Datasets:
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GO

Dataset card Data Studio Files
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 Community
go_id
string
go_numeric_id
int64
name
string
namespace
string
definition
string
definition_xrefs
list
comment
string
synonyms
list
synonym_scopes
list
alt_ids
list
subsets
list
xrefs
list
is_a_ids
list
relationship_edges
list
relationship_types
list
relationship_target_ids
list
parent_ids
list
intersection_of
list
union_of
list
disjoint_from
list
replaced_by
list
consider
list
property_values
list
created_by
string
creation_date
string
is_obsolete
bool
in_go_basic
bool
split_bucket
int64
GO:0005123
5,123
death receptor binding
molecular_function
Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD).
[ "GOC:ceb", "GOC:rl", "PMID:15654015" ]
null
[ "APO binding", "death receptor adaptor protein activity", "death receptor interacting protein activity", "death receptor ligand", "death receptor-associated factor activity", "DR binding", "EDAR binding", "FAS binding", "KILLER binding", "NGFR binding", "TNFR1 binding", "TRAIL binding" ]
[ "NARROW", "RELATED", "RELATED", "NARROW", "RELATED", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW" ]
[]
[ "goslim_chembl" ]
[]
[ "GO:0032813" ]
[]
[]
[]
[ "GO:0032813" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005126
5,126
cytokine receptor binding
molecular_function
Binding to a cytokine receptor.
[ "GOC:mah", "GOC:vw" ]
null
[ "hematopoietin/interferon-class (D200-domain) cytokine receptor binding", "hematopoietin/interferon-class (D200-domain) cytokine receptor ligand" ]
[ "EXACT", "NARROW" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0005127
5,127
ciliary neurotrophic factor receptor binding
molecular_function
Binding to a ciliary neurotrophic factor receptor.
[ "GOC:ai" ]
null
[ "ciliary neurotrophic factor", "ciliary neurotrophic factor receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0005128
5,128
erythropoietin receptor binding
molecular_function
Binding to an erythropoietin receptor.
[ "GOC:ai" ]
null
[ "erythropoietin", "erythropoietin receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0005129
5,129
granulocyte macrophage colony-stimulating factor receptor binding
molecular_function
Binding to a granulocyte macrophage colony-stimulating factor receptor.
[ "GOC:ai" ]
null
[ "GM-CSF receptor binding", "GM-CSF receptor ligand", "GMC-SF receptor ligand", "granulocyte macrophage colony stimulating factor receptor binding", "granulocyte macrophage colony-stimulating factor", "granulocyte macrophage colony-stimulating factor receptor ligand" ]
[ "EXACT", "NARROW", "NARROW", "EXACT", "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005130
5,130
granulocyte colony-stimulating factor receptor binding
molecular_function
Binding to a granulocyte colony-stimulating factor receptor.
[ "GOC:ai" ]
null
[ "G-CSF receptor ligand", "GC-SF receptor ligand", "granulocyte colony stimulating factor receptor binding", "granulocyte colony-stimulating factor", "granulocyte colony-stimulating factor receptor ligand" ]
[ "EXACT", "EXACT", "EXACT", "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0005131
5,131
growth hormone receptor binding
molecular_function
Binding to a growth hormone receptor.
[ "GOC:ai" ]
null
[ "growth hormone", "growth hormone receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126", "GO:0051427" ]
[]
[]
[]
[ "GO:0005126", "GO:0051427" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005132
5,132
type I interferon receptor binding
molecular_function
Binding to an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2).
[ "GOC:ai", "GOC:signaling", "PMID:17502368" ]
null
[ "IFNAR binding", "IFNAR1 binding", "IFNAR2 binding", "interferon-alpha/beta", "interferon-alpha/beta receptor binding", "interferon-alpha/beta receptor ligand" ]
[ "RELATED", "NARROW", "NARROW", "NARROW", "EXACT", "NARROW" ]
[]
[]
[]
[ "GO:0005126", "GO:0044877" ]
[]
[]
[]
[ "GO:0005126", "GO:0044877" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0005133
5,133
type II interferon receptor binding
molecular_function
Binding to a type II interferon receptor. Type II interferon is also known as interferon-gamma.
[ "GOC:ai" ]
null
[ "interferon-gamma", "interferon-gamma receptor binding", "interferon-gamma receptor ligand" ]
[ "NARROW", "EXACT", "NARROW" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0005135
5,135
interleukin-3 receptor binding
molecular_function
Binding to an interleukin-3 receptor.
[ "GOC:ai" ]
null
[ "IL-3", "interleukin-3 receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0005136
5,136
interleukin-4 receptor binding
molecular_function
Binding to an interleukin-4 receptor.
[ "GOC:ai" ]
null
[ "IL-4", "interleukin-4 receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0005137
5,137
interleukin-5 receptor binding
molecular_function
Binding to an interleukin-5 receptor.
