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GO

Dataset card Data Studio Files
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 Community
go_id
string
go_numeric_id
int64
name
string
namespace
string
definition
string
definition_xrefs
list
comment
string
synonyms
list
synonym_scopes
list
alt_ids
list
subsets
list
xrefs
list
is_a_ids
list
relationship_edges
list
relationship_types
list
relationship_target_ids
list
parent_ids
list
intersection_of
list
union_of
list
disjoint_from
list
replaced_by
list
consider
list
property_values
list
created_by
string
creation_date
string
is_obsolete
bool
in_go_basic
bool
split_bucket
int64
GO:0140104
140,104
molecular carrier activity
molecular_function
Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location.
[ "GOC:molecular_function_refactoring", "GOC:pdt" ]
Note that a carrier moves with its substrate/cargo, while a transporter does not move with the cargo, but facilitates the change in localization.
[]
[]
[]
[ "goslim_euk_cellular_processes_ribbon", "goslim_generic", "goslim_plant_ribbon", "goslim_prokaryote", "goslim_prokaryote_ribbon" ]
[ "Reactome:R-HSA-1449687 \"Corticosteroids bind to CBG in blood\"", "Reactome:R-HSA-196126 \"STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space\"", "Reactome:R-HSA-209738 \"VD3 binds GC\"", "Reactome:R-HSA-209944 \"25(OH)D binds GC\"", "Reactome:R-HSA-2395764 \"atREs binds to ...
[ "GO:0003674" ]
[ "has_part GO:0005488" ]
[ "has_part" ]
[ "GO:0005488" ]
[ "GO:0003674", "GO:0005488" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14221\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20848\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29584\" xsd:anyURI" ]
pg
2017-09-19T13:10:18Z
false
true
5
GO:0140105
140,105
interleukin-10-mediated signaling pathway
biological_process
The series of molecular signals initiated by interleukin-10 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
[ "PMID:11244051" ]
null
[ "IL-10-mediated signaling pathway", "interleukin-10-mediated signalling pathway" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0019221" ]
[]
[]
[]
[ "GO:0019221" ]
[]
[]
[]
[]
[]
[]
pg
2017-09-22T16:04:42Z
false
true
1
GO:0140106
140,106
hematophagy
biological_process
A feeding behavior that involves the ingestion of blood. Hematophagous animals have mouth parts and chemical agents for penetrating vascular structures in the skin of hosts. To overcome natural hemostasis, vasoconstriction, inflammation, and pain sensation in the host, hematophagous animals pre-inject chemical substanc...
[ "Wikipedia:Hematophagy" ]
null
[ "feeding on blood of other organism", "injection of substance into other organism during feeding on blood of other organism", "taking of blood meal" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[ "Wikipedia:Hematophagy" ]
[ "GO:0007631", "GO:0044419" ]
[]
[]
[]
[ "GO:0007631", "GO:0044419" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29699\" xsd:anyURI" ]
pg
2025-02-11T13:58:07Z
false
true
6
GO:0140107
140,107
high-affinity potassium ion transmembrane transporter activity
molecular_function
Enables the transfer of potassium ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
[ "PMID:10629185" ]
null
[]
[]
[]
[]
[]
[ "GO:0015079" ]
[]
[]
[]
[ "GO:0015079" ]
[]
[]
[]
[]
[]
[]
pg
2017-10-12T09:54:39Z
false
true
5
GO:0140108
140,108
high-affinity D-glucose transmembrane transporter activity
molecular_function
Enables the transfer of D-glucose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
[ "PMID:25411338" ]
null
[ "high-affinity glucose transmembrane transporter activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0055056" ]
[]
[]
[]
[ "GO:0055056" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14212\" xsd:anyURI" ]
pg
2017-10-12T10:06:19Z
false
true
9
GO:0140109
140,109
histone H3K4me1 reader activity
molecular_function
A histone reader that recognizes a histone H3 monomethylated at lysine 4.
[ "PMID:18840606", "PMID:29255264" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "H3-K4me1 modified histone binding", "H3K4me1 modified histone binding" ]
[ "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0140006" ]
[]
[]
[]
[ "GO:0140006" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29730\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]
pg
2025-02-14T14:05:29Z
false
true
5
GO:0140110
140,110
transcription regulator activity
molecular_function
A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the o...
[ "GOC:pg", "GOC:txnOH-2018", "Wikipedia:Transcription_factor" ]
null
[]
[]
[]
[ "gocheck_do_not_annotate", "goslim_euk_cellular_processes_ribbon", "goslim_flybase_ribbon", "goslim_generic", "goslim_plant", "goslim_plant_ribbon", "goslim_prokaryote", "goslim_prokaryote_ribbon" ]
[]
[ "GO:0003674" ]
[]
[]
[]
[ "GO:0003674" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/13588\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23609\" xsd:anyURI" ]
pg
2017-10-18T07:05:44Z
false
true
9
GO:0140111
140,111
[choline trimethylamine-lyase]-activating enzyme activity
molecular_function
Catalyzes the activation of choline trimethylamine-lyase by generation of an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM).
[ "PMID:24854437" ]
null
[]
[]
[]
[]
[ "MetaCyc:RXN-16470" ]
[ "GO:0043364" ]
[]
[]
[]
[ "GO:0043364" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14190\" xsd:anyURI" ]
pg
2017-10-20T13:57:38Z
false
true
5
GO:0140112
140,112
extracellular vesicle biogenesis
biological_process
The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based ...
[ "PMID:28736435" ]
null
[ "extracellular vesicle assembly" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0044085" ]
[]
[]
[]
[ "GO:0044085" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14256\" xsd:anyURI" ]
pg
2017-10-23T11:53:42Z
false
true
9
GO:0140113
140,113
extracellular microvesicle biogenesis
biological_process
The assembly and secretion of a set of components to form an extracellular microvesicule, a membrane-bounded vesicle that ranges in size 100 nm to 1 micron in size) and exits the cell by budding.
[ "PMID:28736435" ]
null
[ "extracellular microvesicle assembly" ]
[ "RELATED" ]
[]
[]
[]
[ "GO:0140112" ]
[]
[]
[]
[ "GO:0140112" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14256\" xsd:anyURI" ]
pg
2017-10-23T12:00:11Z
false
true
6
GO:0140114
140,114
cellular detoxification of fluoride
biological_process
Any process carried out at the cellular level that reduces or removes the toxicity of a fluoride. These may include chemical modification or transport of fluoride away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
[ "GOC:vw" ]
null
[]
[]
[]
[]
[]
[ "GO:0061687", "GO:1990748" ]
[ "part_of GO:1902618" ]
[ "part_of" ]
[ "GO:1902618" ]
[ "GO:0061687", "GO:1902618", "GO:1990748" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14391\" xsd:anyURI" ]
pg
2017-10-23T15:39:43Z
false
true
9
GO:0140115
140,115
export across plasma membrane
biological_process
The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region.
