LiteFold/GO · Datasets at Hugging Face

GO:0120561

120,561

phosphatidylinositol lysophospholipase A1 activity

molecular_function

Catalysis of the reaction: a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = sn-glycero-3-phospho-1D-myo-inositol + a fatty acid + H+.

[ "RHEA:32987" ]

null

[ "phosphatidylinositol lysophospholipase A1-type activity" ]

[ "EXACT" ]

[]

[ "RHEA:32987", "RHEA:44588" ]

[ "GO:0120558" ]

[]

[ "GO:0120558" ]

[]

[ "skos:exactMatch RHEA:32987", "skos:narrowMatch RHEA:44588", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30258\" xsd:anyURI" ]

sjm

2025-05-23T13:15:46Z

false

true

1

GO:0120562

120,562

GlcNAc(2)-PP-Dol mannosyltransferase activity

molecular_function

Catalysis of the transfer of a mannosyl residue to GlcNAc(2)-PP-Dol bearing 0-8 mannoses during synthesis of the N-glycan precursor.

[ "GOC:curators" ]

null

[]

[ "gocheck_do_not_annotate" ]

[]

[ "GO:0000030" ]

[]

[ "GO:0000030" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30326\" xsd:anyURI" ]

sjm

2025-05-28T07:19:38Z

false

true

6

GO:0120564

120,564

dol-P-Man:Man(2)GlcN-acyl-PI alpha-1,2-mannosyltransferase activity

molecular_function

Catalysis of the transfer of an alpha-D-mannosyl residue from dolichol-P-mannose to Man(2)-GlcN-acyl-PI, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. This transfers the third mannose to the GPI precursor.

[ "PMID:8861954" ]

null

[ "glycosylphosphatidylinositol-mannosyltransferase III activity", "GPI-MT-III activity" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0000026", "GO:0004376" ]

[]

[ "GO:0000026", "GO:0004376" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30326\" xsd:anyURI" ]

sjm

2025-05-28T07:46:30Z

false

true

5

GO:0120565

120,565

dol-P-Man:Man(3)GlcN-acyl-PI alpha-1,2-mannosyltransferase activity

molecular_function

Catalysis of the transfer of an alpha-D-mannosyl residue from dolichol-P-mannose to Man(3)-GlcN-acyl-PI, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. This transfers a fourth mannose to the GPI precursor, which is only present in some organisms/cell types.

[ "PMID:15208306" ]

null

[ "glycosylphosphatidylinositol-mannosyltransferase IV activity", "GPI-MT-IV activity" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0000026", "GO:0004376" ]

[]

[ "GO:0000026", "GO:0004376" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30326\" xsd:anyURI" ]

sjm

2025-05-28T07:49:43Z

false

true

9

GO:0120566

120,566

menadiol geranylgeranyltransferase activity

molecular_function

Catalysis of the reaction: menadiol + (2E,6E,10E)-geranylgeranyl diphosphate = menaquinol-4 + diphosphate.

[ "PMID:20953171", "RHEA:74083" ]

null

[]

[ "MetaCyc:RXN-19669", "RHEA:74083" ]

[ "GO:0004659" ]

[]

[ "GO:0004659" ]

[]

[ "skos:exactMatch RHEA:74083", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30566\" xsd:anyURI" ]

sjm

2025-07-14T12:21:33Z

false

true

3

GO:0120567

120,567

hydroxytrimethyllysine aldolase activity

molecular_function

Catalysis of the reaction: (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine = 4-(trimethylamino)butanal + glycine.

[ "PMID:38615009", "RHEA:79695" ]

null

[ "HTMLA" ]

[ "EXACT" ]

[]

[ "MetaCyc:RXN-9896", "RHEA:79695" ]

[ "GO:0016832" ]

[]

[ "GO:0016832" ]

[]

[ "skos:broadMatch EC:2.1.2.1", "skos:exactMatch MetaCyc:RXN-9896", "skos:exactMatch RHEA:79695", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30653\" xsd:anyURI" ]

sjm

2025-07-30T15:06:39Z

false

true

2

GO:0120568

120,568

(R)-2-hydroxyglutarate (NAD+) dehydrogenase activity

molecular_function

Catalysis of the reaction: (R)-2-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH + H+.

[ "PMID:26774271", "RHEA:49612" ]

null

[ "2-oxoglutarate reductase activity" ]

[ "BROAD" ]

[]

[ "EC:1.1.1.399", "MetaCyc:KETOGLUTREDUCT-RXN", "RHEA:49612" ]

[ "GO:0016616", "GO:0051990" ]

[]

[ "GO:0016616", "GO:0051990" ]

[]

[ "skos:exactMatch EC:1.1.1.399", "skos:exactMatch MetaCyc:KETOGLUTREDUCT-RXN", "skos:exactMatch RHEA:49612", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30833\" xsd:anyURI" ]

sjm

2025-09-11T11:32:12Z

false

true

2

GO:0120569

120,569

phospholipase activity

molecular_function

Catalysis of the hydrolysis of a phospholipid.

[ "PMID:30109646" ]

null

[]

[ "GO:0016298" ]

[]

[ "GO:0016298" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31030\" xsd:anyURI" ]

sjm

2025-11-21T11:27:46Z

false

true

4

GO:0120570

120,570

sphingophospholipase activity

molecular_function

Catalysis of the hydrolysis of a sphingophospholipid.

[ "GOC:curators" ]

null

[]

[ "GO:0120569" ]

[]

[ "GO:0120569" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31030\" xsd:anyURI" ]

sjm

2025-11-21T11:32:06Z

false

true

1

GO:0120571

120,571

dihydrolipoyllysine-residue glutaryltransferase activity

molecular_function

Catalysis of the reaction: N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + glutaryl-CoA = CoA + N6-[(R)-S8-glutaryldihydrolipoyl]-L-lysyl-[protein].

[ "PMID:29191460" ]

null

[]

[ "GO:0016417" ]

[]

[ "GO:0016417" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31280\" xsd:anyURI" ]

sjm

2026-01-07T15:48:37Z

false

true

4

GO:0120572

120,572

L-lactate oxidase activity

molecular_function

Catalysis of the reaction: (S)-lactate + O2 = pyruvate + H2O2.