[ "GOC:ai" ]
null
[ "IL-5", "interleukin-5 receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[ "goslim_chembl" ]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0005139
5,139
interleukin-7 receptor binding
molecular_function
Binding to an interleukin-7 receptor.
[ "GOC:ai" ]
null
[ "IL-7", "interleukin-7 receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0005141
5,141
interleukin-10 receptor binding
molecular_function
Binding to an interleukin-10 receptor.
[ "GOC:ai" ]
null
[ "IL-10", "interleukin-10 receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005142
5,142
interleukin-11 receptor binding
molecular_function
Binding to an interleukin-11 receptor.
[ "GOC:ai" ]
null
[ "IL-11", "interleukin-11 receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0005144
5,144
interleukin-13 receptor binding
molecular_function
Binding to an interleukin-13 receptor.
[ "GOC:ai" ]
null
[ "IL-13", "interleukin-13 receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0005145
5,145
obsolete interleukin-14 receptor binding
molecular_function
OBSOLETE. Binding to an interleukin-14 receptor.
[ "GOC:ai" ]
This term was obsoleted because the gene was shown not to exist, see PMID:8755619.
[ "IL-14", "interleukin-14 receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22446\" xsd:anyURI" ]
null
null
true
true
2
GO:0005146
5,146
leukemia inhibitory factor receptor binding
molecular_function
Binding to an leukemia inhibitory factor receptor.
[ "GOC:ai" ]
null
[ "leukemia inhibitory factor", "leukemia inhibitory factor receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005147
5,147
oncostatin-M receptor binding
molecular_function
Binding to an oncostatin-M receptor.
[ "GOC:ai" ]
null
[ "oncostatin-M", "oncostatin-M receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0005148
5,148
prolactin receptor binding
molecular_function
Binding to a prolactin receptor.
[ "GOC:ai" ]
null
[ "prolactin", "prolactin receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0005149
5,149
interleukin-1 receptor binding
molecular_function
Binding to an interleukin-1 receptor.
[ "GOC:curators" ]
null
[ "IL-1", "interleukin-1 receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0005150
5,150
interleukin-1, type I receptor binding
molecular_function
Binding to a Type I interleukin-1 receptor.
[ "GOC:ai" ]
null
[ "IL-1 type I", "interleukin-1, type I receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005149" ]
[]
[]
[]
[ "GO:0005149" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0005151
5,151
interleukin-1, type II receptor binding
molecular_function
Binding to a Type II interleukin-1 receptor.
[ "GOC:ai" ]
null
[ "IL-1 type II", "interleukin-1, type II receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005149" ]
[]
[]
[]
[ "GO:0005149" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0005152
5,152
interleukin-1 receptor antagonist activity
molecular_function
Blocks the binding of interleukin-1 to the interleukin-1 receptor complex.
[ "GOC:ebc" ]
null
[ "IL-1ra" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0005126", "GO:0019966", "GO:0048019" ]
[ "part_of GO:0001960" ]
[ "part_of" ]
[ "GO:0001960" ]
[ "GO:0001960", "GO:0005126", "GO:0019966", "GO:0048019" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0005153
5,153
interleukin-8 receptor binding
molecular_function
Binding to an interleukin-8 receptor.
[ "GOC:curators" ]
null
[ "IL-8", "interleukin-8 receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[ "goslim_chembl" ]
[]
[ "GO:0045236" ]
[]
[]
[]
[ "GO:0045236" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0005154
5,154
epidermal growth factor receptor binding
molecular_function
Binding to an epidermal growth factor receptor.
[ "GOC:ai" ]
null
[ "EGF", "EGF receptor binding", "EGF receptor ligand", "EGFR binding", "epidermal growth factor", "epidermal growth factor receptor ligand", "TGF-alpha receptor binding", "TGFalpha receptor binding", "transforming growth factor alpha", "transforming growth factor alpha receptor binding", "transfo...
[ "NARROW", "EXACT", "NARROW", "EXACT", "NARROW", "NARROW", "EXACT", "EXACT", "NARROW", "EXACT", "NARROW" ]
[ "GO:0008185" ]
[ "goslim_chembl" ]
[]
[ "GO:0070851" ]
[]
[]
[]
[ "GO:0070851" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0005155
5,155
obsolete epidermal growth factor receptor activating ligand activity
molecular_function
OBSOLETE. This term was not defined before being made obsolete.
[ "GOC:dph", "GOC:mah", "GOC:tb" ]
This term was made obsolete because it represents both a biological process and a molecular function.
[ "EGF receptor activating ligand activity", "EGFR activating ligand activity", "epidermal growth factor receptor activating ligand activity" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0048018" ]
[]
[]
null
null
true
true
9
GO:0005156
5,156
obsolete epidermal growth factor receptor inhibiting ligand activity
molecular_function
OBSOLETE. This term was not defined before being made obsolete.
[ "GOC:dph", "GOC:mah", "GOC:tb" ]
This term was made obsolete because it represents both a biological process and a molecular function.
