Datasets:
LiteFold
/
GO

Dataset card Data Studio Files
xet
 Community
go_id
string
go_numeric_id
int64
name
string
namespace
string
definition
string
definition_xrefs
list
comment
string
synonyms
list
synonym_scopes
list
alt_ids
list
subsets
list
xrefs
list
is_a_ids
list
relationship_edges
list
relationship_types
list
relationship_target_ids
list
parent_ids
list
intersection_of
list
union_of
list
disjoint_from
list
replaced_by
list
consider
list
property_values
list
created_by
string
creation_date
string
is_obsolete
bool
in_go_basic
bool
split_bucket
int64
GO:0141058
141,058
histone H4 demethylase activity
molecular_function
Catalysis of the removal of a methyl group from a modified lysine residue of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
[ "PMID:17947579" ]
null
[]
[]
[]
[]
[]
[ "GO:0032452" ]
[]
[]
[]
[ "GO:0032452" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25508\" xsd:anyURI" ]
pg
2023-06-07T09:47:52Z
false
true
3
GO:0141059
141,059
symbiont-mediated disruption of host antimicrobial peptide activity
biological_process
Any process in which a symbiont interferes with a host antimicrobial peptide, for example by cleavage or degradation.
[ "PMID:16242332", "PMID:19015361", "PMID:21335044" ]
null
[ "disruption of host antimicrobial peptide activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0044414" ]
[]
[]
[]
[ "GO:0044414" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25513\" xsd:anyURI" ]
pg
2023-06-07T14:08:47Z
false
true
2
GO:0141061
141,061
disruption of cell in another organism
biological_process
The disruption of a cell of another organism, leading to damage or temporary subversion of that cell.
[ "GOC:pg" ]
null
[]
[]
[]
[]
[]
[ "GO:0141060" ]
[]
[]
[]
[ "GO:0141060" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25514\" xsd:anyURI" ]
pg
2023-06-07T14:41:21Z
false
true
8
GO:0141063
141,063
epigenetic programming in the central cell
biological_process
The establishment of epigenetic modifications (imprints) in a plant central cell, leading to an asymmetry between the two maternal alleles and the paternal allele, and differential expression of the corresponding alleles in the developing endosperm. This can happen through heterochromatin formation or differential chro...
[ "PMID:28118754" ]
null
[]
[]
[]
[]
[]
[ "GO:0071514" ]
[]
[]
[]
[ "GO:0071514" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25455\" xsd:anyURI" ]
pg
2023-06-09T12:27:08Z
false
true
3
GO:0141064
141,064
zygotic genome activation
biological_process
A process that contributes to the onset of de novo transcription from the zygotic genome as part of the maternal-to-zygote transition in gene expression. The zygote overcomes the silencing that has been established. The cause of this silencing could be due to several factors: chromatin modifications leading to repressi...
[ "PMID:19204068", "PMID:20808952" ]
null
[ "ZGA" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0010628" ]
[ "part_of GO:0160021" ]
[ "part_of" ]
[ "GO:0160021" ]
[ "GO:0010628", "GO:0160021" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23918\" xsd:anyURI" ]
pg
2023-06-09T14:42:09Z
false
true
9
GO:0141065
141,065
maternal mRNA clearance
biological_process
The chemical reactions and pathways resulting in the clearance of maternal mRNA transcripts from the zygote as part of the maternal-to-zygote transition in gene expression.
[ "PMID:19204068", "PMID:32558204" ]
null
[ "maternal mRNA degradation", "maternal transcript clearance", "maternal transcript degradation" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0006402" ]
[ "part_of GO:0160021" ]
[ "part_of" ]
[ "GO:0160021" ]
[ "GO:0006402", "GO:0160021" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23918\" xsd:anyURI" ]
pg
2023-06-09T14:50:39Z
false
true
6
GO:0141066
141,066
symbiont-mediated disruption of host extracellular matrix
biological_process
The process in which an organism effects a change that impairs the structure or function of the host extracellular matrix.
[ "PMID:11982763", "PMID:21115719", "PMID:2404867", "PMID:25865874" ]
null
[ "disruption of host extracellular matrix" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0052008" ]
[]
[]
[]
[ "GO:0052008" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25514\" xsd:anyURI" ]
pg
2023-06-14T13:51:30Z
false
true
3
GO:0141067
141,067
intracellular nitrogen homeostasis
biological_process
A homeostatic process involved in the maintenance of a steady state level of nitrogen within a cell.
[ "GOC:tb" ]
null
[ "cellular nitrogen homeostasis", "nitrogen homeostasis" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0055082" ]
[]
[]
[]
[ "GO:0055082" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25558\" xsd:anyURI" ]
pg
2023-06-15T08:56:16Z
false
true
7
GO:0141068
141,068
autosome genomic imprinting
biological_process
The establishment of epigenetic modifications (imprints) in autosomal (non-sexual) chromosomes during gametogenesis, and propagation of these imprints during the organism's life. Genomic imprinting leads to an asymmetry between the maternal and paternal alleles and differential expression of the corresponding alleles. ...
[ "PMID:31782494" ]
null
[ "autosomal genomic imprinting", "genomic imprinting of autosomal genes" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0071514" ]
[]
[]
[]
[ "GO:0071514" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25563\" xsd:anyURI" ]
pg
2023-06-16T13:21:42Z
false
true
2
GO:0141069
141,069
receptor ligand inhibitor activity
molecular_function
Binds to and decreases the activity of the ligand of a signaling receptor.
[ "PMID:12478285", "PMID:1721860" ]
null
[ "signaling receptor ligand inhibitor activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0140678" ]
[ "negatively_regulates GO:0048018" ]
[ "negatively_regulates" ]
[ "GO:0048018" ]
[ "GO:0048018", "GO:0140678" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25538\" xsd:anyURI" ]
pg
2023-06-19T09:43:30Z
false
true
2
GO:0141070
141,070
symbiont-mediated suppression of host MAPK cascade
biological_process
A process in which a symbiont interferes with, inhibits or disrupts a MAPK signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:18005697" ]
null
[ "disruption of host MAP kinase signaling pathway", "disruption of host MAPK signal transduction pathway", "disruption of host MAPK signaling pathway", "symbiont-mediated suppression of host MAPK signal transduction pathway" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0052029", "GO:0052080" ]
[]
[]
[]
[ "GO:0052029", "GO:0052080" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25572\" xsd:anyURI" ]
pg
2023-06-19T13:29:24Z
false
true
8
GO:0141071
141,071
symbiont-mediated activation of host MAPK cascade
biological_process
A process in which a symbiont subverts a MAPK signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:24043761", "PMID:25675415", "PMID:28166272" ]
null
[ "activation by symbiont of host MAPK signal transduction pathway", "induction by symbiont of host MAP kinase signal transduction pathway", "induction of host MAPK kinase signaling pathway", "stimulation by symbiont of host MAPK signal transduction pathway", "symbiont-mediated activation of host MAPK signal ...
[ "NARROW", "EXACT", "EXACT", "NARROW", "EXACT" ]
[]
[]
[]
[ "GO:0052028", "GO:0052080" ]
[]
[]
[]
[ "GO:0052028", "GO:0052080" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25572\" xsd:anyURI" ]
pg
2023-06-19T13:32:28Z
false
true
2
GO:0141072
141,072
symbiont-mediated suppression of host tumor necrosis factor-mediated signaling pathway
biological_process
A process in which a virus interferes with, inhibits or disrupts a tumor necrosis factor-mediated signal transduction in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:11805081", "PMID:24736233" ]
null
[ "disruption of host TNF-mediated signaling pathway", "disruption of host TNFR-mediated signaling pathway", "disruption of host tumor necrosis factor receptor-mediated signaling pathway", "disruption of host tumor necrosis factor-mediated signaling pathway" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0052029" ]
[]
[]
[]
[ "GO:0052029" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25580\" xsd:anyURI" ]
pg
2023-06-21T14:26:53Z
false
true
2
GO:0141073
141,073
symbiont-mediated perturbation of host opsonization
biological_process
A process in which a symbiont alters or subverts opsonization by the host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:18068388", "PMID:18941224", "PMID:2307127", "PMID:28860090" ]
null
[ "disruption by symbiont of host opsonization" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0052031" ]
[]
[]
[]
[ "GO:0052031" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25616\" xsd:anyURI" ]
pg
2023-06-26T14:46:24Z
false
true
6
GO:0141075
141,075
obsolete suppression of host JAK-STAT cascade
biological_process
OBSOLETE. A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:20624917", "PMID:22919663", "PMID:27437422", "PMID:29924996", "PMID:31413201" ]
This term was obsoleted because it represents the same process as symbiont-mediated suppression of host JAK-STAT cascade ; GO:0039514.