[ "PMID:34555022", "PMID:8589073", "RHEA:55868" ]

null

[]

[ "KEGG_REACTION:R11996", "MetaCyc:LACTATE-2-MONOOXYGENASE-RXN", "RHEA:55868" ]

[ "GO:0003973" ]

[]

[ "GO:0003973" ]

[]

[ "skos:exactMatch KEGG_REACTION:R11996", "skos:exactMatch MetaCyc:LACTATE-2-MONOOXYGENASE-RXN", "skos:exactMatch RHEA:55868", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30905#issuecomment-3389060260\" xsd:anyURI" ]

sjm

2026-01-20T09:45:52Z

false

true

3

GO:0120573

120,573

FAHFA hydrolase activity

molecular_function

Catalysis of the hydrolysis of the ester bond in a fatty acid ester of a hydroxy fatty acid (FAHFA), yielding a free fatty acid and a hydroxy fatty acid. FAHFAs are a class of endogenous bioactive signaling lipids in which a fatty acid is esterified to a hydroxyl group on a second fatty acid backbone.

[ "PMID:27018888", "PMID:32152231" ]

null

[ "fatty-acid ester of hydroxy-fatty-acid hydrolase activity" ]

[ "EXACT" ]

[]

[ "RHEA:52048", "RHEA:52052", "RHEA:52056", "RHEA:52060", "RHEA:52064", "RHEA:52068", "RHEA:52072", "RHEA:52076", "RHEA:52080", "RHEA:52084", "RHEA:52092", "RHEA:52096" ]

[ "GO:0052689" ]

[]

[ "GO:0052689" ]

[]

[ "skos:narrowMatch RHEA:52048", "skos:narrowMatch RHEA:52052", "skos:narrowMatch RHEA:52056", "skos:narrowMatch RHEA:52060", "skos:narrowMatch RHEA:52064", "skos:narrowMatch RHEA:52068", "skos:narrowMatch RHEA:52072", "skos:narrowMatch RHEA:52076", "skos:narrowMatch RHEA:52080", "skos:narrowMatch R...

sjm

2026-03-13T16:05:52Z

false

true

6

GO:0120575

120,575

L-dopa catabolic process

biological_process

The chemical reactions and pathways resulting in the breakdown of L-dopa.

[ "MetaCyc:PWY-6334", "MetaCyc:PWY-8110" ]

null

[]

[ "MetaCyc:PWY-6334", "MetaCyc:PWY-8110" ]

[ "GO:0009074", "GO:0042219", "GO:0170035", "GO:0170044", "GO:1903184" ]

[]

[ "GO:0009074", "GO:0042219", "GO:0170035", "GO:0170044", "GO:1903184" ]

[]

[ "skos:narrowMatch MetaCyc:PWY-6334", "skos:narrowMatch MetaCyc:PWY-8110", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31703\" xsd:anyURI" ]

sjm

2026-03-24T16:54:04Z

false

true

8

GO:0140001

140,001

morula formation

biological_process

The initial formation of a spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum.

[ "PMID:37935903", "PMID:38386558", "PMID:39361745" ]

null

[]

[ "GO:0048646" ]

[]

[ "GO:0048646" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29162\" xsd:anyURI" ]

pg

2024-11-12T09:29:56Z

false

true

6

GO:0140002

140,002

histone H3K4me3 reader activity

molecular_function

A histone reader that recognizes a histone H3 trimethylated at lysine 4.

[ "PMID:15647753", "PMID:23318260" ]

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...

[ "H3-K4me3 modified histone binding", "H3K4me3 modified histone binding" ]

[ "NARROW", "NARROW" ]

[]

[ "GO:0140006" ]

[]

[ "GO:0140006" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29384\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]

pg

2024-11-29T14:13:16Z

false

true

3

GO:0140003

140,003

histone H3K36me3 reader activity

molecular_function

A histone reader that recognizes a histone H3 trimethylated at lysine 36.

[ "PMID:15489290", "PMID:16364921" ]

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...

[ "H3-K36me3 modified histone binding", "H3K36me3 modified histone binding" ]

[ "NARROW", "NARROW" ]

[]

[ "GO:0140006" ]

[]

[ "GO:0140006" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29337\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]

pg

2024-11-29T14:20:22Z

false

true

7

GO:0140005

140,005

histone H4K20me2 reader activity

molecular_function

A histone reader that recognizes a histone H4 dimethylated at lysine 20.

[ "PMID:22150589" ]

Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.

[ "H4K20me2 modified histone binding" ]

[ "NARROW" ]

[]

[ "GO:0140008" ]

[]

[ "GO:0140008" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24912\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]

pg

2024-11-29T15:16:39Z

false

true

9

GO:0140006

140,006

histone H3 reader activity

molecular_function

A histone reader that specifically binds either to an unmodified histone H3 or a form modified by a post-translational modification on a specific residue. The most common PTMs on histones are methylation, acetylation and phosphorylation.

[ "PMID:11498575", "PMID:25688442", "PMID:31082667", "PMID:34726351" ]

null

[]

[ "GO:0140566" ]

[]

[ "GO:0140566" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27427\" xsd:anyURI" ]

pg

2024-12-06T13:03:19Z

false

true

2

GO:0140007

140,007

KICSTOR complex

cellular_component

A protein complex that regulates the TORC1 signaling pathway in response to nutrients. The KICSTOR complex is composed of KPTN, ITFG2, C12orf66 and SZT2.

[ "PMID:28199306" ]

null

[]

[ "GO:0032991" ]

[]

[ "GO:0032991" ]

[]

pg

2017-03-10T12:47:30Z

false

true

4

GO:0140008

140,008

histone H4 reader activity

molecular_function

A histone reader that specifically binds either to an unmodified histone H4 or a form modified by a post-translational modification on a specific residue. The most common PTMs on histones are methylation, acetylation and phosphorylation.

[ "PMID:11498575", "PMID:25688442", "PMID:31082667", "PMID:34726351" ]

null

[]

[ "GO:0140566" ]

[]

[ "GO:0140566" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29384\" xsd:anyURI" ]

pg

2024-12-06T13:09:47Z

false

true

6

GO:0140009

140,009

L-aspartate import across plasma membrane

biological_process

The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol.

[ "GO_REF:0000069", "PMID:7914198" ]

null

[]

[ "GO:0070778", "GO:0089718" ]

[]

[ "GO:0070778", "GO:0089718" ]

[]

pg

2017-03-13T10:59:51Z

false

true

6

GO:0140010

140,010

D-aspartate transmembrane transporter activity

molecular_function

Enables the transfer of D-aspartate from one side of a membrane to the other.

