Datasets:
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GO

Dataset card Data Studio Files
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 Community
go_id
string
go_numeric_id
int64
name
string
namespace
string
definition
string
definition_xrefs
list
comment
string
synonyms
list
synonym_scopes
list
alt_ids
list
subsets
list
xrefs
list
is_a_ids
list
relationship_edges
list
relationship_types
list
relationship_target_ids
list
parent_ids
list
intersection_of
list
union_of
list
disjoint_from
list
replaced_by
list
consider
list
property_values
list
created_by
string
creation_date
string
is_obsolete
bool
in_go_basic
bool
split_bucket
int64
GO:0140587
140,587
chromatin loop anchoring activity
molecular_function
Bridging together two DNA loop anchors together, maintaining a chromatin loop.
[ "PMID:32213323" ]
null
[ "chromosomal loop binding", "DNA loop binding" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0031490", "GO:0106260" ]
[]
[]
[]
[ "GO:0031490", "GO:0106260" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20204\" xsd:anyURI" ]
pg
2021-02-04T14:53:13Z
false
true
5
GO:0140588
140,588
chromatin looping
biological_process
A chromatin organization process that starts with the loading of an extrusion motor (by an SMC family complex) onto the chromatin, followed by chromatin extrusion that stops at loop anchoring sites on the chromosome.
[ "PMID:32213323" ]
To describe the molecular function associated with chromatin looping, consider 'chromatin extrusion motor activity'; GO:0140584.
[ "chromatin folding", "chromatin loop assembly", "DNA loop extrusion", "DNA looping" ]
[ "RELATED", "EXACT", "EXACT", "BROAD" ]
[]
[]
[]
[ "GO:0006325" ]
[]
[]
[]
[ "GO:0006325" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20204\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22109\" xsd:anyURI" ]
pg
2021-02-04T14:55:20Z
false
true
4
GO:0140590
140,590
effector-mediated suppression of host defense response
biological_process
A process mediated by a molecule secreted by a symbiont that results in the suppression of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:28082413" ]
null
[ "effector-mediated suppression of host defenses", "effector-mediated suppression of host defenses by symbiont" ]
[ "RELATED", "EXACT" ]
[]
[]
[]
[ "GO:0140415" ]
[]
[]
[]
[ "GO:0140415" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20813\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28790\" xsd:anyURI" ]
pg
2021-02-08T07:26:05Z
false
true
7
GO:0140591
140,591
nuclear envelope budding
biological_process
The process by which large macromolecular complexes are budded through the inner nuclear membrane, into the perinuclear space, thus acquiring a membrane envelope. The enveloped particle fuses with the outer nuclear membrane and is released into the cytoplasm.
[ "PMID:27236823", "PMID:32503943" ]
null
[]
[]
[]
[]
[]
[ "GO:0051168" ]
[]
[]
[]
[ "GO:0051168" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20782\" xsd:anyURI" ]
pg
2021-02-08T08:31:06Z
false
true
9
GO:0140592
140,592
histone H3R8 methyltransferase activity
molecular_function
Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 8) = S-adenosyl-L-homocysteine + (histone H3-N-methyl-arginine (position 8). This reaction is the addition of a methyl group to the arginine residue at position 8 of histone H3.
[ "PMID:20708585", "PMID:31533925" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3R8 arginine methylase activity", "histone H3R8 arginine methyltransferase activity", "histone methyltransferase activity (H3-R8 specific)", "histone-H3R8 methyltransferase activity" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0016274", "GO:0140938" ]
[]
[]
[]
[ "GO:0016274", "GO:0140938" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.1.1.319", "skos:broadMatch EC:2.1.1.320", "skos:broadMatch RHEA:48108", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20037\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI", "term_tracker_item \"https...
pg
2021-02-09T14:13:17Z
false
true
5
GO:0140593
140,593
host apoplast
cellular_component
The apoplast region surrounding a host plant cell. Plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and so...
[ "PMID:28082413" ]
null
[ "host cell apoplast" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0033643" ]
[]
[]
[]
[ "GO:0033643" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20814\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21343\" xsd:anyURI" ]
pg
2021-02-09T18:56:11Z
false
true
8
GO:0140594
140,594
xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity
molecular_function
Stops, prevents or reduces the activity of xyloglucan-specific endo-beta-1,4-glucanase.
[ "PMID:28082413" ]
null
[]
[]
[]
[]
[]
[ "GO:0004857" ]
[ "negatively_regulates GO:0033946" ]
[ "negatively_regulates" ]
[ "GO:0033946" ]
[ "GO:0004857", "GO:0033946" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20814\" xsd:anyURI" ]
pg
2021-02-09T18:59:49Z
false
true
4
GO:0140595
140,595
MIM complex
cellular_component
A protein complex located in the mitochondrial outer membrane that functions as an insertase, mediating the insertion of alpha-helical proteins from the cytosol into the outer membrane. Client proteins are usually single- and multi-span proteins that include components of the TOM complex.
[ "GOC:vw" ]
null
[ "mitochondrial outer import machinery" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0098799" ]
[]
[]
[]
[ "GO:0098799" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20669\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30352\" xsd:anyURI" ]
pg
2021-02-09T19:34:16Z
false
true
7
GO:0140596
140,596
TOM complex
cellular_component
A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. TOM transports beta-barrel precursors across the outer membrane and the sorting and assembly machinery (SAM complex) inserts them into the target membrane.
[ "PMID:33035511" ]
null
[ "translocase of the outer mitochondrial membrane" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0005742" ]
[]
[]
[]
[ "GO:0005742" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20669\" xsd:anyURI" ]
pg
2021-02-09T19:43:51Z
false
true
8
GO:0140597
140,597
protein carrier activity
molecular_function
Binding to and carrying a protein to an acceptor molecule or to a specific location by moving along with the target protein.
[ "PMID:7628437" ]
null
[ "protein carrier chaperone", "protein chaperone" ]
[ "EXACT", "BROAD" ]
[]
[]
[]
[ "GO:0140104" ]
[]
[]
[]
[ "GO:0140104" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15917\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22127\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22356\" xsd:anyURI", "term_tracker_item \"https://gi...
pg
2021-02-10T06:16:16Z
false
true
6
GO:0140598
140,598
lipoprotein carrier activity
molecular_function
Binding to and carrying a lipoprotein between two different cellular locations by moving along with the target lipoprotein.
[ "PMID:7628437" ]
null
[]
[]
[]
[]
[]
[ "GO:0140597" ]
[]
[]
[]
[ "GO:0140597" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15917\" xsd:anyURI" ]
pg
2021-02-10T06:16:26Z
false
true
5
GO:0140599
140,599
mitotic nuclear bridge midzone membrane domain
cellular_component
A nuclear membrane part at the midzone of the mitotic nuclear bridge. The midzone forms a bulge that is enriched in nuclear pores that lack baskets.
[ "PMID:25963819", "PMID:32502403" ]
null
[]
[]
[]
[]
[]
[ "GO:0110165" ]
[ "part_of GO:0140512" ]
[ "part_of" ]
[ "GO:0140512" ]
[ "GO:0110165", "GO:0140512" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20526\" xsd:anyURI" ]
pg
2021-02-10T13:39:43Z
false
true
2
GO:0140602
140,602
nucleolar peripheral inclusion body
cellular_component
Inclusion bodies located at the nucleolar periphery where several nuclear factors are reversibly aggregated and sequestered during acute heat stress or starvation.
