LiteFold/GO · Datasets at Hugging Face

GO:0140210

140,210

protein transport along microtubule to kinetochore

biological_process

Any process in which a protein is transported to the kinetochore along a microtubule.

[ "PMID:25472718" ]

null

[]

[ "GO:0034501", "GO:0070199", "GO:0098840" ]

[]

[ "GO:0034501", "GO:0070199", "GO:0098840" ]

[]

pg

2018-03-22T07:05:21Z

false

true

5

GO:0140211

140,211

folic acid:proton symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: folic acid(out) + H+(out) = folic acid(in) + H+(in). The main folic acid symporter is the Proton-Coupled Folate Transporter (PCFT/SLC46A1), which has similar affinity for transport of reduced folates (5-methy...

[ "PMID:24745983" ]

null

[]

[ "Reactome:R-HSA-200646 \"Cytosolic folate export across the plasma membrane\"", "Reactome:R-HSA-200729 \"SLC46A1 transports FOLA from extracellular region to cytosol\"", "TC:2.A.1.50.1" ]

[ "GO:0008517", "GO:0015295" ]

[]

[ "GO:0008517", "GO:0015295" ]

[]

pg

2018-03-30T08:00:09Z

false

true

8

GO:0140212

140,212

regulation of long-chain fatty acid import into cell

biological_process

Any process that modulates the frequency, rate or extent of long-chain fatty acid import into a cell.

[ "PMID:28178239" ]

null

[]

[ "GO:2000191" ]

[ "regulates GO:0044539" ]

[ "regulates" ]

[ "GO:0044539" ]

[ "GO:0044539", "GO:2000191" ]

[ "GO:0065007", "regulates GO:0044539" ]

[]

pg

2018-04-10T15:10:41Z

false

true

3

GO:0140213

140,213

negative regulation of long-chain fatty acid import into cell

biological_process

Any process that stops, prevents or reduces the frequency, rate or extent of long-chain fatty acid import into a cell.

[ "PMID:28178239" ]

null

[]

[ "GO:0140212", "GO:2000192" ]

[ "negatively_regulates GO:0044539" ]

[ "negatively_regulates" ]

[ "GO:0044539" ]

[ "GO:0044539", "GO:0140212", "GO:2000192" ]

[ "GO:0065007", "negatively_regulates GO:0044539" ]

[]

pg

2018-04-10T15:13:28Z

false

true

6

GO:0140214

140,214

positive regulation of long-chain fatty acid import into cell

biological_process

Any process that activates or increases the frequency, rate or extent of long-chain fatty acid import into a cell.

[ "PMID:28178239" ]

null

[]

[ "GO:0140212", "GO:2000193" ]

[ "positively_regulates GO:0044539" ]

[ "positively_regulates" ]

[ "GO:0044539" ]

[ "GO:0044539", "GO:0140212", "GO:2000193" ]

[ "GO:0065007", "positively_regulates GO:0044539" ]

[]

pg

2018-04-10T15:15:03Z

false

true

3

GO:0140215

140,215

regulation of D-aspartate import across plasma membrane

biological_process

Any process that modulates the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol.

[ "PMID:27663541" ]

null

[]

[ "GO:0010958", "GO:0032890" ]

[ "regulates GO:0070779" ]

[ "regulates" ]

[ "GO:0070779" ]

[ "GO:0010958", "GO:0032890", "GO:0070779" ]

[ "GO:0065007", "regulates GO:0070779" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15041\" xsd:anyURI" ]

pg

2018-04-11T15:33:35Z

false

true

4

GO:0140216

140,216

negative regulation of D-aspartate import across plasma membrane

biological_process

Any process that stops, prevents or reduces the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol.

[ "PMID:27663541" ]

null

[]

[ "GO:0032891", "GO:0034763", "GO:0051956", "GO:0140215" ]

[ "negatively_regulates GO:0070779" ]

[ "negatively_regulates" ]

[ "GO:0070779" ]

[ "GO:0032891", "GO:0034763", "GO:0051956", "GO:0070779", "GO:0140215" ]

[ "GO:0065007", "negatively_regulates GO:0070779" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15041\" xsd:anyURI" ]

pg

2018-04-11T15:43:25Z

false

true

4

GO:0140217

140,217

positive regulation of D-aspartate import across plasma membrane

biological_process

Any process that activates or increases the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol.

[ "PMID:27663541" ]

null

[]

[ "GO:0032892", "GO:0034764", "GO:0051957", "GO:0140215" ]

[ "positively_regulates GO:0070779" ]

[ "positively_regulates" ]

[ "GO:0070779" ]

[ "GO:0032892", "GO:0034764", "GO:0051957", "GO:0070779", "GO:0140215" ]

[ "GO:0065007", "positively_regulates GO:0070779" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15041\" xsd:anyURI" ]

pg

2018-04-11T15:45:22Z

false

true

4

GO:0140218

140,218

histone methacryltransferase activity

molecular_function

Catalysis of the reaction: 2-methylpropenoyl-CoA + L-lysyl-[protein] = N6-methacrylyl-L-lysyl-[protein] + CoA + H+. Methacryl-CoA is a synonym of 2-methylpropenoyl-CoA.

[ "PMID:34961760", "PMID:40339582" ]

null

[ "histone 2-methylpropenoyl transferase activity" ]

[ "EXACT" ]

[]

[ "GO:0140993" ]

[]

[ "GO:0140993" ]

[]

[ "skos:broadMatch RHEA:83547", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30567\" xsd:anyURI" ]

pg

2025-07-22T13:00:24Z

false

true

4

GO:0140219

140,219

histone methacryllysine demethacrylase activity

molecular_function

Catalysis of the reaction: N6-methacrylyl-L-lysyl-[histone] + H2O = 2-methylprop-2-enoate + L-lysyl-[histone].

[ "PMID:34961760" ]

null

[]

[ "GO:0140993" ]

[]

[ "GO:0140993" ]

[]

[ "skos:broadMatch RHEA:83551", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30567\" xsd:anyURI" ]

pg

2025-07-22T13:14:18Z

false

true

6

GO:0140220

140,220

pathogen-containing vacuole

cellular_component

A membrane-bound intracellular compartment that is formed upon internalization of a pathogen into a host cell, and in which the pathogen resides.

[ "PMID:10560000", "PMID:26842840" ]

null

[ "pathogen inclusion", "pathogen-containing compartment" ]

[ "RELATED", "RELATED" ]

[]

[ "GO:0033643" ]

[]

[ "GO:0033643" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15580\" xsd:anyURI" ]

pg

2018-04-20T06:02:14Z

false

true

9

GO:0140221

140,221

pathogen-containing vacuole membrane

cellular_component

Host-derived membrane of a pathogen-containing vacuole.

