Datasets:
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GO

Dataset card Data Studio Files
xet
 Community
go_id
string
go_numeric_id
int64
name
string
namespace
string
definition
string
definition_xrefs
list
comment
string
synonyms
list
synonym_scopes
list
alt_ids
list
subsets
list
xrefs
list
is_a_ids
list
relationship_edges
list
relationship_types
list
relationship_target_ids
list
parent_ids
list
intersection_of
list
union_of
list
disjoint_from
list
replaced_by
list
consider
list
property_values
list
created_by
string
creation_date
string
is_obsolete
bool
in_go_basic
bool
split_bucket
int64
GO:0140936
140,936
histone H2B deubiquitinase activity
molecular_function
A histone deubiquitinase that cleaves ubiquitin from a histone H2B protein to which it is conjugated.
[ "PMID:18206972", "PMID:29352077" ]
null
[ "histone H2B deubiquitination" ]
[ "RELATED" ]
[]
[]
[]
[ "GO:0140934" ]
[]
[]
[]
[ "GO:0140934" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22769\" xsd:anyURI" ]
pg
2022-11-01T08:10:30Z
false
true
8
GO:0140937
140,937
histone H4K12 deacetylase activity, hydrolytic mechanism
molecular_function
Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 12) + H2O = histone H4 L-lysine (position 12) + acetate. This reaction represents the removal of an acetyl group from lysine at position 12 of the histone H4 protein.
[ "GOC:vw", "PMID:15293224" ]
Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
[ "histone deacetylase activity (H4-K12 specific)", "histone H4-K12 deacetylase activity", "histone H4-K12 deacetylation", "histone H4K12 deacetylase activity", "histone H4K12 deacetylation" ]
[ "EXACT", "EXACT", "RELATED", "BROAD", "RELATED" ]
[]
[]
[]
[ "GO:0141051", "GO:0141221" ]
[]
[]
[]
[ "GO:0141051", "GO:0141221" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:3.5.1.98", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22769\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29468\" xsd:anyURI", ...
pg
2022-11-01T08:12:49Z
false
true
3
GO:0140938
140,938
histone H3 methyltransferase activity
molecular_function
Catalysis of the reaction: S-adenosyl-L-methionine + a histone H3 = S-adenosyl-L-homocysteine + a methylated histone H3. Histone methylation generally occurs on either an arginine or a lysine residue.
[ "PMID:28450737" ]
null
[ "histone H3 methylase activity", "histone H3 methylation" ]
[ "EXACT", "RELATED" ]
[]
[]
[ "Reactome:R-HSA-3788745 \"EHMT1:EHMT2 methylates IL8 promoter\"", "Reactome:R-HSA-3788748 \"EHMT1:EHMT2 methylates IL6 promoter\"", "Reactome:R-HSA-4827382 \"SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)\"", "Reactome:R-HSA-4827383 \"WHSC1 (...
[ "GO:0042054" ]
[]
[]
[]
[ "GO:0042054" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI" ]
pg
2022-11-01T08:25:30Z
false
true
3
GO:0140939
140,939
histone H4 methyltransferase activity
molecular_function
Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H4 = S-adenosyl-L-homocysteine + a methylated histone H4. Histone methylation generally occurs on either an arginine or a lysine residue.
[ "PMID:28450737" ]
null
[ "histone H4 methylase activity", "histone H4 methylation" ]
[ "EXACT", "EXACT" ]
[]
[]
[ "Reactome:R-HSA-5423038 \"SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)\"", "Reactome:R-HSA-5651654 \"SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)\"", "Reactome:R-HSA-5651657 \"SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dime...
[ "GO:0042054" ]
[]
[]
[]
[ "GO:0042054" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI" ]
pg
2022-11-01T08:29:21Z
false
true
4
GO:0140940
140,940
histone H2A methyltransferase activity
molecular_function
Catalysis of the reaction: S-adenosyl-L-methionine + a histone H2 = S-adenosyl-L-homocysteine + a methylated histone H2A. Histone methylation generally occurs on either an arginine or a lysine residue.
[ "PMID:28450737" ]
null
[ "histone H2A methylase activity", "histone H2A methylation" ]
[ "EXACT", "RELATED" ]
[]
[]
[]
[ "GO:0042054" ]
[]
[]
[]
[ "GO:0042054" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI" ]
pg
2022-11-01T09:07:02Z
false
true
9
GO:0140941
140,941
histone H4K20me methyltransferase activity
molecular_function
Catalysis of the reaction: N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H+ + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the monomethylated lysine residue at position 20 of histone H4, producing H4K20me2.
[ "RHEA:60348" ]
Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
[ "histone H4 methyl lysine(20) N-methyltransferase activity (H4-K20 specific)", "histone H4-K20 dimethylation", "histone H4K20 dimethylation", "histone H4K20me methylase activity" ]
[ "EXACT", "BROAD", "BROAD", "EXACT" ]
[]
[]
[ "EC:2.1.1.362", "RHEA:60348" ]
[ "GO:0042799" ]
[]
[]
[]
[ "GO:0042799" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.1.1.362", "skos:exactMatch RHEA:60348", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-onto...
pg
2022-11-01T09:25:37Z
false
true
6
GO:0140942
140,942
histone H3K9 dimethyltransferase activity
molecular_function
Catalysis of the reaction: L-lysyl9-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl9-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me2.
[ "RHEA:64444" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3-K9 dimethylation", "histone H3K9 dimethylase activity", "histone H3K9 dimethylation", "histone H3K9 mono/dimethylase activity", "histone lysine N-dimethyltransferase activity (H3-K9 specific)" ]
[ "BROAD", "EXACT", "BROAD", "EXACT", "EXACT" ]
[]
[]
[ "EC:2.1.1.368", "RHEA:64444" ]
[ "GO:0046974" ]
[]
[]
[]
[ "GO:0046974" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.1.1.368", "skos:exactMatch RHEA:64444", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-onto...
pg
2022-11-01T09:35:23Z
false
true
3
GO:0140943
140,943
histone H4K20 trimethyltransferase activity
molecular_function
Catalysis of the reaction: L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H+ + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine. This reaction is the addition of three methyl groups to the lysine residue at position 20 of the histone H4 protein, producing histone H4K20me3.
[ "RHEA:64456" ]
Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
[ "histone H4K20 trimethylase activity", "histone H4K20 trimethylation", "histone lysine N-trimethyltransferase activity (H4-K20 specific)" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[ "EC:2.1.1.372", "RHEA:64456" ]
[ "GO:0042799" ]
[]
[]
[]
[ "GO:0042799" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.1.1.372", "skos:exactMatch RHEA:64456", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-onto...
pg
2022-11-01T09:44:02Z
false
true
4
GO:0140944
140,944
histone H4K20 monomethyltransferase activity
molecular_function
Catalysis of the reaction: L-lysyl20-[histone H4] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl20-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 20 of histone H4, producing histone H4K20me.
[ "RHEA:60344" ]
Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
[ "histone H4-K20 methylation", "histone H4K20 methylase activity", "histone H4K20 methylation", "histone H4K20 monomethylation", "histone lysine N-monomethyltransferase activity (H4-K20 specific)" ]
[ "BROAD", "BROAD", "BROAD", "EXACT", "EXACT" ]
[]
[]
[ "EC:2.1.1.361", "RHEA:60344" ]
[ "GO:0042799" ]
[]
[]
[]
[ "GO:0042799" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.1.1.361", "skos:exactMatch RHEA:60344", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-onto...
pg
2022-11-01T09:50:43Z
false
true
9
GO:0140945
140,945
histone H3K4 monomethyltransferase activity
molecular_function
Catalysis of the reaction: L-lysyl4-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me.