[ "PMID:33176152", "PMID:37128864" ]
null
[ "nucleolar rings", "NuRs" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0042405" ]
[]
[]
[]
[ "GO:0042405" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20579\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25511\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29538\" xsd:anyURI" ]
pg
2021-02-12T15:38:17Z
false
true
7
GO:0140604
140,604
mycofactocin biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of the coenzyme mycofactocin, a variably glycosylated small molecule electron pair carrier derived from the C-terminal valine-tyrosine dipeptide of the ribosomally translated precursor peptide MftA.
[ "PMID:21223593", "PMID:27312813", "PMID:30183269", "PMID:30778644", "PMID:31381312", "PMID:33014324" ]
null
[]
[]
[]
[]
[]
[ "GO:0009058" ]
[]
[]
[]
[ "GO:0009058" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20547\" xsd:anyURI" ]
pg
2021-02-16T07:42:51Z
false
true
5
GO:0140605
140,605
proton motive force-driven motor activity
molecular_function
A motor activity driven by an electrochemical proton gradient (proton-motive force). PMF-driven motors are used by bacterial flagella.
[ "PMID:18216858" ]
null
[]
[]
[]
[]
[]
[ "GO:0003774" ]
[]
[]
[]
[ "GO:0003774" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19590\" xsd:anyURI" ]
pg
2021-02-17T08:04:50Z
false
true
1
GO:0140608
140,608
cysteine-type endopeptidase activator activity
molecular_function
Binds to and increases the activity of a cysteine-type endopeptidase.
[ "PMID:32558991" ]
null
[ "caspase activator activator activity" ]
[ "NARROW" ]
[]
[]
[]
[ "GO:0061133" ]
[ "positively_regulates GO:0004197" ]
[ "positively_regulates" ]
[ "GO:0004197" ]
[ "GO:0004197", "GO:0061133" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20916\" xsd:anyURI" ]
pg
2021-02-18T08:58:58Z
false
true
2
GO:0140609
140,609
phycocyanobilin biosynthetic process
biological_process
The chemical reactions or pathway resulting in the formation of phycocyanobilin, which involves the oxidative cleavage of heme by a heme oxygenase (HO) to form biliverdin IX alpha. Biliverdin IX alpha is subsequently converted to phycocyanobilin by a ferredoxin-dependent oxidoreductase (PCYA).
[ "PMID:23345435" ]
null
[ "phycocyanobilin biosynthesis" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0033014" ]
[]
[]
[]
[ "GO:0033014" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20941\" xsd:anyURI" ]
pg
2021-02-24T10:02:19Z
false
true
9
GO:0140610
140,610
RNA sequestering activity
molecular_function
Binding to a specific RNA molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
[ "PMID:23334420", "PMID:29084823" ]
null
[]
[]
[]
[]
[]
[ "GO:0140313" ]
[ "has_part GO:0003723" ]
[ "has_part" ]
[ "GO:0003723" ]
[ "GO:0003723", "GO:0140313" ]
[ "GO:0140313", "has_part GO:0003723" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20945\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29982\" xsd:anyURI" ]
pg
2021-02-24T13:53:46Z
false
true
5
GO:0140612
140,612
DNA damage sensor activity
molecular_function
A molecule that recognises toxic DNA structures, for example, double-strand breaks or collapsed replication forks, and initiates a signaling response.
[ "PMID:31995034" ]
null
[ "DNA damage sensing activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0140299" ]
[ "has_part GO:0003684" ]
[ "has_part" ]
[ "GO:0003684" ]
[ "GO:0003684", "GO:0140299" ]
[ "GO:0140299", "has_part GO:0003684" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19051\" xsd:anyURI" ]
pg
2021-03-03T18:11:17Z
false
true
7
GO:0140613
140,613
P-type manganese transporter activity
molecular_function
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(in) = ADP + H+ + Mn2+(out) + phosphate.
[ "PMID:11134055", "PMID:15590060", "PMID:15831496", "PMID:21187401", "RHEA:66820" ]
null
[]
[]
[]
[]
[ "MetaCyc:RXN-20940", "RHEA:66820" ]
[ "GO:0005384", "GO:0015662", "GO:0019829" ]
[]
[]
[]
[ "GO:0005384", "GO:0015662", "GO:0019829" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch RHEA:66820", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20918\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26941\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
pg
2021-03-03T22:11:36Z
false
true
6
GO:0140614
140,614
1,8-dihydroxynaphthalene-melanin biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of dihydroxy naphthalene (DHN)-melanin.
[ "PMID:12788746", "PMID:23998343" ]
null
[ "DHN-melanin biosynthesis" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0019290", "GO:0030639", "GO:0042438" ]
[]
[]
[]
[ "GO:0019290", "GO:0030639", "GO:0042438" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20974\" xsd:anyURI" ]
pg
2021-03-04T11:54:05Z
false
true
2
GO:0140615
140,615
ATP-dependent citrate lyase complex
cellular_component
A protein complex that catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA.
[ "PMID:12376641" ]
null
[ "citrate lyase complex", "citrate synthase complex" ]
[ "BROAD", "BROAD" ]
[]
[]
[]
[ "GO:1990234" ]
[]
[]
[]
[ "GO:1990234" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21028\" xsd:anyURI" ]
pg
2021-03-08T14:15:18Z
false
true
9
GO:0140616
140,616
iodotyrosine deiodinase activity
molecular_function
Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH. Note that this activity has only been demonstrated in the direction of 3-deiodination. 3-bromo-L-tyrosine and 3-chloro-L-tyrosine can also be used as substrates.
[ "PMID:15289438", "PMID:18434651", "PMID:25395621", "PMID:27643701", "RHEA:32479" ]
null
[ "iodide peroxidase-tyrosine iodinase activity", "iodotyrosine deiodase activity", "monoiodotyrosine deiodinase activity", "tyrosine iodinase activity" ]
[ "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[ "EC:1.21.1.1", "Reactome:R-HSA-209921 \"Monoiodinated tyrosine can be deiodinated\"", "Reactome:R-HSA-209960 \"Diiodinated tyrosine can be deiodinated\"", "RHEA:32479" ]
[ "GO:0046992" ]
[]
[]
[]
[ "GO:0046992" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.21.1.1", "skos:exactMatch RHEA:32479", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21027\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22877\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontol...
pg
2021-03-08T15:36:42Z
false
true
3
GO:0140617
140,617
obsolete transvection
biological_process
OBSOLETE. An epigenetic regulation of transcription by physical interaction between a cis-acting element (enhancer, silencer) of one allele on one chromosome and the promoter of the corresponding allele on the homologous chromosome. Transvection can lead to either gene activation or repression.
[ "PMID:24236213", "PMID:33479152" ]
This term was obsoleted because it represents an observation, not a GO process.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0040029" ]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21038\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24494\" xsd:anyURI" ]
pg
2021-03-08T18:30:47Z
true
true
5
GO:0140618
140,618
ferric-chelate reductase (NADH) activity
molecular_function
Catalysis of the reaction: 2 a Fe(II)-siderophore + NAD+ + H+ = 2 a Fe(III)-siderophore + NADH.
[ "RHEA:15061" ]
null
[ "ferric chelate reductase activity", "iron chelate reductase activity", "NADH:Fe(3+) oxidoreductase activity", "NADH:Fe3+ oxidoreductase activity" ]
[ "BROAD", "BROAD", "EXACT", "EXACT" ]
[]
[]
[ "EC:1.16.1.7", "MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN", "RHEA:15061" ]
[ "GO:0000293", "GO:0016723" ]
[]
[]
[]
[ "GO:0000293", "GO:0016723" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.16.1.7", "skos:exactMatch RHEA:15061", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21029\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontol...
pg
2021-03-09T07:20:30Z
false
true
2
GO:0140619
140,619
DNA strand exchange activator activity
molecular_function
Binds to and increases a DNA strand exchange activity.
