LiteFold/GO · Datasets at Hugging Face

GO:0140320

140,320

PAMP receptor decoy activity

molecular_function

Binding and sequestering PAMP ligands in order to prevent them from binding and activating to the host PAMP receptor. Usually this activity is encoded by a symbiont or a pathogen to prevent activation of the host innate immune response.

[ "PMID:20724636" ]

null

[ "pathogen-associated molecular pattern receptor decoy activity", "pattern recognition receptor decoy activity" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0140319" ]

[]

[ "GO:0140319" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17069\" xsd:anyURI" ]

pg

2019-04-02T11:07:13Z

false

true

7

GO:0140321

140,321

symbiont-mediated suppression of host autophagy

biological_process

A process in which a symbiont inhibits or disrupts the normal execution of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.

[ "GOC:pg" ]

null

[ "negative regulation by symbiont of host autophagy", "suppression of host autophagy" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0075071" ]

[]

[ "GO:0075071" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17055\" xsd:anyURI" ]

pg

2019-04-03T09:21:48Z

false

true

6

GO:0140322

140,322

A1-type glycerophospholipase activity

molecular_function

A glycerophospholipase activity that cleaves the fatty acid attached to the sn-1 position of the glycerol group of a glycerophospholipid.

[ "PMID:30109646" ]

null

[]

[ "GO:0004620", "GO:0052689" ]

[]

[ "GO:0004620", "GO:0052689" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30258\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31049\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31078\" xsd:anyURI", "term_tracker_item \"https://gi...

pg

2025-11-07T09:02:05Z

false

true

5

GO:0140323

140,323

obsolete solute:monoatomic anion antiporter activity

molecular_function

OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(in) + solute(out) = anion(out) + solute(in).

[ "GOC:pg" ]

This term was obsoleted because it is an unnecessary grouping class.

[ "solute:anion antiporter activity" ]

[ "EXACT" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22962\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24479\" xsd:anyURI" ]

pg

2019-04-03T16:23:14Z

true

9

GO:0140324

140,324

lysophospholipase C activity

molecular_function

Hydrolysis of a lysoglycerophospholipid at the first phosphodiester bond between the phosphate and glycerol.

[ "PMID:32917725" ]

null

[]

[ "RHEA:86375", "RHEA:86379" ]

[ "GO:0004629" ]

[]

[ "GO:0004629" ]

[]

[ "skos:narrowMatch RHEA:86375", "skos:narrowMatch RHEA:86379", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30949\" xsd:anyURI" ]

pg

2025-11-10T12:35:51Z

false

true

7

GO:0140325

140,325

negative regulation of protein localization to medial cortex

biological_process

Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the medial cortex.

[ "PMID:30853434" ]

null

[]

[ "GO:0106011", "GO:1903077", "GO:1904777" ]

[ "negatively_regulates GO:0071574" ]

[ "negatively_regulates" ]

[ "GO:0071574" ]

[ "GO:0071574", "GO:0106011", "GO:1903077", "GO:1904777" ]

[ "GO:0065007", "negatively_regulates GO:0071574" ]

[]

pg

2019-04-17T11:58:27Z

false

true

5

GO:0140326

140,326

ATPase-coupled intramembrane lipid carrier activity

molecular_function

Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases.

[ "PMID:16828084" ]

null

[ "aminophospholipid-transporting ATPase", "ATPase-coupled intramembrane lipid transporter activity", "ATPase-coupled phospholipid transporter activity", "ATPase-dependent phospholipid transporter activity", "phospholipid flippase activity", "phospholipid translocating ATPase activity", "phospholipid-tran...

[ "RELATED", "BROAD", "RELATED", "RELATED", "NARROW", "RELATED", "RELATED", "RELATED" ]

[ "GO:0004012", "GO:0008557" ]

[]

[ "EC:7.6.2.1", "MetaCyc:3.6.3.1-RXN", "Reactome:R-HSA-939763 \"P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane\"", "Reactome:R-HSA-947591 \"P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane\"" ]

[ "GO:0140303", "GO:0140657" ]

[]

[ "GO:0140303", "GO:0140657" ]

[]

[ "skos:broadMatch RHEA:66132", "skos:exactMatch EC:7.6.2.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17648\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21612\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontolo...

pg

2019-04-29T12:42:26Z

false

true

6

GO:0140327

140,327

flippase activity

molecular_function

Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.

[ "PMID:20043909", "PMID:25284293", "Wikipedia:Flippase" ]

Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-se...

[ "flippase activity (exoplasmic to cytosolic leaflet)" ]

[ "EXACT" ]

[]

[ "GO:0140326" ]

[]

[ "GO:0140326" ]

[]

[ "skos:broadMatch RHEA:66132" ]

pg

2019-04-29T12:51:21Z

false

true

2

GO:0140328

140,328

floppase activity

molecular_function

Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP.

[ "PMID:20043909", "PMID:25284293", "Wikipedia:Flippase" ]

Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-se...

[ "floppase activity (cytosolic to exoplasmic leaflet)" ]

[ "EXACT" ]

[]

[ "GO:0140326" ]

[]

[ "GO:0140326" ]

[]

[ "skos:broadMatch RHEA:66132" ]

pg

2019-04-29T12:58:53Z

false

true

3

GO:0140330

140,330

xenobiotic detoxification by transmembrane export across the cell outer membrane

biological_process

A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell through the outer membrane.

[ "PMID:11948170" ]

null

[]

[ "GO:0042908", "GO:0140317" ]

[ "part_of GO:0098754" ]

[ "part_of" ]

[ "GO:0098754" ]

[ "GO:0042908", "GO:0098754", "GO:0140317" ]

[]

pg

2019-05-03T10:35:57Z

false

true

7

GO:0140331

140,331

aminophospholipid translocation

biological_process

The movement of an aminophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.

[ "GOC:pg" ]

null

[]

[ "GO:0015917", "GO:0045332" ]

[]

[ "GO:0015917", "GO:0045332" ]

[]

pg

2019-05-10T13:46:34Z

false

true

4

GO:0140332

140,332

lipopolysaccharide transfer activity

molecular_function

Removes a lipopolysaccharide (LPS) from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane.

[ "PMID:24639492" ]

null

[ "intermembrane lipopolysaccharide transfer activity", "intermembrane lipopolysaccharide transporter activity", "intermembrane LPS transporter activity", "lipopolysaccharide carrier activity" ]

[ "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0120013" ]

[ "part_of GO:0015920" ]

[ "part_of" ]

[ "GO:0015920" ]

[ "GO:0015920", "GO:0120013" ]

[]

pg

2019-05-13T08:17:35Z

false

true

8

GO:0140333

140,333

glycerophospholipid flippase activity

molecular_function

Catalysis of the movement of a glycerophospholipid from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.

[ "PMID:26212235" ]

null

[ "glycerophospholipid flippase activity (exoplasmic to cytosolic leaflet)" ]

[ "EXACT" ]

[]

[ "GO:0140327" ]

[]

[ "GO:0140327" ]

[]

[ "skos:broadMatch RHEA:66132" ]

pg

2019-05-13T11:14:56Z

false

true

5

GO:0140335

140,335

GPI anchor phospholipase C activity

molecular_function

Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol, by cleavage of the first phosphodiester bond between the phosphate and glycerol.