[ "GOC:pg" ]
null
[ "efflux" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0055085", "GO:0140352" ]
[]
[]
[]
[ "GO:0055085", "GO:0140352" ]
[]
[]
[]
[]
[]
[]
pg
2017-10-24T14:38:16Z
false
true
5
GO:0140116
140,116
fluoride export across plasma membrane
biological_process
The directed movement of fluoride ions from inside of a cell, across the plasma membrane and into the extracellular region.
[ "GOC:vw", "PMID:27327046" ]
null
[]
[]
[]
[]
[]
[ "GO:0140115", "GO:1903424" ]
[]
[]
[]
[ "GO:0140115", "GO:1903424" ]
[]
[]
[]
[]
[]
[]
pg
2017-10-24T14:51:01Z
false
true
1
GO:0140117
140,117
histone H4K20me1 reader activity
molecular_function
A histone reader that recognizes a histone H4 monomethylated at lysine 20.
[ "PMID:19494831" ]
Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
[ "H4K20me1 modified histone binding" ]
[ "NARROW" ]
[]
[]
[]
[ "GO:0140008" ]
[]
[]
[]
[ "GO:0140008" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29730\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]
pg
2025-02-14T14:09:09Z
false
true
8
GO:0140118
140,118
histone H3K23ac reader activity
molecular_function
A histone reader that recognizes a histone H3 acetylated at lysine 23.
[ "PMID:21164480" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3K23ac modified histone binding" ]
[ "RELATED" ]
[]
[]
[]
[ "GO:0140006" ]
[]
[]
[]
[ "GO:0140006" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29778\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]
pg
2025-02-21T15:27:16Z
false
true
6
GO:0140119
140,119
histone H3K27ac reader activity
molecular_function
A histone reader that recognizes a histone H3 acetylated at lysine 27.
[ "PMID:25417107" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3K27ac modified histone binding" ]
[ "NARROW" ]
[]
[]
[]
[ "GO:0140006" ]
[]
[]
[]
[ "GO:0140006" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29384\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]
pg
2025-02-14T14:27:16Z
false
true
2
GO:0140120
140,120
histone H2AK15ub reader activity
molecular_function
A histone reader that recognizes a histone H2A ubiquitinated at lysine 15.
[ "PMID:23760478" ]
Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across dif...
[]
[]
[]
[]
[]
[ "GO:0140054" ]
[]
[]
[]
[ "GO:0140054" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29778\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]
pg
2025-02-21T14:58:43Z
false
true
6
GO:0140121
140,121
Lewy body formation
biological_process
The aggregation, arrangement and bonding together of a set of components to form a Lewy body.
[ "PMID:15158159" ]
null
[]
[]
[]
[]
[]
[ "GO:0070841" ]
[]
[]
[]
[ "GO:0070841" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14160\" xsd:anyURI" ]
pg
2017-10-25T06:59:12Z
false
true
8
GO:0140122
140,122
regulation of Lewy body formation
biological_process
Any process that modulates the frequency, rate or extent of Lewy body formation.
[ "GOC:sl" ]
null
[]
[]
[]
[]
[]
[ "GO:0090083" ]
[ "regulates GO:0140121" ]
[ "regulates" ]
[ "GO:0140121" ]
[ "GO:0090083", "GO:0140121" ]
[ "GO:0065007", "regulates GO:0140121" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14160\" xsd:anyURI" ]
pg
2017-10-25T07:03:29Z
false
true
4
GO:0140123
140,123
negative regulation of Lewy body formation
biological_process
Any process that stops, prevents or reduces the frequency, rate or extent of Lewy body formation.
[ "GOC:sl" ]
null
[]
[]
[]
[]
[]
[ "GO:0090084", "GO:0140122" ]
[ "negatively_regulates GO:0140121" ]
[ "negatively_regulates" ]
[ "GO:0140121" ]
[ "GO:0090084", "GO:0140121", "GO:0140122" ]
[ "GO:0065007", "negatively_regulates GO:0140121" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14160\" xsd:anyURI" ]
pg
2017-10-25T07:08:56Z
false
true
3
GO:0140124
140,124
positive regulation of Lewy body formation
biological_process
Any process that activates or increases the frequency, rate or extent of Lewy body formation.
[ "GOC:sl" ]
null
[]
[]
[]
[]
[]
[ "GO:0090261", "GO:0140122" ]
[ "positively_regulates GO:0140121" ]
[ "positively_regulates" ]
[ "GO:0140121" ]
[ "GO:0090261", "GO:0140121", "GO:0140122" ]
[ "GO:0065007", "positively_regulates GO:0140121" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14160\" xsd:anyURI" ]
pg
2017-10-25T07:10:14Z
false
true
1
GO:0140125
140,125
thiamine import across plasma membrane
biological_process
The directed movement of thiamine from outside of a cell, across the plasma membrane and into the cytosol.
[ "GOC:vw" ]
null
[]
[]
[]
[]
[]
[ "GO:0071934", "GO:0098739" ]
[]
[]
[]
[ "GO:0071934", "GO:0098739" ]
[]
[]
[]
[]
[]
[]
pg
2017-10-25T11:09:23Z
false
true
2
GO:0140126
140,126
histone H2AK15ac reader activity
molecular_function
A histone reader that recognizes a histone H2A acetylated at lysine 15.
[ "PMID:27153538" ]
Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across dif...
[]
[]
[]
[]
[]
[ "GO:0140054" ]
[]
[]
[]
[ "GO:0140054" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29778\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]
pg
2025-02-21T14:58:43Z
false
true
8
GO:0140127
140,127
histone H3R8me2 reader activity
molecular_function
A histone reader that recognizes a histone H3 dimethylate at arginine 8. The methylation can be symmetrical or asymmetrical.
[ "PMID:24589551" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[]
[]
[]
[]
[]
[ "GO:0140006" ]
[]
[]
[]
[ "GO:0140006" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29778\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]
pg
2025-02-21T15:22:27Z
false
true
1
GO:0140128
140,128
histone H1 reader activity
molecular_function
A histone reader that specifically binds either to an unmodified histone H1 or a form modified by a post-translational modification on a specific residue. The most common PTMs on histones are methylation, acetylation and phosphorylation.
[ "PMID:17540172" ]
null
[]
[]
[]
[]
[]
[ "GO:0140566" ]
[]
[]
[]
[ "GO:0140566" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29778\" xsd:anyURI" ]
pg
2025-02-21T15:25:48Z
false
true
2
GO:0140129
140,129
histone H3K56ac reader activity
molecular_function
A histone reader that recognizes a histone H3 acetylated at lysine 56.
