Datasets:
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GO

Dataset card Data Studio Files
xet
 Community
go_id
string
go_numeric_id
int64
name
string
namespace
string
definition
string
definition_xrefs
list
comment
string
synonyms
list
synonym_scopes
list
alt_ids
list
subsets
list
xrefs
list
is_a_ids
list
relationship_edges
list
relationship_types
list
relationship_target_ids
list
parent_ids
list
intersection_of
list
union_of
list
disjoint_from
list
replaced_by
list
consider
list
property_values
list
created_by
string
creation_date
string
is_obsolete
bool
in_go_basic
bool
split_bucket
int64
GO:0004973
4,973
obsolete N-methyl-D-aspartate receptor-associated protein activity
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:ai" ]
This term was made obsolete because it represents a gene product and not a molecular function.
[ "N-methyl-D-aspartate receptor-associated protein activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0005102", "GO:0005515" ]
[]
null
null
true
true
5
GO:0004974
4,974
leukotriene receptor activity
molecular_function
Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine.
[ "GOC:ai", "ISBN:0198506732" ]
null
[]
[]
[]
[]
[]
[ "GO:0004953" ]
[ "part_of GO:0061737" ]
[ "part_of" ]
[ "GO:0061737" ]
[ "GO:0004953", "GO:0061737" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0004977
4,977
melanocortin receptor activity
molecular_function
Combining with melanocortin to initiate a change in cell activity.
[ "GOC:ai" ]
null
[]
[]
[]
[]
[]
[ "GO:0008528" ]
[]
[]
[]
[ "GO:0008528" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0004978
4,978
corticotropin receptor activity
molecular_function
Combining with corticotropin to initiate a change in cell activity.
[ "GOC:ai" ]
null
[ "ACTH receptor activity", "adrenocorticotropic hormone receptor activity", "adrenocorticotropin receptor activity" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004977", "GO:0008188" ]
[ "has_part GO:0042562" ]
[ "has_part" ]
[ "GO:0042562" ]
[ "GO:0004977", "GO:0008188", "GO:0042562" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0004980
4,980
melanocyte-stimulating hormone receptor activity
molecular_function
Combining with melanocyte-stimulating hormone to initiate a change in cell activity.
[ "GOC:jl", "PMID:7581459" ]
null
[ "melanocyte stimulating hormone receptor activity", "melanophore-stimulating hormone receptor activity", "MSH receptor activity", "MSHR activity" ]
[ "EXACT", "EXACT", "BROAD", "BROAD" ]
[]
[]
[]
[ "GO:0004977" ]
[ "has_part GO:0042562" ]
[ "has_part" ]
[ "GO:0042562" ]
[ "GO:0004977", "GO:0042562" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0004982
4,982
N-formyl peptide receptor activity
molecular_function
Combining with an N-formyl peptide to initiate a change in cell activity.
[ "GOC:ai" ]
null
[ "Fmet-leu-phe receptor" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0008528" ]
[]
[]
[]
[ "GO:0008528" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0004983
4,983
neuropeptide Y receptor activity
molecular_function
Combining with neuropeptide Y to initiate a change in cell activity.
[ "PMID:9315606" ]
null
[]
[]
[]
[]
[]
[ "GO:0008188" ]
[]
[]
[]
[ "GO:0008188" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0004984
4,984
olfactory receptor activity
molecular_function
Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.
[ "GOC:bf", "GOC:dph", "GOC:sart", "PMID:19135896", "PMID:21041441" ]
null
[ "odorant receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0004888" ]
[ "part_of GO:0050911" ]
[ "part_of" ]
[ "GO:0050911" ]
[ "GO:0004888", "GO:0050911" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0004985
4,985
G protein-coupled opioid receptor activity
molecular_function
Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein.
[ "GOC:ai", "GOC:bf", "PMID:20494127" ]
null
[ "opioid receptor activity" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0004930" ]
[ "part_of GO:0038003" ]
[ "part_of" ]
[ "GO:0038003" ]
[ "GO:0004930", "GO:0038003" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21110\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23197\" xsd:anyURI" ]
null
null
false
true
2
GO:0004986
4,986
obsolete delta-opioid receptor activity
molecular_function
OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of delta-opioid receptors, including the activity of enkephalins as ligands.
[ "IUPHAR_RECEPTOR:317", "PMID:10471416" ]
This term was made obsolete because the receptor is defined based on its pharmacological properties.
[ "delta-opioid receptor activity" ]
[ "EXACT" ]
[]
[]
[ "Wikipedia:Delta_Opioid_receptor" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0038046" ]
[]
null
null
true
true
5
GO:0004987
4,987
obsolete kappa-opioid receptor activity
molecular_function
OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of kappa-opioid receptors, including high affinity for dynorphins.
[ "IUPHAR_RECEPTOR:318" ]
This term was made obsolete because the receptor is defined based on its pharmacological properties.
[ "kappa-opioid receptor activity" ]
[ "EXACT" ]
[]
[]
[ "Wikipedia:Kappa_Opioid_receptor" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0038048" ]
[]
null
null
true
true
5
GO:0004989
4,989
octopamine receptor activity
molecular_function
Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist.
[ "GOC:ai" ]
null
[]
[]
[]
[]
[]
[ "GO:0008227" ]
[]
[]
[]
[ "GO:0008227" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0004991
4,991
parathyroid hormone receptor activity
molecular_function
Combining with parathyroid hormone to initiate a change in cell activity.