[ "PMID:23329048" ]

null

[ "glycoprotein phospholipase C activity", "glycosylphosphatidyl inositol-anchor protein phospholipase C activity", "GPI-PLC activity" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "RHEA:86259" ]

[ "GO:0004629" ]

[]

[ "GO:0004629" ]

[]

[ "skos:narrowMatch RHEA:86259", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28868\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31078\" xsd:anyURI" ]

pg

2025-11-11T08:44:01Z

false

true

9

GO:0140336

140,336

glycosylphosphatidylinositol phospholipase D activity

molecular_function

Catalysis of the reaction: a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H+.

[ "RHEA:10832" ]

null

[ "GPI phospholipase D activity", "phosphatidylinositol phospholipase D activity" ]

[ "EXACT", "BROAD" ]

[]

[ "RHEA:10832" ]

[ "GO:0004630" ]

[]

[ "GO:0004630" ]

[]

[ "skos:broadMatch EC:3.1.4.50", "skos:exactMatch RHEA:10832", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28868\" xsd:anyURI" ]

pg

2025-11-11T15:59:09Z

false

true

5

GO:0140338

140,338

sphingomyelin transfer activity

molecular_function

Removes a sphingomyelin from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane.

[ "PMID:9132017" ]

null

[ "sphingomyelin carrier activity", "sphingosine transmembrane transporter activity" ]

[ "EXACT", "BROAD" ]

[ "GO:0010175" ]

[]

[ "GO:0120014", "GO:0120016" ]

[]

[ "GO:0120014", "GO:0120016" ]

[]

pg

2019-05-16T11:31:58Z

false

true

2

GO:0140339

140,339

phosphatidylglycerol transfer activity

molecular_function

Directly binding to phosphatidylglycerol and delivering it either to an acceptor molecule or to a specific location.

[ "PMID:9132017" ]

null

[ "phosphatidylglycerol carrier activity" ]

[ "EXACT" ]

[]

[ "GO:0120014" ]

[]

[ "GO:0120014" ]

[]

pg

2019-05-16T11:34:45Z

false

true

4

GO:0140340

140,340

cerebroside transfer activity

molecular_function

Directly binding to a cerebroside and delivering it either to an acceptor molecule or to a specific location.

[ "PMID:9132017" ]

null

[ "cerebroside carrier activity" ]

[ "EXACT" ]

[]

[ "GO:0017089", "GO:0120017" ]

[]

[ "GO:0017089", "GO:0120017" ]

[]

pg

2019-05-16T11:37:31Z

false

true

4

GO:0140341

140,341

phosphatidylethanolamine floppase activity

molecular_function

Catalysis of the movement of phosphatidylethanolamine from the cytosolic to the exoplasmic leaflet of a membrane, using energy from the hydrolysis of ATP.

[ "PMID:10029989" ]

null

[ "phosphatidylethanolamine floppase activity (cytosolic to exoplasmic leaflet)" ]

[ "EXACT" ]

[]

[ "GO:0140328" ]

[]

[ "GO:0140328" ]

[]

[ "skos:broadMatch RHEA:66132" ]

pg

2019-05-16T11:40:45Z

false

true

9

GO:0140342

140,342

venom-mediated perturbation of heart contraction

biological_process

A process in which an organism alters or subverts the heart contractility in another organism via the action of a venom.

[ "PMID:38167790" ]

null

[]

[ "GO:0140134" ]

[]

[ "GO:0140134" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31096\" xsd:anyURI" ]

pg

2025-11-20T10:56:34Z

false

true

8

GO:0140343

140,343

phosphatidylserine transfer activity

molecular_function

Removes phosphatidylserine from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane.

[ "PMID:26206935" ]

null

[ "intermembrane phosphatidylserine carrier activity" ]

[ "NARROW" ]

[]

[ "GO:0120014" ]

[]

[ "GO:0120014" ]

[]

pg

2019-05-16T11:46:19Z

false

true

8

GO:0140344

140,344

triglyceride transfer activity

molecular_function

Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location.

[ "PMID:23475612" ]

null

[ "triglyceride carrier activity" ]

[ "EXACT" ]

[]

[ "GO:0120013" ]

[]

[ "GO:0120013" ]

[]

pg

2019-05-16T11:53:59Z

false

true

2

GO:0140346

140,346

phosphatidylserine flippase activity

molecular_function

Catalysis of the movement of phosphatidylserine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.

[ "PMID:11870854" ]

null

[ "phosphatidylserine flippase activity (exoplasmic to cytosolic leaflet)" ]

[ "EXACT" ]

[]

[ "GO:0015247", "GO:0140333" ]

[]

[ "GO:0015247", "GO:0140333" ]

[]

[ "skos:broadMatch RHEA:66132" ]

pg

2019-05-16T13:44:23Z

false

true

6

GO:0140347

140,347

N-retinylidene-phosphatidylethanolamine flippase activity

molecular_function

Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.

[ "PMID:10412977" ]

null

[ "N-retinylidene-phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaflet)" ]

[ "EXACT" ]

[]

[ "RHEA:67188", "RHEA:67192" ]

[ "GO:0140327" ]

[]

[ "GO:0140327" ]

[]

[ "skos:broadMatch RHEA:66132", "skos:narrowMatch RHEA:67188", "skos:narrowMatch RHEA:67192", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27059\" xsd:anyURI" ]

pg

2019-05-16T13:44:51Z

false

true

5

GO:0140348

140,348

lysophosphatidylcholine flippase activity

molecular_function

Catalysis of the movement of lysophosphatidylcholine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.

[ "PMID:26945070" ]

null

[ "lysophosphatidylcholine flippase activity (exoplasmic to cytosolic leaflet)" ]

[ "EXACT" ]

[]

[ "GO:0140333" ]

[]

[ "GO:0140333" ]

[]

[ "skos:broadMatch RHEA:66132" ]

pg

2019-05-16T13:45:17Z

false

true

1

GO:0140349

140,349

laminin network

cellular_component

A supramolecular network that forms mainly through linkages of the short laminin arms between the N-terminal regions of one alpha, one beta, and one gamma chain. The laminin network associates with the collagen network to create the stable, sheet-like structure of the basement membrane ECM.

[ "PMID:1577869", "PMID:21421915", "PMID:23263632", "PMID:28187500" ]

null

[ "laminin complex" ]

[ "BROAD" ]

[]

[ "GO:0099080" ]

[ "part_of GO:0140144" ]

[ "part_of" ]

[ "GO:0140144" ]

[ "GO:0099080", "GO:0140144" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31053\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31490\" xsd:anyURI" ]

pg

2025-12-01T12:38:57Z

false

true

1

GO:0140350

140,350

inchworm-type cell migration

biological_process

A type of amoeboid cell migration involving minimal contact between the cell and the surface, with the cell body standing upright and twisting, followed by rapid reattachment for directed movement.

[ "PMID:40712579" ]

null

[]

[ "GO:0001667" ]

[]

[ "GO:0001667" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31169\" xsd:anyURI" ]

pg

2025-12-09T15:04:11Z

false

true

5

GO:0140351

140,351

glycosylceramide flippase activity

molecular_function

Catalysis of the movement of glycosylceramide from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP. Glycosylceramides are ceramides containing a functional group derived from a sugar.

