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 Community
go_id
string
go_numeric_id
int64
name
string
namespace
string
definition
string
definition_xrefs
list
comment
string
synonyms
list
synonym_scopes
list
alt_ids
list
subsets
list
xrefs
list
is_a_ids
list
relationship_edges
list
relationship_types
list
relationship_target_ids
list
parent_ids
list
intersection_of
list
union_of
list
disjoint_from
list
replaced_by
list
consider
list
property_values
list
created_by
string
creation_date
string
is_obsolete
bool
in_go_basic
bool
split_bucket
int64
GO:0004842
4,842
ubiquitin-protein transferase activity
molecular_function
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
[ "GOC:BioGRID", "GOC:jh2", "PMID:9635407" ]
null
[ "E2", "E3", "ubiquitin conjugating enzyme activity", "ubiquitin ligase activity", "ubiquitin protein ligase activity", "ubiquitin protein-ligase activity", "ubiquitin-conjugating enzyme activity" ]
[ "BROAD", "BROAD", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW" ]
[ "GO:0004840", "GO:0004841" ]
[]
[ "KEGG_REACTION:R03876", "Reactome:R-HSA-1234163 \"Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha\"", "Reactome:R-HSA-1234172 \"Nuclear VBC complex ubiquitinylates HIF-alpha\"", "Reactome:R-HSA-1253282 \"ERBB4 ubiquitination by WWP1/ITCH\"", "Reactome:R-HSA-1358789 \"Self-ubiquitination of RNF...
[ "GO:0019787" ]
[]
[]
[]
[ "GO:0019787" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0004843
4,843
cysteine-type deubiquitinase activity
molecular_function
An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
[ "GOC:jh2", "PMID:30783221" ]
null
[ "deubiquitinase", "deubiquitinase activity", "deubiquitinating enzyme", "deubiquitylase", "thiol-dependent deubiquitinase", "thiol-dependent ubiquitin-specific protease activity", "thiol-dependent ubiquitinyl hydrolase activity", "ubiquitin C-terminal hydrolase", "ubiquitin hydrolase activity", "u...
[ "BROAD", "BROAD", "BROAD", "BROAD", "EXACT", "EXACT", "EXACT", "RELATED", "BROAD", "BROAD", "NARROW", "BROAD", "NARROW", "NARROW" ]
[ "GO:0036459" ]
[]
[ "EC:3.4.19.12", "Reactome:R-HSA-1358795 \"Deubiquitination of RNF41 by P-USP8\"", "Reactome:R-HSA-2179291 \"UCHL5, USP15 deubiquitinate TGFBR1\"", "Reactome:R-HSA-3215295 \"USP7 deubiquitinates MDM2\"", "Reactome:R-HSA-3215310 \"USP7 deubiquitinates TP53 and counteracts MDM2\"", "Reactome:R-HSA-3640872 \"...
[ "GO:0008234", "GO:0101005" ]
[]
[]
[]
[ "GO:0008234", "GO:0101005" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:3.4.19.12", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19723\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
null
null
false
true
7
GO:0004844
4,844
uracil DNA N-glycosylase activity
molecular_function
Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opp...
[ "GOC:elh", "GOC:pr", "PMID:9224623" ]
null
[ "uracil-DNA glycosylase activity" ]
[ "EXACT" ]
[]
[]
[ "EC:3.2.2.27", "Reactome:R-HSA-110215 \"Cleavage of uracil by UNG glycosylase\"", "Reactome:R-HSA-110217 \"Cleavage of 5-hydroxyluracil by UNG glycosylase\"", "Reactome:R-HSA-9817512 \"UNG (UNG2) and base excision repair remove uridine and 5-methylcytidine from chromatin containing histone H3.3\"" ]
[ "GO:0097506" ]
[]
[]
[]
[ "GO:0097506" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:3.2.2.27", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25051\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
null
null
false
true
2
GO:0004845
4,845
uracil phosphoribosyltransferase activity
molecular_function
Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil.
[ "EC:2.4.2.9", "RHEA:13017" ]
null
[ "UMP diphosphorylase activity", "UMP pyrophosphorylase activity", "UMP:diphosphate phospho-alpha-D-ribosyltransferase activity", "UMP:pyrophosphate phosphoribosyltransferase activity", "UPRTase activity", "uridine 5'-phosphate pyrophosphorylase activity", "uridine monophosphate pyrophosphorylase activit...
[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[ "EC:2.4.2.9", "KEGG_REACTION:R00966", "MetaCyc:URACIL-PRIBOSYLTRANS-RXN", "RHEA:13017" ]
[ "GO:0016763" ]
[]
[]
[]
[ "GO:0016763" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.4.2.9", "skos:exactMatch RHEA:13017", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
null
null
false
true
6
GO:0004846
4,846
urate oxidase activity
molecular_function
Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + H2O2.
[ "EC:1.7.3.3" ]
null
[ "urate:oxygen oxidoreductase activity", "uric acid oxidase activity", "uricase activity", "uricase II activity" ]
[ "RELATED", "RELATED", "RELATED", "NARROW" ]
[]
[]
[ "EC:1.7.3.3", "MetaCyc:URATE-OXIDASE-RXN", "RHEA:21368", "UM-BBD_reactionID:r1322" ]
[ "GO:0016663" ]
[]
[]
[]
[ "GO:0016663" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.7.3.3", "skos:exactMatch RHEA:21368", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
null
null
false
true
6
GO:0004847
4,847
urea carboxylase activity
molecular_function
Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H+ + phosphate + urea-1-carboxylate.
[ "EC:6.3.4.6", "RHEA:20896" ]
null
[ "ATP--urea amidolyase activity", "UALase activity", "UCA activity", "urea amidolyase activity", "urea carboxylase (hydrolysing)", "urea carboxylase (hydrolyzing) activity", "urea:carbon-dioxide ligase (ADP-forming)", "urease (ATP-hydrolysing)", "urease (ATP-hydrolyzing) activity" ]
[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[ "EC:6.3.4.6", "KEGG_REACTION:R00774", "MetaCyc:UREA-CARBOXYLASE-RXN", "RHEA:20896" ]
[ "GO:0016879" ]
[]
[]
[]
[ "GO:0016879" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:6.3.4.6", "skos:exactMatch RHEA:20896", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
null
null
false
true
6
GO:0004848
4,848
ureidoglycolate hydrolase activity
molecular_function
Catalysis of the reaction: (S)-ureidoglycolate + H2O + 2 H+ = CO2 + glyoxylate + 2 NH4.
[ "RHEA:19809" ]
Take care to annotate to the reaction, not simply the enzyme name. The name "ureidoglycolate hydrolase" has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase"...