[ "GOC:mah" ]
null
[]
[]
[]
[]
[]
[ "GO:0004930" ]
[]
[]
[]
[ "GO:0004930" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0004992
4,992
platelet activating factor receptor activity
molecular_function
Combining with platelet activating factor to initiate a change in cell activity.
[ "GOC:mah" ]
null
[ "PAF receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0004930" ]
[]
[]
[]
[ "GO:0004930" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0004993
4,993
G protein-coupled serotonin receptor activity
molecular_function
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
[ "GOC:ai" ]
null
[ "5-HT receptor", "5-hydroxytryptamine receptor", "G protein coupled serotonin receptor activity", "G-protein coupled serotonin receptor activity" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[ "GO:0001585", "GO:0016609" ]
[]
[ "Wikipedia:5-HT_receptor" ]
[ "GO:0008227" ]
[ "has_part GO:0051378", "part_of GO:0098664" ]
[ "has_part", "part_of" ]
[ "GO:0051378", "GO:0098664" ]
[ "GO:0008227", "GO:0051378", "GO:0098664" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/12942\" xsd:anyURI" ]
null
null
false
true
7
GO:0004994
4,994
somatostatin receptor activity
molecular_function
Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid pep...
[ "GOC:ai", "GOC:bf", "Wikipedia:Somatostatin" ]
null
[ "GHIH receptor activity", "growth hormone-inhibiting hormone receptor activity", "somatotrophin release inhibiting factor receptor activity", "SRIF receptor activity", "SST receptor activity" ]
[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0008188" ]
[ "part_of GO:0038170" ]
[ "part_of" ]
[ "GO:0038170" ]
[ "GO:0008188", "GO:0038170" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0004995
4,995
tachykinin receptor activity
molecular_function
Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein.
[ "GOC:ai", "GOC:bf", "PMID:7639617", "Wikipedia:Tachykinin" ]
null
[]
[]
[]
[]
[]
[ "GO:0008188" ]
[ "part_of GO:0007217" ]
[ "part_of" ]
[ "GO:0007217" ]
[ "GO:0007217", "GO:0008188" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0004997
4,997
thyrotropin-releasing hormone receptor activity
molecular_function
Combining with thyrotropin-releasing hormone to initiate a change in cell activity.
[ "GOC:mah" ]
null
[]
[]
[]
[]
[]
[ "GO:0004930" ]
[]
[]
[]
[ "GO:0004930" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0004998
4,998
transferrin receptor activity
molecular_function
Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates.
[ "GOC:bf", "PMID:2678449", "PMID:3011819" ]
null
[]
[]
[]
[]
[]
[ "GO:0038024" ]
[]
[]
[]
[ "GO:0038024" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0004999
4,999
vasoactive intestinal polypeptide receptor activity
molecular_function
Combining with vasoactive intestinal polypeptide to initiate a change in cell activity.
[ "GOC:mah" ]
null
[]
[]
[]
[]
[]
[ "GO:0004930" ]
[]
[]
[]
[ "GO:0004930" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005000
5,000
vasopressin receptor activity
molecular_function
Combining with vasopressin to initiate a change in cell activity.
[ "GOC:ai" ]
null
[ "vasopressin activated calcium mobilizing receptor activity" ]
[ "NARROW" ]
[ "GO:0016931" ]
[]
[]
[ "GO:0008528" ]
[]
[]
[]
[ "GO:0008528" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0005001
5,001
transmembrane receptor protein tyrosine phosphatase activity
molecular_function
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[ "PMID:34353440" ]
null
[]
[]
[]
[]
[]
[ "GO:0004725", "GO:0019198" ]
[]
[]
[]
[ "GO:0004725", "GO:0019198" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28324\" xsd:anyURI" ]
null
null
false
true
5
GO:0005003
5,003
ephrin receptor activity
molecular_function
Combining with an ephrin receptor ligand to initiate a change in cell activity.
[ "GOC:mah", "PMID:9530499" ]
null
[ "Eph receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0004714" ]
[ "part_of GO:0048013" ]
[ "part_of" ]
[ "GO:0048013" ]
[ "GO:0004714", "GO:0048013" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0005004
5,004
GPI-linked ephrin receptor activity
molecular_function
Combining with a GPI-anchored ephrin to initiate a change in cell activity.
[ "GOC:mah", "PMID:9530499" ]
null
[ "GPI-linked Eph receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0005003" ]
[]
[]
[]
[ "GO:0005003" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.7.10.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]
null
null
false
true
2
GO:0005005
5,005
transmembrane-ephrin receptor activity
molecular_function
Combining with a transmembrane ephrin to initiate a change in cell activity.
[ "GOC:mah", "PMID:9530499" ]
null
[ "transmembrane-Eph receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0005003" ]
[]
[]
[]
[ "GO:0005003" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.7.10.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]
null
null
false
true
1
GO:0005006
5,006
epidermal growth factor receptor activity
molecular_function
Combining with an epidermal growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
[ "GOC:bf" ]
null
[ "EGF receptor activity", "EGFR", "epidermal growth factor-activated receptor activity", "TGF-alpha receptor activity", "transforming growth factor-alpha receptor activity" ]
[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]
[ "GO:0005023" ]
[]
[]
[ "GO:0004714" ]
[ "has_part GO:0048408", "part_of GO:0007173" ]
[ "has_part", "part_of" ]
[ "GO:0048408", "GO:0007173" ]
[ "GO:0004714", "GO:0007173", "GO:0048408" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.7.10.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23056\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30980\" xsd:anyURI" ]
null
null
false
true
1
GO:0005007
5,007
fibroblast growth factor receptor activity
molecular_function
Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
[ "GOC:mah" ]
Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand FGF. For receptors that bind other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888.