[ "disruption of host JAK-STAT cascade", "down-regulation of host JAK-STAT cascade", "downregulation of host JAK-STAT cascade", "inhibition of host JAK-STAT cascade", "negative regulation of host JAK-STAT cascade", "suppression of host JAK-STAT cascade", "symbiont-mediated suppression of host JAK-STAT cas...
[ "EXACT", "EXACT", "EXACT", "NARROW", "EXACT", "EXACT", "RELATED" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0039514" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25581\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26686\" xsd:anyURI" ]
pg
2023-06-28T11:01:14Z
true
true
2
GO:0141076
141,076
obsolete suppression of host TRAF-mediated signal transduction
biological_process
OBSOLETE. A process in which a symbiont interferes with, inhibits or disrupts a TRAF-mediated signal transduction in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:20335533", "PMID:22407319", "PMID:31311877" ]
This term was obsoleted because it was redundant with symbiont-mediated suppression of host TRAF-mediated signal transduction ; GO:0039527.
[ "disruption of host TRAF-mediated signal transduction", "inhibition of host TRAF-mediated signal transduction", "inhibition of host TRAFs", "negative regulation of host TRAF-mediated signal transduction", "suppression of host TRAF activity", "suppression of host TRAF-mediated signal transduction", "supp...
[ "EXACT", "EXACT", "NARROW", "EXACT", "NARROW", "EXACT", "EXACT", "RELATED" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25581\" xsd:anyURI" ]
pg
2023-06-28T11:10:32Z
true
true
8
GO:0141077
141,077
obsolete suppression of host interferon-mediated signaling pathway
biological_process
OBSOLETE. A process in which a symbiont interferes with, inhibits or disrupts an interferon-mediated signaling in the host organism.
[ "PMID:31266861", "PMID:34305858" ]
This term was obsoleted because it represents the same concept as suppression of host interferon-mediated signaling pathway ; GO:0140886.
[ "inhibition of host interferon signaling pathway", "negative regulation of host interferon-mediated signaling pathway", "suppression of host IFN-mediated signaling pathway", "suppression of host interferon-mediated signaling pathway", "symbiont-mediated of host interferon-mediated signaling pathway" ]
[ "RELATED", "EXACT", "EXACT", "NARROW", "RELATED" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0140886" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25581\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26686\" xsd:anyURI" ]
pg
2023-06-28T11:19:12Z
true
true
2
GO:0141078
141,078
obsolete symbiont-mediated suppression of host RIG-I signaling pathway
biological_process
OBSOLETE. A process in which a symbiont interferes with, inhibits or disrupts a RIG-I signaling pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:19936053" ]
This term was obsoleted because it was created by mistake; it represents the same process as symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity ; GO:0039540.
[ "disruption of host RIG-1 signaling pathway", "disruption of host RIG-I signaling pathway" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0039540" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25581\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28234\" xsd:anyURI" ]
pg
2023-07-05T13:42:08Z
true
true
3
GO:0141079
141,079
symbiont-mediated activation of host inflammasome-mediated signal transduction
biological_process
A process in which a symbiont subverts an inflammasome-mediated signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:25538194", "PMID:28331908", "PMID:30872531", "PMID:34155776" ]
null
[ "perturbation of host inflammasome-mediated signal transduction" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0052028" ]
[]
[]
[]
[ "GO:0052028" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25685\" xsd:anyURI" ]
pg
2023-07-05T14:20:19Z
false
true
6
GO:0141080
141,080
symbiont-mediated activation of host interferon signaling pathway
biological_process
A process in which a symbiont subverts an interferon-mediated signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation.
[ "PMID:26553469", "PMID:29076073" ]
null
[]
[]
[]
[]
[]
[ "GO:0052028" ]
[]
[]
[]
[ "GO:0052028" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25686\" xsd:anyURI" ]
pg
2023-07-05T14:38:51Z
false
true
6
GO:0141081
141,081
symbiont-mediated suppression of host inflammasome-mediated signal transduction
biological_process
A process in which a symbiont interferes with, inhibits or stops an inflammasome-mediated signal transduction pathway in the host organism by interfering with its normal execution. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:26687278", "PMID:27214553", "PMID:29061850", "PMID:34324582", "PMID:36227980" ]
null
[ "perturbation of host inflammasome-mediated signal transduction" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0039537" ]
[]
[]
[]
[ "GO:0039537" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25685\" xsd:anyURI" ]
pg
2023-07-10T14:20:22Z
false
true
7
GO:0141082
141,082
symbiont-mediated detoxification of host-generated reactive oxygen species
biological_process
A process in which a symbiont interferes with, inhibits or disrupts the host reactive oxygen species (ROS)-mediated innate immune response by directly degrading host ROS. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:19684141", "PMID:27825304", "PMID:28288207" ]
null
[]
[]
[]
[]
[ "Reactome:R-HSA-1222538 \"Tolerance by Mtb to nitric oxide produced by macrophages\"" ]
[ "GO:0052164" ]
[]
[]
[]
[ "GO:0052164" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25714\" xsd:anyURI" ]
pg
2023-07-12T14:04:04Z
false
true
9
GO:0141083
141,083
symbiont-mediated suppression of host reactive oxygen species generation
biological_process
A process in which a symbiont interferes with, inhibits or disrupts the host signal transduction pathways leading to the production of reactive oxygen species as part of the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:27473656", "PMID:31375544" ]
null
[ "inhibition by organism of defense-related host active oxygen species production" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0044068", "GO:0052031" ]
[]
[]
[]
[ "GO:0044068", "GO:0052031" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25714\" xsd:anyURI" ]
pg
2023-07-12T14:21:06Z
false
true
2
GO:0141084
141,084
inflammasome-mediated signaling pathway
biological_process
An intracellular signal transduction pathway that starts with a ligand binding to a pattern recognition receptor (PRR), assembly of the inflammasome complex, leading to the activation of CASP1 and inducing an inflammatory response. In some cases, inflammasome-mediated signal transduction can lead to programmed cell dea...
[ "PMID:35883561" ]
null
[ "inflammasome-mediated signal transduction" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0002753" ]
[ "part_of GO:0006954" ]
[ "part_of" ]
[ "GO:0006954" ]
[ "GO:0002753", "GO:0006954" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25772\" xsd:anyURI" ]
pg
2023-07-18T12:28:03Z
false
true
1
GO:0141085
141,085
regulation of inflammasome-mediated signaling pathway
biological_process
Any process that modulates the frequency, rate or extent of an inflammasome-mediated signaling pathway.
[ "PMID:33467177" ]
null
[ "regulation of inflammasome-mediated signal transduction" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0039531" ]
[ "regulates GO:0141084" ]
[ "regulates" ]
[ "GO:0141084" ]
[ "GO:0039531", "GO:0141084" ]
[ "GO:0065007", "regulates GO:0141084" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25772\" xsd:anyURI" ]
pg
2023-07-18T12:37:42Z
false
true
7
GO:0141086
141,086
negative regulation of inflammasome-mediated signaling pathway
biological_process
Any process that stops, prevents or reduces the frequency, rate or extent of an inflammasome-mediated signaling pathway.