[ "ureidoglycolate amidohydrolase activity" ]
[ "EXACT" ]
[]
[]
[ "EC:3.5.1.116", "KEGG_REACTION:R00469", "MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN", "RHEA:19809" ]
[ "GO:0016811" ]
[]
[]
[]
[ "GO:0016811" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:3.5.1.116", "skos:exactMatch RHEA:19809", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24927\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
null
null
false
true
4
GO:0004849
4,849
uridine kinase activity
molecular_function
Catalysis of the reaction: ATP + uridine = ADP + UMP.
[ "RHEA:16825" ]
null
[ "uridine phosphokinase activity", "uridine-cytidine kinase activity" ]
[ "EXACT", "NARROW" ]
[]
[]
[ "EC:2.7.1.48", "MetaCyc:URIDINEKIN-RXN", "Reactome:R-HSA-8954327 \"UCKL1 phosphorylates urindine, cytidine\"", "RHEA:16825" ]
[ "GO:0019206" ]
[ "part_of GO:0006222" ]
[ "part_of" ]
[ "GO:0006222" ]
[ "GO:0006222", "GO:0019206" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch RHEA:16825", "skos:narrowMatch EC:2.7.1.48", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25077\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
null
null
false
true
2
GO:0004850
4,850
uridine phosphorylase activity
molecular_function
Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.
[ "EC:2.4.2.3" ]
null
[ "pyrimidine phosphorylase activity", "UPase activity", "UPH", "UrdPase activity", "uridine:phosphate alpha-D-ribosyltransferase activity" ]
[ "BROAD", "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[ "EC:2.4.2.3", "MetaCyc:URPHOS-RXN", "Reactome:R-HSA-74372 \"uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]\"", "Reactome:R-HSA-74376 \"(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)\"", "RHEA:24388" ]
[ "GO:0016154" ]
[]
[]
[]
[ "GO:0016154" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.4.2.3", "skos:exactMatch RHEA:24388", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
null
null
false
true
9
GO:0004851
4,851
uroporphyrin-III C-methyltransferase activity
molecular_function
Catalysis of the reaction: uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H+.
[ "RHEA:32459" ]
null
[ "adenosylmethionine-uroporphyrinogen III methyltransferase activity", "CobA", "CysG", "S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity", "S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase activity", "S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase acti...
[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[ "EC:2.1.1.107", "MetaCyc:RXN-13403", "RHEA:32459" ]
[ "GO:0008169", "GO:0008757" ]
[]
[]
[]
[ "GO:0008169", "GO:0008757" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.1.1.107", "skos:exactMatch RHEA:32459", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28199\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
null
null
false
true
8
GO:0004852
4,852
uroporphyrinogen-III synthase activity
molecular_function
Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III.
[ "EC:4.2.1.75", "RHEA:18965" ]
null
[ "hydroxymethylbilane hydro-lyase (cyclizing) activity", "hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)", "porphobilinogenase activity", "URO-synthase activity", "uroporphyrinogen III cosynthase activity", "uroporphyrinogen isomerase activity", "uroporphyrinogen-III cosynthase...
[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[ "EC:4.2.1.75", "KEGG_REACTION:R03165", "MetaCyc:UROGENIIISYN-RXN", "Reactome:R-HSA-189488 \"UROS transforms HMB to URO3\"", "RHEA:18965" ]
[ "GO:0016836" ]
[]
[]
[]
[ "GO:0016836" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:4.2.1.75", "skos:exactMatch RHEA:18965", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
null
null
false
true
4
GO:0004853
4,853
uroporphyrinogen decarboxylase activity
molecular_function
Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2.
[ "EC:4.1.1.37" ]
null
[ "porphyrinogen carboxy-lyase activity", "porphyrinogen decarboxylase activity", "uroporphyrinogen III decarboxylase activity", "uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)", "uroporphyrinogen-III carboxy-lyase activity" ]
[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[ "EC:4.1.1.37", "MetaCyc:UROGENDECARBOX-RXN", "RHEA:19865" ]
[ "GO:0016831" ]
[]
[]
[]
[ "GO:0016831" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:4.1.1.37", "skos:exactMatch RHEA:19865", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
null
null
false
true
1
GO:0004854
4,854
xanthine dehydrogenase activity
molecular_function
Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.
[ "EC:1.17.1.4" ]
null
[ "NAD-xanthine dehydrogenase activity", "xanthine oxidoreductase activity", "xanthine-NAD oxidoreductase activity", "xanthine/NAD(+) oxidoreductase activity", "xanthine/NAD+ oxidoreductase activity", "xanthine:NAD+ oxidoreductase activity" ]
[ "RELATED", "BROAD", "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[ "EC:1.17.1.4", "MetaCyc:RXN0-901", "Reactome:R-HSA-9727349 \"XDH dehydrogenates xanthine to form urate\"", "RHEA:16669" ]
[ "GO:0016726" ]
[]
[]
[]
[ "GO:0016726" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.17.1.4", "skos:exactMatch RHEA:16669", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
null
null
false
true
9
GO:0004855
4,855
xanthine oxidase activity
molecular_function
Catalysis of the reaction: xanthine + H2O + O2 = urate + H2O2.
[ "EC:1.17.3.2" ]
null
[ "hypoxanthine-xanthine oxidase activity", "schardinger enzyme", "Schardinger enzyme activity", "xanthine oxidoreductase activity", "xanthine:O2 oxidoreductase activity", "xanthine:oxygen oxidoreductase activity", "xanthine:xanthine oxidase activity" ]
[ "BROAD", "RELATED", "RELATED", "BROAD", "RELATED", "RELATED", "RELATED" ]
[]
[]
[ "EC:1.17.3.2", "MetaCyc:XANTHINE-OXIDASE-RXN", "Reactome:R-HSA-74258 \"XDH oxidizes xanthine to form urate\"", "Reactome:R-HSA-9748991 \"XDH oxidises 6MP to 6TU\"", "RHEA:21132" ]
[ "GO:0016727" ]
[]
[]
[]
[ "GO:0016727" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.17.3.2", "skos:exactMatch RHEA:21132", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
null
null
false
true
5
GO:0004856
4,856
D-xylulokinase activity
molecular_function
Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H+.
[ "EC:2.7.1.17", "RHEA:10964" ]
null
[ "ATP:D-xylulose 5-phosphotransferase activity", "xylulokinase (phosphorylating)", "xylulokinase activity", "xylulose kinase activity" ]
[ "RELATED", "RELATED", "BROAD", "RELATED" ]
[]
[]
[ "EC:2.7.1.17", "KEGG_REACTION:R01639", "MetaCyc:XYLULOKIN-RXN", "Reactome:R-HSA-5662466 \"XYLB phosphorylates D-xylulose\"", "RHEA:10964" ]
[ "GO:0016773", "GO:0019200" ]
[]
[]
[]
[ "GO:0016773", "GO:0019200" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.7.1.17", "skos:exactMatch RHEA:10964", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26853\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28622\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontol...
null
null
false
true
4
GO:0004857
4,857
enzyme inhibitor activity
molecular_function
A molecular function regulator that reduces a catalytic activity.
