LiteFold/GO · Datasets at Hugging Face

GO:0005250

5,250

A-type (transient outward) potassium channel activity

molecular_function

Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential.

[ "GOC:mah", "PMID:5575340" ]

null

[]

[ "Reactome:R-HSA-5577234 \"KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region\"" ]

[ "GO:0015271" ]

[]

[ "GO:0015271" ]

[]

null

false

true

1

GO:0005251

5,251

delayed rectifier potassium channel activity

molecular_function

Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.

[ "GOC:mah", "PMID:11343411", "PMID:2462513" ]

null

[]

[ "Reactome:R-HSA-5577050 \"AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region\"", "Reactome:R-HSA-5577237 \"KCNH2:KCNE transport K+ from cytosol to extracellular region\"" ]

[ "GO:0005249" ]

[]

[ "GO:0005249" ]

[]

null

false

true

4

GO:0005252

5,252

open rectifier potassium channel activity

molecular_function

Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration.

[ "GOC:mah", "PMID:8917578" ]

null

[]

[ "GO:0005249" ]

[]

[ "GO:0005249" ]

[]

null

false

true

8

GO:0005253

5,253

monoatomic anion channel activity

molecular_function

Enables the energy-independent facilitated diffusion of a monoatomic anion through a transmembrane aqueous pore or channel.

[ "GOC:dph", "GOC:mtg_transport", "GOC:pr", "ISBN:0815340729" ]

null

[ "anion channel activity", "non-selective anion channel activity" ]

[ "BROAD", "NARROW" ]

[]

[ "Reactome:R-HSA-432034 \"Aquaporin-6 passively transports anions into vesicles\"", "Reactome:R-HSA-432036 \"Aquaporin-6 passively transports anions out of vesicles\"", "Reactome:R-HSA-9855161 \"Pannexin-1 (PANX1) channel transports ATP from the cytosol to the extracellular region\"" ]

[ "GO:0005216", "GO:0008509" ]

[]

[ "GO:0005216", "GO:0008509" ]

[]

[ "GO:0005261" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24479\" xsd:anyURI" ]

null

false

true

9

GO:0005260

5,260

intracellularly ATP-gated chloride channel activity

molecular_function

Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane.

[ "PMID:24727426", "PMID:9922375" ]

This activity is a phosphorylation and ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl-) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.This in contrast...

[ "CFTR", "channel-conductance-controlling ATPase activity", "cystic fibrosis transmembrane conductance regulator" ]

[ "EXACT", "RELATED", "NARROW" ]

[ "GO:0005224" ]

[]

[ "EC:5.6.1.6", "MetaCyc:3.6.3.49-RXN", "TC:3.A.1.202.1", "Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator" ]

[ "GO:0005254", "GO:0099095", "GO:0099142", "GO:0120544" ]

[]

[ "GO:0005254", "GO:0099095", "GO:0099142", "GO:0120544" ]

[]

[ "skos:exactMatch EC:5.6.1.6", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14402\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29690\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", ...

null

false

true

7

GO:0005262

5,262

calcium channel activity

molecular_function

Enables the energy-independent facilitated diffusion of a calcium ion through a transmembrane aqueous pore or channel.

[ "GOC:mtg_transport", "GOC:pr", "ISBN:0815340729" ]

null

[]

[ "Reactome:R-HSA-139854 \"IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol\"", "Reactome:R-HSA-139855 \"P2X1-mediated entry of Ca++ from plasma\"", "Reactome:R-HSA-210420 \"Ca2+ influx through voltage gated Ca2+ channels\"", "Reactome:R-HSA-3295579 \"TRPs transport ...

[ "GO:0005261", "GO:0015085" ]

[]

[ "GO:0005261", "GO:0015085" ]

[]

[ "skos:broadMatch RHEA:29671", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27521\" xsd:anyURI" ]

null

false

true

1

GO:0005267

5,267

potassium channel activity

molecular_function

Enables the energy-independent facilitated diffusion of a potassium ion through a transmembrane aqueous pore or channel.

[ "GOC:BHF", "GOC:mtg_transport", "GOC:pr", "ISBN:0815340729" ]

null

[]

[ "Reactome:R-HSA-1296024 \"Activation of ATP sensitive Potassium channels in neuroendocrine cells\"", "Reactome:R-HSA-1296035 \"Activation of Ca2+ activated Potassium channels with Intermediate conductance\"", "Reactome:R-HSA-1296037 \"Activation of Ca2+ activated Potassium channels with large conductance\"", ...

[ "GO:0005261", "GO:0015079" ]

[]

[ "GO:0005261", "GO:0015079" ]

[]

[ "skos:broadMatch RHEA:29463", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27521\" xsd:anyURI" ]

null

false

true

7

GO:0005272

5,272

sodium channel activity

molecular_function

Enables the energy-independent facilitated diffusion of a sodium ion through a transmembrane aqueous pore or channel.

[ "GOC:BHF", "GOC:mtg_transport", "GOC:pr", "ISBN:0815340729" ]

null

[]

[ "Reactome:R-HSA-2730664 \"UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol\"", "Reactome:R-HSA-3295580 \"TRPM4,5 transport extracellular Na+ to cytosol\"", "Reactome:R-HSA-9717374 \"SCN3A:SCN2B,4B transports Na+ from the extracellular region to the cytosol\"", "Reactome:R-HSA-9717382 \"SCN9A:S...

[ "GO:0005261", "GO:0015081" ]

[]

[ "GO:0005261", "GO:0015081" ]

[]

[ "skos:broadMatch RHEA:34963", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27521\" xsd:anyURI" ]

null

false

true

6

GO:0005274

5,274

allantoin:proton symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport.

[ "GOC:mtg_transport", "ISBN:0815340729", "TC:2.A.39.3.1" ]

null

[ "allantoin permease activity", "allantoin uptake transmembrane transporter activity", "allantoin/allantoate transporter" ]

[ "RELATED", "NARROW", "BROAD" ]

[ "GO:0015206" ]

[]

[ "GO:0015295" ]

[ "part_of GO:0015720" ]

[ "part_of" ]

[ "GO:0015720" ]

[ "GO:0015295", "GO:0015720" ]

[]

null

false

true

5

GO:0005275

5,275

amine transmembrane transporter activity

molecular_function

Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.

[ "GOC:mtg_transport", "ISBN:0198506732", "ISBN:0815340729" ]

null

[ "amine/amide/polyamine channel activity", "amine/polyamine transmembrane transporter activity", "amino acid-polyamine transmembrane transporter activity" ]

[ "BROAD", "EXACT", "EXACT" ]

[ "GO:0005279" ]

[]

[ "GO:0022857" ]

[ "part_of GO:0015837" ]

[ "part_of" ]

[ "GO:0015837" ]

[ "GO:0015837", "GO:0022857" ]

[]

null

false

true

9

GO:0005276

5,276

obsolete vesicular amino acid:proton antiporter activity

molecular_function

OBSOLETE. Enables the transfer of a solute or solutes from one side of a vesicle membrane to the other according to the reaction: H+(in) + amino acid(out) = H+(out) + amino acid(in).