[ "PMID:10560000", "PMID:26842840" ]

null

[ "pathogen inclusion membrane", "pathogen-containing compartment membrane" ]

[ "RELATED", "EXACT" ]

[]

[ "GO:0016020" ]

[ "part_of GO:0140220" ]

[ "part_of" ]

[ "GO:0140220" ]

[ "GO:0016020", "GO:0140220" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15580\" xsd:anyURI" ]

pg

2018-04-20T06:18:25Z

false

true

2

GO:0140222

140,222

pathogen-containing vacuole lumen

cellular_component

The enclosed volume within the sealed membrane of a pathogen-containing vacuole.

[ "PMID:10560000", "PMID:26842840" ]

null

[ "lumen of a pathogen-containing vacuole", "pathogen inclusion lumen", "pathogen-containing compartment lumen", "pathogen-containing vacuolar lumen" ]

[ "EXACT", "RELATED", "EXACT", "EXACT" ]

[]

[ "GO:0031974" ]

[ "part_of GO:0140220" ]

[ "part_of" ]

[ "GO:0140220" ]

[ "GO:0031974", "GO:0140220" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15580\" xsd:anyURI" ]

pg

2018-04-20T06:24:02Z

false

true

9

GO:0140223

140,223

general transcription initiation factor activity

molecular_function

A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the pr...

[ "GOC:txnOH-2018" ]

Usage guidance: The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors are the constitutive machinery required for transcription initiation.

[ "basal transcription factor activity", "general transcription factor activity", "GTF activity" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "goslim_drosophila", "goslim_euk_cellular_processes_ribbon", "goslim_generic", "goslim_plant_ribbon", "goslim_prokaryote_ribbon" ]

[]

[ "GO:0003674" ]

[ "part_of GO:0006351" ]

[ "part_of" ]

[ "GO:0006351" ]

[ "GO:0003674", "GO:0006351" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20253\" xsd:anyURI" ]

pg

2018-05-24T07:51:23Z

false

true

6

GO:0140224

140,224

SLAC complex

cellular_component

A protein complex that regulates Arp2/3 complex-mediated actin nucleation.

[ "GOC:lnp", "PMID:22973053" ]

null

[]

[ "GO:0032991" ]

[]

[ "GO:0032991" ]

[]

pg

2018-05-29T09:54:08Z

false

true

1

GO:0140225

140,225

DNA topoisomerase III-beta-TDRD3 complex

cellular_component

A protein complex that has DNA topoisomerase type I and RNA topoisomerase activities.

[ "GOC:lnp", "PMID:23912945", "PMID:28176834" ]

null

[ "Top3-beta-TDRD3 complex" ]

[ "EXACT" ]

[]

[ "GO:0032991" ]

[]

[ "GO:0032991" ]

[]

pg

2018-05-29T10:05:33Z

false

true

4

GO:0140226

140,226

RNA topoisomerase activity

molecular_function

Catalysis of the transient cleavage and passage of individual RNA strands or double helices through one another, resulting a topological transformation in RNA.

[ "GOC:lnp", "PMID:23912945", "PMID:27257063" ]

null

[]

[ "GO:0120545", "GO:0140098" ]

[]

[ "GO:0120545", "GO:0140098" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29695\" xsd:anyURI" ]

pg

2018-05-29T11:06:37Z

false

true

5

GO:0140227

140,227

serotonin-gated cation-selective signaling pathway

biological_process

The series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.

[ "GOC:bhm", "PMID:25392484", "PMID:27764665" ]

null

[ "5-HT-gated cation-selective signaling pathway", "5-HT-gated cation-selective signalling pathway", "5-hydroxytryptamine-gated cation-selective signaling pathway", "5-hydroxytryptamine-gated cation-selective signalling pathway", "serotonin-gated cation-selective signalling pathway" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0007210", "GO:1990806" ]

[ "has_part GO:0022850" ]

[ "has_part" ]

[ "GO:0022850" ]

[ "GO:0007210", "GO:0022850", "GO:1990806" ]

[]

pg

2018-06-02T13:34:51Z

false

true

5

GO:0140228

140,228

histone benzoyllysine debenzoylase activity

molecular_function

Catalysis of the reaction: N(6)-benzoyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-benzoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein].

[ "PMID:34961760" ]

null

[]

[ "GO:0140993" ]

[]

[ "GO:0140993" ]

[]

[ "skos:broadMatch RHEA:83535", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30567\" xsd:anyURI" ]

pg

2025-07-22T13:37:04Z

false

true

7

GO:0140229

140,229

histone isonicotinyllysine deisonicotinylase activity

molecular_function

Catalysis of the reaction: N(6)-isonicotinyl-L-lysyl-[protein] + H2O = isonicotinate + L-lysyl-[protein].

[ "PMID:34545082" ]

null

[]

[ "GO:0140993" ]

[]

[ "GO:0140993" ]

[]

[ "skos:broadMatch RHEA:83543", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30567\" xsd:anyURI" ]

pg

2025-07-22T13:38:30Z

false

true

4

GO:0140230

140,230

histone isonicotinyltransferase activity

molecular_function

Catalysis of the reaction: isonicotinyl-CoA + histone = coA + N(6)-isonicotinyl-histone.

[ "PMID:34545082" ]

null

[]

[ "GO:0140993" ]

[]

[ "GO:0140993" ]

[]

[ "skos:broadMatch RHEA:83539", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30567\" xsd:anyURI" ]

pg

2025-07-22T13:41:06Z

false

true

7

GO:0140231

140,231

anterograde axonal transport of neurotransmitter receptor complex

biological_process

The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons.

[ "PMID:28680963" ]

null

[]

[ "goslim_synapse" ]

[]

[ "GO:0097120", "GO:0099637", "GO:0099641" ]

[]

[ "GO:0097120", "GO:0099637", "GO:0099641" ]

[]

pg

2018-07-09T09:41:37Z

false

true

4

GO:0140232

140,232

obsolete intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential

molecular_function

OBSOLETE. Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential.

[ "PMID:21358644" ]

The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.

[ "intracellular cAMP activated cation channel activity involved in regulation of presynaptic membrane potential" ]

[ "EXACT" ]

[]

[ "GO:0005222" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31205\" xsd:anyURI" ]

pg

2018-07-09T11:30:40Z

true

6

GO:0140233

140,233

obsolete intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential

molecular_function

OBSOLETE. Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential.

[ "GOC:pvn" ]

This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.

[ "intracellular cAMP activated cation channel activity involved in regulation of postsynaptic membrane potential" ]

[ "EXACT" ]

[]

[ "GO:0005222" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31205\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31254\" xsd:anyURI" ]

pg

2018-07-09T11:31:18Z

true

3

GO:0140234

140,234

histone H3K23 ubiquitin ligase activity

molecular_function

Catalysis of the transfer of a ubiquitin molecule to histone 3 at the lysine-23 residue.