[ "PMID:33493431" ]
null
[]
[]
[]
[]
[]
[ "GO:0008047" ]
[ "positively_regulates GO:0000150" ]
[ "positively_regulates" ]
[ "GO:0000150" ]
[ "GO:0000150", "GO:0008047" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20964\" xsd:anyURI" ]
pg
2021-02-26T17:56:46Z
false
true
5
GO:0140620
140,620
DNA strand exchange inhibitor activity
molecular_function
Binds to and stops, prevents or reduces a DNA strand exchange activity.
[ "PMID:33493431" ]
null
[]
[]
[]
[]
[]
[ "GO:0004857" ]
[ "negatively_regulates GO:0000150" ]
[ "negatively_regulates" ]
[ "GO:0000150" ]
[ "GO:0000150", "GO:0004857" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20964\" xsd:anyURI" ]
pg
2021-02-26T17:57:00Z
false
true
2
GO:0140621
140,621
type I pilus
cellular_component
A short filamentous structure on the surface of a bacterial cell distinguished from other pili by their D-mannose-sensitive agglutinatination of erythrocytes. In E. coli, type I pili consist of a short tip fibrillum made up of the adhesin protein (FimH) and two minor subunits (FimG and FimF) that is joined to the pilus...
[ "PMID:28496159", "PMID:29345620" ]
null
[ "type 1 pilus", "type I fimbriae", "type I pili" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009289" ]
[]
[]
[]
[ "GO:0009289" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14470\" xsd:anyURI" ]
pg
2021-03-10T10:24:04Z
false
true
8
GO:0140622
140,622
ER-to-endosome phospholipid transfer complex
cellular_component
Lipid transfer complex that is responsible for the non-vesicular transport of phospholipids, such as phosphatidylserine, from the endoplasmic reticulum to the endosome. It resides in the endosomal (acceptor) membrane and binds to specific lipids on the donor membrane at the ER-endosome contact site.
[ "GOC:lnp", "PMID:20016005", "PMID:24366873" ]
null
[]
[]
[]
[]
[]
[ "GO:0098796" ]
[ "part_of GO:0010008" ]
[ "part_of" ]
[ "GO:0010008" ]
[ "GO:0010008", "GO:0098796" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15338\" xsd:anyURI" ]
pg
2021-03-10T11:27:24Z
false
true
1
GO:0140623
140,623
type I pilus assembly
biological_process
The assembly from its constituent parts of a type I pilus.
[ "PMID:1679330" ]
null
[ "T1P assembly", "type 1 pilus biogenesis", "type I fimbria assembly", "type I fimbria biogenesis", "type I fimbriae assembly", "type I fimbriae biogenesis", "type I fimbrial assembly", "type I fimbrial biogenesis", "type I fimbrium assembly", "type I fimbrium biogenesis" ]
[ "BROAD", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009297" ]
[]
[]
[]
[ "GO:0009297" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14469\" xsd:anyURI" ]
pg
2021-03-10T12:23:20Z
false
true
5
GO:0140626
140,626
opioid growth factor receptor signaling pathway
biological_process
The series of molecular signals generated as a consequence of an opioid growth factor receptor binding to its physiological ligand, opioid growth factor (OGF, met-enkephalin). The OGF-OGFr complex leads to the increase in the synthesis of the selective cyclin-dependent kinase (CDK) inhibitor proteins, p12 (POLD4) and p...
[ "PMID:19675283", "PMID:19923357" ]
Note that this term represents the activation of the zeta-opioid receptor. Do not confuse with GO:0038003 ; G protein-coupled opioid receptor signaling pathway, activated by the delta, kappa, mu, and nociceptin opioid receptors.
[]
[]
[]
[]
[ "Wikipedia:OGFr", "Wikipedia:Opioid_receptor" ]
[ "GO:0007165" ]
[ "has_part GO:0140625" ]
[ "has_part" ]
[ "GO:0140625" ]
[ "GO:0007165", "GO:0140625" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21110\" xsd:anyURI" ]
pg
2021-03-18T08:30:43Z
false
true
1
GO:0140627
140,627
ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
biological_process
The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the s...
[ "PMID:29775578", "PMID:29779948" ]
null
[ "DesCEND" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0043161" ]
[]
[]
[]
[ "GO:0043161" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21184\" xsd:anyURI" ]
pg
2021-03-24T07:30:47Z
false
true
5
GO:0140628
140,628
outward rectifier potassium channel inhibitor activity
molecular_function
Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel.
[ "PMID:28108814" ]
null
[]
[]
[]
[]
[]
[ "GO:0019870" ]
[ "negatively_regulates GO:0015271" ]
[ "negatively_regulates" ]
[ "GO:0015271" ]
[ "GO:0015271", "GO:0019870" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21157\" xsd:anyURI" ]
pg
2021-03-24T07:58:39Z
false
true
6
GO:0140629
140,629
small conductance calcium-activated potassium channel inhibitor activity
molecular_function
Binds to and stops, prevents, or reduces the activity of a small conductance calcium-activated potassium channel.
[ "PMID:20562108" ]
null
[]
[]
[]
[]
[]
[ "GO:0019870" ]
[ "negatively_regulates GO:0016286" ]
[ "negatively_regulates" ]
[ "GO:0016286" ]
[ "GO:0016286", "GO:0019870" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21175\" xsd:anyURI" ]
pg
2021-03-25T09:53:57Z
false
true
4
GO:0140630
140,630
all-trans-phytoene synthase activity
molecular_function
Catalysis of the reaction: 2 geranylgeranyl diphosphate = all-trans-phytoene + 2 diphosphate.
[ "PMID:12641468", "PMID:7896759" ]
null
[ "phytoene synthase activity" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0016462" ]
[ "part_of GO:0016117" ]
[ "part_of" ]
[ "GO:0016117" ]
[ "GO:0016117", "GO:0016462" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21165\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30815\" xsd:anyURI" ]
pg
2021-03-25T18:04:01Z
false
true
4
GO:0140631
140,631
aldehyde dehydrogenase (NAD+) inhibitor activity
molecular_function
Binds to and stops, prevents or reduces the activity of aldehyde dehydrogenase (NAD+).
[ "PMID:33495566" ]
null
[]
[]
[]
[]
[]
[ "GO:0004857" ]
[ "negatively_regulates GO:0004029" ]
[ "negatively_regulates" ]
[ "GO:0004029" ]
[ "GO:0004029", "GO:0004857" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21265\" xsd:anyURI" ]
pg
2021-04-09T09:40:21Z
false
true
4
GO:0140632
140,632
canonical inflammasome complex assembly
biological_process
The aggregation, arrangement and bonding together of a set of components to form an inflammasome complex.
[ "PMID:33420028", "PMID:33420033", "PMID:33542150" ]
null
[]
[]
[]
[]
[]
[ "GO:0065003" ]
[ "part_of GO:0141084" ]
[ "part_of" ]
[ "GO:0141084" ]
[ "GO:0065003", "GO:0141084" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21092\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24798\" xsd:anyURI" ]
pg
2021-04-09T11:11:41Z
false
true
5
GO:0140633
140,633
CARD8 inflammasome complex assembly
biological_process
The aggregation, arrangement and bonding together of a set of components to form a CARD8 inflammasome complex.
[ "PMID:33420028", "PMID:33420033", "PMID:33542150" ]
null
[]
[]
[]
[]
[]
[ "GO:0140632" ]
[]
[]
[]
[ "GO:0140632" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21092\" xsd:anyURI" ]
pg
2021-04-09T11:19:51Z
false
true
1
GO:0140634
140,634
CARD8 inflammasome complex
cellular_component
An inflammasome complex that consists of CARD8 and CASP1.