[ "GOC:ai", "GOC:ebc" ]
This term should only be used in cases when the regulator directly interacts with the enzyme, but does not result in a covalent modification.
[ "metalloenzyme inhibitor activity" ]
[ "NARROW" ]
[ "GO:0048551" ]
[]
[ "Reactome:R-HSA-1474158 \"GCHFR binds to GCH1 and negatively regulates its activity\"", "Reactome:R-HSA-1614336 \"SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases\"" ]
[ "GO:0030234", "GO:0140678" ]
[ "negatively_regulates GO:0003824" ]
[ "negatively_regulates" ]
[ "GO:0003824" ]
[ "GO:0003824", "GO:0030234", "GO:0140678" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0004860
4,860
protein kinase inhibitor activity
molecular_function
Binds to and stops, prevents or reduces the activity of a protein kinase.
[ "GOC:ai" ]
null
[]
[]
[]
[]
[]
[ "GO:0019210", "GO:0019887" ]
[ "negatively_regulates GO:0004672" ]
[ "negatively_regulates" ]
[ "GO:0004672" ]
[ "GO:0004672", "GO:0019210", "GO:0019887" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0004861
4,861
cyclin-dependent protein serine/threonine kinase inhibitor activity
molecular_function
Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase.
[ "GOC:mah", "GOC:pr" ]
null
[ "CDK inhibitor", "cyclin dependent kinase inhibitor", "cyclin dependent protein kinase inhibitor activity", "cyclin-dependent kinase inhibitor", "cyclin-dependent protein kinase inhibitor activity" ]
[ "RELATED", "RELATED", "EXACT", "RELATED", "BROAD" ]
[]
[]
[ "Reactome:R-HSA-187934 \"Inactivation of Cyclin A:Cdk2 complexes by p27/p21\"", "Reactome:R-HSA-69562 \"Inactivation of Cyclin E:Cdk2 complexes by p27/p21\"" ]
[ "GO:0016538", "GO:0030291" ]
[ "negatively_regulates GO:0004693" ]
[ "negatively_regulates" ]
[ "GO:0004693" ]
[ "GO:0004693", "GO:0016538", "GO:0030291" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0004862
4,862
cAMP-dependent protein kinase inhibitor activity
molecular_function
Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase.
[ "GOC:mah" ]
null
[]
[]
[]
[]
[ "Reactome:R-HSA-180073 \"DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function\"" ]
[ "GO:0008603", "GO:0030291" ]
[ "negatively_regulates GO:0004691" ]
[ "negatively_regulates" ]
[ "GO:0004691" ]
[ "GO:0004691", "GO:0008603", "GO:0030291" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0004864
4,864
protein phosphatase inhibitor activity
molecular_function
Binds to and stops, prevents or reduces the activity of a protein phosphatase.
[ "GOC:ai" ]
null
[ "phosphoprotein phosphatase inhibitor activity", "protein phosphatase 2 inhibitor activity", "protein phosphatase type 2A inhibitor activity" ]
[ "EXACT", "NARROW", "NARROW" ]
[ "GO:1990681" ]
[]
[]
[ "GO:0019212", "GO:0019888" ]
[ "negatively_regulates GO:0004721" ]
[ "negatively_regulates" ]
[ "GO:0004721" ]
[ "GO:0004721", "GO:0019212", "GO:0019888" ]
[]
[]
[]
[]
[]
[]
rb
2015-03-03T23:57:25Z
false
true
6
GO:0004865
4,865
protein serine/threonine phosphatase inhibitor activity
molecular_function
Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate.
[ "GOC:dph", "GOC:tb" ]
null
[]
[]
[]
[]
[]
[ "GO:0004864" ]
[ "negatively_regulates GO:0004722" ]
[ "negatively_regulates" ]
[ "GO:0004722" ]
[ "GO:0004722", "GO:0004864" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0004866
4,866
endopeptidase inhibitor activity
molecular_function
Binds to and stops, prevents or reduces the activity of an endopeptidase.
[ "GOC:jl" ]
null
[ "alpha-2 macroglobulin", "endoproteinase inhibitor", "proteinase inhibitor" ]
[ "RELATED", "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0030414", "GO:0061135" ]
[ "negatively_regulates GO:0004175" ]
[ "negatively_regulates" ]
[ "GO:0004175" ]
[ "GO:0004175", "GO:0030414", "GO:0061135" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0004867
4,867
serine-type endopeptidase inhibitor activity
molecular_function
Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase.
[ "GOC:ai" ]
null
[ "serine protease inhibitor activity", "serine proteinase inhibitor activity", "serpin activity" ]
[ "NARROW", "NARROW", "NARROW" ]
[]
[]
[ "Reactome:R-HSA-158795 \"fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1\"", "Reactome:R-HSA-158800 \"fibrin multimer, crosslinked:tissue plasminogen...
[ "GO:0004866" ]
[ "negatively_regulates GO:0004252" ]
[ "negatively_regulates" ]
[ "GO:0004252" ]
[ "GO:0004252", "GO:0004866" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0004868
4,868
obsolete serpin
molecular_function
OBSOLETE. A superfamily of proteins, many of which inhibit serine proteinases and exhibit a high degree of homology with classical serine proteinase inhibitors such as alpha1-antitrypsin or antithrombin.
[ "GOC:ai", "ISBN:0198506732" ]
This term was made obsolete because it represents a class of gene products.
[ "serpin" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0004867" ]
[]
null
null
true
true
2
GO:0004869
4,869
cysteine-type endopeptidase inhibitor activity
molecular_function
Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase.
[ "GOC:dph", "GOC:tb" ]
null
[ "cystatin", "cysteine protease inhibitor activity", "thiol protease inhibitor" ]
[ "NARROW", "NARROW", "NARROW" ]
[ "GO:0004870" ]
[]
[]
[ "GO:0004866" ]
[ "negatively_regulates GO:0004197" ]
[ "negatively_regulates" ]
[ "GO:0004197" ]
[ "GO:0004197", "GO:0004866" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0004871
4,871
obsolete signal transducer activity
molecular_function
OBSOLETE. Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
[ "GOC:curators" ]
This term was obsoleted because it was not clearly defined and is not a useful grouping term.
[ "hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity", "quorum sensing response regulator activity", "quorum sensing signal generator activity" ]
[ "NARROW", "NARROW", "NARROW" ]
[ "GO:0005062", "GO:0009369", "GO:0009370" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14232\" xsd:anyURI" ]
null
null
true
true
1
GO:0004873
4,873
asialoglycoprotein receptor activity
molecular_function
Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N...
[ "GOC:bf", "PMID:11278827", "PMID:7624395", "Wikipedia:Asialoglycoprotein" ]
null
[]
[]
[]
[ "goslim_chembl" ]
[]
[ "GO:0038024" ]
[]
[]
[]
[ "GO:0038024" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0004874
4,874
obsolete aryl hydrocarbon receptor activity
molecular_function
OBSOLETE. Combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding.