[ "GOC:mah" ]

The reason for obsoletion is that the cellular component does not belong is the MF according to the documentation: http://wiki.geneontology.org/index.php/Transporter_terms_standard_definitions

[ "hydrogen:vesicular amine antiporter activity", "vesicular hydrogen:amino acid antiporter activity" ]

[ "EXACT", "EXACT" ]

[]

null

true

6

GO:0005277

5,277

acetylcholine transmembrane transporter activity

molecular_function

Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.

[ "GOC:ai" ]

null

[]

[ "Reactome:R-HSA-264615 \"Loading of acetylcholine in synaptic vesicles\"" ]

[ "GO:0005326", "GO:1901375" ]

[]

[ "GO:0005326", "GO:1901375" ]

[]

null

false

true

6

GO:0005278

5,278

acetylcholine:proton antiporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out).

[ "TC:2.A.1.2.13" ]

null

[ "acetylcholine:hydrogen antiporter activity" ]

[ "EXACT" ]

[]

[ "GO:0005277", "GO:0015078", "GO:0015297" ]

[]

[ "GO:0005277", "GO:0015078", "GO:0015297" ]

[]

null

false

true

5

GO:0005280

5,280

amino acid:proton symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in).

[ "GOC:ai" ]

null

[ "cation/amino acid symporter", "hydrogen:amino acid symporter activity" ]

[ "BROAD", "EXACT" ]

[]

[ "Reactome:R-HSA-8875623 \"SLC25A18,22 import L-Glu, H+\"" ]

[ "GO:0005416", "GO:0015295" ]

[]

[ "GO:0005416", "GO:0015295" ]

[]

null

false

true

8

GO:0005281

5,281

obsolete general amino acid permease activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it represents a gene product.

[ "general amino acid permease activity", "general amino acid transporter" ]

[ "EXACT", "BROAD" ]

[]

[ "GO:0015171" ]

[]

null

true

7

GO:0005283

5,283

amino acid:sodium symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in).

[ "GOC:ai" ]

null

[ "glutamate/aspartate:sodium symporter activity", "insulin-activated sodium/amino acid transporter activity", "insulin-activated sodium:amino acid symporter activity", "insulin-activated sodium:amino acid transporter activity", "isoleucine/valine:sodium symporter activity", "sodium/amino acid transporter a...

[ "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "BROAD", "BROAD", "EXACT", "EXACT", "BROAD", "NARROW" ]

[ "GO:0005284", "GO:0005285" ]

[]

[ "GO:0005416", "GO:0015370" ]

[]

[ "GO:0005416", "GO:0015370" ]

[]

null

false

true

2

GO:0005287

5,287

high-affinity basic amino acid transmembrane transporter activity

molecular_function

Enables the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.

[ "GOC:mtg_transport" ]

null

[ "high affinity basic amino acid transmembrane transporter activity", "high-affinity basic amino acid transporter activity" ]

[ "EXACT", "BROAD" ]

[]

[ "GO:0015174" ]

[]

[ "GO:0015174" ]

[]

null

false

true

3

GO:0005289

5,289

high-affinity L-arginine transmembrane transporter activity

molecular_function

Enables the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.

[ "GOC:mtg_transport" ]

null

[ "high affinity arginine transmembrane transporter activity", "high-affinity arginine transmembrane transporter activity", "high-affinity arginine transporter activity" ]

[ "EXACT", "EXACT", "BROAD" ]

[]

[ "GO:0005287", "GO:0061459" ]

[]

[ "GO:0005287", "GO:0061459" ]

[]

null

false

true

6

GO:0005291

5,291

high-affinity L-histidine transmembrane transporter activity

molecular_function

Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.

[ "GOC:mtg_transport" ]

null

[ "high affinity histidine permease activity", "high affinity L-histidine transmembrane transporter activity" ]

[ "RELATED", "EXACT" ]

[]

[ "GO:0005287", "GO:0005290" ]

[]

[ "GO:0005287", "GO:0005290" ]

[]

null

false

true

6

GO:0005292

5,292

high-affinity lysine transmembrane transporter activity

molecular_function

Enables the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.

[ "GOC:mtg_transport" ]

null

[ "high affinity lysine transmembrane transporter activity", "high affinity lysine transporter activity" ]

[ "EXACT", "BROAD" ]

[]

[ "GO:0005287", "GO:0015189" ]

[]

[ "GO:0005287", "GO:0015189" ]

[]

null

false

true

7

GO:0005294

5,294

neutral L-amino acid secondary active transmembrane transporter activity

molecular_function

Enables the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active t...

[ "GOC:mtg_transport" ]

null

[ "neutral L-amino acid porter activity" ]

[ "RELATED" ]

[]

[ "GO:0015175", "GO:0015291" ]

[]

[ "GO:0015175", "GO:0015291" ]

[]

null

false

true

5

GO:0005295

5,295

neutral L-amino acid:sodium symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) = neutral L-amino acid(in) + Na+(in).

[ "TC:2.A.23.3.1" ]

null

[ "neutral amino acid-sodium cotransporter", "neutral amino acid:sodium symporter activity", "sodium/neutral amino acid transporter" ]

[ "BROAD", "EXACT", "BROAD" ]

[ "GO:0005282" ]

[]

[ "GO:0005283", "GO:0015175" ]

[]

[ "GO:0005283", "GO:0015175" ]

[]

null

false

true

9

GO:0005297

5,297

proline:proton symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in).

[ "GOC:ai" ]

null

[ "hydrogen/proline transporter" ]

[ "BROAD" ]

[]

[ "GO:0005280", "GO:0046943" ]

[]

[ "GO:0005280", "GO:0046943" ]

[]

null

false

true

4

GO:0005298

5,298

proline:sodium symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in).

[ "TC:2.A.22.2.1" ]

null

[ "sodium/proline symporter activity" ]

[ "EXACT" ]

[]

[ "MetaCyc:TRANS-RXN-118", "Reactome:R-HSA-444100 \"PROT mediates L-proline uptake\"", "RHEA:28967" ]

[ "GO:0005283", "GO:0005343", "GO:0046943" ]

[]

[ "GO:0005283", "GO:0005343", "GO:0046943" ]

[]

[ "skos:exactMatch RHEA:28967", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26941\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

4

GO:0005300

5,300

high-affinity tryptophan transmembrane transporter activity

molecular_function

Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.

[ "GOC:mtg_transport", "ISBN:0815340729" ]

null

[ "high-affinity tryptophan transporter activity" ]

[ "BROAD" ]

[]

[ "GO:0015196" ]

[]

[ "GO:0015196" ]

[]

null

false

true

7

GO:0005301

5,301

obsolete valine/tyrosine/tryptophan permease activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it represents a multifunctional gene product.

[ "hydrogen/valine-tyrosine-tryptophan transporter", "valine/tyrosine/tryptophan permease activity" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0005302", "GO:0005304", "GO:0015196", "GO:0022857" ]

[]

null

true

7

GO:0005302

5,302

L-tyrosine transmembrane transporter activity

molecular_function

Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid.

[ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ]

null

[ "L-tyrosine permease activity", "L-tyrosine transporter activity", "valine/tyrosine/tryptophan permease activity" ]

[ "EXACT", "BROAD", "RELATED" ]

[ "GO:0015508" ]

[]

[ "GO:0015173", "GO:0015179" ]

[ "part_of GO:0015828" ]

[ "part_of" ]

[ "GO:0015828" ]

[ "GO:0015173", "GO:0015179", "GO:0015828" ]

[]

null

false

true

9

GO:0005304

5,304

L-valine transmembrane transporter activity

molecular_function

Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid.

[ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ]

null

[ "isoleucine/valine:sodium symporter activity", "L-valine transporter activity", "leucine/isoleucine/valine porter activity", "leucine/valine/isoleucine permease activity", "valine/tyrosine/tryptophan permease activity" ]

[ "NARROW", "BROAD", "NARROW", "NARROW", "NARROW" ]

[]

[ "GO:0015175", "GO:0015179", "GO:0015658" ]

[ "part_of GO:1903785" ]

[ "part_of" ]

[ "GO:1903785" ]

[ "GO:0015175", "GO:0015179", "GO:0015658", "GO:1903785" ]

[]

null

false

true

9

GO:0005307

5,307

choline:sodium symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in).

[ "TC:2.A.22.3.5" ]

null

[ "sodium/choline symporter activity" ]

[ "EXACT" ]

[]

[ "RHEA:76443" ]

[ "GO:0015220", "GO:0015370" ]

[]

[ "GO:0015220", "GO:0015370" ]

[]

[ "skos:exactMatch RHEA:76443", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27278\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

4

GO:0005308

5,308

creatine transmembrane transporter activity

molecular_function

Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.

[ "GOC:ai" ]

null

[]

[ "GO:0046943", "GO:0072349" ]

[ "part_of GO:0015881" ]

[ "part_of" ]

[ "GO:0015881" ]

[ "GO:0015881", "GO:0046943", "GO:0072349" ]

[]

null

false

true

3

GO:0005309

5,309

creatine:sodium symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in).

[ "TC:2.A.22.3.4" ]

null

[ "sodium/chloride-dependent creatine transporter" ]

[ "BROAD" ]

[]

[ "Reactome:R-HSA-200396 \"Creatine transport across the plasma membrane\"" ]

[ "GO:0005308", "GO:0005343" ]

[]

[ "GO:0005308", "GO:0005343" ]

[]

null

false

true

2

GO:0005310

5,310

dicarboxylic acid transmembrane transporter activity

molecular_function

Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups.

[ "GOC:ai" ]

null

[ "dicarboxylate (succinate/fumarate/malate) antiporter activity", "dicarboxylate carrier", "dicarboxylic acid permease activity", "sodium:dicarboxylate/tricarboxylate symporter activity" ]

[ "RELATED", "NARROW", "RELATED", "NARROW" ]

[ "GO:0005312", "GO:0015365" ]

[]

[ "Reactome:R-HSA-1614546 \"Sulfate is exported to the cytosol in exchange for dicarboxylate\"", "Reactome:R-HSA-372843 \"SLC25A10 mediates exchange of malate and phosphate\"" ]

[ "GO:0046943" ]

[ "part_of GO:0006835" ]

[ "part_of" ]

[ "GO:0006835" ]

[ "GO:0006835", "GO:0046943" ]

[]

null

false

true

9

GO:0005311

5,311

obsolete sodium:dicarboxylate/tricarboxylate symporter activity

molecular_function

OBSOLETE. Catalysis of the reaction: (dicarboxylate or tricarboxylate)(out) + Na+(out) = (dicarboxylate or tricarboxylate)(in) + Na+(in).

[ "TC:2.A.47.1.5" ]

This term was made obsolete because it represents a multifunctional gene product.

[ "sodium:dicarboxylate/tricarboxylate cotransporter activity", "sodium:dicarboxylate/tricarboxylate symporter activity" ]

[ "BROAD", "EXACT" ]

[]

[ "GO:0005310", "GO:0005343", "GO:0015142" ]

[]

null

true

9

GO:0005313

5,313

L-glutamate transmembrane transporter activity

molecular_function

Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.

[ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ]

null

[ "glutamate transmembrane transporter activity", "glutamate/aspartate porter activity", "glutamate/aspartate:sodium symporter activity", "L-glutamate transporter activity" ]

[ "BROAD", "NARROW", "NARROW", "BROAD" ]

[]

[ "Reactome:R-HSA-210444 \"L-Glutamate loading of synaptic vesicle\"", "Reactome:R-HSA-428052 \"SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+\"", "Reactome:R-HSA-5624256 \"Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+\"" ]

[ "GO:0015172", "GO:0015179" ]

[ "part_of GO:0015813" ]

[ "part_of" ]

[ "GO:0015813" ]

[ "GO:0015172", "GO:0015179", "GO:0015813" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27521\" xsd:anyURI" ]

null

false

true

4

GO:0005315

5,315

phosphate transmembrane transporter activity

molecular_function

Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transport...

[ "GOC:mtg_transport" ]

null

[ "inorganic phosphate transmembrane transporter activity" ]

[ "EXACT" ]

[ "GO:0005317", "GO:1901677" ]

[]

[ "Reactome:R-HSA-5226964 \"ANKH transports PPi from cytosol to extracellular region\"" ]

[ "GO:0015291" ]

[]

[ "GO:0015291" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27121\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27521\" xsd:anyURI" ]

null

false

true

2

GO:0005316

5,316

high-affinity phosphate:sodium symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction:phosphate(out) + Na+(out) = phosphate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.

[ "TC:2.A.20.2.2" ]

null

[ "high affinity inorganic phosphate:sodium symporter activity", "high-affinity inorganic phosphate:sodium symporter activity", "sodium/phosphate cotransporter activity" ]

[ "EXACT", "EXACT", "BROAD" ]

[]

[ "GO:0005436" ]

[]

[ "GO:0005436" ]

[]

null

false

true

9

GO:0005318

5,318

obsolete phosphate:hydrogen symporter

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:curators" ]

null

[ "phosphate:hydrogen symporter", "phosphate:proton symporter activity" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0015317" ]

[]

null

true

5

GO:0005319

5,319

lipid carrier activity

molecular_function

Directly binding to a specific lipid and delivering it either to an acceptor molecule or to a specific location.

[ "GOC:curators" ]

null

[ "apolipoprotein", "lipid transporter activity", "lipophorin" ]

[ "NARROW", "BROAD", "NARROW" ]

[]

[ "Reactome:R-HSA-1369028 \"ABCAs mediate lipid efflux\"", "Reactome:R-HSA-1369052 \"ABCAs mediate lipid influx\"", "Reactome:R-HSA-174786 \"ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex\"", "Reactome:R-HSA-5334794 \"FABPs bind LCFAs\"", "Reactome:R-HSA-5682285 \"ABCA12 transports li...

[ "GO:0140104" ]

[]

[ "GO:0140104" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31454\" xsd:anyURI" ]

null

false

true

3

GO:0005320

5,320

obsolete apolipoprotein

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it does not represent a molecular function.