[ "PMID:40680746" ]

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...

[]

[ "GO:0141055" ]

[]

[ "GO:0141055" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30613\" xsd:anyURI" ]

pg

2025-07-22T14:33:56Z

false

true

9

GO:0140235

140,235

RNA polyadenylation at postsynapse

biological_process

A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse.

[ "PMID:22727665" ]

Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

[]

[ "goslim_synapse" ]

[]

[ "GO:0006396" ]

[]

[ "GO:0006396" ]

[]

pg

2018-07-13T12:03:28Z

false

true

2

GO:0140236

140,236

translation at presynapse

biological_process

Translation that occurs at the presynapse.

[ "PMID:27321671" ]

Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

[]

[ "goslim_synapse" ]

[]

[ "GO:0140241" ]

[ "occurs_in GO:0098793" ]

[ "occurs_in" ]

[ "GO:0098793" ]

[ "GO:0098793", "GO:0140241" ]

[ "GO:0006412", "occurs_in GO:0098793" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/synapse/issues/216\" xsd:anyURI" ]

pg

2018-07-13T13:00:33Z

false

true

8

GO:0140237

140,237

translation at presynapse, modulating chemical synaptic transmission

biological_process

Translation that occurs at the presynapse, and that modulates chemical synaptic transmission.

[ "PMID:27321671" ]

Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

[]

[ "goslim_synapse" ]

[]

[ "GO:0140236" ]

[ "regulates GO:0007268" ]

[ "regulates" ]

[ "GO:0007268" ]

[ "GO:0007268", "GO:0140236" ]

[ "GO:0006412", "occurs_in GO:0098793", "regulates GO:0007268" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/synapse/issues/216\" xsd:anyURI" ]

pg

2018-07-13T13:07:23Z

false

true

5

GO:0140238

140,238

presynaptic endocytosis

biological_process

A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.

[ "PMID:24719103" ]

Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

[]

[ "goslim_synapse" ]

[]

[ "GO:0006897", "GO:0051649", "GO:0099003" ]

[ "occurs_in GO:0098793" ]

[ "occurs_in" ]

[ "GO:0098793" ]

[ "GO:0006897", "GO:0051649", "GO:0098793", "GO:0099003" ]

[ "GO:0006897", "occurs_in GO:0098793" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/synapse/issues/230\" xsd:anyURI" ]

pg

2018-07-15T07:33:55Z

false

true

7

GO:0140239

140,239

postsynaptic endocytosis

biological_process

A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.

[ "PMID:12839988" ]

Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

[]

[ "goslim_synapse" ]

[]

[ "GO:0006897", "GO:0051649", "GO:0099003" ]

[ "occurs_in GO:0098794" ]

[ "occurs_in" ]

[ "GO:0098794" ]

[ "GO:0006897", "GO:0051649", "GO:0098794", "GO:0099003" ]

[ "GO:0006897", "occurs_in GO:0098794" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/synapse/issues/230\" xsd:anyURI" ]

pg

2018-07-15T07:38:27Z

false

true

5

GO:0140240

140,240

perforant pathway to dendrate granule cell synapse

cellular_component

A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus.

[ "PMID:22727665", "PMID:29199135" ]

null

[ "perforant pathway to DG granule cell synapse" ]

[ "EXACT" ]

[]

[ "goslim_synapse" ]

[]

[ "GO:0045202" ]

[]

[ "GO:0045202" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/synapse/issues/234\" xsd:anyURI" ]

pg

2018-07-15T08:21:43Z

false

true

6

GO:0140241

140,241

translation at synapse

biological_process

Translation that occurs at the synapse.

[ "PMID:23083742" ]

Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

[]

[ "goslim_synapse" ]

[]

[ "GO:0006412" ]

[ "occurs_in GO:0045202" ]

[ "occurs_in" ]

[ "GO:0045202" ]

[ "GO:0006412", "GO:0045202" ]

[ "GO:0006412", "occurs_in GO:0045202" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/synapse/issues/210\" xsd:anyURI" ]

pg

2018-07-15T09:23:12Z

false

true

2

GO:0140242

140,242

translation at postsynapse

biological_process

Translation that occurs at the postsynapse.

[ "PMID:20427644" ]

Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

[]

[ "goslim_synapse" ]

[]

[ "GO:0140241" ]

[ "occurs_in GO:0098794" ]

[ "occurs_in" ]

[ "GO:0098794" ]

[ "GO:0098794", "GO:0140241" ]

[ "GO:0006412", "occurs_in GO:0098794" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/synapse/issues/210\" xsd:anyURI" ]

pg

2018-07-15T09:26:27Z

false

true

8

GO:0140243

140,243

regulation of translation at synapse

biological_process

Any process that regulates translation occurring at the synapse.

[ "PMID:20427644" ]

Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

[]

[ "goslim_synapse" ]

[]

[ "GO:0006417" ]

[ "occurs_in GO:0045202" ]

[ "occurs_in" ]

[ "GO:0045202" ]

[ "GO:0006417", "GO:0045202" ]

[ "GO:0065007", "occurs_in GO:0045202", "regulates GO:0006412" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/synapse/issues/210\" xsd:anyURI" ]

pg

2018-07-15T09:38:26Z

false

true

9

GO:0140244

140,244

regulation of translation at presynapse

biological_process

Any process that regulates translation occurring at the presynapse.

[ "PMID:20427644" ]

Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

[]

[ "goslim_synapse" ]

[]

[ "GO:0140243" ]

[ "occurs_in GO:0098793" ]

[ "occurs_in" ]

[ "GO:0098793" ]

[ "GO:0098793", "GO:0140243" ]

[ "GO:0065007", "occurs_in GO:0098793", "regulates GO:0006412" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/synapse/issues/210\" xsd:anyURI" ]

pg

2018-07-15T09:38:33Z

false

true

8

GO:0140246

140,246

protein catabolic process at synapse

biological_process

The chemical reactions and pathways resulting in the breakdown of a protein at a synapse.

[ "PMID:17062563" ]

Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

[]

[ "goslim_synapse" ]

[]

[ "GO:0030163" ]

[ "occurs_in GO:0045202" ]

[ "occurs_in" ]

[ "GO:0045202" ]

[ "GO:0030163", "GO:0045202" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/synapse/issues/210\" xsd:anyURI" ]

pg

2018-07-15T10:12:51Z

false

true

7

GO:0140247

140,247

protein catabolic process at presynapse

biological_process

The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse.

[ "PMID:27764673" ]

Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

[]

[ "goslim_synapse" ]

[]

[ "GO:0140246" ]

[ "occurs_in GO:0098793" ]

[ "occurs_in" ]

[ "GO:0098793" ]

[ "GO:0098793", "GO:0140246" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/synapse/issues/204\" xsd:anyURI" ]

pg

2018-07-15T10:23:49Z

false

true

3

GO:0140248

140,248

histone H3K18 ubiquitin ligase activity

molecular_function

Catalysis of the transfer of a ubiquitin molecule to histone 3 at the lysine-18 residue.