[ "PMID:33467177" ]
null
[ "negative regulation of inflammasome-mediated signal transduction" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0039532", "GO:0141085" ]
[ "negatively_regulates GO:0141084" ]
[ "negatively_regulates" ]
[ "GO:0141084" ]
[ "GO:0039532", "GO:0141084", "GO:0141085" ]
[ "GO:0065007", "negatively_regulates GO:0141084" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25772\" xsd:anyURI" ]
pg
2023-07-18T12:40:09Z
false
true
5
GO:0141087
141,087
positive regulation of inflammasome-mediated signaling pathway
biological_process
Any process that activates or increases the frequency, rate or extent of an inflammasome-mediated signaling pathway.
[ "PMID:33467177" ]
null
[ "positive regulation of inflammasome-mediated signal transduction" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0062208", "GO:0141085", "GO:1902533" ]
[ "positively_regulates GO:0141084" ]
[ "positively_regulates" ]
[ "GO:0141084" ]
[ "GO:0062208", "GO:0141084", "GO:0141085", "GO:1902533" ]
[ "GO:0065007", "positively_regulates GO:0141084" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25772\" xsd:anyURI" ]
pg
2023-07-18T12:40:21Z
false
true
1
GO:0141088
141,088
obsolete symbiont-mediated activation of host autophagy
biological_process
OBSOLETE. A process in which a symbiont initiates, promotes, or enhances the activation of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "GOC:pg" ]
This term was obsoleted because it represents the same process as symbiont-mediated activation of host autophagy ; GO:0039520.
[ "induction of host autophagy", "positive regulation by symbiont of host autophagy" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0039520" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17055\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28790\" xsd:anyURI" ]
pg
2023-07-19T14:39:06Z
true
true
3
GO:0141089
141,089
glucose sensor activity
molecular_function
Binding to and responding, e.g. by conformational change, to changes in the cellular level of glucose.
[ "PMID:17470517" ]
null
[ "glucose sensing activity" ]
[ "EXACT" ]
[]
[]
[ "Reactome:R-HSA-170810 \"nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR)\"" ]
[ "GO:0140299" ]
[ "has_part GO:0005536" ]
[ "has_part" ]
[ "GO:0005536" ]
[ "GO:0005536", "GO:0140299" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25267\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25792\" xsd:anyURI" ]
pg
2023-07-24T13:39:21Z
false
true
6
GO:0141090
141,090
protein serine pyrophosphorylase activity
molecular_function
Catalysis of the reaction: protein phospho-serine + inositol 5-triphosphate pentakisphosphate = protein diphospho-serine + inositol 5-diphosphate pentakisphosphate.
[ "PMID:36603579", "RHEA:64104" ]
null
[ "protein serine pyrophosphatase activity" ]
[ "RELATED" ]
[]
[]
[ "RHEA:64104" ]
[ "GO:0016776" ]
[]
[]
[]
[ "GO:0016776" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch RHEA:64104", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25934\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
pg
2023-08-21T07:53:21Z
false
true
5
GO:0141091
141,091
transforming growth factor beta receptor superfamily signaling pathway
biological_process
The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription.
[ "PMID:22651914", "PMID:28096268" ]
null
[ "TGF-beta receptor superfamily signaling pathway", "TGF-beta receptor superfamily signalling pathway", "TGFbeta receptor superfamily signaling pathway", "TGFbeta receptor superfamily signalling pathway", "transforming growth factor beta receptor superfamily signalling pathway" ]
[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0007178" ]
[]
[]
[]
[ "GO:0007178" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23449\" xsd:anyURI" ]
pg
2023-08-30T05:48:29Z
false
true
7
GO:0141093
141,093
5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase activity
molecular_function
Catalysis of the reaction: 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H+ + L-methionine.
[ "PMID:11948155", "PMID:23072415", "PMID:25781338", "RHEA:55200" ]
null
[]
[]
[]
[]
[ "EC:2.5.1.147", "MetaCyc:RXN-19229", "RHEA:55200" ]
[ "GO:0016765" ]
[]
[]
[]
[ "GO:0016765" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.5.1.147", "skos:exactMatch RHEA:55200", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25983\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
pg
2023-09-07T11:46:06Z
false
true
8
GO:0141094
141,094
DNA loop anchor binding
molecular_function
Binding to a DNA loop anchor, a region of chromosome that defines the ends of a DNA loop where two parts of same DNA strand are held in close physical proximity. For example, in animals, the anchors of DNA loops are convergently oriented CTCF binding sites during interphase.
[ "PMID:25497547", "PMID:26499245" ]
null
[]
[]
[]
[]
[]
[ "GO:0043565" ]
[]
[]
[]
[ "GO:0043565" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26069\" xsd:anyURI" ]
pg
2023-09-08T11:43:21Z
false
true
6
GO:0141095
141,095
obsolete retrotransposon silencing by DNA methylation-dependent heterochromatin formation
biological_process
OBSOLETE. A retrotransposon silencing mechanism in which a methylated cytosine residues in the genome promote heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription.
[ "PMID:15318244" ]
This term was obsoleted because it represent the same pathway as retrotransposon silencing by siRNA-directed DNA methylation ; GO:0141010.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0141010" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25029\" xsd:anyURI" ]
pg
2023-09-08T14:05:16Z
true
true
2
GO:0141096
141,096
ligand-modulated transcription repressor activity
molecular_function
A DNA-binding transcription repressor activity regulated by binding to a ligand and that inhibits the transcription of specific genes and gene sets.
[ "PMID:21555518" ]
null
[ "ligand-activated transcription repressor activity" ]
[ "NARROW" ]
[]
[]
[]
[ "GO:0001217", "GO:0098531" ]
[]
[]
[]
[ "GO:0001217", "GO:0098531" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26077\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29176\" xsd:anyURI" ]
pg
2023-09-11T08:07:51Z
false
true
5
GO:0141097
141,097
ligand-modulated transcription activator activity
molecular_function
A DNA-binding transcription activator activity regulated by binding to a ligand and that activates the transcription of specific genes and gene sets.
[ "GOC:pg" ]
null
[ "ligand-activated transcription activator activity" ]
[ "NARROW" ]
[]
[]
[]
[ "GO:0001216", "GO:0098531" ]
[]
[]
[]
[ "GO:0001216", "GO:0098531" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26077\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29176\" xsd:anyURI" ]
pg
2023-09-11T08:11:03Z
false
true
3
GO:0141098
141,098
tRNA (cytidine(34)-2'-O-ribose)-methyltransferase activity
molecular_function
Catalysis of the reaction: cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H+ + S-adenosyl-L-homocysteine.
[ "PMID:31943105", "RHEA:43084" ]
null
[ "tRNA (cytidine 34-2'-O)-methyltransferase activity", "tRNA (cytidine(34)-2'-O)-methyltransferase activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[ "MetaCyc:RXN-11860", "RHEA:43084" ]
[ "GO:0016427" ]
[]
[]
[]
[ "GO:0016427" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.1.1.207", "skos:exactMatch MetaCyc:RXN-11860", "skos:exactMatch RHEA:43084", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26084\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30714\" xsd:anyURI" ]
pg
2023-09-11T13:53:59Z
false
true
4
GO:0141102
141,102
tRNA (5-carboxymethylaminomethyluridine(34)-2'-O-ribose)-methyltransferase activity
molecular_function
Catalysis of the reaction: 5-carboxymethylaminomethyluridine34 in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine34 in tRNA(Leu) + H+ + S-adenosyl-L-homocysteine.
[ "PMID:20855540", "RHEA:43088" ]
null
[ "tRNA (5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase activity", "tRNA (cytidine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase activity" ]
[ "EXACT", "EXACT" ]
[]
[]
[ "RHEA:43088" ]
[ "GO:0016300" ]
[]
[]
[]
[ "GO:0016300" ]
[]
[]
[]
[]
[]
[ "skos:broadMatch EC:2.1.1.207", "skos:exactMatch RHEA:43088", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26145\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
pg
2023-09-19T10:47:21Z
false
true
6
GO:0141104
141,104
symbiont-mediated activation of host G protein-coupled receptor signal transduction
biological_process
A process in which a symbiont initiates, promotes, or enhances a G protein-coupled receptor signal transduction pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:15963708", "PMID:18978047", "PMID:25332123" ]
null
[]
[]
[]
[]
[]
[ "GO:0052028", "GO:0075118" ]
[]
[]
[]
[ "GO:0052028", "GO:0075118" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26164\" xsd:anyURI" ]
pg
2023-09-27T14:13:43Z
false
true
7
GO:0141105
141,105
obsolete suppression of host toll-like receptor signal transduction
biological_process
OBSOLETE. A process in which a symbiont interferes with, inhibits or disrupts a toll-like receptor signaling pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:15944308", "PMID:17299722", "PMID:18327267" ]
This term was obsoleted because it represents the same process as symbiont-mediated suppression of host toll-like receptor signal transduction ; GO:0039722.