[ "apolipoprotein" ]

[ "EXACT" ]

[ "GO:0015907" ]

[]

[ "GO:0005319" ]

[]

null

true

8

GO:0005321

5,321

obsolete high-density lipoprotein

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it does not represent a molecular function.

[ "HDL", "high-density lipoprotein" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0005319" ]

[]

null

true

5

GO:0005322

5,322

obsolete low-density lipoprotein

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it does not represent a molecular function.

[ "LDL", "low-density lipoprotein" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0005319" ]

[]

null

true

5

GO:0005323

5,323

obsolete very-low-density lipoprotein

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it does not represent a molecular function.

[ "very-low-density lipoprotein", "VLDL" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0005319" ]

[]

null

true

7

GO:0005324

5,324

long-chain fatty acid transmembrane transporter activity

molecular_function

Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.

[ "ISBN:0198506732" ]

While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).

[ "long-chain fatty acid transporter activity" ]

[ "RELATED" ]

[ "GO:0005325", "GO:0008562" ]

[]

[ "Reactome:R-HSA-2026996 \"FABP1 transports fatty acids into the nucleus\"", "Reactome:R-HSA-2046087 \"Translocation of tetracosahexaenoyl-CoA to peroxisomes\"", "Reactome:R-HSA-2046093 \"Translocation of tetracosapentaenoyl-CoA to peroxisomes\"", "Reactome:R-HSA-382575 \"ABCD1-3 dimers transfer LCFAs from cyt...

[ "GO:0015245" ]

[ "part_of GO:0015909" ]

[ "part_of" ]

[ "GO:0015909" ]

[ "GO:0015245", "GO:0015909" ]

[]

[ "skos:exactMatch RHEA:39283", "skos:narrowMatch RHEA:33655", "skos:narrowMatch RHEA:39807", "skos:narrowMatch RHEA:45252", "skos:narrowMatch RHEA:45256", "skos:narrowMatch RHEA:45264", "skos:narrowMatch RHEA:71395", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14793\" xsd:an...

null

false

true

1

GO:0005326

5,326

neurotransmitter transmembrane transporter activity

molecular_function

Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.

[ "GOC:ai", "ISBN:0198506732" ]

null

[ "neurotransmitter transporter activity" ]

[ "RELATED" ]

[]

[ "Reactome:R-HSA-374896 \"Uptake of Noradrenaline\"", "Reactome:R-HSA-374919 \"Noradrenaline clearance from the synaptic cleft\"" ]

[ "GO:0022857" ]

[ "part_of GO:0006836" ]

[ "part_of" ]

[ "GO:0006836" ]

[ "GO:0006836", "GO:0022857" ]

[]

null

false

true

8

GO:0005328

5,328

neurotransmitter:sodium symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in).

[ "TC:2.A.22.-.-" ]

null

[ "sodium/neurotransmitter symporter activity" ]

[ "EXACT" ]

[]

[ "GO:0005326", "GO:0015370" ]

[]

[ "GO:0005326", "GO:0015370" ]

[]

null

false

true

5

GO:0005330

5,330

dopamine:sodium symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in).

[ "PMID:21752877", "PMID:22519513", "TC:2.A.22.1.3" ]

null

[ "dopamine transmembrane transporter activity", "dopamine:sodium:chloride symporter activity", "sodium/dopamine symporter activity" ]

[ "EXACT", "EXACT", "EXACT" ]

[ "GO:0005329" ]

[]

[ "RHEA:70919", "RHEA:70931" ]

[ "GO:0008504", "GO:0015378" ]

[ "part_of GO:0090494" ]

[ "part_of" ]

[ "GO:0090494" ]

[ "GO:0008504", "GO:0015378", "GO:0090494" ]

[]

[ "skos:narrowMatch RHEA:70919", "skos:narrowMatch RHEA:70931", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/16054\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27278\" xsd:anyURI" ]

null

false

true

5

GO:0005332

5,332

gamma-aminobutyric acid:sodium:chloride symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in).

[ "PMID:7589472", "PMID:7861179" ]

See also the molecular function term 'neurotransmitter:sodium symporter activity ; GO:0005328'.

[ "4-aminobutanoate:sodium symporter activity", "4-aminobutyrate:sodium symporter activity", "betaine/GABA:sodium symporter activity", "GABA:sodium symporter activity", "gamma-aminobutyric acid:sodium symporter activity", "sodium/chloride-dependent GABA transporter activity" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "BROAD" ]

[]

[ "Reactome:R-HSA-444007 \"GAT1-3 mediate Na+/Cl- dependent GABA transport\"", "RHEA:70687", "RHEA:70731", "TC:2.A.22.3.2" ]

[ "GO:0005283", "GO:0015185", "GO:0015378", "GO:0140161" ]

[]

[ "GO:0005283", "GO:0015185", "GO:0015378", "GO:0140161" ]

[]

[ "skos:narrowMatch RHEA:70687", "skos:narrowMatch RHEA:70731", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23299\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27278\" xsd:anyURI" ]

null

false

true

3

GO:0005334

5,334

norepinephrine:sodium symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in).

[ "PMID:21752877", "PMID:22519513", "TC:2.A.22.1.2" ]

null

[ "levarterenol transporter activity", "noradrenaline transporter activity", "norepinephrine transmembrane transporter activity", "norepinephrine:sodium:chloride symporter activity", "sodium/norepinephrine symporter activity" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[ "GO:0005333" ]

[]

[ "Reactome:R-HSA-443997 \"SLC6A2 cotransports NAd, Na+,Cl- from extracellular region to cytosol\"", "Reactome:R-HSA-5659764 \"Defective SLC6A2 does not cotransport NAd, Na+ from extracellular region to cytosol\"", "Wikipedia:Norepinephrine_transporter" ]

[ "GO:0008504", "GO:0015378" ]

[ "part_of GO:0051620" ]

[ "part_of" ]

[ "GO:0051620" ]

[ "GO:0008504", "GO:0015378", "GO:0051620" ]

[]

null

false

true

1

GO:0005335

5,335

serotonin:sodium:chloride symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in).

[ "PMID:21752877", "PMID:22519513" ]

null

[ "serotonin transmembrane transporter activity", "serotonin:sodium symporter activity", "sodium/serotonin symporter activity" ]

[ "EXACT", "RELATED", "EXACT" ]

[ "GO:0005336", "GO:0015222" ]

[]

[ "Reactome:R-HSA-444008 \"SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol\"", "RHEA:51196", "TC:2.A.22.1.1" ]

[ "GO:0008504", "GO:0015378" ]

[ "part_of GO:0051610" ]

[ "part_of" ]

[ "GO:0051610" ]

[ "GO:0008504", "GO:0015378", "GO:0051610" ]

[]

[ "skos:exactMatch RHEA:51196", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23840\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

5

GO:0005337

5,337

nucleoside transmembrane transporter activity

molecular_function

Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other.

[ "GOC:ai" ]

null

[ "intracellular nucleoside transmembrane transporter activity" ]

[ "NARROW" ]

[]

[ "Reactome:R-HSA-109527 \"Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2\"", "Reactome:R-HSA-109529 \"Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2\"", ...