[ "FGF receptor activity", "FGF-activated receptor activity", "FGFR", "fibroblast growth factor-activated receptor activity" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004714" ]
[ "has_part GO:0017134", "part_of GO:0008543" ]
[ "has_part", "part_of" ]
[ "GO:0017134", "GO:0008543" ]
[ "GO:0004714", "GO:0008543", "GO:0017134" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.7.10.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23056\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]
null
null
false
true
2
GO:0005008
5,008
hepatocyte growth factor receptor activity
molecular_function
Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
[ "GOC:mah" ]
Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand HGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
[ "hepatocyte growth factor-activated receptor activity", "HGF receptor activity", "HGF-activated receptor activity" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004714" ]
[ "has_part GO:0036458", "part_of GO:0048012" ]
[ "has_part", "part_of" ]
[ "GO:0036458", "GO:0048012" ]
[ "GO:0004714", "GO:0036458", "GO:0048012" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.7.10.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23056\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30980\" xsd:anyURI" ]
null
null
false
true
9
GO:0005009
5,009
insulin receptor activity
molecular_function
Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
[ "ISBN:0198506732" ]
null
[ "insulin-activated receptor activity" ]
[ "EXACT" ]
[]
[]
[ "Reactome:R-HSA-74715 \"Autophosphorylation of insulin receptor\"" ]
[ "GO:0004714", "GO:0016500" ]
[ "has_part GO:0043559", "part_of GO:0008286" ]
[ "has_part", "part_of" ]
[ "GO:0043559", "GO:0008286" ]
[ "GO:0004714", "GO:0008286", "GO:0016500", "GO:0043559" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.7.10.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23056\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30980\" xsd:anyURI" ]
null
null
false
true
8
GO:0005010
5,010
insulin-like growth factor receptor activity
molecular_function
Combining with insulin-like growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
[ "GOC:mah" ]
Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand IGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
[ "IGF receptor activity", "IGF-activated receptor activity", "insulin-like growth factor-activated receptor activity" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004714" ]
[ "has_part GO:0005520", "part_of GO:0048009" ]
[ "has_part", "part_of" ]
[ "GO:0005520", "GO:0048009" ]
[ "GO:0004714", "GO:0005520", "GO:0048009" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.7.10.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23056\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]
null
null
false
true
9
GO:0005011
5,011
macrophage colony-stimulating factor receptor activity
molecular_function
Combining with macrophage colony-stimulating factor (M-CSF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
[ "GOC:mah", "GOC:signaling" ]
null
[ "CSF-1", "Fms", "M-CSF receptor activity", "macrophage colony stimulating factor receptor activity" ]
[ "NARROW", "NARROW", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004714" ]
[ "part_of GO:0038145" ]
[ "part_of" ]
[ "GO:0038145" ]
[ "GO:0004714", "GO:0038145" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.7.10.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]
null
null
false
true
3
GO:0005012
5,012
obsolete Neu/ErbB-2 receptor activity
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because it represents a class of receptor rather than an activity.
[ "Neu/ErbB-2 receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0043125" ]
[]
null
null
true
true
3
GO:0005013
5,013
obsolete neurotrophin TRK receptor activity
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:jid" ]
This term was made obsolete because it represents a gene product.
[ "neurotrophin TRK receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0004714", "GO:0007165", "GO:0019838", "GO:0043121" ]
[]
null
null
true
true
8
GO:0005014
5,014
obsolete neurotrophin TRKA receptor activity
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:jid" ]
This term was made obsolete because it represents a gene product.
[ "neurotrophin TRKA receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0004714", "GO:0007165", "GO:0043121", "GO:0048406" ]
[]
null
null
true
true
3
GO:0005015
5,015
obsolete neurotrophin TRKB receptor activity
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:jid" ]
This term was made obsolete because it represents a gene product.
[ "neurotrophin TRKB receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0004714", "GO:0007165", "GO:0043121", "GO:0048403" ]
[]
null
null
true
true
5
GO:0005016
5,016
obsolete neurotrophin TRKC receptor activity
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:jid" ]
This term was made obsolete because it represents a gene product.
[ "neurotrophin TRKC receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0004714", "GO:0007165", "GO:0043121" ]
[]
null
null
true
true
6
GO:0005017
5,017
platelet-derived growth factor receptor activity
molecular_function
Combining with platelet-derived growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
[ "GOC:mah" ]
Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand PDGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
[ "PDGF receptor activity", "PDGF-activated receptor activity", "PDGFR activity", "platelet-derived growth factor-activated receptor activity" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004714" ]
[ "has_part GO:0048407", "part_of GO:0036120", "part_of GO:0048008" ]
[ "has_part", "part_of", "part_of" ]
[ "GO:0048407", "GO:0036120", "GO:0048008" ]
[ "GO:0004714", "GO:0036120", "GO:0048008", "GO:0048407" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23056\" xsd:anyURI" ]
null
null
false
true
8
GO:0005019
5,019
platelet-derived growth factor beta-receptor activity
molecular_function
Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity.
[ "PMID:1657917" ]
null
[ "betaPDGF receptor activity", "PDGF beta-receptor activity" ]
[ "RELATED", "EXACT" ]
[]
[]
[]
[ "GO:0005017" ]
[ "part_of GO:0035791" ]
[ "part_of" ]
[ "GO:0035791" ]
[ "GO:0005017", "GO:0035791" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.7.10.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]
null
null
false
true
3
GO:0005020
5,020
stem cell factor receptor activity
molecular_function
Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell gro...