[ "EGF receptor inhibiting ligand activity", "EGFR inhibiting ligand activity", "epidermal growth factor receptor inhibiting ligand activity" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0141069" ]
[]
[]
null
null
true
true
8
GO:0005157
5,157
macrophage colony-stimulating factor receptor binding
molecular_function
Binding to a macrophage colony-stimulating factor receptor.
[ "GOC:ai" ]
null
[ "M-CSF receptor binding", "macrophage colony stimulating factor receptor binding", "macrophage colony-stimulating factor receptor ligand" ]
[ "EXACT", "EXACT", "NARROW" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0005158
5,158
insulin receptor binding
molecular_function
Binding to an insulin receptor.
[ "GOC:ai" ]
null
[ "insulin receptor ligand" ]
[ "NARROW" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0005159
5,159
insulin-like growth factor receptor binding
molecular_function
Binding to an insulin-like growth factor receptor.
[ "GOC:jl" ]
null
[ "IGF receptor binding", "insulin-like growth factor", "insulin-like growth factor receptor ligand" ]
[ "EXACT", "NARROW", "NARROW" ]
[ "GO:0005067" ]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0005160
5,160
transforming growth factor beta receptor binding
molecular_function
Binding to a transforming growth factor beta receptor.
[ "GOC:ai" ]
null
[ "activin", "inhibin", "TGF-beta receptor binding", "TGFbeta receptor binding", "transforming growth factor beta", "transforming growth factor beta ligand binding to type I receptor", "transforming growth factor beta ligand binding to type II receptor", "transforming growth factor beta receptor anchori...
[ "RELATED", "RELATED", "EXACT", "EXACT", "NARROW", "RELATED", "RELATED", "RELATED", "NARROW" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0005161
5,161
platelet-derived growth factor receptor binding
molecular_function
Binding to a platelet-derived growth factor receptor.
[ "GOC:ai" ]
null
[ "PDGF", "PDGF receptor binding", "PDGFR binding", "platelet-derived growth factor", "platelet-derived growth factor receptor ligand" ]
[ "NARROW", "EXACT", "EXACT", "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0070851" ]
[]
[]
[]
[ "GO:0070851" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0005163
5,163
nerve growth factor receptor binding
molecular_function
Binding to a nerve growth factor receptor.
[ "GOC:ai", "PMID:15654015" ]
null
[ "nerve growth factor receptor ligand", "neurotrophin", "NGF receptor binding" ]
[ "NARROW", "NARROW", "EXACT" ]
[]
[]
[]
[ "GO:0005123", "GO:0005165" ]
[]
[]
[]
[ "GO:0005123", "GO:0005165" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0005164
5,164
tumor necrosis factor receptor binding
molecular_function
Binding to a tumor necrosis factor receptor.
[ "GOC:ai" ]
null
[ "TNF receptor binding", "tumor necrosis factor", "tumor necrosis factor receptor ligand" ]
[ "EXACT", "NARROW", "NARROW" ]
[]
[ "goslim_chembl" ]
[]
[ "GO:0032813" ]
[]
[]
[]
[ "GO:0032813" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0005165
5,165
neurotrophin receptor binding
molecular_function
Binding to a neurotrophin receptor.
[ "GOC:ai" ]
null
[ "neurotrophin", "neurotrophin receptor ligand" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0005166
5,166
neurotrophin p75 receptor binding
molecular_function
Binding to a neurotrophin p75 receptor.
[ "GOC:ai" ]
null
[ "neurotrophin p75 receptor ligand" ]
[ "NARROW" ]
[]
[]
[]
[ "GO:0005165" ]
[]
[]
[]
[ "GO:0005165" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0005167
5,167
neurotrophin TRK receptor binding
molecular_function
Binding to a neurotrophin TRK receptor.
[ "GOC:ai" ]
null
[ "neurotrophin TRK receptor ligand" ]
[ "NARROW" ]
[]
[]
[]
[ "GO:0005165" ]
[]
[]
[]
[ "GO:0005165" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0005168
5,168
neurotrophin TRKA receptor binding
molecular_function
Binding to a neurotrophin TRKA receptor.
[ "GOC:ai" ]
null
[ "neurotrophin TRKA receptor ligand" ]
[ "NARROW" ]
[]
[]
[]
[ "GO:0005167" ]
[]
[]
[]
[ "GO:0005167" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0005169
5,169
neurotrophin TRKB receptor binding
molecular_function
Binding to a neurotrophin TRKB receptor.
[ "GOC:ai" ]
null
[ "neurotrophin TRKB receptor ligand" ]
[ "NARROW" ]
[]
[]
[]
[ "GO:0005167" ]
[]
[]
[]
[ "GO:0005167" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005170
5,170
neurotrophin TRKC receptor binding
molecular_function
Binding to a neurotrophin TRKC receptor.