[ "PMID:27595565" ]

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...

[]

[ "GO:0141055" ]

[]

[ "GO:0141055" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30613\" xsd:anyURI" ]

pg

2025-07-22T14:46:18Z

false

true

1

GO:0140251

140,251

regulation protein catabolic process at presynapse

biological_process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse.

[ "PMID:27764673" ]

Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

[]

[ "goslim_synapse" ]

[]

[ "GO:0140250" ]

[ "occurs_in GO:0098793" ]

[ "occurs_in" ]

[ "GO:0098793" ]

[ "GO:0098793", "GO:0140250" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/synapse/issues/204\" xsd:anyURI" ]

pg

2018-07-15T10:35:39Z

false

true

9

GO:0140252

140,252

regulation protein catabolic process at postsynapse

biological_process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse.

[ "PMID:17062563" ]

Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

[]

[ "goslim_synapse" ]

[]

[ "GO:0140250" ]

[ "occurs_in GO:0098794" ]

[ "occurs_in" ]

[ "GO:0098794" ]

[ "GO:0098794", "GO:0140250" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/synapse/issues/204\" xsd:anyURI" ]

pg

2018-07-15T10:35:56Z

false

true

5

GO:0140254

140,254

histone H3K18ub reader activity

molecular_function

A histone reader that recognizes a histone H3 ubiquitinated at lysine 18.

[ "PMID:29053958" ]

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...

[ "H3K18ub modified histone binding" ]

[ "NARROW" ]

[]

[ "GO:0140006" ]

[]

[ "GO:0140006" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30613\" xsd:anyURI" ]

pg

2025-07-22T14:47:43Z

false

true

2

GO:0140255

140,255

regulation of cellular response to phosphate starvation

biological_process

Any process that modulates the frequency, rate or extent of cellular response to phosphate starvation.

[ "PMID:29414789" ]

null

[]

[ "GO:0032107", "GO:0080135" ]

[ "regulates GO:0016036" ]

[ "regulates" ]

[ "GO:0016036" ]

[ "GO:0016036", "GO:0032107", "GO:0080135" ]

[ "GO:0065007", "regulates GO:0016036" ]

[]

pg

2018-09-07T17:11:42Z

false

true

1

GO:0140256

140,256

negative regulation of cellular response to phosphate starvation

biological_process

Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to phosphate starvation.

[ "PMID:29414789" ]

null

[]

[ "GO:0032108", "GO:0048523", "GO:0140255" ]

[ "negatively_regulates GO:0016036" ]

[ "negatively_regulates" ]

[ "GO:0016036" ]

[ "GO:0016036", "GO:0032108", "GO:0048523", "GO:0140255" ]

[ "GO:0065007", "negatively_regulates GO:0016036" ]

[]

pg

2018-09-07T17:11:42Z

false

true

8

GO:0140257

140,257

histone H3K23ub reader activity

molecular_function

A histone reader that recognizes a histone H3 ubiquitinated at lysine 23.

[ "PMID:29053958" ]

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...

[ "H3K23ub modified histone binding" ]

[ "NARROW" ]

[]

[ "GO:0140006" ]

[]

[ "GO:0140006" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30613\" xsd:anyURI" ]

pg

2025-07-22T14:48:55Z

false

true

7

GO:0140258

140,258

histone H3K14ub reader activity

molecular_function

A histone reader that recognizes a histone H3 ubiquitinated at lysine 14.

[ "PMID:29053958", "PMID:34524082" ]

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...

[ "H3-K14ub reader activity", "H3K14ub modified histone binding" ]

[ "EXACT", "NARROW" ]

[]

[ "GO:0140006" ]

[]

[ "GO:0140006" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30144\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30613\" xsd:anyURI" ]

pg

2025-07-22T14:50:19Z

false

true

2

GO:0140259

140,259

PRC1 complex binding

molecular_function

Binding to a PRC1 complex.

[ "PMID:15280237" ]

null

[]

[ "GO:0044877" ]

[]

[ "GO:0044877" ]

[]

pg

2018-09-10T16:48:18Z

false

true

8

GO:0140260

140,260

mitochondrial proton-transporting ATP synthase complex binding

molecular_function

Binding to a mitochondrial proton-transporting ATP synthase complex.

[ "PMID:12110673" ]

null

[]

[ "GO:0044877" ]

[]

[ "GO:0044877" ]

[]

pg

2018-09-10T19:38:26Z

false

true

5

GO:0140261

140,261

BCOR complex

cellular_component

A protein-containing complex that monoubiquitinates histone H2A on K119, thus it facilitates the maintenance of the transcriptionally repressive state of some genes, such as BCL6. It consists of the corepressor BCOR or BCORL1, a Polycomb group (PcG) and a SCF ubiquitin ligase subcomplexes. In mammals, the core subunits...

[ "PMID:16943429", "PMID:22325352", "PMID:24515802" ]

null

[ "BCL6 corepressor (BCOR) complex", "BCOR/BCORL1 complex", "non-canonical BCOR-PRC1.1 complex", "non-canonical PRC1-BCOR complex", "PRC1.1 complex" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0000152" ]

[]

[ "GO:0000152" ]

[]

pg

2018-09-11T09:35:05Z

false

true

6

GO:0140262

140,262

mRNA cap binding complex binding

molecular_function

Binding to a mRNA cap binding complex.

[ "PMID:16938833" ]

null

[]

[ "GO:0044877" ]

[]

[ "GO:0044877" ]

[]

pg

2018-09-12T12:56:16Z

false

true

5

GO:0140263

140,263

keratan sulfate-I proteoglycan biosynthetic process

biological_process

The chemical reactions and pathways resulting in the formation of keratan sulfate I (KS-I), N-linked via a GlcNAc attached to an asparigine residue in the target protein.

[ "PMID:29340594" ]

null

[ "N-linked GlcNac-keratan sulfate-I proteoglycan biosynthetic process" ]

[ "EXACT" ]

[]

[ "GO:0006487", "GO:0018146" ]

[]

[ "GO:0006487", "GO:0018146" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30595\" xsd:anyURI" ]

pg

2025-07-23T09:39:33Z

false

true

7

GO:0140264

140,264

keratan sulfate-II proteoglycan biosynthetic process

biological_process

The chemical reactions and pathways resulting in the formation of keratan sulfate II (KS-II), O-linked via a GalNAc attached to a serine or a threonine residue in the target protein.