[ "RHEA:60264" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3K4 monomethylase activity", "histone H4-K4 methylation", "histone H4K4 methylation", "histone lysine N-monomethyltransferase activity (H3-K4 specific)" ]
[ "EXACT", "BROAD", "BROAD", "EXACT" ]
[]
[]
[ "EC:2.1.1.364", "RHEA:60264" ]
[ "GO:0042800" ]
[]
[]
[]
[ "GO:0042800" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.1.1.364", "skos:exactMatch RHEA:60264", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-onto...
pg
2022-11-01T09:57:25Z
false
true
9
GO:0140946
140,946
histone H3K4 dimethyltransferase activity
molecular_function
Catalysis of the reaction: L-lysyl4-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl4-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me2.
[ "RHEA:64448" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3-K4 dimethylation", "histone H3K4 dimethylase activity", "histone H3K4 dimethylation", "histone lysine N-dimethyltransferase activity (H3-K4 specific)" ]
[ "BROAD", "EXACT", "BROAD", "EXACT" ]
[]
[]
[ "EC:2.1.1.370", "RHEA:64448" ]
[ "GO:0042800" ]
[]
[]
[]
[ "GO:0042800" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.1.1.370", "skos:exactMatch RHEA:64448", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-onto...
pg
2022-11-01T10:01:55Z
false
true
2
GO:0140947
140,947
histone H3K9me2 methyltransferase activity
molecular_function
Catalysis of the reaction: N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the dimethylated lysine residue at position 9 of histone H3, producing histone H3K9me3.
[ "RHEA:60288" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone dimethyl-lysine(H3K9) N-methyltransferase activity (H3-K9 specific)", "histone H3-K9 trimethylation", "histone H3K9 trimethylation", "histone H3K9me2 methylase activity" ]
[ "EXACT", "BROAD", "BROAD", "EXACT" ]
[]
[]
[ "EC:2.1.1.366", "RHEA:60288" ]
[ "GO:0046974" ]
[]
[]
[]
[ "GO:0046974" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.1.1.366", "skos:exactMatch RHEA:60288", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-onto...
pg
2022-11-01T10:17:34Z
false
true
6
GO:0140949
140,949
histone H3K9 trimethyltransferase activity
molecular_function
Catalysis of the reaction: L-lysyl9-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me3.
[ "RHEA:60276" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3-K9 trimethylation", "histone H3K9 mono/di/trimethylase activity", "histone H3K9 trimethylase activity", "histone H3K9 trimethylation", "histone lysine N-trimethyltransferase activity (H3-K9 specific)" ]
[ "BROAD", "EXACT", "EXACT", "BROAD", "EXACT" ]
[]
[]
[ "EC:2.1.1.355", "RHEA:60276" ]
[ "GO:0046974" ]
[]
[]
[]
[ "GO:0046974" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.1.1.355", "skos:exactMatch RHEA:60276", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-onto...
pg
2022-11-01T10:49:29Z
false
true
7
GO:0140950
140,950
histone H2A deubiquitinase activity
molecular_function
A histone deubiquitinase that cleaves ubiquitin from a histone H2A protein to which it is conjugated.
[ "PMID:18226187", "PMID:20436459" ]
null
[ "histone H2A deubiquitination" ]
[ "RELATED" ]
[]
[]
[]
[ "GO:0140934" ]
[]
[]
[]
[ "GO:0140934" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22769\" xsd:anyURI" ]
pg
2022-11-01T11:11:26Z
false
true
5
GO:0140951
140,951
histone H3K27 trimethyltransferase activity
molecular_function
Catalysis of the reaction: L-lysyl27-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me3.
[ "RHEA:60292" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3-K27 trimethylase activity", "histone H3-K27 trimethylation", "histone H3K27 mono/di/trimethylase activity", "histone H3K27 trimethylase activity", "histone H3K27 trimethylation", "histone lysine N-trimethyltransferase activity (H3-K27 specific)" ]
[ "EXACT", "BROAD", "EXACT", "EXACT", "BROAD", "EXACT" ]
[]
[]
[ "EC:2.1.1.356", "RHEA:60292" ]
[ "GO:0046976" ]
[]
[]
[]
[ "GO:0046976" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch RHEA:60292", "skos:narrowMatch EC:2.1.1.356", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ont...
pg
2022-11-01T13:26:01Z
false
true
2
GO:0140952
140,952
histone H3K27 dimethyltransferase activity
molecular_function
Catalysis of the reaction: L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2.
[ "RHEA:64452" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3-K27 dimethylase activity", "histone H3-K27 dimethylation", "histone H3K27 dimethylase activity", "histone H3K27 dimethylation", "histone H3K27 mono/dimethylase activity", "histone lysine N-dimethyltransferase activity (H3-K27 specific)" ]
[ "EXACT", "BROAD", "EXACT", "BROAD", "EXACT", "EXACT" ]
[]
[]
[ "EC:2.1.1.371", "RHEA:64452" ]
[ "GO:0046976" ]
[]
[]
[]
[ "GO:0046976" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.1.1.371", "skos:exactMatch RHEA:64452", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-onto...
pg
2022-11-01T14:44:31Z
false
true
5
GO:0140953
140,953
histone H3K27 monomethyltransferase activity
molecular_function
Catalysis of the reaction: L-lysyl27-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl27-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me.
[ "RHEA:60296" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3-K27 methylation", "histone H3-K27 monomethylase activity", "histone H3K27 methylation", "histone H3K27 monomethylase activity", "histone lysine N-monomethyltransferase activity (H3-K27 specific)" ]
[ "BROAD", "EXACT", "BROAD", "EXACT", "EXACT" ]
[]
[]
[ "EC:2.1.1.369", "RHEA:60296" ]
[ "GO:0046976" ]
[]
[]
[]
[ "GO:0046976" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.1.1.369", "skos:exactMatch RHEA:60296", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-onto...
pg
2022-11-01T14:57:17Z
false
true
9
GO:0140954
140,954
histone H3K36 dimethyltransferase activity
molecular_function
Catalysis of the reaction: L-lysyl36-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl36-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me2.
[ "RHEA:60308" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3-K36 dimethylation", "histone H3K36 dimethylase activity", "histone H3K36 dimethylation", "histone H3K36 mono/dimethylase activity", "histone lysine N-dimethyltransferase activity (H3-K36 specific)" ]
[ "BROAD", "EXACT", "BROAD", "EXACT", "EXACT" ]
[]
[]
[ "EC:2.1.1.357", "RHEA:60308" ]
[ "GO:0046975" ]
[]
[]
[]
[ "GO:0046975" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.1.1.357", "skos:exactMatch RHEA:60308", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-onto...
pg
2022-11-01T15:06:50Z
false
true
1
GO:0140955
140,955
histone H3K36 trimethyltransferase activity
molecular_function
Catalysis of the reaction: L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me3.
[ "RHEA:60324" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3-K36 trimethylation", "histone H3K36 mono/di/trimethylase activity", "histone H3K36 trimethylase activity", "histone H3K36 trimethylation", "histone lysine N-trimethyltransferase activity (H3-K36 specific)" ]
[ "BROAD", "EXACT", "EXACT", "BROAD", "EXACT" ]
[]
[]
[ "EC:2.1.1.359", "RHEA:60324" ]
[ "GO:0046975" ]
[]
[]
[]
[ "GO:0046975" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.1.1.359", "skos:exactMatch RHEA:60324", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-onto...
pg
2022-11-01T15:18:59Z
false
true
6
GO:0140956
140,956
histone H3K79 trimethyltransferase activity
molecular_function
Catalysis of the reaction: L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of up to three methyl group to the lysine residue at position 79 of the histone H3 protein, producing H3K79me3.
[ "PMID:15371351", "RHEA:60328" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3-K79 trimethylation", "histone H3K79 trimethylase activity", "histone H3K79 trimethylation", "histone lysine N-trimethyltransferase activity (H3-K79 specific)", "histone trimethylase activity (H3-K79 specific)", "histone trimethyltransferase activity (H3-K79 specific)", "histone-H3K79 trimeth...