[ "symbiont-mediated disruption of host toll-like receptor signaling pathway", "symbiont-mediated suppression of host toll-like receptor signal transduction", "symbiont-mediated suppression of host toll-like receptor signaling pathway" ]
[ "EXACT", "RELATED", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0039722" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26183\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26686\" xsd:anyURI" ]
pg
2023-09-27T14:37:00Z
true
true
7
GO:0141106
141,106
tRNA methyltransferase activator activity
molecular_function
Binds to and increases the activity of a methyltransferase.
[ "GOC:curators" ]
null
[]
[]
[]
[]
[]
[ "GO:0008047", "GO:0141107" ]
[ "positively_regulates GO:0008168" ]
[ "positively_regulates" ]
[ "GO:0008168" ]
[ "GO:0008047", "GO:0008168", "GO:0141107" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26266\" xsd:anyURI" ]
pg
2023-10-12T14:22:49Z
false
true
4
GO:0141107
141,107
methyltransferase regulator activity
molecular_function
Binds to and modulates the activity of a methyltransferase.
[ "PMID:15899842", "PMID:34669960" ]
null
[]
[]
[]
[]
[]
[ "GO:0030234" ]
[ "regulates GO:0008168" ]
[ "regulates" ]
[ "GO:0008168" ]
[ "GO:0008168", "GO:0030234" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26266\" xsd:anyURI" ]
pg
2023-10-12T14:22:49Z
false
true
2
GO:0141108
141,108
transporter regulator activity
molecular_function
Binds to and modulates the activity of a transporter.
[ "GOC:curators" ]
null
[]
[]
[]
[]
[]
[ "GO:0098772" ]
[ "regulates GO:0005215" ]
[ "regulates" ]
[ "GO:0005215" ]
[ "GO:0005215", "GO:0098772" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26268\" xsd:anyURI" ]
pg
2023-10-12T14:38:38Z
false
true
2
GO:0141109
141,109
transporter activator activity
molecular_function
Binds to and increases the activity of a transporter.
[ "GOC:curators" ]
null
[]
[]
[]
[]
[]
[ "GO:0140677", "GO:0141108" ]
[ "positively_regulates GO:0005215" ]
[ "positively_regulates" ]
[ "GO:0005215" ]
[ "GO:0005215", "GO:0140677", "GO:0141108" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26268\" xsd:anyURI" ]
pg
2023-10-12T14:38:38Z
false
true
7
GO:0141111
141,111
positive regulation of cGAS/STING signaling pathway
biological_process
Any process that activates or increases the frequency, rate or extent of of cGAS/STING signaling pathway.
[ "PMID:37802025" ]
null
[]
[]
[]
[]
[]
[ "GO:0039531", "GO:0062208", "GO:1902533" ]
[ "positively_regulates GO:0140896" ]
[ "positively_regulates" ]
[ "GO:0140896" ]
[ "GO:0039531", "GO:0062208", "GO:0140896", "GO:1902533" ]
[ "GO:0065007", "positively_regulates GO:0140896" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26301\" xsd:anyURI" ]
pg
2023-10-23T15:27:08Z
false
true
5
GO:0141112
141,112
broken chromosome clustering
biological_process
The process of bringing together chromosomes fragments resulting from DNA damage. Broken chromosome tethering during mitosis ensures clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss and enhancing genome integrity.
[ "PMID:37165191", "PMID:37316668" ]
null
[]
[]
[]
[]
[]
[ "GO:0051276" ]
[ "part_of GO:0006974" ]
[ "part_of" ]
[ "GO:0006974" ]
[ "GO:0006974", "GO:0051276" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26156\" xsd:anyURI" ]
pg
2023-10-31T12:21:09Z
false
true
6
GO:0141113
141,113
negative regulation of Wnt signaling pathway, planar cell polarity pathway
biological_process
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway, planar cell polarity pathway.
[ "PMID:19056682" ]
null
[]
[]
[]
[]
[]
[ "GO:2000051", "GO:2000095" ]
[ "negatively_regulates GO:0060071" ]
[ "negatively_regulates" ]
[ "GO:0060071" ]
[ "GO:0060071", "GO:2000051", "GO:2000095" ]
[ "GO:0065007", "negatively_regulates GO:0060071" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26394\" xsd:anyURI" ]
pg
2023-11-10T10:33:34Z
false
true
1
GO:0141114
141,114
obsolete symbiont-mediated suppression of host complement activation
biological_process
OBSOLETE. A process by which a symbiont inhibits or disrupts the normal execution of the activation of complement in its host.
[ "PMID:20194595", "PMID:25830295" ]
This term was obsoleted because it represents the same process as GO:0042784.
[ "suppression of complement activation by another organism" ]
[ "BROAD" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0042784" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26389\" xsd:anyURI" ]
pg
2023-11-22T15:22:34Z
true
true
6
GO:0141115
141,115
symbiont-mediated suppression of host complement activation by inactivation of complement proteins
biological_process
A process by which a symbiont disrupts or prematurely activates host complement so that its microbial-destroying activities fail.
[ "PMID:24312361", "PMID:34305859" ]
null
[ "suppression of complement activation by another organism by inactivation of complement proteins" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0042784" ]
[]
[]
[]
[ "GO:0042784" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26389\" xsd:anyURI" ]
pg
2023-11-22T15:32:58Z
false
true
6
GO:0141116
141,116
symbiont-mediated suppression of host complement activation by complement sequestering
biological_process
A process by which a symbiont prevents host complement activation by sequestering it away from its surface.
[ "PMID:18323455" ]
null
[ "suppression of complement activation by another organism by complement sequestering" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0042784" ]
[]
[]
[]
[ "GO:0042784" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26389\" xsd:anyURI" ]
pg
2023-11-22T15:34:16Z
false
true
1
GO:0141117
141,117
symbiont-mediated suppression of host complement activation by recruitment of complement control protein
biological_process
A process by which a symbiont prevents the activation of host complement by binding a soluble complement control protein (CCP) of the host and recruiting it to the microbe surface. The normal role of CCPs is to prevent complement activation on 'self' cellular targets. When soluble CCPs are recuited to the surface of a ...
[ "PMID:17513779", "PMID:22540535", "PMID:24129254", "PMID:27304426" ]
null
[ "suppression of complement activation by another organism by recruitment of complement control protein", "suppression of complement activation by another organism by recuitement of complement control protein" ]
[ "BROAD", "EXACT" ]
[]
[]
[]
[ "GO:0042784" ]
[]
[]
[]
[ "GO:0042784" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26389\" xsd:anyURI" ]
pg
2023-11-22T15:35:52Z
false
true
5
GO:0141122
141,122
nitrogen-oxygen lyase activity
molecular_function
Catalysis of the breakage of a nitrogen-oxygen bond by means other than hydrolysis and oxidation.
[ "EC:4.8.1.-" ]
null
[]
[]
[]
[]
[ "EC:4.8.1.-" ]
[ "GO:0016829" ]
[]
[]
[]
[ "GO:0016829" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:4.8.1.-", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24927\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30699\" xsd:anyURI" ]
pg
2023-12-01T13:17:35Z
false
true
4
GO:0141124
141,124
intracellular signaling cassette
biological_process
An intracellular signaling module that is part of larger signaling pathways that can be initiated either intracellularly or by cell surface receptors. Intracellular signaling cassettes are discrete signaling units that are often shared by multiple signaling pathways.