[ "PMID:33420028", "PMID:33420033", "PMID:33542150" ]
null
[]
[]
[]
[]
[]
[ "GO:0061702" ]
[]
[]
[]
[ "GO:0061702" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21092\" xsd:anyURI" ]
pg
2021-04-09T11:24:48Z
false
true
7
GO:0140635
140,635
neutrophil dispersal
biological_process
The movement of a neutrophil away from the site of wound or infection following its initial migration to the site.
[ "PMID:31727891" ]
null
[]
[]
[]
[]
[]
[ "GO:1990266" ]
[]
[]
[]
[ "GO:1990266" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21081\" xsd:anyURI" ]
pg
2021-04-13T07:06:25Z
false
true
7
GO:0140638
140,638
small ribosomal subunit processing complex
cellular_component
A small heterodimeric protein complex that is required during early maturation of nascent 40S ribosomal subunits. The complex has endonuclease activity, it interacts with the small ribosomal subunit pre-rRNA and cleave it it to produce the mature 18S (or small ribosomal subunit) rRNA. In S. cerevisiae it is composed of...
[ "GOC:lnp", "PMID:21849504", "PMID:25064857" ]
null
[ "small ribosomal subunit maturation complex" ]
[ "RELATED" ]
[]
[]
[]
[ "GO:1902555" ]
[]
[]
[]
[ "GO:1902555" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15290\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23218\" xsd:anyURI" ]
pg
2021-04-21T08:07:11Z
false
true
2
GO:0140641
140,641
mitotic spindle formation (spindle phase two)
biological_process
The spindle organization process in which the spindle is maintained at a constant length during mitotic metaphase.
[ "PMID:32723864" ]
null
[ "metaphase spindle stability", "metaphase spindle stabilization" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0090307" ]
[]
[]
[]
[ "GO:0090307" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21349\" xsd:anyURI" ]
pg
2021-05-11T08:15:15Z
false
true
7
GO:0140642
140,642
meiotic spindle formation (spindle phase two)
biological_process
The spindle organization process in which the spindle is maintained at a constant length during meiotic metaphase.
[ "PMID:32723864" ]
null
[]
[]
[]
[]
[]
[ "GO:0090306" ]
[]
[]
[]
[ "GO:0090306" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21349\" xsd:anyURI" ]
pg
2021-05-11T08:18:16Z
false
true
4
GO:0140643
140,643
hydroxymethylglutaryl-CoA reductase (NADH) activity
molecular_function
Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH.
[ "PMID:29224355", "RHEA:14833" ]
Note that this activity is not present in eukaryotes, see PMID:29224355.
[ "3-hydroxy-3-methylglutaryl coenzyme A reductase activity", "beta-hydroxy-beta-methylglutaryl CoA-reductase activity", "beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity", "HMG-CoA reductase activity", "hydroxymethylglutaryl coenzyme A reductase activity" ]
[ "BROAD", "BROAD", "BROAD", "BROAD", "BROAD" ]
[]
[]
[ "EC:1.1.1.88", "KEGG_REACTION:R02081", "MetaCyc:HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN", "RHEA:14833" ]
[ "GO:0016616" ]
[]
[]
[]
[ "GO:0016616" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.1.1.88", "skos:exactMatch RHEA:14833", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21411\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
pg
2021-05-11T16:00:35Z
false
true
6
GO:0140644
140,644
neutrophil extracellular trap
cellular_component
Extracellular microbicidal structure composed of nuclear chromatin, histones and granular antimicrobial proteins. Histones and several neutrophil granule proteins associated with the DNA framework damage entrapped microorganisms.
[ "PMID:31172493" ]
null
[ "NET" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0043264" ]
[]
[]
[]
[ "GO:0043264" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21416\" xsd:anyURI" ]
pg
2021-05-12T07:03:05Z
false
true
8
GO:0140645
140,645
neutrophil extracellular trap formation
biological_process
The aggregation, arrangement and bonding together of a set of components to form a neutrophil extracellular trap, a network of extracellular fibers primarily composed of DNA from neutrophils, which bind and neutralizes pathogens.
[ "PMID:28267716" ]
null
[ "NET formation" ]
[ "BROAD" ]
[]
[]
[ "http://purl.obolibrary.org/obo/TXPO_0002149" ]
[ "GO:0022607" ]
[]
[]
[]
[ "GO:0022607" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21416\" xsd:anyURI" ]
pg
2021-05-12T07:08:07Z
false
true
9
GO:0140647
140,647
P450-containing electron transport chain
biological_process
A electron transport chain in which one or more electron carriers operate to transfer electrons from donors to a cytochrome P450 protein or domain. Electron carriers operating in this chain include FAD-containing flavoproteins or domains, FMN domains, ferredoxins and cytochrome b5. The reduced cytochrome P450 functions...
[ "PMID:16042601" ]
null
[ "P450-containing system" ]
[ "RELATED" ]
[]
[]
[ "Wikipedia:P450-containing_systems" ]
[ "GO:0022900" ]
[]
[]
[]
[ "GO:0022900" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21455\" xsd:anyURI" ]
pg
2021-05-21T08:34:01Z
false
true
9
GO:0140648
140,648
positive regulation of cell cycle switching, mitotic to meiotic cell cycle
biological_process
Any process that activates or increases the frequency, rate or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division.
[ "PMID:22375066" ]
null
[]
[]
[]
[]
[]
[ "GO:0051446", "GO:0090068", "GO:0110044" ]
[ "positively_regulates GO:0051728" ]
[ "positively_regulates" ]
[ "GO:0051728" ]
[ "GO:0051446", "GO:0051728", "GO:0090068", "GO:0110044" ]
[ "GO:0065007", "positively_regulates GO:0051728" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21506\" xsd:anyURI" ]
pg
2021-05-25T06:18:49Z
false
true
8
GO:0140649
140,649
symbiont-mediated cell-to-cell migration by invasive hypha
biological_process
The directional movement of a hyphal filament from one host cell to another. This process involves the clearance of plant-derived plasmodesmal occlusion materials, cytoskeleton based constriction of invasive hypha to traverse plasmodesmata. Septins and F-actin are reorganized into an hourglass shape at the point of max...
[ "PMID:29567712" ]
Do not confuse with ' GO:0036267 invasive filamentous growth ', which doesn't include invasion of cells within the host.
[ "cell-to-cell migration by invasive hypha", "host tissue colonization", "invasive growth", "invasive hyphae formation", "plant tissue colonization" ]
[ "EXACT", "BROAD", "BROAD", "EXACT", "BROAD" ]
[]
[]
[]
[ "GO:0106259" ]
[]
[]
[]
[ "GO:0106259" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21125\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27786\" xsd:anyURI" ]
pg
2021-05-25T07:42:38Z
false
true
2
GO:0140650
140,650
radial glia-guided pyramidal neuron migration
biological_process
The radial migration of a pyramidal neuron along radial glial cells.
[ "PMID:3760547" ]
null
[ "radial glia-dependent neuronal migration" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0001764" ]
[]
[]
[]
[ "GO:0001764" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21476\" xsd:anyURI" ]
pg
2021-05-25T12:48:12Z
false
true
4
GO:0140651
140,651
futile creatine cycle
biological_process
The phosphorylation and dephosphorylation of creatine in a futile cycle, which dissipates the high energy charge of phosphocreatine as heat without performing any mechanical or chemical work. The futile creatine cycle takes place in thermogenic fat cells and is part of adaptive thermogenesis.