[ "PMID:23798425" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[]
[]
[]
[]
[]
[ "GO:0140006" ]
[]
[]
[]
[ "GO:0140006" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29778\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]
pg
2025-02-21T15:42:24Z
false
true
8
GO:0140130
140,130
histone H2AK5ac reader activity
molecular_function
A histone reader that recognizes a histone H2A acetylated at lysine 5.
[ "PMID:18469222" ]
Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is conserved across all eukaryotes. Corresponds to H2AK4 in yeast and in flies. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multi...
[]
[]
[]
[]
[]
[ "GO:0140054" ]
[]
[]
[]
[ "GO:0140054" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29778\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]
pg
2025-02-24T07:30:35Z
false
true
8
GO:0140131
140,131
positive regulation of lymphocyte chemotaxis
biological_process
Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis.
[ "PMID:19255442" ]
null
[]
[]
[]
[]
[]
[ "GO:0002690", "GO:1901623", "GO:2000403" ]
[ "positively_regulates GO:0048247" ]
[ "positively_regulates" ]
[ "GO:0048247" ]
[ "GO:0002690", "GO:0048247", "GO:1901623", "GO:2000403" ]
[ "GO:0065007", "positively_regulates GO:0048247" ]
[]
[]
[]
[]
[]
pg
2017-11-02T10:26:40Z
false
true
1
GO:0140133
140,133
obsolete symbiont-mediated suppression of host cytokine production
biological_process
OBSOLETE. A process by which a symbiont inhibits or disrupts cytokine production in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:23083102" ]
This term was obsoleted because it represents a readout.
[ "negative regulation by symbiont of host cytokine production", "suppression by symbiont of host cytokine production", "suppression by symbiont of host cytokine secretion" ]
[ "EXACT", "EXACT", "RELATED" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0052027" ]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14553\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29259\" xsd:anyURI" ]
pg
2017-11-14T07:07:04Z
true
true
5
GO:0140134
140,134
venom-mediated perturbation of blood circulation
biological_process
A process in which an organism alters or subverts the circulation of blood in another organism via the action of a venom.
[ "PMID:31370142" ]
null
[ "venom-mediated perturbation of cardiovascular system", "venom-mediated perturbation of circulatory system process" ]
[ "BROAD", "BROAD" ]
[]
[]
[]
[ "GO:0035738" ]
[]
[]
[]
[ "GO:0035738" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29794\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30014\" xsd:anyURI" ]
pg
2025-02-25T09:17:46Z
false
true
7
GO:0140135
140,135
mechanosensitive monoatomic cation channel activity
molecular_function
Enables the transmembrane transfer of a monoatomic cation by a channel that opens in response to a mechanical stress.
[ "GOC:ha", "PMID:22343900" ]
null
[ "mechanically-gated cation channel activity", "mechanosensitive cation channel activity" ]
[ "EXACT", "BROAD" ]
[]
[]
[ "Reactome:R-HSA-9659380 \"Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell\"", "Reactome:R-HSA-9663363 \"Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer...
[ "GO:0005261", "GO:0008381" ]
[]
[]
[]
[ "GO:0005261", "GO:0008381" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14588\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24479\" xsd:anyURI" ]
pg
2017-11-17T12:40:37Z
false
true
8
GO:0140137
140,137
venom-mediated perturbation of muscle system process
biological_process
A process in which an organism alters or subverts a muscular process in another organism via the action of a venom.
[ "GOC:pg" ]
null
[]
[]
[]
[]
[]
[ "GO:0035738" ]
[]
[]
[]
[ "GO:0035738" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29794\" xsd:anyURI" ]
pg
2025-02-25T09:18:30Z
false
true
5
GO:0140138
140,138
venom-mediated disruption of anatomical structure in another organism
biological_process
A process by which an organism effects a change that impairs the structure or function of an anatomical structure in another organism via the action of a venom. Venoms are injected into the prey by a bite or a sting.
[ "GOC:pg" ]
null
[]
[]
[]
[]
[]
[ "GO:0141060" ]
[]
[]
[]
[ "GO:0141060" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29794\" xsd:anyURI" ]
pg
2025-02-25T09:31:25Z
false
true
9
GO:0140139
140,139
solid phase of basement membrane
cellular_component
The solid compartment of the basement membrane ECM, including a specific subset of basement membrane collagens and basement membrane glycoproteins like laminins or nidogens.
[ "PMID:33972551" ]
null
[]
[]
[]
[]
[]
[ "GO:0030312" ]
[ "part_of GO:0005604" ]
[ "part_of" ]
[ "GO:0005604" ]
[ "GO:0005604", "GO:0030312" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29504\" xsd:anyURI" ]
pg
2025-03-20T11:44:22Z
false
true
7
GO:0140140
140,140
mitochondrial guanine nucleotide transmembrane transport
biological_process
The process in which a guanine nucleotide is transported across a mitochondrial membrane, into or out of the mitochondrion.
[ "GOC:vw", "PMID:14998997" ]
null
[]
[]
[]
[]
[]
[ "GO:1903716" ]
[]
[]
[]
[ "GO:1903716" ]
[]
[]
[]
[]
[]
[]
pg
2017-11-24T13:26:17Z
false
true
5
GO:0140141
140,141
mitochondrial potassium ion transmembrane transport
biological_process
The process in which a potassium ion is transported across a mitochondrial membrane, into or out of the mitochondrion.
[ "GOC:vw", "PMID:20197279" ]
null
[]
[]
[]
[]
[]
[ "GO:0071805" ]
[]
[]
[]
[ "GO:0071805" ]
[]
[]
[]
[]
[]
[]
pg
2017-11-24T13:26:42Z
false
true
7
GO:0140142
140,142
nucleocytoplasmic carrier activity
molecular_function
Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein.
[ "GOC:pg" ]
null
[ "miRNA transporter activity", "nucleocytoplasmic importin/exportin activity", "pre-miRNA transporter activity" ]
[ "NARROW", "EXACT", "NARROW" ]
[ "GO:0061717", "GO:0090631" ]
[ "gocheck_do_not_annotate" ]
[]
[ "GO:0140104" ]
[ "part_of GO:0006913" ]
[ "part_of" ]
[ "GO:0006913" ]
[ "GO:0006913", "GO:0140104" ]
[ "GO:0140104", "part_of GO:0006913" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14336\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17399\" xsd:anyURI" ]
pg
2017-12-06T13:40:40Z
false
true
4
GO:0140143
140,143
collagenous component of basement membrane
cellular_component
Collagenous component of basement membrane ECMs, including collagen IV and other types of collagen specifically expressed in basement membrane.