[ "BROAD", "EXACT", "BROAD", "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[ "EC:2.1.1.360", "RHEA:60328" ]
[ "GO:0031151" ]
[]
[]
[]
[ "GO:0031151" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.1.1.360", "skos:exactMatch RHEA:60328", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]
pg
2022-11-01T15:47:14Z
false
true
3
GO:0140958
140,958
target-directed miRNA degradation
biological_process
The process in which a miRNA is targeted for degradation by a non-coding RNA or mRNA. The binding of an RNA to a target miRNA within a RISC complex results in either ubiquitin-mediated degradation of AGO protein or the displacement of the 3' end of the miRNA, exposing it to nucleases.
[ "PMID:33184237", "PMID:36150386" ]
null
[ "target-directed microRNA degradation", "TDMD" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0010587", "GO:0016441", "GO:0060965" ]
[]
[]
[]
[ "GO:0010587", "GO:0016441", "GO:0060965" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24359\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27844\" xsd:anyURI" ]
pg
2022-11-16T06:53:51Z
false
true
5
GO:0140959
140,959
obsolete base-pairing target-directed miRNA suppressor activity
molecular_function
OBSOLETE. An inhibitor activity that acts by base-pairing with a miRNA, exposing it to nuclease-mediated degradation.
[ "PMID:33184237", "PMID:36150386" ]
This term was obsoleted because it represents the same function as miRNA inhibitor activity, GO:0140869.
[ "base-pairing target-directed microRNA suppressor activity" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0140869" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24359\" xsd:anyURI" ]
pg
2022-11-16T07:00:15Z
true
true
7
GO:0140961
140,961
cellular detoxification of metal ion
biological_process
Any process carried out at the cellular level that reduces or removes the toxicity of a metal ion.
[ "PMID:26729300", "PMID:33046888", "PMID:34442707" ]
null
[ "cellular detoxification of metal cation" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0061687", "GO:1990748" ]
[]
[]
[]
[ "GO:0061687", "GO:1990748" ]
[]
[]
[]
[]
[]
[]
pg
2022-12-07T15:35:18Z
false
true
3
GO:0140962
140,962
multicellular organismal-level chemical homeostasis
biological_process
A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell.
[ "GOC:curators" ]
null
[ "multicellular organism level chemical homeostasis", "organismal level chemical homeostasis" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0048871", "GO:0048878" ]
[]
[]
[]
[ "GO:0048871", "GO:0048878" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24554\" xsd:anyURI" ]
pg
2022-12-12T09:11:06Z
false
true
5
GO:0140963
140,963
obsolete multicellular organismal-level auxin homeostasis
biological_process
OBSOLETE. A chemical homeostatic process involved in the maintenance of a steady state level of auxin within extracellular body fluids, such as the xylem or phloem of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell.
[ "GOC:curators" ]
This term was obsoleted because it was created by error.
[ "auxin homeostasis", "multicellular organismal auxin homeostasis" ]
[ "BROAD", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0060918" ]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24555\" xsd:anyURI" ]
pg
2022-12-12T10:35:54Z
true
true
7
GO:0140964
140,964
intracellular auxin homeostasis
biological_process
A homeostatic process involved in the maintenance of a steady state level of auxin within a cell.
[ "PMID:19506555", "PMID:22314799" ]
null
[ "auxin homeostasis", "cellular auxin homeostasis" ]
[ "BROAD", "EXACT" ]
[]
[]
[]
[ "GO:0055082" ]
[]
[]
[]
[ "GO:0055082" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24555\" xsd:anyURI" ]
pg
2022-12-12T10:37:56Z
false
true
9
GO:0140965
140,965
secondary piRNA processing
biological_process
A process leading to the generation of a functional secondary piRNA, involving a self-perpetuating piRNA loop, often called the ping-pong cycle, in which piRNAs are amplified by pairing with complementary transcripts (for example the transposable element mRNA target). In Drosophila, the processing involves the piwi pro...
[ "PMID:29281264", "PMID:32895365" ]
null
[ "ping-pong amplification", "ping-pong derived piRNA", "secondary piRNA biogenesis", "secondary PIWI-associated RNA processing" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0034587" ]
[]
[]
[]
[ "GO:0034587" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23135\" xsd:anyURI" ]
null
2022-12-12T13:25:26Z
false
true
5
GO:0140966
140,966
piRNA-mediated heterochromatin formation
biological_process
The formation of heterochromatin into a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process mediated by a Piwi-associated RNA (piRNA).
[ "PMID:23329111" ]
null
[ "piRNA-directed heterochromatin formation", "piwiRNA-directed heterochromatin formation" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0031048" ]
[]
[]
[]
[ "GO:0031048" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23135\" xsd:anyURI" ]
pg
2022-12-12T13:51:08Z
false
true
7
GO:0140967
140,967
manganese import into cell
biological_process
The directed movement of mangnanese ions from outside of a cell into a cell.
[ "PMID:22773749" ]
null
[ "manganese influx" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0071421", "GO:0098659" ]
[]
[]
[]
[ "GO:0071421", "GO:0098659" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24565\" xsd:anyURI" ]
pg
2022-12-13T10:31:49Z
false
true
2
GO:0140968
140,968
polyspecific organic cation:proton antiporter activity
molecular_function
Enables the transfer of various organic cations in exchange for a proton, according to the reaction: H+(out) + organic cation(in) = H+(in) + organic cation(out). The transported substrates are usually toxic molecules, drugs and xenobiotics.
[ "PMID:17047166", "PMID:17509534" ]
null
[ "proton:polyspecific organic cation antiporter activity" ]
[ "RELATED" ]
[]
[]
[ "TC:2.A.66.1.20" ]
[ "GO:0015078", "GO:0015297" ]
[]
[]
[]
[ "GO:0015078", "GO:0015297" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24594\" xsd:anyURI" ]
pg
2022-12-16T16:22:41Z
false
true
5
GO:0140969
140,969
determination of lung left/right asymmetry
biological_process
Determination of the asymmetric location of the lungs with respect to the left and right halves of the organism.
[ "GOC:BHFL", "GOC:rl", "PMID:19944405", "PMID:20007846", "PMID:21131974" ]
null
[]
[]
[]
[]
[]
[ "GO:0007368" ]
[ "part_of GO:0007507" ]
[ "part_of" ]
[ "GO:0007507" ]
[ "GO:0007368", "GO:0007507" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/10899\" xsd:anyURI" ]
pg
2023-01-03T17:36:31Z
false
true
3
GO:0140970
140,970
AIM2 inflammasome complex assembly
biological_process
The aggregation, arrangement and bonding together of a set of components to form the AIM2 inflammasome complex.
[ "PMID:33467177" ]
null
[]
[]
[]
[]
[]
[ "GO:0065003" ]
[]
[]
[]
[ "GO:0065003" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24609\" xsd:anyURI" ]
pg
2023-01-04T05:10:26Z
false
true
1
GO:0140971
140,971
regulation of AIM2 inflammasome complex assembly
biological_process
Any process that modulates the frequency, rate or extent of AIM2 inflammasome complex assembly.
[ "PMID:33467177" ]
null
[]
[]
[]
[]
[]
[ "GO:0043254" ]
[ "part_of GO:0141085", "regulates GO:0140970" ]
[ "part_of", "regulates" ]
[ "GO:0141085", "GO:0140970" ]
[ "GO:0043254", "GO:0140970", "GO:0141085" ]
[ "GO:0065007", "regulates GO:0140970" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24609\" xsd:anyURI" ]
pg
2023-01-04T05:12:54Z
false
true
9
GO:0140972
140,972
negative regulation of AIM2 inflammasome complex assembly
biological_process
Any process that stops, prevents or reduces the frequency, rate or extent of AIM2 inflammasome complex assembly.