[ "PMID:33597756", "PMID:33981039" ]
null
[]
[]
[]
[]
[]
[ "GO:0008152" ]
[ "has_part GO:0004111", "has_part GO:0050187", "part_of GO:1990845" ]
[ "has_part", "has_part", "part_of" ]
[ "GO:0004111", "GO:0050187", "GO:1990845" ]
[ "GO:0004111", "GO:0008152", "GO:0050187", "GO:1990845" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21517\" xsd:anyURI" ]
pg
2021-05-26T06:40:18Z
false
true
1
GO:0140652
140,652
pyripyropene A biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of pyripyropene A.
[ "GOC:ach", "PMID:21224862", "PMID:26019565" ]
null
[ "pyripyropene A anabolism", "pyripyropene A biosynthesis", "pyripyropene A formation", "pyripyropene A synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0016106" ]
[]
[]
[]
[ "GO:0016106" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21496\" xsd:anyURI" ]
pg
2021-05-27T08:33:29Z
false
true
5
GO:0140653
140,653
obsolete fumitremorgin C biosynthetic process
biological_process
OBSOLETE. The chemical reactions and pathways resulting in the formation of the indole alkaloid fumitremorgin C.
[ "GOC:ach", "PMID:19226505" ]
This term was obsoleted because it represents a pathway intermediate.
[ "fumitremorgin C anabolism", "fumitremorgin C biosynthesis", "fumitremorgin C formation", "fumitremorgin C synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:1900772" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21494\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22542\" xsd:anyURI" ]
pg
2021-05-27T08:37:11Z
true
true
2
GO:0140654
140,654
tryprostatin A biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of tryprostatin A.
[ "GOC:ach", "PMID:19226505" ]
null
[ "tryprostatin A anabolism", "tryprostatin A biosynthesis", "tryprostatin A formation", "tryprostatin A synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0035835", "GO:0042435", "GO:1901503" ]
[]
[]
[]
[ "GO:0035835", "GO:0042435", "GO:1901503" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21495\" xsd:anyURI" ]
pg
2021-05-27T08:39:56Z
false
true
3
GO:0140656
140,656
endodeoxyribonuclease activator activity
molecular_function
Binds to and increases the activity of an endodeoxyribonuclease.
[ "PMID:33836577" ]
null
[]
[]
[]
[]
[]
[ "GO:0170053" ]
[ "positively_regulates GO:0004520" ]
[ "positively_regulates" ]
[ "GO:0004520" ]
[ "GO:0004520", "GO:0170053" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21574\" xsd:anyURI" ]
pg
2021-06-10T13:31:54Z
false
true
3
GO:0140657
140,657
ATP-dependent activity
molecular_function
A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.
[ "PMID:24878343", "PMID:25750732", "PMID:32933017", "PMID:33818025", "PMID:33873056", "PMID:33988324" ]
Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'.
[ "ATP hydrolysis-dependent activity", "ATPase activity", "ATPase activity, coupled", "ATPase-dependent activity" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[ "gocheck_do_not_annotate", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_prokaryote", "goslim_yeast" ]
[]
[ "GO:0003674" ]
[ "has_part GO:0016887" ]
[ "has_part" ]
[ "GO:0016887" ]
[ "GO:0003674", "GO:0016887" ]
[ "GO:0003674", "has_part GO:0016887" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21612\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22371\" xsd:anyURI" ]
pg
2021-06-15T07:35:06Z
false
true
3
GO:0140658
140,658
ATP-dependent chromatin remodeler activity
molecular_function
An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling.
[ "PMID:14729263", "PMID:19165147", "PMID:21862382", "PMID:30867599", "PMID:34313222" ]
null
[ "ATP hydrolysis-dependent chromatin remodeler activity", "ATP-dependent chromatin remodeller activity", "ATP-dependent chromatin remodelling", "ATPase-dependent chromatin remodeler activity", "nucleosome-activated ATPase activity", "nucleosome-dependent ATPase activity" ]
[ "EXACT", "EXACT", "RELATED", "EXACT", "RELATED", "RELATED" ]
[ "GO:0070615" ]
[]
[]
[ "GO:0008094" ]
[ "has_part GO:0003677", "part_of GO:0006338" ]
[ "has_part", "part_of" ]
[ "GO:0003677", "GO:0006338" ]
[ "GO:0003677", "GO:0006338", "GO:0008094" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21609\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21786\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/6075\" xsd:anyURI" ]
pg
2021-06-15T13:57:18Z
false
true
9
GO:0140659
140,659
cytoskeletal motor regulator activity
molecular_function
Binds to and modulates the activity of a motor protein.
[ "PMID:23142046", "PMID:33221250" ]
null
[ "motor activity regulator activity" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0098772" ]
[ "regulates GO:0003774" ]
[ "regulates" ]
[ "GO:0003774" ]
[ "GO:0003774", "GO:0098772" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21627\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21756\" xsd:anyURI" ]
pg
2021-06-16T11:16:00Z
false
true
6
GO:0140660
140,660
cytoskeletal motor activator activity
molecular_function
Binds to and increases the activity of a motor protein.
[ "PMID:33221250" ]
null
[ "motor activity activator activity" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0140659", "GO:0140677" ]
[ "positively_regulates GO:0003774" ]
[ "positively_regulates" ]
[ "GO:0003774" ]
[ "GO:0003774", "GO:0140659", "GO:0140677" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21627\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21756\" xsd:anyURI" ]
pg
2021-06-16T11:18:55Z
false
true
1
GO:0140661
140,661
cytoskeletal motor inhibitor activity
molecular_function
Binds to and stops, prevents, or reduces the activity of a motor protein.
[ "PMID:23142046" ]
null
[ "motor activity inhibitor activity" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0140659", "GO:0140678" ]
[ "negatively_regulates GO:0003774" ]
[ "negatively_regulates" ]
[ "GO:0003774" ]
[ "GO:0003774", "GO:0140659", "GO:0140678" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21627\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21756\" xsd:anyURI" ]
pg
2021-06-16T11:22:54Z
false
true
1
GO:0140662
140,662
ATP-dependent protein folding chaperone
molecular_function
Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
[ "PMID:27365453" ]
null
[]
[]
[]
[]
[]
[ "GO:0044183", "GO:0140657" ]
[]
[]
[]
[ "GO:0044183", "GO:0140657" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21660\" xsd:anyURI" ]
pg
2021-06-19T16:28:34Z
false
true
4
GO:0140663
140,663
ATP-dependent FeS chaperone activity
molecular_function
Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis.
[ "PMID:16843540" ]
null
[ "ATP-dependent FeS carrier activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0016530", "GO:0140657" ]
[]
[]
[]
[ "GO:0016530", "GO:0140657" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21661\" xsd:anyURI" ]
pg
2021-06-19T16:33:09Z
false
true
5
GO:0140664
140,664
ATP-dependent DNA damage sensor activity
molecular_function
A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis.
[ "PMID:33302090", "PMID:33510387" ]
null
[ "ATP-dependent DNA damage sensing activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0008094", "GO:0140612" ]
[]
[]
[]
[ "GO:0008094", "GO:0140612" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21662\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30980\" xsd:anyURI" ]
pg
2021-06-19T16:37:21Z
false
true
8
GO:0140665
140,665
ATP-dependent H3-H4 histone complex chaperone activity
molecular_function
A histone chaperone that carries a H3-H4 histone complex, driven by ATP hydrolysis.
[ "PMID:31848341", "PMID:33658433" ]
null
[ "ATP-dependent H3-H4 histone complex loader activity", "H3-H4 dimer loading activity", "H3-H4 histone chaperone", "H3-H4 histone complex loader activity", "histone chaperone", "histone H3-H4 dimer loading activity" ]
[ "NARROW", "EXACT", "BROAD", "BROAD", "RELATED", "EXACT" ]
[]
[]
[]
[ "GO:0000510", "GO:0140674" ]
[]
[]
[]
[ "GO:0000510", "GO:0140674" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch RHEA:13065", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21580\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21733\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]
pg
2021-06-22T13:57:16Z
false
true
8
GO:0140666
140,666
annealing activity
molecular_function
An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule.