[ "GO_REF:0000070", "PMID:7914198" ]

null

[]

[ "GO:0005310", "GO:0015556", "GO:0042943" ]

[ "part_of GO:0070777" ]

[ "part_of" ]

[ "GO:0070777" ]

[ "GO:0005310", "GO:0015556", "GO:0042943", "GO:0070777" ]

[]

pg

2017-03-13T11:15:15Z

false

true

9

GO:0140011

140,011

histone H4K12ac reader activity

molecular_function

A histone reader that recognizes a histone H4 acetylated at lysine 12.

[ "PMID:14731392" ]

Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.

[ "H4K12ac modified histone binding" ]

[ "NARROW" ]

[]

[ "GO:0140008" ]

[]

[ "GO:0140008" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29384\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]

pg

2024-12-06T15:08:12Z

false

true

2

GO:0140012

140,012

histone H4K5ac reader activity

molecular_function

A histone reader that recognizes a histone H4 acetylated at lysine 5.

[ "PMID:18406326", "PMID:20709061" ]

Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.

[ "H4K5ac modified histone binding" ]

[ "NARROW" ]

[]

[ "GO:0140008" ]

[]

[ "GO:0140008" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29384\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]

pg

2024-12-06T15:38:06Z

false

true

5

GO:0140013

140,013

meiotic nuclear division

biological_process

One of the two nuclear divisions that occur as part of the meiotic cell cycle.

[ "PMID:9334324" ]

null

[ "meiosis" ]

[ "EXACT" ]

[]

[ "goslim_generic" ]

[]

[ "GO:0000280", "GO:1903046" ]

[]

[ "GO:0000280", "GO:1903046" ]

[ "GO:0000280", "part_of GO:0051321" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19910\" xsd:anyURI" ]

pg

2017-03-23T09:40:00Z

false

true

7

GO:0140015

140,015

histone H3K14ac reader activity

molecular_function

A histone reader that recognizes a histone H3 acetylated at lysine 14.

[ "PMID:30110338" ]

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...

[ "histone H3K14ac modified histone binding" ]

[ "NARROW" ]

[]

[ "GO:0140006" ]

[]

[ "GO:0140006" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29384\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]

pg

2024-12-06T15:39:27Z

false

true

2

GO:0140017

140,017

histone H3K18cr reader activity

molecular_function

A histone reader that recognizes a histone H3 crotonylated at lysine 18.

[ "PMID:27105114" ]

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...

[ "H3K18cr modified histone binding" ]

[ "NARROW" ]

[]

[ "GO:0140006" ]

[]

[ "GO:0140006" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29384\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]

pg

2024-12-06T15:41:32Z

false

true

8

GO:0140018

140,018

regulation of cytoplasmic translational fidelity

biological_process

Any process that modulates the ability of the cytoplasmic translational apparatus to interpret the genetic code.

[ "PMID:22768388" ]

null

[]

[ "GO:0006450", "GO:1900247" ]

[]

[ "GO:0006450", "GO:1900247" ]

[]

pg

2017-04-06T12:27:10Z

false

true

5

GO:0140019

140,019

histone H3K9cr reader activity

molecular_function

A histone reader that recognizes a histone H3 crotonylated at lysine 9.

[ "PMID:27105114" ]

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...

[ "H3K9cr modified histone binding" ]

[ "NARROW" ]

[]

[ "GO:0140006" ]

[]

[ "GO:0140006" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29384\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]

pg

2024-12-06T15:43:48Z

false

true

3

GO:0140020

140,020

DNA methyltransferase complex

cellular_component

A protein complex that possesses DNA methyltransferase activity.

[ "PMID:20939822", "PMID:24947342" ]

null

[]

[ "GO:0034708" ]

[]

[ "GO:0034708" ]

[]

pg

2017-04-06T19:12:09Z

false

true

9

GO:0140022

140,022

cnida

cellular_component

A giant secretory organelle that comprises a bulb-shape capsule containing a coiled hollow tubule structure attached to it. A cnida defines the phylum Cnidaria.

[ "Wikipedia:Cnida#Structure_and_function" ]

null

[ "cnidae (plural)" ]

[ "EXACT" ]

[]

[ "GO:0110165" ]

[]

[ "GO:0110165" ]

[]

cjm

2017-04-12T15:12:20Z

false

true

3

GO:0140023

140,023

tRNA adenosine deamination to inosine

biological_process

The removal of an amine group from an adenosine to produce inosine within a tRNA molecule.

[ "PMID:27974624" ]

null

[ "A-to-I tRNA editing" ]

[ "EXACT" ]

[]

[ "GO:0006400" ]

[]

[ "GO:0006400" ]

[]

pg

2017-04-26T05:56:51Z

false

true

4

GO:0140024

140,024

plus-end-directed endosome transport along mitotic spindle midzone microtubule

biological_process

The directed movement of an endosome towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an endosome to a microtubule, and ends when the endosome reaches its final destination.

[ "PMID:24803650", "PMID:25706234" ]

null

[]

[ "GO:0072383" ]

[]

[ "GO:0072383" ]

[]

pg

2017-04-29T11:34:23Z

false

true

4

GO:0140026

140,026

contractile vacuole dissociation from plasma membrane

biological_process

The dissociation of the contractile vacuole after discharge, from the plasma membrane. This interaction is mediated by detethering factors that initiate the process of tubulation and fragmentation of the empty contractile vacuole bladder, which is then reincorporated into the CV network.

[ "PMID:22323285" ]

null

[ "contractile vacuole detethering from plasma membrane" ]

[ "EXACT" ]

[]

[ "GO:0016192" ]

[]

[ "GO:0016192" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/13407\" xsd:anyURI" ]

pg

2017-05-02T10:16:12Z

false

true

7

GO:0140027

140,027

contractile vacuole localization

biological_process

The directed movement of the contractile vacuole to a specific location.

[ "PMID:19687255" ]

null

[ "establishment of contractile vacuole localization" ]

[ "NARROW" ]

[]

[ "GO:0051648", "GO:1990849" ]

[]

[ "GO:0051648", "GO:1990849" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/13407\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22182\" xsd:anyURI" ]

pg

2017-05-02T10:23:26Z

false

true

1

GO:0140028

140,028

pore formation during contractile vacuole discharge

biological_process

The formation of a transient pore in the plasma membrane and the attached contractile vacuolar membrane, to release water from the cell. This process does not involve fusion of the two membranes.

[ "PMID:22323285", "Wikipedia:Exocytosis" ]

null

[]

[ "GO:0140029" ]

[ "part_of GO:0070177" ]

[ "part_of" ]

[ "GO:0070177" ]

[ "GO:0070177", "GO:0140029" ]

[]

pg

2017-05-15T12:20:27Z

false

true

3

GO:0140029

140,029

exocytic process

biological_process

The cellular processes that contribute to exocytosis.