[ "PMID:21123617", "PMID:21421915", "PMID:28040522", "PMID:28324731", "PMID:31387942", "PMID:39223427" ]
null
[]
[]
[]
[]
[]
[ "GO:0030312" ]
[ "part_of GO:0140139" ]
[ "part_of" ]
[ "GO:0140139" ]
[ "GO:0030312", "GO:0140139" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29472\" xsd:anyURI" ]
pg
2025-03-20T11:47:59Z
false
true
3
GO:0140144
140,144
non-collagenous component of basement membrane
cellular_component
The non-collagenous compartment of the solid phase in basement membrane ECM, including glycoproteins like laminins or nidogens.
[ "PMID:21421915", "PMID:28324731" ]
null
[]
[]
[]
[]
[]
[ "GO:0030312" ]
[ "part_of GO:0140139" ]
[ "part_of" ]
[ "GO:0140139" ]
[ "GO:0030312", "GO:0140139" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29491\" xsd:anyURI" ]
pg
2025-03-20T11:59:22Z
false
true
1
GO:0140145
140,145
copper ion export from vacuole
biological_process
The directed movement of copper ions out of the vacuole across the vacuolar membrane.
[ "GOC:vw", "PMID:12244050" ]
null
[]
[]
[]
[]
[]
[ "GO:0010496", "GO:0034486", "GO:0035434" ]
[]
[]
[]
[ "GO:0010496", "GO:0034486", "GO:0035434" ]
[]
[]
[]
[]
[]
[]
pg
2017-12-13T15:02:39Z
false
true
6
GO:0140146
140,146
calcium ion import into vacuole
biological_process
The directed movement of calcium cations into the vacuole across the vacuolar membrane.
[ "GOC:vw", "PMID:8628289" ]
null
[]
[]
[]
[]
[]
[ "GO:0010496", "GO:0034486", "GO:0070588" ]
[]
[]
[]
[ "GO:0010496", "GO:0034486", "GO:0070588" ]
[]
[]
[]
[]
[]
[]
pg
2017-12-13T15:15:29Z
false
true
8
GO:0140147
140,147
zinc ion export from vacuole
biological_process
The directed movement of zinc ions from inside the vacuole across the vacuolar membrane and into the cytosol.
[ "GOC:vw", "PMC:PMC203372" ]
null
[]
[]
[]
[]
[]
[ "GO:0010496", "GO:0034486", "GO:0071577" ]
[]
[]
[]
[ "GO:0010496", "GO:0034486", "GO:0071577" ]
[]
[]
[]
[]
[]
[]
pg
2017-12-13T15:21:10Z
false
true
6
GO:0140149
140,149
non-collagenous component of interstitial matrix
cellular_component
The non-collagenous component of interstitial extracellular matrices, including glycoprotein like fibronectin and elastin.
[ "PMID:21123617", "PMID:25701227", "PMID:33605520", "PMID:39223427" ]
null
[]
[]
[]
[]
[]
[ "GO:0030312" ]
[ "part_of GO:0140151" ]
[ "part_of" ]
[ "GO:0140151" ]
[ "GO:0030312", "GO:0140151" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29491\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30146\" xsd:anyURI" ]
pg
2025-03-20T13:08:49Z
false
true
8
GO:0140150
140,150
gel phase of interstitial matrix
cellular_component
Hydrogel filling the interstitial extracellular matrix space. Composed of proteoglycans such as hyaluronan and lectin-binding proteoglycans, SPOCK proteoglycans and small leucin-rich proteoglycan (SLRP).
[ "PMID:21123617", "PMID:25701227", "PMID:33605520", "PMID:39223427" ]
null
[]
[]
[]
[]
[]
[ "GO:0030312" ]
[ "part_of GO:0005614" ]
[ "part_of" ]
[ "GO:0005614" ]
[ "GO:0005614", "GO:0030312" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29269\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29488\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29489\" xsd:anyURI", "term_tracker_item \"https://gi...
pg
2025-03-20T13:00:54Z
false
true
4
GO:0140151
140,151
solid phase of interstitial matrix
cellular_component
The solid compartment of the interstitial matrix, including interstitial collagens such as fibrillar and fibril-associated collagens and non-collagenous glycoproteins like fibronectin and elastin.
[ "PMID:3284468", "PMID:34807416" ]
null
[]
[]
[]
[]
[]
[ "GO:0030312" ]
[ "part_of GO:0005614" ]
[ "part_of" ]
[ "GO:0005614" ]
[ "GO:0005614", "GO:0030312" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29505\" xsd:anyURI" ]
pg
2025-03-20T11:44:22Z
false
true
4
GO:0140152
140,152
collagenous component of interstitial matrix
cellular_component
Main components of the interstitial matrix solid phase, including fibrillar and fibril-associated collagens.
[ "PMID:12064927", "PMID:17550969", "PMID:21421911", "PMID:28101870", "PMID:39223427" ]
null
[]
[]
[]
[]
[]
[ "GO:0030312" ]
[ "part_of GO:0140151" ]
[ "part_of" ]
[ "GO:0140151" ]
[ "GO:0030312", "GO:0140151" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29473\" xsd:anyURI" ]
pg
2025-03-20T11:47:59Z
false
true
3
GO:0140153
140,153
FACIT collagen complex
cellular_component
A supramolecular complex formed by fibril-associated collagens with interrupted triple helices (FACIT) that associate with collagen fibrils and forms a link on large, banded fibrils.
[ "PMID:1882421", "PMID:21421911" ]
null
[]
[]
[]
[]
[]
[ "GO:0098644" ]
[ "part_of GO:0140152" ]
[ "part_of" ]
[ "GO:0140152" ]
[ "GO:0098644", "GO:0140152" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29466\" xsd:anyURI" ]
pg
2025-03-26T06:33:06Z
false
true
5
GO:0140154
140,154
chicken-wire-like collagen network
cellular_component
Network-forming collagens can either form a chicken-wire-like network or a hexagonal network. Collagen type IV forms a chicken-wire-like structure and is found in the basement membrane.
[ "PMID:21421911", "PMID:21421915", "PMID:31387942" ]
null
[]
[]
[]
[]
[]
[ "GO:0098645" ]
[ "part_of GO:0140143" ]
[ "part_of" ]
[ "GO:0140143" ]
[ "GO:0098645", "GO:0140143" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29401\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30149\" xsd:anyURI" ]
pg
2025-03-26T06:42:53Z
false
true
9
GO:0140155
140,155
obsolete hexagonal collagen network of basement membrane
cellular_component
OBSOLETE. Supramolecular structure formed by trimers of collagen VIII and found in the basement membrane.
[ "PMID:21421911", "PMID:2376131", "PMID:3047147", "PMID:31387942" ]
This term was obsoleted because it is an uncessary grouping term. There is not sufficient evidence to show that collagen VIII is only located in the basement membrane in all organs and species.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0098646" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29402\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31492\" xsd:anyURI" ]
pg
2025-03-26T06:55:36Z
true
true
1
GO:0140156
140,156
multiplexin collagen trimer
cellular_component
Collagen that contains multiple triple-helix domains with interruptions.