[ "GOC:ai" ]
null
[ "neurotrophin TRKC receptor ligand" ]
[ "NARROW" ]
[]
[]
[]
[ "GO:0005167" ]
[]
[]
[]
[ "GO:0005167" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0005171
5,171
hepatocyte growth factor receptor binding
molecular_function
Binding to an hepatocyte growth factor receptor.
[ "GOC:ai" ]
null
[ "hepatocyte growth factor", "hepatocyte growth factor receptor ligand", "HGF receptor binding" ]
[ "NARROW", "NARROW", "EXACT" ]
[]
[]
[]
[ "GO:0070851" ]
[]
[]
[]
[ "GO:0070851" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0005172
5,172
vascular endothelial growth factor receptor binding
molecular_function
Binding to a vascular endothelial growth factor receptor.
[ "GOC:ai" ]
null
[ "vascular endothelial growth factor", "vascular endothelial growth factor receptor ligand", "VEGF receptor binding", "VEGFR binding" ]
[ "NARROW", "NARROW", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[ "GO:0005126", "GO:0070851" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0005173
5,173
stem cell factor receptor binding
molecular_function
Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor.
[ "GOC:jl", "PMID:10698217" ]
null
[ "KIT binding", "SCF", "SCFR binding", "stem cell factor", "stem cell factor receptor ligand" ]
[ "NARROW", "NARROW", "EXACT", "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[ "GO:0005126" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0005174
5,174
CD40 receptor binding
molecular_function
Binding to CD40, a receptor found on the surface of all B-lymphocytes.
[ "GOC:jl", "ISBN:0120781859" ]
null
[]
[]
[]
[]
[]
[ "GO:0032813" ]
[]
[]
[]
[ "GO:0032813" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0005175
5,175
CD27 receptor binding
molecular_function
Binding to a CD27, a receptor found on the surface of T cells and some B cells and NK cells.
[ "GOC:jl", "ISBN:0120781859" ]
null
[]
[]
[]
[]
[]
[ "GO:0032813" ]
[]
[]
[]
[ "GO:0032813" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0005176
5,176
ErbB-2 class receptor binding
molecular_function
Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2.
[ "GOC:jl" ]
null
[ "ErbB-2 class receptor ligand", "HER2 receptor binding", "HER2 receptor ligand", "Neu receptor binding", "Neu receptor ligand" ]
[ "NARROW", "EXACT", "NARROW", "EXACT", "NARROW" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[ "GO:0005102" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0005177
5,177
obsolete neuroligin
molecular_function
OBSOLETE. A class of ligands for neurexins.
[ "GOC:ai" ]
null
[ "neuroligin" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0042043" ]
[]
null
null
true
true
1
GO:0005179
5,179
hormone activity
molecular_function
The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with...
[ "GOC:dph", "GOC:mah", "ISBN:0198506732" ]
Also consider annotating to 'receptor agonist activity ; GO:0048018'.
[ "cAMP generating peptide activity", "glycopeptide hormone", "lipopeptide hormone", "peptide hormone" ]
[ "NARROW", "NARROW", "NARROW", "NARROW" ]
[]
[ "goslim_chembl" ]
[]
[ "GO:0048018" ]
[]
[]
[]
[ "GO:0048018" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0005180
5,180
obsolete peptide hormone
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:ai" ]
This term was made obsolete because it describes a type of hormone rather than a molecular function.
[ "peptide hormone" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0005179" ]
[]
null
null
true
true
2
GO:0005182
5,182
obsolete lipopeptide hormone
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:ai" ]
This term was made obsolete because it describes a type of hormone rather than a molecular function.
[ "lipopeptide hormone" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0005179" ]
[]
null
null
true
true
9
GO:0005183
5,183
gonadotropin hormone-releasing hormone activity
molecular_function
The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and lut...
[ "ISBN:0198506732", "PMID:11026571", "Wikipedia:Gonadotropin-releasing_hormone" ]
null
[ "GnRH activity", "gonadotrophin hormone-releasing hormone activity", "LH/FSH-RF", "LHRH activity", "luteinizing hormone-releasing factor activity", "luteinizing hormone-releasing hormone activity", "luteinizing hormone/follicle-stimulating hormone releasing factor activity" ]
[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0005179" ]
[]
[]
[]
[ "GO:0005179" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0005184
5,184
neuropeptide hormone activity
molecular_function
The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in...
[ "GOC:mah" ]
null
[ "neurohormone" ]
[ "EXACT" ]
[]
[ "goslim_chembl" ]
[ "Wikipedia:Neurohormone" ]
[ "GO:0005179", "GO:0160041" ]
[]
[]
[]
[ "GO:0005179", "GO:0160041" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005187
5,187
obsolete storage protein
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because it describes a cellular location rather than a function.
[ "storage protein" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0045735" ]
[]
[]
null
null
true
true
8
GO:0005188
5,188
obsolete larval serum protein (sensu Insecta)
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:mah" ]
This term was made obsolete because it describes presence in body fluids rather than an activity.
