002 \"threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380201 \"threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate\"",
"RHEA:24624"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.3",
"skos:exactMatch RHEA:24624",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004830 | 4,830 | tryptophan-tRNA ligase activity | molecular_function | Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). | [
"EC:6.1.1.2"
] | null | [
"L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity",
"L-tryptophan-tRNATrp ligase (AMP-forming)",
"L-tryptophan:tRNATrp ligase (AMP-forming)",
"TrpRS activity",
"tryptophan translase activity",
"tryptophanyl ribonucleic synthetase activity",
"tryptophanyl-transfer ribonucleate synthetase activity",
... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:6.1.1.2",
"MetaCyc:TRYPTOPHAN--TRNA-LIGASE-RXN",
"Reactome:R-HSA-379977 \"tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380222 \"tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate\"",
"RHEA:24080"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.2",
"skos:exactMatch RHEA:24080",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004831 | 4,831 | tyrosine-tRNA ligase activity | molecular_function | Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+. | [
"EC:6.1.1.1",
"RHEA:10220"
] | null | [
"L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity",
"L-tyrosine-tRNATyr ligase (AMP-forming)",
"L-tyrosine:tRNATyr ligase (AMP-forming)",
"tyrosine translase activity",
"tyrosine tRNA synthetase activity",
"tyrosine-transfer ribonucleate synthetase activity",
"tyrosine-transfer RNA ligase activity",
... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:6.1.1.1",
"KEGG_REACTION:R02918",
"MetaCyc:TYROSINE--TRNA-LIGASE-RXN",
"Reactome:R-HSA-379980 \"tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380170 \"tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate\"",
"RHEA:10220"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.1",
"skos:exactMatch RHEA:10220",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004832 | 4,832 | valine-tRNA ligase activity | molecular_function | Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H+. | [
"EC:6.1.1.9",
"RHEA:10704"
] | null | [
"L-valine:tRNAVal ligase (AMP-forming)",
"valine transfer ribonucleate ligase activity",
"valine translase activity",
"valyl-transfer ribonucleate synthetase activity",
"valyl-transfer ribonucleic acid synthetase activity",
"valyl-transfer RNA synthetase activity",
"valyl-tRNA synthetase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:6.1.1.9",
"KEGG_REACTION:R03665",
"MetaCyc:VALINE--TRNA-LIGASE-RXN",
"Reactome:R-HSA-380042 \"valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate\"",
"Reactome:R-HSA-380199 \"valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate\"",
"RHEA:10704"
] | [
"GO:0004812"
] | [] | [] | [] | [
"GO:0004812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.1.1.9",
"skos:exactMatch RHEA:10704",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004833 | 4,833 | L-tryptophan 2,3-dioxygenase activity | molecular_function | Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. | [
"EC:1.13.11.11"
] | null | [
"indolamine 2,3-dioxygenase activity",
"indoleamine-pyrrole 2,3-dioxygenase activity",
"L-tryptophan pyrrolase activity",
"L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)",
"TDO",
"tryptamin 2,3-dioxygenase activity",
"tryptamine 2,3-dioxygenase activity",
"tryptophan 2,3-dioxygenase activity",
... | [
"BROAD",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"BROAD",
"BROAD",
"BROAD"
] | [
"GO:0004426"
] | [] | [
"EC:1.13.11.11",
"MetaCyc:RXN-8665",
"Reactome:R-HSA-198563 \"IDO1 dioxygenates L-Trp to NFK\"",
"Reactome:R-HSA-71188 \"TDO tetramer dioxygenates L-Trp to NFK\"",
"Reactome:R-HSA-888614 \"IDO2 dioxygenates L-Trp to NFK\"",
"RHEA:24536"
] | [
"GO:0016702"
] | [] | [] | [] | [
"GO:0016702"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:1.13.11.52",
"skos:exactMatch EC:1.13.11.11",
"skos:exactMatch MetaCyc:RXN-8665",
"skos:exactMatch RHEA:24536",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30557\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30559\" x... | null | null | false | true | 8 |
GO:0004834 | 4,834 | tryptophan synthase activity | molecular_function | Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. | [
"RHEA:10532"
] | null | [