[ "Wikipedia:Exocytosis" ]

null

[]

[ "gocheck_do_not_annotate" ]

[]

[ "GO:0009987" ]

[ "part_of GO:0006887" ]

[ "part_of" ]

[ "GO:0006887" ]

[ "GO:0006887", "GO:0009987" ]

[ "GO:0009987", "part_of GO:0006887" ]

[]

pg

2017-05-15T13:20:45Z

false

true

5

GO:0140030

140,030

modification-dependent protein binding

molecular_function

Binding to a protein upon post-translation modification of the target protein.

[ "PMID:26060076" ]

This term should only be used when the binding is shown to require a post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the modification. It may be that the PTM causes a conformational change that allows binding of the protein to ...

[ "modified protein binding" ]

[ "RELATED" ]

[]

[ "GO:0005515" ]

[]

[ "GO:0005515" ]

[]

pg

2017-05-17T11:50:41Z

false

true

4

GO:0140031

140,031

phosphorylation-dependent protein binding

molecular_function

Binding to a protein upon phosphorylation of the target protein.

[ "PMID:26060076" ]

This term should only be used when the binding is shown to require phosphorylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of phosphorylation. It may be that the phosphorylation causes a conformational change that allows binding of ...

[]

[ "GO:0140030" ]

[]

[ "GO:0140030" ]

[]

pg

2017-05-17T15:15:19Z

false

true

6

GO:0140032

140,032

glycosylation-dependent protein binding

molecular_function

Binding to a protein upon glycosylation of the target protein.

[ "PMID:26060076" ]

This term should only be used when the binding is shown to require glycosylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of glycosylation. It may be that the glycosylation causes a conformational change that allows binding of the pr...

[]

[ "GO:0140030" ]

[]

[ "GO:0140030" ]

[]

pg

2017-05-17T15:20:50Z

false

true

2

GO:0140033

140,033

acetylation-dependent protein binding

molecular_function

Binding to a protein upon acetylation of the target protein.

[ "PMID:26060076" ]

This term should only be used when the binding is shown to require acetylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of acetylation. It may be that the acetylation causes a conformational change that allows binding of the protein ...

[]

[ "GO:0140030" ]

[]

[ "GO:0140030" ]

[]

pg

2017-05-17T15:35:43Z

false

true

7

GO:0140034

140,034

methylation-dependent protein binding

molecular_function

Binding to a protein upon methylation of the target protein.

[ "PMID:26060076" ]

This term should only be used when the binding is shown to require methylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of methylation. It may be that the methylation causes a conformational change that allows binding of the protein ...

[]

[ "GO:0140030" ]

[]

[ "GO:0140030" ]

[]

pg

2017-05-17T15:40:02Z

false

true

6

GO:0140035

140,035

ubiquitin-like protein reader activity

molecular_function

A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.

[ "PMID:26060076" ]

This term should only be used when the binding is shown to require a ubiquitin-like modification in the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitin-like modification. It may be that the modification causes a conformational change ...

[ "ubiquitination-like modification-dependent protein binding", "ubiquitination-like protein reader activity" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0030674" ]

[ "has_part GO:0140030" ]

[ "has_part" ]

[ "GO:0140030" ]

[ "GO:0030674", "GO:0140030" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27325\" xsd:anyURI" ]

pg

2017-05-18T06:11:27Z

false

true

2

GO:0140036

140,036

ubiquitin-modified protein reader activity

molecular_function

A molecular adaptor recognizes and binds a target protein containing a ubiquitination modification and brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.

[ "PMID:26060076" ]

This term should only be used when the binding is shown to require ubiquitination of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitination. It may be that the ubiquitination causes a conformational change that allows binding of the...

[ "ubiquitin-dependent protein binding" ]

[ "EXACT" ]

[]

[ "GO:0140035" ]

[]

[ "GO:0140035" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27325\" xsd:anyURI" ]

pg

2017-05-18T06:29:14Z

false

true

3

GO:0140037

140,037

SUMO-modified protein reader activity

molecular_function

A molecular adaptor that recognizes and binds a target protein containing a SUMO modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.

[ "PMID:26060076" ]

This term should only be used when the binding is shown to require sumoylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of sumoylation. It may be that the sumoylation causes a conformational change that allows binding of the protein ...

[ "SUMO-dependent protein binding" ]

[ "EXACT" ]

[]

[ "GO:0140035" ]

[]

[ "GO:0140035" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27325\" xsd:anyURI" ]

pg

2017-05-18T06:29:27Z

false

true

8

GO:0140038

140,038

histone H3K27cr reader activity

molecular_function

A histone reader that recognizes a histone H3 crotonylated at lysine 27.

[ "PMID:27105114" ]

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...

[ "histone H3K27cr modified histone binding" ]

[ "NARROW" ]

[]

[ "GO:0140006" ]

[]

[ "GO:0140006" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29384\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]

pg

2024-12-06T15:44:30Z

false

true

1

GO:0140039

140,039

cell-cell adhesion in response to extracellular stimulus

biological_process

The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus.

[ "PMID:14996911" ]

null

[]

[ "GO:0098609" ]

[ "part_of GO:0051716" ]

[ "part_of" ]

[ "GO:0051716" ]

[ "GO:0051716", "GO:0098609" ]

[ "GO:0098609", "part_of GO:0051716" ]

[]

pg

2017-05-24T11:37:30Z

false

true

7

GO:0140040

140,040

mitochondrial polycistronic RNA processing

biological_process

The conversion of polycistronic RNA transcribed from a mitochondrial genome into mono- or bi-cistronic RNAs.

[ "PMID:20211597" ]

null

[]

[ "GO:0000963" ]

[]

[ "GO:0000963" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29647\" xsd:anyURI" ]

pg

2017-06-16T07:18:38Z

false

true

8

GO:0140043

140,043

lipid droplet localization to prospore membrane leading edge

biological_process

Any process in which a lipid droplet is transported to, or maintained to the prospore membrane leading edge.

[ "PMID:28011631" ]

null

[ "adiposome localization to ascospore-type prospore membrane leading edge", "adiposome localization to forespore membrane leading edge", "adiposome localization to FSM membrane leading edge", "lipid body localization to ascospore-type prospore membrane leading edge", "lipid body localization to forespore mem...