[ "PMID:22888405" ]
null
[ "renaturation" ]
[ "RELATED" ]
[ "GO:0097617" ]
[]
[ "Reactome:R-HSA-5686642 \"RAD52 promotes single strand annealing at resected DNA DSBs\"" ]
[ "GO:0003676", "GO:0120545", "GO:0140640" ]
[]
[]
[]
[ "GO:0003676", "GO:0120545", "GO:0140640" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21614\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29334\" xsd:anyURI" ]
pr
2014-06-13T10:18:43Z
false
true
3
GO:0140670
140,670
cohesin unloader activity
molecular_function
Facilitating a conformational change to unload a cohesin complex from sister chromatids.
[ "PMID:26687354" ]
null
[ "cohesin unloading activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0140097" ]
[]
[]
[]
[ "GO:0140097" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21700\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23400\" xsd:anyURI" ]
pg
2021-06-24T13:36:05Z
false
true
2
GO:0140671
140,671
ADA complex
cellular_component
A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and H2B. In budding yeast shares the histone acetylation (HAT) module of ADA2-GCN5-NGG1-SGF29 with the related SAGA complex.
[ "GOC:bhm", "PMID:21734642", "PMID:28966424" ]
null
[ "ADA HAT complex", "ADA histone acetyltransferase complex", "Ada2/Gcn5/Ada3 transcription activator complex", "scADA" ]
[ "EXACT", "EXACT", "RELATED", "NARROW" ]
[]
[]
[]
[ "GO:0070461" ]
[]
[]
[]
[ "GO:0070461" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21335\" xsd:anyURI" ]
pg
2021-06-25T11:02:49Z
false
true
9
GO:0140672
140,672
ATAC complex
cellular_component
A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive...
[ "GOC:bhm", "PMID:19936620", "PMID:20562830", "PMID:28966424" ]
null
[ "Ada two A containing complex", "Ada Two-A containing complex", "Ada-Two-A-containing complex", "ADA2A-containing complex", "G-ATAC complex", "KAT2A-containing ATAC complex", "KAT2B-containing ATAC complex" ]
[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0070461" ]
[]
[]
[]
[ "GO:0070461" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21335\" xsd:anyURI" ]
pg
2021-06-25T11:05:14Z
false
true
7
GO:0140673
140,673
transcription elongation-coupled chromatin remodeling
biological_process
A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation.
[ "PMID:22922743", "PMID:28053344" ]
Note: Do not confuse with 'GO:0045815 transcriptional initiation-coupled chromatin remodeling', which describes the maintenance of chromatin in an open conformation, allowing the transcriptional machinery to access the DNA.
[ "chromatin maintenance during transcription elongation", "co-transcriptional chromatin reassembly", "DNA replication-independent chromatin organization", "euchromatin maintenance during transcription elongation", "maintenance of chromatin integrity during transcription elongation by RNAPII", "maintenance ...
[ "RELATED", "EXACT", "RELATED", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0006338" ]
[ "part_of GO:0006368" ]
[ "part_of" ]
[ "GO:0006368" ]
[ "GO:0006338", "GO:0006368" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21730\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23696\" xsd:anyURI" ]
pg
2021-06-29T09:18:46Z
false
true
7
GO:0140674
140,674
ATP-dependent histone chaperone activity
molecular_function
Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome, driven by ATP hydrolysis.
[ "PMID:26459557" ]
null
[ "ATP-dependent histone loader activity", "ATP-dependent histone unloader activity", "histone loader activity", "histone loading activity", "histone unloader activity", "histone unloading activity", "nucleosome remodeling activity" ]
[ "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "RELATED" ]
[ "GO:0140675" ]
[]
[]
[ "GO:0140096", "GO:0140658", "GO:0140713" ]
[]
[]
[]
[ "GO:0140096", "GO:0140658", "GO:0140713" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21733\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22129\" xsd:anyURI" ]
pg
2021-06-29T12:42:57Z
false
true
4
GO:0140676
140,676
oscillatory cAMP signaling
biological_process
Fluctuation in the extracellular cAMP levels due to the alternate activation of adenylate cyclase, which produces cAMP, and phosphodiesterase, which degrades it. Occurs in Dictyostelium during early sorocarp development. Oscillation in signaling result is directional chemotaxis of cells towards the center of the aggreg...
[ "PMID:18657484" ]
null
[ "cAMP relay" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0007267" ]
[ "has_part GO:0004115", "has_part GO:0140582" ]
[ "has_part", "has_part" ]
[ "GO:0004115", "GO:0140582" ]
[ "GO:0004115", "GO:0007267", "GO:0140582" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21369\" xsd:anyURI" ]
pg
2021-06-29T14:14:39Z
false
true
5
GO:0140677
140,677
molecular function activator activity
molecular_function
A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target.
[ "GOC:curators" ]
This term should only be used in cases when the regulator directly interacts with the enzyme, but does not result in a covalent modification.
[]
[]
[]
[]
[ "Reactome:R-HSA-8866941 \"MID1IP1 binds THRSP\"" ]
[ "GO:0098772" ]
[]
[]
[]
[ "GO:0098772" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21782\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25165\" xsd:anyURI" ]
pg
2021-07-07T07:24:16Z
false
true
9
GO:0140678
140,678
molecular function inhibitor activity
molecular_function
A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target.
[ "GOC:curators" ]
This term should only be used in cases when the regulator directly interacts with the enzyme, but does not result in a covalent modification.
[]
[]
[]
[]
[]
[ "GO:0098772" ]
[]
[]
[]
[ "GO:0098772" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21782\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25165\" xsd:anyURI" ]
pg
2021-07-07T07:24:32Z
false
true
8
GO:0140679
140,679
ABC-type sodium transporter activity
molecular_function
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na(in) = ADP + phosphate + Na(out).
[ "PMID:9106203" ]
null
[]
[]
[]
[]
[ "EC:7.2.2.4", "TC:3.A.1.115.1" ]
[ "GO:0015081", "GO:0019829", "GO:0140359" ]
[]
[]
[]
[ "GO:0015081", "GO:0019829", "GO:0140359" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch MetaCyc:RXN-17739", "skos:broadMatch RHEA:14633", "skos:exactMatch EC:7.2.2.4", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21796\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26941\" xsd:anyURI", "term_tracker_item \"ht...
pg
2021-07-08T11:22:56Z
false
true
6
GO:0140680
140,680
histone H3K36me/H3K36me2 demethylase activity
molecular_function
Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
[ "PMID:20531378" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3-di/monomethyl-lysine-36 demethylase activity", "histone H3K36me demethylase activity", "histone H3K36me2 demethylase activity" ]
[ "EXACT", "RELATED", "BROAD" ]
[]
[]
[ "EC:1.14.11.27", "MetaCyc:RXN-13186", "RHEA:42032" ]
[ "GO:0051864" ]
[]
[]
[]
[ "GO:0051864" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.14.11.27", "skos:exactMatch RHEA:42032", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21089\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28199\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ont...
pg
2021-07-08T14:12:22Z
false
true
6
GO:0140681
140,681
histone H3K36me2/H3K36me3 demethylase activity
molecular_function
Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
[ "PMID:21914792" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3-tri/dimethyl-lysine-36 demethylase activity", "histone H3K36me2 demethylase activity", "histone H3K36me3 demethylase activity" ]
[ "EXACT", "BROAD", "RELATED" ]
[]
[]
[ "EC:1.14.11.69", "MetaCyc:RXN-20643", "RHEA:60236" ]
[ "GO:0051864" ]
[]
[]
[]
[ "GO:0051864" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.14.11.69", "skos:exactMatch RHEA:60236", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21089\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25808\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ont...
pg
2021-07-08T14:12:31Z
false
true
8
GO:0140682
140,682
FAD-dependent H3K4me/H3K4me3 demethylase activity
molecular_function
Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction.