[ "GO:0015932", "GO:1901505" ]

[ "part_of GO:1901642" ]

[ "part_of" ]

[ "GO:1901642" ]

[ "GO:0015932", "GO:1901505", "GO:1901642" ]

[]

null

false

true

8

GO:0005338

5,338

nucleotide-sugar transmembrane transporter activity

molecular_function

Enables the transfer of a nucleotide-sugar from one side of a membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.

[ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729", "PMID:15034926" ]

null

[]

[ "GO:0005339" ]

[]

[ "Reactome:R-HSA-744230 \"SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP\"", "Reactome:R-HSA-744231 \"SLC35D2 exchanges UDP-GlcNAc for UMP\"", "Reactome:R-HSA-9792608 \"SLC35D2 exchanges UDP-D-glucose for UMP\"" ]

[ "GO:0015605", "GO:0015932", "GO:1901505" ]

[]

[ "GO:0015605", "GO:0015932", "GO:1901505" ]

[]

null

false

true

7

GO:0005342

5,342

obsolete organic acid transmembrane transporter activity

molecular_function

OBSOLETE. Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage.

[ "ISBN:0198506732" ]

The reason for obsoletion is that this term was an unnecessary and confusing grouping term.

[]

[ "GO:0022857" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30715\" xsd:anyURI" ]

null

true

6

GO:0005343

5,343

organic acid:sodium symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in).

[ "TC:2.A.28.1.1" ]

null

[ "sodium/chloride-dependent organic acid cotransporter activity", "sodium:dicarboxylate/tricarboxylate symporter activity" ]

[ "RELATED", "NARROW" ]

[]

[ "Reactome:R-HSA-8876312 \"SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol\"" ]

[ "GO:0015370" ]

[]

[ "GO:0015370" ]

[]

null

false

true

5

GO:0005344

5,344

oxygen carrier activity

molecular_function

Binding to oxygen and delivering it to an acceptor molecule or a specific location.

[ "GOC:ai" ]

null

[ "globin", "hemerythrin", "hemocyanin", "oxygen-carrying" ]

[ "NARROW", "NARROW", "NARROW", "NARROW" ]

[ "GO:0015033" ]

[]

[ "GO:0140104" ]

[ "has_part GO:0019825", "part_of GO:0015671" ]

[ "has_part", "part_of" ]

[ "GO:0019825", "GO:0015671" ]

[ "GO:0015671", "GO:0019825", "GO:0140104" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17399\" xsd:anyURI" ]

null

false

true

8

GO:0005345

5,345

purine nucleobase transmembrane transporter activity

molecular_function

Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other.

[ "ISBN:0198506732" ]

null

[ "purine base transmembrane transporter activity", "purine transmembrane transporter activity" ]

[ "EXACT", "RELATED" ]

[]

[ "GO:0015205" ]

[ "part_of GO:1904823" ]

[ "part_of" ]

[ "GO:1904823" ]

[ "GO:0015205", "GO:1904823" ]

[]

null

false

true

1

GO:0005346

5,346

purine ribonucleotide transmembrane transporter activity

molecular_function

Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other.

[ "GOC:ai" ]

null

[]

[ "GO:0015216", "GO:1901505" ]

[]

[ "GO:0015216", "GO:1901505" ]

[]

null

false

true

2

GO:0005350

5,350

pyrimidine nucleobase transmembrane transporter activity

molecular_function

Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other.

[ "GOC:ai" ]

null

[ "pyrimidine base transmembrane transporter activity", "pyrimidine transmembrane transporter activity" ]

[ "EXACT", "RELATED" ]

[]

[ "GO:0015205" ]

[ "part_of GO:0015855", "part_of GO:0072531" ]

[ "part_of", "part_of" ]

[ "GO:0015855", "GO:0072531" ]

[ "GO:0015205", "GO:0015855", "GO:0072531" ]

[]

null

false

true

1

GO:0005352

5,352

alpha-glucoside:proton symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.

[ "TC:2.A.1.1.11" ]

null

[ "alpha-glucoside:hydrogen symporter activity", "general alpha-glucoside transporter activity", "general alpha-glucoside:hydrogen symporter activity", "general alpha-glucoside:proton symporter activity" ]

[ "EXACT", "BROAD", "EXACT", "EXACT" ]

[]

[ "GO:0015151", "GO:0015295" ]

[]

[ "GO:0015151", "GO:0015295" ]

[]

null

false

true

2

GO:0005353

5,353

fructose transmembrane transporter activity

molecular_function

Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.

[ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ]

null

[ "fructose permease activity", "fructose porter activity" ]

[ "EXACT", "EXACT" ]

[ "GO:0015585", "GO:0019192" ]

[]

[ "Reactome:R-HSA-189222 \"SLC2A5 transports fructose from extracellular region to cytosol\"" ]

[ "GO:0015149" ]

[ "part_of GO:0015755" ]

[ "part_of" ]

[ "GO:0015755" ]

[ "GO:0015149", "GO:0015755" ]

[]

null

false

true

4

GO:0005354

5,354

galactose transmembrane transporter activity

molecular_function

Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.

[ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ]

null

[ "galactose/glucose (methylgalactoside) porter activity" ]

[ "RELATED" ]

[]

[ "GO:0015149" ]

[ "part_of GO:0015757" ]

[ "part_of" ]

[ "GO:0015757" ]

[ "GO:0015149", "GO:0015757" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24076\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27521\" xsd:anyURI" ]

null

false

true

4

GO:0005355

5,355

obsolete glucose transmembrane transporter activity

molecular_function

OBSOLETE. Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.

[ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ]

This term was obsoleted because it represents the same reaction as D-glucose transmembrane transporter activity ; GO:0055056.

[ "galactose/glucose (methylgalactoside) porter activity", "glucose permease activity", "glucose transmembrane transporter activity", "lactose/glucose efflux transporter activity" ]

[ "RELATED", "EXACT", "EXACT", "NARROW" ]

[]

[ "GO:0055056" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27326\" xsd:anyURI" ]

null

true

7

GO:0005356

5,356

D-glucose:proton symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a ti...

[ "GOC:mtg_transport" ]

null

[ "glucose:proton symporter activity", "hydrogen:glucose symporter activity", "hydrogen:glucose transporter activity", "transepithelial hydrogen/glucose transporter activity", "transepithelial hydrogen:glucose symporter activity", "transepithelial hydrogen:glucose transporter activity" ]

[ "EXACT", "EXACT", "RELATED", "RELATED", "NARROW", "RELATED" ]

[ "GO:0005361" ]

[]

[ "GO:0009679", "GO:0055056" ]

[]

[ "GO:0009679", "GO:0055056" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27326\" xsd:anyURI" ]

null

false

true

5

GO:0005357

5,357

obsolete constitutive glucose:proton symporter activity

molecular_function

OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mech...

[ "GOC:mtg_transport" ]

The reason for obsoletion is that the constitutive aspect of the transporter is unlikely to be an aspect of the activity, but instead it probably relates to the expression level of the transporter.