[ "PMID:21421911", "PMID:27746220", "PMID:31479735", "PMID:33543021" ]
null
[]
[]
[]
[]
[]
[ "GO:0005581", "GO:0140392" ]
[ "part_of GO:0140143" ]
[ "part_of" ]
[ "GO:0140143" ]
[ "GO:0005581", "GO:0140143", "GO:0140392" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29469\" xsd:anyURI" ]
pg
2025-03-26T07:08:30Z
false
true
6
GO:0140157
140,157
ammonium import across plasma membrane
biological_process
The directed movement of an ammonium ion from outside of a cell, across the plasma membrane and into the cytosol.
[ "GOC:vw", "PMID:16999738" ]
null
[]
[]
[]
[]
[]
[ "GO:0072488", "GO:0098659" ]
[]
[]
[]
[ "GO:0072488", "GO:0098659" ]
[]
[]
[]
[]
[]
[]
pg
2018-01-26T12:39:56Z
false
true
6
GO:0140158
140,158
von-Willerbrand-factor-A-domain-rich collagen trimer
cellular_component
A family of collagens containing multiple von Willebrand factor A (vWA) domains.
[ "PMID:21421911" ]
null
[]
[]
[]
[]
[]
[ "GO:0005581" ]
[]
[]
[]
[ "GO:0005581" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29476\" xsd:anyURI" ]
pg
2025-03-26T07:29:07Z
false
true
2
GO:0140159
140,159
borate export across plasma membrane
biological_process
The directed movement of borate from inside of a cell, across the plasma membrane and into the extracellular region.
[ "GOC:vw", "PMID:17459946" ]
null
[]
[]
[]
[]
[]
[ "GO:0035445", "GO:0140115" ]
[]
[]
[]
[ "GO:0035445", "GO:0140115" ]
[]
[]
[]
[]
[]
[]
pg
2018-02-02T10:21:37Z
false
true
9
GO:0140161
140,161
monocarboxylate:sodium symporter activity
molecular_function
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monocarboxylate(out) + Na+(out) = monocarboxylate(in) + Na+(in).
[ "GOC:ln", "PMID:15322102" ]
null
[]
[]
[]
[]
[]
[ "GO:0005343", "GO:0015355" ]
[]
[]
[]
[ "GO:0005343", "GO:0015355" ]
[]
[]
[]
[]
[]
[]
pg
2018-02-05T10:33:55Z
false
true
1
GO:0140162
140,162
venom-mediated vasodilation by activation of bradykinin receptor signaling pathway
biological_process
A process in which an organism initiates, promotes, or enhances vasodilation via the action of a venom that activates bradykinin-dependent signaling, concomittantly reducing blood pressure in the bitten/stung organism. This can take place via several mechanisms that affect endogenous bradykinin: either increasing its r...
[ "PMID:31370142" ]
null
[ "venom-mediated vasodilation by activation of bradykinin-dependent signaling", "venom-mediated vasodilation through activity of bradykinin" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0044513", "GO:0044551" ]
[]
[]
[]
[ "GO:0044513", "GO:0044551" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30014\" xsd:anyURI" ]
pg
2025-04-01T09:16:39Z
false
true
7
GO:0140163
140,163
venom-mediated suppression of bradykinin-dependent vasodilation
biological_process
A process in which an organism inhibits or disrupts vasodilation via the action of a venom that suppresses bradykinin-dependent signaling.
[ "PMID:21889567", "PMID:31370142" ]
null
[ "venom-mediated vasoconstriction via bradykinin receptor antagonism" ]
[ "RELATED" ]
[]
[]
[]
[ "GO:0044513", "GO:0140134" ]
[]
[]
[]
[ "GO:0044513", "GO:0140134" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30014\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30211\" xsd:anyURI" ]
pg
2025-04-01T09:29:25Z
false
true
5
GO:0140164
140,164
COG complex binding
molecular_function
Binding to a Golgi transport complex, a multisubunit tethering complex of the CATCHR family.
[ "GOC:ha", "PMID:28100664" ]
null
[ "Golgi transport complex binding" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0044877" ]
[]
[]
[]
[ "GO:0044877" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31397\" xsd:anyURI" ]
pg
2018-02-08T11:49:38Z
false
true
8
GO:0140165
140,165
venom-mediated vasodilation by activation of nitric oxide-cGMP-mediated signaling
biological_process
A process in which an organism initiates, promotes, or enhances vasodilation via the action of a venom that activates nitric oxide-cGMP-mediated signaling, concomittantly reducing blood pressure in the bitten/stung organism.
[ "PMID:10512636" ]
null
[ "venom-mediated vasodilation induced by nitric oxide activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0044509", "GO:0044551" ]
[]
[]
[]
[ "GO:0044509", "GO:0044551" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30014\" xsd:anyURI" ]
pg
2025-04-01T09:40:15Z
false
true
1
GO:0140166
140,166
venom-mediated vasodilation via suppression of angiotensin maturation
biological_process
A process in which an organism initiates, promotes, or enhances vasodilation via the action of a venom that prevents angiotensin maturation, concomittantly reducing blood pressure in the bitten/stung organism.
[ "PMID:31370142" ]
null
[ "venom-mediated vasodilation mediated by inhibition of angiotensin-converting enzyme", "venom-mediated vasodilation through perturbation of angiotensin maturation" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0044509", "GO:0044551" ]
[]
[]
[]
[ "GO:0044509", "GO:0044551" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30014\" xsd:anyURI" ]
pg
2025-04-01T09:46:06Z
false
true
6
GO:0140167
140,167
histone locus body assembly
biological_process
The aggregation, arrangement and bonding together of a set of components to form a histone locus body.
[ "PMID:21576393", "PMID:32401666" ]
null
[]
[]
[]
[]
[]
[ "GO:0030575", "GO:0140694" ]
[]
[]
[]
[ "GO:0030575", "GO:0140694" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29908\" xsd:anyURI" ]
pg
2025-04-03T06:13:54Z
false
true
5
GO:0140168
140,168
nuclear ribonucleoprotein granule
cellular_component
A ribonucleoprotein granule located in the nucleus.
[ "PMID:32475683", "PMID:35355287", "PMID:37890457" ]
null
[ "nuclear RNA granule", "nuclear RNP granule" ]
[ "NARROW", "EXACT" ]
[]
[]
[]
[ "GO:0016604", "GO:0035770" ]
[]
[]
[]
[ "GO:0016604", "GO:0035770" ]
[ "GO:0035770", "part_of GO:0005654" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29909\" xsd:anyURI" ]
pg
2025-04-03T06:19:37Z
false
true
6
GO:0140169
140,169
3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity
molecular_function
Catalysis of the reaction: a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+.