[ "PMID:22473470" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity", "histone H3K4me demethylase activity", "histone H3K4me2 demethylase activity" ]
[ "EXACT", "RELATED", "BROAD" ]
[]
[]
[ "EC:1.14.99.66", "RHEA:60244" ]
[ "GO:0016705", "GO:0032453" ]
[]
[]
[]
[ "GO:0016705", "GO:0032453" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.14.99.66", "skos:exactMatch RHEA:60244", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21089\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ont...
pg
2021-07-08T15:45:22Z
false
true
7
GO:0140683
140,683
histone H3K9me/H3K9me2 demethylase activity
molecular_function
Catalysis of the removal of a methyl group from a di or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
[ "PMID:16603238" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3-di/monomethyl-lysine-9 demethylase activity", "histone H3K9me demethylase activity", "histone H3K9me2 demethylase activity" ]
[ "EXACT", "BROAD", "BROAD" ]
[]
[]
[ "EC:1.14.11.65", "RHEA:60188" ]
[ "GO:0016706", "GO:0032454" ]
[]
[]
[]
[ "GO:0016706", "GO:0032454" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.14.11.65", "skos:exactMatch RHEA:60188", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21089\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ont...
pg
2021-07-09T06:03:06Z
false
true
9
GO:0140684
140,684
histone H3K9me2/H3K9me3 demethylase activity
molecular_function
Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
[ "PMID:20208542", "PMID:20531378" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3-tri/dimethyl-lysine-9 demethylase activity", "histone H3K9me2 demethylase activity", "histone H3K9me3 demethylase activity" ]
[ "EXACT", "BROAD", "RELATED" ]
[]
[]
[ "EC:1.14.11.66", "RHEA:60200" ]
[ "GO:0016706", "GO:0032454" ]
[]
[]
[]
[ "GO:0016706", "GO:0032454" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.14.11.66", "skos:exactMatch RHEA:60200", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21089\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ont...
pg
2021-07-09T06:03:55Z
false
true
7
GO:0140685
140,685
FAD-dependent histone H3K9me/H3K9me2 demethylase activity
molecular_function
Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction.
[ "PMID:22473470" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3-di/monomethyl-lysine-9 FAD-dependent demethylase activity", "histone H3K9me demethylase activity", "histone H3K9me2 demethylase activity" ]
[ "EXACT", "BROAD", "BROAD" ]
[]
[]
[]
[ "GO:0016705", "GO:0032454" ]
[]
[]
[]
[ "GO:0016705", "GO:0032454" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:1.14.11.65", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21089\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI"...
pg
2021-07-09T07:18:00Z
false
true
2
GO:0140690
140,690
dihydropyrimidine dehydrogenase (NAD+) complex
cellular_component
A heteromultimeric complex capable of dihydropyrimidine dehydrogenase (NAD+); in E. coli, composed of PreA and PreT.
[ "PMID:21169495", "PMID:34097066" ]
null
[]
[]
[]
[]
[]
[ "GO:1990204" ]
[]
[]
[]
[ "GO:1990204" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21891\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28527\" xsd:anyURI" ]
pg
2021-08-04T05:52:44Z
false
true
6
GO:0140691
140,691
RNA folding chaperone
molecular_function
Binding to an RNA or an RNA-containing complex to assist the folding process.
[ "PMID:31165735" ]
null
[]
[]
[]
[]
[]
[ "GO:0003674" ]
[ "part_of GO:0034337" ]
[ "part_of" ]
[ "GO:0034337" ]
[ "GO:0003674", "GO:0034337" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21913\" xsd:anyURI" ]
pg
2021-08-04T07:48:29Z
false
true
6
GO:0140692
140,692
very long-chain fatty acid omega-hydroxylase activity
molecular_function
Catalysis of the reaction: an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an omega-hydroxy-very-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.
[ "PMID:16547005", "RHEA:67952" ]
While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
[]
[]
[]
[]
[ "RHEA:39719", "RHEA:40083", "RHEA:67952" ]
[ "GO:0120250" ]
[]
[]
[]
[ "GO:0120250" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch RHEA:67952", "skos:narrowMatch RHEA:39719", "skos:narrowMatch RHEA:40083", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21925\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26445\" xsd:anyURI", "term_tracker_item \"https:/...
pg
2021-08-05T07:41:17Z
false
true
1
GO:0140694
140,694
membraneless organelle assembly
biological_process
The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle.
[ "PMID:28225081" ]
null
[ "non-membrane-bounded organelle assembly", "non-membrane-bounded organelle formation", "non-membrane-enclosed organelle assembly", "non-membrane-enclosed organelle formation" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0070925" ]
[]
[]
[]
[ "GO:0070925" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21939\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29106\" xsd:anyURI" ]
pg
2021-08-09T15:30:06Z
false
true
2
GO:0140696
140,696
(S)-2-hydroxyglutarate dehydrogenase (quinone) activity
molecular_function
Catalysis of the reaction: (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol.
[ "PMID:30498244", "RHEA:58664" ]
null
[ "(S)-2-hydroxyglutarate dehydrogenase activity", "L-2-hydroxyglutarate dehydrogenase activity" ]
[ "BROAD", "EXACT" ]
[]
[]
[ "EC:1.1.5.13", "MetaCyc:RXN0-7319", "RHEA:58664" ]
[ "GO:0016901", "GO:0047545" ]
[]
[]
[]
[ "GO:0016901", "GO:0047545" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.1.5.13", "skos:exactMatch RHEA:58664", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21957\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30707\" xsd:anyURI" ]
pg
2021-08-11T14:16:32Z
false
true
3
GO:0140699
140,699
cyclic GMP-AMP synthase activity
molecular_function
Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP.
[ "PMID:23258413" ]
Note that this term should not be used for direct annotation. It should be possible to annotate to a more specific child term that describes the position of the phosphate group on the cGAMP molecule.
[ "cyclic-GMP-AMP synthase activity" ]
[ "EXACT" ]
[]
[ "gocheck_do_not_annotate" ]
[]
[ "GO:0016779" ]
[]
[]
[]
[ "GO:0016779" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21980\" xsd:anyURI" ]
pg
2021-08-27T05:05:37Z
false
true
4
GO:0140700
140,700
3',2'-cyclic GMP-AMP synthase activity
molecular_function
Catalysis of the reaction: GTP + ATP = 3',2'-cGAMP + 2 diphosphate.
[ "PMID:34261127", "RHEA:68344" ]
null
[ "3',2' cyclic-GMP-AMP synthase activity", "3',2'-cyclic GAMP synthase activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[ "RHEA:68344" ]
[ "GO:0140699" ]
[]
[]
[]
[ "GO:0140699" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch RHEA:68344", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21980\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30714\" xsd:anyURI" ]
pg
2021-08-27T05:11:54Z
false
true
3
GO:0140701
140,701
3',3'-cyclic GMP-AMP synthase activity
molecular_function
Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(3'-5') (cyclic 3',3' GAMP).
[ "PMID:30787435", "RHEA:35647" ]
null
[ "3',3' cyclic-GAMP synthase activity", "3',3' cyclic-GMP-AMP synthase activity", "3',3'-cyclic GAMP synthase activity" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[ "RHEA:35647" ]
[ "GO:0140699" ]
[]
[]
[]
[ "GO:0140699" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch RHEA:35647", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21980\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
pg
2021-08-27T05:13:09Z
false
true
4
GO:0140702
140,702
cyclic GMP-AMP binding
molecular_function
Binding to cyclic GMP-AMP (cGAMP) nucleotide.