"indoleglycerol phosphate aldolase activity",
"L-serine hydro-lyase (adding indoleglycerol-phosphate)",
"L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]",
"L-tryptophan synthetase activity",
"tryptophan desmolase activity",
"tryptopha... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.2.1.20",
"KEGG_REACTION:R02722",
"MetaCyc:TRYPSYN-RXN",
"RHEA:10532"
] | [
"GO:0016836"
] | [
"part_of GO:0000162"
] | [
"part_of"
] | [
"GO:0000162"
] | [
"GO:0000162",
"GO:0016836"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.2.1.20",
"skos:exactMatch RHEA:10532",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004835 | 4,835 | tubulin-tyrosine ligase activity | molecular_function | Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate. | [
"EC:6.3.2.25"
] | null | [
"alpha-tubulin:L-tyrosine ligase (ADP-forming)",
"TTL activity",
"tubulinyl-tyrosine ligase activity"
] | [
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:6.3.2.25",
"MetaCyc:6.3.2.25-RXN",
"Reactome:R-HSA-8955706 \"TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin\"",
"RHEA:17605"
] | [
"GO:0016881",
"GO:0140096"
] | [] | [] | [] | [
"GO:0016881",
"GO:0140096"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.2.25",
"skos:exactMatch RHEA:17605",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004836 | 4,836 | tyramine-beta hydroxylase activity | molecular_function | Catalysis of the reaction: tyramine + L-ascorbate + O2 = (R)-octopamine + L-dehydroascorbate + H2O. | [
"PMID:10745161",
"RHEA:57132"
] | null | [] | [] | [] | [] | [
"MetaCyc:RXN-14645",
"RHEA:57132"
] | [
"GO:0016715"
] | [] | [] | [] | [
"GO:0016715"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch RHEA:57132",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29701\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004837 | 4,837 | tyrosine decarboxylase activity | molecular_function | Catalysis of the reaction: L-tyrosine = tyramine + CO2. | [
"EC:4.1.1.25"
] | null | [
"L-(-)-tyrosine apodecarboxylase activity",
"L-tyrosine carboxy-lyase (tyramine-forming)",
"L-tyrosine carboxy-lyase activity",
"L-tyrosine decarboxylase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.1.1.25",
"MetaCyc:TYROSINE-DECARBOXYLASE-RXN",
"RHEA:14345"
] | [
"GO:0016831"
] | [] | [] | [] | [
"GO:0016831"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.1.25",
"skos:exactMatch RHEA:14345",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004838 | 4,838 | L-tyrosine:2-oxoglutarate transaminase activity | molecular_function | Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate. | [
"RHEA:15093"
] | null | [
"glutamic phenylpyruvic aminotransferase activity",
"glutamic-hydroxyphenylpyruvic transaminase activity",
"L-phenylalanine 2-oxoglutarate aminotransferase activity",
"L-tyrosine aminotransferase activity",
"L-tyrosine transaminase activity",
"L-tyrosine-2-oxoglutarate transaminase activity",
"L-tyrosin... | [
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"BROAD"
] | [] | [] | [
"MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN",
"Reactome:R-HSA-517444 \"TAT aminates HPP\"",
"Reactome:R-HSA-71155 \"TAT deaminates tyrosine\"",
"RHEA:15093",
"UM-BBD_reactionID:r0297"
] | [
"GO:0008793"
] | [] | [] | [] | [
"GO:0008793"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:2.6.1.5",
"skos:exactMatch RHEA:15093",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28070\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31140\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004839 | 4,839 | ubiquitin activating enzyme activity | molecular_function | Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein... | [
"GOC:BioGRID",
"Wikipedia:Ubiquitin-activating_enzyme"
] | The ubiquitin activating enzyme catalyzes a ligation reaction. | [
"E1 ubiquitin-activating enzyme"
] | [
"RELATED"
] | [] | [] | [
"EC:6.2.1.45",
"Reactome:R-HSA-8852132 \"Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol\"",
"Reactome:R-HSA-8852133 \"UBA1 conjugates ubiquitin to UBA1 in the cytosol\"",
"Reactome:R-HSA-8852134 \"UBA1 adenylates ubiquitin in the cytosol\"",
"Reactome:R-HSA-8865050 \"Ub-Cys625-UBA6 adenylates ubiquitin ... | [
"GO:0008641"
] | [
"part_of GO:0016567"
] | [
"part_of"
] | [
"GO:0016567"
] | [
"GO:0008641",
"GO:0016567"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.2.1.45",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
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