[ "PMID:30530492" ]

null

[ "galactocerebroside flippase activity", "galactosylceramide flippase activity", "glucosylceramide flippase activity", "glycoceramide flippase activity", "glycosylceramide flippase activity (exoplasmic to cytosolic leaflet)" ]

[ "NARROW", "NARROW", "NARROW", "EXACT", "EXACT" ]

[]

[ "GO:0046624", "GO:0140327" ]

[]

[ "GO:0046624", "GO:0140327" ]

[]

[ "skos:broadMatch RHEA:66132" ]

pg

2019-05-20T13:29:48Z

false

true

7

GO:0140352

140,352

export from cell

biological_process

The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis.

[ "GOC:pg" ]

null

[ "efflux" ]

[ "BROAD" ]

[]

[ "GO:0006810", "GO:0009987" ]

[]

[ "GO:0006810", "GO:0009987" ]

[]

pg

2019-05-22T11:20:45Z

false

true

8

GO:0140353

140,353

lipid export from cell

biological_process

The directed movement of a lipid from a cell, into the extracellular region.

[ "GOC:pg" ]

null

[ "lipid efflux" ]

[ "BROAD" ]

[]

[ "GO:0006869", "GO:0140352" ]

[]

[ "GO:0006869", "GO:0140352" ]

[]

pg

2019-05-22T11:33:07Z

false

true

5

GO:0140354

140,354

lipid import into cell

biological_process

The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.

[ "GOC:pg" ]

null

[ "lipid uptake" ]

[ "BROAD" ]

[]

[ "GO:0006869" ]

[]

[ "GO:0006869" ]

[]

pg

2019-05-22T11:38:15Z

false

true

2

GO:0140355

140,355

cargo receptor ligand activity

molecular_function

The activity of a gene product that interacts with a cargo receptor and initiates endocytosis.

[ "PMID:15797858" ]

null

[ "cargo" ]

[ "RELATED" ]

[]

[ "Reactome:R-HSA-3000074 \"TCN2 binds RCbl in the circulation\"", "Reactome:R-HSA-3000120 \"CBLIF binds RCbl\"", "Reactome:R-HSA-3132759 \"TCN1 binds RCbl\"" ]

[ "GO:0005515" ]

[]

[ "GO:0005515" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17391\" xsd:anyURI" ]

pg

2019-05-27T09:56:50Z

false

true

7

GO:0140356

140,356

L-lyxonate dehydratase activity

molecular_function

Catalysis of the reaction: L-lyxonate =2-dehydro-3-deoxy-L-arabinonate + H2O.

[ "RHEA:62436" ]

null

[]

[ "EC:4.2.1.176", "MetaCyc:RXN-15590", "RHEA:62436" ]

[ "GO:0016836" ]

[]

[ "GO:0016836" ]

[]

[ "skos:exactMatch EC:4.2.1.176", "skos:exactMatch MetaCyc:RXN-15590", "skos:exactMatch RHEA:62436", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31257\" xsd:anyURI" ]

pg

2025-12-23T12:45:43Z

false

true

5

GO:0140357

140,357

heme export from vacuole to cytoplasm

biological_process

The directed movement of heme from inside the vacuole across the vacuolar membrane and into the cytosol.

[ "PMID:28193844" ]

null

[]

[ "GO:0010496", "GO:0034486", "GO:0035351" ]

[]

[ "GO:0010496", "GO:0034486", "GO:0035351" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17407\" xsd:anyURI" ]

pg

2019-05-28T07:40:48Z

false

true

8

GO:0140358

140,358

P-type transmembrane transporter activity

molecular_function

Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon disso...

[ "PMID:18075584", "PMID:25918123" ]

null

[ "E1-E2 ATPase", "P-type ATPase" ]

[ "EXACT", "EXACT" ]

[]

[ "TC:3.A.3", "Wikipedia:P-type_ATPase" ]

[ "GO:0042626" ]

[]

[ "GO:0042626" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20529\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21273\" xsd:anyURI" ]

pg

2019-06-25T19:07:46Z

false

true

2

GO:0140359

140,359

ABC-type transporter activity

molecular_function

Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.

[ "PMID:26517899" ]

null

[ "ABC transporter", "ABC-type efflux permease activity", "ABC-type efflux porter activity", "ABC-type transmembrane transporter activity", "ABC-type uptake permease activity", "ATP binding cassette transporter", "ATP-binding cassette (ABC) transporter activity", "ATP-binding cassette transporter" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "Reactome:R-HSA-266070 \"LTC4 is exported from the cytosol by ABCC1\"", "Reactome:R-HSA-429157 \"ABCC4 accumulation of dense granule contents\"", "Reactome:R-HSA-5362459 \"VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol\"", "Reactome:R-HSA-5387389 \"Hh processing variants are ...

[ "GO:0042626" ]

[]

[ "GO:0042626" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20529\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21273\" xsd:anyURI" ]

pg

2019-06-25T19:08:14Z

false

true

7

GO:0140360

140,360

cyclic-GMP-AMP transmembrane transporter activity

molecular_function

Enables the transfer of cyclic-GMP-AMP from one side of a membrane to the other.

[ "PMID:31126740" ]

null

[]

[ "GO:0000295", "GO:0001409", "GO:0005346" ]

[]

[ "GO:0000295", "GO:0001409", "GO:0005346" ]

[]

pg

2019-07-02T14:49:32Z

false

true

5

GO:0140361

140,361

cyclic-GMP-AMP transmembrane import across plasma membrane

biological_process

The directed movement of cyclic-GMP-AMP from outside of a cell, across the plasma membrane and into the cytosol.

[ "PMID:31126740" ]

null

[]

[ "GO:0015711", "GO:0015868", "GO:0051503", "GO:0070729", "GO:0098739", "GO:1903790" ]

[]

[ "GO:0015711", "GO:0015868", "GO:0051503", "GO:0070729", "GO:0098739", "GO:1903790" ]

[]

pg

2019-07-02T15:49:24Z

false

true

7

GO:0140363

140,363

TIS granule

cellular_component

A ribonucleoprotein granule located in the cytoplasm that is formed by the RNA-binding protein TIS11B and RNA molecules, enriched in membrane protein-encoding mRNAs with multiple AU-rich elements. TIS granules are reticular meshworks intertwined with the endoplasmic reticulum (ER).

[ "PMID:30449617", "PMID:30479375", "Wikipedia:TIGER_domain" ]

null

[]

[ "GO:0036464" ]

[]

[ "GO:0036464" ]

[]

pg

2019-07-25T19:20:58Z

false

true

8

GO:0140364

140,364

GW body

cellular_component

A ribonucleoprotein granule located in the cytoplasm and the nucleus. GW-bodies minimally contain the Argonaute2 (Ago2) and TNRC6B proteins, together with specific target RNAs.

[ "PMID:16418578", "PMID:26930655", "PMID:29576456" ]

null

[ "GW-body" ]

[ "EXACT" ]

[]

[ "GO:0035770" ]

[]

[ "GO:0035770" ]

[]

pg

2019-07-25T19:26:48Z

false

true

3

GO:0140366

140,366

galectin lattice

cellular_component

A non-stoichiometric protein complex formed by several galectins crosslinking glycosylated ligands to form a dynamic lattice. The galectin lattice modulates receptor kinase signaling and the functionality of membrane receptors, by regulating the diffusion, compartmentalization and endocytosis of plasma membrane glycopr...