[ "PMID:29340594" ]

null

[ "O-linked GalNAc-keratan sulfate-II proteoglycan biosynthetic process" ]

[ "EXACT" ]

[]

[ "GO:0016266", "GO:0018146" ]

[]

[ "GO:0016266", "GO:0018146" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30595\" xsd:anyURI" ]

pg

2025-07-23T09:39:41Z

false

true

3

GO:0140265

140,265

keratan sulfate-III proteoglycan biosynthetic process

biological_process

The chemical reactions and pathways resulting in the formation of keratan sulfate III (KS-III), O-linked via a mannose attached to a serine or a threonine residue in the target protein.

[ "PMID:29340594" ]

null

[ "O-linked man-keratan sulfate-III proteoglycan biosynthetic process" ]

[ "EXACT" ]

[]

[ "GO:0018146", "GO:0035269" ]

[]

[ "GO:0018146", "GO:0035269" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30595\" xsd:anyURI" ]

pg

2025-07-23T09:40:52Z

false

true

8

GO:0140266

140,266

Woronin body

cellular_component

Peroxisome-derived dense-core vesicle that seals septal pores upon hyphal lysis to prevent excessive cytoplasmic loss. It is specific to several genera of filamentous ascomycetes.

[ "PMID:12640443", "PMID:15155882", "PMID:18227279", "PMID:20707002", "PMID:23882222" ]

null

[]

[ "GO:0042579" ]

[]

[ "GO:0042579" ]

[]

pg

2018-09-24T14:53:37Z

false

true

9

GO:0140268

140,268

endoplasmic reticulum-plasma membrane contact site

cellular_component

A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes.

[ "PMID:23041194", "PMID:27955928", "PMID:29290560", "PMID:29782498", "PMID:30012696" ]

null

[ "endoplasmic reticulum-plasma membrane contact junction", "EPCS", "ER-plasma membrane contact site", "ER-PM contact site" ]

[ "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0044232" ]

[]

[ "GO:0044232" ]

[]

pg

2018-09-26T09:29:41Z

false

true

7

GO:0140269

140,269

arthro-series glucosylceramide biosynthetic process

biological_process

The chemical reactions and pathways resulting in the formation of arthro-series glucosylceramides that begins with the synthesis of a tetrasaccharide core GalNAc-beta-1,4-GlcNAc-beta-1,3-Man-beta-1,4Glc-ceramide. This core can be further elongated with the sequential addition of various carbohydrate units.

[ "PMID:35536927" ]

null

[]

[ "MetaCyc:PWY-8612" ]

[ "GO:0006688" ]

[]

[ "GO:0006688" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30616\" xsd:anyURI" ]

pg

2025-07-24T12:01:12Z

false

true

6

GO:0140270

140,270

gluconate import across plasma membrane

biological_process

The directed movement of gluconate from outside of a cell, across the plasma membrane and into the cytosol.

[ "PMID:10735857" ]

null

[]

[ "GO:0035429", "GO:0098739" ]

[]

[ "GO:0035429", "GO:0098739" ]

[]

pg

2018-10-01T08:47:35Z

false

true

9

GO:0140272

140,272

exogenous protein binding

molecular_function

Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein.

[ "PMID:28861068" ]

Note that as GO captures normal processes, it may be that exogenous proteins interactions are normal for one of the participating species but not the other. Therefore reciprocal annotations should not be made without confirming that it is physiological relevant.

[]

[ "GO:0005515" ]

[]

[ "GO:0005515" ]

[]

pg

2018-10-01T10:03:21Z

false

true

7

GO:0140273

140,273

repair of mitotic kinetochore microtubule attachment defect

biological_process

The mitotic cell cycle process where kinetochore microtubule attachment defects are corrected.

[ "PMID:15525536" ]

null

[ "correction of mitotic kinetochore microtubule attachment defects", "repair of mitotic kinetochore microtubule attachment defects" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0140274", "GO:1903047" ]

[ "part_of GO:0007080" ]

[ "part_of" ]

[ "GO:0007080" ]

[ "GO:0007080", "GO:0140274", "GO:1903047" ]

[]

pg

2018-10-01T11:29:24Z

false

true

9

GO:0140274

140,274

repair of kinetochore microtubule attachment defect

biological_process

The cell cycle process where kinetochore microtubule attachment defects are corrected.

[ "PMID:15525536" ]

null

[ "correction of kinetochore microtubule attachment defects", "repair of kinetochore microtubule attachment defects" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0022402" ]

[]

[ "GO:0022402" ]

[]

pg

2018-10-01T11:30:19Z

false

true

1

GO:0140275

140,275

MIB complex

cellular_component

A mitochondrial intermembrane space bridging complex consisting of components of the MICOS complex in the inner mitochondrial membrane, the SAM complex in the outer membrane, a conserved DNAJ protein (human DNAJC11) and Metaxin 1.

[ "PMID:26477565" ]

null

[ "mitochondrial intermembrane space bridging complex", "mitofilin complex" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0098800" ]

[]

[ "GO:0098800" ]

[]

pg

2018-10-01T17:10:27Z

false

true

9

GO:0140277

140,277

endoplasmic reticulum N-glycan trimming

biological_process

The trimming, in the ER, of the protein newly attached N-glycan by glucosidases and mannosidases to produce high mannose-type N-glycans.

[ "PMID:30858582" ]

null

[ "ER N-glycan trimming" ]

[ "EXACT" ]

[]

[ "GO:0006491" ]

[]

[ "GO:0006491" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30595\" xsd:anyURI" ]

pg

2025-07-29T08:56:54Z

false

true

3

GO:0140280

140,280

negative regulation of mitotic division septum assembly

biological_process

Any process that stops, prevents or reduces the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.

[ "PMID:22786806" ]

null

[ "down regulation of division septum formation involved in mitotic cell cycle", "down regulation of formation of division septum involved in mitotic cell cycle", "down regulation of mitotic division septum assembly", "down regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle", ...

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "NARROW", "NARROW", "NARROW", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0010974", "GO:0140279", "GO:1903437" ]

[ "negatively_regulates GO:0140278" ]

[ "negatively_regulates" ]

[ "GO:0140278" ]

[ "GO:0010974", "GO:0140278", "GO:0140279", "GO:1903437" ]

[ "GO:0065007", "negatively_regulates GO:0140278" ]

[]

pg

2018-10-08T10:03:22Z

false

true

4

GO:0140281

140,281

positive regulation of mitotic division septum assembly

biological_process

Any process that activates or increases the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.

[ "PMID:22786806" ]

null

[ "activation of division septum formation involved in mitotic cell cycle", "activation of formation of division septum involved in mitotic cell cycle", "activation of mitotic division septum assembly", "activation of septin assembly and septum biosynthesis involved in mitotic cell cycle", "activation of sept...