[ "GOC:jl", "GOC:signaling", "PMID:10698217" ]
null
[ "KIT", "KIT ligand receptor activity", "KL receptor activity", "SCF receptor activity" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004714" ]
[ "part_of GO:0038109" ]
[ "part_of" ]
[ "GO:0038109" ]
[ "GO:0004714", "GO:0038109" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.7.10.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30980\" xsd:anyURI" ]
null
null
false
true
3
GO:0005021
5,021
vascular endothelial growth factor receptor activity
molecular_function
Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
[ "GOC:mah", "GOC:signaling", "PMID:19909239" ]
Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand VEGF. For receptors that bind other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888.
[ "vascular endothelial growth factor E-activated receptor activity", "vascular endothelial growth factor-activated receptor activity", "VEGF receptor activity", "VEGF-A-activated receptor activity", "VEGF-activated receptor activity", "VEGF-B-activated receptor activity", "VEGF-C-activated receptor activ...
[ "EXACT", "EXACT", "EXACT", "NARROW", "EXACT", "NARROW", "NARROW", "NARROW", "NARROW", "EXACT" ]
[ "GO:0036326", "GO:0036327", "GO:0036328", "GO:0036329", "GO:0036330" ]
[]
[]
[ "GO:0004714" ]
[ "has_part GO:0038085", "part_of GO:0038084" ]
[ "has_part", "part_of" ]
[ "GO:0038085", "GO:0038084" ]
[ "GO:0004714", "GO:0038084", "GO:0038085" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.7.10.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23056\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]
null
null
false
true
6
GO:0005024
5,024
transforming growth factor beta receptor activity
molecular_function
Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
[ "GOC:mah", "GOC:signaling" ]
Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand TGFbeta. For binding to other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888.
[ "TGF-beta receptor activity", "TGFbeta receptor activity", "TGFbeta-activated receptor activity", "TGFbetaR", "transforming growth factor beta-activated receptor activity" ]
[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004675" ]
[]
[]
[]
[ "GO:0004675" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.7.11.30", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23056\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30980\" xsd:anyURI" ]
null
null
false
true
4
GO:0005025
5,025
transforming growth factor beta receptor activity, type I
molecular_function
Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals.
[ "GOC:mah" ]
null
[ "transforming growth factor beta ligand binding to type I receptor", "type I TGF-beta receptor activity", "type I TGFbeta receptor activity", "type I transforming growth factor beta receptor activity" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0005024" ]
[]
[]
[]
[ "GO:0005024" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.7.11.30", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]
null
null
false
true
6
GO:0005027
5,027
obsolete NGF/TNF (6 C-domain) receptor activity
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:jl" ]
This term was made obsolete because it represents a protein family rather than a molecular function.
[ "NGF/TNF (6 C-domain) receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0005031" ]
[]
null
null
true
true
5
GO:0005029
5,029
obsolete CD27 receptor activity
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:jl" ]
This term was made obsolete because it describes the receptor type, and not an activity.
[ "CD27 receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0042614" ]
[]
null
null
true
true
5
GO:0005030
5,030
neurotrophin receptor activity
molecular_function
Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity.
[ "GOC:jl", "GOC:signaling" ]
null
[]
[]
[]
[]
[]
[ "GO:0038023" ]
[ "has_part GO:0043121", "part_of GO:0038179" ]
[ "has_part", "part_of" ]
[ "GO:0043121", "GO:0038179" ]
[ "GO:0038023", "GO:0038179", "GO:0043121" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0005031
5,031
tumor necrosis factor receptor activity
molecular_function
Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
[ "GOC:jl", "http://lookwayup.com/" ]
null
[ "NGF/TNF (6 C-domain) receptor activity", "TNF receptor activity", "TNF receptor activity, type I", "TNF receptor activity, type II", "tumor necrosis factor receptor activity, type I", "tumor necrosis factor receptor activity, type II", "tumor necrosis factor-activated receptor activity" ]
[ "NARROW", "EXACT", "NARROW", "NARROW", "NARROW", "NARROW", "EXACT" ]
[ "GO:0005032", "GO:0005033" ]
[]
[]
[ "GO:0005035" ]
[ "has_part GO:0043120", "part_of GO:0033209" ]
[ "has_part", "part_of" ]
[ "GO:0043120", "GO:0033209" ]
[ "GO:0005035", "GO:0033209", "GO:0043120" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23056\" xsd:anyURI" ]
null
null
false
true
2
GO:0005034
5,034
osmosensor activity
molecular_function
Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell.
[ "GOC:dph", "GOC:tb" ]
null
[]
[]
[]
[]
[]
[ "GO:0004888", "GO:0140299" ]
[]
[]
[]
[ "GO:0004888", "GO:0140299" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0005035
5,035
death receptor activity
molecular_function
Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death.
[ "GOC:bf", "GOC:BHF", "GOC:ecd", "GOC:mtg_apoptosis", "GOC:rl", "PMID:10209153" ]
null
[ "apoptosis-activating receptor activity" ]
[ "RELATED" ]
[]
[]
[]
[ "GO:0004888" ]
[ "part_of GO:0012501" ]
[ "part_of" ]
[ "GO:0012501" ]
[ "GO:0004888", "GO:0012501" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0005037
5,037
obsolete death receptor adaptor protein activity
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:ai" ]
This term was made obsolete because it represents a gene product and not a molecular function.