[ "PMID:19021578", "PMID:26092931", "PMID:28893908", "PMID:30951647" ]

null

[]

[ "GO:0098635" ]

[]

[ "GO:0098635" ]

[]

pg

2019-07-25T19:35:05Z

false

true

7

GO:0140367

140,367

antibacterial innate immune response

biological_process

An defense response against a bacteria mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.

[ "PMID:16177355", "PMID:23006328" ]

null

[]

[ "GO:0042742", "GO:0045087" ]

[]

[ "GO:0042742", "GO:0045087" ]

[]

pg

2019-09-09T11:02:47Z

false

true

9

GO:0140368

140,368

decoy receptor complex

cellular_component

A receptor complex that recognizes, binds and sequesters a specific receptor ligand to prevent it from binding to its regular receptor. May be soluble or membrane bound.

[ "GOC:bhm", "PMID:30621730", "PMID:9168977" ]

null

[ "osteoclastogenesis inhibitory factor", "osteoprotegerin complex" ]

[ "NARROW", "NARROW" ]

[]

[ "GO:0043235" ]

[]

[ "GO:0043235" ]

[]

pg

2019-09-13T16:39:24Z

false

true

3

GO:0140369

140,369

dbTF DNA binding stabilizer activity

molecular_function

A protein binding activity that stimulates and stabilizes the binding of a DNA binding transcription factor to its genomic DNA target, without directly interacting with DNA itself.

[ "PMID:40608935" ]

Note that this is different from a co-regulator activity (GO:0003712) which acts after DNA binding.

[ "DNA binding transcription factorDNA binding stabilizer activity" ]

[ "EXACT" ]

[]

[ "GO:0060090" ]

[]

[ "GO:0060090" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31054\" xsd:anyURI" ]

pg

2026-01-12T08:09:23Z

false

true

2

GO:0140370

140,370

type II oncostatin-M receptor complex

cellular_component

A heterodimeric receptor for the cytokine LIF (leukemia inhibitory factor). In humans the receptor complex is made up of the gene products gp130 and LIFR.

[ "PMID:36930708", "PMID:39532904", "PMID:7738033" ]

null

[ "leukemia inhibitory factor receptor complex", "oncostatin-M receptor complex" ]

[ "EXACT", "BROAD" ]

[]

[ "GO:0098802" ]

[]

[ "GO:0098802" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31369\" xsd:anyURI" ]

pg

2026-01-20T07:37:34Z

false

true

4

GO:0140371

140,371

ornithine lipid biosynthetic process

biological_process

The chemical reactions and pathways resulting in the formation of ornithine lipids, any of a class of phosphorus-free bacterial membrane lipids with an L-ornithine-derived head group.

[ "PMID:22724388" ]

null

[]

[ "MetaCyc:PWY-6818" ]

[ "GO:0008652" ]

[]

[ "GO:0008652" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31271\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31510\" xsd:anyURI" ]

pg

2026-01-20T12:30:41Z

false

true

2

GO:0140373

140,373

obsolete histone H3-K14 ubiquitination

biological_process

OBSOLETE. The modification of histone H3 by the addition of one or more ubiquitin groups to a lysine residue at position 14 of the histone.

[ "GOC:mah", "PMID:31468675" ]

This term was obsoleted because it represents a molecular function.

[ "histone H3 ubiquitination at K14", "histone H3-K14 ubiquitylation", "histone H3K14 ubiquitination" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0140851" ]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24261\" xsd:anyURI" ]

pg

2019-10-03T15:31:15Z

true

7

GO:0140374

140,374

antiviral innate immune response

biological_process

A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.

[ "PMID:31006531" ]

null

[]

[ "GO:0045087", "GO:0051607" ]

[]

[ "GO:0045087", "GO:0051607" ]

[]

pg

2019-10-10T16:41:12Z

false

true

2

GO:0140375

140,375

immune receptor activity

molecular_function

Receiving a signal and transmitting it in a cell to initiate an immune response.

[ "PMID:31415752", "Wikipedia:Immune_receptor" ]

null

[]

[ "GO:0038023" ]

[]

[ "GO:0038023" ]

[]

pg

2019-10-18T14:11:15Z

false

true

8

GO:0140376

140,376

innate immune receptor activity

molecular_function

Receiving a signal and transmitting it in a cell to initiate an innate immune response.

[ "PMID:28921463", "PMID:31415752" ]

null

[]

[ "GO:0140375" ]

[]

[ "GO:0140375" ]

[]

pg

2019-10-18T14:21:28Z

false

true

9

GO:0140377

140,377

sophorolipid biosynthetic process

biological_process

The chemical reactions and pathways resulting in the formation of sophorolipid, a class of glycolipids containing a 2-O-beta-D-glucopyranosyl-D-glucopyranose (sophorose) unit covalently linked to the hydroxyl of a omega-hydroxy long chain fatty acids or (omega-1)-hydroxy long chain fatty acids.

[ "PMID:23516968", "PMID:27251547", "PMID:27317616", "PMID:38937850", "PMID:39143561" ]

null

[]

[ "GO:0009247" ]

[]

[ "GO:0009247" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31362\" xsd:anyURI" ]

pg

2026-01-21T10:01:05Z

false

true

6

GO:0140378

140,378

protein complex scaffold activity

molecular_function

A structural molecule activity of a protein-containing complex component that serves to hold the complex together. Protein complex scaffolds are integral members of complexes.

[ "PMID:41298522" ]

null

[ "protein-complex scaffolding activity", "protein-containing complex scaffold activity" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0005198" ]

[]

[ "GO:0005198" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31444\" xsd:anyURI" ]

pg

2026-02-02T08:05:02Z

false

true

4

GO:0140380

140,380

psilocybin biosynthetic process

biological_process

The chemical reactions and pathways resulting in the formation of psilocybin, a psychotropic tryptamine-derived natural product.

[ "MetaCyc:PWY-7936", "PMID:28763571" ]

null

[]

[ "MetaCyc:PWY-7936" ]

[ "GO:0006568", "GO:0006796", "GO:0035835", "GO:0042435", "GO:0043386", "GO:0090407" ]

[ "has_part GO:0036469", "has_part GO:0140381", "has_part GO:0140382", "has_part GO:0140383" ]

[ "has_part", "has_part", "has_part", "has_part" ]

[ "GO:0036469", "GO:0140381", "GO:0140382", "GO:0140383" ]

[ "GO:0006568", "GO:0006796", "GO:0035835", "GO:0036469", "GO:0042435", "GO:0043386", "GO:0090407", "GO:0140381", "GO:0140382", "GO:0140383" ]

[]

[ "skos:exactMatch MetaCyc:PWY-7936", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23954\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31028\" xsd:anyURI" ]

pg

2019-11-20T10:03:05Z

false

true

2

GO:0140381

140,381

4-hydroxytryptamine 4-phosphate methyltransferase activity

molecular_function

Catalysis of the reaction: 2 S-adenosyl-L-methionine (SAM) + 4-hydroxytryptamine 4-phosphate (norbaeocystin) = 2 S-adenosyl-L-homocysteine + psilocybin.