[ "constitutive hydrogen/glucose transporter activity", "constitutive hydrogen:glucose symporter activity", "constitutive hydrogen:glucose transporter activity" ]

[ "BROAD", "EXACT", "BROAD" ]

[]

null

true

6

GO:0005358

5,358

high-affinity D-glucose:proton symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism wher...

[ "GOC:mtg_transport" ]

null

[ "high-affinity glucose:proton symporter activity", "high-affinity hydrogen/glucose transporter activity", "high-affinity hydrogen:glucose symporter activity", "high-affinity hydrogen:glucose transporter activity" ]

[ "EXACT", "BROAD", "EXACT", "BROAD" ]

[]

[ "GO:0005356" ]

[]

[ "GO:0005356" ]

[]

null

false

true

4

GO:0005359

5,359

low-affinity D-glucose:proton symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active tra...

[ "GOC:mtg_transport" ]

null

[ "low-affinity glucose:proton symporter activity", "low-affinity hydrogen/glucose transporter activity", "low-affinity hydrogen:glucose symporter activity", "low-affinity hydrogen:glucose transporter activity" ]

[ "EXACT", "BROAD", "EXACT", "BROAD" ]

[]

[ "GO:0005356" ]

[]

[ "GO:0005356" ]

[]

null

false

true

1

GO:0005360

5,360

insulin-responsive D-glucose:proton symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species ar...

[ "GOC:mtg_transport" ]

null

[ "insulin-responsive glucose:proton symporter activity", "insulin-responsive hydrogen:glucose symporter activity", "insulin-responsive hydrogen:glucose transporter activity", "transepithelial hydrogen/glucose transporter activity" ]

[ "EXACT", "EXACT", "RELATED", "RELATED" ]

[]

[ "GO:0005356" ]

[]

[ "GO:0005356" ]

[]

null

false

true

1

GO:0005362

5,362

low-affinity D-glucose:sodium symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose(out) + Na+(out) = D-glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.

[ "TC:2.A.21.3.-" ]

null

[ "low-affinity glucose-sodium cotransporter activity", "low-affinity glucose:sodium symporter activity" ]

[ "BROAD", "EXACT" ]

[]

[ "Reactome:R-HSA-429567 \"Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4\"" ]

[ "GO:0005412" ]

[]

[ "GO:0005412" ]

[]

null

false

true

3

GO:0005364

5,364

maltose:proton symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in).

[ "TC:2.A.1.1.10" ]

null

[ "hydrogen/maltose transporter activity", "maltose permease", "maltose:hydrogen symporter activity" ]

[ "BROAD", "BROAD", "EXACT" ]

[]

[ "GO:0005351", "GO:0005363" ]

[]

[ "GO:0005351", "GO:0005363" ]

[]

null

false

true

9

GO:0005365

5,365

myo-inositol transmembrane transporter activity

molecular_function

Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms.

[ "GOC:ai" ]

null

[ "vitamin Bh transporter activity" ]

[ "EXACT" ]

[]

[ "Reactome:R-HSA-1855155 \"I(1,3,4,5,6)P5 transports from the ER lumen to the cytosol\"", "Reactome:R-HSA-1855164 \"IP6 transports from the cytosol to the ER lumen\"", "Reactome:R-HSA-1855186 \"I(1,3,4,5)P4 transports from the cytosol to the ER lumen\"", "Reactome:R-HSA-1855195 \"I(1,3,4,5,6)P5 transports from...

[ "GO:0015166" ]

[ "part_of GO:0015798" ]

[ "part_of" ]

[ "GO:0015798" ]

[ "GO:0015166", "GO:0015798" ]

[]

null

false

true

3

GO:0005366

5,366

myo-inositol:proton symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in).

[ "TC:2.A.1.1.8" ]

null

[ "hydrogen/myo-inositol transporter activity", "myo-inositol:hydrogen symporter activity" ]

[ "BROAD", "EXACT" ]

[]

[ "Reactome:R-HSA-429101 \"HMIT co-transports myo-inositol with a proton\"", "RHEA:60364" ]

[ "GO:0005365", "GO:0015295" ]

[]

[ "GO:0005365", "GO:0015295" ]

[]

[ "skos:exactMatch RHEA:60364", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

5

GO:0005367

5,367

myo-inositol:sodium symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in).

[ "TC:2.A.21.4.-" ]

null

[ "myo-inositol-sodium cotransporter activity" ]

[ "BROAD" ]

[]

[ "Reactome:R-HSA-429663 \"SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol\"" ]

[ "GO:0005365", "GO:0015370" ]

[]

[ "GO:0005365", "GO:0015370" ]

[]

null

false

true

2

GO:0005368

5,368

taurine transmembrane transporter activity

molecular_function

Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats.

[ "GOC:ai" ]

null

[]

[ "gocheck_do_not_annotate" ]

[]

[ "GO:1901682" ]

[ "part_of GO:0015734" ]

[ "part_of" ]

[ "GO:0015734" ]

[ "GO:0015734", "GO:1901682" ]

[]

null

false

true

8

GO:0005369

5,369

taurine:sodium symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in).

[ "TC:2.A.22.3.3" ]

null

[ "sodium/chloride-dependent taurine transporter" ]

[ "BROAD" ]

[]

[ "GO:0005343", "GO:0005368" ]

[]

[ "GO:0005343", "GO:0005368" ]

[]

null

false

true

9

GO:0005371

5,371

tricarboxylate secondary active transmembrane transporter activity

molecular_function

Enables the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transport...

[ "GOC:mtg_transport", "ISBN:0815340729" ]

null

[ "tricarboxylate carrier activity" ]

[ "EXACT" ]

[ "GO:0005370" ]

[]

[ "GO:0015291", "GO:0046943" ]

[]

[ "GO:0015291", "GO:0046943" ]

[]

null

false

true

2

GO:0005373

5,373

obsolete heavy metal ion porter activity

molecular_function

OBSOLETE. A transporter of heavy metal ions that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane.

[ "GOC:ai" ]

This term was made obsolete because it represents a gene product and not a molecular function.

[ "heavy metal ion porter activity", "metal ion transporter" ]

[ "EXACT", "BROAD" ]

[]

[ "GO:0015291", "GO:0046873" ]

[]

null

true

8

GO:0005375

5,375

copper ion transmembrane transporter activity

molecular_function

Enables the transfer of copper (Cu) ions from one side of a membrane to the other.

[ "GOC:ai" ]

null

[ "copper uptake transmembrane transporter activity", "intracellular copper ion transporter", "plasma membrane copper transporter" ]

[ "RELATED", "NARROW", "NARROW" ]

[ "GO:0005378", "GO:0005379", "GO:0005380", "GO:0015088" ]

[]

[ "Reactome:R-HSA-437300 \"SLC31A1 transports Cu1+ from extracellular region to cytosol\"" ]

[ "GO:0046915" ]

[ "part_of GO:0035434" ]

[ "part_of" ]

[ "GO:0035434" ]

[ "GO:0035434", "GO:0046915" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27521\" xsd:anyURI" ]

null

false

true

7

GO:0005376

5,376

obsolete plasma membrane copper transporter

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it contains both component and function information.