[ "PMID:33467177" ]
null
[]
[]
[]
[]
[]
[ "GO:0031333", "GO:0140971" ]
[ "negatively_regulates GO:0140970", "part_of GO:0141086" ]
[ "negatively_regulates", "part_of" ]
[ "GO:0140970", "GO:0141086" ]
[ "GO:0031333", "GO:0140970", "GO:0140971", "GO:0141086" ]
[ "GO:0065007", "negatively_regulates GO:0140970" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24609\" xsd:anyURI" ]
pg
2023-01-04T05:14:04Z
false
true
3
GO:0140973
140,973
positive regulation of AIM2 inflammasome complex assembly
biological_process
Any process that activates or increases the frequency, rate or extent of AIM2 inflammasome complex assembly.
[ "PMID:33467177" ]
null
[]
[]
[]
[]
[]
[ "GO:0031334", "GO:0140971" ]
[ "part_of GO:0141087", "positively_regulates GO:0140970" ]
[ "part_of", "positively_regulates" ]
[ "GO:0141087", "GO:0140970" ]
[ "GO:0031334", "GO:0140970", "GO:0140971", "GO:0141087" ]
[ "GO:0065007", "positively_regulates GO:0140970" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24609\" xsd:anyURI" ]
pg
2023-01-04T05:15:31Z
false
true
7
GO:0140975
140,975
disruption of cellular anatomical structure in another organism
biological_process
The disruption of a cellular component of another organism, leading to damage or temporary subversion of that structure. In some cases this can cause malfunctioning of the cells and death of the target organism.
[ "GOC:pg" ]
null
[ "disruption of cellular component of another organism" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0141060" ]
[]
[]
[]
[ "GO:0141060" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24072\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24127\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25514\" xsd:anyURI" ]
pg
2022-09-23T13:20:49Z
false
true
7
GO:0140976
140,976
host defense response against symbiont-mediated perturbation of plasma membrane integrity
biological_process
The cellular processes and signaling pathways by which a cell responds to disruption of the integrity of its plasma membrane by another organism. Some toxins produced by other organisms can form pores in membranes, or affect the membrane permeability.
[ "PMID:17234446", "PMID:21518219" ]
null
[ "defense response against disruption of plasma membrane integrity", "defense response against perturbation of plasma membrane integrity" ]
[ "EXACT", "RELATED" ]
[]
[]
[]
[ "GO:0140546" ]
[]
[]
[]
[ "GO:0140546" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24061\" xsd:anyURI" ]
pg
2022-09-23T13:28:52Z
false
true
1
GO:0140977
140,977
cellular detoxification of acetone
biological_process
Any process carried out at the cellular level that reduces or removes the toxicity of acetone. These may include chemical modification, for example to methylglyoxal.
[ "PMID:22314896", "PMID:26958851" ]
null
[]
[]
[]
[]
[]
[ "GO:1990748" ]
[]
[]
[]
[ "GO:1990748" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24645\" xsd:anyURI" ]
pg
2023-01-06T17:49:55Z
false
true
6
GO:0140978
140,978
mitochondrial large ribosomal subunit binding
molecular_function
Binding to a mitochondrial large ribosomal subunit.
[ "PMID:28892042" ]
null
[ "mitochondrial ribosomal large subunit binding" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0043023", "GO:0097177" ]
[]
[]
[]
[ "GO:0043023", "GO:0097177" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24488\" xsd:anyURI" ]
pg
2023-01-10T09:20:15Z
false
true
4
GO:0140979
140,979
intracellular nucleotide homeostasis
biological_process
A homeostatic process involved in the maintenance of a steady state level of nucleotides within a cell.
[ "PMID:23416111", "PMID:34880500" ]
null
[]
[]
[]
[]
[]
[ "GO:0055082" ]
[]
[]
[]
[ "GO:0055082" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24665\" xsd:anyURI" ]
pg
2023-01-10T14:13:19Z
false
true
5
GO:0140980
140,980
intracellular nucleoside homeostasis
biological_process
A homeostatic process involved in the maintenance of a steady state level of nucleosides within a cell.
[ "PMID:23416111", "PMID:34880500" ]
null
[]
[]
[]
[]
[]
[ "GO:0055082" ]
[]
[]
[]
[ "GO:0055082" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24665\" xsd:anyURI" ]
pg
2023-01-10T14:14:42Z
false
true
1
GO:0140981
140,981
medium-chain fatty acid omega-hydroxylase activity
molecular_function
Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.
[ "RHEA:75279" ]
While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
[]
[]
[]
[]
[ "MetaCyc:RXN-19719", "RHEA:38947", "RHEA:75279", "RHEA:75283" ]
[ "GO:0120250" ]
[]
[]
[]
[ "GO:0120250" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch RHEA:75279", "skos:narrowMatch RHEA:38947", "skos:narrowMatch RHEA:75283", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24661\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26445\" xsd:anyURI", "term_tracker_item \"https:/...
pg
2023-01-10T14:42:33Z
false
true
6
GO:0140982
140,982
detoxification of aluminum ion
biological_process
Any process that reduce or remove the toxicity of aluminum ions. These can include transport of the aluminum away from sensitive areas, sequesteration, or chemical modification to an inert form.
[ "PMID:10845450", "PMID:23888867", "PMID:9576769" ]
null
[ "aluminum ion homeostasis" ]
[ "RELATED" ]
[]
[]
[]
[ "GO:0061687" ]
[]
[]
[]
[ "GO:0061687" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24667\" xsd:anyURI" ]
pg
2023-01-11T07:32:59Z
false
true
4
GO:0140983
140,983
calcium:manganese antiporter activity
molecular_function
Catalysis of the reaction: Ca2+(in) + Mn2+(out) = Ca2+(out) + Mn2+(in).
[ "PMID:30755481" ]
null
[ "manganese:calcium antiporter activity" ]
[ "EXACT" ]
[]
[]
[ "RHEA:73059" ]
[ "GO:0005384", "GO:0015368" ]
[]
[]
[]
[ "GO:0005384", "GO:0015368" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch RHEA:73059", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24683\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
pg
2023-01-11T15:15:37Z
false
true
3
GO:0140984
140,984
histone H4K12 methyltransferase activity
molecular_function
Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 12) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 12). This reaction is the addition of a methyl group to the lysine residue at position 12 of the histone H4 protein.
[ "PMID:12086618" ]
Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
[ "histone H4 lysine 12-specific methyltransferase activity", "histone H4K12 methylase activity", "histone H4K12 methylation", "histone lysine N-methyltransferase activity (H4-K12 specific)", "histone methylase activity (H4-K12 specific)", "histone methyltransferase activity (H4-K12 specific)", "histone-H...
[ "EXACT", "BROAD", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0016279", "GO:0140939" ]
[]
[]
[]
[ "GO:0016279", "GO:0140939" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24695\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]
pg
2023-01-12T13:58:00Z
false
true
4
GO:0140985
140,985
G protein-coupled chemorepellent receptor activity
molecular_function
Combining with a chemorepellent and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
[ "PMID:30462573" ]
null
[ "G protein chemorepellent receptor activity", "G-protein chemorepellent receptor activity", "G-protein coupled chemorepellent receptor activity" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0004930" ]
[]
[]
[]
[ "GO:0004930" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24672\" xsd:anyURI" ]
pg
2023-01-24T15:50:07Z
false
true
8
GO:0140986
140,986
G protein-coupled chemorepellent receptor signaling pathway
biological_process
A G protein-coupled receptor signaling pathway initiated by a chemorepellent binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. cytoskeleton reorganization.