[ "arylphorin", "larval serum protein (sensu Insecta)" ]
[ "NARROW", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
8
GO:0005189
5,189
obsolete milk protein
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:mah" ]
This term was made obsolete because it describes presence in body fluids rather than an activity.
[ "milk protein" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
6
GO:0005190
5,190
obsolete seminal fluid protein
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:mah" ]
This term was made obsolete because it describes presence in body fluids rather than an activity.
[ "seminal fluid protein" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
5
GO:0005192
5,192
obsolete urinary protein
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:mah" ]
This term was made obsolete because it describes presence in body fluids rather than an activity.
[ "urinary protein" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
9
GO:0005193
5,193
obsolete major urinary protein
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:mah" ]
This term was made obsolete because it describes presence in body fluids rather than an activity.
[ "major urinary protein" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
5
GO:0005194
5,194
obsolete cell adhesion molecule activity
molecular_function
OBSOLETE. Mediates the adhesion of the cell to other cells or to the extracellular matrix.
[ "ISBN:0198506732" ]
This term was made obsolete because it represents gene products involved in the biological process of cell adhesion.
[ "cell adhesion molecule activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0005102", "GO:0005515", "GO:0007155", "GO:0030246", "GO:0050839", "GO:0098631" ]
[]
null
null
true
true
9
GO:0005199
5,199
structural constituent of cell wall
molecular_function
The action of a molecule that contributes to the structural integrity of a cell wall.
[ "GOC:mah" ]
null
[]
[]
[]
[]
[]
[ "GO:0005198" ]
[ "occurs_in GO:0005618" ]
[ "occurs_in" ]
[ "GO:0005618" ]
[ "GO:0005198", "GO:0005618" ]
[ "GO:0005198", "occurs_in GO:0005618" ]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005200
5,200
structural constituent of cytoskeleton
molecular_function
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
[ "GOC:mah" ]
null
[]
[]
[]
[ "goslim_drosophila" ]
[]
[ "GO:0005198" ]
[ "occurs_in GO:0005856", "part_of GO:0007010" ]
[ "occurs_in", "part_of" ]
[ "GO:0005856", "GO:0007010" ]
[ "GO:0005198", "GO:0005856", "GO:0007010" ]
[ "GO:0005198", "occurs_in GO:0005856", "part_of GO:0007010" ]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005201
5,201
extracellular matrix structural constituent
molecular_function
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
[ "GOC:mah" ]
Extracellular matrix glycoproteins may be annotated to this term. PMID:24443019
[ "core extracellular matrix", "core matrisome", "extracellular matrix glycoprotein" ]
[ "BROAD", "BROAD", "NARROW" ]
[]
[ "goslim_drosophila" ]
[]
[ "GO:0005198" ]
[ "occurs_in GO:0031012" ]
[ "occurs_in" ]
[ "GO:0031012" ]
[ "GO:0005198", "GO:0031012" ]
[ "GO:0005198", "occurs_in GO:0031012" ]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0005202
5,202
obsolete collagen
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because it does not represent a molecular function.
[ "collagen" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0005581" ]
[]
null
null
true
true
7
GO:0005203
5,203
obsolete proteoglycan
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function.
[ "proteoglycan" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
2
GO:0005204
5,204
obsolete chondroitin sulfate proteoglycan
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function.
[ "chondroitin sulfate proteoglycan", "chondroitin sulphate proteoglycan" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
2
GO:0005205
5,205
obsolete chondroitin sulfate/dermatan sulfate proteoglycan
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function.
[ "chondroitin sulfate/dermatan sulfate proteoglycan", "chondroitin sulphate/dermatan sulphate proteoglycan" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
3
GO:0005206
5,206
obsolete heparin sulfate proteoglycan
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:mah" ]
This term was made obsolete because it represents a gene product.
[ "heparin sulfate proteoglycan", "heparin sulphate proteoglycan" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
2
GO:0005207
5,207
obsolete extracellular matrix glycoprotein
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:mah" ]
This term was made obsolete because it describes localization and modification rather than activity.
[ "extracellular matrix glycoprotein" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0005201" ]
[]
null
null
true
true
8
GO:0005208
5,208
obsolete amyloid protein
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:mah" ]
This term was made obsolete because it represents a gene product.
[ "amyloid protein" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
9
GO:0005209
5,209
obsolete plasma protein
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:mah" ]
This term was made obsolete because it describes presence in body fluids rather than an activity.
[ "plasma protein" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
1
GO:0005211
5,211
obsolete plasma glycoprotein
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:mah" ]
This term was made obsolete because it describes modification and presence in body fluids rather than an activity.
[ "plasma glycoprotein" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
9
GO:0005212
5,212
structural constituent of eye lens
molecular_function
The action of a molecule that contributes to the structural integrity of the lens of an eye.