[ "EXACT", "RELATED", "EXACT", "EXACT", "RELATED", "EXACT", "EXACT", "RELATED", "EXACT" ]

[]

[ "GO:0010876", "GO:0051668" ]

[]

[ "GO:0010876", "GO:0051668" ]

[]

pg

2017-06-19T09:20:13Z

false

true

8

GO:0140044

140,044

histone H3K18ac reader activity

molecular_function

A histone reader that recognizes a histone H3 acetylated at lysine 18.

[ "PMID:30110338" ]

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...

[ "histone H3K18ac modified histone binding" ]

[ "NARROW" ]

[]

[ "GO:0140006" ]

[]

[ "GO:0140006" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29384\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]

pg

2024-12-06T15:47:07Z

false

true

1

GO:0140046

140,046

histone H4K16ac reader activity

molecular_function

A histone reader that recognizes a histone H4 acetylated at lysine 16.

[ "PMID:16085498" ]

Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.

[ "H4K16ac modified histone binding" ]

[ "NARROW" ]

[]

[ "GO:0140008" ]

[]

[ "GO:0140008" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29384\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]

pg

2024-12-06T15:53:35Z

false

true

3

GO:0140047

140,047

specialized extracellular matrix

cellular_component

Species or cell-type specific extracellular matrices that are different from the two main types of extracellular matrices: the interstitial ECM and the basement membrane ECM in metazoa.

[ "PMID:28955324", "PMID:33605520" ]

null

[ "specialized ECM" ]

[ "EXACT" ]

[]

[ "GO:0031012" ]

[]

[ "GO:0031012" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29265\" xsd:anyURI" ]

pg

2024-12-13T08:19:31Z

false

true

2

GO:0140048

140,048

manganese ion export across plasma membrane

biological_process

The directed movement of manganese ions from inside of a cell, across the plasma membrane and into the extracellular region.

[ "PMID:25319704" ]

null

[ "manganese ion export from cell" ]

[ "EXACT" ]

[]

[ "GO:0071421", "GO:0140115" ]

[]

[ "GO:0071421", "GO:0140115" ]

[]

pg

2017-06-23T14:25:00Z

false

true

6

GO:0140049

140,049

regulation of endocardial cushion to mesenchymal transition

biological_process

Any process that modulates the frequency, rate or extent of endocardial cushion to mesenchymal transition.

[ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:21778427" ]

null

[]

[ "GO:0062042" ]

[ "regulates GO:0090500" ]

[ "regulates" ]

[ "GO:0090500" ]

[ "GO:0062042", "GO:0090500" ]

[ "GO:0065007", "regulates GO:0090500" ]

[]

pg

2017-06-23T15:57:00Z

false

true

9

GO:0140050

140,050

negative regulation of endocardial cushion to mesenchymal transition

biological_process

Any process that stops, prevents or reduces the frequency, rate or extent of endocardial cushion to mesenchymal transition.

[ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:21778427" ]

null

[]

[ "GO:0062044", "GO:0140049" ]

[ "negatively_regulates GO:0090500" ]

[ "negatively_regulates" ]

[ "GO:0090500" ]

[ "GO:0062044", "GO:0090500", "GO:0140049" ]

[ "GO:0065007", "negatively_regulates GO:0090500" ]

[]

pg

2017-06-26T09:02:27Z

false

true

8

GO:0140052

140,052

cellular response to oxidised low-density lipoprotein particle stimulus

biological_process

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus.

[ "GOC:aruk", "GOC:BHF", "PMID:20037584", "PMID:27607416" ]

null

[ "cellular response to ox-LDL particle stimulus", "cellular response to oxidised LDL particle stimulus", "cellular response to oxidized LDL particle stimulus", "cellular response to oxidized low-density lipoprotein particle stimulus", "cellular response to oxLDL particle stimulus" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0071404" ]

[]

[ "GO:0071404" ]

[]

pg

2017-06-26T09:40:00Z

false

true

6

GO:0140053

140,053

mitochondrial gene expression

biological_process

The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or cir...

[ "PMID:27058308" ]

null

[]

[ "goslim_generic", "goslim_pombe" ]

[]

[ "GO:0010467" ]

[ "occurs_in GO:0005739" ]

[ "occurs_in" ]

[ "GO:0005739" ]

[ "GO:0005739", "GO:0010467" ]

[ "GO:0010467", "occurs_in GO:0005739" ]

[]

pg

2017-06-26T10:57:45Z

false

true

7

GO:0140054

140,054

histone H2A reader activity

molecular_function

A histone reader that specifically binds either to an unmodified histone H2A or a form modified by a post-translational modification on a specific residue. The most common PTMs on histones are methylation, acetylation and phosphorylation.

[ "PMID:11498575", "PMID:25688442", "PMID:31082667", "PMID:34726351" ]

null

[ "histone H2A reader" ]

[ "EXACT" ]

[]

[ "GO:0140566" ]

[]

[ "GO:0140566" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29441\" xsd:anyURI" ]

pg

2024-12-13T14:14:39Z

false

true

7

GO:0140055

140,055

histone H4K8ac reader activity

molecular_function

A histone reader that recognizes a histone H4 acetylated at lysine 8.

[ "PMID:17996705" ]

Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.

[ "H4K8ac modified histone binding" ]

[ "NARROW" ]

[]

[ "GO:0140008" ]

[]

[ "GO:0140008" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29441\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]

pg

2024-12-13T14:54:04Z

false

true

4

GO:0140056

140,056

organelle localization by membrane tethering

biological_process

The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other.

[ "PMID:27875684" ]

null

[]

[ "goslim_pombe" ]

[]

[ "GO:0022406", "GO:0051640" ]

[]

[ "GO:0022406", "GO:0051640" ]

[]

pg

2017-06-27T09:58:51Z

false

true

9

GO:0140057

140,057

vacuole-mitochondria membrane tethering

biological_process

The attachment of a mitochondrial membrane to a vacuolar membrane via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.

[ "PMID:27875684" ]

null

[]

[ "GO:0140056" ]

[]

[ "GO:0140056" ]

[]

pg

2017-06-27T10:31:12Z

false

true

6

GO:0140058

140,058

neuron projection arborization

biological_process

The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites.

[ "GOC:aruk", "GOC:bc", "PMID:17114044", "PMID:23270857", "PMID:23764288" ]

null

[ "branching morphogenesis of a neurite", "branching morphogenesis of a neuron projection", "neurite arborization", "neurite branching", "neuron projection branching" ]

[ "RELATED", "RELATED", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0048812" ]

[]

[ "GO:0048812" ]

[]

pg

2017-07-12T12:25:31Z

false

true

3

GO:0140059

140,059

dendrite arborization

biological_process

The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches.