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "RELATED", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0010973", "GO:0140279", "GO:1903438" ]

[ "positively_regulates GO:0140278" ]

[ "positively_regulates" ]

[ "GO:0140278" ]

[ "GO:0010973", "GO:0140278", "GO:0140279", "GO:1903438" ]

[ "GO:0065007", "positively_regulates GO:0140278" ]

[]

pg

2018-10-08T10:03:30Z

false

true

9

GO:0140282

140,282

carbon-nitrogen ligase activity on lipid II

molecular_function

Catalysis of the reaction: L-glutamine + lipid II + ATP + H2O = L-glutamate + beta-D-GlcNAc(1->4)-Mur2Ac(oyl-L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + ADP + phosphate.

[ "PMID:22291598", "PMID:30093673", "PMID:30154570", "RHEA:57928" ]

null

[ "L-glutamate--lipid II transaminase activity", "undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl pentapeptide amidotransferase (glutamine-hydrolyzing) activity" ]

[ "EXACT", "EXACT" ]

[]

[ "EC:6.3.5.13", "RHEA:57928" ]

[ "GO:0016884" ]

[]

[ "GO:0016884" ]

[]

[ "skos:exactMatch EC:6.3.5.13", "skos:exactMatch RHEA:57928", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/16422\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

pg

2018-10-08T19:12:57Z

false

true

7

GO:0140283

140,283

HUSH complex

cellular_component

A protein complex that mediates transcriptional silencing of mobile genetic elements, such as retroviruses and transposable elements. In human, it is composed of TASOR, PPHLN1 and MPHOSPH8.

[ "PMID:39013473", "PMID:39489739" ]

null

[]

[ "GO:0005677" ]

[]

[ "GO:0005677" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30773\" xsd:anyURI" ]

pg

2025-08-28T12:34:30Z

false

true

1

GO:0140284

140,284

endoplasmic reticulum-endosome membrane contact site

cellular_component

A contact site between the endoplasmic reticulum membrane and the endosome membrane.

[ "PMID:24105263", "PMID:30220460" ]

null

[ "ER-endosome membrane contact site" ]

[ "EXACT" ]

[]

[ "GO:0044232" ]

[]

[ "GO:0044232" ]

[]

pg

2018-10-30T10:29:28Z

false

true

6

GO:0140285

140,285

endosome fission

biological_process

The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane.

[ "PMID:25416943", "PMID:30220460" ]

null

[]

[ "GO:0048285" ]

[]

[ "GO:0048285" ]

[]

pg

2018-10-30T10:36:33Z

false

true

5

GO:0140286

140,286

HUSH2 complex

cellular_component

A protein complex that mediates transcriptional silencing of interferon-stimulated genes. In human, it is composed of TASOR2, PPHLN1 and MPHOSPH8.

[ "PMID:26022416", "PMID:39013473", "PMID:39489739" ]

null

[]

[ "GO:0005677" ]

[]

[ "GO:0005677" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30773\" xsd:anyURI" ]

pg

2025-08-28T12:34:30Z

false

true

4

GO:0140287

140,287

hydrazine dehydrogenase activity

molecular_function

Catalysis of the reaction: hydrazine + 4 Fe(III)-[cytochrome c] = N2 + 4 Fe(II)-[cytochrome c] + 4 H+.

[ "RHEA:23232" ]

null

[]

[ "EC:1.7.2.8", "MetaCyc:1.7.99.8-RXN", "RHEA:23232" ]

[ "GO:0016662" ]

[]

[ "GO:0016662" ]

[]

[ "skos:exactMatch EC:1.7.2.8", "skos:exactMatch RHEA:23232", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30814\" xsd:anyURI" ]

pg

2025-09-09T14:28:09Z

false

true

3

GO:0140288

140,288

GBAF complex

cellular_component

A SWI/SNF subcomplex that incorporates two mutually exclusive paralogs, GLTSCR1 (glioma tumor suppressor candidate region gene 1) or GLTSCR1L (GLTSCR1-like), BRD9 (bromodomain-containing 9) and the BAF subunits BAF155, BAF60, SS18, BAF53a, and BRG1/BRM.

[ "PMID:29374058" ]

null

[]

[ "GO:0070603" ]

[]

[ "GO:0070603" ]

[]

pg

2018-11-20T09:13:52Z

false

true

9

GO:0140289

140,289

obsolete protein mono-ADP-ribosylation

biological_process

OBSOLETE. The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids.

[ "PMID:25043379" ]

This term was obsoleted because it represents a molecular function.

[]

[ "GO:0003950" ]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23249\" xsd:anyURI" ]

pg

2018-11-22T13:52:54Z

true

1

GO:0140290

140,290

peptidyl-serine ADP-deribosylation

biological_process

The removal of ADP-ribose from ADP-ribosylserine.

[ "PMID:28650317", "PMID:29234005" ]

null

[]

[ "GO:0051725" ]

[]

[ "GO:0051725" ]

[]

pg

2018-11-22T14:32:30Z

false

true

1

GO:0140291

140,291

peptidyl-glutamate ADP-deribosylation

biological_process

The removal of ADP-ribose from ADP-ribosylglutamate.

[ "PMID:23481255" ]

null

[]

[ "GO:0051725" ]

[]

[ "GO:0051725" ]

[]

pg

2018-11-22T14:34:24Z

false

true

3

GO:0140292

140,292

ADP-ribosylserine hydrolase activity

molecular_function

Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose.

[ "PMID:28650317", "PMID:29234005", "RHEA:58256" ]

null

[]

[ "RHEA:58256" ]

[ "GO:0016799", "GO:0140096" ]

[]

[ "GO:0016799", "GO:0140096" ]

[]

[ "skos:exactMatch RHEA:58256", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28476\" xsd:anyURI" ]

pg

2018-11-22T14:35:39Z

false

true

2

GO:0140294

140,294

NAD DNA ADP-ribosyltransferase activity

molecular_function

Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA.

[ "PMID:27471034", "PMID:29361132", "PMID:29520010" ]

null

[]

[ "GO:0016763" ]

[]

[ "GO:0016763" ]

[]

pg

2018-11-22T15:45:35Z

false

true

1

GO:0140295

140,295

pathogen-derived receptor ligand activity

molecular_function

The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity.

[ "PMID:20601497" ]

Note that this term is meant to annotate effectors for which the evolved activity is to act as a ligand to activate (for necrotrophs) or suppress (for biotrophs) the host immune system. It should not be used to annotate PAMPs (pathogen-associated molecular pattern molecules) or similar types of microbial proteins recog...

[ "host-selective toxin", "innate receptor ligand activity", "necrotrophic effector" ]

[ "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:0048018" ]

[]

[ "GO:0048018" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/16656\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18042\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19194\" xsd:anyURI" ]

pg

2018-11-26T13:30:21Z

false

true

1

GO:0140296

140,296

general transcription initiation factor binding

molecular_function

Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation.