[ "PMID:30462573" ]
null
[]
[]
[]
[]
[]
[ "GO:0007186" ]
[]
[]
[]
[ "GO:0007186" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24672\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26425\" xsd:anyURI" ]
pg
2023-01-24T15:55:42Z
false
true
4
GO:0140987
140,987
ATP:phosphate antiporter activity
molecular_function
Enables the transfer of ATP from one side of a membrane to the other according to the reaction: ATP(out) + phosphate(in) = ATP(in) + phosphate(out).
[ "PMID:15123600" ]
null
[ "ATP:inorganic phosphate antiporter activity", "inorganic phosphate:ATP antiporter activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[ "RHEA:65840" ]
[ "GO:0005347", "GO:0015315" ]
[]
[]
[]
[ "GO:0005347", "GO:0015315" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch RHEA:65840", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24780\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
pg
2023-01-26T12:51:22Z
false
true
3
GO:0140989
140,989
7-deoxyloganate 7-hydroxylase activity
molecular_function
Catalysis of the reaction: 7-deoxyloganate + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O + loganate + oxidized [NADPH-hemoprotein reductase].
[ "PMID:24710322", "RHEA:57576" ]
null
[]
[]
[]
[]
[ "RHEA:57576" ]
[ "GO:0016712" ]
[]
[]
[]
[ "GO:0016712" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:1.14.14.85", "skos:exactMatch RHEA:57576", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24838\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
pg
2023-02-01T09:58:39Z
false
true
7
GO:0140990
140,990
primary piRNA processing
biological_process
The process involved in converting precursor piRNAs into non-overlapping, contiguous primary piRNAs (approximately 24-30-nt piRNAs with a preference for a 5' uridine (U) via the endonucleolytic activity of cytosolic PIWI. This may include pre-piRNA maturation of 3' ends by trimming and 2'-O-methylation.
[ "PMID:22907665", "PMID:26166577", "PMID:34469728" ]
null
[]
[]
[]
[]
[]
[ "GO:0034587" ]
[]
[]
[]
[ "GO:0034587" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23135\" xsd:anyURI" ]
pg
2023-02-01T13:36:56Z
false
true
2
GO:0140991
140,991
piRNA-mediated gene silencing by mRNA destabilization
biological_process
A cytoplasmic post-transcriptional gene silencing pathway in which piRNAs direct the cleavage of target mRNAs. The target mRNA, often transcribed from a transposable element, is destabilized by the activity of a PIWI class endonuclease within the piRNA-induced silencing complex. This may also be accompanied by mRNA dea...
[ "PMID:29281264", "PMID:33419460" ]
null
[]
[]
[]
[]
[]
[ "GO:0035194", "GO:0061157" ]
[]
[]
[]
[ "GO:0035194", "GO:0061157" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23135\" xsd:anyURI" ]
pg
2023-02-01T13:56:48Z
false
true
5
GO:0140993
140,993
histone modifying activity
molecular_function
A catalytic activity that acts on a histone protein. Reversible histone modifications contribute to regulation of gene expression.
[ "GOC:pg" ]
null
[]
[]
[]
[]
[]
[ "GO:0140096" ]
[ "part_of GO:0006338" ]
[ "part_of" ]
[ "GO:0006338" ]
[ "GO:0006338", "GO:0140096" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24980\" xsd:anyURI" ]
pg
2023-02-22T13:33:01Z
false
true
7
GO:0140994
140,994
RNA polymerase II CTD heptapeptide repeat modifying activity
molecular_function
A catalytic activity that acts on the RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS). Reversible modifications cof the RNA polymerase II CTD repeats contribute to regulation of RNA polymerase activity.
[ "GOC:pg" ]
null
[ "RNA polymerase II CTD repeat modifying activity", "RNA polymerase II large subunit CTD heptapeptide repeat modifying activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0140096" ]
[ "part_of GO:0006357" ]
[ "part_of" ]
[ "GO:0006357" ]
[ "GO:0006357", "GO:0140096" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24910\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24980\" xsd:anyURI" ]
pg
2023-02-22T13:37:21Z
false
true
8
GO:0140995
140,995
histone H2A kinase activity
molecular_function
Catalysis of the transfer of a phosphate group to a histone H2A.
[ "PMID:25303536" ]
null
[]
[]
[]
[]
[]
[ "GO:0035173" ]
[]
[]
[]
[ "GO:0035173" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24999\" xsd:anyURI" ]
pg
2023-02-24T12:08:10Z
false
true
9
GO:0140996
140,996
histone H3 kinase activity
molecular_function
Catalysis of the transfer of a phosphate group to a histone H3.
[ "PMID:25303536" ]
null
[]
[]
[]
[]
[]
[ "GO:0035173" ]
[]
[]
[]
[ "GO:0035173" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24999\" xsd:anyURI" ]
pg
2023-02-24T12:11:12Z
false
true
2
GO:0140997
140,997
histone H4 kinase activity
molecular_function
Catalysis of the transfer of a phosphate group to a histone H4.
[ "PMID:25303536" ]
null
[]
[]
[]
[]
[]
[ "GO:0035173" ]
[]
[]
[]
[ "GO:0035173" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24999\" xsd:anyURI" ]
pg
2023-02-24T12:11:49Z
false
true
2
GO:0140998
140,998
histone H2B kinase activity
molecular_function
Catalysis of the transfer of a phosphate group to a histone H2B.
[ "PMID:25303536" ]
null
[]
[]
[]
[]
[]
[ "GO:0035173" ]
[]
[]
[]
[ "GO:0035173" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24999\" xsd:anyURI" ]
pg
2023-02-24T12:14:43Z
false
true
1
GO:0140999
140,999
histone H3K4 trimethyltransferase activity
molecular_function
Catalysis of the reaction: L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3.
[ "PMID:18375658", "RHEA:60260" ]
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary acro...
[ "histone H3-K4 trimethylation", "histone H3K4 trimethylase activity", "histone H3K4 trimethylation", "histone lysine N-trimethyltransferase activity (H3-K4 specific)" ]
[ "BROAD", "EXACT", "BROAD", "EXACT" ]
[]
[]
[ "EC:2.1.1.354", "RHEA:60260" ]
[ "GO:0042800" ]
[]
[]
[]
[ "GO:0042800" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.1.1.354", "skos:exactMatch RHEA:60260", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22588\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-onto...
pg
2023-02-28T12:52:48Z
false
true
2
GO:0141000
141,000
histone H4K91 ubiquitin ligase activity
molecular_function
Catalysis of the transfer of a ubiquitin molecule to histone 4 at the lysine-91 residue.
[ "PMID:19818714" ]
Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
[ "histone H4-K91 ubiquitin ligase activity", "histone ubiquitin ligase activity (H4-K91 specific)" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0141056" ]
[]
[]
[]
[ "GO:0141056" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24861\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]
pg
2023-02-28T13:00:50Z
false
true
7
GO:0141002
141,002
histone H4K16 propionyltransferase activity
molecular_function
Catalysis of the reaction: histone H4 L-lysine (position 16) + propionyl-CoA = CoA + H+ + histone H3 N6-propionyl-L-lysyl (position 16).
[ "PMID:17267393", "PMID:29321206", "PMID:31794431" ]
Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
[]
[]
[]
[]
[]
[ "GO:0061922" ]
[]
[]
[]
[ "GO:0061922" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch RHEA:54020", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23791\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30578\" xsd:anyURI" ]
pg
2023-02-28T13:42:40Z
false
true
7
GO:0141003
141,003
histone H2AX kinase activity
molecular_function
Catalysis of the transfer of a phosphate group to a histone variant H2AX.
[ "GOC:bf" ]
null
[]
[]
[]
[]
[]
[ "GO:0035173" ]
[]
[]
[]
[ "GO:0035173" ]
[]
[]
[]
[]
[]
[]
pg
2023-02-28T13:55:39Z
false
true
4
GO:0141006
141,006
transposable element silencing by piRNA-mediated heterochromatin formation
biological_process
A transposable element silencing mechanism in which a Piwi-associated RNA (piRNA) triggers heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription.