[ "PMID:28763571" ]

null

[ "norbaeocystin methyltransferase", "psilocybin synthase" ]

[ "EXACT", "EXACT" ]

[]

[ "EC:2.1.1.345", "RHEA:55568" ]

[ "GO:0008168" ]

[]

[ "GO:0008168" ]

[]

[ "skos:exactMatch EC:2.1.1.345", "skos:exactMatch RHEA:55568", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

pg

2019-11-20T10:16:28Z

false

true

9

GO:0140382

140,382

tryptamine 4-monooxygenase activity

molecular_function

Catalysis of the reaction: tryptamine + reduced acceptor + O2 = 4-hydroxytryptamine + acceptor + H2O.

[ "PMID:28763571" ]

null

[]

[ "EC:1.14.99.59", "RHEA:15865" ]

[ "GO:0004497" ]

[]

[ "GO:0004497" ]

[]

[ "skos:exactMatch EC:1.14.99.59", "skos:exactMatch RHEA:15865", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

pg

2019-11-20T10:26:21Z

false

true

1

GO:0140383

140,383

4-hydroxytryptamine kinase activity

molecular_function

Catalysis of the reaction: 4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H+.

[ "PMID:28763571" ]

null

[]

[ "EC:2.7.1.222", "RHEA:55564" ]

[ "GO:0016301" ]

[]

[ "GO:0016301" ]

[]

[ "skos:exactMatch EC:2.7.1.222", "skos:exactMatch RHEA:55564", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

pg

2019-11-20T10:30:05Z

false

true

6

GO:0140384

140,384

metacyclogenesis

biological_process

The morphological, biochemical and genetic changes that induce the differentiation of non-pathogenic parasites into pathogenic metacyclic parasites in the Trypanosomatidae species. The pathogenic parasites are known as metacyclic trypomastigotes in Trypanosoma and metacyclic promastigotes in Leishmania.

[ "PMID:12152483", "PMID:21514274", "PMID:2659372", "PMID:29091711", "PMID:29409544" ]

null

[]

[ "GO:0044114" ]

[]

[ "GO:0044114" ]

[]

pg

2019-11-20T13:25:55Z

false

true

6

GO:0140385

140,385

amino acid transaminase activity

molecular_function

Transfer of an amino group from an amino acid to an acceptor, usually a 2-oxo acid.

[ "GOC:curators" ]

null

[]

[ "GO:0008483" ]

[]

[ "GO:0008483" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31140\" xsd:anyURI" ]

pg

2026-02-02T13:30:09Z

false

true

5

GO:0140386

140,386

tRNA (cytidine(4)/adenine(4)-2'-O-ribose)-methyltransferase activity

molecular_function

Catalysis of the reaction: cytidine(4) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA + S-adenosyl-L-homocysteine + H+. Acts on cytidine(4) on tRNAPro and tRNAGly(GCC), and on adenosine(4) in tRNAHis.

[ "EC:2.1.1.225", "PMID:17242307" ]

null

[]

[ "EC:2.1.1.225", "RHEA:32767", "RHEA:43192", "RHEA:43196" ]

[ "GO:0016426", "GO:0016427" ]

[]

[ "GO:0016426", "GO:0016427" ]

[]

[ "skos:exactMatch EC:2.1.1.225", "skos:narrowMatch RHEA:32767", "skos:narrowMatch RHEA:43192", "skos:narrowMatch RHEA:43196", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31521\" xsd:anyURI" ]

pg

2026-02-06T12:44:45Z

false

true

9

GO:0140387

140,387

negative regulation of L-glutamate biosynthetic process

biological_process

Any process that stops, prevents, or reduces the frequency, rate or extent of L-glutamate biosynthetic process.

[ "PMID:16899818", "PMID:29649217" ]

null

[ "negative regulation of glutamate biosynthetic process", "negative regulation of L-glutamate biosynthesis" ]

[ "BROAD", "BROAD" ]

[]

[ "GO:0062014", "GO:2000283" ]

[ "negatively_regulates GO:0097054" ]

[ "negatively_regulates" ]

[ "GO:0097054" ]

[ "GO:0062014", "GO:0097054", "GO:2000283" ]

[ "GO:0065007", "negatively_regulates GO:0097054" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31582\" xsd:anyURI" ]

pg

2026-02-17T08:55:47Z

false

true

7

GO:0140388

140,388

protein translocation chaperone activity

molecular_function

Binding to the exposed unfolded portion of a polypeptide as it emerges from a membrane translocation channel/pore to drive its unidirectional transport across a membrane. Iterative cycles of ATP-dependent binding/rebinding by the chaperone prevents back sliding and drive vectorial transport.

[ "PMID:11733493" ]

null

[ "import motor chaperone activity", "translocation ratchet activity" ]

[ "RELATED", "RELATED" ]

[]

[ "GO:0140597", "GO:0140657" ]

[]

[ "GO:0140597", "GO:0140657" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31580\" xsd:anyURI" ]

pg

2026-02-18T12:58:22Z

false

true

3

GO:0140389

140,389

pattern recognition receptor complex

cellular_component

A signaling receptor complex that combines with a pathogen-associated molecular pattern (PAMP), a structure conserved among pathogenic organisms, to initiate an innate immune response.

[ "PMID:22654057", "PMID:28302675", "PMID:41719893" ]

null

[ "PAMP receptor complex" ]

[ "EXACT" ]

[]

[ "GO:0043235" ]

[]

[ "GO:0043235" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31605\" xsd:anyURI" ]

pg

2026-02-27T15:46:56Z

false

true

5

GO:0140390

140,390

positive regulation of acetyl-CoA biosynthesis

biological_process

Any process that increases the rate, frequency, or extent of acetyl-CoA biosynthetic process.

[ "PMID:41730913" ]

null

[]

[ "GO:0009891", "GO:0045937", "GO:0050812", "GO:0062013" ]

[ "positively_regulates GO:0006085" ]

[ "positively_regulates" ]

[ "GO:0006085" ]

[ "GO:0006085", "GO:0009891", "GO:0045937", "GO:0050812", "GO:0062013" ]

[ "GO:0065007", "positively_regulates GO:0006085" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31614\" xsd:anyURI" ]

pg

2026-03-04T08:21:53Z

false

true

5

GO:0140391

140,391

negative regulation of acetyl-CoA biosynthesis

biological_process

Any process that stops, prevents or reduces the frequency, rate or extent of acetyl-CoA biosynthetic process.

[ "PMID:39019872" ]

null

[]

[ "GO:0009890", "GO:0045934", "GO:0045936", "GO:0050812", "GO:0062014" ]

[ "negatively_regulates GO:0006085" ]

[ "negatively_regulates" ]

[ "GO:0006085" ]

[ "GO:0006085", "GO:0009890", "GO:0045934", "GO:0045936", "GO:0050812", "GO:0062014" ]

[ "GO:0065007", "negatively_regulates GO:0006085" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31614\" xsd:anyURI" ]

pg

2026-03-04T08:22:01Z

false

true

8

GO:0140392

140,392

extracellular protein-containing complex

cellular_component

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together outside a cell.