[ "death receptor adaptor protein activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0005123", "GO:0005515" ]
[]
null
null
true
true
1
GO:0005038
5,038
obsolete death receptor interacting protein activity
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:ai" ]
This term was made obsolete because it represents a gene product and not a molecular function.
[ "death receptor interacting protein activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0005123", "GO:0005515" ]
[]
null
null
true
true
8
GO:0005041
5,041
low-density lipoprotein particle receptor activity
molecular_function
Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis.
[ "GOC:bf", "ISBN:0198506732" ]
null
[ "LDL receptor", "LDLR activity", "low-density lipoprotein receptor activity" ]
[ "EXACT", "EXACT", "RELATED" ]
[ "GO:0008032" ]
[]
[ "Reactome:R-HSA-2404131 \"LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol\"", "Reactome:R-HSA-2424254 \"LDLR transports extracellular CR:atREs to cytosol\"", "Wikipedia:LDL_receptor" ]
[ "GO:0030228" ]
[ "has_part GO:0030169" ]
[ "has_part" ]
[ "GO:0030169" ]
[ "GO:0030169", "GO:0030228" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0005042
5,042
netrin receptor activity
molecular_function
Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:dph", "GOC:signaling", "PMID:15960985" ]
null
[]
[]
[]
[]
[]
[ "GO:0004888" ]
[ "part_of GO:0038007" ]
[ "part_of" ]
[ "GO:0038007" ]
[ "GO:0004888", "GO:0038007" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0005043
5,043
netrin receptor activity involved in chemorepulsion
molecular_function
Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin.
[ "GOC:dph", "GOC:signaling" ]
null
[ "netrin receptor activity involved in negative chemotaxis", "repulsive netrin receptor activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0005042" ]
[ "part_of GO:0050919" ]
[ "part_of" ]
[ "GO:0050919" ]
[ "GO:0005042", "GO:0050919" ]
[ "GO:0005042", "part_of GO:0050919" ]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0005044
5,044
scavenger receptor activity
molecular_function
Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
[ "GOC:bf", "PMID:11790542", "PMID:12379907", "PMID:12621157", "PMID:20981357" ]
Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0038187' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. For receptors that transduce a signal rath...
[ "macrophage receptor activity" ]
[ "NARROW" ]
[]
[ "goslim_chembl" ]
[]
[ "GO:0038024" ]
[]
[]
[]
[ "GO:0038024" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0005045
5,045
obsolete endoplasmic reticulum receptor activity
molecular_function
OBSOLETE. A receptor in the endoplasmic reticulum.
[ "GOC:ai" ]
This term was made obsolete because it represents cellular component and molecular function information.
[ "endoplasmic reticulum receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0038024" ]
[]
null
null
true
true
6
GO:0005046
5,046
KDEL sequence binding
molecular_function
Binding to a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.
[ "GOC:ai" ]
null
[ "KDEL receptor activity" ]
[ "NARROW" ]
[]
[]
[]
[ "GO:0046923" ]
[]
[]
[]
[ "GO:0046923" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0005047
5,047
signal recognition particle binding
molecular_function
Binding to a signal recognition particle.
[ "ISBN:0198506732" ]
See also the cellular component term 'signal recognition particle, endoplasmic reticulum targeting ; GO:0005786'.
[ "docking protein", "signal recognition particle receptor" ]
[ "BROAD", "NARROW" ]
[]
[]
[]
[ "GO:0043021" ]
[]
[]
[]
[ "GO:0043021" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005049
5,049
nuclear export signal receptor activity
molecular_function
Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein.
[ "GOC:bf", "GOC:mah", "GOC:pg", "GOC:vw", "PMID:11743003", "PMID:25802992", "PMID:28713609", "Wikipedia:Nuclear_transport" ]
null
[ "exportin activity", "importin-alpha binding", "importin-alpha export receptor activity", "NES receptor" ]
[ "RELATED", "RELATED", "NARROW", "EXACT" ]
[ "GO:0008262" ]
[]
[ "Reactome:R-HSA-178215 \"SMAD7:SMURF1 complex is exported to the cytosol\"" ]
[ "GO:0140142" ]
[ "part_of GO:0051168" ]
[ "part_of" ]
[ "GO:0051168" ]
[ "GO:0051168", "GO:0140142" ]
[ "GO:0140142", "part_of GO:0051168" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14336\" xsd:anyURI" ]
null
null
false
true
7
GO:0005050
5,050
obsolete peroxisome receptor
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because it describes a cellular component.
[ "peroxisome receptor" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0005777", "GO:0038023" ]
[]
null
null
true
true
8
GO:0005052
5,052
peroxisome matrix targeting signal-1 binding
molecular_function
Binding to a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L.
[ "GOC:mah", "PMID:11687502" ]
null
[ "peroxisomal targeting signal 1 (PTS1) binding", "peroxisome targeting signal-1 binding", "peroxisome targeting signal-1 receptor", "PEX5", "PTS1 binding", "PTS1 receptor" ]
[ "EXACT", "EXACT", "NARROW", "NARROW", "EXACT", "NARROW" ]
[]
[]
[]
[ "GO:0000268" ]
[]
[]
[]
[ "GO:0000268" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005053
5,053
peroxisome matrix targeting signal-2 binding
molecular_function
Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F).
[ "GOC:mah", "PMID:11687502" ]
null
[ "peroxisomal targeting signal 2 (PTS2) binding", "peroxisome targeting signal-2 binding", "peroxisome targeting signal-2 receptor", "PEX7", "PTS2 binding", "PTS2 receptor" ]
[ "EXACT", "EXACT", "NARROW", "NARROW", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0000268" ]
[]
[]
[]
[ "GO:0000268" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005054
5,054
obsolete peroxisome integral membrane receptor
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because it describes a cellular component.