[ "EC:1.1.1.357" ]
Note that EC distinguishes stereospecific reactions: EC:1.1.1.213 and EC:1.1.1.50. These are out of scope for GO.
[]
[]
[]
[]
[ "EC:1.1.1.213", "EC:1.1.1.357", "EC:1.1.1.50", "RHEA:34779", "RHEA:34783" ]
[ "GO:0033764" ]
[]
[]
[]
[ "GO:0033764" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch MetaCyc:1.1.1.209-RXN", "skos:exactMatch EC:1.1.1.357", "skos:narrowMatch EC:1.1.1.213", "skos:narrowMatch EC:1.1.1.50", "skos:narrowMatch RHEA:34779", "skos:narrowMatch RHEA:34783", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29921\" xsd:anyURI" ]
pg
2025-04-09T15:19:24Z
false
true
5
GO:0140170
140,170
D-lactate dehydrogenase (FAD) activity
molecular_function
Catalysis of the reaction: (R)-lactate + FAD + H+ = FADH2 + pyruvate.
[ "RHEA:82479" ]
null
[]
[]
[]
[]
[ "RHEA:82479" ]
[ "GO:0047809" ]
[]
[]
[]
[ "GO:0047809" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch RHEA:82479", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30132\" xsd:anyURI" ]
pg
2025-04-17T08:20:22Z
false
true
1
GO:0140171
140,171
L-lactate dehydrogenase activity
molecular_function
Catalysis of the reaction: (S)-lactate + A = AH(2) + pyruvate.
[ "GOC:pg" ]
null
[]
[]
[]
[]
[]
[ "GO:0004457" ]
[]
[]
[]
[ "GO:0004457" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30132\" xsd:anyURI" ]
pg
2025-04-17T08:24:35Z
false
true
5
GO:0140172
140,172
histone H2AT120pho reader activity
molecular_function
A histone reader that recognizes a histone H2A phosphorylated at threonine 120.
[ "PMID:19965387", "PMID:20679485" ]
Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is conserved across all eukaryotes, but corresponds to T119 in Drosophila and S121 in yeast and Tetrahymena. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that eac...
[ "histone H2AS120pho reader activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0140054" ]
[]
[]
[]
[ "GO:0140054" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30130\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30583\" xsd:anyURI" ]
pg
2025-04-17T08:59:19Z
false
true
9
GO:0140173
140,173
histone H2AS139pho reader activity
molecular_function
A histone reader that recognizes a histone H2A phosphorylated at serine 139.
[ "PMID:20679485" ]
Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is conserved across all eukaryotes. This corresponds to H2AS128 in S. pombe and H2AS129 in S. cerevisiae.
[]
[]
[]
[]
[]
[ "GO:0140054" ]
[]
[]
[]
[ "GO:0140054" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30130\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30583\" xsd:anyURI" ]
pg
2025-04-17T09:27:51Z
false
true
1
GO:0140175
140,175
(2R)-2-hydroxyacid dehydrogenase (NAD+) activity
molecular_function
Catalysis of the reaction: a (2R)-2-hydroxycarboxylate + NAD+ = a 2-oxocarboxylate + NADH + H+.
[ "RHEA:35643" ]
null
[]
[]
[]
[]
[ "EC:1.1.1.345", "RHEA:10052", "RHEA:35643", "RHEA:57408", "RHEA:70327", "RHEA:86067", "RHEA:86071" ]
[ "GO:0016616" ]
[]
[]
[]
[ "GO:0016616" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.1.1.345", "skos:exactMatch RHEA:35643", "skos:narrowMatch RHEA:10052", "skos:narrowMatch RHEA:57408", "skos:narrowMatch RHEA:70327", "skos:narrowMatch RHEA:86067", "skos:narrowMatch RHEA:86071", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30138\" xsd:a...
pg
2025-05-20T08:52:20Z
false
true
1
GO:0140176
140,176
positive regulation of pyruvate decarboxylation to acetyl-CoA
biological_process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvat...
[ "PMID:15855260" ]
null
[]
[]
[]
[]
[]
[ "GO:0010510", "GO:0140390" ]
[ "positively_regulates GO:0006086" ]
[ "positively_regulates" ]
[ "GO:0006086" ]
[ "GO:0006086", "GO:0010510", "GO:0140390" ]
[ "GO:0065007", "positively_regulates GO:0006086" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30051\" xsd:anyURI" ]
pg
2025-06-04T08:32:15Z
false
true
5
GO:0140177
140,177
membrane-membrane adaptor activity
molecular_function
The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle.
[ "GOC:curators" ]
null
[]
[]
[]
[]
[]
[ "GO:0060090" ]
[]
[]
[]
[ "GO:0060090" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24964\" xsd:anyURI" ]
pg
2025-06-04T08:36:30Z
false
true
2
GO:0140178
140,178
lumenal side of cis-Golgi network membrane
cellular_component
The leaflet of the cis-Golgi network membrane directly contacts the Golgi lumen, including any protein embedded in, attached to, or peripherally associated with it. This is the site where glycosylation, cargo sorting, or interactions with resident Golgi proteins occur.
[ "PMID:1747103", "PMID:29802621", "PMID:34080016" ]
null
[]
[]
[]
[]
[]
[ "GO:0098576" ]
[ "part_of GO:0033106" ]
[ "part_of" ]
[ "GO:0033106" ]
[ "GO:0033106", "GO:0098576" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30389\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31515\" xsd:anyURI" ]
pg
2025-06-05T08:47:14Z
false
true
2
GO:0140179
140,179
cytoplasmic side of cis-Golgi network membrane
cellular_component
The leaflet of the cis-Golgi network membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. This is the site of interactions with cytosolic proteins, including those for vesicle tethering, fusion, and Golgi-associated trafficking activities.
[ "PMID:1747103", "PMID:23913272", "PMID:34080016", "PMID:34597626" ]
null
[]
[]
[]
[]
[]
[ "GO:0098562" ]
[ "part_of GO:0033106" ]
[ "part_of" ]
[ "GO:0033106" ]
[ "GO:0033106", "GO:0098562" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30388\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31515\" xsd:anyURI" ]
pg
2025-06-05T08:50:47Z
false
true
8
GO:0140180
140,180
centriole scaffold activity
molecular_function
The binding activity of a protein that contributes to the stable formation of a centriole by forming persistent structures, or templates, upon which other centriolar proteins assemble.
[ "PMID:29784964", "PMID:32956907", "PMID:34702818" ]
null
[]
[]
[]
[]
[]
[ "GO:0140378" ]
[]
[]
[]
[ "GO:0140378" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30443\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31499\" xsd:anyURI" ]
pg
2025-06-11T13:59:35Z
false
true
4
GO:0140181
140,181
host-mediated activation of viral RNA-templated transcription
biological_process
A process in which a host organism initiates, promotes, or enhances the normal execution of viral RNA-templated transcription, the synthesis of either RNA on a RNA template.