[ "GOC:curators" ]

null

[ "extracellular protein complex" ]

[ "BROAD" ]

[]

[ "gocheck_do_not_annotate" ]

[]

[ "GO:0032991" ]

[ "part_of GO:0005576" ]

[ "part_of" ]

[ "GO:0005576" ]

[ "GO:0005576", "GO:0032991" ]

[ "GO:0032991", "part_of GO:0005576" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31673\" xsd:anyURI" ]

pg

2020-09-09T05:12:38Z

false

true

7

GO:0140393

140,393

norsolorinic acid ketoreductase activity

molecular_function

Catalysis of the reaction: (1'S)-averantin + NADP+ = norsolorinic acid + NADPH.

[ "PMID:10584035", "PMID:8368836", "RHEA:35447" ]

null

[]

[ "EC:1.1.1.349", "KEGG_REACTION:R10309", "MetaCyc:RXN-9480", "RHEA:35447" ]

[ "GO:0045703" ]

[]

[ "GO:0045703" ]

[]

[ "skos:exactMatch EC:1.1.1.349", "skos:exactMatch RHEA:35447", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

pg

2019-11-28T14:38:12Z

false

true

9

GO:0140394

140,394

ABC-type azole transporter activity

molecular_function

Enables the transfer of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other according to the reaction: ATP + H2O + azole(in) = ADP + phosphate + azole(out).

[ "PMID:31501141", "RHEA:33503" ]

null

[ "ATPase-coupled azole transmembrane transporter activity", "azole ABC transporter activity" ]

[ "RELATED", "EXACT" ]

[]

[ "RHEA:33503" ]

[ "GO:0140359", "GO:1901474" ]

[]

[ "GO:0140359", "GO:1901474" ]

[]

[ "skos:exactMatch RHEA:33503", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

pg

2019-11-28T18:29:48Z

false

true

7

GO:0140395

140,395

averantin hydroxylase activity

molecular_function

Catalyzes the reaction: (1'S)-averantin + [reduced NADPH--hemoprotein reductase] + O2 = (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH--hemoprotein reductase] + H2O. Involved in aflatoxin biosynthesis.

[ "EC:1.14.14.116", "PMID:8368836" ]

null

[]

[ "EC:1.14.14.116", "MetaCyc:RXN-9482", "RHEA:35575" ]

[ "GO:0016705" ]

[ "part_of GO:0045122" ]

[ "part_of" ]

[ "GO:0045122" ]

[ "GO:0016705", "GO:0045122" ]

[]

[ "skos:exactMatch EC:1.14.14.116", "skos:exactMatch RHEA:35575", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

pg

2019-11-29T08:48:23Z

false

true

1

GO:0140396

140,396

5'-hydroxyaverantin dehydrogenase activity

molecular_function

Catalyzes the reaction: (1'S,5'S)-hydroxyaverantin + NAD+ = 5'-oxoaverantin + NADH.

[ "EC:1.1.1.352", "PMID:14602595" ]

null

[]

[ "EC:1.1.1.352", "RHEA:35475" ]

[ "GO:0016616" ]

[]

[ "GO:0016616" ]

[]

[ "skos:exactMatch EC:1.1.1.352", "skos:exactMatch RHEA:35475", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

pg

2019-11-29T08:56:49Z

false

true

3

GO:0140397

140,397

versiconal hemiacetal acetate esterase activity

molecular_function

Catalyzes the reactions: versiconal hemiacetal acetate + H2O = versiconal + acetate, as well as versiconol acetate + H2O = versiconol + acetate.

[ "EC:3.1.1.94", "PMID:15006741", "PMID:15932995", "PMID:8368837" ]

null

[]

[ "EC:3.1.1.94", "MetaCyc:RXN-9488", "MetaCyc:RXN-9493", "RHEA:35715", "RHEA:35719" ]

[ "GO:0016788" ]

[]

[ "GO:0016788" ]

[]

[ "skos:exactMatch EC:3.1.1.94", "skos:narrowMatch MetaCyc:RXN-9488", "skos:narrowMatch MetaCyc:RXN-9493", "skos:narrowMatch RHEA:35715", "skos:narrowMatch RHEA:35719", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28526\" xsd:anyURI" ]

pg

2019-11-29T10:14:17Z

false

true

9

GO:0140398

140,398

versicolorin B desaturase activity

molecular_function

Catalyzes the reaction: versicolorin B + NADPH + O2 = versicolorin A + NADP+ + 2 H2O. Uses heme-thiolate as a co-factor. Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.

[ "PMID:15006741", "PMID:8368837" ]

null

[]

[ "EC:1.14.19.n5", "KEGG_REACTION:R10479", "MetaCyc:RXN-9495", "RHEA:35743" ]

[ "GO:0016717" ]

[]

[ "GO:0016717" ]

[]

[ "skos:exactMatch EC:1.14.19.n5", "skos:exactMatch RHEA:35743", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

pg

2019-11-29T10:30:25Z

false

true

6

GO:0140399

140,399

aflatoxin B synthase activity

molecular_function

Catalyzes the reaction: 8-O-methylsterigmatocystin + 2 [reduced NADPH--hemoprotein reductase] + 2 O2 = aflatoxin B + 2 [oxidized NADPH--hemoprotein reductase] + H2O + methanol + CO2. Produces both aflatoxin B(1) and aflatoxin B(2).

[ "EC:1.14.14.117" ]

null

[]

[ "EC:1.14.14.117", "MetaCyc:RXN-9497", "MetaCyc:RXN-9502", "RHEA:35759", "RHEA:35763" ]

[ "GO:0016712" ]

[ "part_of GO:0045122" ]

[ "part_of" ]

[ "GO:0045122" ]

[ "GO:0016712", "GO:0045122" ]

[]

[ "skos:exactMatch EC:1.14.14.117", "skos:narrowMatch MetaCyc:RXN-9497", "skos:narrowMatch MetaCyc:RXN-9502", "skos:narrowMatch RHEA:35759", "skos:narrowMatch RHEA:35763", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28526\" xsd:anyURI" ]

pg

2019-11-29T11:06:07Z

false

true

5

GO:0140400

140,400

embryonic sheath

cellular_component

A specialized, transient apical extracellular matrix (aECM) that overlays the apical surface of the embryonic epidermis in Caenorhabditis elegans. It is secreted just prior to the start of embryonic elongation and acts as a mechanical scaffold to maintain embryonic integrity, distribute actomyosin-dependent stress, and...

[ "PMID:22278925", "PMID:25798732", "PMID:28526752", "PMID:33036165" ]

null

[]

[ "GO:0140047" ]

[]

[ "GO:0140047" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31680\" xsd:anyURI" ]

pg

2026-03-06T09:07:34Z

false

true

6

GO:0140403

140,403

effector-mediated suppression of host innate immune response

biological_process

A process mediated by a molecule secreted by a symbiont that results in the suppression of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.

[ "PMID:21467214", "PMID:30584105" ]

null

[ "effector dependent suppression of host immune innate response by symbiont", "effector triggered suppression of host immune innate response by symbiont", "effector-dependent suppression of host immune innate response by symbiont", "effector-mediated suppression of host immune innate response by symbiont", "...

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0052170", "GO:0140404", "GO:0140590" ]

[]

[ "GO:0052170", "GO:0140404", "GO:0140590" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28790\" xsd:anyURI" ]

pg

2019-12-05T11:34:55Z

false

true

2

GO:0140404

140,404

effector-mediated perturbation of host innate immune response by symbiont

biological_process

A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.