[ "PMID:32381626", "PMID:32674113" ]
null
[ "piRNA-mediated retrotransposon silencing by heterochromatin formation" ]
[ "NARROW" ]
[]
[]
[ "Reactome:R-HSA-9845323 \"Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)\"" ]
[ "GO:0140966", "GO:0141005" ]
[]
[]
[]
[ "GO:0140966", "GO:0141005" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25029\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28924\" xsd:anyURI" ]
pg
2023-03-01T12:11:52Z
false
true
3
GO:0141007
141,007
transposable element silencing by siRNA-mediated heterochromatin formation
biological_process
A transposable element silencing mechanism in which a siRNA triggers heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription.
[ "PMID:36570931" ]
null
[ "siRNA-mediated retrotransposon silencing by heterochromatin formation" ]
[ "NARROW" ]
[]
[]
[]
[ "GO:0141005", "GO:0141194" ]
[]
[]
[]
[ "GO:0141005", "GO:0141194" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25029\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28924\" xsd:anyURI" ]
pg
2023-03-01T12:12:18Z
false
true
7
GO:0141008
141,008
transposable element silencing by mRNA destabilization
biological_process
A transposable element silencing mechanism in which mRNAs transcribed from transposons are targeted for degradation.
[ "GOC:curators" ]
null
[ "post-transcriptional retrotransposon silencing", "retrotransposon silencing by mRNA destabilization" ]
[ "EXACT", "NARROW" ]
[]
[]
[]
[ "GO:0010526", "GO:0061157" ]
[]
[]
[]
[ "GO:0010526", "GO:0061157" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25029\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25222\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28360\" xsd:anyURI", "term_tracker_item \"https://gi...
pg
2023-03-01T12:12:56Z
false
true
1
GO:0141009
141,009
transposable element silencing by piRNA-mediated mRNA destabilization
biological_process
A transposable element silencing mechanism in which mRNAs transcribed from transposons are targeted for degradation by a Piwi-associated RNA (piRNA).
[ "PMID:22121019" ]
null
[ "piRNA-mediated post-transcriptional retrotransposon silencing", "piRNA-mediated retrotransposon silencing by mRNA destabilization" ]
[ "EXACT", "NARROW" ]
[]
[]
[]
[ "GO:0140991", "GO:0141008" ]
[]
[]
[]
[ "GO:0140991", "GO:0141008" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25029\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25222\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28924\" xsd:anyURI" ]
pg
2023-03-01T12:13:49Z
false
true
2
GO:0141010
141,010
transposable element silencing by siRNA-mediated DNA methylation
biological_process
A transposable element silencing mechanism mediated by RNA-directed DNA methylation. RNA-directed DNA methylation is a gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. ...
[ "PMID:28633017", "PMID:32381626", "PMID:32719317", "PMID:36570931" ]
null
[ "retrostransposon silencing by RdDM", "retrotransposon silencing by RNA-directed DNA methylation", "retrotransposon silencing by siRNA-directed DNA methylation", "transposable element silencing by siRNA-directed DNA methylation" ]
[ "EXACT", "RELATED", "NARROW", "EXACT" ]
[]
[]
[]
[ "GO:0080188", "GO:0141005" ]
[]
[]
[]
[ "GO:0080188", "GO:0141005" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25029\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27238\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28924\" xsd:anyURI" ]
pg
2023-03-01T12:15:34Z
false
true
8
GO:0141011
141,011
transposable element silencing by siRNA-mediated mRNA destabilization
biological_process
A transposable element silencing mechanism in which mRNAs transcribed from transposons are targeted for degradation by a siRNA.
[ "PMID:36570931" ]
null
[ "siRNA-mediated post-transcriptional retrotransposon silencing", "siRNA-mediated retrotransposon silencing by mRNA destabilization" ]
[ "EXACT", "NARROW" ]
[]
[]
[]
[ "GO:0141008" ]
[]
[]
[]
[ "GO:0141008" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25029\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25222\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28924\" xsd:anyURI" ]
pg
2023-03-01T12:53:36Z
false
true
8
GO:0141014
141,014
ribosome hibernation
biological_process
A cellular process that results in the silencing of ribosomes in quiescent cells. Quiescence takes place when cells encounter unfavorable conditions and cease to grow in bacteria and yeast. It also takes place in some specialized cells in higher eukaryotes, such as eggs. Ribosomes in a hibernation state are kept silent...
[ "PMID:28468753", "PMID:30177741", "PMID:36653451" ]
null
[]
[]
[]
[]
[]
[ "GO:0017148" ]
[]
[]
[]
[ "GO:0017148" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25082\" xsd:anyURI" ]
pg
2023-03-07T09:56:14Z
false
true
9
GO:0141016
141,016
G/T mismatch-specific thymine-DNA glycosylase activity
molecular_function
Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine and leaving an apyrimidinic (AP) site.
[ "EC:3.2.2.29", "PMID:12711670" ]
null
[]
[]
[]
[]
[ "EC:3.2.2.29" ]
[ "GO:0008263" ]
[]
[]
[]
[ "GO:0008263" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:3.2.2.29", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25053\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
pg
2023-03-24T15:23:09Z
false
true
2
GO:0141017
141,017
effector-mediated induction of cell cycle reactivation in host
biological_process
A symbiont process in which a molecule secreted by the symbiont reactivates the host cell cycle, resulting in DNA synthesis and host cell division, and contributing to vegetative tumor formation.
[ "PMID:25888589" ]
null
[]
[]
[]
[]
[]
[ "GO:0140418" ]
[ "part_of GO:0051819" ]
[ "part_of" ]
[ "GO:0051819" ]
[ "GO:0051819", "GO:0140418" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24370\" xsd:anyURI" ]
pg
2023-04-04T08:41:31Z
false
true
9
GO:0141018
141,018
adhesion of symbiont to host via host extracellular matrix
biological_process
The attachment of a symbiont to its host by binding to a component of the host extracellular matrix. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:15228540", "PMID:21270401", "PMID:23586629" ]
null
[ "adhesion of symbiont to host extracellular matrix via collagen", "adhesion of symbiont to host extracellular matrix via fibronectin", "adhesion of symbiont to host extracellular matrix via integrin", "adhesion of symbiont to host extracellular matrix via laminin", "adhesion of symbiont to host extracellula...