[ "GOC:mah" ]
null
[]
[]
[]
[]
[]
[ "GO:0005198" ]
[]
[]
[]
[ "GO:0005198" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005213
5,213
structural constituent of egg chorion
molecular_function
The action of a molecule that contributes to the structural integrity of an egg chorion. An example of this is found in Drosophila melanogaster.
[ "GOC:mah", "GOC:sensu" ]
null
[ "structural constituent of chorion", "structural protein of chorion" ]
[ "BROAD", "NARROW" ]
[]
[]
[]
[ "GO:0005198" ]
[ "occurs_in GO:0042600" ]
[ "occurs_in" ]
[ "GO:0042600" ]
[ "GO:0005198", "GO:0042600" ]
[ "GO:0005198", "occurs_in GO:0042600" ]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0005214
5,214
structural constituent of chitin-based cuticle
molecular_function
The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster.
[ "GOC:mah", "GOC:mtg_sensu" ]
null
[]
[]
[]
[]
[]
[ "GO:0042302" ]
[]
[]
[]
[ "GO:0042302" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0005215
5,215
transporter activity
molecular_function
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.
[ "GOC:ai", "GOC:dgf" ]
Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules.
[ "carrier" ]
[ "RELATED" ]
[ "GO:0005478" ]
[ "gocheck_do_not_annotate", "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_euk_cellular_processes_ribbon", "goslim_flybase_ribbon", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_plant", "goslim_plant_ribbon", "goslim_prokaryote", "goslim_prokaryote...
[]
[ "GO:0003674" ]
[]
[]
[]
[ "GO:0003674" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27621\" xsd:anyURI" ]
null
null
false
true
7
GO:0005216
5,216
monoatomic ion channel activity
molecular_function
Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more i...
[ "GOC:cy", "GOC:mtg_transport", "GOC:pr", "ISBN:0815340729" ]
null
[ "ion channel activity" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0015075", "GO:0015267" ]
[]
[]
[]
[ "GO:0015075", "GO:0015267" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24479\" xsd:anyURI" ]
null
null
false
true
7
GO:0005217
5,217
intracellularly ligand-gated monoatomic ion channel activity
molecular_function
Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.
[ "GOC:mtg_transport", "ISBN:0815340729" ]
null
[ "intracellular ligand-gated ion channel activity", "intracellular ligand-gated monoatomic ion channel activity" ]
[ "BROAD", "EXACT" ]
[]
[]
[]
[ "GO:0015276" ]
[]
[]
[]
[ "GO:0015276" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0005219
5,219
ryanodine-sensitive calcium-release channel activity
molecular_function
Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration and is sensitive to the plant alkaloid ryanodine.
[ "GOC:dph", "GOC:tb", "PMID:22822064" ]
null
[ "caffeine-sensitive calcium-release channel", "ryanodine receptor" ]
[ "RELATED", "NARROW" ]
[]
[]
[]
[ "GO:0048763" ]
[]
[]
[]
[ "GO:0048763" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0005220
5,220
inositol 1,4,5-trisphosphate-gated calcium channel activity
molecular_function
Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts.
[ "GOC:mah", "GOC:signaling", "PMID:28416699", "PMID:8660280", "Wikipedia:Inositol_trisphosphate_receptor" ]
null
[ "inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity", "inositol-1,4,5-trisphosphate receptor activity", "InsP3 receptor", "IP3 receptor activity" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[ "GO:0008095" ]
[]
[]
[ "GO:0015278" ]
[ "has_part GO:0070679" ]
[ "has_part" ]
[ "GO:0070679" ]
[ "GO:0015278", "GO:0070679" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27339\" xsd:anyURI" ]
null
null
false
true
8
GO:0005221
5,221
intracellularly cyclic nucleotide-activated monoatomic cation channel activity
molecular_function
Enables the transmembrane transfer of a monoatomic cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts.
[ "GOC:mtg_transport" ]
null
[ "intracellular cyclic nucleotide activated cation channel activity", "intracellular cyclic nucleotide activated monoatomic cation channel activity", "intracellular cyclic nucleotide-activated monoatomic cation channel activity" ]
[ "BROAD", "EXACT", "EXACT" ]
[]
[]
[ "Reactome:R-HSA-2514867 \"cGMP:CNG transports Na+ and Ca2+ into the rod outer segment\"" ]
[ "GO:0005217", "GO:0043855", "GO:0099094" ]
[]
[]
[]
[ "GO:0005217", "GO:0043855", "GO:0099094" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24479\" xsd:anyURI" ]
null
null
false
true
8
GO:0005222
5,222
intracellularly cAMP-activated cation channel activity
molecular_function
Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts.
[ "GOC:mtg_transport" ]
null
[ "HCN channel activity", "hyperpolarization-activated cyclic nucleotide-gated channel activity", "intracellular 3',5' cAMP activated cation channel activity", "intracellular 3',5'-cAMP activated cation channel activity", "intracellular adenosine 3',5'-cyclophosphate activated cation channel activity", "int...