[ "GOC:ha", "GOC:pg" ]
null
[ "intracellular signaling cascade", "intracellular signaling module" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0035556" ]
[]
[]
[]
[ "GO:0035556" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26557\" xsd:anyURI" ]
pg
2023-12-04T14:13:20Z
false
true
9
GO:0141125
141,125
tRNA-queuosine(34) galactosyltransferase activity
molecular_function
Catalysis of the reaction: queuosine34 in tRNA + UDP-alpha-D-galactose = H+ + O-5''-beta-D-galactosylqueuosine34 in tRNATyr + UDP. Substrates include tRNA(Tyr) and tRNA(Asp).
[ "PMID:37992713" ]
null
[ "tRNA queuosine galactosyltransferase activity", "tRNA queuosine(34) galactosyltransferase activity" ]
[ "BROAD", "EXACT" ]
[]
[]
[ "RHEA:78231" ]
[ "GO:0035250", "GO:0140101" ]
[]
[]
[]
[ "GO:0035250", "GO:0140101" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch RHEA:78231", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26593\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
pg
2023-12-08T08:08:35Z
false
true
3
GO:0141126
141,126
short-chain fatty acyl-CoA hydrolase activity
molecular_function
Catalysis of the reaction: a short-chain fatty acyl-CoA + H2O = a short fatty acid + CoA + H+. A short-chain fatty acid has an aliphatic tail of less than 6 carbons.
[ "RHEA:68180" ]
While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
[]
[]
[]
[]
[ "EC:3.1.2.18", "MetaCyc:3.1.2.18-RXN", "RHEA:31251", "RHEA:40103", "RHEA:40111", "RHEA:40799", "RHEA:45156", "RHEA:55052", "RHEA:55064", "RHEA:55084", "RHEA:55096", "RHEA:65204", "RHEA:65208", "RHEA:66980", "RHEA:66984", "RHEA:68180" ]
[ "GO:0047617" ]
[]
[]
[]
[ "GO:0047617" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch RHEA:68180", "skos:narrowMatch EC:3.1.2.18", "skos:narrowMatch RHEA:31251", "skos:narrowMatch RHEA:40103", "skos:narrowMatch RHEA:40111", "skos:narrowMatch RHEA:40799", "skos:narrowMatch RHEA:45156", "skos:narrowMatch RHEA:55052", "skos:narrowMatch RHEA:55064", "skos:narrowMatch R...
pg
2023-12-08T09:05:55Z
false
true
8
GO:0141127
141,127
symbiont-mediated perturbation of host Rab small GTPase signal transduction
biological_process
A process in which a symbiont alters a Rab protein family-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:24251537", "PMID:30181274", "PMID:30893609" ]
null
[ "modulation by symbiont of host Rab protein mediated signal transduction", "modulation by symbiont of host Rab protein signal transduction", "modulation by symbiont of host Rab protein-mediated signal transduction", "modulation of host Rab protein signal transduction by symbiont", "modulation of host Rab pr...
[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0044082" ]
[]
[]
[]
[ "GO:0044082" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26637\" xsd:anyURI" ]
pg
2023-12-13T15:10:26Z
false
true
1
GO:0141128
141,128
symbiont-mediated non-specific activation of host T-cells
biological_process
A process by which a symbiont superantigen elicits a strong immune response by activating a large number of T cells in a non-specific manner. Unlike conventional antigens, which activate T cells by interacting with specific receptors on the surface of these cells, superantigens can stimulate T cells by binding to regio...
[ "PMID:12679262", "PMID:17427250", "PMID:28880920" ]
null
[ "symbiont-mediated non-specific T-cell activation in host", "symbiont-mediated nonspecific activation of host T-cells" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0052553" ]
[]
[]
[]
[ "GO:0052553" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26638\" xsd:anyURI" ]
pg
2023-12-14T07:58:16Z
false
true
5
GO:0141129
141,129
symbiont-mediated suppression of host signal transduction pathway via antagonism of host cell surface receptor
biological_process
A process by which a symbiont alters or subverts a host cell surface receptor-mediated signal transduction pathway by binding to and inhibiting the receptor of the pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:10221874", "PMID:22714643" ]
null
[ "symbiont-mediated perturbation of host signal transduction pathway via antagonism of host cell surface receptor" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0052029" ]
[]
[]
[]
[ "GO:0052029" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26310\" xsd:anyURI" ]
pg
2023-12-14T12:16:15Z
false
true
7
GO:0141130
141,130
symbiont-mediated inactivation of host ribosome
biological_process
A process in which a symbiont inhibits or disrupts translation of mRNA into protein in its host by inactivating its ribosomes.
[ "PMID:1324134" ]
null
[ "symbiont-mediated host ribosome inactivation" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0039604" ]
[]
[]
[]
[ "GO:0039604" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26184\" xsd:anyURI" ]
pg
2023-12-14T12:22:56Z
false
true
3
GO:0141131
141,131
DNA N6-methyladenine demethylase activity
molecular_function
Catalysis of the reaction: 2-oxoglutarate + an N6-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate.
[ "RHEA:49524" ]
null
[ "DNA N(6)-methyladenine demethylase activity" ]
[ "EXACT" ]
[]
[]
[ "EC:1.14.11.51", "RHEA:49524" ]
[ "GO:0016706", "GO:0035514" ]
[]
[]
[]
[ "GO:0016706", "GO:0035514" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.14.11.51", "skos:exactMatch RHEA:49524", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26656\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29802\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ont...
pg
2023-12-15T15:38:23Z
false
true
9
GO:0141132
141,132
obsolete defense response to host
biological_process
OBSOLETE. Reactions triggered in response to the presence of a host that act to protect or prevent damage to the symbiont.
[ "GOC:curators" ]
This term was obsoleted because it represents an unnecessary grouping term.
[]
[]
[ "GO:0052264", "GO:0052348", "GO:0052369" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21260\" xsd:anyURI" ]
pg
2023-12-18T13:27:26Z
true
true
6
GO:0141133
141,133
diphthine methyl ester synthase activity
molecular_function
Catalysis of the reaction: 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H+ + 4 S-adenosyl-L-homocysteine.
[ "PMID:24739148", "RHEA:42652" ]
This activity is present in eukaryotes and is part of the biosynthetic pathway of diphthamide. Note that this is different from the archaeal enzyme, diphthine synthase activity ; GO:0004164 (EC:2.1.1.98), which performs only 3 methylations, producing diphthine.
[]
[]
[]
[]
[ "EC:2.1.1.314", "MetaCyc:RXN-15775", "Reactome:R-HSA-5358484 \"DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2\"", "RHEA:42652" ]
[ "GO:0008276", "GO:0008757" ]
[]
[]
[]
[ "GO:0008276", "GO:0008757" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:2.1.1.314", "skos:exactMatch RHEA:42652", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25281\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]
pg
2023-12-20T09:06:24Z
false
true
5
GO:0141134
141,134
symbiont-mediated activation of host signal transduction pathway via agonism of host cell surface receptor
biological_process
A process in which a symbiont subverts a signal transduction pathway in the host organism by binding to and enhancing the activation of the receptor of the pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:10221874", "PMID:18563600" ]
null
[ "symbiont-mediated perturbation of host signal transduction pathway via antagonism of host cell surface receptor" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0052028" ]
[]
[]
[]
[ "GO:0052028" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26310\" xsd:anyURI" ]
pg
2023-12-20T14:49:23Z
false
true
3
GO:0141135
141,135
symbiont-mediated suppression of host chemokine signal transduction pathway
biological_process
A process in which a symbiont interferes with, inhibits or disrupts a chemokine signaling pathway, a G protein-coupled receptor signal transduction pathway activated by a chemokine. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:16581912" ]
null
[]
[]
[]
[]
[]
[ "GO:0075120" ]
[]
[]
[]
[ "GO:0075120" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26683\" xsd:anyURI" ]
pg
2023-12-20T15:40:32Z
false
true
8
GO:0141137
141,137
positive regulation of gene expression, epigenetic
biological_process
An epigenetic process that increases gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA demethylation.