[ "GOC:ai", "PMID:1325649", "PMID:7493958", "Wikipedia:Aryl_hydrocarbon_receptor" ]
This term was obsoleted because it represents a gene product.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/16732\" xsd:anyURI" ]
null
null
true
true
5
GO:0004875
4,875
complement receptor activity
molecular_function
Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:add", "GOC:ai", "GOC:pg", "GOC:signaling", "ISBN:0781735149", "PMID:11884446" ]
Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways.
[ "anaphylatoxin receptor activity" ]
[ "RELATED" ]
[ "GO:0004942" ]
[]
[]
[ "GO:0004888", "GO:0140375" ]
[ "has_part GO:0001848", "part_of GO:0002430" ]
[ "has_part", "part_of" ]
[ "GO:0001848", "GO:0002430" ]
[ "GO:0001848", "GO:0002430", "GO:0004888", "GO:0140375" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0004876
4,876
complement component C3a receptor activity
molecular_function
Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:add", "GOC:mah", "GOC:pg", "GOC:signaling", "ISBN:0781735149" ]
null
[ "C3a anaphylatoxin receptor activity" ]
[ "RELATED" ]
[ "GO:0004943" ]
[]
[]
[ "GO:0004875" ]
[]
[]
[]
[ "GO:0004875" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0004877
4,877
complement component C3b receptor activity
molecular_function
Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:add", "GOC:signaling", "ISBN:0781735149" ]
null
[]
[]
[]
[]
[]
[ "GO:0001847", "GO:0004875" ]
[ "has_part GO:0001850", "has_part GO:0001851" ]
[ "has_part", "has_part" ]
[ "GO:0001850", "GO:0001851" ]
[ "GO:0001847", "GO:0001850", "GO:0001851", "GO:0004875" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0004878
4,878
complement component C5a receptor activity
molecular_function
Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:add", "GOC:mah", "GOC:pg", "GOC:signaling", "ISBN:0781735149" ]
null
[ "C5a anaphylatoxin receptor activity" ]
[ "RELATED" ]
[ "GO:0004944" ]
[]
[]
[ "GO:0001847", "GO:0004875" ]
[ "has_part GO:0001856", "part_of GO:0038178" ]
[ "has_part", "part_of" ]
[ "GO:0001856", "GO:0038178" ]
[ "GO:0001847", "GO:0001856", "GO:0004875", "GO:0038178" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0004879
4,879
nuclear receptor activity
molecular_function
A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, wh...
[ "GOC:txnOH-2018", "PMID:23457262" ]
Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate t...
[ "1,25-(OH)2D3 receptor activity", "9-cis retinoic acid receptor activity", "androgen receptor activity", "calcitriol receptor activity", "ecdysteroid hormone receptor activity", "estrogen nuclear receptor activity", "glucocorticoid receptor activity", "juvenile hormone receptor activity", "ligand-ac...
[ "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "EXACT", "RELATED", "RELATED", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "EXACT", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW" ]
[ "GO:0003708", "GO:0004880", "GO:0004882", "GO:0004884", "GO:0004886", "GO:0004887", "GO:0008434", "GO:0038050", "GO:0038051", "GO:0038052" ]
[]
[ "Reactome:R-HSA-400143 \"Fatty acid ligands activate PPARA\"", "Reactome:R-HSA-8936849 \"AHR:2xHSP90:AIP:PTGES3 binds TCDD\"", "Reactome:R-HSA-8937169 \"AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm\"", "Reactome:R-HSA-8937191 \"AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates\"" ]
[ "GO:0000981", "GO:0038023", "GO:0098531" ]
[ "part_of GO:0030522" ]
[ "part_of" ]
[ "GO:0030522" ]
[ "GO:0000981", "GO:0030522", "GO:0038023", "GO:0098531" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19518\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20253\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29150\" xsd:anyURI" ]
null
null
false
true
5
GO:0004883
4,883
nuclear glucocorticoid receptor activity
molecular_function
A nuclear receptor activity regulated by glucocorticoid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II.
[ "GOC:signaling", "PMID:17689856", "PMID:20920967" ]
null
[ "glucocorticoid receptor activity" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0003707" ]
[ "part_of GO:0042921" ]
[ "part_of" ]
[ "GO:0042921" ]
[ "GO:0003707", "GO:0042921" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/16717\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29150\" xsd:anyURI" ]
null
null
false
true
3
GO:0004888
4,888
transmembrane signaling receptor activity
molecular_function
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
[ "GOC:curators", "Wikipedia:Transmembrane_receptor" ]
This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores.
[ "transmembrane receptor activity", "transmembrane signalling receptor activity" ]
[ "BROAD", "EXACT" ]
[ "GO:0004926", "GO:0099600" ]
[]
[ "Reactome:R-HSA-193672 \"Sphingomyelinase is activated by the NGF:p75NTR complex\"" ]
[ "GO:0038023" ]
[]
[]
[]
[ "GO:0038023" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0004890
4,890
GABA-A receptor activity
molecular_function
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.
[ "PMID:8974333" ]
Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'chloride channel activity ; GO:0005254' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'.
[ "ionotropic GABA receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0016917" ]
[]
[]
[]
[ "GO:0016917" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0004895
4,895
cell adhesion receptor activity
molecular_function
The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins.
[ "GOC:BHF-UCL", "Wikipedia:Cell_adhesion" ]
Reinstated term from obsolete.
[]
[]
[]
[]
[]
[ "GO:0038023", "GO:0098631" ]
[]
[]
[]
[ "GO:0038023", "GO:0098631" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15237\" xsd:anyURI" ]
null
null
false
true
5
GO:0004896
4,896
cytokine receptor activity
molecular_function
Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:add", "GOC:mah" ]
null
[ "hematopoietin/interferon-class (D200-domain) cytokine receptor activity", "IL receptor", "interleukin receptor activity" ]
[ "RELATED", "NARROW", "NARROW" ]
[ "GO:0004907" ]
[]
[]
[ "GO:0004888", "GO:0140375" ]
[ "has_part GO:0019955", "part_of GO:0019221" ]
[ "has_part", "part_of" ]
[ "GO:0019955", "GO:0019221" ]
[ "GO:0004888", "GO:0019221", "GO:0019955", "GO:0140375" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0004898
4,898
obsolete gp130
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:jl" ]
This term was made obsolete because it represents a gene product.