[ "BROAD", "BROAD", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0005221" ]
[]
[]
[]
[ "GO:0005221" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0005223
5,223
intracellularly cGMP-activated cation channel activity
molecular_function
Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts.
[ "GOC:mtg_transport" ]
null
[ "intracellular cGMP activated cation channel activity", "intracellular cGMP-activated cation channel activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0005221" ]
[]
[]
[]
[ "GO:0005221" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0005225
5,225
volume-sensitive anion channel activity
molecular_function
Enables the transmembrane transfer of a monoatomic anion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell.
[ "GOC:dph", "GOC:tb" ]
null
[ "volume-regulated channel" ]
[ "BROAD" ]
[]
[]
[ "Reactome:R-HSA-8941543 \"VRAC heteromer transports I-, Cl- from cytosol to extracellular region\"" ]
[ "GO:0005253" ]
[]
[]
[]
[ "GO:0005253" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0005227
5,227
calcium-activated cation channel activity
molecular_function
Enables the transmembrane transfer of an inorganic cation by a channel that opens when a calcium cation has been bound by the channel complex or one of its constituent parts.
[ "GOC:dph", "GOC:mtg_transport" ]
null
[ "calcium activated cation channel activity", "intracellular calcium-activated potassium channel", "polycystin" ]
[ "EXACT", "NARROW", "NARROW" ]
[]
[]
[ "Reactome:R-HSA-9717383 \"TRPM4 transports Na+ from the extracellular region to the cytosol\"" ]
[ "GO:0022839", "GO:0099094" ]
[]
[]
[]
[ "GO:0022839", "GO:0099094" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24605\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28979\" xsd:anyURI" ]
null
null
false
true
9
GO:0005228
5,228
intracellular sodium-activated potassium channel activity
molecular_function
Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-...
[ "GOC:mtg_transport", "PMID:12628167" ]
null
[ "intracellular sodium activated potassium channel activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0005267", "GO:0022839", "GO:0099094" ]
[]
[]
[]
[ "GO:0005267", "GO:0022839", "GO:0099094" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0005229
5,229
intracellularly calcium-gated chloride channel activity
molecular_function
Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence f...
[ "GOC:mtg_transport", "PMID:29236691" ]
null
[ "intracellular calcium activated chloride channel activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0005254", "GO:0099095", "GO:0141147" ]
[]
[]
[]
[ "GO:0005254", "GO:0099095", "GO:0141147" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26874\" xsd:anyURI" ]
null
null
false
true
6
GO:0005230
5,230
extracellular ligand-gated monoatomic ion channel activity
molecular_function
Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts.
[ "GOC:mtg_transport", "ISBN:0815340729" ]
null
[ "extracellular ligand-gated ion channel activity" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0015276" ]
[]
[]
[]
[ "GO:0015276" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0005231
5,231
excitatory extracellular ligand-gated monoatomic ion channel activity
molecular_function
Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential.
[ "GOC:mah", "ISBN:0323037070" ]
null
[]
[]
[]
[]
[ "Reactome:R-HSA-399711 \"Activation of Ca impermeable AMPA receptors\"", "Reactome:R-HSA-399712 \"Activation of Ca permeable AMPA receptors\"", "Reactome:R-HSA-420980 \"Activation of Ca permeable AMPA receptors\"", "Reactome:R-HSA-432164 \"Ca2+ influx into the post-synaptic cell\"", "Reactome:R-HSA-438037 \...
[ "GO:0005230" ]
[ "part_of GO:0060079" ]
[ "part_of" ]
[ "GO:0060079" ]
[ "GO:0005230", "GO:0060079" ]
[ "GO:0005230", "part_of GO:0060079" ]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0005234
5,234
extracellularly glutamate-gated ion channel activity
molecular_function
Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
[ "GOC:mtg_transport", "ISBN:0815340729" ]
Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'.
[ "extracellular-glutamate-gated ion channel activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0005231" ]
[]
[]
[]
[ "GO:0005231" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0005237
5,237
inhibitory extracellular ligand-gated monoatomic ion channel activity
molecular_function
Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels.
[ "GOC:mah", "ISBN:0323037070" ]
null
[ "inhibitory extracellular ligand-gated ion channel activity" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0005230" ]
[]
[]
[]
[ "GO:0005230" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0005240
5,240
obsolete glycine receptor-associated protein
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:ai" ]
This term was made obsolete because it does not describe a molecular function.
[ "glycine receptor-associated protein" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0005515" ]
[]
null
null
true
true
7
GO:0005241
5,241
obsolete inward rectifier channel
molecular_function
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because more specific terms were created.
[ "inward rectifier channel" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0005242" ]
[]
null
null
true
true
2
GO:0005242
5,242
inward rectifier potassium channel activity
molecular_function
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-...