[ "PMID:18836083" ]
null
[ "positive regulation by host of viral RNA-templated transcription", "positive regulation of viral RNA-templated transcription by host" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0043923" ]
[]
[]
[]
[ "GO:0043923" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30185\" xsd:anyURI" ]
pg
2025-06-11T15:40:26Z
false
true
5
GO:0140182
140,182
recycling of RNA polymerase
biological_process
The process of freeing aborted or stalled RNA polymerase (RNAP), which dissociates it from nucleic acids and allows RNAP to reinitiate another transcription cycle. The freed mRNA is not used for further transcription.
[ "PMID:33339820", "PMID:33339823", "PMID:33339827", "PMID:39384756" ]
null
[]
[]
[]
[]
[]
[ "GO:0019725" ]
[ "part_of GO:0006353" ]
[ "part_of" ]
[ "GO:0006353" ]
[ "GO:0006353", "GO:0019725" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30189\" xsd:anyURI" ]
pg
2025-06-24T09:47:51Z
false
true
9
GO:0140183
140,183
venom-mediated vasoconstriction via activation of endothelin receptor signaling pathway
biological_process
A process in which an organism promotes the narrowing (constriction) of blood vessels, by inhibiting the widening (dilation) of blood vessels in another organism via the action of a venom that activates endothelin receptor signaling pathway, concomittantly increasing blood pressure in the bitten/stung organism.
[ "PMID:16277978" ]
null
[ "venom-mediated vasoconstriction via activation of endothelin signaling pathway", "venom-mediated vasoconstriction via activation of endothelin-dependent signaling", "venom-mediated vasoconstriction via endothelin receptor agonism" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0044514" ]
[]
[]
[]
[ "GO:0044514" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30211\" xsd:anyURI" ]
pg
2025-06-26T08:05:09Z
false
true
5
GO:0140185
140,185
siRNA-mediated silent mating type cassette region heterochromatin formation
biological_process
The formation of heterochromatin into a heterochromatin domain by a process mediated by a small interfering siRNA at the silent mating-type loci.
[ "PMID:39747188" ]
null
[ "siRNA mediated silent mating type cassette region heterochromatin formation", "siRNA-mediated silent-mating type cassette region heterochromatin formation" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0030466", "GO:0141194" ]
[]
[]
[]
[ "GO:0030466", "GO:0141194" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30545\" xsd:anyURI" ]
pg
2025-07-10T11:11:38Z
false
true
7
GO:0140186
140,186
protein N-acyltransferase activity
molecular_function
Catalysis of the reaction: an acyl-CoA + L-lysyl-[protein] = N6-acyl-L-lysyl-[protein] + CoA + H+.
[ "RHEA:53916" ]
null
[ "protein acyltransferase activity" ]
[ "EXACT" ]
[]
[]
[ "RHEA:53916", "RHEA:59764", "RHEA:59796", "RHEA:59800", "RHEA:83531", "RHEA:85279" ]
[ "GO:0016410", "GO:0140096" ]
[]
[]
[]
[ "GO:0016410", "GO:0140096" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch RHEA:53916", "skos:narrowMatch RHEA:59764", "skos:narrowMatch RHEA:59796", "skos:narrowMatch RHEA:59800", "skos:narrowMatch RHEA:83531", "skos:narrowMatch RHEA:85279", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
pg
2025-07-22T09:31:41Z
false
true
9
GO:0140187
140,187
histone H1-4K34 acetyltransferase activity
molecular_function
Catalysis of the reaction: acetyl-CoA + histone H1-4 L-lysine (position 34) = CoA + histone H1-4 N6-acetyl-L-lysine (position 34).
[ "PMID:22465951" ]
null
[]
[]
[]
[]
[]
[ "GO:0160262" ]
[]
[]
[]
[ "GO:0160262" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch RHEA:21992", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30567\" xsd:anyURI" ]
pg
2025-07-22T09:54:23Z
false
true
2
GO:0140188
140,188
histone H1 methyltransferase activity
molecular_function
Catalysis of the reaction: S-adenosyl-L-methionine + a histone H1 = S-adenosyl-L-homocysteine + a methylated histone H1.
[ "PMID:19144645" ]
null
[ "histone H1 methylase activity", "histone H1 methylation" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0042054" ]
[]
[]
[]
[ "GO:0042054" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30567\" xsd:anyURI" ]
pg
2025-07-22T09:58:11Z
false
true
5
GO:0140189
140,189
H1-4K26 methyltransferase activity
molecular_function
Catalysis of the reaction: S-adenosyl-L-methionine + histone H1-4 L-lysine (position 26) = S-adenosyl-L-homocysteine + histone H1-4 N6-methyl-L-lysine (position 26).
[ "PMID:19144645" ]
null
[]
[]
[]
[]
[]
[ "GO:0140188" ]
[]
[]
[]
[ "GO:0140188" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30567\" xsd:anyURI" ]
pg
2025-07-22T12:05:02Z
false
true
1
GO:0140190
140,190
histone H1 kinase activity
molecular_function
Catalysis of the transfer of a phosphate group to a histone H1.
[ "PMID:21511733", "PMID:21852232", "PMID:33238524" ]
null
[]
[]
[]
[]
[]
[ "GO:0035173" ]
[]
[]
[]
[ "GO:0035173" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30567\" xsd:anyURI" ]
pg
2025-07-22T12:34:54Z
false
true
9
GO:0140191
140,191
histone H1-4S187 kinase activity
molecular_function
Catalysis of the reaction: histone H1-4-serine (position 27) + ATP = histone H1-4-phosphoserine (position 27) + ADP.
[ "PMID:21511733" ]
null
[]
[]
[]
[]
[]
[ "GO:0004674", "GO:0140190" ]
[]
[]
[]
[ "GO:0004674", "GO:0140190" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30567\" xsd:anyURI" ]
pg
2025-07-22T12:36:16Z
false
true
5
GO:0140192
140,192
obsolete regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
biological_process
OBSOLETE. Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process.
[ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph" ]
This term was obsoleted because it represents a GO-CAM pathway.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0106070" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25766\" xsd:anyURI" ]
pg
2018-02-15T19:06:38Z
true
true
7
GO:0140193
140,193
obsolete regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process
biological_process
OBSOLETE. Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process.
[ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph" ]
This term was obsoleted because it represents a GO-CAM pathway.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0071877" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25766\" xsd:anyURI" ]
pg
2018-02-15T19:08:49Z
true
true
6
GO:0140194
140,194
obsolete negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process
biological_process
OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process.
[ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph" ]
This term was obsoleted because it represents a GO-CAM model.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0003015", "GO:0071878" ]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25766\" xsd:anyURI" ]
pg
2018-02-15T19:13:02Z
true
true
5
GO:0140195
140,195
obsolete positive regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process
biological_process
OBSOLETE. Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process.
[ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph" ]
This term was obsoleted because it represents a GO-CAM pathway.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0071879" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25766\" xsd:anyURI" ]
pg
2018-02-15T19:13:11Z
true
true
9
GO:0140196
140,196
obsolete positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
biological_process
OBSOLETE. Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process.
[ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0106071" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31254\" xsd:anyURI" ]
pg
2018-02-15T19:13:29Z
true
true
4
GO:0140197
140,197
histone H1-4S27 kinase activity
molecular_function
Catalysis of the reaction: histone H1-4-serine (position 187) + ATP = histone H1-4-phosphoserine (position 187) + ADP.
[ "PMID:21511733", "PMID:21852232", "PMID:33238524" ]
null
[]
[]
[]
[]
[]
[ "GO:0004674", "GO:0140190" ]
[]
[]
[]
[ "GO:0004674", "GO:0140190" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30567\" xsd:anyURI" ]
pg
2025-07-22T12:39:59Z
false
true
5
GO:0140198
140,198
histone H1-4S35 kinase activity
molecular_function
Catalysis of the reaction: histone H1-4-serine (position 35) + ATP = histone H1-4-phosphoserine (position 35) + ADP.
[ "PMID:21852232" ]
null
[]
[]
[]
[]
[]
[ "GO:0004674", "GO:0140190" ]
[]
[]
[]
[ "GO:0004674", "GO:0140190" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30567\" xsd:anyURI" ]
pg
2025-07-22T12:41:02Z
false
true
9
GO:0140199
140,199
obsolete negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
biological_process
OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process.
[ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0003015", "GO:0071878" ]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31254\" xsd:anyURI" ]
pg
2018-02-15T19:31:23Z
true
true
4
GO:0140200
140,200
obsolete adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate
biological_process
OBSOLETE. An adrenergic receptor signaling pathway that modulates the frequency or rate of heart contraction.
[ "GOC:BHF" ]
This term was obsoleted because it represents a GO-CAM pathway.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0071880" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25766\" xsd:anyURI" ]
pg
2018-02-16T14:33:06Z
true
true
4
GO:0140201
140,201
urea import across plasma membrane
biological_process
The directed movement of urea from outside of a cell, across the plasma membrane and into the cytosol.
[ "PMID:17218313" ]
null
[]
[]
[]
[]
[]
[ "GO:0071918", "GO:0098739" ]
[]
[]
[]
[ "GO:0071918", "GO:0098739" ]
[]
[]
[]
[]
[]
[]
pg
2018-02-20T10:15:45Z
false
true
3
GO:0140202
140,202
polyamine import across plasma membrane
biological_process
The directed movement of a polyamine from outside of a cell, across the plasma membrane and into the cytosol.
[ "PMID:17218313" ]
null
[]
[]
[]
[]
[]
[ "GO:0071705", "GO:0098739" ]
[]
[]
[]
[ "GO:0071705", "GO:0098739" ]
[]
[]
[]
[]
[]
[]
pg
2018-02-20T10:24:54Z
false
true
5
GO:0140203
140,203
spermidine import across plasma membrane
biological_process
The directed movement of spermidine from outside of a cell, across the plasma membrane and into the cytosol.
[ "GOC:vw" ]
null
[]
[]
[]
[]
[]
[ "GO:0140202", "GO:1903711" ]
[]
[]
[]
[ "GO:0140202", "GO:1903711" ]
[]
[]
[]
[]
[]
[]
pg
2018-02-21T19:10:07Z
false
true
4
GO:0140204
140,204
pyridoxal import across plasma membrane
biological_process
The directed movement of pyridoxal from outside of a cell, across the plasma membrane and into the cytosol.
[ "GOC:vw" ]
null
[]
[]
[]
[]
[]
[ "GO:0098739", "GO:1903090" ]
[]
[]
[]
[ "GO:0098739", "GO:1903090" ]
[]
[]
[]
[]
[]
[]
pg
2018-02-21T19:17:27Z
false
true
6
GO:0140205
140,205
oligopeptide import across plasma membrane
biological_process
The directed movement of an oligopeptide from outside of a cell, across the plasma membrane and into the cytosol.
[ "PMID:22226946" ]
null
[]
[]
[]
[]
[]
[ "GO:0035672", "GO:0098739" ]
[]
[]
[]
[ "GO:0035672", "GO:0098739" ]
[]
[]
[]
[]
[]
[]
pg
2018-02-22T15:48:21Z
false
true
2
GO:0140206
140,206
dipeptide import across plasma membrane
biological_process
The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol.
[ "PMID:22226946" ]
null
[]
[]
[]
[]
[]
[ "GO:0035442", "GO:0140205" ]
[]
[]
[]
[ "GO:0035442", "GO:0140205" ]
[]
[]
[]
[]
[]
[]
pg
2018-02-22T15:49:19Z
false
true
7
GO:0140207
140,207
tripeptide import across plasma membrane
biological_process
The directed movement of a tripeptide from outside of a cell, across the plasma membrane and into the cytosol.
[ "PMID:22226946" ]
null
[]
[]
[]
[]
[]
[ "GO:0035443", "GO:0140205" ]
[]
[]
[]
[ "GO:0035443", "GO:0140205" ]
[]
[]
[]
[]
[]
[]
pg
2018-02-22T15:49:55Z
false
true
3
GO:0140208
140,208
apoptotic process in response to mitochondrial fragmentation
biological_process
Any apoptotic process that occurs as a result of mitochondrial fragmentation.
[ "PMID:18940801" ]
null
[ "apoptosis in response to mitochondrial fragmentation" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0006915" ]
[]
[]
[]
[ "GO:0006915" ]
[]
[]
[]
[]
[]
[]
pg
2018-03-08T16:54:17Z
false
true
8
GO:0140209
140,209
zinc ion import into endoplasmic reticulum
biological_process
The directed import of zinc(2+) from the cytosol, across the endoplasmic reticulum membrane, into the endoplasmic reticulum.
[ "PMID:11886869", "PMID:29529046" ]
This term covers zinc(2+) import *across* the endoplasmic reticulum membrane through a channel or pore. It does not cover import via vesicle fusion with endoplasmic reticulum membrane, as in this case transport does not involve crossing the membrane.
[ "zinc ion import across endoplasmic reticulum", "zinc ion import into ER", "zinc(2+) import across endoplasmic reticulum", "zinc(2+) import into endoplasmic reticulum" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0046967", "GO:0062111" ]
[]
[]
[]
[ "GO:0046967", "GO:0062111" ]
[]
[]
[]
[]
[]
[]
pg
2018-03-19T10:40:01Z
false
true
6