[ "Pas20p", "peroxisome integral membrane receptor" ]
[ "RELATED", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0038023" ]
[]
null
null
true
true
6
GO:0005055
5,055
laminin receptor activity
molecular_function
Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity.
[ "GOC:ai", "PMID:2970671" ]
Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'.
[]
[]
[]
[]
[]
[ "GO:0098631" ]
[ "has_part GO:0043236" ]
[ "has_part" ]
[ "GO:0043236" ]
[ "GO:0043236", "GO:0098631" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0005056
5,056
tiggrin receptor activity
molecular_function
Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
[ "GOC:mah", "GOC:signaling", "PMID:9521906" ]
null
[]
[]
[]
[]
[]
[ "GO:0004888" ]
[]
[]
[]
[ "GO:0004888" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0005057
5,057
obsolete signal transducer activity, downstream of receptor
molecular_function
OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell.
[ "GOC:bf" ]
This term was obsoleted because it was not clearly defined.
[ "intracellular signal transducer activity", "receptor signaling protein activity", "receptor signalling protein activity" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14232\" xsd:anyURI" ]
null
null
true
true
5
GO:0005061
5,061
obsolete aryl hydrocarbon receptor nuclear translocator activity
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:mah" ]
This term was made obsolete because it represents a gene product.
[ "aryl hydrocarbon receptor nuclear translocator activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
3
GO:0005065
5,065
obsolete heterotrimeric G-protein
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because it represents a cellular component and not a molecular function.
[ "heterotrimeric G-protein" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0005834" ]
[]
[]
null
null
true
true
8
GO:0005066
5,066
obsolete transmembrane receptor protein tyrosine kinase signaling protein activity
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
[ "transmembrane receptor protein tyrosine kinase signaling protein activity", "transmembrane receptor protein tyrosine kinase signalling protein activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0007169", "GO:0035556" ]
[]
null
null
true
true
8
GO:0005068
5,068
transmembrane receptor protein tyrosine kinase adaptor activity
molecular_function
The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way.
[ "GOC:mtg_MIT_16mar07", "PMID:10502414", "PMID:20565848" ]
null
[ "transmembrane receptor protein tyrosine kinase adaptor protein activity", "transmembrane receptor protein tyrosine kinase docking protein activity" ]
[ "EXACT", "RELATED" ]
[ "GO:0005069" ]
[]
[]
[ "GO:0030159", "GO:0030971" ]
[ "part_of GO:0007169" ]
[ "part_of" ]
[ "GO:0007169" ]
[ "GO:0007169", "GO:0030159", "GO:0030971" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0005070
5,070
obsolete SH3/SH2 adaptor activity
molecular_function
OBSOLETE. Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
[ "GOC:mah", "GOC:so" ]
This term was obsoleted because molecular adaptors should be represented by the type of molecules they serve to adapt, and not by their domains.
[ "SH3/SH2 adaptor protein activity" ]
[ "NARROW" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
8
GO:0005072
5,072
obsolete transforming growth factor beta receptor, cytoplasmic mediator activity
molecular_function
OBSOLETE. Activity of any of the molecules that transmit the signal from a TGF-beta receptor through the cytoplasm to the nucleus.
[ "GOC:hjd" ]
This term was obsoleted because it is redundant with other terms.
[ "TGF-beta receptor, cytoplasmic mediator activity", "TGFbeta receptor, cytoplasmic mediator activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0000981" ]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/16202\" xsd:anyURI" ]
null
null
true
true
7
GO:0005073
5,073
obsolete common-partner SMAD protein
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:mah" ]
This term was made obsolete because it names a family of gene products.
[ "common-partner SMAD protein" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
2
GO:0005074
5,074
obsolete inhibitory SMAD protein
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:mah" ]
This term was made obsolete because it names a family of gene products.
[ "inhibitory SMAD protein" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
9
GO:0005076
5,076
obsolete receptor signaling protein serine/threonine kinase signaling protein activity
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
[ "receptor signaling protein serine/threonine kinase signaling protein activity", "receptor signalling protein serine/threonine kinase signalling protein activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0035556" ]
[]
null
null
true
true
2
GO:0005079
5,079
obsolete protein kinase A anchoring activity
molecular_function
OBSOLETE. Binds to protein kinase A and anchors it to a particular subcellular location.
[ "PMID:10354567" ]
This term was made obsolete because it represents a combination of process and function information.
[ "A-kinase anchor protein activity", "AKAP activity", "protein kinase A anchoring activity" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0008104", "GO:0051018" ]
[]
null
null
true
true
9
GO:0005080
5,080
protein kinase C binding
molecular_function
Binding to protein kinase C.
[ "GOC:jl" ]
null
[ "PKC alpha binding", "PKC binding", "PKC delta binding", "PKC eta binding", "protein kinase C alpha binding", "protein kinase C delta binding", "protein kinase C eta binding" ]
[ "EXACT", "EXACT", "EXACT", "EXACT", "NARROW", "NARROW", "NARROW" ]
[ "GO:0072568", "GO:0072569", "GO:0097024" ]
[]
[]
[ "GO:0019901" ]
[]
[]
[]
[ "GO:0019901" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0005081
5,081
obsolete receptor signaling protein serine/threonine phosphatase signaling protein activity
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
[ "receptor signaling protein serine/threonine phosphatase signaling protein activity", "receptor signalling protein serine/threonine phosphatase signalling protein activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0035556" ]
[]
null
null
true
true
3
GO:0005082
5,082
obsolete receptor signaling protein tyrosine phosphatase signaling protein activity
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information.