[ "PMID:36618446" ]
null
[ "activation of gene expression, epigenetic", "up regulation of gene expression, epigenetic", "up-regulation of gene expression, epigenetic", "upregulation of gene expression, epigenetic" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0010628", "GO:0040029" ]
[]
[]
[]
[ "GO:0010628", "GO:0040029" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26694\" xsd:anyURI" ]
pg
2023-12-22T13:13:03Z
false
true
3
GO:0141139
141,139
symbiont-mediated disruption of host mucosa
biological_process
The disruption of the host mucosa by a symbiont, leading to damage or temporary subversion of that tissue. The mucosa is a membrane that lines various cavities in the body of an organism and covers the surface of internal organs.
[ "PMID:22520462", "PMID:28598765", "PMID:28764997" ]
null
[]
[]
[]
[]
[]
[ "GO:0141146" ]
[]
[]
[]
[ "GO:0141146" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26745\" xsd:anyURI" ]
pg
2024-01-16T09:44:42Z
false
true
4
GO:0141140
141,140
symbiont-mediated suppression of host immunoglobulin-mediated immune response
biological_process
A process in which a symbiont interferes with, inhibits or disrupts the normal execution of the immunoglobulin-mediated immune response of the host organism. One common mechanism by which this happens is the direct inhibition of immunoglobulin activity, by direct binding or modification. The host is defined as the larg...
[ "PMID:18426869", "PMID:22256861", "PMID:24753590" ]
null
[ "symbiont-mediated suppression of host immunoglobulin activity" ]
[ "RELATED" ]
[]
[]
[]
[ "GO:0052562" ]
[]
[]
[]
[ "GO:0052562" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26740\" xsd:anyURI" ]
pg
2024-01-16T09:55:22Z
false
true
1
GO:0141141
141,141
symbiont-mediated evasion of recognition by host pattern recognition receptor
biological_process
A process by which a symbiont avoids recognition by host's innate immune response by altering or concealing a conserved molecule recognized by the host's cell surface and intracellular pattern recognition receptors, including Toll-like and NOD-like receptors. The host is defined as the larger of the organisms involved ...
[ "PMID:17215377", "PMID:26502908", "PMID:29101229" ]
Note that this term should be used when the symbiont in cases where the symbiont modifies its own molecules (proteins, DNA, RNA, lipids) to avoid recognition by the host. In cases where the symbiont directly inhibits a component of a host cytoplasmic receptor signaling pathway, consider annotating to evasion of symbio...
[ "evasion of symbiont recognition by host pattern recognition receptor" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0141043" ]
[]
[]
[]
[ "GO:0141043" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26743\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27250\" xsd:anyURI" ]
pg
2024-01-16T10:00:30Z
false
true
1
GO:0141142
141,142
symbiont-mediated migration across host tissue barrier
biological_process
A process in which a symbiont moves across a tissue barrier of the host to transports itself across an extracellular cellular matrix barrier or between the cells of a tissue. This involves the temporary or permanent breaching of the tissue barrier.
[ "PMID:19820089", "PMID:20188700", "PMID:26681776", "PMID:29120408" ]
null
[]
[]
[]
[]
[]
[ "GO:0044001" ]
[]
[]
[]
[ "GO:0044001" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26813\" xsd:anyURI" ]
pg
2024-01-17T15:32:41Z
false
true
5
GO:0141143
141,143
obsolete symbiont-mediated disruption of host cell adhesion to extracellular matrix
biological_process
OBSOLETE. A process in which a symbiont alters or subverts cell adhesion to the extracellular matrix in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:22534208", "PMID:30345086" ]
This term was obsoleted because it was created by mistake.
[ "disruption by symbiont of host cell adhesion to extracellular matrix" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0141146" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25172\" xsd:anyURI" ]
pg
2024-01-17T15:47:43Z
true
true
4
GO:0141144
141,144
symbiont-mediated disruption of host neutrophil extracellular traps
biological_process
A process in which a symbiont damages or impairs host neutrophil extracellular traps. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:16488875", "PMID:21231972", "PMID:25605868" ]
null
[ "symbiont-mediated perturbation of host neutrophil extracellular traps" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0052008" ]
[]
[]
[]
[ "GO:0052008" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26811\" xsd:anyURI" ]
pg
2024-01-24T06:22:48Z
false
true
2
GO:0141145
141,145
symbiont-mediated suppression of host neutrophil extracellular trap formation
biological_process
A process in which a symbiont inhibits or disrupts the formation of neutrophil extracellular traps by the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:30038902", "PMID:34108482" ]
null
[ "symbiont-mediated perturbation of host neutrophil extracellular trap formation", "symbiont-mediated suppression of host neutrophil extracellular traps formation" ]
[ "RELATED", "EXACT" ]
[]
[]
[]
[ "GO:0044068", "GO:0052031" ]
[]
[]
[]
[ "GO:0044068", "GO:0052031" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26811\" xsd:anyURI" ]
pg
2024-01-24T06:32:59Z
false
true
9
GO:0141146
141,146
symbiont-mediated disruption of host tissue
biological_process
The process in which an organism effects a change that impairs the structure or function of a host tissue. This can occur via the disruption of the extracellular matrix, or the detachment of cells from the extracellular matrix, or the dissociation of the cells composing that tissue. The host is defined as the larger of...
[ "PMID:11982763", "PMID:14651638", "PMID:26355030" ]
null
[ "cytopathogenic effect" ]
[ "RELATED" ]
[]
[]
[]
[ "GO:0052111" ]
[]
[]
[]
[ "GO:0052111" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26814\" xsd:anyURI" ]
pg
2024-01-24T15:36:58Z
false
true
9
GO:0141147
141,147
intracellularly calcium-gated channel activity
molecular_function
Enables the transmembrane transfer of a solute by a channel that opens when calcium ions bind on the intracellular side of the channel complex or one of its constituent parts.
[ "PMID:20929730", "PMID:23021213" ]
null
[]
[]
[]
[]
[]
[ "GO:0022834" ]
[]
[]
[]
[ "GO:0022834" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26781\" xsd:anyURI" ]
pg
2024-01-25T13:36:48Z
false
true
3
GO:0141148
141,148
enoyl-[acyl-carrier-protein] reductase (NADPH) activity
molecular_function
Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NADP+ = a (2E)-enoyl-[ACP] + H+ + NADPH.
[ "RHEA:22564" ]
This reaction completes each cycle of fatty acid elongation by catalyzing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl- carrier protein, in an NADPH-dependent manner. Note that EC has reactions describing the stereo-specificity of the reaction wit...
[]
[]
[]
[]
[ "EC:1.3.1.10", "EC:1.3.1.104", "EC:1.3.1.39", "MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN", "RHEA:22564", "RHEA:41812" ]
[ "GO:0016631" ]
[]
[]
[]
[ "GO:0016631" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.3.1.104", "skos:exactMatch MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN", "skos:exactMatch RHEA:22564", "skos:narrowMatch EC:1.3.1.10", "skos:narrowMatch EC:1.3.1.39", "skos:narrowMatch RHEA:41812", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25699\" xsd:anyURI", ...
pg
2024-01-29T11:56:59Z
false
true
6
GO:0141149
141,149
regulation of nitric oxide-cGMP mediated signal transduction
biological_process
Any process that modulates the rate, frequency or extent of nitric oxide-cGMP mediated signal transduction.
[ "PMID:35931019" ]
null
[]
[]
[]
[]
[]
[ "GO:0010749" ]
[ "regulates GO:0038060" ]
[ "regulates" ]
[ "GO:0038060" ]
[ "GO:0010749", "GO:0038060" ]
[ "GO:0065007", "regulates GO:0038060" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26663\" xsd:anyURI" ]
pg
2024-01-29T14:03:39Z
false
true
9
GO:0141150
141,150
positive regulation of nitric oxide-cGMP mediated signal transduction
biological_process
Any process that increases the rate, frequency or extent of nitric oxide-cGMP mediated signal transduction.