[ "gp130" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0004897", "GO:0004915", "GO:0004921" ]
[]
null
null
true
true
4
GO:0004900
4,900
erythropoietin receptor activity
molecular_function
Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:ai", "GOC:signaling" ]
null
[]
[]
[]
[]
[]
[ "GO:0004896" ]
[ "part_of GO:0038162" ]
[ "part_of" ]
[ "GO:0038162" ]
[ "GO:0004896", "GO:0038162" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0004901
4,901
granulocyte macrophage colony-stimulating factor receptor activity
molecular_function
Combining with granulocyte macrophage colony-stimulating factor (GM-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:mah", "GOC:signaling" ]
null
[ "CSF-2 receptor activity", "CSF2R", "GM-CSF receptor activity", "GMC-SF receptor activity", "granulocyte macrophage colony stimulating factor receptor activity" ]
[ "EXACT", "RELATED", "EXACT", "EXACT", "EXACT" ]
[ "GO:0030525" ]
[]
[]
[ "GO:0004896" ]
[ "has_part GO:0042021", "part_of GO:0038157" ]
[ "has_part", "part_of" ]
[ "GO:0042021", "GO:0038157" ]
[ "GO:0004896", "GO:0038157", "GO:0042021" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0004902
4,902
granulocyte colony-stimulating factor receptor activity
molecular_function
Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:mah", "GOC:signaling" ]
null
[ "CSF3R", "G-CSF receptor activity", "granulocyte colony stimulating factor receptor activity" ]
[ "RELATED", "EXACT", "EXACT" ]
[ "GO:0030524" ]
[]
[]
[ "GO:0004896" ]
[ "has_part GO:0051916", "part_of GO:0038158" ]
[ "has_part", "part_of" ]
[ "GO:0051916", "GO:0038158" ]
[ "GO:0004896", "GO:0038158", "GO:0051916" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0004903
4,903
growth hormone receptor activity
molecular_function
Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:ai", "GOC:signaling" ]
null
[]
[]
[]
[]
[]
[ "GO:0004896" ]
[]
[]
[]
[ "GO:0004896" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0004904
4,904
interferon receptor activity
molecular_function
Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:ai", "GOC:signaling", "PMID:9607096" ]
null
[ "IFN receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0004896" ]
[ "has_part GO:0019961" ]
[ "has_part" ]
[ "GO:0019961" ]
[ "GO:0004896", "GO:0019961" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0004905
4,905
type I interferon receptor activity
molecular_function
Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.
[ "GOC:add", "GOC:signaling", "ISBN:0126896631", "PMID:15546383", "PMID:16681834" ]
null
[ "interferon-alpha receptor activity", "interferon-alpha/beta receptor activity", "interferon-beta receptor activity", "interferon-delta receptor activity", "interferon-epsilon receptor activity", "interferon-kappa receptor activity", "interferon-omega receptor activity", "interferon-tau receptor activ...
[ "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "EXACT" ]
[]
[]
[]
[ "GO:0004904" ]
[ "has_part GO:0019962", "part_of GO:0060337" ]
[ "has_part", "part_of" ]
[ "GO:0019962", "GO:0060337" ]
[ "GO:0004904", "GO:0019962", "GO:0060337" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0004906
4,906
type II interferon receptor activity
molecular_function
Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:add", "GOC:ai", "GOC:signaling", "ISBN:0126896631", "PMID:15546383" ]
null
[ "IFN-gamma receptor activity", "IFNG receptor activity", "interferon-gamma receptor activity" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004904" ]
[ "has_part GO:0019964", "part_of GO:0060333" ]
[ "has_part", "part_of" ]
[ "GO:0019964", "GO:0060333" ]
[ "GO:0004904", "GO:0019964", "GO:0060333" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0004908
4,908
interleukin-1 receptor activity
molecular_function
Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.
[ "GOC:jl" ]
null
[ "IL-1 receptor activity", "IL-1R" ]
[ "EXACT", "EXACT" ]
[]
[]
[ "Wikipedia:Interleukin-1_receptor" ]
[ "GO:0004896" ]
[ "has_part GO:0019966" ]
[ "has_part" ]
[ "GO:0019966" ]
[ "GO:0004896", "GO:0019966" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0004909
4,909
interleukin-1, type I, activating receptor activity
molecular_function
Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins.
[ "PMID:15062641", "PMID:18613828" ]
null
[ "IL-1 type I, activating binding", "IL-1 type I, activating receptor", "interleukin-1 activating receptor activity", "interleukin-1 type I receptor activity", "interleukin-1, type I, activating binding" ]
[ "EXACT", "EXACT", "EXACT", "EXACT", "RELATED" ]
[ "GO:0019967" ]
[]
[]
[ "GO:0004908" ]
[ "part_of GO:0070498" ]
[ "part_of" ]
[ "GO:0070498" ]
[ "GO:0004908", "GO:0070498" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0004910
4,910
interleukin-1, type II, blocking receptor activity
molecular_function
Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors.
[ "PMID:15062641", "PMID:18613828" ]
null
[ "IL-1 type II, blocking binding", "IL-1 type II, blocking receptor", "interleukin-1 blocking receptor activity", "interleukin-1 type II receptor activity", "interleukin-1, type II, blocking binding" ]
[ "EXACT", "EXACT", "EXACT", "EXACT", "RELATED" ]
[ "GO:0019968" ]
[]
[]
[ "GO:0004908" ]
[]
[]
[]
[ "GO:0004908" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0004912
4,912
interleukin-3 receptor activity
molecular_function
Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:jl", "GOC:signaling" ]
null
[ "IL-3 receptor activity", "IL-3R" ]
[ "EXACT", "EXACT" ]
[]
[]
[ "Wikipedia:Interleukin-3_receptor" ]
[ "GO:0004896" ]
[ "has_part GO:0019978", "part_of GO:0036016", "part_of GO:0038156" ]
[ "has_part", "part_of", "part_of" ]
[ "GO:0019978", "GO:0036016", "GO:0038156" ]
[ "GO:0004896", "GO:0019978", "GO:0036016", "GO:0038156" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0004913
4,913
interleukin-4 receptor activity
molecular_function
Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:jl", "GOC:signaling" ]
null
[ "IL-4 receptor activity", "IL-4R" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004896" ]
[ "has_part GO:0019979", "part_of GO:0035771" ]
[ "has_part", "part_of" ]
[ "GO:0019979", "GO:0035771" ]
[ "GO:0004896", "GO:0019979", "GO:0035771" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0004915
4,915
interleukin-6 receptor activity
molecular_function
Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:jl", "GOC:signaling" ]
null
[ "gp130", "IL-6 receptor activity", "IL-6R" ]
[ "RELATED", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004896" ]
[ "has_part GO:0019981", "part_of GO:0070102" ]
[ "has_part", "part_of" ]
[ "GO:0019981", "GO:0070102" ]
[ "GO:0004896", "GO:0019981", "GO:0070102" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0004917
4,917
interleukin-7 receptor activity
molecular_function
Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:jl", "GOC:signaling" ]
null
[ "IL-7 receptor activity", "IL-7R" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004896" ]
[ "has_part GO:0019982", "part_of GO:0038111" ]
[ "has_part", "part_of" ]
[ "GO:0019982", "GO:0038111" ]