[ "plasma membrane copper transporter" ]

[ "EXACT" ]

[]

[ "GO:0005375", "GO:0005886" ]

[]

null

true

8

GO:0005377

5,377

obsolete intracellular copper ion transporter

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it contains both component and function information.

[ "intracellular copper ion transporter", "intracellular copper transporter" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0005375", "GO:0005622" ]

[]

null

true

5

GO:0005381

5,381

iron ion transmembrane transporter activity

molecular_function

Enables the transfer of iron (Fe) ions from one side of a membrane to the other.

[ "GOC:ai" ]

An example of this is mouse ferroportin (UniProtKB:Q9JHI9), which transports iron out of the cell.

[ "iron cation channel activity", "iron channel activity", "iron transporter activity", "multicopper ferroxidase iron transport mediator activity", "transmembrane iron ion permease activity", "transmembrane iron permease activity", "zinc, iron permease activity" ]

[ "EXACT", "EXACT", "EXACT", "RELATED", "EXACT", "EXACT", "RELATED" ]

[ "GO:0005382", "GO:0016033", "GO:0097689" ]

[]

[ "Reactome:R-HSA-435349 \"SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol\"", "Reactome:R-HSA-5623558 \"Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol\"", "Reactome:R-HSA-5655733 \"Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular reg...

[ "GO:0046915" ]

[ "part_of GO:0034755" ]

[ "part_of" ]

[ "GO:0034755" ]

[ "GO:0034755", "GO:0046915" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17162\" xsd:anyURI" ]

null

false

true

1

GO:0005384

5,384

manganese ion transmembrane transporter activity

molecular_function

Enables the transfer of manganese (Mn) ions from one side of a membrane to the other.

[ "GOC:dgf" ]

null

[]

[ "MetaCyc:RXN0-16", "Reactome:R-HSA-8959798 \"SLC30A10 transports Mn2+ from cytosol to extracellular region\"" ]

[ "GO:0046915" ]

[ "part_of GO:0071421" ]

[ "part_of" ]

[ "GO:0071421" ]

[ "GO:0046915", "GO:0071421" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26941\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27521\" xsd:anyURI" ]

null

false

true

5

GO:0005385

5,385

zinc ion transmembrane transporter activity

molecular_function

Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.

[ "GOC:dgf" ]

null

[ "cobalt, zinc uptake permease activity", "zinc, cadmium uptake permease activity", "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity", "zinc, iron permease activity" ]

[ "RELATED", "RELATED", "RELATED", "NARROW" ]

[]

[ "MetaCyc:RXN0-12", "Reactome:R-HSA-435366 \"ZnT1 mediates the efflux of zinc from the cell\"", "Reactome:R-HSA-435375 \"ZnT2 facilitates zinc vesicular sequestration\"", "Reactome:R-HSA-437084 \"ZnT3 transports zinc into synaptic vesicles\"", "Reactome:R-HSA-437085 \"ZnT5 transports zinc into secretory gran...

[ "GO:0046915" ]

[ "part_of GO:0071577" ]

[ "part_of" ]

[ "GO:0071577" ]

[ "GO:0046915", "GO:0071577" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26941\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27521\" xsd:anyURI" ]

null

false

true

1

GO:0005388

5,388

P-type calcium transporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out).

[ "RHEA:18105" ]

null

[ "ATP-dependent calcium transmembrane transporter activity", "ATPase-coupled calcium transmembrane transporter activity", "Ca(2+)-transporting ATPase activity", "Ca2+-transporting ATPase activity", "calcium efflux ATPase", "calcium pump", "calcium transmembrane transporter activity, phosphorylative mecha...

[ "EXACT", "RELATED", "RELATED", "RELATED", "NARROW", "BROAD", "EXACT", "EXACT", "NARROW", "EXACT", "NARROW" ]

[]

[ "EC:7.2.2.10", "MetaCyc:TRANS-RXN-194", "Reactome:R-HSA-418309 \"ATP2B1-4 transport cytosolic Ca2+ to extracellular region\"", "Reactome:R-HSA-418365 \"ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen\"", "Reactome:R-HSA-427910 \"ATP2A1-3 transport Ca2+ from cytosol to ER lumen\"", "Reacto...

[ "GO:0015085", "GO:0015662", "GO:0019829" ]

[]

[ "GO:0015085", "GO:0015662", "GO:0019829" ]

[]

[ "skos:exactMatch EC:7.2.2.10", "skos:exactMatch RHEA:18105", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26941\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

1

GO:0005391

5,391

P-type sodium:potassium-exchanging transporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).

[ "EC:7.2.2.13" ]

null

[ "Na(+)/K(+)-ATPase activity", "Na(+)/K(+)-exchanging ATPase activity", "Na+,K+-ATPase activity", "Na+/K+-ATPase activity", "Na+/K+-exchanging ATPase activity", "Na,K-activated ATPase activity", "P-type sodium:potassium-exchanging ATPase activity", "sodium pump", "sodium/potassium-exchanging ATPase a...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "BROAD", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "EC:7.2.2.13", "MetaCyc:3.6.3.9-RXN", "Reactome:R-HSA-936897 \"ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+\"", "RHEA:18353", "TC:3.A.3.1.1", "Wikipedia:ATPase\\,_Na%2B/K%2B_transporting\\,_alpha_1" ]

[ "GO:0008554", "GO:0008556" ]

[ "part_of GO:0010248" ]

[ "part_of" ]

[ "GO:0010248" ]

[ "GO:0008554", "GO:0008556", "GO:0010248" ]

[]

[ "skos:exactMatch EC:7.2.2.13", "skos:exactMatch RHEA:18353", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17289\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

3

GO:0005395

5,395

obsolete eye pigment precursor transporter activity

molecular_function

OBSOLETE. Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out).

[ "TC:3.A.1.204.1" ]

This term has been obsoleted because eye pigment precursors are nucleotides and amino acids, and there are terms to annotate these functions.

[]

null

true

5

GO:0005396

5,396

obsolete transmembrane conductance regulator activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:jl" ]

This term was made obsolete because its meaning was ambiguous, it was undefined and its position in the tree wrong.

[ "transmembrane conductance regulator activity" ]

[ "EXACT" ]

[]

[ "GO:0043267" ]

[]

null

true

8

GO:0005400

5,400

obsolete peroxisomal membrane transporter

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it contains both component and function information.

[ "peroxisomal membrane transporter" ]

[ "EXACT" ]

[]

[ "GO:0005215", "GO:0005777" ]

[]

null

true

3

GO:0005402

5,402

carbohydrate:monoatomic cation symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in).

[ "GOC:ai" ]

null

[ "carbohydrate:cation symporter activity", "cation/sugar symporter activity", "cation:sugar symporter activity", "sugar:cation symporter activity" ]

[ "BROAD", "EXACT", "EXACT", "NARROW" ]

[]

[ "GO:0015144", "GO:0015294" ]

[]

[ "GO:0015144", "GO:0015294" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24479\" xsd:anyURI" ]

null

false

true

5

GO:0005412

5,412

D-glucose:sodium symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose(out) + Na+(out) = D-glucose(in) + Na+(in).