[ "GOC:cb", "GOC:mah", "PMID:14977398" ]
null
[ "Kir channel activity" ]
[ "EXACT" ]
[]
[]
[ "Reactome:R-HSA-1296045 \"Activation of Potassium transport channels\"", "Reactome:R-HSA-1296046 \"KCNJs transport K+ from the extracellular region to cytosol\"", "Reactome:R-HSA-1369017 \"Activation of ATP sensitive Potassium channels in muscle cells\"", "Reactome:R-HSA-5678261 \"KCNJ11:ABCC9 transports K+ f...
[ "GO:0005249", "GO:0099094" ]
[]
[]
[]
[ "GO:0005249", "GO:0099094" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005243
5,243
gap junction channel activity
molecular_function
A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap ...
[ "GOC:dgh", "GOC:mtg_transport", "ISBN:0815340729" ]
null
[ "connexin", "innexin", "innexin channel activity", "intercellular channel" ]
[ "RELATED", "NARROW", "EXACT", "BROAD" ]
[ "GO:0015285", "GO:0015286" ]
[]
[ "Reactome:R-HSA-190681 \"Connexin oligomerization in endoplasmic reticulum membrane\"", "Reactome:R-HSA-375330 \"Connexin 45/Connexin 36 mediated neuronal gap junction communication\"", "Reactome:R-HSA-375339 \"Pannexin 1/Pannexin2 mediated neuronal gap junction communication\"", "Reactome:R-HSA-375340 \"Conn...
[ "GO:0022829" ]
[]
[]
[]
[ "GO:0022829" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0005244
5,244
voltage-gated monoatomic ion channel activity
molecular_function
Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded...
[ "GOC:mtg_transport", "ISBN:0198506732", "ISBN:0815340729" ]
null
[ "voltage gated ion channel activity", "voltage-dependent ion channel activity", "voltage-gated ion channel activity" ]
[ "EXACT", "EXACT", "BROAD" ]
[]
[]
[]
[ "GO:0005216", "GO:0022832" ]
[]
[]
[]
[ "GO:0005216", "GO:0022832" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24479\" xsd:anyURI" ]
null
null
false
true
5
GO:0005245
5,245
voltage-gated calcium channel activity
molecular_function
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
[ "GOC:mtg_transport", "GOC:tb", "ISBN:0815340729" ]
null
[ "depolarization-activated calcium channel", "depolarization-activated voltage gated calcium channel activity", "depolarization-activated voltage-gated calcium channel", "depolarization-activated voltage-gated calcium channel activity", "dihydropyridine-sensitive calcium channel activity", "voltage gated c...
[ "BROAD", "EXACT", "EXACT", "EXACT", "NARROW", "EXACT", "EXACT", "EXACT", "EXACT" ]
[ "GO:0010173", "GO:0015270" ]
[]
[ "Reactome:R-HSA-265645 \"Calcium Influx through Voltage-gated Calcium Channels\"", "Reactome:R-HSA-5577213 \"LTCC multimer transports Ca2+ from extracellular region to cytosol\"", "Reactome:R-HSA-9701055 \"TRPA1 tetramer transports Ca2+ from extracellular region to cytosol\"", "Reactome:R-HSA-9701141 \"TRPV1 ...
[ "GO:0005262", "GO:0022843" ]
[]
[]
[]
[ "GO:0005262", "GO:0022843" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0005247
5,247
voltage-gated chloride channel activity
molecular_function
Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
[ "GOC:mtg_transport", "ISBN:0815340729" ]
null
[ "voltage gated chloride channel activity", "voltage-dependent chloride channel activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[ "Reactome:R-HSA-2744228 \"CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region\"" ]
[ "GO:0005254", "GO:0008308" ]
[]
[]
[]
[ "GO:0005254", "GO:0008308" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0005248
5,248
voltage-gated sodium channel activity
molecular_function
Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
[ "GOC:mtg_transport", "ISBN:0815340729" ]
null
[ "voltage gated sodium channel activity", "voltage-dependent sodium channel activity", "voltage-gated sodium ion channel activity", "voltage-sensitive sodium channel" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[ "Reactome:R-HSA-5576895 \"SCNAs:SNCBs transport Na+ from extracellular region to cytosol\"" ]
[ "GO:0005272" ]
[]
[]
[]
[ "GO:0005272" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0005249
5,249
voltage-gated potassium channel activity
molecular_function
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
[ "GOC:mtg_transport", "ISBN:0815340729" ]
null
[ "voltage gated potassium channel activity", "voltage-dependent potassium channel activity", "voltage-gated potassium ion channel activity", "voltage-sensitive potassium channel" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[ "Reactome:R-HSA-1296127 \"Activation of voltage gated Potassium channels\"", "Reactome:R-HSA-9659554 \"KCNQ4 transports K+ from the cytosol to the extracellular region\"", "Reactome:R-HSA-9667761 \"KCNMA1:KCNMB1:LRRC52 transports K+ from the cytosol to the extracellular region\"" ]
[ "GO:0005267", "GO:0022843" ]
[]
[]
[]
[ "GO:0005267", "GO:0022843" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5