[ "GOC:aruk", "GOC:bc", "PMID:23270857" ]

null

[]

[ "GO:0048813", "GO:0140058" ]

[]

[ "GO:0048813", "GO:0140058" ]

[]

pg

2017-07-12T15:12:07Z

false

true

3

GO:0140060

140,060

axon arborization

biological_process

The process in which the terminal anatomical structures of an axon are generated and organized into branches of specialised projections, or boutons. An axon is the long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminal branches.

[ "GOC:aruk", "GOC:bc", "PMID:23764288" ]

null

[]

[ "GO:0007409", "GO:0140058" ]

[]

[ "GO:0007409", "GO:0140058" ]

[]

pg

2017-07-12T15:17:22Z

false

true

1

GO:0140061

140,061

obsolete 5-hydroxymethylcytosine dioxygenase activity

molecular_function

OBSOLETE. Catalysis of the reaction: 5-hydroxymethylcytosine + 2-oxoglutarate + O2 = 5-formylcytosine + succinate + CO2.

[ "PMID:27918559" ]

This term was obsoleted because it is a substep of the reaction represented by 5-methylcytosine dioxygenase activity ; GO:0070579.

[ "5hmC dioxygenase" ]

[ "EXACT" ]

[]

[ "GO:0070579" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/13950\" xsd:anyURI" ]

pg

2017-07-20T09:54:50Z

true

4

GO:0140062

140,062

obsolete 5-formylcytosine dioxygenase activity

molecular_function

OBSOLETE. Catalysis of the reaction: 5-formylcytosine+ 2-oxoglutarate + O2 = 5-carboxylcytosine + succinate + CO2.

[ "PMID:27918559" ]

This term was obsoleted because it is a substep of the reaction represented by 5-methylcytosine dioxygenase activity ; GO:0070579.

[ "5fC dioxygenase" ]

[ "EXACT" ]

[]

[ "GO:0070579" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/13950\" xsd:anyURI" ]

pg

2017-07-20T09:57:16Z

true

2

GO:0140063

140,063

unmodified histone reader activity

molecular_function

A histone reader that specifically binds either to an unmodified histone.

[ "GOC:pg" ]

Curator note: To annotate the specific histone recognized, use 'has input' extension.

[]

[ "GO:0140566" ]

[]

[ "GO:0140566" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29441\" xsd:anyURI" ]

pg

2024-12-13T14:55:58Z

false

true

2

GO:0140064

140,064

peptide crotonyltransferase activity

molecular_function

Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide.

[ "PMID:25818647" ]

null

[ "protein crotonyltransferase activity" ]

[ "RELATED" ]

[]

[ "RHEA:53908" ]

[ "GO:0016410" ]

[]

[ "GO:0016410" ]

[]

[ "skos:exactMatch RHEA:53908", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

pg

2017-07-20T16:40:57Z

false

true

9

GO:0140065

140,065

peptide butyryltransferase activity

molecular_function

Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide.

[ "PMID:27105113" ]

null

[ "protein butyryltransferase activity" ]

[ "RELATED" ]

[]

[ "RHEA:53912" ]

[ "GO:0016410" ]

[]

[ "GO:0016410" ]

[]

[ "skos:exactMatch RHEA:53912", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

pg

2017-07-20T16:46:49Z

false

true

9

GO:0140067

140,067

peptidyl-lysine butyrylation

biological_process

The butyrylation of a lysine residue in a protein. Butyryl is the univalent radical C3H7COO- derived from butyric acid.

[ "PMID:27105113", "Wikipedia:butyryl" ]

null

[]

[ "gocheck_obsoletion_candidate" ]

[]

[ "GO:0043543" ]

[]

[ "GO:0043543" ]

[]

pg

2017-07-20T16:52:19Z

false

true

7

GO:0140068

140,068

histone crotonyltransferase activity

molecular_function

Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone.

[ "PMID:25818647" ]

null

[]

[ "GO:0140064", "GO:0140993" ]

[]

[ "GO:0140064", "GO:0140993" ]

[]

[ "skos:broadMatch RHEA:53908", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]

pg

2017-07-20T16:55:16Z

false

true

7

GO:0140069

140,069

histone butyryltransferase activity

molecular_function

Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone.

[ "PMID:27105113" ]

null

[]

[ "GO:0140065", "GO:0140993" ]

[]

[ "GO:0140065", "GO:0140993" ]

[]

[ "skos:broadMatch RHEA:53912", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]

pg

2017-07-20T16:56:33Z

false

true

8

GO:0140070

140,070

hydrogen peroxide channel activity

molecular_function

Enables the energy-independent facilitated diffusion of H2O2 through a transmembrane aqueous pore or channel.

[ "PMID:23541115", "PMID:27256569" ]

null

[ "hydrogen peroxide transmembrane transporter activity" ]

[ "RELATED" ]

[]

[ "GO:0015267" ]

[ "part_of GO:0080170" ]

[ "part_of" ]

[ "GO:0080170" ]

[ "GO:0015267", "GO:0080170" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24070\" xsd:anyURI" ]

pg

2022-09-27T11:35:19Z

false

true

5

GO:0140071

140,071

histone H2B reader activity

molecular_function

A histone reader that specifically binds either to an unmodified histone H2B or a form modified by a post-translational modification on a specific residue. The most common PTMs on histones are methylation, acetylation and phosphorylation.

[ "PMID:11498575", "PMID:25688442", "PMID:31082667", "PMID:34726351" ]

null

[ "histone H2B reader" ]

[ "EXACT" ]

[]

[ "GO:0140566" ]

[]

[ "GO:0140566" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29441\" xsd:anyURI" ]

pg

2024-12-13T14:57:55Z

false

true

1

GO:0140072

140,072

histone H3K9ac reader activity

molecular_function

A histone reader that recognizes a histone H3 acetylated at lysine 9.

[ "PMID:26067602" ]

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...

[ "H3K9ac modified histone binding" ]

[ "NARROW" ]

[]

[ "GO:0140006" ]

[]

[ "GO:0140006" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29441\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]

pg

2024-12-13T14:59:50Z

false

true

9

GO:0140073

140,073

bioadhesive activity

molecular_function

A structural molecule ativity that mediates an organism's attachment to an environmental substrate via stable, non-selective binding by a protein to an external surface. Examples includes proteins used by insects to anchor pupae to surfaces.