[ "receptor signaling protein tyrosine phosphatase signaling protein activity", "receptor signalling protein tyrosine phosphatase signalling protein activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0035556" ]
[]
null
null
true
true
4
GO:0005085
5,085
guanyl-nucleotide exchange factor activity
molecular_function
Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular p...
[ "GOC:kd", "GOC:mah", "PMID:23303910", "PMID:27218782" ]
null
[ "ARF guanyl-nucleotide exchange factor activity", "cAMP-dependent guanyl-nucleotide exchange factor activity", "GDP-dissociation stimulator activity", "GDS", "GEF", "GNRP", "guanyl-nucleotide release factor activity", "guanyl-nucleotide releasing factor", "Rab guanyl-nucleotide exchange factor activ...
[ "NARROW", "NARROW", "EXACT", "EXACT", "EXACT", "NARROW", "EXACT", "EXACT", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "EXACT", "NARROW", "EXACT", "NARROW" ]
[ "GO:0005086", "GO:0005087", "GO:0005088", "GO:0005089", "GO:0005090", "GO:0008321", "GO:0008433", "GO:0016219", "GO:0016220", "GO:0017034", "GO:0017112", "GO:0017132", "GO:0019839", "GO:0030676" ]
[ "goslim_chembl", "goslim_drosophila", "goslim_yeast" ]
[ "Reactome:R-HSA-109807 \"GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS\"", "Reactome:R-HSA-109817 \"GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS\"", "Reactome:R-HSA-114544 \"p115-RhoGEF activation of RHOA\"", "Reactome:R-HSA-1168636 \"p-RasGRP1,3:DAG cause RAS to exchange GDP for...
[ "GO:0030695" ]
[ "negatively_regulates GO:0019003", "positively_regulates GO:0005525" ]
[ "negatively_regulates", "positively_regulates" ]
[ "GO:0019003", "GO:0005525" ]
[ "GO:0005525", "GO:0019003", "GO:0030695" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18749\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18750\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27684\" xsd:anyURI" ]
null
null
false
true
8
GO:0005091
5,091
guanyl-nucleotide exchange factor adaptor activity
molecular_function
The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.
[ "GOC:mtg_MIT_16mar07", "GOC:vw" ]
null
[]
[]
[]
[]
[]
[ "GO:0030674", "GO:0030695" ]
[]
[]
[]
[ "GO:0030674", "GO:0030695" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0005092
5,092
GDP-dissociation inhibitor activity
molecular_function
Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.
[ "GOC:mah" ]
null
[ "GDI" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0030695" ]
[ "positively_regulates GO:0019003" ]
[ "positively_regulates" ]
[ "GO:0019003" ]
[ "GO:0019003", "GO:0030695" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0005093
5,093
Rab GDP-dissociation inhibitor activity
molecular_function
Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding.
[ "GOC:mah" ]
null
[]
[]
[]
[]
[]
[ "GO:0005092" ]
[]
[]
[]
[ "GO:0005092" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0005094
5,094
Rho GDP-dissociation inhibitor activity
molecular_function
Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding.
[ "GOC:mah" ]
null
[]
[]
[]
[]
[]
[ "GO:0005092" ]
[]
[]
[]
[ "GO:0005092" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0005095
5,095
GTPase inhibitor activity
molecular_function
Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate.
[ "GOC:ai" ]
null
[ "GIP" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0004857", "GO:0030695" ]
[ "negatively_regulates GO:0003924" ]
[ "negatively_regulates" ]
[ "GO:0003924" ]
[ "GO:0003924", "GO:0004857", "GO:0030695" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0005096
5,096
GTPase activator activity
molecular_function
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
[ "GOC:mah" ]
Note that the name Sar derives from 'secretion-associated, Ras-related'.
[ "ARF GAP activity", "ARF GTPase activator activity", "GAP activity", "Rab GAP activity", "Rab GTPase activator activity", "Rac GAP activity", "Rac GTPase activator activity", "Ral GAP activity", "Ral GTPase activator activity", "Ran GAP activity", "Ran GTPase activator activity", "RanGAP", "...
[ "NARROW", "NARROW", "EXACT", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW" ]
[ "GO:0005097", "GO:0005098", "GO:0005099", "GO:0005100", "GO:0005101", "GO:0008060", "GO:0017123", "GO:0030675", "GO:0046582" ]
[]
[ "Reactome:R-HSA-392513 \"Rap1 signal termination by Rap1GAPs\"", "Reactome:R-HSA-399935 \"Inactivation of R-Ras by Sema3A-Plexin-A GAP activity\"", "Reactome:R-HSA-4093339 \"p120-RasGAP activates GTP hydrolysis on RAS, inactivating it\"", "Reactome:R-HSA-416546 \"Inactivation of R-Ras by Sema4D-Plexin-B1 GAP ...
[ "GO:0008047", "GO:0030695" ]
[ "positively_regulates GO:0003924" ]
[ "positively_regulates" ]
[ "GO:0003924" ]
[ "GO:0003924", "GO:0008047", "GO:0030695" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0005102
5,102
signaling receptor binding
molecular_function
Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
[ "GOC:bf", "GOC:ceb", "ISBN:0198506732" ]
Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'.