[ "PMID:14615391" ]
null
[]
[]
[]
[]
[]
[ "GO:0010750", "GO:0141149" ]
[ "positively_regulates GO:0038060" ]
[ "positively_regulates" ]
[ "GO:0038060" ]
[ "GO:0010750", "GO:0038060", "GO:0141149" ]
[ "GO:0065007", "positively_regulates GO:0038060" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26663\" xsd:anyURI" ]
pg
2024-01-29T14:03:54Z
false
true
5
GO:0141151
141,151
negative regulation of nitric oxide-cGMP mediated signal transduction
biological_process
Any process that decreases the rate, frequency or extent of nitric oxide-cGMP mediated signal transduction.
[ "PMID:35931019" ]
null
[]
[]
[]
[]
[]
[ "GO:0010751", "GO:0141149" ]
[ "negatively_regulates GO:0038060" ]
[ "negatively_regulates" ]
[ "GO:0038060" ]
[ "GO:0010751", "GO:0038060", "GO:0141149" ]
[ "GO:0065007", "negatively_regulates GO:0038060" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26663\" xsd:anyURI" ]
pg
2024-01-29T14:04:06Z
false
true
7
GO:0141152
141,152
glycerol-3-phosphate dehydrogenase (NAD+) activity
molecular_function
Catalysis of the reaction: NAD+ + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H+ + NADH.
[ "RHEA:11092" ]
null
[ "alpha-glycerol phosphate dehydrogenase (NAD) activity", "alpha-glycerophosphate dehydrogenase (NAD) activity", "glycerol 1-phosphate dehydrogenase activity", "glycerol phosphate dehydrogenase (NAD) activity", "glycerol-3-phosphate dehydrogenase (NAD) activity", "glycerol-3-phosphate dehydrogenase [NAD+] ...
[ "EXACT", "EXACT", "BROAD", "EXACT", "EXACT", "EXACT", "EXACT", "BROAD", "BROAD", "BROAD", "BROAD", "BROAD", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[ "EC:1.1.1.8", "KEGG_REACTION:R00842", "MetaCyc:1.1.1.8-RXN", "RHEA:11092" ]
[ "GO:0047952" ]
[]
[]
[]
[ "GO:0047952" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch EC:1.1.1.8", "skos:exactMatch RHEA:11092", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21790\" xsd:anyURI" ]
pg
2024-01-30T10:47:46Z
false
true
2
GO:0141153
141,153
glycerol-3-phosphate dehydrogenase (NADP+) activity
molecular_function
NADP+ + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H+ + NADPH.
[ "PMID:15557260", "RHEA:11096" ]
null
[ "glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity", "glycerol-3-phosphate dehydrogenase [NADP+] activity", "L-glycerol-3-phosphate:NADP oxidoreductase activity" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[ "KEGG_REACTION:R00844", "RHEA:11096" ]
[ "GO:0047952" ]
[]
[]
[]
[ "GO:0047952" ]
[]
[]
[]
[]
[]
[ "skos:exactMatch RHEA:11096", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21790\" xsd:anyURI" ]
pg
2024-01-30T15:48:01Z
false
true
2
GO:0141154
141,154
symbiont-mediated suppression of host-directed shutoff of host translation
biological_process
A process in which a symbiont inhibits or disrupts the host shutoff of host translation, a host response that prevents mRNA in the cell to be translated, to prevent the symbiont from expressing its genes. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:20563710", "PMID:21622569" ]
null
[]
[]
[]
[]
[]
[ "GO:0044414" ]
[]
[]
[]
[ "GO:0044414" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26918\" xsd:anyURI" ]
pg
2024-01-31T14:53:32Z
false
true
7
GO:0141155
141,155
symbiont-mediated suppression of host translation elongation
biological_process
A process in which a symbiont inhibits or disrupts the translation elongation of host mRNA into protein, for example by directly inhibiting elongation factors. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:10657208", "PMID:18281405", "PMID:18448518" ]
null
[]
[]
[]
[]
[]
[ "GO:0039656" ]
[]
[]
[]
[ "GO:0039656" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26918\" xsd:anyURI" ]
pg
2024-01-31T15:24:57Z
false
true
2
GO:0141156
141,156
cAMP/PKA signal transduction
biological_process
An intracellular signaling cassette that starts with production of cyclic AMP (cAMP) by adenylate cyclase (either transmembrane or soluble), which activates protein kinase A, and ends with activation of downstream effectors such as the transcription factor CREB that further transmit the signal within the cell.
[ "PMID:23209152" ]
null
[ "cAMP signaling", "cAMP/PKA signaling cassette", "PKA signaling", "protein kinase A signaling" ]
[ "BROAD", "EXACT", "BROAD", "BROAD" ]
[]
[]
[ "Reactome:R-HSA-163358 \"PKA-mediated phosphorylation of key metabolic factors\"" ]
[ "GO:0141124" ]
[]
[]
[]
[ "GO:0141124" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26899\" xsd:anyURI" ]
pg
2024-02-01T08:21:03Z
false
true
4
GO:0141157
141,157
symbiont-mediated suppression of host exocytosis
biological_process
A process in which a symbiont inhibits or disrupts the normal execution of host exocytosis. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:17185412" ]
null
[]
[]
[]
[]
[]
[ "GO:1990215" ]
[]
[]
[]
[ "GO:1990215" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26985\" xsd:anyURI" ]
pg
2024-02-07T15:18:55Z
false
true
4
GO:0141158
141,158
symbiont-mediated suppression of host phagosome maturation
biological_process
A process in which a symbiont inhibits or disrupts the normal maturation of host phagosomes. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:21501366", "PMID:30181274", "PMID:30733336", "PMID:30937925" ]
null
[]
[]
[]
[]
[]
[ "GO:0044068" ]
[]
[]
[]
[ "GO:0044068" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26987\" xsd:anyURI" ]
pg
2024-02-07T16:39:43Z
false
true
1
GO:0141159
141,159
symbiont-mediated suppression of host phagosome acidification
biological_process
A process in which a symbiont inhibits or disrupts the normal acidification of host phagosomes. Mechanisms by which a symbiont prevents host phagosome acidification include the inhibitition of host V-ATPase, the proton pump that acidifies the phagosome, or disruption of the phagosome membrane by pore-forming toxin. The...
[ "PMID:20333253", "PMID:22087003", "PMID:33505976" ]
null
[]
[]
[]
[]
[]
[ "GO:0052031" ]
[]
[]
[]
[ "GO:0052031" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26987\" xsd:anyURI" ]
pg
2024-02-07T16:39:57Z
false
true
2
GO:0141160
141,160
symbiont-mediated disruption of host phagosome
biological_process
The process in which an organism effects a change that impairs the structure or function of host phagosomes.
[ "PMID:15487949", "PMID:21412437", "PMID:30057173" ]
null
[]
[]
[]
[]
[]
[ "GO:0052008" ]
[]
[]
[]
[ "GO:0052008" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26987\" xsd:anyURI" ]
pg
2024-02-07T16:47:35Z
false
true
5
GO:0141161
141,161
regulation of cAMP/PKA signal transduction
biological_process
Any process that modulates the frequency, rate or extent of cAMP/PKA signal transduction.
[ "GOC:curators" ]
null
[ "regulation of cAMP/PKA signaling" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:1902531" ]
[ "regulates GO:0141156" ]
[ "regulates" ]
[ "GO:0141156" ]
[ "GO:0141156", "GO:1902531" ]
[ "GO:0065007", "regulates GO:0141156" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26899\" xsd:anyURI" ]
pg
2024-02-12T12:38:23Z
false
true
4
GO:0141162
141,162
negative regulation of cAMP/PKA signal transduction
biological_process
Any process that stops, prevents or reduces the frequency, rate or extent of cAMP/PKA signal transduction.
[ "PMID:17376027" ]
null
[ "negative regulation of cAMP/PKA signaling" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0141161", "GO:1902532" ]
[ "negatively_regulates GO:0141156" ]
[ "negatively_regulates" ]
[ "GO:0141156" ]
[ "GO:0141156", "GO:0141161", "GO:1902532" ]
[ "GO:0065007", "negatively_regulates GO:0141156" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26899\" xsd:anyURI" ]
pg
2024-02-12T12:50:43Z
false
true
2
GO:0141163
141,163
positive regulation of cAMP/PKA signal transduction
biological_process
Any process that activates or increases the frequency, rate or extent of cAMP/PKA signal transduction.