[ "PMID:39370426" ]

null

[]

[ "GO:0005198" ]

[]

[ "GO:0005198" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29499\" xsd:anyURI" ]

pg

2025-01-23T07:41:17Z

false

true

9

GO:0140074

140,074

cardiac endothelial to mesenchymal transition

biological_process

A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cell...

[ "GOC:BHF", "GOC:nc", "PMID:16162442", "PMID:26053665" ]

null

[ "EndMT", "EndoMT" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0048762" ]

[]

[ "GO:0048762" ]

[]

pg

2017-07-21T09:39:49Z

false

true

1

GO:0140075

140,075

regulation of lipoprotein transport

biological_process

Any process that controls lipoprotein transport.

[ "GOC:BHF", "GOC:BHF_miRNA", "GOC:RPH", "PMID:26501192" ]

null

[]

[ "GO:0051223" ]

[ "regulates GO:0042953" ]

[ "regulates" ]

[ "GO:0042953" ]

[ "GO:0042953", "GO:0051223" ]

[ "GO:0065007", "regulates GO:0042953" ]

[]

pg

2017-07-21T15:35:47Z

false

true

1

GO:0140076

140,076

negative regulation of lipoprotein transport

biological_process

Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport.

[ "GOC:BHF", "GOC:BHF_miRNA", "GOC:RPH", "PMID:26501192" ]

null

[]

[ "GO:0051224", "GO:0140075" ]

[ "negatively_regulates GO:0042953" ]

[ "negatively_regulates" ]

[ "GO:0042953" ]

[ "GO:0042953", "GO:0051224", "GO:0140075" ]

[ "GO:0065007", "negatively_regulates GO:0042953" ]

[]

pg

2017-07-21T15:39:50Z

false

true

9

GO:0140077

140,077

positive regulation of lipoprotein transport

biological_process

Any process that activates or increases the rate or extent of lipoprotein transport.

[ "GOC:BHF", "GOC:BHF_miRNA", "GOC:RPH", "PMID:26501192" ]

null

[]

[ "GO:0051222", "GO:0140075" ]

[ "positively_regulates GO:0042953" ]

[ "positively_regulates" ]

[ "GO:0042953" ]

[ "GO:0042953", "GO:0051222", "GO:0140075" ]

[ "GO:0065007", "positively_regulates GO:0042953" ]

[]

pg

2017-07-21T15:41:54Z

false

true

2

GO:0140078

140,078

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

molecular_function

Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.

[ "PMID:1698278", "RHEA:66592" ]

null

[ "AP endonuclease class I activity", "AP lyase activity", "AP site-DNA 5'-phosphomonoester-lyase activity", "class I AP endonuclease activity", "class I DNA-(apurinic or apyrimidinic site) lyase activity", "DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity", "DNA-(apurinic or apyrimi...

[ "RELATED", "RELATED", "EXACT", "RELATED", "EXACT", "EXACT", "EXACT" ]

[]

[ "EC:4.2.99.18", "MetaCyc:4.2.99.18-RXN", "RHEA:66592", "Wikipedia:AP_endonuclease" ]

[ "GO:0003906", "GO:0016835" ]

[]

[ "GO:0003906", "GO:0016835" ]

[]

[ "skos:exactMatch EC:4.2.99.18", "skos:exactMatch RHEA:66592", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22262\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27071\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-onto...

pg

2017-07-24T11:33:34Z

false

true

4

GO:0140080

140,080

obsolete class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity

molecular_function

OBSOLETE. Catalysis of the cleavage of an AP site 3' and 5' of the baseless site, generating a 3'-phosphate and a 5'-OH.

[ "PMID:2519777" ]

Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.\nThe reason for obsoletion is that there is no longer credible...

[ "endonuclease III", "endonuclease IV" ]

[ "RELATED", "RELATED" ]

[]

[ "Wikipedia:AP_endonuclease" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22262\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27071\" xsd:anyURI" ]

pg

2017-07-24T11:48:18Z

true

6

GO:0140081

140,081

glycosylated region protein binding

molecular_function

Binding to a glycosylated region of a protein.

[ "GOC:pg" ]

null

[]

[ "GO:0005515", "GO:0097367" ]

[]

[ "GO:0005515", "GO:0097367" ]

[]

pg

2017-07-25T10:58:31Z

false

true

4

GO:0140082

140,082

SUMO-ubiquitin ligase activity

molecular_function

Isoenergetic transfer of SUMO from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine re...

[ "PMID:28552615" ]

null

[]

[ "GO:0061665" ]

[]

[ "GO:0061665" ]

[]

pg

2017-08-08T14:46:50Z

false

true

9

GO:0140083

140,083

ATP-dependent protein-DNA unloader activity

molecular_function

Facilitating the removal of a protein or protein complex from a DNA molecule driven by ATP hydrolysis. This can be achieved for example by introducing non-canonical DNA structures or generating torque to directly inhibit a protein-DNA binding interaction.

[ "PMID:28552615" ]

null

[ "ATP-dependent protein-DNA unloading activity", "protein-DNA unloading ATPase activity" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0008094" ]

[]

[ "GO:0008094" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/13992\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21612\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23400\" xsd:anyURI" ]

pg

2017-08-08T14:50:27Z

false

true

8

GO:0140084

140,084

sexual macrocyst formation

biological_process

The fusion of haploid amoebae cells with matching mating types to form a larger cell, which ingests additional amoebae and forms a cellulose wall. The resulting macrocyst undergoes recombination and meiosis followed by release of haploid amoebae. An example of this process can be found in Dictyostelium discoideum.

[ "PMID:16592095", "PMID:20089169" ]

null

[ "macrocyst formation", "sexual fusion" ]

[ "RELATED", "RELATED" ]

[]

[ "GO:0022413" ]

[]

[ "GO:0022413" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22929\" xsd:anyURI" ]

pg

2017-08-14T20:11:03Z

false

true

8

GO:0140085

140,085

L-amino-acid N-acetyltransferase activity

molecular_function

Catalysis of the reaction: acetyl-CoA + a L-amino acid = CoA + an N-acetyl-L-amino-acid. In some cases other acetyl containing molecules can be used as donor.

[ "GOC:pg", "RHEA:83863" ]

null

[]

[ "RHEA:83863" ]

[ "GO:0140379" ]

[]

[ "GO:0140379" ]

[]

[ "skos:narrowMatch RHEA:83863", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29604\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31474\" xsd:anyURI" ]

pg

2025-01-24T10:40:36Z

false

true

6

GO:0140087

140,087

acetaldehyde dehydrogenase (NAD+) activity

molecular_function

Catalysis of the reaction: acetaldehyde + NAD+ + H2O = acetate + NADH + 2 H+.