[ "PMID:21467214" ]

null

[ "effector mediated modulation of host immune response by symbiont", "effector triggered modulation of host immune response by symbiont", "effector-dependent modulation of host immune response by symbiont", "effector-mediated modulation of host immunity", "effector-mediated modulation of host innate immune r...

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0052167", "GO:0140415" ]

[]

[ "GO:0052167", "GO:0140415" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25569\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28790\" xsd:anyURI" ]

pg

2019-12-05T11:38:44Z

false

true

9

GO:0140405

140,405

spindle pole body-led chromosome movement during mitotic interphase

biological_process

A microtubule-based process in which chromosomes migrate as a result of rapid spindle pole body (SPB) and centrosome oscillations during mitotic interphase.

[ "PMID:31483748" ]

null

[]

[ "GO:0007018", "GO:0050000" ]

[ "happens_during GO:0051329" ]

[ "happens_during" ]

[ "GO:0051329" ]

[ "GO:0007018", "GO:0050000", "GO:0051329" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18373\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19149\" xsd:anyURI" ]

pg

2019-12-10T09:13:47Z

false

true

7

GO:0140406

140,406

L-alanine export across the plasma membrane

biological_process

The directed movement of L-alanine from inside of a cell, across the plasma membrane and into the extracellular region.

[ "PMID:26073055", "PMID:31591285" ]

null

[]

[ "GO:0032973", "GO:1904557" ]

[]

[ "GO:0032973", "GO:1904557" ]

[]

pg

2019-12-11T14:13:07Z

false

true

6

GO:0140407

140,407

L-alanine:proton antiporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out).

[ "PMID:26073055", "PMID:31591285" ]

null

[]

[ "GO:0015078", "GO:0015180", "GO:0140848" ]

[]

[ "GO:0015078", "GO:0015180", "GO:0140848" ]

[]

pg

2019-12-11T14:17:48Z

false

true

1

GO:0140408

140,408

regulation of mRNA alternative polyadenylation

biological_process

Any process that modulates the frequency, rate or extent of mRNA alternative polyadenylation.

[ "PMID:29507755" ]

null

[]

[ "GO:0031440" ]

[ "regulates GO:0110104" ]

[ "regulates" ]

[ "GO:0110104" ]

[ "GO:0031440", "GO:0110104" ]

[ "GO:0065007", "regulates GO:0110104" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15389\" xsd:anyURI" ]

pg

2019-12-13T12:48:14Z

false

true

9

GO:0140410

140,410

monoatomic cation:bicarbonate symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in).

[ "PMID:27166256" ]

null

[ "monoatomic cation:hydrogencarbonate symporter activity", "solute:bicarbonate symporter activity" ]

[ "EXACT", "BROAD" ]

[]

[ "GO:0015106", "GO:0015294" ]

[]

[ "GO:0015106", "GO:0015294" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18345\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26780\" xsd:anyURI" ]

pg

2020-01-07T16:58:49Z

false

true

1

GO:0140412

140,412

zinc:bicarbonate symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) = zinc(in) + HCO3-(in).

[ "PMID:27166256" ]

null

[ "zinc:hydrogencarbonate symporter activity" ]

[ "EXACT" ]

[]

[ "GO:0005385", "GO:0140410" ]

[]

[ "GO:0005385", "GO:0140410" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18345\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26780\" xsd:anyURI" ]

pg

2020-01-07T18:43:02Z

false

true

4

GO:0140413

140,413

zinc:bicarbonate:selenite symporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) + HO3Se-(out) = zinc(in) + HCO3-(in) + HO3Se-(out).

[ "PMID:27166256" ]

null

[ "zinc:hydrogencarbonate:selenate symporter activity" ]

[ "EXACT" ]

[]

[ "GO:0140412" ]

[]

[ "GO:0140412" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18345\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26780\" xsd:anyURI" ]

pg

2020-01-07T18:58:12Z

false

true

7

GO:0140414

140,414

phosphopantetheine-dependent carrier activity

molecular_function

Binding a substrate via a thioester at the terminal thiol of a covalentely linked phosphopantetheine prosthetic group and mediating protein-protein interactions with cognate enzymes for processing or offloading of the thiol-bound substrate.

[ "PMID:17502372" ]

null

[ "carrier protein activity" ]

[ "EXACT" ]

[]

[ "GO:0140104" ]

[]

[ "GO:0140104" ]

[]

pg

2020-01-14T16:15:04Z

false

true

3

GO:0140415

140,415

effector-mediated perturbation of host defenses by symbiont

biological_process

A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction.

[ "PMID:30610168" ]

null

[ "effector-mediated modulation of host defenses by symbiont" ]

[ "EXACT" ]

[]

[ "GO:0052031", "GO:0052200", "GO:0140418" ]

[]

[ "GO:0052031", "GO:0052200", "GO:0140418" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28790\" xsd:anyURI" ]

pg

2020-01-20T16:46:41Z

false

true

2

GO:0140416

140,416

transcription regulator inhibitor activity

molecular_function

A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification.

[ "PMID:10652346" ]

Usage guidance: transcription regulator inhibitors bind to a transcription regulator to prevent it from reaching the chromatin. This activity does not occur at the promoter. For activities that do occur at the promoter, consider GO:0001217 ; DNA-binding transcription repressor activity or GO:0003714 ; transcription cor...

[ "DNA-binding transcription factor inhibitor activity" ]

[ "NARROW" ]

[]

[ "GO:0140678" ]

[ "negatively_regulates GO:0140110", "part_of GO:0010468" ]

[ "negatively_regulates", "part_of" ]

[ "GO:0140110", "GO:0010468" ]

[ "GO:0010468", "GO:0140110", "GO:0140678" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/16132\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18596\" xsd:anyURI" ]

pg

2020-01-21T14:17:39Z

false

true

9

GO:0140417

140,417

intracellularly ATP-gated calcium channel activity

molecular_function

Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a ATP has been bound by the channel complex or one of its constituent parts.

[ "PMID:22736763" ]

null

[ "ATP-sensitive calcium-release channel activity" ]

[ "RELATED" ]

[]

[ "GO:0015278" ]

[]

[ "GO:0015278" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18649\" xsd:anyURI" ]

pg

2020-01-27T09:22:04Z

false

true

6

GO:0140418

140,418

effector-mediated perturbation of host process by symbiont

biological_process

A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host structure or process. The host is defined as the larger of the organisms involved in a symbiotic interaction.

[ "PMID:21467214" ]

null

[ "effector mediated modulation of host process by symbiont", "effector triggered modulation of host process by symbiont", "effector-dependent modulation of host process by symbiont", "effector-mediated modulation of host process by symbiont" ]

[ "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0044003" ]

[]

[ "GO:0044003" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18605\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20971\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28790\" xsd:anyURI" ]

pg

2020-01-29T21:24:42Z

false

true

2

GO:0140421

140,421

endocytic heme import into cell

biological_process

The directed movement into cell of externally available heme by receptor-mediated endocytosis.