[ "GO:0004896", "GO:0019982", "GO:0038111" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0004918
4,918
interleukin-8 receptor activity
molecular_function
Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:jl", "GOC:signaling" ]
null
[ "IL-8 receptor activity", "IL-8R" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0016494" ]
[ "has_part GO:0019959", "part_of GO:0038112" ]
[ "has_part", "part_of" ]
[ "GO:0019959", "GO:0038112" ]
[ "GO:0016494", "GO:0019959", "GO:0038112" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0004919
4,919
interleukin-9 receptor activity
molecular_function
Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:jl", "GOC:signaling" ]
null
[ "IL-9 receptor activity", "IL-9R" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004896" ]
[ "has_part GO:0019983", "part_of GO:0038113" ]
[ "has_part", "part_of" ]
[ "GO:0019983", "GO:0038113" ]
[ "GO:0004896", "GO:0019983", "GO:0038113" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0004920
4,920
interleukin-10 receptor activity
molecular_function
Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:jl", "GOC:signaling" ]
null
[ "IL-10 receptor activity", "IL-10R" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004896" ]
[ "has_part GO:0019969" ]
[ "has_part" ]
[ "GO:0019969" ]
[ "GO:0004896", "GO:0019969" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0004921
4,921
interleukin-11 receptor activity
molecular_function
Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:jl", "GOC:signaling" ]
null
[ "gp130", "IL-11 receptor activity", "IL-11R" ]
[ "RELATED", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004896" ]
[ "has_part GO:0019970", "part_of GO:0038154" ]
[ "has_part", "part_of" ]
[ "GO:0019970", "GO:0038154" ]
[ "GO:0004896", "GO:0019970", "GO:0038154" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0004923
4,923
leukemia inhibitory factor receptor activity
molecular_function
Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:bf", "GOC:mah", "GOC:signaling" ]
null
[ "leukemia inhibitory factor receptor beta-protein activity", "LIF receptor activity" ]
[ "NARROW", "EXACT" ]
[ "GO:0004899" ]
[]
[]
[ "GO:0004897" ]
[ "part_of GO:0048861" ]
[ "part_of" ]
[ "GO:0048861" ]
[ "GO:0004897", "GO:0048861" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0004924
4,924
oncostatin-M receptor activity
molecular_function
Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:mah", "GOC:signaling" ]
null
[]
[]
[]
[]
[]
[ "GO:0004896" ]
[ "part_of GO:0038165" ]
[ "part_of" ]
[ "GO:0038165" ]
[ "GO:0004896", "GO:0038165" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0004925
4,925
prolactin receptor activity
molecular_function
Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:mah", "GOC:signaling" ]
null
[]
[]
[]
[]
[]
[ "GO:0004896" ]
[ "part_of GO:0038161" ]
[ "part_of" ]
[ "GO:0038161" ]
[ "GO:0004896", "GO:0038161" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0004927
4,927
obsolete sevenless receptor activity
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:jl" ]
This term was made obsolete because it represents a gene product rather than an activity.
[ "sevenless receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0004714", "GO:0004888", "GO:0008288" ]
[]
null
null
true
true
7
GO:0004928
4,928
obsolete frizzled receptor activity
molecular_function
OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity.
[ "GOC:curators" ]
This term was made obsolete because it represents a gene product rather than an activity.
[ "frizzled receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0042813" ]
[]
[]
null
null
true
true
4
GO:0004929
4,929
obsolete frizzled-2 receptor activity
molecular_function
OBSOLETE. Combining with to a member of the Wnt-family of signaling molecules to initiate a change in cell activity.
[ "GOC:curators" ]
This term was made obsolete because it represents a gene product rather than an activity.
[ "frizzled-2 receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0042813" ]
[]
[]
null
null
true
true
3
GO:0004930
4,930
G protein-coupled receptor activity
molecular_function
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
[ "GOC:bf", "Wikipedia:GPCR" ]
null
[ "EBV-induced receptor", "Epstein-Barr Virus-induced receptor activity", "G protein coupled receptor activity", "G protein linked receptor activity", "G-protein coupled receptor activity", "G-protein coupled receptor activity, unknown ligand", "G-protein linked receptor activity", "GPCR activity", "l...
[ "NARROW", "NARROW", "EXACT", "EXACT", "EXACT", "NARROW", "EXACT", "EXACT", "EXACT", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "EXACT", "NARROW", "NARROW" ]
[ "GO:0001622", "GO:0001623", "GO:0001624", "GO:0001625", "GO:0016526" ]
[ "goslim_chembl" ]
[ "Reactome:R-HSA-114552 \"Thrombin-activated PARs activate G12/13\"", "Reactome:R-HSA-114558 \"Thrombin-activated PARs activate Gq\"", "Reactome:R-HSA-167408 \"The high affinity receptor complex binds to G-protein\"", "Reactome:R-HSA-381706 \"GLP1R:GLP1 activates G(s)\"", "Wikipedia:GPCR" ]
[ "GO:0004888" ]
[ "part_of GO:0007186" ]
[ "part_of" ]
[ "GO:0007186" ]
[ "GO:0004888", "GO:0007186" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0004931
4,931
extracellularly ATP-gated monoatomic cation channel activity
molecular_function
Enables the transmembrane transfer of a monoatomic cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
[ "GOC:bf", "GOC:mah", "PMID:9755289" ]
Note that this term refers to an activity and not a gene product. Consider also annotating to the molecular function term 'purinergic nucleotide receptor activity ; GO:0001614'.
[ "extracellularly ATP-gated cation channel activity", "P2X receptor", "purinoceptor", "purinoreceptor" ]
[ "BROAD", "RELATED", "BROAD", "BROAD" ]
[]
[]
[ "Reactome:R-HSA-877187 \"P2X7 mediates loss of intracellular K+\"", "Reactome:R-HSA-9905964 \"P2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol\"" ]
[ "GO:0005231", "GO:0035381", "GO:0099094" ]
[]
[]
[]
[ "GO:0005231", "GO:0035381", "GO:0099094" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0004932
4,932
mating-type factor pheromone receptor activity
molecular_function
Combining with a mating-type factor pheromone to initiate a change in cell activity.
[ "GOC:dph", "GOC:vw" ]
null
[]
[]
[]
[]
[]
[ "GO:0008528", "GO:0016503" ]
[]
[]
[]
[ "GO:0008528", "GO:0016503" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0004933
4,933
mating-type a-factor pheromone receptor activity
molecular_function
Combining with the mating-type a-factor pheromone to initiate a change in cell activity.
[ "GOC:mah" ]
null
[ "class D G protein coupled receptor activity", "class D G-protein coupled receptor activity", "class D G-protein-coupled receptor activity", "class D GPCR activity" ]
[ "BROAD", "BROAD", "BROAD", "BROAD" ]
[]
[]
[]
[ "GO:0004932", "GO:0036318" ]
[]
[]
[]
[ "GO:0004932", "GO:0036318" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0004934
4,934
mating-type alpha-factor pheromone receptor activity
molecular_function
Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity.