[ "PMID:21585352" ]
null
[ "positive regulation of cAMP/PKA signaling" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0141161", "GO:1902533" ]
[ "positively_regulates GO:0141156" ]
[ "positively_regulates" ]
[ "GO:0141156" ]
[ "GO:0141156", "GO:0141161", "GO:1902533" ]
[ "GO:0065007", "positively_regulates GO:0141156" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26899\" xsd:anyURI" ]
pg
2024-02-12T12:51:33Z
false
true
8
GO:0141165
141,165
glucosinolate transmembrane transporter activity
molecular_function
Enables the transfer of a glucosinolate across a membrane.
[ "PMID:37076627" ]
null
[]
[]
[]
[]
[]
[ "GO:1901505", "GO:1901682" ]
[]
[]
[]
[ "GO:1901505", "GO:1901682" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27069\" xsd:anyURI" ]
pg
2024-02-16T10:11:52Z
false
true
6
GO:0141167
141,167
chromosomal 5-methylcytosine DNA demethylation, oxidation pathway
biological_process
An epigenetic cytosine DNA demethylation pathway that starts with the enzymatic oxidation of the 5-methylcytosine (5meC) to generate 5-hydroxymethylcytosine (5hmC), which successively converted to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). A DNA glycosylase (e. g. TDG) recognizes the intermediate bases 5fC...
[ "PMID:21862972", "PMID:29875631", "PMID:36478523" ]
Note that this term describes one of the biochemical pathways of chromosomal cytosine demethylation but is agnostic to the effect on gene expression. If the data supports it, consider co-annotating to 'positive regulation of gene expression, epigenetic ; GO:0044029' or a child. A similar pathway may also convert chromo...
[ "epigenetic 5-methylcytosine DNA demethylation, oxidation pathway", "epigenetic DNA demethylation, oxidation pathway" ]
[ "RELATED", "RELATED" ]
[]
[]
[ "Reactome:R-HSA-5221030 \"TET1,2,3 and TDG demethylate DNA\"" ]
[ "GO:0141137", "GO:0141166" ]
[]
[]
[]
[ "GO:0141137", "GO:0141166" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27078\" xsd:anyURI" ]
pg
2024-02-16T13:09:04Z
false
true
6
GO:0141169
141,169
chromosomal 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway
biological_process
An epigenetic cytosine DNA demethylation pathway that involves a DNA glycosylase that directly excises 5-methylcytosine (5-meC) to initiate its replacement with unmethylated cytosine through base excision repair. This pathway is known to occur in plants. In addition to CG sites, plants also methylate cytosines within C...
[ "PMID:21862972", "PMID:31546611", "PMID:36478523" ]
Note that this term describes one of the biochemical pathways of chromosomal cytosine demethylation but is agnostic to the effect on gene expression. If the data supports it, consider co-annotating to 'positive regulation of gene expression, epigenetic ; GO:0044029' or a child.
[ "epigenetic 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway" ]
[ "RELATED" ]
[]
[]
[]
[ "GO:0141166" ]
[]
[]
[]
[ "GO:0141166" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27078\" xsd:anyURI" ]
pg
2024-02-16T14:20:55Z
false
true
9
GO:0141170
141,170
positive regulation of 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway
biological_process
Any process that activates or increases the frequency, rate or extent of positive regulation of 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway.
[ "PMID:36478523" ]
null
[]
[]
[]
[]
[]
[ "GO:0051054" ]
[ "positively_regulates GO:0141169" ]
[ "positively_regulates" ]
[ "GO:0141169" ]
[ "GO:0051054", "GO:0141169" ]
[ "GO:0065007", "positively_regulates GO:0141169" ]
[]
[]
[]
[]
[]
pg
2024-02-16T14:40:06Z
false
true
2
GO:0141171
141,171
symbiont-mediated perturbation of host membrane
biological_process
The process in which a symbiont effects a change that impairs the structure or function of a host membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction.
[ "PMID:14688136", "PMID:17043230", "PMID:28855258" ]
null
[ "symbiont-mediated disruption of host membrane" ]
[ "NARROW" ]
[]
[]
[]
[ "GO:0052008" ]
[]
[]
[]
[ "GO:0052008" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27130\" xsd:anyURI" ]
pg
2024-02-22T16:03:28Z
false
true
9
GO:0141173
141,173
symbiont-mediated suppression of host pro-inflammatory cytokine signaling
biological_process
A process by which a symbiont inhibits or disrupts pro-inflammatory cytokine signaling in the host organism, either by disruption of production, sequesteration, or destruction of at least one component of the signaling pathway. Pro-inflammatory cytokines include: IL-1, IL-12, IL-18, TNF, IFN-gamma, and GM-CSF. The host...
[ "PMID:20008527", "PMID:24508400", "PMID:32117813" ]
null
[ "negative regulation by symbiont of host pro-inflammatory cytokine production", "suppression by symbiont of host pro-inflammatory cytokine production", "suppression by symbiont of host pro-inflammatory cytokine secretion", "symbiont-mediated degradation of host pro-inflammatory cytokine", "symbiont-mediated...
[ "EXACT", "EXACT", "RELATED", "NARROW", "RELATED", "RELATED" ]
[]
[]
[]
[ "GO:0075109" ]
[]
[]
[]
[ "GO:0075109" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27129\" xsd:anyURI" ]
pg
2024-02-22T16:33:40Z
false
true
2
GO:0141174
141,174
symbiont-mediated suppression of host anti-inflammatory cytokine signaling
biological_process
A process by which a symbiont inhibits or disrupts anti-inflammatory cytokine signaling in the host organism, either by disruption of production, sequesteration, or destruction of at least one component of the signaling pathway. Anti-inflammatory cytokines include: interleukin (IL)-1, IL-4, IL-6, IL-10, IL-11, and IL-...
[ "PMID:19168731", "PMID:29720526", "PMID:32754056" ]
null
[ "negative regulation by symbiont of host anti-inflammatory cytokine production", "suppression by symbiont of host anti-inflammatory cytokine production", "suppression by symbiont of host anti-inflammatory cytokine secretion", "symbiont-mediated degradation of host anti-inflammatory cytokine", "symbiont-medi...
[ "EXACT", "EXACT", "RELATED", "NARROW", "RELATED", "RELATED" ]
[]
[]
[]
[ "GO:0075109" ]
[]
[]
[]
[ "GO:0075109" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27129\" xsd:anyURI" ]
pg
2024-02-22T16:35:54Z
false
true
7
GO:0141175
141,175
receptor clustering activity
molecular_function
A protein-protein adaptor that acts as a platform for receptor clustering, often serving to amplify the sensitivity of a signaling response.
[ "PMID:19747931", "PMID:21453460", "PMID:33597156" ]
null
[]
[]
[]
[]
[]
[ "GO:0030674" ]
[]
[]
[]
[ "GO:0030674" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27123\" xsd:anyURI" ]
pg
2024-02-26T11:54:52Z
false
true
9
GO:0141176
141,176
gene silencing by piRNA-directed DNA methylation
biological_process
A small RNA-based gene silencing process in which Piwi-associated RNAs (piRNAs) guide de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription.
[ "PMID:32674113", "PMID:38359823" ]
null
[]
[]
[]
[]
[]
[ "GO:0006346", "GO:0140966" ]
[]
[]
[]
[ "GO:0006346", "GO:0140966" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27238\" xsd:anyURI" ]
pg
2024-03-11T13:47:09Z
false
true
3
GO:0141177
141,177
symbiont-mediated evasion of recognition by host innate immune effector
biological_process
A process by which a symbiont mitigates the effects of recognition by a host innate immune effector. Effectors have a direct activity against a symbiont and include complement, antimicrobial peptides, and bacterial restriction enzymes. The host is defined as the larger of the organisms involved in a symbiotic interacti...
[ "PMID:19208801", "PMID:33330873" ]
null
[ "evasion of symbiont recognition by host innate immune effector" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0141043" ]
[]
[]
[]
[ "GO:0141043" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27250\" xsd:anyURI" ]
pg
2024-03-12T13:23:48Z
false
true
8