[ "receptor binding", "receptor ligand", "receptor-associated protein activity" ]
[ "BROAD", "NARROW", "RELATED" ]
[]
[ "goslim_agr", "goslim_chembl", "goslim_flybase_ribbon", "goslim_mouse", "goslim_plant" ]
[ "Wikipedia:Ligand_(biochemistry)" ]
[ "GO:0005515" ]
[]
[]
[]
[ "GO:0005515" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0005105
5,105
type 1 fibroblast growth factor receptor binding
molecular_function
Binding to a type 1 fibroblast growth factor receptor (FGFR1).
[ "GOC:ceb", "GOC:fb_curators" ]
Note that breathless is the Drosophila gene encoding the type 1 fibroblast growth factor receptor (FGFR1).
[ "breathless binding", "breathless ligand", "FGFR1 binding", "FGFR1 ligand", "type 1 fibroblast growth factor receptor ligand" ]
[ "NARROW", "NARROW", "BROAD", "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005104" ]
[]
[]
[]
[ "GO:0005104" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0005106
5,106
obsolete ephrin
molecular_function
OBSOLETE. A class of proteins that interact with the ephrin receptors.
[ "GOC:ai", "ISBN:0198506732" ]
This term was made obsolete because it refers to a class of gene products.
[ "ephrin" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0046875" ]
[]
null
null
true
true
4
GO:0005107
5,107
obsolete GPI-linked ephrin
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:ai" ]
This term was made obsolete because it refers to a class of gene products.
[ "GPI-linked ephrin" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0005886" ]
[]
null
null
true
true
4
GO:0005109
5,109
frizzled binding
molecular_function
Binding to a frizzled (fz) receptor.
[ "GOC:ceb" ]
null
[ "frizzled ligand", "frizzled-2 binding", "frizzled-2 ligand", "fz binding", "fz ligand", "fz2 binding", "fz2 ligand" ]
[ "NARROW", "NARROW", "NARROW", "EXACT", "NARROW", "NARROW", "NARROW" ]
[ "GO:0005110" ]
[ "goslim_chembl" ]
[]
[ "GO:0001664" ]
[]
[]
[]
[ "GO:0001664" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0005111
5,111
type 2 fibroblast growth factor receptor binding
molecular_function
Binding to a type 2 fibroblast growth factor receptor (FGFR2).
[ "GOC:fb_curators" ]
Note that heartless is the Drosophila gene encoding the type 2 fibroblast growth factor receptor (FGFR2).
[ "FGFR2 binding", "FGFR2 ligand", "heartless binding", "heartless ligand", "type 2 fibroblast growth factor receptor ligand" ]
[ "EXACT", "NARROW", "EXACT", "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005104" ]
[]
[]
[]
[ "GO:0005104" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005112
5,112
Notch binding
molecular_function
Binding to a Notch (N) protein, a surface receptor.
[ "GOC:ceb" ]
null
[ "N binding", "N ligand", "Notch ligand", "Notch receptor binding" ]
[ "EXACT", "NARROW", "NARROW", "EXACT" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0005113
5,113
patched binding
molecular_function
Binding to a patched (ptc) protein, a receptor for hedgehog proteins.
[ "GOC:ceb", "PMID:11731473" ]
null
[ "patched ligand", "ptc binding", "ptc ligand" ]
[ "NARROW", "EXACT", "NARROW" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005114
5,114
type II transforming growth factor beta receptor binding
molecular_function
Binding to a type II transforming growth factor beta receptor.
[ "GOC:ceb", "GOC:mah", "PMID:11252892" ]
null
[ "punt binding", "punt ligand", "TGF-beta type II binding", "transforming growth factor beta ligand binding to type II receptor", "transforming growth factor beta receptor type II binding", "type II TGF-beta binding" ]
[ "NARROW", "NARROW", "EXACT", "RELATED", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0005160" ]
[]
[]
[]
[ "GO:0005160" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0005115
5,115
receptor tyrosine kinase-like orphan receptor binding
molecular_function
Binding to a receptor tyrosine kinase-like orphan receptor (Ror).
[ "GOC:ceb", "GOC:vw" ]
null
[ "receptor tyrosine kinase-like orphan receptor ligand", "Ror binding", "Ror ligand" ]
[ "NARROW", "BROAD", "RELATED" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0005117
5,117
wishful thinking binding
molecular_function
Binding to wishful thinking (Wit), a type II bone morphogenic protein receptor.
[ "GOC:ceb", "PMID:11856529" ]
null
[ "SE20 receptor binding", "wishful thinking ligand", "Wit binding", "Wit ligand" ]
[ "NARROW", "NARROW", "EXACT", "NARROW" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005118
5,118
sevenless binding
molecular_function
Binding to a sevenless (sev) protein, a receptor tyrosine kinase.
[ "GOC:ceb", "PMID:3151175" ]
null
[ "sev binding", "sev ligand", "sevenless ligand" ]
[ "EXACT", "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005119
5,119
smoothened binding
molecular_function
Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals.
[ "GOC:ceb", "PMID:11731473" ]
null
[ "smo binding", "smo ligand", "smoothened ligand" ]
[ "EXACT", "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0001664" ]
[]
[]
[]
[ "GO:0001664" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0005121
5,121
Toll binding
molecular_function
Binding to a Toll protein, a transmembrane receptor.
[ "GOC:ceb" ]
null
[ "Tl binding", "Toll ligand", "Toll receptor binding" ]
[ "EXACT", "NARROW", "EXACT" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005122
5,122
torso binding
molecular_function
Binding to a torso (tor) protein, a receptor tyrosine kinase.
[ "GOC:ceb", "PMID:2927509" ]
null
[ "tor binding", "tor ligand", "torso ligand" ]
[ "EXACT", "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3