[ "GOC:mah" ]
null
[ "class D G protein coupled receptor activity", "class D G-protein coupled receptor activity", "class D G-protein-coupled receptor activity", "class D GPCR activity" ]
[ "BROAD", "BROAD", "BROAD", "BROAD" ]
[]
[]
[]
[ "GO:0004932", "GO:0036318" ]
[]
[]
[]
[ "GO:0004932", "GO:0036318" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0004935
4,935
adrenergic receptor activity
molecular_function
Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex.
[ "GOC:bf", "GOC:mah", "IUPHAR_GPCR:1274" ]
null
[ "adrenoceptor activity" ]
[ "EXACT" ]
[]
[]
[ "Wikipedia:Adrenergic_receptor" ]
[ "GO:0008227" ]
[ "part_of GO:0071875" ]
[ "part_of" ]
[ "GO:0071875" ]
[ "GO:0008227", "GO:0071875" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0004936
4,936
alpha-adrenergic receptor activity
molecular_function
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors.
[ "GOC:mah", "IUPHAR_GPCR:1274" ]
null
[ "alpha adrenoceptor" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0004935" ]
[]
[]
[]
[ "GO:0004935" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0004937
4,937
alpha1-adrenergic receptor activity
molecular_function
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.
[ "GOC:cb", "GOC:mah", "IUPHAR_GPCR:1274" ]
null
[ "alpha1 adrenoceptor" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0004936" ]
[]
[]
[]
[ "GO:0004936" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0004938
4,938
alpha2-adrenergic receptor activity
molecular_function
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein.
[ "GOC:cb", "GOC:mah", "IUPHAR_GPCR:1274" ]
null
[ "alpha2 adrenoceptor" ]
[ "EXACT" ]
[]
[]
[ "Reactome:R-HSA-400071 \"Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline\"" ]
[ "GO:0004936" ]
[]
[]
[]
[ "GO:0004936" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0004939
4,939
beta-adrenergic receptor activity
molecular_function
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein.
[ "GOC:cb", "GOC:mah", "IUPHAR_GPCR:1274" ]
null
[ "beta adrenoceptor" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0004935" ]
[]
[]
[]
[ "GO:0004935" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0004940
4,940
beta1-adrenergic receptor activity
molecular_function
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors.
[ "GOC:mah", "IUPHAR_GPCR:1274" ]
null
[ "beta1 adrenoceptor" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0004939" ]
[]
[]
[]
[ "GO:0004939" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0004941
4,941
beta2-adrenergic receptor activity
molecular_function
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors.
[ "GOC:mah", "IUPHAR_GPCR:1274" ]
null
[ "beta2 adrenoceptor" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0004939" ]
[]
[]
[]
[ "GO:0004939" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0004945
4,945
angiotensin type II receptor activity
molecular_function
An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms.
[ "GOC:mah", "PMID:10977869" ]
null
[]
[]
[]
[]
[]
[ "GO:0001595" ]
[]
[]
[]
[ "GO:0001595" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0004946
4,946
bombesin receptor activity
molecular_function
Combining with bombesin to initiate a change in cell activity.
[ "GOC:ai" ]
null
[]
[]
[]
[]
[]
[ "GO:0008188" ]
[ "part_of GO:0031989" ]
[ "part_of" ]
[ "GO:0031989" ]
[ "GO:0008188", "GO:0031989" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0004948
4,948
calcitonin receptor activity
molecular_function
Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
[ "GOC:mah", "GOC:signaling", "PMID:21649645" ]
null
[]
[]
[]
[]
[]
[ "GO:0097642" ]
[ "has_part GO:0032841" ]
[ "has_part" ]
[ "GO:0032841" ]
[ "GO:0032841", "GO:0097642" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0004949
4,949
cannabinoid receptor activity
molecular_function
Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids.
[ "GOC:dph", "IUPHAR_GPCR:1279", "Wikipedia:Cannabinoid" ]
null
[ "cannaboid receptor", "endocannabinoid receptor activity" ]
[ "EXACT", "NARROW" ]
[]
[]
[]
[ "GO:0004930" ]
[ "part_of GO:0038171" ]
[ "part_of" ]
[ "GO:0038171" ]
[ "GO:0004930", "GO:0038171" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0004950
4,950
chemokine receptor activity
molecular_function
Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a nu...
[ "GOC:BHF", "GOC:rl", "GOC:signaling", "IUPHAR_GPCR:1280", "PMID:12183377", "PMID:8662823", "Wikipedia:Chemokine" ]
null
[]
[]
[]
[]
[]
[ "GO:0001637", "GO:0004896" ]
[ "has_part GO:0019956", "part_of GO:0070098" ]
[ "has_part", "part_of" ]
[ "GO:0019956", "GO:0070098" ]
[ "GO:0001637", "GO:0004896", "GO:0019956", "GO:0070098" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0004952
4,952
dopamine neurotransmitter receptor activity
molecular_function
Combining with the neurotransmitter dopamine to initiate a change in cell activity.
[ "GOC:PARL", "IUPHAR_GPCR:1282", "PMID:21711983" ]
null
[]
[]
[]
[]
[]
[ "GO:0098960" ]
[ "has_part GO:0035240", "part_of GO:0001963", "part_of GO:0007212" ]
[ "has_part", "part_of", "part_of" ]
[ "GO:0035240", "GO:0001963", "GO:0007212" ]
[ "GO:0001963", "GO:0007212", "GO:0035240", "GO:0098960" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0004953
4,953
icosanoid receptor activity
molecular_function
Combining with an icosanoid to initiate a change in cell activity.
[ "GOC:dph" ]
null
[ "eicosanoid receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0004930" ]
[ "has_part GO:0050542" ]
[ "has_part" ]
[ "GO:0050542" ]
[ "GO:0004930", "GO:0050542" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0004954
4,954
prostanoid receptor activity
molecular_function
Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity.
[ "ISBN:0198506732" ]
null
[]
[]
[]
[]
[]
[ "GO:0004953" ]
[]
[]
[]
[ "GO:0004953" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0004955
4,955
prostaglandin receptor activity
molecular_function
Combining with a prostaglandin (PG) to initiate a change in cell activity.
[ "ISBN:0198506732" ]
null
[]
[]
[]
[]
[]
[ "GO:0004954" ]
[]
[]
[]
[ "GO:0004954" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0004956
4,956
prostaglandin D receptor activity
molecular_function
Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity.
[ "ISBN:0198506732" ]
null
[ "PGD receptor activity", "PGD(2) receptor activity" ]
[ "RELATED", "EXACT" ]
[]
[]
[]
[ "GO:0004955" ]
[]
[]
[]
[ "GO:0004955" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0004957
4,957
prostaglandin E receptor activity
molecular_function
Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.