[ "PMID:28193844" ]

null

[ "heme assimilation" ]

[ "BROAD" ]

[]

[ "GO:0140298", "GO:0140420" ]

[]

[ "GO:0140298", "GO:0140420" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18671\" xsd:anyURI" ]

pg

2020-01-30T13:14:02Z

false

true

8

GO:0140423

140,423

effector-mediated suppression of host pattern-triggered immunity signaling

biological_process

A process mediated by a molecule secreted by a symbiont that results in the suppression of a pattern-triggered immunity PTI signaling pathway. PTI signaling pathways are found in plants.

[ "PMID:30584105" ]

null

[ "effector-mediated suppression of host pattern recognition receptor signaling", "effector-mediated suppression of host PRR signaling", "effector-mediated suppression of host PRR signalling", "effector-mediated suppression of pattern-triggered immunity signaling", "effector-mediated suppression of PTI signal...

[ "BROAD", "BROAD", "BROAD", "EXACT", "EXACT" ]

[]

[ "GO:0052034" ]

[]

[ "GO:0052034" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18683\" xsd:anyURI" ]

pg

2020-02-03T09:50:33Z

false

true

2

GO:0140425

140,425

galactose import across plasma membrane

biological_process

The directed movement of galactose from outside of a cell, across the plasma membrane and into the cytosol.

[ "PMID:21621292", "PMID:23254763" ]

null

[]

[ "GO:0015757", "GO:0140271" ]

[]

[ "GO:0015757", "GO:0140271" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18788\" xsd:anyURI" ]

pg

2020-02-10T08:46:09Z

false

true

6

GO:0140426

140,426

pathogen-associated molecular pattern receptor signaling pathway

biological_process

The series of molecular signals initiated by a ligand binding of a pattern recognition receptor (PRR) to activate a plant innate immune response. PAMP-triggered immunity PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.

[ "PMID:25744358" ]

null

[ "MAMP-triggered immunity signalling", "PAMP receptor signaling pathway", "PAMP-triggered immunity signalling pathway", "pathogen-associated molecular pattern signalling", "PTI signalling" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0002221" ]

[]

[ "GO:0002221" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18588\" xsd:anyURI" ]

pg

2020-02-11T11:08:57Z

false

true

3

GO:0140429

140,429

positive regulation of mitotic sister chromatid biorientation

biological_process

Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid biorientation, the mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can procee...

[ "GOC:mtg_cell_cycle", "GOC:vw", "PMID:15525536", "PMID:20739936", "PMID:21306900" ]

null

[ "correction of merotelic kinetochore attachment, mitotic", "correction of mono-orientation defects", "correction of syntelic kinetochore attachment, mitotic", "repair of mitotic merotelic kinetochore attachment defect", "repair of mitotic merotelic kinetochore attachment defects", "repair of mitotic mono-...

[ "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW" ]

[ "GO:0098783", "GO:1990598" ]

[]

[ "GO:0072479", "GO:0140273", "GO:1902425" ]

[ "positively_regulates GO:1990758" ]

[ "positively_regulates" ]

[ "GO:1990758" ]

[ "GO:0072479", "GO:0140273", "GO:1902425", "GO:1990758" ]

[ "GO:0065007", "positively_regulates GO:1990758" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18815\" xsd:anyURI" ]

jl

2015-01-05T16:54:39Z

false

true

9

GO:0140430

140,430

positive regulation of chromosome passenger complex localization to kinetochore

biological_process

Any process that activates or increases the frequency, rate or extent of a chromosome passenger complex localization to kinetochore.

[ "PMID:20739936" ]

null

[]

[ "GO:1905342" ]

[ "positively_regulates GO:0072356" ]

[ "positively_regulates" ]

[ "GO:0072356" ]

[ "GO:0072356", "GO:1905342" ]

[ "GO:0065007", "positively_regulates GO:0072356" ]

[]

pg

2020-02-19T05:19:45Z

false

true

3

GO:0140431

140,431

DNA-(abasic site) binding

molecular_function

Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base.

[ "PMID:23245849" ]

null

[ "DNA AP site binding", "DNA-(apurinic site) binding", "DNA-(apurinic site/apyrimidinic site) binding", "DNA-(apyrimidinic site) binding" ]

[ "EXACT", "NARROW", "EXACT", "NARROW" ]

[]

[ "GO:0003684" ]

[]

[ "GO:0003684" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18878\" xsd:anyURI" ]

pg

2020-02-19T05:30:09Z

false

true

4

GO:0140433

140,433

regulation of protein localization to meiotic spindle pole body

biological_process

Any process that modulates the frequency, rate or extent of protein localization to a meiotic spindle pole body.

[ "PMID:22438582" ]

null

[]

[ "GO:1902363" ]

[ "regulates GO:1902441" ]

[ "regulates" ]

[ "GO:1902441" ]

[ "GO:1902363", "GO:1902441" ]

[ "GO:0065007", "regulates GO:1902441" ]

[]

pg

2020-02-24T13:26:53Z

false

true

2

GO:0140434

140,434

positive regulation of protein localization to meiotic spindle pole body

biological_process

Any process that increases the frequency, rate or extent of protein localization to a meiotic spindle pole body.

[ "PMID:22438582" ]

null

[]

[ "GO:0140433", "GO:1902365" ]

[ "positively_regulates GO:1902441" ]

[ "positively_regulates" ]

[ "GO:1902441" ]

[ "GO:0140433", "GO:1902365", "GO:1902441" ]

[ "GO:0065007", "positively_regulates GO:1902441" ]

[]

pg

2020-02-24T13:27:01Z

false

true

7

GO:0140438

140,438

protein stearoylation

biological_process

The covalent attachment of a stearoyl group to an amino acid in a protein.

[ "PMID:26214738" ]

null

[]

[ "gocheck_obsoletion_candidate" ]

[]

[ "GO:0006497" ]

[]

[ "GO:0006497" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18882\" xsd:anyURI" ]

pg

2020-03-11T07:54:48Z

false

true

7

GO:0140439

140,439

protein-cysteine S-stearoyltransferase activity

molecular_function

Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-octadecanoyl-L-cysteinyl-[protein].

[ "PMID:12681491", "PMID:22247542", "PMID:22968831", "RHEA:59740" ]

null

[]

[ "RHEA:59740" ]

[ "GO:0019707" ]

[]

[ "GO:0019707" ]

[]

[ "skos:exactMatch RHEA:59740", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18882\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

pg

2020-03-11T09:55:48Z

false

true

2

GO:0140440

140,440

protein-cysteine S-oleoyltransferase activity

molecular_function

Catalysis of the transfer of an oleoyl (systematic name, (9Z)-octadecenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein].

[ "PMID:22247542", "RHEA:59744" ]

null

[]

[ "RHEA:59744" ]

[ "GO:0019707" ]

[]

[ "GO:0019707" ]

[]

[ "skos:exactMatch RHEA:59744", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18882\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

pg

2020-03-11T09:56:11Z

false

true

6

GO:0140443

140,443

mitochondrion-plasma membrane adaptor activity

molecular_function

The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.

[ "PMID:31582398" ]

null

[ "mitochondrion plasma membrane adaptor activity", "mitochondrion plasma membrane tether activity", "plasma membrane-mitochondrion adaptor activity", "plasma membrane-mitochondrion tether activity" ]

[ "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0043495" ]

[]

[ "GO:0043495" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19090\" xsd:anyURI" ]

pg

2020-03-24T13:11:20Z

false

true

3