[ "GOC:txnOH-2018" ]

null

[]

[ "GO:0008134" ]

[]

[ "GO:0008134" ]

[]

pg

2018-11-28T12:48:06Z

false

true

5

GO:0140297

140,297

DNA-binding transcription factor binding

molecular_function

Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.

[ "GOC:txnOH-2018" ]

null

[ "activating transcription factor binding", "repressing transcription factor binding", "transcription activator binding" ]

[ "RELATED", "RELATED", "RELATED" ]

[ "GO:0001107", "GO:0033613", "GO:0070491" ]

[]

[ "GO:0008134" ]

[]

[ "GO:0008134" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19354\" xsd:anyURI" ]

pg

2018-11-28T12:48:20Z

false

true

3

GO:0140298

140,298

endocytic iron import into cell

biological_process

Uptake of iron into a cell via binding to an extracellular receptor, which is internalized by endocytosis.

[ "PMID:23092063" ]

null

[ "iron import into cell by endocytosis" ]

[ "EXACT" ]

[]

[ "GO:0006898", "GO:0033212" ]

[]

[ "GO:0006898", "GO:0033212" ]

[]

pg

2018-12-10T10:31:31Z

false

true

7

GO:0140299

140,299

molecular sensor activity

molecular_function

Binding to a molecule and eliciting a change in the protein's activity in response to the intracellular level of that molecule.

[ "PMID:26328879" ]

null

[ "small molecular sensor activity", "small molecule sensing activity", "small molecule sensor activity" ]

[ "EXACT", "EXACT", "NARROW" ]

[]

[ "goslim_drosophila", "goslim_euk_cellular_processes_ribbon", "goslim_generic", "goslim_plant_ribbon", "goslim_prokaryote", "goslim_prokaryote_ribbon" ]

[ "Reactome:R-HSA-9854368 \"ROS,RNS oxidize ACO2:4Fe-4S\"" ]

[ "GO:0098772" ]

[]

[ "GO:0098772" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28772\" xsd:anyURI" ]

pg

2018-12-10T14:30:28Z

false

true

1

GO:0140300

140,300

serine import into mitochondrion

biological_process

The process in which serine is transported from the cytosol into the mitochondrial matrix.

[ "PMID:30442778" ]

null

[]

[ "GO:0003333", "GO:0032329", "GO:0170036", "GO:1905039" ]

[]

[ "GO:0003333", "GO:0032329", "GO:0170036", "GO:1905039" ]

[]

pg

2018-12-13T15:17:50Z

false

true

6

GO:0140301

140,301

pollen-stigma interaction

biological_process

The interactions (or cell to cell communication) that occur between the pollen grain (male gametophyte) and the stigmatic tissues of the female sporophyte after the pollen reaches the stigmatic papillae.

[ "PMID:27899537" ]

null

[]

[ "GO:0009875" ]

[]

[ "GO:0009875" ]

[]

pg

2019-02-22T13:58:21Z

false

true

3

GO:0140302

140,302

pollen-style interaction

biological_process

The interactions (or cell to cell communication) that occur between the male gametophyte (pollen/pollen tube) and the stylar tissues of the female sporophyte.

[ "PMID:27899537" ]

null

[]

[ "GO:0009875" ]

[]

[ "GO:0009875" ]

[]

pg

2019-02-22T13:59:33Z

false

true

7

GO:0140303

140,303

intramembrane lipid carrier activity

molecular_function

Enables the transport of a lipid from a region of a membrane to a different region on the same membrane.

[ "PMID:16828084" ]

null

[ "flippase activity", "intramembrane lipid transporter activity", "translocase activity" ]

[ "RELATED", "BROAD", "BROAD" ]

[]

[ "GO:0005215", "GO:0005319" ]

[ "part_of GO:0034204" ]

[ "part_of" ]

[ "GO:0034204" ]

[ "GO:0005215", "GO:0005319", "GO:0034204" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17648\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19477\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31454\" xsd:anyURI" ]

pg

2019-03-01T20:14:09Z

false

true

2

GO:0140304

140,304

hydrazine synthase activity

molecular_function

Catalysis of the reaction: hydrazine + 3 Fe(III)-[cytochrome c] + H2O = nitric oxide + 3 Fe(II)-[cytochrome c] + NH4+ + 2 H+.

[ "RHEA:49816" ]

null

[]

[ "EC:1.7.2.7", "MetaCyc:RXN-11175", "RHEA:49816" ]

[ "GO:0016662" ]

[]

[ "GO:0016662" ]

[]

[ "skos:exactMatch EC:1.7.2.7", "skos:exactMatch RHEA:49816", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30814\" xsd:anyURI" ]

pg

2025-09-09T14:34:43Z

false

true

5

GO:0140305

140,305

hydroxylamine dehydrogenase activity

molecular_function

Catalysis of the reaction: hydroxylamine + 4 Fe(III)-[cytochrome c] + H2O = 4 Fe(II)-[cytochrome c] + nitrite + 5 H+.

[ "RHEA:45032" ]

null

[]

[ "EC:1.7.2.6", "MetaCyc:HAONITRO-RXN", "RHEA:45032" ]

[ "GO:0016662" ]

[]

[ "GO:0016662" ]

[]

[ "skos:exactMatch EC:1.7.2.6", "skos:exactMatch RHEA:45032", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30814\" xsd:anyURI" ]

pg

2025-09-09T14:44:04Z

false

true

8

GO:0140306

140,306

lipoprotein releasing activity

molecular_function

The activity of recognizing mature outer membrane lipoproteins in the inner membrane and releasing from the inner membrane so that they can be transported across the periplasmic space to their target location, the outer membrane. This function exists in diderm bacteria, mediated by the LolCDE complex.

[ "PMID:10783239", "PMID:21670534" ]

null

[]

[ "GO:0140318" ]

[]

[ "GO:0140318" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17058\" xsd:anyURI" ]

pg

2019-03-22T14:25:43Z

false

true

9

GO:0140307

140,307

phospholipase C-activating N-formyl peptide-activated signaling pathway

biological_process

A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by an N-formyl peptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. chemotaxis. N-formyl peptides include N-formylmethionyl-leucyl-phenylalanine (fMLF, fM...

[ "PMID:10466071", "PMID:22728827", "PMID:23994464" ]

null

[ "fMLP-activated G protein-coupled receptor signaling pathway" ]

[ "NARROW" ]

[]

[ "GO:0007200" ]

[]

[ "GO:0007200" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27490\" xsd:anyURI" ]

pg

2025-10-20T14:16:02Z

false

true

5

GO:0140308

140,308

insulin-like growth factor binding receptor complex

cellular_component

A plasma membrane-localized protein complex that binds insulin-like growth factors (IGF1 or IGF2). This class includes both signaling receptor complexes, such as the insulin-like growth factor 1 receptor (IGF1R) complex, which possesses intrinsic tyrosine kinase activity and initiates intracellular signaling cascades u...