[ "ISBN:0198506732" ]
null
[ "PGE receptor activity", "PGE(2) receptor activity" ]
[ "RELATED", "EXACT" ]
[]
[]
[]
[ "GO:0004955" ]
[]
[]
[]
[ "GO:0004955" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0004958
4,958
prostaglandin F receptor activity
molecular_function
Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity.
[ "ISBN:0198506732" ]
null
[ "PGF receptor activity", "PGF(2-alpha) receptor activity" ]
[ "RELATED", "EXACT" ]
[]
[]
[]
[ "GO:0004955" ]
[]
[]
[]
[ "GO:0004955" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0004960
4,960
thromboxane receptor activity
molecular_function
Combining with a thromboxane (TXA) to initiate a change in cell activity.
[ "ISBN:0198506732" ]
null
[ "TXA receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0004954" ]
[]
[]
[]
[ "GO:0004954" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0004961
4,961
thromboxane A2 receptor activity
molecular_function
Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein.
[ "GOC:signaling", "ISBN:0198506732" ]
null
[ "TXA(2) receptor activity", "TXA2 receptor activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004960" ]
[ "part_of GO:0038193" ]
[ "part_of" ]
[ "GO:0038193" ]
[ "GO:0004960", "GO:0038193" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0004962
4,962
endothelin receptor activity
molecular_function
Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
[ "GOC:bf", "GOC:dph", "GOC:signaling", "IUPHAR_GPCR:1283", "IUPHAR_RECEPTOR:2263", "IUPHAR_RECEPTOR:2265" ]
null
[ "endothelin-A receptor activity", "endothelin-B receptor activity" ]
[ "NARROW", "NARROW" ]
[ "GO:0001599", "GO:0001600" ]
[]
[]
[ "GO:0008528" ]
[ "part_of GO:0086100" ]
[ "part_of" ]
[ "GO:0086100" ]
[ "GO:0008528", "GO:0086100" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0004963
4,963
follicle-stimulating hormone receptor activity
molecular_function
Combining with follicle-stimulating hormone to initiate a change in cell activity.
[ "GOC:mah" ]
null
[ "follicle stimulating hormone receptor activity", "FSH receptor activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0016500" ]
[ "part_of GO:0042699" ]
[ "part_of" ]
[ "GO:0042699" ]
[ "GO:0016500", "GO:0042699" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0004964
4,964
luteinizing hormone receptor activity
molecular_function
Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity.
[ "ISBN:0198506732", "PMID:18848524", "PMID:1922095" ]
null
[ "LH receptor", "LHR", "lutropin receptor", "lutropin-choriogonadotropic hormone receptor" ]
[ "EXACT", "EXACT", "EXACT", "RELATED" ]
[ "GO:0004976" ]
[]
[]
[ "GO:0004930", "GO:0016500" ]
[ "part_of GO:0042700" ]
[ "part_of" ]
[ "GO:0042700" ]
[ "GO:0004930", "GO:0016500", "GO:0042700" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0004965
4,965
G protein-coupled GABA receptor activity
molecular_function
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
[ "GOC:ai", "GOC:bf", "IUPHAR_RECEPTOR:1276", "Wikipedia:GABAB_receptor" ]
null
[ "G-protein coupled GABA receptor activity", "GABA-B receptor activity", "metabotropic GABA receptor" ]
[ "EXACT", "RELATED", "RELATED" ]
[]
[]
[ "Reactome:R-HSA-1013012 \"Binding of Gbeta/gamma to GIRK/Kir3 channels\"", "Reactome:R-HSA-1013013 \"Association of GABA B receptor with G protein beta-gamma subunits\"" ]
[ "GO:0004930", "GO:0016917" ]
[]
[]
[]
[ "GO:0004930", "GO:0016917" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0004966
4,966
galanin receptor activity
molecular_function
Combining with galanin to initiate a change in cell activity.
[ "GOC:ai" ]
null
[]
[]
[]
[]
[]
[ "GO:0008188" ]
[]
[]
[]
[ "GO:0008188" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0004967
4,967
glucagon receptor activity
molecular_function
Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
[ "GOC:mah", "GOC:signaling", "PMID:22438981" ]
null
[]
[]
[]
[]
[ "Reactome:R-HSA-163625 \"Glucagon binds to Glucagon receptor\"" ]
[ "GO:0008528" ]
[ "part_of GO:0071377" ]
[ "part_of" ]
[ "GO:0071377" ]
[ "GO:0008528", "GO:0071377" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0004968
4,968
gonadotropin-releasing hormone receptor activity
molecular_function
Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus...
[ "GOC:mah" ]
null
[ "GnRH receptor activity", "gonadotrophin-releasing hormone receptor activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004930", "GO:0016500" ]
[ "has_part GO:0051448", "part_of GO:0097211" ]
[ "has_part", "part_of" ]
[ "GO:0051448", "GO:0097211" ]
[ "GO:0004930", "GO:0016500", "GO:0051448", "GO:0097211" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0004969
4,969
histamine receptor activity
molecular_function
Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
[ "GOC:ai" ]
null
[]
[]
[]
[]
[]
[ "GO:0008227" ]
[ "has_part GO:0051381" ]
[ "has_part" ]
[ "GO:0051381" ]
[ "GO:0008227", "GO:0051381" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0004970
4,970
glutamate-gated receptor activity
molecular_function
Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.
[ "ISBN:0198506732" ]
Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'glutamate-gated ion channel activity ; GO:0005234' and 'cation channel activity ; GO:0005261'.
[ "ionotropic glutamate receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0008066", "GO:0015171", "GO:0022824", "GO:0046943" ]
[ "part_of GO:0035235" ]
[ "part_of" ]
[ "GO:0035235" ]
[ "GO:0008066", "GO:0015171", "GO:0022824", "GO:0035235", "GO:0046943" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0004971
4,971
AMPA glutamate receptor activity
molecular_function
An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium.
[ "GOC:mah", "PMID:10049997", "PMID:8804111" ]
Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'.
[ "alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity", "AMPA receptor activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004970" ]
[]
[]
[]
[ "GO:0004970" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0004972
4,972
NMDA glutamate receptor activity
molecular_function
A cation channel that opens in response to binding by extracellular glutmate, but only if glycine or D-serine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages.
[ "GOC:mah", "PMID:10049997", "PMID:7790891" ]
The name of this receptor comes from its selective activation by N-methyl-D-aspartate (NMDA). Note that this term represents an activity and not a gene product.
[ "N-methyl-D-aspartate selective glutamate receptor activity", "NMDA receptor" ]
[ "EXACT", "EXACT" ]
[]
[]
[ "Wikipedia:NMDA_receptor" ]
[ "GO:0004970", "GO:0005244" ]
[]
[]
[]
[ "GO:0004970", "GO:0005244" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9