[ "PMID:23258412" ]
null
[]
[]
[]
[ "gocheck_do_not_annotate" ]
[]
[ "GO:0030551" ]
[]
[]
[]
[ "GO:0030551" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21980\" xsd:anyURI" ]
pg
2021-08-27T05:39:31Z
false
true
2
GO:0140703
140,703
3',3'-cyclic GMP-AMP binding
molecular_function
Binding to 3',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 3',5' linkages.
[ "PMID:30787435" ]
null
[ "3',3' cyclic-GMP-AMP binding", "3',3'-cGAMP binding", "3',3'-cGMP-AMP binding", "3',3'-cyclic GAMP binding" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0032559", "GO:0032561", "GO:0043168", "GO:0140702" ]
[]
[]
[]
[ "GO:0032559", "GO:0032561", "GO:0043168", "GO:0140702" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21980\" xsd:anyURI" ]
pg
2021-08-27T05:44:15Z
false
true
1
GO:0140704
140,704
3',2'-cyclic GMP-AMP binding
molecular_function
Binding to 3',2' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 2',5' linkages.
[ "PMID:34261127" ]
null
[ "3',2' cyclic-GMP-AMP binding", "3',2'-cGAMP binding", "3',2'-cyclic GAMP binding" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0043168" ]
[]
[]
[]
[ "GO:0043168" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21980\" xsd:anyURI" ]
pg
2021-08-27T05:44:28Z
false
true
9
GO:0140706
140,706
protein-containing complex localization to centriolar satellite
biological_process
A protein-containing complex localization by which the complex is transported to, or maintained in, the centriolar satellite.
[ "PMID:27979967" ]
null
[]
[]
[]
[]
[]
[ "GO:0031503" ]
[]
[]
[]
[ "GO:0031503" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22020\" xsd:anyURI" ]
pg
2021-09-01T05:59:13Z
false
true
9
GO:0140708
140,708
CAT tailing
biological_process
The C-terminal elongation of 60S-anchored stalled nascent polypeptide chains with untemplated alanine and threonine tails (CAT tails). CAT tails participate in the recognition of stalled nascent chains by the ribosome quality control system.
[ "PMID:25554787", "PMID:32934225" ]
null
[]
[]
[]
[]
[]
[ "GO:0002182" ]
[ "part_of GO:0072344", "part_of GO:1990116" ]
[ "part_of", "part_of" ]
[ "GO:0072344", "GO:1990116" ]
[ "GO:0002182", "GO:0072344", "GO:1990116" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21987\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23474\" xsd:anyURI" ]
pg
2021-09-03T13:16:20Z
false
true
6
GO:0140709
140,709
Frizzled Nuclear Import pathway
biological_process
A type of non-canonical Wnt signaling in which Wnt binding to its receptor on the surface a the target cell results in internalization and cleavage of the frizzled receptor to yield a C-terminal fragment that is imported into the nucleus. The frizzled C-terminal fragment is incorporated into large ribonucleoprotein par...
[ "PMID:22510459", "PMID:22579286" ]
null
[ "FNI", "Frizzled Nuclear Import Wnt Pathway" ]
[ "BROAD", "EXACT" ]
[]
[]
[]
[ "GO:0035567" ]
[]
[]
[]
[ "GO:0035567" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21483\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26335\" xsd:anyURI" ]
pg
2021-09-08T09:11:25Z
false
true
3
GO:0140710
140,710
regulation of Frizzled Nuclear Import pathway
biological_process
Any process that modulates the frequency, rate or extent of a Frizzled Nuclear Import pathway.
[ "PMID:22510459", "PMID:22579286" ]
null
[ "regulation of FNI", "regulation of Frizzled Nuclear Import Wnt Pathway" ]
[ "BROAD", "EXACT" ]
[]
[]
[]
[ "GO:2000050" ]
[ "regulates GO:0140709" ]
[ "regulates" ]
[ "GO:0140709" ]
[ "GO:0140709", "GO:2000050" ]
[ "GO:0065007", "regulates GO:0140709" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21483\" xsd:anyURI" ]
pg
2021-09-08T09:14:01Z
false
true
4
GO:0140711
140,711
positive regulation of Frizzled Nuclear Import pathway
biological_process
Any process that activates or increases the frequency, rate or extent of a Frizzled Nuclear Import pathway.
[ "PMID:22510459", "PMID:22579286" ]
null
[ "positive regulation of FNI", "positive regulation of Frizzled Nuclear Import Wnt Pathway" ]
[ "BROAD", "EXACT" ]
[]
[]
[]
[ "GO:0140710", "GO:2000052" ]
[ "positively_regulates GO:0140709" ]
[ "positively_regulates" ]
[ "GO:0140709" ]
[ "GO:0140709", "GO:0140710", "GO:2000052" ]
[ "GO:0065007", "positively_regulates GO:0140709" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21483\" xsd:anyURI" ]
pg
2021-09-08T09:17:38Z
false
true
3
GO:0140712
140,712
negative regulation of Frizzled Nuclear Import pathway
biological_process
Any process that stops, prevents, or reduces the frequency, rate or extent of a Frizzled Nuclear Import pathway.
[ "PMID:22510459", "PMID:22579286" ]
null
[ "negative regulation of FNI", "negative regulation of Frizzled Nuclear Import Wnt Pathway" ]
[ "BROAD", "EXACT" ]
[]
[]
[]
[ "GO:0140710", "GO:2000051" ]
[ "negatively_regulates GO:0140709" ]
[ "negatively_regulates" ]
[ "GO:0140709" ]
[ "GO:0140709", "GO:0140710", "GO:2000051" ]
[ "GO:0065007", "negatively_regulates GO:0140709" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21483\" xsd:anyURI" ]
pg
2021-09-08T09:18:32Z
false
true
5
GO:0140713
140,713
histone chaperone activity
molecular_function
Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone).
[ "PMID:26459557" ]
null
[ "histone carrier activity", "nucleosome remodeling activity" ]
[ "EXACT", "RELATED" ]
[]
[]
[ "Reactome:R-HSA-9822185 \"HIRA and NPM2 assemble H3.3-containing nucleosomes on paternal DNA\"" ]
[ "GO:0140597" ]
[ "has_part GO:0042393" ]
[ "has_part" ]
[ "GO:0042393" ]
[ "GO:0042393", "GO:0140597" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22126\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22129\" xsd:anyURI" ]
pg
2021-09-10T15:22:31Z
false
true
5
GO:0140714
140,714
large ribosomal subunit pre-assembly complex
cellular_component
A protein complex that assists early maturation of nascent 60S ribosomal subunits. The complex interacts with the large ribosomal subunit rRNA via one of the components (Urb2 in S. cerevisiae) and requires a RNA helicase (Dbp6 in S. cerevisiae).
[ "GOC:lnp", "PMID:17145778", "PMID:9528757" ]
null
[]
[]
[]
[]
[]
[ "GO:0101031" ]
[]
[]
[]
[ "GO:0101031" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15279\" xsd:anyURI" ]
pg
2021-09-15T12:17:56Z
false
true
8
GO:0140715
140,715
serine-tRNA ligase complex
cellular_component
A heterodimeric enzyme complex that catalyzes the ligation of serine to tRNA(Ser), forming L-seryl-tRNA(Ser).
[ "PMID:30943413" ]
null
[]
[]
[]
[]
[]
[ "GO:1902494" ]
[]
[]
[]
[ "GO:1902494" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22145\" xsd:anyURI" ]
pg
2021-09-15T12:38:41Z
false
true
7