[ "TC:2.A.21.3.-" ]

null

[ "glucose:sodium symporter activity", "sodium/glucose symporter activity" ]

[ "EXACT", "EXACT" ]

[]

[ "MetaCyc:RXN-22596", "Reactome:R-HSA-189208 \"SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol\"", "Reactome:R-HSA-429613 \"SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol\"", "Reactome:R-HSA-5656356 \"Defective SLC5A1 does not cotransport Glc and Na+\"", ...

[ "GO:0005402", "GO:0015370", "GO:0055056" ]

[]

[ "GO:0005402", "GO:0015370", "GO:0055056" ]

[]

[ "skos:narrowMatch RHEA:70495", "skos:narrowMatch RHEA:70571", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27278\" xsd:anyURI" ]

null

false

true

8

GO:0005415

5,415

nucleoside:sodium symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in).

[ "GOC:ai" ]

null

[ "nucleoside-sodium cotransporter activity", "sodium-dependent nucleoside transporter activity" ]

[ "BROAD", "BROAD" ]

[ "GO:0008522" ]

[]

[ "Reactome:R-HSA-109530 \"Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1\"", "Reactome:R-HSA-109538 \"Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nu...

[ "GO:0005337", "GO:0015370" ]

[]

[ "GO:0005337", "GO:0015370" ]

[]

null

false

true

7

GO:0005416

5,416

amino acid:monoatomic cation symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in).

[ "GOC:ai" ]

null

[ "amino acid:cation symporter activity", "cation/amino acid symporter activity", "cation:amino acid symporter activity" ]

[ "BROAD", "EXACT", "EXACT" ]

[]

[ "GO:0015171", "GO:0015294" ]

[]

[ "GO:0015171", "GO:0015294" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24479\" xsd:anyURI" ]

null

false

true

1

GO:0005427

5,427

proton-dependent oligopeptide secondary active transmembrane transporter activity

molecular_function

Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement.

[ "GOC:mtg_transport", "OMIM:600544" ]

null

[ "hydrogen/oligopeptide symporter", "proton-dependent oligopeptide transporter activity" ]

[ "RELATED", "EXACT" ]

[]

[ "GO:0015291" ]

[]

[ "GO:0015291" ]

[]

null

false

true

2

GO:0005429

5,429

obsolete chromaffin granule amine transmembrane transporter activity

molecular_function

OBSOLETE. Enables the transfer of amines across chromaffin granule membranes.

[ "GOC:mah" ]

The term was obsoleted because its intended usage was unclear: chromaffin granules are dense core secretory vesicles (PMID:20853344) so whatever they transport must be by secretion.

[]

null

true

1

GO:0005436

5,436

sodium:phosphate symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in).

[ "TC:2.A.1.14.6" ]

null

[ "sodium-dependent phosphate transmembrane transporter activity", "sodium/phosphate symporter activity" ]

[ "RELATED", "EXACT" ]

[ "GO:0015321" ]

[]

[ "Reactome:R-HSA-2872498 \"SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol\"", "Reactome:R-HSA-427605 \"SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol\"", "Reactome:R-HSA-427645 \"SLC34A3 cotransports Pi, 2Na+\"", "Reactome:R-HSA-427656 \"SLC34A1,2 cotransports Pi, 3Na+ from extr...

[ "GO:0005315", "GO:0015370" ]

[]

[ "GO:0005315", "GO:0015370" ]

[]

[ "skos:narrowMatch RHEA:71255", "skos:narrowMatch RHEA:71259", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18577\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23132\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-onto...

null

false

true

7

GO:0005451

5,451

obsolete monoatomic cation:proton antiporter activity

molecular_function

OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + H+(in) = monoatomic cation(in) + H+(out).

[ "GOC:ai" ]

This term was obsoleted because it represents an unnecessary grouping term.

[ "monovalent cation:hydrogen antiporter activity", "monovalent cation:proton antiporter activity" ]

[ "EXACT", "RELATED" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22962\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24479\" xsd:anyURI" ]

null

true

6

GO:0005452

5,452

solute:inorganic anion antiporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out).

[ "GOC:mah" ]

null

[ "inorganic anion exchanger activity" ]

[ "EXACT" ]

[]

[ "Reactome:R-HSA-1237038 \"SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-\"", "Reactome:R-HSA-1247665 \"SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-\"", "Reactome:R-HSA-425482 \"SLC4A1,2,3 exchanges HCO3- for Cl-\"", "Reactome:R-HSA-425577 \"Na+-driven Cl-/HCO3- exchanger transport\"", "Rea...

[ "GO:0015297" ]

[]

[ "GO:0015297" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23379\" xsd:anyURI" ]

null

false

true

7

GO:0005456

5,456

CMP-N-acetylneuraminate transmembrane transporter activity

molecular_function

Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other.

[ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ]

null

[ "CMP-sialic acid transmembrane transporter activity" ]

[ "BROAD" ]

[]

[ "Reactome:R-HSA-5651942 \"Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP\"", "Reactome:R-HSA-727807 \"SLC35A1 exchanges CMP-Neu5Ac for CMP\"" ]

[ "GO:0015165" ]

[ "part_of GO:0015782" ]

[ "part_of" ]

[ "GO:0015782" ]

[ "GO:0015165", "GO:0015782" ]

[]

null

false

true

4

GO:0005457

5,457

GDP-fucose transmembrane transporter activity

molecular_function

Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate.

[ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ]

null

[]

[ "Reactome:R-HSA-5653596 \"Defective SLC35C1 does not transport UDP-Fuc from cytosol to Golgi lumen\"", "Reactome:R-HSA-742345 \"SLC35C1 transport GDP-Fuc from cytosol to Golgi lumen\"" ]

[ "GO:0036080" ]

[ "part_of GO:0015783" ]

[ "part_of" ]

[ "GO:0015783" ]

[ "GO:0015783", "GO:0036080" ]

[]

null

false

true

2

GO:0005458

5,458

GDP-mannose transmembrane transporter activity

molecular_function

Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate.

[ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ]

null

[]

[ "GO:0036080" ]

[ "part_of GO:1990570" ]

[ "part_of" ]

[ "GO:1990570" ]

[ "GO:0036080", "GO:1990570" ]

[]

null

false

true

7

GO:0005459

5,459

UDP-galactose transmembrane transporter activity

molecular_function

Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate.

[ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ]

null

[]

[ "Reactome:R-HSA-5652099 \"Defective SLC35A2 does not exchange UDP-Gal, UDP-GalNAc for UMP\"", "Reactome:R-HSA-735702 \"SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP\"" ]

[ "GO:0015165" ]

[ "part_of GO:0072334" ]

[ "part_of" ]

[ "GO:0072334" ]

[ "GO:0015165", "GO:0072334" ]

[]

null

false

true

2

GO:0005460

5,460

UDP-glucose transmembrane transporter activity

molecular_function

Enables the transfer of a UDP-glucose from one side of a membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate.

[ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ]

null

[]

[ "GO:0015165" ]

[ "part_of GO:0015786" ]

[ "part_of" ]

[ "GO:0015786" ]

[ "GO:0015165", "GO:0015786" ]

[]

null

false

true

9