[ "PMID:9473035", "RHEA:25294" ]

null

[]

[ "RHEA:25294" ]

[ "GO:0004029" ]

[]

[ "GO:0004029" ]

[]

[ "skos:exactMatch RHEA:25294", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29544\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

pg

2025-01-28T07:26:40Z

false

true

1

GO:0140088

140,088

acetaldehyde dehydrogenase (NADP+) activity

molecular_function

Catalysis of the reaction: acetaldehyde + NADP+ + H2O = acetate + NADPH + 2 H+.

[ "PMID:15659684", "PMID:9473035", "RHEA:25298" ]

null

[]

[ "RHEA:25298" ]

[ "GO:0033721" ]

[]

[ "GO:0033721" ]

[]

[ "skos:exactMatch RHEA:25298", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29544\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

pg

2025-01-28T07:28:10Z

false

true

5

GO:0140090

140,090

membrane curvature sensor activity

molecular_function

Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins.

[ "PMID:25898166" ]

null

[]

[ "GO:0140299" ]

[ "has_part GO:0008289" ]

[ "has_part" ]

[ "GO:0008289" ]

[ "GO:0008289", "GO:0140299" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28772\" xsd:anyURI" ]

pg

2017-08-19T20:37:54Z

false

true

8

GO:0140091

140,091

mBAF complex

cellular_component

A muscle cell-specific SWI/SNF-type complex that contains eight to fourteen proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog o...

[ "GO:bhm", "PMID:11175787", "PMID:12620226", "PMID:15525990", "PMID:8804307", "PMID:8895581" ]

null

[ "muscle-specific BAF complex", "muscle-specific SWI/SNF complex", "muscle-type BAF complex", "muscle-type SWI/SNF complex" ]

[ "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0070603" ]

[]

[ "GO:0070603" ]

[]

pg

2017-09-05T09:20:45Z

false

true

4

GO:0140092

140,092

bBAF complex

cellular_component

A brain-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Dros...

[ "GOC:bhm", "PMID:12368262", "PMID:12620226", "PMID:15525990", "PMID:17640523", "PMID:17920018", "PMID:8804307", "PMID:8895581" ]

null

[ "brain-specific BAF complex", "brain-specific SWI/SNF complex" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0070603" ]

[]

[ "GO:0070603" ]

[]

pg

2017-09-05T09:22:41Z

false

true

3

GO:0140093

140,093

esBAF complex

cellular_component

An embryonic stem cell-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or an ortholog thereof. Compared to many other BAF c...

[ "GOC:bhm", "PMID:19279218", "PMID:19279220", "PMID:2620226", "PMID:8804307", "PMID:8895581" ]

null

[ "embryonic stem cell-specific BAF complex", "embryonic stem cell-specific SWI/SNF complex" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0070603" ]

[]

[ "GO:0070603" ]

[]

pg

2017-09-05T09:23:51Z

false

true

5

GO:0140095

140,095

cytoplasmic lattice

cellular_component

Fibrous structures of the mammalian ooplasm that store ribosomes and maternal proteins in insoluble form to prevent their degradation, activation and nuclear transfer.

[ "PMID:37922900", "PMID:38955588" ]

null

[]

[ "GO:0043232" ]

[ "part_of GO:1990917" ]

[ "part_of" ]

[ "GO:1990917" ]

[ "GO:0043232", "GO:1990917" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29620\" xsd:anyURI" ]

pg

2025-01-30T10:24:24Z

false

true

4

GO:0140096

140,096

catalytic activity, acting on a protein

molecular_function

Catalytic activity that acts to modify a protein.

[ "GOC:molecular_function_refactoring", "GOC:pdt" ]

null

[]

[ "goslim_generic", "goslim_prokaryote" ]

[]

[ "GO:0003824" ]

[]

[ "GO:0003824" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14225\" xsd:anyURI" ]

pg

2017-09-14T10:32:59Z

false

true

9

GO:0140098

140,098

catalytic activity, acting on RNA

molecular_function

Catalytic activity that acts to modify RNA.

[ "GOC:molecular_function_refactoring", "GOC:pdt" ]

null

[]

[ "goslim_generic", "goslim_prokaryote" ]

[]

[ "GO:0140640" ]

[]

[ "GO:0140640" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14208\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14225\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21612\" xsd:anyURI" ]

pg

2017-09-14T12:05:21Z

false

true

6

GO:0140099

140,099

venom-mediated suppression of fibrinolysis

biological_process

A process in which an organism inhibits or disrupts fibrinolysis in another organism via the action of a venom. Fibrinolysis is the solubilization of fibrin in the bloodstream. Anti-fibrinolytic proteins reduce bleeding at the bite or sting site of the prey.

[ "PMID:19236611", "PMID:22359676", "PMID:27208884", "PMID:35716829" ]

null

[ "envenomation suppressing fibrinolysis in another organism" ]

[ "EXACT" ]

[]

[ "GO:0044483" ]

[]

[ "GO:0044483" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29652\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29851\" xsd:anyURI" ]

pg

2025-02-04T15:52:00Z

false

true

5

GO:0140101

140,101

catalytic activity, acting on a tRNA

molecular_function

Catalytic activity that acts to modify a tRNA.

[ "GOC:molecular_function_refactoring", "GOC:pdt" ]

Note that this term excludes activities for which a charged tRNA acts as an amino acid donor.

[]

[ "GO:0140098" ]

[]

[ "GO:0140098" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14225\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25516\" xsd:anyURI" ]

pg

2017-09-15T18:41:41Z

false

true

4

GO:0140102

140,102

catalytic activity, acting on a rRNA

molecular_function

Catalytic activity that acts to modify a ribosomal RNA.

[ "GOC:molecular_function_refactoring", "GOC:pdt" ]

null

[]

[ "GO:0140098" ]

[]

[ "GO:0140098" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14225\" xsd:anyURI" ]

pg

2017-09-15T19:00:57Z

false

true

3

GO:0140103

140,103

catalytic activity, acting on a glycoprotein

molecular_function

Catalysis of a biochemical reaction in which one of the substrates is a glycoprotein.

[ "GOC:molecular_function_refactoring", "GOC:pdt" ]

null

[]

[ "GO:0140096" ]

[]

[ "GO:0140096" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14225\" xsd:anyURI" ]

pg

2017-09-15T19:27:54Z

false

true

7