[ "NARROW", "NARROW", "NARROW", "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0044406" ]
[]
[]
[]
[ "GO:0044406" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25169\" xsd:anyURI" ]
pg
2023-04-06T09:23:37Z
false
true
6
GO:0141023
141,023
symbiont-mediated disruption of host cell-cell adhesion
biological_process
A process in which a symbiont alters or subverts host cell adhesion ito its extracellular matrix. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "GOC:curators" ]
null
[ "disruption by symbiont of host cell-cell adhesion" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0044068" ]
[]
[]
[]
[ "GO:0044068" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25172\" xsd:anyURI" ]
pg
2023-04-06T09:29:32Z
false
true
3
GO:0141024
141,024
adhesion of symbiont to host cell surface via host membrane carbohydrate
biological_process
The attachment of a symbiont to its host by binding to a carbohydrate on the host cell surface. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:15210807", "PMID:19527885", "PMID:30736336" ]
null
[]
[]
[]
[]
[]
[ "GO:0044650" ]
[]
[]
[]
[ "GO:0044650" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25169\" xsd:anyURI" ]
pg
2023-04-06T09:30:33Z
false
true
7
GO:0141025
141,025
adhesion of symbiont to host cell surface via host glycoprotein
biological_process
The attachment of a symbiont to its host by binding to a glycoprotein on the host cell surface. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:12010488", "PMID:15487949", "PMID:17630833", "PMID:29184850" ]
null
[]
[]
[]
[]
[]
[ "GO:0044650" ]
[]
[]
[]
[ "GO:0044650" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25169\" xsd:anyURI" ]
pg
2023-04-06T09:31:43Z
false
true
3
GO:0141026
141,026
adhesion of symbiont to host cell surface via host membrane cholesterol
biological_process
The attachment of a symbiont to its host by binding to cholesterol on the host cell surface. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:17557817", "PMID:23239883" ]
null
[]
[]
[]
[]
[]
[ "GO:0044650" ]
[]
[]
[]
[ "GO:0044650" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25169\" xsd:anyURI" ]
pg
2023-04-06T09:32:28Z
false
true
3
GO:0141027
141,027
symbiont-mediated perturbation of host actin cytoskeleton
biological_process
The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:20688909" ]
null
[ "disruption by symbiont of actin cytoskeleton", "modification by symbiont of host actin cytoskeleton", "perturbation by symbiont of host actin cytoskeleton" ]
[ "RELATED", "RELATED", "EXACT" ]
[]
[]
[]
[ "GO:0052039" ]
[]
[]
[]
[ "GO:0052039" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25183\" xsd:anyURI" ]
pg
2023-04-06T11:28:16Z
false
true
1
GO:0141028
141,028
symbiont-mediated perturbation of host microtubule cytoskeleton
biological_process
The process in which an organism effects a change that impairs the structure or function of the host microtubule cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:21692747", "PMID:26220855" ]
null
[ "disruption by symbiont of host microtubule cytoskeleton", "modification by symbiont of host microtubule cytoskeleton", "perturbation by symbiont of host microtubule cytoskeleton" ]
[ "RELATED", "RELATED", "EXACT" ]
[]
[]
[]
[ "GO:0052039" ]
[]
[]
[]
[ "GO:0052039" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25183\" xsd:anyURI" ]
pg
2023-04-06T11:30:03Z
false
true
3
GO:0141030
141,030
symbiont-mediated perturbation of host actin cytoskeleton via filamentous actin depolymerization
biological_process
The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by depolymerizing the host filamentous actin. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:11889090", "PMID:28800062" ]
null
[]
[]
[]
[]
[]
[ "GO:0141027" ]
[]
[]
[]
[ "GO:0141027" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25183\" xsd:anyURI" ]
pg
2023-04-06T11:34:08Z
false
true
7
GO:0141031
141,031
symbiont-mediated perturbation of host actin cytoskeleton via actin crosslinking
biological_process
The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by actin crosslinking the host actin filaments. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:14512630", "PMID:22814176" ]
null
[ "perturbation by symbiont of host actin cytoskeleton via actin crosslinking" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0141027" ]
[]
[]
[]
[ "GO:0141027" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25183\" xsd:anyURI" ]
pg
2023-04-06T11:37:14Z
false
true
9
GO:0141032
141,032
symbiont-mediated perturbation of host actin cytoskeleton via actin filament reorganization
biological_process
The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by reorganizing the actin filaments, in a way that keeps the total filementous actin remains approximately constant. The host is defined as the larger of the organisms involved in a symbiotic interact...
[ "PMID:22212282", "PMID:31130928" ]
null
[ "perturbation by symbiont of host actin cytoskeleton via actin filament rearrangement", "perturbation by symbiont of host actin cytoskeleton via actin filament reorganization" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0141027" ]
[]
[]
[]
[ "GO:0141027" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25183\" xsd:anyURI" ]
pg
2023-04-06T11:40:17Z
false
true
1
GO:0141033
141,033
symbiont-mediated perturbation of host actin cytoskeleton via actin polymerization
biological_process
The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by polymerizing the host filamentous actin. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:18331467", "PMID:25293534" ]
null
[ "perturbation by symbiont of host actin cytoskeleton via actin polymerization" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0141027" ]
[]
[]
[]
[ "GO:0141027" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25183\" xsd:anyURI" ]
pg
2023-04-06T11:42:55Z
false
true
6
GO:0141034
141,034
symbiont-mediated perturbation of host actin cytoskeleton via inhibition of actin polymerization
biological_process
The process in which an organism effects a change that disrupts the host actin cytoskeleton by inhibiting host actin from polymerizing. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:23409096", "PMID:24253566", "PMID:30297616" ]
null
[ "perturbation by symbiont of host actin cytoskeleton via inhibition of actin polymerization" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0141027" ]
[]
[]
[]
[ "GO:0141027" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25183\" xsd:anyURI" ]
pg
2023-04-06T11:43:27Z
false
true
7
GO:0141035
141,035
CTP-dependent diacylglycerol kinase activity
molecular_function
Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + CTP = a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H+.
[ "RHEA:25948" ]
null
[ "DAG kinase activity", "diacylglycerol kinase (CTP dependent)", "diacylglycerol kinase activity", "diacylglycerol kinase activity (CTP)" ]
[ "BROAD", "BROAD", "BROAD", "EXACT" ]
[]
[]
[ "EC:2.7.1.174", "KEGG_REACTION:R09944", "MetaCyc:RXN-12959", "RHEA:25948" ]
[ "GO:0001727", "GO:0016773" ]
[]
[]
[]
[ "GO:0001727", "GO:0016773" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.7.1.174", "skos:exactMatch RHEA:25948", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25280\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
pg
2023-04-18T07:14:42Z
false
true
1
GO:0141038
141,038
phosphatidylinositol 3-kinase activator activity
molecular_function
Binds to and increases the activity of a phosphatidylinositol 3-kinase (PI3K).
[ "PMID:31686003" ]
null
[]
[]
[]
[]
[]
[ "GO:0035014" ]
[]
[]
[]
[ "GO:0035014" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25382\" xsd:anyURI" ]
pg
2023-05-16T15:05:30Z
false
true
6
GO:0141039
141,039
phosphatidylinositol 3-kinase inhibitor activity
molecular_function
Binds to and decreases the activity of a phosphatidylinositol 3-kinase (PI3K).
[ "PMID:31686003" ]
null
[]
[]
[]
[]
[]
[ "GO:0035014" ]
[]
[]
[]
[ "GO:0035014" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25382\" xsd:anyURI" ]
pg
2023-05-16T15:06:32Z
false
true
2
GO:0141040
141,040
very-long-chain 3-oxoacyl-CoA reductase activity
molecular_function
Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + H+ + NADPH. This reaction is the second (reduction) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit.
[ "PMID:16564093", "PMID:19763486", "RHEA:48680" ]
null
[]
[]
[]
[]
[ "EC:1.1.1.330", "MetaCyc:RXN-7698", "Reactome:R-HSA-548818 \"HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA\"", "RHEA:39267", "RHEA:48680", "RHEA:85831" ]
[ "GO:0016616" ]
[]
[]
[]
[ "GO:0016616" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.1.1.330", "skos:exactMatch RHEA:48680", "skos:narrowMatch RHEA:39267", "skos:narrowMatch RHEA:85831", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25302\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25805\" xsd:anyUR...
pg
2023-05-17T11:30:31Z
false
true
6
GO:0141041
141,041
obsolete disruption of extracellular matrix of another organism
biological_process
OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of the extracellular matrix of another organism.
[ "PMID:2817904" ]
This term was obsoleted because it represents an unnecessary grouping term, as this process can occur during host-symbiont interactions or be mediated by toxin secreted by free-living organisms.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25393\" xsd:anyURI" ]
pg
2023-05-17T13:43:30Z
true
true
7
GO:0141042
141,042
symbiont-mediated cAMP intoxication of host cell
biological_process
The production by a symbiont of high levels of cyclic AMP in a host cell, impairing host cellular functions in multiple ways, including ATP depletion, interference with host intracellular signaling, cytoskeletal defects and apoptosis-related cell death. The host is defined as the larger of the organisms involved in a s...