[ "PMID:17475626", "PMID:27140600", "PMID:31594955", "PMID:35749888" ]

null

[ "IGF-binding receptor complex" ]

[ "EXACT" ]

[]

[ "GO:0098802" ]

[]

[ "GO:0098802" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30922\" xsd:anyURI" ]

pg

2025-10-20T15:19:56Z

false

true

1

GO:0140309

140,309

unfolded protein holdase activity

molecular_function

A protein carrier activity that binds to a protein in an unfolded state and escorts it to an acceptor molecule or to a specific location. The unfolded protein carrier prevents aggregation of the target protein while it's being delivers to its final destination.

[ "PMID:39488384" ]

Note that an holdase binds an unfolded protein and keeps it unfolded, unlike a protein folding chaperone, which binds an unfolded protein to fold it.

[ "holdase", "holdase-carrier chaperone", "unfolded protein carrier activity" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0140597" ]

[]

[ "GO:0140597" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30552\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31601\" xsd:anyURI" ]

pg

2025-11-03T13:14:32Z

false

true

8

GO:0140310

140,310

positive regulation of peptidoglycan biosynthetic process

biological_process

Any process that increases the rate, frequency, or extent of peptidoglycan biosynthetic process.

[ "PMID:37688380" ]

null

[]

[ "GO:0010557", "GO:0010981" ]

[ "positively_regulates GO:0009252" ]

[ "positively_regulates" ]

[ "GO:0009252" ]

[ "GO:0009252", "GO:0010557", "GO:0010981" ]

[ "GO:0065007", "positively_regulates GO:0009252" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30927\" xsd:anyURI" ]

pg

2025-11-04T10:19:39Z

false

true

2

GO:0140311

140,311

protein sequestering activity

molecular_function

Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.

[ "PMID:1493333" ]

null

[]

[ "Reactome:R-HSA-1678694 \"Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans\"" ]

[ "GO:0140313" ]

[ "has_part GO:0005515" ]

[ "has_part" ]

[ "GO:0005515" ]

[ "GO:0005515", "GO:0140313" ]

[ "GO:0140313", "has_part GO:0005515" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/16157\" xsd:anyURI" ]

pg

2019-03-26T14:34:16Z

false

true

5

GO:0140312

140,312

cargo adaptor activity

molecular_function

Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery.

[ "PMID:25795254" ]

null

[ "endocytic adaptor activity" ]

[ "NARROW" ]

[ "GO:0098748" ]

[]

[ "Reactome:R-HSA-203565 \"eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP\"", "Reactome:R-HSA-203662 \"eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2\"" ]

[ "GO:0030674" ]

[ "part_of GO:0016192" ]

[ "part_of" ]

[ "GO:0016192" ]

[ "GO:0016192", "GO:0030674" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17553\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19454\" xsd:anyURI" ]

pg

2019-03-26T17:01:45Z

false

true

9

GO:0140313

140,313

molecular sequestering activity

molecular_function

Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.

[ "PMID:13130076" ]

null

[]

[ "goslim_drosophila", "goslim_euk_cellular_processes_ribbon", "goslim_generic", "goslim_plant_ribbon", "goslim_prokaryote", "goslim_prokaryote_ribbon" ]

[ "Reactome:R-HSA-203553 \"eNOS binds NOSIP\"", "Reactome:R-HSA-203680 \"eNOS:NOSIP translocation from caveolae to intracellular compartments\"", "Reactome:R-HSA-2404134 \"RBP4:atROL binds TTR\"", "Reactome:R-HSA-3245898 \"TCN1 binds correnoids in the circulation\"" ]

[ "GO:0003674" ]

[]

[ "GO:0003674" ]

[]

pg

2019-03-28T10:00:25Z

false

true

7

GO:0140314

140,314

calcium ion sequestering activity

molecular_function

Binding to a calcium ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.

[ "PMID:13130076" ]

null

[]

[ "GO:0140487" ]

[ "has_part GO:0005509" ]

[ "has_part" ]

[ "GO:0005509" ]

[ "GO:0005509", "GO:0140487" ]

[ "GO:0140313", "has_part GO:0005509" ]

[]

pg

2019-03-28T10:07:18Z

false

true

6

GO:0140315

140,315

iron ion sequestering activity

molecular_function

Binding to an iron ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.

[ "PMID:27780864" ]

null

[]

[ "GO:0140487" ]

[ "has_part GO:0005506" ]

[ "has_part" ]

[ "GO:0005506" ]

[ "GO:0005506", "GO:0140487" ]

[ "GO:0140313", "has_part GO:0005506" ]

[]

pg

2019-03-28T10:10:33Z

false

true

5

GO:0140316

140,316

obsolete vesicular transport adaptor activity

molecular_function

OBSOLETE. Binding directly to sorting signals in the cytosolic tails of transmembrane cargos (or transmembrane cargo receptors serving as recognition interfaces for lumenal cargos), to concentrate them into vesicles or tubules for transport via intracellular vesicular transport or the secretory pathway.

[ "PMID:25795254" ]

Thi sterm was obsoleted because it represented an unnecessary grouping class.

[]

pg

2019-03-28T12:03:57Z

true

8

GO:0140317

140,317

export across cell outer membrane

biological_process

The directed movement of a substance across the outer membrane in cells with two membranes.

[ "PMID:15968039" ]

null

[]

[ "GO:0055085" ]

[]

[ "GO:0055085" ]

[]

pg

2019-04-01T08:12:23Z

false

true

9

GO:0140318

140,318

protein transporter activity

molecular_function

Directly binding to a specific protein and delivering it to a specific cellular location.

[ "PMID:18706423" ]

Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation.

[ "protein carrier activity", "protein transport chaperone" ]

[ "RELATED", "RELATED" ]

[]

[ "Reactome:R-HSA-2248891 \"M6PR transports activated ARSA to the lysosome\"", "Reactome:R-HSA-9662747 \"iRHOM2 transports ADAM17 from ER to the Golgi-network\"", "Reactome:R-HSA-9662818 \"iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane\"" ]

[ "GO:0005215" ]

[]

[ "GO:0005215" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17073\" xsd:anyURI" ]

pg

2019-04-01T10:41:38Z

false

true

2

GO:0140319

140,319

receptor decoy activity

molecular_function

Binding and sequestering a specific receptor ligand to prevent it from binding to its regular receptor.

[ "Wikipedia:Decoy_receptors" ]

null

[ "decoy death receptor activity", "decoy receptor" ]

[ "NARROW", "EXACT" ]

[ "GO:0005040" ]

[]

[ "GO:0140313" ]

[]

[ "GO:0140313" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17069\" xsd:anyURI" ]

pg

2019-04-02T10:57:46Z

false

true

9