[ "PMID:16390441", "PMID:19516256", "PMID:27731909", "PMID:33013916" ]
null
[ "cAMP intoxication in host" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0052027" ]
[]
[]
[]
[ "GO:0052027" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25439\" xsd:anyURI" ]
pg
2023-05-24T14:21:25Z
false
true
1
GO:0141043
141,043
symbiont-mediated evasion of host innate immune response
biological_process
A process by which a symbiont avoids recognition by host's innate immune response by altering, concealing or destroying a conserved symbiont molecule recognized by the host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:15014080", "PMID:22131330", "PMID:26502908", "PMID:29101229" ]
null
[ "evasion of host innate immune recognition", "evasion of host innate immune response" ]
[ "RELATED", "EXACT" ]
[]
[]
[]
[ "GO:0042783" ]
[]
[]
[]
[ "GO:0042783" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25442\" xsd:anyURI" ]
pg
2023-05-24T14:50:14Z
false
true
6
GO:0141044
141,044
epigenetic programming in the endosperm
biological_process
The global programming of epigenetic modifications following binucleate central cell fertilization. This involves DNA methylation at the silent allele. In the endosperm, maternal genomes are hypomethylated compared with the paternal genome.
[ "PMID:10580004", "PMID:16469697", "PMID:16527743", "PMID:18700816", "PMID:28118754" ]
null
[ "epigenetic reprogramming in the endosperm" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0044725" ]
[]
[]
[]
[ "GO:0044725" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25455\" xsd:anyURI" ]
pg
2023-05-26T13:22:06Z
false
true
4
GO:0141046
141,046
Atg8-family conjugating enzyme activity
molecular_function
Isoenergetic transfer of an Atg8 family modifier from one protein to a phosphatidylethanolamine or phosphatidylserine on a membrane, via the reaction X-Atg8 + Y = Y-Atg8 + X.
[ "PMID:11100732", "PMID:17986448", "PMID:18704115", "PMID:28234446", "PMID:33909989" ]
null
[ "APG8 conjugating enzyme activity", "Atg8 conjugating enzyme activity", "Atg8-like conjugating activity", "E2" ]
[ "EXACT", "NARROW", "EXACT", "BROAD" ]
[]
[]
[]
[ "GO:0061650" ]
[]
[]
[]
[ "GO:0061650" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17675\" xsd:anyURI" ]
pg
2023-06-05T10:10:22Z
false
true
6
GO:0141047
141,047
molecular tag activity
molecular_function
A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another molecule (for example a protein or a lipid) where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport ...
[ "PMID:17632063" ]
Use this term to annotate conjugated tags, not for conjugating enzymes. At the time of writing, all known gene products with this activity are ubiquitin-like, either based on overall sequence similarity or the presence of common motifs and structures.
[ "covalent modifier", "tag" ]
[ "BROAD", "EXACT" ]
[]
[]
[]
[ "GO:0003674" ]
[]
[]
[]
[ "GO:0003674" ]
[]
[]
[]
[]
[]
[]
pg
2023-06-05T12:45:06Z
false
true
7
GO:0141048
141,048
membrane tag activity
molecular_function
A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to a lipid, where it acts as a marker for a membrane, recognized by the cellular apparatus to target the tagged protein for some cellular process such as autophagy.
[ "PMID:17632063" ]
Use this term to annotate conjugated tags, not for conjugating enzymes. At the time of writing, all known gene products with this activity are ubiquitin-like, either based on overall sequence similarity or the presence of common motifs and structures.
[ "covalent modifier", "lipid tag" ]
[ "BROAD", "EXACT" ]
[]
[]
[]
[ "GO:0141047" ]
[]
[]
[]
[ "GO:0141047" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25472\" xsd:anyURI" ]
pg
2023-06-05T12:50:02Z
false
true
3
GO:0141049
141,049
protein-glutathione oxidoreductase (glutathione) activity
molecular_function
Catalysis of the reaction: glutathionylated protein (PSSG) + glutathione (GSH) = protein-thiol (PSH) + glutathione disulfide (GSSG). The reaction may proceed via a 'monothiol' or 'dithiol' mechanism.
[ "PMID:23397885", "PMID:33932870", "PMID:36771108" ]
null
[ "glutaredoxin activity", "glutathione oxidoreductase activity" ]
[ "BROAD", "BROAD" ]
[]
[]
[]
[ "GO:0015036", "GO:0016671", "GO:0140096" ]
[]
[]
[]
[ "GO:0015036", "GO:0016671", "GO:0140096" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25498\" xsd:anyURI" ]
pg
2023-06-07T06:36:33Z
false
true
9
GO:0141050
141,050
histone H3K deacetylase activity
molecular_function
Removal of an acetyl group from a lysine residue in a histone H3.
[ "GOC:pg", "PMID:9893272" ]
Histone deacytylase (HDAC) enzymes are divided into four classes: the Class I Rpd3-like proteins (in human: HDAC1, HDAC2, HDAC3, and HDAC8); the Class II Hda1-like proteins (in human: HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10); the Class III Sir2-like proteins (in human: SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, an...
[]
[]
[]
[]
[]
[ "GO:0004407" ]
[]
[]
[]
[ "GO:0004407" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.3.1.-", "skos:broadMatch EC:3.5.1.-", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22836\" xsd:anyURI" ]
pg
2024-09-20T11:40:05Z
false
true
5
GO:0141051
141,051
histone H4K deacetylase activity
molecular_function
Removal of an acetyl group from a lysine residue in a histone H4.
[ "PMID:12590135" ]
Histone deacytylase (HDAC) enzymes are divided into four classes: the Class I Rpd3-like proteins (in human: HDAC1, HDAC2, HDAC3, and HDAC8); the Class II Hda1-like proteins (in human: HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10); the Class III Sir2-like proteins (in human: SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, an...
[]
[]
[]
[]
[]
[ "GO:0004407" ]
[]
[]
[]
[ "GO:0004407" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.3.1.-", "skos:broadMatch EC:3.5.1.-", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25508\" xsd:anyURI" ]
pg
2023-06-07T09:15:53Z
false
true
2
GO:0141052
141,052
histone H3 demethylase activity
molecular_function
Catalysis of the removal of a methyl group from a modified lysine residue of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
[ "PMID:17947579" ]
null
[]
[]
[]
[]
[]
[ "GO:0032452" ]
[]
[]
[]
[ "GO:0032452" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25508\" xsd:anyURI" ]
pg
2023-06-07T09:22:57Z
false
true
2
GO:0141053
141,053
histone H2A ubiquitin ligase activity
molecular_function
Catalysis of the transfer of ubiquitin to a histone H2A substrate.
[ "PMID:25303536" ]
null
[]
[]
[]
[]
[]
[ "GO:0140852" ]
[]
[]
[]
[ "GO:0140852" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25508\" xsd:anyURI" ]
pg
2023-06-07T09:27:23Z
false
true
2
GO:0141055
141,055
histone H3 ubiquitin ligase activity
molecular_function
Catalysis of the transfer of ubiquitin to a histone H3 substrate.
[ "PMID:25303536" ]
null
[]
[]
[]
[]
[]
[ "GO:0140852" ]
[]
[]
[]
[ "GO:0140852" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25508\" xsd:anyURI" ]
pg
2023-06-07T09:33:34Z
false
true
7
GO:0141057
141,057
histone H3 arginine deiminase activity
molecular_function
Catalysis of the reaction: H2O + histone H3 L-arginyl = histone H3 L-citrullyl + NH4+, resulting in histone H3 citrullination.
[ "PMID:25303536" ]
null
[]
[]
[]
[]
[]
[ "GO:0140794" ]
[]
[]
[]
[ "GO:0140794" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25508\" xsd:anyURI" ]
pg
2023-06-07T09:35:46Z
false
true
3